Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 6.8875484
2A:A:H41 9.395406
3A:A:N50 5.964149
4A:A:S51 4.0565139
5A:A:K53 5.93254139
6A:A:K203 5.74407
7A:A:F208 5.5625415
8A:A:E209 4.98419
9A:A:F212 8.0925459
10A:A:V214 4.405456
11A:A:F219 6.55857758
12A:A:H220 6.39417
13A:A:M221 4.7925458
14A:A:F222 8.965417
15A:A:Q227 6.66419
16A:A:K233 7.328519
17A:A:W234 6.305619
18A:A:N239 4.9525418
19A:A:F246 4.36409
20A:A:D272 4.5675408
21A:A:F273 5.208336159
22A:A:W277 9.5125156
23A:A:W281 11.02515
24A:A:F290 5.5525499
25A:A:Q294 6.155446
26A:A:L297 3.864548
27A:A:Y311 6.1675406
28A:A:F312 5.786508
29A:A:F315 12.8525406
30A:A:Y318 7.09406
31A:A:P321 4.69545
32A:A:Y339 6.70167643
33A:A:R342 7.44544
34A:A:E344 8.8625405
35A:A:F345 7.51408
36A:A:Y358 6.4025404
37A:A:Y360 10.0725408
38A:A:F363 7.65545
39A:A:T364 7.37499
40A:A:D368 6.636599
41A:A:N371 5.25499
42A:A:R374 10.125494
43A:A:F376 7.255658
44A:A:L393 4.244188
45A:A:L394 4.0254168
46B:B:L4 5.91754194
47B:B:L7 4.9054198
48B:B:I18 3.9875407
49B:B:D27 6.1075408
50B:B:I37 5.88402
51B:B:V40 4.61403
52B:B:H54 10.804589
53B:B:K57 11.586519
54B:B:Y59 11.812518
55B:B:W63 6.521437107
56B:B:L70 5.84105
57B:B:D76 7.314589
58B:B:K78 6.5325488
59B:B:W82 10.702509
60B:B:N88 5.1875407
61B:B:K89 7.49409
62B:B:H91 5.605405
63B:B:W99 9.21619
64B:B:Y111 6.3975404
65B:B:Y124 5.168336216
66B:B:H142 6.67125869
67B:B:Y145 7.38618
68B:B:F151 5.96333609
69B:B:T159 6.155469
70B:B:D163 8.448569
71B:B:W169 9.125668
72B:B:Q176 7.2925464
73B:B:F180 6.612537
74B:B:H183 8.37667639
75B:B:L192 4.2825435
76B:B:F199 5.91639
77B:B:V200 6.53406
78B:B:K209 8.968536
79B:B:L210 6.24405
80B:B:W211 8.59538
81B:B:Q220 7.2575427
82B:B:F222 6.46428
83B:B:H225 9.20714729
84B:B:D228 6519
85B:B:F235 7.69571776
86B:B:P236 6.725477
87B:B:N237 8.075475
88B:B:F241 6.885426
89B:B:D246 5.1275409
90B:B:D247 7.1275429
91B:B:R251 8.395428
92B:B:F253 7.745626
93B:B:D258 8.326527
94B:B:Y264 6.32667675
95B:B:F278 6.725477
96B:B:L285 5.3476
97B:B:Y289 6.398577237
98B:B:D298 7.54209
99B:B:K301 5.09254205
100B:B:H311 8.915259
101B:B:R314 11.19518
102B:B:L318 4.77406
103B:B:W332 11.1933619
104B:B:D333 8.41254259
105B:B:W339 10.2925409
106G:G:L19 2.505409
107G:G:E22 5.435429
108G:G:R27 6.1475428
109G:G:Y40 8.2975476
110G:G:D48 6.253336249
111G:G:V54 4.7554116
112G:G:N59 7.0375409
113G:G:F61 5.13608
114R:R:F141 6.3925406
115R:R:Y145 8.9925407
116R:R:Y149 9.4408
117R:R:L153 2.6475406
118R:R:L156 4.71254278
119R:R:L163 2.645408
120R:R:R173 7.9375409
121R:R:F184 9.038336278
122R:R:M231 4.5375406
123R:R:Y233 5.795409
124R:R:W241 10.8265289
125R:R:E245 7.43409
126R:R:Y248 8.7625408
127R:R:W272 7.31254289
128R:R:P275 4.11333609
129R:R:F278 6.5075405
130R:R:V280 4.345402
131R:R:W282 5.1425299
132R:R:W304 5.01406
133R:R:N318 3.5475409
134R:R:L358 3.708509
135R:R:F383 7.6754265
136R:R:F387 5.064265
137R:R:F391 4.83507
138R:R:C401 3.21409
139R:R:E406 6.0754179
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I93 B:B:V133 10.22767.68NoNo074
2B:B:I93 B:B:P94 35.00093.39NoNo075
3B:B:K78 B:B:P94 35.90546.69YesNo085
4B:B:D76 B:B:K78 40.41486.91YesYes898
5B:B:D76 B:B:H54 46.67035.04YesYes899
6B:B:H54 B:B:S72 24.68511.16YesNo099
7B:B:S72 B:B:W82 25.11876.18NoYes099
8B:B:I338 G:G:F61 14.35883.77NoYes058
9B:B:H54 B:B:I80 24.68513.26YesNo098
10B:B:I80 B:B:W82 25.118714.09NoYes089
11A:A:F219 A:A:H41 26.61179.05YesYes086
12A:A:F212 A:A:F219 29.163312.86YesYes598
13A:A:F212 A:A:M221 29.56623.73YesYes598
14A:A:L45 A:A:M221 30.83268.48NoYes088
15A:A:K53 A:A:L45 31.06094.23YesNo098
16A:A:G47 A:A:K53 24.12425.23NoYes1399
17A:A:G47 A:A:L46 39.76523.42NoNo098
18A:A:F246 A:A:L46 40.04093.65YesNo098
19A:A:D272 A:A:F246 70.38564.78YesYes089
20A:A:D272 A:A:R231 70.928910.72YesNo089
21A:A:R231 A:A:W234 71.32388NoYes099
22A:A:W234 B:B:Y145 54.64985.79YesYes198
23B:B:M101 B:B:Y145 92.75637.18NoYes198
24B:B:M101 B:B:Y59 92.81873.59NoYes198
25B:B:W332 B:B:Y59 10010.61YesYes198
26B:B:S316 B:B:W332 77.00226.18NoYes099
27B:B:C317 B:B:S316 76.6423.44NoNo079
28B:B:C317 B:B:M61 76.28524.86NoNo076
29B:B:L70 B:B:M61 50.52844.24YesNo1056
30B:B:L70 B:B:W82 49.74994.56YesYes059
31B:B:Q75 B:B:W99 14.4196.57NoYes199
32A:A:H41 A:A:I383 25.06876.63YesNo068
33B:B:R314 B:B:W332 87.288323.99YesYes189
34A:A:G47 A:A:S51 15.45363.71NoYes1399
35A:A:L297 A:A:Q294 12.38135.32YesYes486
36A:A:L291 A:A:Q294 12.3315.32NoYes486
37A:A:L289 A:A:L291 21.75235.54NoNo098
38A:A:F246 A:A:L289 33.50923.65YesNo099
39A:A:S51 A:A:V247 21.44634.85YesNo097
40A:A:N292 A:A:V247 20.98574.43NoNo097
41B:B:I93 B:B:Y124 24.05038.46NoYes076
42A:A:Q227 B:B:N119 51.12725.28YesNo099
43A:A:Q227 B:B:Y145 37.417210.15YesYes198
44A:A:F246 A:A:F273 19.25115.36YesYes099
45A:A:F273 A:A:F345 12.57216.43YesYes098
46A:A:F345 A:A:L289 12.70068.53YesNo089
47A:A:F345 A:A:L270 21.96748.53YesNo086
48A:A:E344 A:A:L270 14.89533.98YesNo056
49A:A:D378 A:A:Y360 11.774813.79NoYes078
50A:A:F290 A:A:T364 14.25899.08YesYes999
51A:A:N292 A:A:T364 18.7157.31NoYes099
52A:A:H387 R:R:L252 25.981719.28NoNo088
53R:R:L252 R:R:Y248 27.75095.86NoYes088
54R:R:I176 R:R:Y248 28.96486.04NoYes098
55R:R:E245 R:R:I176 65.11865.47YesNo099
56A:A:Y391 R:R:E245 39.70976.73NoYes049
57A:A:Y391 R:R:R173 41.950513.38NoYes049
58R:R:N174 R:R:R173 80.84456.03NoYes099
59R:R:L163 R:R:N174 81.02214.12YesNo089
60R:R:G164 R:R:L163 96.65921.71NoYes038
61R:R:G164 R:R:G165 97.07152.11NoNo033
62R:R:G165 R:R:L166 97.251.71NoNo037
63R:R:E410 R:R:L166 98.13566.63NoNo087
64R:R:E410 R:R:R413 90.96284.65NoNo087
65B:B:F292 R:R:R413 91.0936.41NoNo047
66B:B:F292 B:B:N313 91.2684.83NoNo047
67B:B:N313 B:B:W332 91.47895.65NoYes079
68R:R:E245 R:R:H177 37.904613.54YesNo099
69R:R:H177 R:R:R173 38.87996.77NoYes099
70R:R:C401 R:R:L163 33.43533.17YesYes098
71R:R:E245 R:R:L358 24.17583.98YesYes099
72B:B:D290 B:B:R314 86.000614.29NoYes068
73B:B:C271 B:B:D290 85.72276.22NoNo056
74B:B:C271 B:B:Y289 77.17774.03NoYes2357
75B:B:W297 B:B:Y289 59.05599.65NoYes087
76B:B:W297 B:B:Y264 62.15349.65NoYes085
77B:B:L252 B:B:Y264 49.28255.86NoYes075
78B:B:L252 B:B:L261 48.84244.15NoNo075
79B:B:L261 G:G:V30 47.07372.98NoNo058
80B:B:A26 G:G:V30 44.39493.39NoNo038
81B:B:A26 B:B:Q259 43.94554.55NoNo036
82B:B:Q259 B:B:R22 43.49524.67NoNo066
83B:B:I18 B:B:R22 15.91676.26YesNo076
84B:B:I18 G:G:L19 12.18242.85YesYes079
85B:B:A11 G:G:L19 10.6191.58NoYes059
86B:B:A11 G:G:V16 10.09611.7NoNo057
87B:B:D258 B:B:R22 27.656111.91YesNo076
88B:B:N340 G:G:F61 12.99043.62NoYes098
89B:B:N340 G:G:N59 10.492210.9NoYes099
90B:B:L286 B:B:V327 10.03644.47NoNo076
91B:B:L286 B:B:V296 16.29664.47NoNo075
92B:B:L284 B:B:V296 17.37314.47NoNo055
93B:B:I43 B:B:L284 16.6595.71NoNo035
94B:B:I43 B:B:V40 15.22836.14NoYes033
95B:B:D298 B:B:V40 13.07588.76YesYes093
96B:B:N295 B:B:Y289 14.771611.63NoYes067
97B:B:N295 B:B:V307 17.74147.39NoNo063
98B:B:G306 B:B:V307 24.60481.84NoNo043
99B:B:L286 B:B:L318 13.24694.15NoYes076
100B:B:L318 B:B:T329 12.86664.42YesNo068
101R:R:E410 R:R:S167 17.80714.31NoNo088
102B:B:D312 R:R:S167 17.35347.36NoNo058
103B:B:D312 B:B:D333 17.04145.32NoYes059
104B:B:D333 B:B:H311 15.32867.56YesYes2599
105B:B:G144 B:B:N119 49.73413.39NoNo089
106B:B:D163 B:B:G144 49.2685.03YesNo098
107B:B:D163 B:B:H142 47.31573.78YesYes699
108B:B:H142 B:B:T159 28.63446.85YesYes699
109B:B:C149 B:B:T159 28.99173.38NoYes089
110B:B:C149 B:B:T102 28.48765.07NoNo088
111B:B:C148 B:B:T102 26.97023.38NoNo068
112B:B:C148 B:B:R150 25.95445.57NoNo066
113B:B:S84 B:B:W63 11.1034.94NoYes057
114B:B:H142 B:B:W169 16.3357.41YesYes698
115B:B:I157 B:B:W169 15.58343.52NoYes078
116B:B:F151 B:B:I157 15.05813.82YesNo097
117B:B:F151 B:B:I123 11.35613.77YesNo096
118B:B:L192 B:B:R150 24.93514.86YesNo056
119B:B:F199 B:B:L192 21.30163.65YesYes395
120B:B:F199 B:B:W211 12.817610.02YesYes398
121B:B:D258 B:B:Q220 11.77996.53YesYes277
122B:B:L210 B:B:Q220 11.74416.65YesYes057
123B:B:D258 B:B:F222 13.76344.78YesYes278
124B:B:A287 B:B:Y289 13.00194NoYes067
125B:B:A287 B:B:V276 12.5793.39NoNo066
126B:B:L285 B:B:V276 11.82524.47YesNo066
127B:B:F278 B:B:L285 24.61377.31YesYes776
128B:B:F235 B:B:F278 16.1089.65YesYes767
129B:B:L285 B:B:Y264 13.99054.69YesYes765
130R:R:C401 R:R:F402 26.422.79YesNo099
131R:R:F402 R:R:V398 25.40423.93NoNo096
132R:R:L394 R:R:V398 24.38492.98NoNo056
133R:R:F391 R:R:L394 23.8742.44YesNo075
134R:R:F387 R:R:F391 11.35617.5YesYes057
135R:R:F391 R:R:S390 10.82393.96YesNo079
136R:R:S390 R:R:Y149 10.29088.9NoYes098
137R:R:I176 R:R:W241 55.6494.7NoYes099
138R:R:W241 R:R:W272 49.235117.81YesYes2899
139R:R:W272 R:R:Y233 47.85436.75YesYes099
140R:R:V279 R:R:Y233 26.7533.79NoYes069
141R:R:L307 R:R:V279 22.8394.47NoNo076
142R:R:L307 R:R:W304 22.36017.97NoYes076
143R:R:P275 R:R:Y233 19.68479.74YesYes099
144R:R:R308 R:R:W304 12.8593NoYes066
145R:R:L358 R:R:N318 11.4472.75YesYes099
146R:R:A274 R:R:P275 16.03971.87NoYes049
147R:R:A274 R:R:F278 14.4514.16NoYes045
148B:B:M61 B:B:W63 25.40598.14NoYes1067
149B:B:S84 G:G:F61 10.67625.28NoYes058
150B:B:I338 B:B:W63 11.46584.7NoYes057
151B:B:G306 B:B:V296 22.19751.84NoNo045
152B:B:H311 B:B:T329 13.02246.85YesNo098
153A:A:Q227 A:A:W234 13.7575.48YesYes199
154A:A:H387 A:A:I383 24.94073.98NoNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:A274 R:R:F278 4.16 0 No Yes 4 5 1 1
R:R:L277 W:W:D11 5.43 0 No No 4 0 1 0
R:R:F278 R:R:P310 14.45 0 Yes No 5 9 1 2
R:R:F278 W:W:M10 4.98 0 Yes No 5 0 1 0
R:R:V285 R:R:W282 3.68 0 No Yes 5 9 2 1
R:R:I306 R:R:W282 8.22 29 No Yes 8 9 1 1
R:R:W282 W:W:F5 8.02 29 Yes No 9 0 1 0
R:R:W282 W:W:M10 4.65 29 Yes No 9 0 1 0
R:R:I306 W:W:F5 6.28 29 No No 8 0 1 0
R:R:F309 W:W:V9 3.93 0 No No 4 0 1 0
R:R:I306 W:W:S6 3.1 29 No No 8 0 1 0
R:R:F309 R:R:P310 2.89 0 No No 4 9 1 2
R:R:L266 W:W:N15 2.75 0 No No 3 0 1 0
R:R:F278 R:R:L277 2.44 0 Yes No 5 4 1 1
R:R:A274 R:R:P275 1.87 0 No Yes 4 9 1 2
R:R:A274 W:W:L13 1.58 0 No No 4 0 1 0
R:R:F263 R:R:L266 1.22 0 No No 5 3 2 1
R:R:W282 W:W:L8 1.14 29 Yes No 9 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
21.43Single8IYXYL-3658IYX-GPR34-YL-365
14.29Single8IZBLysophosphatidylserine (UBL)8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
14.29Single8XBHPubChem 1626566368XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
14.29Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
13.33Single5O9HNDT95137275O9H-C5a1-NDT9513727
13.33Single8K4NPubChem 1687197658K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
12.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
11.76Single8IZ4Lysophosphatidylserine (TJR)8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
11.11Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.11Single8XBIPubChem 1626566368XBI-GPR34-PubChem 162656636
11.11Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
11.11Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
10.71Single8KGGLysophosphatidylserine (WJS)8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
10.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
10.00Single8XBES3E-Lysophosphatidylserine 8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
10.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
10.00Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
9.52Single8SAILysophosphatidylserine (S12)8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
9.52Single8XZFWN5618XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
9.52Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
8.70Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
8.70Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.70Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
8.70Single9KT7MK68929KT7-HCA2-MK6892-Gi1/β1/γ2
8.33Single9NS9PubChem 1186158109NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
8.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
8.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
7.69Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
7.69Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.69Single8J6QPubChem 251012238J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
7.69Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.69Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.14Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
7.14Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
7.14Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
7.14Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
7.14Single8J6PPubChem 251012238J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
7.14Single8JHYPubChem 251012238JHY-HCA2-PubChem 25101223-Gi1/β1/γ2
7.14Single8JIIPubChem 251012238JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
7.14Single9CM3PubChem 1186158109CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.67Single7LJCMevidalen7LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
6.67Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
6.67Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
6.67Single9M8VAF643949M8V-GPR3 ; GPR3-AF64394-chim(NtGi1-Gs)/β1/γ2
6.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
6.25Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
6.25Single7VV6C48/807VV6-MRGPRX2-C48/80
6.25Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
6.25Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9K1DButyric acid9K1D-FFA2-Butyric acid-Gi1/β1/γ2
6.25Single9M8VAF643949M8V-GPR3 ; GPR3-AF64394-chim(NtGi1-Gs)/β1/γ2
5.88Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
5.88Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
5.88Single8XBGS3E-Lysophosphatidylserine 8XBG-GPR34-S3E-Lysophosphatidylserine
5.88Single9IYAONO-97105319IYA-GPR55-ONO-9710531
5.88Single9M8PAF643949M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
5.56Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.56Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
5.56Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.56Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.56Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
5.56Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.56Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56Single8YYXLeukotriene E48YYX-Oxoglutarate-Leukotriene E4-chim(Gi1-CtGq)/β1/γ2
5.56Single8ZMFPubChem 1719206738ZMF-5-HT2C-PubChem 171920673
5.56Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
5.56Single9IYBA1D5Q9IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
5.56Single9M88AF643949M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
5.56Single9M8PAF643949M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
5.56Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
5.56Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
5.26Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
5.26Single7EW4CYM-55417EW4-S1P3-CYM-5541-Gi1/β1/γ2
5.26Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.26Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.26Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
5.26Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
5.26Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
5.26Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
5.26Single9M88AF643949M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
5.26Single9YDVMRS29059YDV-P2Y14-MRS2905-Gi1/β1/γ2
5.26Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
5.26Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
5.26Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
5.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
5.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Single8DWCBAM8-228DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
5.00Single8WRBLysophosphatidylserine (UBL)8WRB-GPR34-Lysophosphatidylserine (UBL)-Gi1/β1/γ2
5.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.00Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
5.00Single9CM3TUG-13759CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single9YDUUDP-Glucose9YDU-P2Y14-UDP-Glucose-Gi1/β1/γ2
5.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.76Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.76Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
4.76Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
4.76Single9J0BUDP-Glucose9J0B-P2Y14-UDP-Glucose-Gi1/β1/γ2
4.76Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
4.76Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
4.55Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.55Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
4.55Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
4.55Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9NS9TUG-13759NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
4.35Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
4.35Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
4.35Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
4.35Single8DWGBAM8-228DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
4.35Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
4.35Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
4.35Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
4.35Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
4.35Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
4.35Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
4.35Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
4.35Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
4.17Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
4.17Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
4.00Single8XZGApelin-138XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
4.00Single9UYIChemerin-99UYI-CML2-Chemerin-9-Arrestin2
3.85Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.85Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
3.85Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
3.85Consensusapelin_onOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.85Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.85Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
3.70Single7XV3Lysophosphatidylserine (WJS)7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
3.70Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.57Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
3.45Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.45Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
3.33Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
2.70Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.70Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2

PDB Summary
PDB 8WG8
Class B1
SubFamily Peptide
Type Glucagon
SubType Glucagon
Species Homo Sapiens
Ligand -
Other Ligand(s) Peptide
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.71
Date 2024-03-06
D.O.I. doi.org/10.1038/s41421-024-00649-0
Net Summary
Imin 3.39
Number of Linked Nodes 861
Number of Links 985
Number of Hubs 139
Number of Links mediated by Hubs 530
Number of Communities 29
Number of Nodes involved in Communities 173
Number of Links involved in Communities 230
Path Summary
Number Of Nodes in MetaPath 155
Number Of Links MetaPath 154
Number of Shortest Paths 689661
Length Of Smallest Path 3
Average Path Length 24.3139
Length of Longest Path 55
Minimum Path Strength 1.385
Average Path Strength 6.43439
Maximum Path Strength 22.355
Minimum Path Correlation 0.7
Average Path Correlation 0.974479
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 53.4166
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.3498
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • system process   • regulation of biological process   • nervous system process   • neuromuscular process   • regulation of system process   • biological regulation   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • serotonin receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • adenylate cyclase-activating dopamine receptor signaling pathway   • G protein-coupled dopamine receptor signaling pathway   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • relaxation of smooth muscle   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cell projection   • sperm principal piece   • cilium   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • plasma membrane bounded cell projection   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • ciliary basal body   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • plasma membrane region   • cell projection membrane   • synapse   • cell junction   • cell body   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • peptide hormone binding   • hormone binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • circulatory system process   • regulation of blood pressure   • blood circulation   • regulation of biosynthetic process   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • response to hormone   • cellular response to hormone stimulus   • carbohydrate metabolic process   • energy derivation by oxidation of organic compounds   • glycogen metabolic process   • primary metabolic process   • regulation of generation of precursor metabolites and energy   • generation of precursor metabolites and energy   • regulation of polysaccharide metabolic process   • regulation of primary metabolic process   • glucan metabolic process   • polysaccharide metabolic process   • energy reserve metabolic process   • regulation of glycogen metabolic process   • regulation of carbohydrate metabolic process   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to nutrient levels   • response to nutrient levels   • response to starvation   • cellular response to starvation   • cell surface receptor signaling pathway   • response to nutrient   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • G-protein beta-subunit binding   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8WG8_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIVKT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVA SSSYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRVF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8WG8_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8WG8_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP47871
Sequence
>8WG8_Chain_R
AKMYSSFQV MYTVGYSLS LGALLLALA ILGGLSKLH CTRNAIHAN 
LFASFVLKA SSVLVIDGL LRTRYAVAG CRVAAVFMQ YGIVANYCW 
LLVEGLYLH NLLGLATLP ERSFFSLYL GIGWGAPML FVVPWAVVK 
CLFENVQCW TSNFWWILR FPVFLAILI NFFIFVRIV QLLVAKLRA 
RQMHHTDYK FRLAKSTLT LIPLLGVHE VVFAFVQGT LRSAKLFFD 
LFLSSFQGL LVAVLYCFL NKEVQSELR RRWHRWRLG KV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-24doi.org/10.1038/nature12393
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-20doi.org/10.1038/nature17414
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-24doi.org/10.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-24doi.org/10.1038/nature22363
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
5YQZB1PeptideGlucagonGlucagonHomo sapiensNNC1702--32018-01-17doi.org/10.1038/nature25153
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-01doi.org/10.1126/science.aaz5346
6LMK (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.72020-04-01doi.org/10.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-01doi.org/10.1126/science.aaz5346
6LML (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.92020-04-01doi.org/10.1126/science.aaz5346
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-27doi.org/10.1074/jbc.RA120.013793
6WHC (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-3.42020-05-27doi.org/10.1074/jbc.RA120.013793
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
6WPWB1PeptideGlucagonGlucagonHomo sapiensZP3780-Gs/β1/γ23.12020-08-12doi.org/10.1126/science.aba3373
6WPW (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensZP3780-3.12020-08-12doi.org/10.1126/science.aba3373
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-12doi.org/10.1038/s41467-020-17791-4
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-18doi.org/10.1038/s41467-020-18945-0
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-16doi.org/10.1038/s41422-020-00442-0
7D68 (No Gprot) B1PeptideGlucagonGLP-2Homo sapiensGLP-2-32020-12-16doi.org/10.1038/s41422-020-00442-0
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-04doi.org/10.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-04doi.org/10.7554/eLife.68719
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7S1MB1PeptideGlucagonGLP-1Homo sapiensExendin-4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensTirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ23.22022-03-02doi.org/10.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide (non-acylated)-3.22022-03-02doi.org/10.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensTirzepatide (non-acylated)-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide (non-acylated)-32022-03-02doi.org/10.1038/s41467-022-28683-0
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-02doi.org/10.1038/s41467-022-28683-0
7V35 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-3.52022-03-02doi.org/10.1038/s41467-022-28683-0
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-13doi.org/10.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-13doi.org/10.1073/pnas.2116506119
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatideLSN3556672chim(NtGi1-Gs)/β1/γ23.082022-04-13doi.org/10.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatideLSN35566723.082022-04-13doi.org/10.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8FU6B1PeptideGlucagonGlucagonHomo sapiensZP3780-Gs/β1/γ22.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8FU6 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensZP3780-2.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-16doi.org/10.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-16doi.org/10.1038/s41586-023-06420-x
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-06doi.org/10.1073/pnas.2303696120
8JIT (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensMEDI0382-2.912023-09-06doi.org/10.1073/pnas.2303696120
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-13doi.org/10.1073/pnas.2303696120
8JIQ (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-15-3.42023-09-13doi.org/10.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-13doi.org/10.1073/pnas.2303696120
8JIU (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensSAR425899-2.762023-09-13doi.org/10.1073/pnas.2303696120
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-18doi.org/10.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-18doi.org/10.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-18doi.org/10.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-18doi.org/10.1073/pnas.2306145120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ23.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-2.842024-09-18doi.org/10.1038/s41421-024-00700-0
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiens-Peptide2.712024-03-06doi.org/10.1038/s41421-024-00649-0
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published
9E2AB1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ23.32025-10-29To be published
9E2A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-3.32025-10-29To be published




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