Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 6.8875484
2A:A:H41 9.395406
3A:A:N50 5.964179
4A:A:S51 4.0565169
5A:A:K53 5.93254169
6A:A:F208 5.5625415
7A:A:E209 4.98419
8A:A:F212 8.0925459
9A:A:V214 4.405456
10A:A:F219 6.55857758
11A:A:H220 6.39417
12A:A:M221 4.7925458
13A:A:F222 8.965417
14A:A:Q227 6.66419
15A:A:K233 7.328519
16A:A:W234 6.305619
17A:A:F246 4.36409
18A:A:D272 4.5675408
19A:A:F273 5.208336189
20A:A:W277 9.5125186
21A:A:W281 11.02515
22A:A:F290 5.55254109
23A:A:Q294 6.155446
24A:A:L297 3.864548
25A:A:Y311 6.1675406
26A:A:F312 6.8725408
27A:A:F315 12.8525406
28A:A:Y318 7.09406
29A:A:P321 4.69545
30A:A:Y339 6.70167643
31A:A:R342 7.44544
32A:A:E344 8.8625405
33A:A:F345 7.51408
34A:A:Y358 6.4025404
35A:A:Y360 10.0725408
36A:A:F363 7.65545
37A:A:T364 7.374109
38A:A:D368 6.6365109
39A:A:N371 5.254109
40A:A:R374 10.1254104
41A:A:F376 7.255658
42A:A:L393 4.244218
43A:A:L394 4.0254198
44B:B:I18 3.9875407
45B:B:D27 6.1075408
46B:B:I37 5.88402
47B:B:V40 4.61403
48B:B:H54 10.804589
49B:B:K57 12.416519
50B:B:Y59 11.812518
51B:B:W63 6.521437117
52B:B:L70 5.84115
53B:B:D76 7.314589
54B:B:K78 6.5325488
55B:B:W82 10.702509
56B:B:N88 5.1875407
57B:B:K89 7.49409
58B:B:H91 5.605405
59B:B:W99 9.21619
60B:B:Y111 6.3975404
61B:B:Y124 5.16833696
62B:B:E138 6.9375496
63B:B:H142 6.67125869
64B:B:Y145 7.38618
65B:B:F151 5.96333609
66B:B:T159 6.155469
67B:B:D163 8.448569
68B:B:W169 9.125668
69B:B:Q176 7.2925464
70B:B:F180 6.612537
71B:B:H183 8.37667639
72B:B:L192 4.2825435
73B:B:F199 5.91639
74B:B:V200 6.53406
75B:B:K209 8.968536
76B:B:L210 5.478505
77B:B:W211 8.59538
78B:B:R219 6.594135
79B:B:Q220 7.2575427
80B:B:F222 6.46428
81B:B:H225 8.81571729
82B:B:D228 6519
83B:B:I232 5.11408
84B:B:F235 7.69571776
85B:B:P236 6.725477
86B:B:N237 8.075475
87B:B:F241 6.885426
88B:B:D246 5.1275409
89B:B:D247 7.1275429
90B:B:R251 8.395428
91B:B:F253 7.96167626
92B:B:D258 8.326527
93B:B:Y264 6.32667675
94B:B:F278 6.725477
95B:B:L285 5.3476
96B:B:Y289 6.398577237
97B:B:D298 7.54229
98B:B:K301 5.09254225
99B:B:H311 8.915259
100B:B:R314 11.19518
101B:B:L318 4.77406
102B:B:W332 11.1933619
103B:B:D333 8.41254259
104B:B:W339 10.2925409
105G:G:L19 2.505409
106G:G:E22 5.435429
107G:G:R27 6.1475428
108G:G:Y40 8.2975476
109G:G:D48 6.253336249
110G:G:V54 4.7554146
111G:G:N59 6.7375409
112G:G:F61 5.13608
113R:R:F141 6.3925406
114R:R:Y145 8.9925407
115R:R:Y149 9.4408
116R:R:L153 2.6475406
117R:R:L156 4.71254278
118R:R:L163 2.645408
119R:R:R173 7.9375409
120R:R:F184 9.038336278
121R:R:M231 4.5375406
122R:R:Y233 7.275129
123R:R:W241 10.8265129
124R:R:E245 7.43409
125R:R:Y248 8.7625408
126R:R:W272 7.31254129
127R:R:P275 4.613336129
128R:R:F278 6.5075405
129R:R:W282 5.1425289
130R:R:W304 4.76406
131R:R:R308 5.435406
132R:R:N318 3.5475409
133R:R:L358 3.708509
134R:R:F365 6.164297
135R:R:F383 7.6754265
136R:R:F387 5.064265
137R:R:F391 4.83507
138R:R:C401 3.21409
139R:R:E406 7.76254209
140R:R:E410 5.9225408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I93 B:B:V133 10.17047.68NoNo074
2B:B:I93 B:B:P94 33.00253.39NoNo075
3B:B:K78 B:B:P94 33.90376.69YesNo085
4B:B:D76 B:B:K78 38.39666.91YesYes898
5B:B:D76 B:B:H54 44.63055.04YesYes899
6B:B:H54 B:B:S72 23.659711.16YesNo099
7B:B:S72 B:B:W82 24.09236.18NoYes099
8B:B:I338 G:G:F61 14.1263.77NoYes058
9B:B:H54 B:B:I80 23.659713.26YesNo098
10B:B:I80 B:B:W82 24.092314.09NoYes089
11A:A:F219 A:A:H41 26.36319.05YesYes086
12A:A:F212 A:A:F219 28.817612.86YesYes598
13A:A:F212 A:A:M221 29.19493.73YesYes598
14A:A:L45 A:A:M221 30.47328.48NoYes088
15A:A:K53 A:A:L45 30.70434.23YesNo098
16A:A:G47 A:A:K53 23.29895.23NoYes1699
17A:A:G47 A:A:L46 40.23643.42NoNo098
18A:A:F246 A:A:L46 40.50513.65YesNo098
19A:A:D272 A:A:F246 69.36074.78YesYes089
20A:A:D272 A:A:R231 69.921310.72YesNo089
21A:A:R231 A:A:W234 70.33418NoYes099
22A:A:W234 B:B:Y145 54.00335.79YesYes198
23B:B:M101 B:B:Y145 92.82277.18NoYes198
24B:B:M101 B:B:Y59 92.88313.59NoYes198
25B:B:W332 B:B:Y59 10010.61YesYes198
26B:B:S316 B:B:W332 74.96776.18NoYes099
27B:B:C317 B:B:S316 74.60693.44NoNo079
28B:B:C317 B:B:M61 74.24954.86NoNo076
29B:B:L70 B:B:M61 48.6574.24YesNo1156
30B:B:L70 B:B:W82 47.86024.56YesYes059
31B:B:Q75 B:B:W99 14.30346.57NoYes199
32A:A:H41 A:A:I383 24.89166.63YesNo068
33B:B:R314 B:B:W332 87.71323.99YesYes189
34A:A:G47 A:A:S51 16.75033.71NoYes1699
35A:A:L297 A:A:Q294 12.43235.32YesYes486
36A:A:L291 A:A:Q294 12.20755.32NoYes486
37A:A:L289 A:A:L291 21.14735.54NoNo098
38A:A:F246 A:A:L289 32.09263.65YesNo099
39A:A:S51 A:A:V247 23.22884.85YesNo097
40A:A:N292 A:A:V247 22.77214.43NoNo097
41B:B:I93 B:B:Y124 22.09378.46NoYes076
42A:A:Q227 B:B:N119 51.66875.28YesNo099
43A:A:Q227 B:B:Y145 38.165510.15YesYes198
44A:A:F246 A:A:F273 18.34475.36YesYes099
45A:A:F273 A:A:F345 11.65296.43YesYes098
46A:A:F345 A:A:L289 11.73828.53YesNo089
47A:A:F345 A:A:L270 20.10768.53YesNo086
48A:A:E344 A:A:L270 13.92823.98YesNo056
49A:A:D378 A:A:Y360 13.721213.79NoYes078
50A:A:F290 A:A:T364 16.08499.08YesYes1099
51A:A:N292 A:A:T364 20.52047.31NoYes099
52A:A:H387 R:R:L252 25.81619.28NoNo088
53R:R:L252 R:R:Y248 27.59035.86NoYes088
54R:R:I176 R:R:Y248 28.8136.04NoYes098
55R:R:E245 R:R:I176 60.42475.47YesNo099
56A:A:Y391 R:R:E245 36.80686.73NoYes049
57A:A:Y391 R:R:R173 39.018913.38NoYes049
58R:R:N174 R:R:R173 74.99136.03NoYes099
59R:R:L163 R:R:N174 75.17094.12YesNo089
60R:R:G164 R:R:L163 94.48431.71NoYes038
61R:R:G164 R:R:G165 94.90382.11NoNo033
62R:R:G165 R:R:L166 95.08761.71NoNo037
63R:R:E410 R:R:L166 96.00016.63YesNo087
64R:R:E410 R:R:R413 90.20774.65YesNo087
65B:B:F292 R:R:R413 90.3376.41NoNo047
66B:B:F292 B:B:N313 90.5114.83NoNo047
67B:B:N313 B:B:W332 90.72065.65NoYes079
68R:R:E245 R:R:H177 35.000413.54YesNo099
69R:R:H177 R:R:R173 35.95186.77NoYes099
70R:R:E245 R:R:L358 27.80833.98YesYes099
71B:B:D290 B:B:R314 86.411414.29NoYes068
72B:B:C271 B:B:D290 86.14026.22NoNo056
73B:B:C271 B:B:Y289 77.47634.03NoYes2357
74B:B:W297 B:B:Y289 59.55669.65NoYes087
75B:B:W297 B:B:Y264 62.79149.65NoYes085
76B:B:L252 B:B:Y264 50.1255.86NoYes075
77B:B:L252 B:B:L261 49.69164.15NoNo075
78B:B:L261 G:G:V30 47.94942.98NoNo058
79B:B:A26 G:G:V30 45.31063.39NoNo038
80B:B:A26 B:B:Q259 44.86794.55NoNo036
81B:B:Q259 B:B:R22 44.42434.67NoNo066
82B:B:I18 B:B:R22 15.7146.26YesNo076
83B:B:I18 G:G:L19 12.00942.85YesYes079
84B:B:A11 G:G:L19 10.46831.58NoYes059
85B:B:D258 B:B:R22 28.763111.91YesNo076
86B:B:N340 G:G:F61 12.78633.62NoYes098
87B:B:N340 G:G:N59 10.309810.9NoYes099
88B:B:L286 B:B:V296 16.38154.47NoNo075
89B:B:L284 B:B:V296 17.2264.47NoNo055
90B:B:I43 B:B:L284 16.5185.71NoNo035
91B:B:I43 B:B:V40 15.09936.14NoYes033
92B:B:D298 B:B:V40 12.9658.76YesYes093
93B:B:N295 B:B:Y289 1511.63NoYes067
94B:B:N295 B:B:V307 18.10357.39NoNo063
95B:B:G306 B:B:V307 25.11221.84NoNo043
96B:B:L286 B:B:L318 13.3144.15NoYes076
97B:B:L318 B:B:T329 12.93334.42YesNo068
98R:R:E410 R:R:S167 17.76594.31YesNo088
99B:B:D312 R:R:S167 17.31737.36NoNo058
100B:B:D312 B:B:D333 17.01145.32NoYes059
101B:B:D333 B:B:H311 15.33557.56YesYes2599
102B:B:G144 B:B:N119 49.39383.39NoNo089
103B:B:D163 B:B:G144 48.93625.03YesNo098
104B:B:D163 B:B:H142 47.01823.78YesYes699
105B:B:H142 B:B:T159 28.15266.85YesYes699
106B:B:C149 B:B:T159 28.53293.38NoYes089
107B:B:C149 B:B:T102 28.03695.07NoNo088
108B:B:C148 B:B:T102 26.54393.38NoNo068
109B:B:C148 B:B:R150 25.54435.57NoNo066
110B:B:S84 B:B:W63 11.02594.94NoYes057
111B:B:H142 B:B:W169 16.56197.41YesYes698
112B:B:I157 B:B:W169 12.74453.52NoYes078
113B:B:F151 B:B:I157 12.223213.82YesNo097
114B:B:L192 B:B:R150 24.54144.86YesNo056
115B:B:F199 B:B:L192 20.96573.65YesYes395
116B:B:F199 B:B:W211 12.615610.02YesYes398
117B:B:D258 B:B:Q220 11.63936.53YesYes277
118B:B:L210 B:B:Q220 11.59296.65YesYes057
119B:B:D258 B:B:F222 15.02834.78YesYes278
120B:B:A287 B:B:Y289 12.83244NoYes067
121B:B:A287 B:B:V276 12.4153.39NoNo066
122B:B:L285 B:B:V276 11.6744.47YesNo066
123B:B:F278 B:B:L285 24.34037.31YesYes776
124B:B:F235 B:B:F278 15.9299.65YesYes767
125B:B:L285 B:B:Y264 13.86284.69YesYes765
126R:R:C401 R:R:L163 29.47753.17YesYes098
127R:R:C401 R:R:F402 26.52452.79YesNo099
128R:R:F402 R:R:V398 25.53513.93NoNo096
129R:R:L394 R:R:V398 24.54392.98NoNo056
130R:R:F391 R:R:L394 24.0482.44YesNo075
131R:R:F387 R:R:F391 12.03317.5YesYes057
132R:R:F383 R:R:F387 10.5545.36YesYes2655
133R:R:F391 R:R:S390 10.70483.96YesNo079
134R:R:S390 R:R:Y149 10.17768.9NoYes098
135R:R:I176 R:R:W241 48.17164.7NoYes099
136R:R:W241 R:R:W272 41.69117.81YesYes1299
137R:R:W272 R:R:Y233 40.26856.75YesYes1299
138R:R:V279 R:R:Y233 18.23783.79NoYes069
139R:R:L307 R:R:V279 15.06764.47NoNo076
140R:R:L307 R:R:W304 14.47837.97NoYes076
141R:R:P275 R:R:Y233 19.00889.74YesYes1299
142R:R:L358 R:R:N318 13.47452.75YesYes099
143R:R:A274 R:R:P275 16.05321.87NoYes049
144R:R:A274 R:R:F278 14.46314.16NoYes045
145B:B:M61 B:B:W63 25.2418.14NoYes1167
146B:B:S84 G:G:F61 10.60395.28NoYes058
147B:B:I338 B:B:W63 11.38844.7NoYes057
148B:B:G306 B:B:V296 22.33831.84NoNo045
149B:B:H311 B:B:T329 13.07366.85YesNo098
150A:A:Q227 A:A:W234 13.5295.48YesYes199
151A:A:H387 A:A:I383 24.77173.98NoNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:A274 R:R:F278 4.16 0 No Yes 4 5 1 1
R:R:L277 W:W:D11 5.43 0 No No 4 0 1 0
R:R:F278 R:R:P310 14.45 0 Yes No 5 9 1 2
R:R:F278 W:W:M10 4.98 0 Yes No 5 0 1 0
R:R:V285 R:R:W282 3.68 0 No Yes 5 9 2 1
R:R:I306 R:R:W282 8.22 28 No Yes 8 9 1 1
R:R:W282 W:W:F5 8.02 28 Yes No 9 0 1 0
R:R:W282 W:W:M10 4.65 28 Yes No 9 0 1 0
R:R:I306 W:W:F5 6.28 28 No No 8 0 1 0
R:R:F309 W:W:V9 3.93 0 No No 4 0 1 0
R:R:I306 W:W:S6 3.1 28 No No 8 0 1 0
R:R:F309 R:R:P310 2.89 0 No No 4 9 1 2
R:R:L266 W:W:N15 2.75 0 No No 3 0 1 0
R:R:F278 R:R:L277 2.44 0 Yes No 5 4 1 1
R:R:A274 R:R:P275 1.87 0 No Yes 4 9 1 2
R:R:A274 W:W:L13 1.58 0 No No 4 0 1 0
R:R:F263 R:R:L266 1.22 0 No No 5 3 2 1
R:R:W282 W:W:L8 1.14 28 Yes No 9 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
23.53Single7SHEPI; PE7SHE-GPR158-PI; PE
22.22Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
21.43Single8IYXYL-3658IYX-GPR34-YL-365
19.05Single7SHEPI; PE7SHE-GPR158-PI; PE
19.05Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
14.29Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.33Single5O9HNDT95137275O9H-C5a1-NDT9513727
13.33Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.76Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.76Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
11.11Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
10.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
9.52Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
9.52Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
9.52Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
9.09Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
8.70Single5KW2PubChem 1330539535KW2-FFA1 (GPR40)-PubChem 133053953
8.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
8.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
7.69Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
7.69Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.69Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.69Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
7.69Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
7.69Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.14Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.14Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
7.14Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.14Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.14Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.14Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.67Single7LJCMevidalen7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
6.67Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
6.67Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.67Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.67Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
6.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Consensusd1_on_alloOther Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.67Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.25Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
6.25Single7VV6C48/807VV6-MRGPRX2-C48/80
6.25Single7WU3K6G7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
6.25Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.88Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.88Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusadgrf1_on_alloOther Ligand7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
5.88Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
5.88Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
5.88Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
5.56Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.56Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
5.56Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.56Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.56Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
5.26Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
5.26Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.26Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
5.26Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
5.26Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
5.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
5.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
5.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
5.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
5.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.76Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.76Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.76Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
4.76Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
4.76Consensuscyslt_offOrthosteric Ligandcyslt2_off
4.55Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.55Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Consensusclass-d_offOrthosteric Ligandste2_off
4.35Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
4.35Single7QA8Peptide7QA8-STE2-Peptide
4.35Single7QA8Peptide7QA8-STE2-Peptide
4.35Consensusclass-d_offOrthosteric Ligandste2_off
4.17Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
3.85Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.85Consensusclass-d_onOrthosteric Ligandste2_on
3.85Consensusgi_class-dOrthosteric Ligandgi_ste
3.85Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.57Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
3.57Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Consensusclass-d_onOrthosteric Ligandste2_on
3.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.45Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
3.45Consensusgi_class-dOrthosteric Ligandgi_ste
3.45Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
3.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.33Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
3.23Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.23Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.23Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.23Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.23Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.12Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.03Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.03Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.94Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.78Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.63Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.56Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.56Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
2.56Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8WG8
Class B1
SubFamily Peptide
Type Glucagon
SubType Glucagon
Species Homo sapiens
Ligand -
Other Ligand(s) Peptide
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.71
Date 2024-03-06
D.O.I. 10.1038/s41421-024-00649-0
Net Summary
Imin 3.39
Number of Linked Nodes 863
Number of Links 990
Number of Hubs 140
Number of Links mediated by Hubs 536
Number of Communities 29
Number of Nodes involved in Communities 178
Number of Links involved in Communities 236
Path Summary
Number Of Nodes in MetaPath 152
Number Of Links MetaPath 151
Number of Shortest Paths 693222
Length Of Smallest Path 3
Average Path Length 24.0908
Length of Longest Path 53
Minimum Path Strength 1.165
Average Path Strength 6.43642
Maximum Path Strength 19.535
Minimum Path Correlation 0.7
Average Path Correlation 0.974342
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 53.4531
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.5955
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8WG8_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIVKT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVA SSSYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRVF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8WG8_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8WG8_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP47871
Sequence
>8WG8_Chain_R
AKMYSSFQV MYTVGYSLS LGALLLALA ILGGLSKLH CTRNAIHAN 
LFASFVLKA SSVLVIDGL LRTRYAVAG CRVAAVFMQ YGIVANYCW 
LLVEGLYLH NLLGLATLP ERSFFSLYL GIGWGAPML FVVPWAVVK 
CLFENVQCW TSNFWWILR FPVFLAILI NFFIFVRIV QLLVAKLRA 
RQMHHTDYK FRLAKSTLT LIPLLGVHE VVFAFVQGT LRSAKLFFD 
LFLSSFQGL LVAVLYCFL NKEVQSELR RRWHRWRLG KV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/&β;1/&γ;22.62020-11-1810.1038/s41467-020-18945-0
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.62022-04-0610.1073/pnas.2106606118
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/&β;1/&γ;23.292021-10-2010.1073/pnas.2106606118
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/&β;1/&γ;22.982021-08-0410.7554/eLife.68719
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/&β;1/&γ;23.12022-02-2310.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/&β;1/&γ;23.242022-04-1310.1073/pnas.2116506119
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/&β;1/&γ;23.082022-04-1310.1073/pnas.2116506119
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;23.22022-03-0210.1038/s41467-022-28683-0
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.232023-10-1810.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.132023-10-1810.1073/pnas.2306145120
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;22.862024-03-0610.1038/s41421-024-00649-0
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/&β;1/&γ;24.12017-05-2410.1038/nature22394
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/&β;1/&γ;23.32018-02-2110.1038/nature25773
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/&β;1/&γ;232020-01-0810.1038/s41586-019-1902-z
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/&β;1/&γ;23.32020-07-2210.1038/s41589-020-0589-7
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/&β;1/&γ;22.12020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/&β;1/&γ;22.12020-09-0910.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/&β;1/&γ;22.52020-09-0910.1016/j.molcel.2020.09.020
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/&β;1/&γ;23.12020-11-1810.1073/pnas.2014879117
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/&β;1/&γ;24.22020-08-2610.1038/s41422-020-0384-8
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/&β;1/&γ;22.52021-07-1410.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/&β;1/&γ;23.32021-08-1110.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/&β;1/&γ;22.92021-07-0710.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/&β;1/&γ;22.52021-08-1110.1038/s41467-021-24058-z
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/&β;1/&γ;22.52021-08-0410.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/&β;1/&γ;22.52021-08-0410.1016/j.celrep.2021.109374
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/&β;1/&γ;22.92021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/&β;1/&γ;23.72022-01-1210.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/&β;1/&γ;23.32022-01-1210.1038/s41467-021-27760-0
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.22022-04-1310.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/&β;1/&γ;22.92022-04-1310.1073/pnas.2116506119
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/&β;1/&γ;22.142021-10-0610.1016/j.bbrc.2021.09.016
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/&β;1/&γ;22.412022-01-0510.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/&β;1/&γ;22.512022-01-0510.1038/s41589-021-00945-w
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/&β;1/&γ;232022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/&β;1/&γ;232022-03-0210.1038/s41467-022-28683-0
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/&β;1/&γ;22.612022-06-2910.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/&β;1/&γ;23.092022-06-2910.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/&β;1/&γ;22.852023-09-0610.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/&β;1/&γ;22.572023-09-0610.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/&β;1/&γ;22.462023-11-0810.1073/pnas.2303696120
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/&β;1/&γ;22.542024-03-0610.1038/s41421-024-00649-0
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/&β;1/&γ;232020-12-1610.1038/s41422-020-00442-0
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-2410.1038/nature12393
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-2010.1038/nature17414
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-2410.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-2410.1038/nature22363
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-1710.1038/nature25153
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/&β;1/&γ;23.72020-04-0110.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon--3.92020-04-0110.1126/science.aaz5346
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/&β;1/&γ;23.42020-05-2710.1074/jbc.RA120.013793
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/&β;1/&γ;23.12020-08-1210.1126/science.aba3373
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/&β;1/&γ;23.52022-03-0210.1038/s41467-022-28683-0
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/&β;1/&γ;22.92023-04-1210.1016/j.cell.2023.02.028
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/&β;1/&γ;23.42023-09-1310.1073/pnas.2303696120
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/&β;1/&γ;22.912023-09-0610.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/&β;1/&γ;22.762023-09-1310.1073/pnas.2303696120
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-1610.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-1610.1038/s41586-023-06420-x
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/&β;1/&γ;22.712024-03-0610.1038/s41421-024-00649-0
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/&β;1/&γ;24.32020-08-1210.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/&β;1/&γ;22.32020-08-1210.1038/s41467-020-17791-4
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/&β;1/&γ;22.92020-11-0410.1016/j.bbrc.2020.08.042




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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