Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:S51 4.1175409
2A:A:T55 3.2075409
3A:A:F219 6.28714728
4A:A:F222 6.415417
5A:A:Q227 4.974519
6A:A:K233 5.354519
7A:A:W234 5.935619
8A:A:F238 10.0825409
9A:A:Y253 8.4185208
10A:A:F273 5.294159
11A:A:W277 11.88676156
12A:A:W281 9.79515
13A:A:V287 3.70754156
14A:A:I288 6.7425449
15A:A:F290 5.09667649
16A:A:L291 4.266568
17A:A:N292 4.956549
18A:A:Q294 5.505466
19A:A:F312 4.6725148
20A:A:F315 12.535406
21A:A:Y318 8.13406
22A:A:V334 3.49254214
23A:A:K338 7.89465
24A:A:Y339 6.868563
25A:A:F340 13.55754147
26A:A:R342 5.8664
27A:A:E344 6.4545145
28A:A:F345 5.718568
29A:A:Y360 9.386128
30A:A:F363 7.074565
31A:A:T364 6.77549
32A:A:D368 5.738549
33A:A:N371 7.6875449
34A:A:R373 4.505425
35A:A:R374 7.302544
36A:A:F376 5.20857728
37A:A:I383 4.305428
38A:A:R385 6.6256135
39A:A:H387 5.022528
40A:A:L388 4.31408
41A:A:R389 5.474134
42A:A:Y391 8.17714724
43A:A:L394 7.254138
44B:B:L7 3.905408
45B:B:R22 6.5825406
46B:B:I37 4.15402
47B:B:V40 5.384223
48B:B:H54 8.50857779
49B:B:K57 9.27519
50B:B:Y59 5.698518
51B:B:W63 6.59507
52B:B:V71 5.085498
53B:B:S72 6.755479
54B:B:Q75 9.27419
55B:B:I81 5.03497
56B:B:W82 11.7243779
57B:B:Y85 11.86754104
58B:B:N88 5.5475407
59B:B:K89 6.255679
60B:B:H91 6.5525495
61B:B:L95 5.5554258
62B:B:W99 8.31429719
63B:B:M101 4.828519
64B:B:Y105 4.72429796
65B:B:Y111 6.564504
66B:B:I123 4.74416
67B:B:Y124 6.7325406
68B:B:H142 8.13519
69B:B:Y145 8.25833618
70B:B:L146 4.376517
71B:B:C149 4.096518
72B:B:F151 5.8475419
73B:B:I157 5.43517
74B:B:S161 8.465419
75B:B:D163 9.012519
76B:B:W169 7.84833618
77B:B:I171 4.905416
78B:B:F180 7.446587
79B:B:H183 8.328589
80B:B:D186 7.4025419
81B:B:V187 4.3375489
82B:B:M188 4.32418
83B:B:F199 6.9075489
84B:B:V200 7.8425436
85B:B:S201 4.675489
86B:B:C204 5.54417
87B:B:K209 11.6225486
88B:B:L210 5.976535
89B:B:W211 8.15286788
90B:B:Q220 5.4575437
91B:B:F222 7.215438
92B:B:H225 8.85571739
93B:B:D228 8.86419
94B:B:I232 4.395438
95B:B:F234 6.7825405
96B:B:F235 10.622556
97B:B:N237 9.6225455
98B:B:F241 8.256536
99B:B:D247 5.592539
100B:B:R251 8.33167638
101B:B:F253 5.894536
102B:B:D254 3.98659
103B:B:D258 6.436537
104B:B:L261 3.9275455
105B:B:Y264 5.366505
106B:B:F278 6.22667657
107B:B:R283 8.095229
108B:B:Y289 5.36717
109B:B:D290 5.97516
110B:B:N295 5.04516
111B:B:V296 4.9525405
112B:B:K301 4.7825405
113B:B:H311 8.82254169
114B:B:R314 11.266518
115B:B:W332 9.62429719
116B:B:D333 9.37754169
117B:B:L336 4.95477
118B:B:W339 8.5485239
119B:B:N340 3.99254109
120G:G:V16 5.2407
121G:G:K20 5.625406
122G:G:L37 6.0075457
123G:G:P60 6.27254109
124G:G:F61 5.47758108
125R:R:D16 7.225115
126R:R:F19 2.73405
127R:R:P20 5.59754115
128R:R:Y24 6.02609
129R:R:N50 6.8525427
130R:R:L52 4.31428
131R:R:V54 3.268507
132R:R:Y55 7.485627
133R:R:D63 5.9575409
134R:R:Y66 6.36667607
135R:R:I67 3.7175406
136R:R:W73 7.338507
137R:R:F77 6.792867115
138R:R:W83 7.401676289
139R:R:H85 4.98254287
140R:R:F97 9.098507
141R:R:F107 8.59254178
142R:R:R115 8.3525429
143R:R:Y116 10.48408
144R:R:P122 5.415427
145R:R:L123 4.82526
146R:R:W142 6.2625179
147R:R:F169 12.6325404
148R:R:K171 9.64273
149R:R:N182 7.7675405
150R:R:Y201 5.67508
151R:R:T214 6.32254133
152R:R:E218 5.134135
153R:R:L229 5.645408
154R:R:F237 6.27571728
155R:R:Y240 6.72333606
156R:R:H241 9.386528
157R:R:Y251 6.694503
158R:R:F265 14.935404
159R:R:Y268 9.7254115
160R:R:H269 8.025115
161R:R:D282 7.7575429
162R:R:Y286 5.724529
163R:R:N290 7.045408
164W:W:?1 7.07778920
165W:W:?2 10.972500
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C148 B:B:T102 11.45753.38NoNo068
2B:B:C149 B:B:T102 11.54333.38YesNo088
3B:B:C149 B:B:L146 13.66263.17YesYes187
4B:B:L146 B:B:S161 13.8554.5YesYes179
5B:B:G162 B:B:S161 17.66293.71NoYes199
6B:B:G162 B:B:Y145 17.37657.24NoYes198
7A:A:W234 B:B:Y145 43.40998.68YesYes198
8A:A:F238 A:A:W234 43.93734.01YesYes099
9A:A:F238 B:B:W99 52.279214.03YesYes099
10A:A:H387 A:A:Y391 11.48556.53YesYes284
11A:A:Y391 R:R:L52 23.54684.69YesYes248
12R:R:I111 R:R:L52 27.24124.28NoYes298
13R:R:I111 R:R:R115 26.70267.52NoYes299
14A:A:L393 R:R:R115 96.732714.58NoYes089
15A:A:L388 A:A:L393 96.87264.15YesNo088
16A:A:L388 A:A:L394 97.89064.15YesYes088
17A:A:L394 A:A:R385 97.76988.5YesYes1385
18A:A:R385 R:R:S213 99.68519.22YesNo053
19A:A:Y358 R:R:S213 49.91125.09NoNo043
20A:A:Y358 A:A:Y360 49.92998.94NoYes1248
21A:A:D378 A:A:Y360 10022.99NoYes078
22A:A:D378 A:A:H362 96.615810.08NoNo079
23A:A:H362 A:A:R374 93.961212.41NoYes094
24A:A:D368 A:A:R374 91.83394.76YesYes494
25A:A:C365 A:A:D368 96.19616.22NoYes089
26A:A:C365 A:A:Q294 96.21123.05NoYes086
27A:A:L291 A:A:Q294 94.30843.99YesYes686
28A:A:L289 A:A:L291 93.08535.54NoYes698
29A:A:C359 A:A:L289 95.76974.76NoNo059
30A:A:C359 A:A:F273 95.31934.19NoYes059
31A:A:F273 A:A:V287 94.92933.93YesYes1596
32A:A:I244 A:A:V287 95.27963.07NoYes086
33A:A:I244 A:A:L44 95.19118.56NoNo089
34A:A:F238 A:A:L44 94.961417.05YesNo099
35A:A:D381 R:R:S213 49.91124.42NoNo083
36A:A:D381 A:A:Y360 49.92995.75NoYes1288
37B:B:M188 B:B:Y145 26.4033.59YesYes188
38A:A:K233 B:B:M188 17.52755.76YesYes198
39B:B:C204 B:B:D228 17.4729.34YesYes179
40A:A:W281 B:B:W332 15.81565.62YesYes159
41B:B:S316 B:B:W332 13.09044.94NoYes099
42B:B:C317 B:B:S316 12.89723.44NoNo079
43B:B:C317 B:B:M61 12.51084.86NoNo076
44B:B:A328 B:B:M61 12.32483.22NoNo056
45B:B:A328 B:B:W63 12.13973.89NoYes057
46B:B:R314 B:B:W332 32.393619.99YesYes189
47B:B:Q75 B:B:Y59 25.207711.27YesYes198
48B:B:K57 B:B:W332 25.140913.92YesYes199
49A:A:W281 B:B:D290 15.08645.58YesYes156
50B:B:D290 B:B:R314 15.062411.91YesYes168
51A:A:Y391 R:R:D114 12.49848.05YesNo248
52B:B:C271 B:B:D290 29.76754.67NoYes156
53B:B:C271 B:B:Y289 27.83864.03NoYes157
54B:B:I273 B:B:Y289 21.71249.67NoYes067
55B:B:C250 B:B:I273 20.94316.55NoNo086
56B:B:C250 B:B:Y264 20.55834.03NoYes085
57B:B:M262 B:B:Y264 10.09669.58NoYes045
58B:B:R314 B:B:T274 16.98417.76YesNo188
59B:B:S275 B:B:T274 17.20674.8NoNo088
60B:B:L318 B:B:S275 16.82533NoNo068
61B:B:C294 B:B:L318 16.44363.17NoNo056
62B:B:L198 B:B:L210 11.09675.54NoYes335
63B:B:D228 B:B:S227 25.80615.89YesNo096
64B:B:D247 B:B:S227 33.93124.42YesNo096
65B:B:D247 B:B:H225 29.51583.78YesYes399
66B:B:F253 B:B:H225 19.65393.39YesYes369
67R:R:R115 R:R:Y286 61.54246.17YesYes299
68R:R:L108 R:R:Y286 61.83417.03NoYes289
69R:R:D282 R:R:L108 61.4779.5YesNo298
70R:R:D282 R:R:N278 29.62949.42YesNo299
71R:R:F237 R:R:N278 28.930414.5YesNo289
72R:R:F237 R:R:H241 17.22563.39YesYes288
73R:R:H241 R:R:Y240 11.78993.27YesYes086
74R:R:Y240 R:R:Y268 10.94795.96YesYes065
75R:R:F237 R:R:T275 12.36867.78YesNo088
76R:R:T275 R:R:Y240 11.77013.75NoYes086
77R:R:D282 R:R:D63 31.86175.32YesYes099
78R:R:C279 R:R:D63 29.1234.67NoYes099
79R:R:C279 R:R:Y66 27.36124.03NoYes097
80R:R:F77 R:R:Y24 10.29956.19YesYes059
81R:R:F97 R:R:Y66 15.399210.32YesYes077
82B:B:K57 B:B:Q75 25.334413.56YesYes199
83B:B:Q75 B:B:W99 50.62847.67YesYes199
84B:B:W332 B:B:Y59 33.72084.82YesYes198
85B:B:F241 B:B:F253 10.22528.57YesYes366
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C110 R:R:Y55 8.06 2 No Yes 7 7 2 2
R:R:V137 R:R:Y55 3.79 2 No Yes 5 7 2 2
R:R:Y55 W:W:?1 6.23 2 Yes Yes 7 0 2 1
R:R:A106 W:W:?1 3.35 0 No Yes 6 0 2 1
R:R:C109 R:R:L196 4.76 0 No No 8 6 2 1
R:R:C110 W:W:?1 6.74 2 No Yes 7 0 2 1
R:R:S112 R:R:S200 6.52 0 No No 9 8 2 1
R:R:V113 W:W:?1 15.83 0 No Yes 6 0 2 1
R:R:A120 R:R:Y116 4 0 No Yes 7 8 2 1
R:R:H121 R:R:Y116 7.62 19 No Yes 6 8 2 1
R:R:Y116 W:W:?2 27.4 0 Yes Yes 8 0 1 0
R:R:V137 W:W:?1 6.33 2 No Yes 5 0 2 1
R:R:E145 W:W:?1 9.86 0 No Yes 7 0 2 1
R:R:F192 R:R:P193 5.78 2 No No 5 9 2 2
R:R:F192 R:R:L196 13.4 2 No No 5 6 2 1
R:R:F192 W:W:?1 3.88 2 No Yes 5 0 2 1
R:R:P193 W:W:?1 5.23 2 No Yes 9 0 2 1
R:R:L196 W:W:?2 7.35 0 No Yes 6 0 1 0
R:R:L199 W:W:?2 5.88 0 No Yes 5 0 1 0
R:R:S200 W:W:?2 7.98 0 No Yes 8 0 1 0
W:W:?1 W:W:?2 6.25 2 Yes Yes 0 0 1 0
R:R:G203 R:R:Y116 2.9 0 No Yes 4 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
62.50Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
50.00Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
9.09Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
8.33Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
7.69Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
7.14Single5O9HNDT95137275O9H-C5a1-NDT9513727
6.25Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
6.25Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
5.56Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218
5.00Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
4.55Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E51 R:R:Y55 14.59 2 No Yes 7 7 2 1
R:R:D114 R:R:E51 14.29 2 No No 8 7 2 2
R:R:A134 R:R:E51 4.53 2 No No 8 7 2 2
R:R:C110 R:R:Y55 8.06 2 No Yes 7 7 1 1
R:R:D114 R:R:Y55 6.9 2 No Yes 8 7 2 1
R:R:A134 R:R:Y55 5.34 2 No Yes 8 7 2 1
R:R:V137 R:R:Y55 3.79 2 No Yes 5 7 1 1
R:R:Y55 W:W:?1 6.23 2 Yes Yes 7 0 1 0
R:R:E145 R:R:I103 6.83 0 No No 7 7 1 2
R:R:I105 R:R:P193 3.39 0 No No 8 9 2 1
R:R:A106 W:W:?1 3.35 0 No Yes 6 0 1 0
R:R:C110 W:W:?1 6.74 2 No Yes 7 0 1 0
R:R:V113 W:W:?1 15.83 0 No Yes 6 0 1 0
R:R:Y116 W:W:?2 27.4 0 Yes Yes 8 0 2 1
R:R:V137 W:W:?1 6.33 2 No Yes 5 0 1 0
R:R:E145 W:W:?1 9.86 0 No Yes 7 0 1 0
R:R:F192 R:R:P193 5.78 2 No No 5 9 1 1
R:R:F192 R:R:L196 13.4 2 No No 5 6 1 2
R:R:F192 W:W:?1 3.88 2 No Yes 5 0 1 0
R:R:P193 W:W:?1 5.23 2 No Yes 9 0 1 0
R:R:L196 W:W:?2 7.35 0 No Yes 6 0 2 1
R:R:L199 W:W:?2 5.88 0 No Yes 5 0 2 1
R:R:S200 W:W:?2 7.98 0 No Yes 8 0 2 1
W:W:?1 W:W:?2 6.25 2 Yes Yes 0 0 0 1
R:R:L117 R:R:V113 2.98 0 No No 6 6 2 1
R:R:E145 R:R:T144 1.41 0 No No 7 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
70.00Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
47.06Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
41.67Single8K9LBMS-9861228K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
40.00Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
38.46Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
35.71Single5O9HNDT95137275O9H-C5a1-NDT9513727
35.00Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
33.33Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
33.33Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
28.57Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
23.53Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
23.53Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
23.53Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
22.22Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
21.43Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.43Single9K1CDHA9K1C-FFA1-DHA-Gi1/β1/γ2
20.00Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
18.75Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
15.79Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/β1/γ2
13.33Single9CM3Compound 1879CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.76Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
11.76Single8IYXYL-3658IYX-GPR34-YL-365
10.53Single8YYXLeukotriene e48YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9NS9Compound 1879NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
7.14Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.67Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
6.67Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
6.67Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.45Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.25Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
6.25Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.25Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.25Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
5.88Single7LJCMevidalen7LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
5.26Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
4.76Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.76Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
4.55Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.55Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.55Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
4.35Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.17Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.17Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
4.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
3.45Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
3.45Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
3.12Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone

PDB Summary
PDB 9JCQ
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo sapiens
Ligand -
Other Ligand(s) LPC
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.59
Date 2025-07-09
D.O.I. doi.org/10.1038/s41421-025-00807-y
Net Summary
Imin 3.05
Number of Linked Nodes 880
Number of Links 1087
Number of Hubs 165
Number of Links mediated by Hubs 623
Number of Communities 28
Number of Nodes involved in Communities 239
Number of Links involved in Communities 346
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 2430271
Length Of Smallest Path 3
Average Path Length 35.0542
Length of Longest Path 61
Minimum Path Strength 1.315
Average Path Strength 7.23815
Maximum Path Strength 27.25
Minimum Path Correlation 0.7
Average Path Correlation 0.988208
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 39.8158
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.2333
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_W_
PDB ResiduesW:W:?1 W:W:?2
Environment DetailsOpen EMBL-EBI Page
Code_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9JCQ_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRITSGIF 
ETKFQVDKV NFHMFDVGQ RDERRKWIQ CFNDVTAII FVVSSYNRL 
QEALNFKSI WNNRWLRTI SVILFLNKQ DLLAEKVLA GKSKIEDYF 
PEFARYTTP EDATPEPGE DPRVTRAKY FIRDEFLRI STASGDGRH 
YCYPHFTCV DTENRRFND CRDIIQRMH LRQYELLSA DAVRSMDNY 
KADDDSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JCQ_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JCQ_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JCQ_Chain_R
GCHVDSRVD HLFPPSLYI FVIGVGLPT NCLALWAAY RQVQQRNEL 
GVYLMNLSI ADLLYICTL PLWVDYFLH HDNWIHGPG SCKLFGFIF 
YTNIYISIA FLCCISVDR YLAVAHPLR FARLRRVKT AVAVSSVVW 
ATELGANSA PLFHDELFR DRYNHTFCF EKFPMEGWV AWMNLYRVF 
VGFLFPWAL MLLSYRGIL RAVRGSVST ERQEKAKIK RLALSLIAI 
VLVCFAPYH VLLLSRSAI YLGRPWDCG FEERVFSAY HSSLAFTSL 
NCVADPILY CLVNEGARS DVAKALHNL LRF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JCQ.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.