Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 7.15434
2A:A:H41 6.36426
3A:A:N50 7.12754149
4A:A:I56 4.79467
5A:A:F219 7.546508
6A:A:H220 7.8525417
7A:A:M221 4.6225138
8A:A:F222 8.342517
9A:A:Q227 6.038519
10A:A:R228 4.2225419
11A:A:E230 9.618519
12A:A:R231 5.446519
13A:A:K233 6.4475819
14A:A:W234 6.98619
15A:A:I235 4.6625419
16A:A:F238 10.4175409
17A:A:V247 4.205467
18A:A:V248 4.12407
19A:A:Y253 4.51408
20A:A:R265 6.74754149
21A:A:F273 5.1645159
22A:A:W277 8.6156156
23A:A:W281 6.35333615
24A:A:I288 7.21469
25A:A:F290 6.554569
26A:A:N292 5.4575469
27A:A:Q294 6.75476
28A:A:L297 4.045478
29A:A:I308 5.6875477
30A:A:F312 3.6525408
31A:A:F315 9.626576
32A:A:P321 4.204575
33A:A:E330 4.484223
34A:A:V334 4.22404
35A:A:Y339 7.878573
36A:A:F340 8.62667677
37A:A:R342 7.002574
38A:A:F345 6.925408
39A:A:Y360 10.5157768
40A:A:F363 10.818575
41A:A:T364 6.875469
42A:A:S366 6.2575468
43A:A:D368 4.9025469
44A:A:N371 6.55569
45A:A:R374 7.554564
46A:A:F376 5.91428
47A:A:I383 5.508528
48A:A:R385 6.045465
49A:A:H387 4.99428
50A:A:L388 6.0154238
51A:A:Y391 7.3575424
52B:B:L14 5.6225408
53B:B:I18 4.075457
54B:B:R22 7.0525456
55B:B:L30 6.03254185
56B:B:V40 5.55103
57B:B:H54 9.272539
58B:B:K57 10.026519
59B:B:Y59 9.544518
60B:B:W63 8.4475437
61B:B:L70 5.3325435
62B:B:D76 7.86439
63B:B:L79 5.6445117
64B:B:I80 9.16438
65B:B:I81 5.3485207
66B:B:W82 9.55639
67B:B:K89 6.17667639
68B:B:H91 6.64205
69B:B:I93 6.0654117
70B:B:L95 4.7265118
71B:B:W99 9.72667619
72B:B:Y105 4.3406
73B:B:N110 6.8875414
74B:B:Y111 6.148514
75B:B:V112 4.56408
76B:B:C114 3.7385118
77B:B:I123 4.13516
78B:B:Y124 5.137147116
79B:B:H142 7.24333619
80B:B:Y145 6.6125818
81B:B:F151 6.046519
82B:B:L152 5.2375443
83B:B:V158 5.32445
84B:B:S161 7.005419
85B:B:D163 5.85419
86B:B:L168 3.585446
87B:B:W169 9.29167618
88B:B:Q176 6.3625414
89B:B:T178 3.9025444
90B:B:F180 7.93547
91B:B:H183 9.942549
92B:B:D186 7.19833619
93B:B:V187 4.2525449
94B:B:L190 4.93445
95B:B:F199 8.18549
96B:B:V200 6.3025456
97B:B:S201 5.2625449
98B:B:C204 4.41167617
99B:B:D205 8.0625449
100B:B:S207 4.5425445
101B:B:K209 10.296546
102B:B:L210 7.2425455
103B:B:W211 10.52548
104B:B:F222 9.145458
105B:B:H225 9.08759
106B:B:D228 8.7875419
107B:B:I232 6.1075458
108B:B:F235 9.08754166
109B:B:P236 7.7854167
110B:B:F241 7.17756
111B:B:T243 6.6575458
112B:B:D247 7.884559
113B:B:T249 6.885456
114B:B:R251 9.9758
115B:B:F253 7.00667656
116B:B:D254 4.015409
117B:B:R256 10.0054199
118B:B:D258 8.5125457
119B:B:L261 5.15754185
120B:B:Y264 5.515605
121B:B:C271 4.22415
122B:B:I273 4.955406
123B:B:F278 7.4954167
124B:B:R283 10.094109
125B:B:L285 5.6925406
126B:B:Y289 6.25167617
127B:B:D290 7.37416
128B:B:N295 6.4575416
129B:B:V296 3.5275405
130B:B:D298 9.1854109
131B:B:H311 9.346599
132B:B:R314 12.67518
133B:B:V315 3.5575497
134B:B:V327 4.6275406
135B:B:T329 5.43498
136B:B:W332 11.7714719
137B:B:D333 11.27499
138B:B:F335 8.615494
139B:B:K337 7.76596
140B:B:W339 11.145499
141G:G:L19 6.81409
142G:G:R27 5.846558
143G:G:L37 1.384187
144G:G:Y40 9.08254166
145G:G:D48 7.51409
146G:G:L51 6.32754106
147G:G:V54 3.895406
148G:G:F61 5.35714738
149R:R:Y24 10.8885178
150R:R:F28 9.654177
151R:R:N35 7.782509
152R:R:E51 9.18333626
153R:R:Y55 5.64833627
154R:R:W73 5.6475406
155R:R:Y76 9.29686
156R:R:Y77 10.2425485
157R:R:W83 5.974508
158R:R:F95 5.8954125
159R:R:F97 5.6125407
160R:R:N100 6.6075409
161R:R:Y102 7.7554127
162R:R:F107 7.752527
163R:R:D114 9.418528
164R:R:R115 5.43667629
165R:R:Y116 4.5685248
166R:R:V119 5.5454238
167R:R:P122 5.43428
168R:R:L123 6.0275425
169R:R:F125 10.1825425
170R:R:P126 5.9275425
171R:R:R129 5.23607
172R:R:W142 6.846529
173R:R:E145 4.224127
174R:R:N149 6.755126
175R:R:F167 10.9683683
176R:R:E170 7.396586
177R:R:Y172 8.022585
178R:R:V187 5.1625406
179R:R:F191 6.705409
180R:R:P194 2.685409
181R:R:M199 7.2975404
182R:R:Y202 8.1725409
183R:R:S212 3.87465
184R:R:S214 6.2563
185R:R:C215 4.0575462
186R:R:E219 4.2025465
187R:R:Y238 6.114508
188R:R:Y241 5.82571707
189R:R:R248 10.085485
190R:R:F272 5.5475484
191R:R:Y275 6.884586
192R:R:H276 9.1575485
193R:R:N285 9.645429
194R:R:D289 10.57429
195R:R:Y293 6.314529
196R:R:C294 2.575406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I93 B:B:P94 40.29353.39YesNo075
2B:B:K78 B:B:P94 40.40215.02NoNo085
3B:B:D76 B:B:K78 41.15968.3YesNo098
4B:B:D76 B:B:S74 15.72648.83YesNo399
5B:B:H54 B:B:S74 15.256412.55YesNo399
6B:B:H54 B:B:W82 13.28364.23YesYes399
7A:A:K34 R:R:R129 99.85399.9NoYes047
8A:A:K34 B:B:L55 99.79517.05NoNo046
9B:B:D76 B:B:L55 50.394810.86YesNo396
10A:A:R42 A:A:Y37 51.199716.46NoYes094
11A:A:F222 A:A:R42 51.1124.28YesNo079
12A:A:F219 A:A:H41 28.8295.66YesYes086
13A:A:H41 A:A:I383 28.73265.3YesYes268
14A:A:H387 A:A:I383 29.6886.63YesYes288
15A:A:H387 A:A:Y391 82.31044.36YesYes284
16A:A:Y391 R:R:D114 82.62512.64YesYes248
17R:R:D114 R:R:E51 89.206516.89YesYes286
18R:R:E51 R:R:P130 98.882711YesNo265
19R:R:P130 R:R:R129 1002.88NoYes057
20A:A:F219 A:A:L43 28.45117.31YesNo087
21A:A:I245 A:A:L43 25.85.71NoNo1377
22A:A:F222 B:B:W99 50.461222.05YesYes179
23A:A:W281 B:B:W332 15.85663.75YesYes159
24A:A:F290 A:A:N371 48.309610.87YesYes699
25A:A:F290 A:A:I375 25.78345.02YesNo098
26A:A:I245 A:A:I375 25.84855.89NoNo078
27A:A:F290 A:A:I288 71.17213.77YesYes699
28A:A:I288 A:A:Y360 71.56743.63YesYes698
29A:A:D381 A:A:Y360 34.037411.49NoYes688
30A:A:D381 R:R:S212 34.13075.89NoYes685
31A:A:Q384 R:R:S212 69.07332.89NoYes065
32A:A:Q384 R:R:P122 52.61633.16NoYes068
33A:A:H387 R:R:P122 52.65484.58YesYes288
34A:A:Y360 R:R:S214 38.38475.09YesYes683
35R:R:S212 R:R:S214 34.49463.26YesYes653
36B:B:W332 B:B:Y59 21.186413.5YesYes198
37B:B:K57 B:B:W332 19.641517.4YesYes199
38A:A:F246 A:A:V248 10.43283.93NoYes097
39A:A:L291 A:A:V248 25.42652.98NoYes087
40A:A:F363 A:A:L291 26.07874.87YesNo058
41A:A:F363 A:A:Q294 33.855310.54YesYes756
42A:A:L297 A:A:Q294 39.05353.99YesYes786
43A:A:L297 A:A:S251 64.33023YesNo089
44A:A:L296 A:A:S251 90.30536.01NoNo069
45A:A:D295 A:A:L296 90.94675.43NoNo096
46A:A:C365 A:A:D295 91.58816.22NoNo089
47A:A:C365 A:A:D368 92.22936.22NoYes089
48A:A:D368 A:A:T364 46.32585.78YesYes699
49A:A:F290 A:A:T364 47.28945.19YesYes699
50A:A:D368 A:A:N371 46.51934.04YesYes699
51A:A:F345 A:A:V248 13.68967.87YesYes087
52A:A:K300 A:A:S251 25.3463.06NoNo099
53A:A:L297 A:A:Y253 24.10454.69YesYes088
54A:A:K300 A:A:Y253 24.05133.58NoYes098
55A:A:I308 A:A:Y253 27.32357.25YesYes078
56A:A:F312 A:A:F340 10.4326.43YesYes087
57A:A:F340 A:A:I308 15.61523.77YesYes777
58A:A:F273 A:A:W277 11.7564.01YesYes1596
59A:A:W281 B:B:D290 21.35738.93YesYes156
60B:B:R314 B:B:W332 24.248826.99YesYes189
61B:B:D290 B:B:R314 15.114113.1YesYes168
62A:A:V301 A:A:V334 13.0444.81NoYes074
63A:A:V301 A:A:Y253 19.56362.52NoYes078
64A:A:Q384 R:R:V119 16.69564.3NoYes068
65A:A:Y391 R:R:R115 26.14613.09YesYes249
66A:A:L393 R:R:R115 22.72166.07NoYes089
67A:A:L388 A:A:L393 14.10724.15YesNo088
68R:R:D114 R:R:L52 13.37278.14YesNo287
69R:R:L52 R:R:R115 13.33744.86NoYes279
70R:R:L66 R:R:N100 12.16689.61NoYes079
71R:R:N100 R:R:S62 12.64162.98YesNo098
72R:R:S62 R:R:W142 12.75134.94NoYes289
73R:R:F107 R:R:W142 13.10387.02YesYes279
74R:R:F107 R:R:Y55 13.9753.09YesYes277
75B:B:I93 B:B:Y124 36.44124.84YesYes1176
76B:B:V112 B:B:Y124 34.27463.79YesYes086
77B:B:V112 B:B:Y105 34.60523.79YesYes086
78B:B:H62 B:B:Y105 34.28673.27NoYes066
79B:B:H62 B:B:R150 34.054315.8NoNo466
80B:B:L192 B:B:R150 34.02636.07NoNo456
81B:B:L192 B:B:V158 33.04612.98NoYes455
82B:B:F199 B:B:V158 31.63047.87YesYes495
83B:B:F199 B:B:W211 40.475712.03YesYes498
84B:B:K209 B:B:W211 20.317911.6YesYes468
85B:B:K209 B:B:T221 19.46212.01YesNo467
86B:B:T221 G:G:E22 19.37567.06NoNo079
87G:G:E22 G:G:L19 38.400413.25NoYes099
88B:B:C218 B:B:W211 19.8066.53NoYes458
89B:B:C218 G:G:Q18 19.67973.05NoNo059
90G:G:E22 G:G:Q18 19.292611.47NoNo099
91B:B:I18 G:G:L19 32.77944.28YesYes079
92B:B:I18 B:B:R22 16.59855.01YesYes576
93B:B:I18 G:G:R27 15.76863.76YesYes578
94B:B:D258 B:B:R22 14.683913.1YesYes576
95B:B:D258 G:G:R27 14.66837.15YesYes578
96B:B:R314 B:B:T274 11.025111.64YesNo188
97B:B:S275 B:B:T274 12.90043.2NoNo088
98B:B:L318 B:B:S275 12.5826.01NoNo068
99B:B:L318 B:B:T329 11.62374.42NoYes068
100B:B:K57 B:B:Q75 19.897510.85YesNo199
101B:B:Q75 B:B:Y59 19.821814.65NoYes198
102B:B:G162 B:B:Y145 11.945510.14NoYes198
103B:B:G162 B:B:S161 16.27563.71NoYes199
104B:B:H142 B:B:S161 15.77813.95YesYes199
105B:B:C148 B:B:L190 11.13253.17NoYes065
106B:B:C121 B:B:T159 10.50513.38NoNo089
107B:B:C121 B:B:C149 11.27033.64NoNo088
108B:B:C149 B:B:T102 11.16063.38NoNo088
109B:B:D258 B:B:F222 28.24765.97YesYes578
110B:B:F222 B:B:F241 17.729611.79YesYes586
111B:B:C271 B:B:D290 34.04143.11YesYes156
112B:B:C271 B:B:Y289 32.70184.03YesYes157
113B:B:W297 B:B:Y289 25.551410.61NoYes187
114B:B:W297 B:B:Y264 25.13538.68NoYes085
115B:B:L285 B:B:Y264 14.92795.86YesYes065
116B:B:F278 B:B:L285 13.576112.18YesYes076
117R:R:R115 R:R:Y293 50.77088.23YesYes299
118R:R:D289 R:R:Y293 24.38475.75YesYes299
119R:R:L108 R:R:Y293 23.82094.69NoYes289
120R:R:L108 R:R:N285 23.55194.12NoYes289
121R:R:N285 R:R:Y238 45.478616.28YesYes098
122R:R:L101 R:R:Y238 36.07515.86NoYes078
123R:R:L101 R:R:Y102 12.06633.52NoYes077
124R:R:D289 R:R:N285 23.577913.46YesYes299
125R:R:L101 R:R:Y241 23.93663.52NoYes077
126R:R:Y241 R:R:Y275 20.72557.94YesYes076
127B:B:Q75 B:B:W99 39.78095.48NoYes199
128B:B:C148 B:B:T102 11.05183.38NoNo068
129A:A:Y37 B:B:L55 49.37054.69YesNo346
130B:B:F199 B:B:L190 10.16426.09YesYes495
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ZFA
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Xenopus tropicalis
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.96
Date 2025-02-26 
D.O.I. 10.1016/j.cell.2024.12.001
Net Summary
Imin 2.88
Number of Linked Nodes 860
Number of Links 1077
Number of Hubs 196
Number of Links mediated by Hubs 688
Number of Communities 25
Number of Nodes involved in Communities 297
Number of Links involved in Communities 443
Path Summary
Number Of Nodes in MetaPath 131
Number Of Links MetaPath 130
Number of Shortest Paths 2870880
Length Of Smallest Path 3
Average Path Length 32.6396
Length of Longest Path 63
Minimum Path Strength 1.12
Average Path Strength 7.1162
Maximum Path Strength 22.75
Minimum Path Correlation 0.7
Average Path Correlation 0.987115
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 38.4423
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.4258
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • response to pH   • response to abiotic stimulus   • response to acidic pH
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ZFA_Chain_A
IEKQLQKDK QVYRATHRL LLLGASGKS TIVKQMRIH VVTSGIFET 
KFQVDKVNF HMFDVGQRD ERRKWIQCF NDVTAIIFV VSSYNRLQE 
ALNFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAGK SKIEDYFPE 
FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST ASGDGRHYC 
YPHFTCVDT ENRRFNDCR DIIQRMHLR QYELLTLSA EDKAAVERS 
KMDNYKADD DSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8ZFA_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8ZFA_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtA0A6I8PUB9
Sequence
>8ZFA_Chain_R
SVLPPSLYA LVFTLGLPA NLLALWAAW LQVRKGREL GVYLLNLSL 
SDLLLICAL PPWTDYYLR RDVWGYGPG ACRLFGFVF YTNLYVGAA 
FLSCVSADR YLAVAHPLR FPGARPIRS AAAVSALIW MLELAANAP 
PLHRDRYNH TFCYESYPL SGRGAALAN VGRVLAGFL LPWGVMMLC 
YAGLLRALR GSASCEQRE RRRVRRLAL GLPCVALLC YGPYHALLL 
LRSLVFLGG CALEERLFP AYHASLALA TLNCLADPA LYCLACPGA 
RGEVAKV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-2610.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-2610.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-2610.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-2610.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-2610.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-2610.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-2610.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-2610.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-2610.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-2610.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-2610.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-2610.1016/j.cell.2024.12.001
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-2610.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-2610.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-2610.1016/j.cell.2024.12.001
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZFJAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.12024-08-07To be published
8ZFJ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.12024-08-07To be published
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-2610.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-2610.1016/j.cell.2024.12.001




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