Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L30 3.386535
2A:A:L41 5.0125416
3A:A:R42 7.618529
4A:A:L46 4.74428
5A:A:N50 6.75519
6A:A:F212 7.1775419
7A:A:F219 5.84143718
8A:A:H220 11.46527
9A:A:M221 4.0775418
10A:A:F222 10.2167627
11A:A:Q227 5.2425429
12A:A:K233 6.194529
13A:A:W234 6.27667629
14A:A:C237 4.345628
15A:A:F238 7.44714729
16A:A:I244 4.355628
17A:A:I245 3.4725417
18A:A:F246 3.402509
19A:A:V247 4.145417
20A:A:Y253 9.21408
21A:A:R265 9.81419
22A:A:L270 5.152526
23A:A:F273 4.75729
24A:A:I276 3.64428
25A:A:W277 9.15667626
26A:A:W281 7.12667625
27A:A:L282 6.3425429
28A:A:L289 4.53429
29A:A:F290 5.14143719
30A:A:L291 3.645428
31A:A:N292 4.92167619
32A:A:F312 4.178528
33A:A:F315 12.378526
34A:A:P326 3.4175401
35A:A:D331 6.5954114
36A:A:V334 6.754114
37A:A:F340 7.94333627
38A:A:R342 7.3925404
39A:A:E344 6.14405
40A:A:F345 5.52728
41A:A:R356 7.518512
42A:A:C359 3.4325425
43A:A:Y360 8.744518
44A:A:F363 10.54425
45A:A:T364 5.248519
46A:A:D368 4.01333619
47A:A:N371 7.835419
48A:A:R374 6.596514
49A:A:I375 3.93419
50A:A:F376 4.4825818
51A:A:D381 6.208518
52A:A:I382 5.2516
53A:A:I383 3.866518
54A:A:L384 3.1516
55A:A:Q385 5.71143715
56A:A:L388 4.082518
57A:A:Y391 7.81143714
58B:B:L7 5.2675408
59B:B:R22 6.685456
60B:B:D27 5.4375408
61B:B:L30 3.63405
62B:B:T34 3.7275405
63B:B:I37 5.12402
64B:B:V40 4.9523
65B:B:M45 3.286524
66B:B:H54 8.85167639
67B:B:L55 10.7175406
68B:B:K57 6.936529
69B:B:Y59 13.9225428
70B:B:M61 4.945436
71B:B:W63 5.9737
72B:B:L70 4.08333635
73B:B:V71 4.3675468
74B:B:Q75 9.4575429
75B:B:L79 3.725467
76B:B:I80 8.64438
77B:B:I81 3.98567
78B:B:W82 10.9386739
79B:B:S84 4.4125435
80B:B:K89 7.18714739
81B:B:H91 4.784565
82B:B:I93 5.3475467
83B:B:L95 4.6575468
84B:B:W99 8.92143729
85B:B:M101 5.2425429
86B:B:N110 7.925424
87B:B:Y111 6.146524
88B:B:V112 4.7575468
89B:B:C114 4.125468
90B:B:L117 3.93667629
91B:B:N119 4.595429
92B:B:C121 3.7375428
93B:B:I123 3.48667626
94B:B:Y124 5.55143766
95B:B:L126 4.6925465
96B:B:V133 5.0525464
97B:B:E138 3.8225406
98B:B:L139 5.766509
99B:B:H142 6.98729
100B:B:Y145 5.83875828
101B:B:C149 4.32428
102B:B:F151 5.73167629
103B:B:L152 3.96543
104B:B:I157 4.748527
105B:B:V158 4.29445
106B:B:T159 4.16333629
107B:B:D163 8.7575429
108B:B:L168 3.285646
109B:B:W169 8.22286728
110B:B:T173 4.7425485
111B:B:F180 7.54833647
112B:B:H183 8.345649
113B:B:D186 7.0025429
114B:B:V187 4.978549
115B:B:L190 4.63445
116B:B:L192 4.6725445
117B:B:R197 7.62475
118B:B:L198 6.69473
119B:B:F199 6.725649
120B:B:V200 8.9375456
121B:B:S201 5.2625449
122B:B:C204 5.41427
123B:B:D205 7.385449
124B:B:S207 4.192545
125B:B:K209 7.958546
126B:B:L210 6.5875405
127B:B:W211 9.23167648
128B:B:D212 7.606579
129B:B:Q220 6.49457
130B:B:F222 7.62558
131B:B:H225 7.41659
132B:B:D228 8.2125429
133B:B:I232 5.8625458
134B:B:F235 6.89626
135B:B:P236 6.0025427
136B:B:F241 6.75286756
137B:B:T243 4.69558
138B:B:D247 7.365409
139B:B:T249 6.185456
140B:B:R251 13.2075458
141B:B:F253 11.0475456
142B:B:D254 7.0125459
143B:B:D258 7.565457
144B:B:Q259 5.54456
145B:B:L261 5.815405
146B:B:Y264 6.13833625
147B:B:I269 5.16424
148B:B:C271 3.87425
149B:B:F278 6.81333627
150B:B:R283 7.35833629
151B:B:L285 6.495426
152B:B:L286 4.36627
153B:B:Y289 7.92167627
154B:B:D290 6.9675426
155B:B:N295 8.235426
156B:B:K301 5.29405
157B:B:R304 7.175425
158B:B:V307 3.56523
159B:B:H311 7.25667629
160B:B:R314 11.65528
161B:B:L318 4.455626
162B:B:M325 5.318535
163B:B:V327 6.0725426
164B:B:W332 11.5471729
165B:B:D333 9.1125429
166B:B:F335 6.66404
167B:B:L336 4.5875437
168B:B:K337 6.4175426
169B:B:I338 3.8525435
170B:B:W339 8.82167629
171G:G:R27 6.6025408
172G:G:L50 3.64429
173G:G:L51 4.39426
174G:G:N59 6.64439
175G:G:P60 7.8675439
176G:G:F61 4.50556938
177R:R:V11 4.67513
178R:R:D16 8.69515
179R:R:P20 5.904515
180R:R:Y24 7.11667619
181R:R:V27 3.87407
182R:R:I28 4.475407
183R:R:N35 8.16519
184R:R:N50 7.09417
185R:R:L52 4.54333618
186R:R:V54 3.2825405
187R:R:Y55 5.87143717
188R:R:M57 2.9525405
189R:R:L59 4.7725419
190R:R:D63 7.35419
191R:R:I67 4.0525416
192R:R:L70 7.5975418
193R:R:W73 6.25857717
194R:R:Y76 9.32167616
195R:R:F77 7.33167615
196R:R:D81 6.752514
197R:R:W83 7.41375819
198R:R:H85 3.99517
199R:R:F93 5.752516
200R:R:F95 7.49754126
201R:R:F97 8.38333617
202R:R:Y98 7.6375415
203R:R:Y102 8.62407
204R:R:I103 5.4417
205R:R:S104 3.7225419
206R:R:I105 4.235418
207R:R:F107 6.445618
208R:R:L108 5.484518
209R:R:I111 4.372519
210R:R:D114 8.412518
211R:R:R115 6.356519
212R:R:Y116 5.934518
213R:R:L123 4.0375416
214R:R:R129 5.6225417
215R:R:R130 7.6454106
216R:R:S138 4.295417
217R:R:W142 8.2775419
218R:R:N149 4.09417
219R:R:S150 2.66754124
220R:R:P152 3.3775403
221R:R:Y163 10.315413
222R:R:H165 6.61411
223R:R:F167 8.125611
224R:R:F169 5.77404
225R:R:E170 11.755414
226R:R:F172 5.46333615
227R:R:M174 5.352511
228R:R:W177 12.0425401
229R:R:M181 3.985414
230R:R:N182 7.124515
231R:R:R185 7.05415
232R:R:V186 5.6925414
233R:R:M197 5.0475417
234R:R:Y201 5.71833618
235R:R:S211 3.8075415
236R:R:S213 7.51413
237R:R:T214 5.89413
238R:R:I230 4.3075417
239R:R:F237 5.54333618
240R:R:Y240 5.988506
241R:R:H241 10.516518
242R:R:L244 6.214515
243R:R:R247 7.85833614
244R:R:Y251 5.28513
245R:R:L252 4.0875416
246R:R:F260 6.08401
247R:R:E261 6.63414
248R:R:V264 4.78414
249R:R:F265 8.655614
250R:R:H269 9.51333615
251R:R:N278 6.458519
252R:R:D282 6.93833619
253R:R:Y286 6.53667619
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:S334 11.4532.79YesNo094
2B:B:F335 B:B:S334 11.58063.96YesNo044
3B:B:F335 R:R:Q47 1003.51YesNo046
4R:R:Q47 R:R:R44 99.97144.67NoNo064
5R:R:D296 R:R:R44 99.883713.1NoNo044
6R:R:A41 R:R:D296 99.85431.54NoNo074
7R:R:A41 R:R:C287 99.76541.81NoNo078
8R:R:A38 R:R:C287 99.73553.61NoNo098
9R:R:A38 R:R:S60 99.70563.42NoNo098
10R:R:N35 R:R:S60 93.66942.98YesNo098
11R:R:D63 R:R:N35 75.219516.16YesYes199
12R:R:D282 R:R:D63 78.24452.66YesYes199
13R:R:D282 R:R:Y286 64.88883.45YesYes199
14R:R:I111 R:R:Y286 20.9234.84YesYes199
15R:R:L56 R:R:Y286 19.10213.52NoYes189
16R:R:L52 R:R:L56 18.9764.15YesNo188
17A:A:Y391 R:R:L52 51.7468.21YesYes148
18A:A:N387 A:A:Y391 50.13819.3NoYes184
19A:A:I383 A:A:N387 49.84984.25YesNo188
20A:A:I383 A:A:L41 40.97462.85YesYes186
21A:A:F219 A:A:L41 40.69268.53YesYes186
22R:R:I111 R:R:L52 19.01364.28YesYes198
23R:R:R115 R:R:Y286 23.77865.14YesYes199
24R:R:L52 R:R:R115 19.19692.43YesYes189
25B:B:W332 B:B:Y59 48.195414.47YesYes298
26A:A:C237 B:B:Y59 46.74958.06YesYes288
27A:A:F219 A:A:I375 26.00642.51YesYes189
28A:A:W281 B:B:W332 14.43374.69YesYes259
29A:A:N279 A:A:W281 11.51283.39NoYes285
30A:A:F212 A:A:F219 10.527115YesYes198
31A:A:C237 B:B:L117 22.16193.17YesYes289
32A:A:K293 A:A:N292 11.77455.6NoYes199
33A:A:F290 A:A:I375 23.23156.28YesYes199
34A:A:F290 A:A:T364 10.13226.49YesYes199
35A:A:C237 B:B:M101 22.20024.86YesYes289
36B:B:M101 B:B:Y145 22.0278.38YesYes298
37B:B:L117 B:B:Y145 23.92783.52YesYes298
38B:B:G162 B:B:Y145 25.70064.35NoYes298
39B:B:G162 B:B:S161 27.50133.71NoNo299
40A:A:K233 B:B:Y145 26.43463.58YesYes298
41A:A:K233 B:B:D228 25.48588.3YesYes299
42B:B:C271 B:B:D290 13.18856.22YesYes256
43B:B:C271 B:B:Y289 12.07884.03YesYes257
44B:B:W297 B:B:Y289 10.73564.82NoYes287
45B:B:W297 B:B:Y264 10.662712.54NoYes285
46B:B:D254 B:B:L261 17.375213.57YesYes095
47B:B:D254 B:B:Q259 15.95665.22YesYes596
48B:B:Q259 B:B:R22 12.97558.18YesYes566
49B:B:D258 B:B:R22 10.988310.72YesYes576
50B:B:K337 B:B:W339 13.05295.8YesYes269
51B:B:M45 B:B:W339 18.90023.49YesYes249
52B:B:M45 G:G:L50 17.01512.83YesYes249
53B:B:S279 G:G:L50 29.78483NoYes299
54B:B:S279 G:G:D48 10.82275.89NoNo299
55G:G:D48 G:G:L51 10.38126.79NoYes296
56B:B:D333 B:B:F335 84.81589.55YesYes094
57B:B:D333 B:B:H311 25.77877.56YesYes299
58B:B:H311 B:B:T329 19.13056.85YesNo098
59B:B:L318 B:B:T329 12.49784.42YesNo068
60B:B:H142 B:B:S161 26.374516.74YesNo299
61B:B:H142 B:B:T159 15.41852.74YesYes299
62B:B:C149 B:B:T159 10.93625.07YesYes289
63B:B:C149 B:B:T102 10.62926.76YesNo088
64B:B:C148 B:B:T102 10.43873.38NoNo068
65B:B:D228 B:B:S227 26.89382.94YesNo096
66B:B:D247 B:B:S227 26.6132.94YesNo096
67B:B:D247 B:B:S245 12.33934.42YesNo099
68B:B:H225 B:B:S245 12.184915.34YesNo099
69B:B:H225 B:B:T243 23.08235.48YesYes598
70B:B:D247 B:B:T249 14.002213.01YesYes096
71B:B:H225 B:B:T249 12.20022.74YesYes596
72B:B:F241 B:B:T243 13.5312.59YesYes568
73B:B:L198 B:B:L210 17.07485.54YesYes035
74B:B:S279 B:B:S281 18.52053.26NoNo299
75B:B:G282 B:B:S281 18.09423.71NoNo299
76B:B:F235 B:B:G282 13.90416.02YesNo269
77B:B:F235 G:G:L37 12.06116.09YesNo267
78B:B:L261 G:G:L37 11.87282.77YesNo057
79B:B:D333 B:B:S331 59.05637.36YesNo299
80B:B:N313 B:B:S331 59.61342.98NoNo079
81B:B:N313 B:B:W332 59.6147.91NoYes079
82R:R:I67 R:R:N35 18.21024.25YesYes169
83R:R:I28 R:R:I67 18.33235.89YesYes076
84R:R:I28 R:R:L70 17.99448.56YesYes078
85R:R:F97 R:R:L70 11.9222.44YesYes178
86R:R:D282 R:R:N278 18.944413.46YesYes199
87R:R:F237 R:R:N278 22.10918.46YesYes189
88R:R:F237 R:R:H241 19.95786.79YesYes188
89R:R:H241 R:R:Y240 12.79176.53YesYes086
90R:R:M174 R:R:Y251 11.88584.79YesYes113
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z3M
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.9
Date 2025-04-23
D.O.I. To be published
Net Summary
Imin 2.43
Number of Linked Nodes 870
Number of Links 1216
Number of Hubs 253
Number of Links mediated by Hubs 870
Number of Communities 13
Number of Nodes involved in Communities 376
Number of Links involved in Communities 632
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 2941205
Length Of Smallest Path 3
Average Path Length 28.6437
Length of Longest Path 50
Minimum Path Strength 1.315
Average Path Strength 6.0171
Maximum Path Strength 22.0867
Minimum Path Correlation 0.7
Average Path Correlation 0.988048
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 43.66
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.2456
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • Ras protein signal transduction   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8Z3M_Chain_A
EKAEKIEKQ LQKDKQVYR TRLLLLGAS GKSTIVKQM RIHTSGIFE 
TKFQVDKVN FHMFDVGQR DERRKWIQC FNDVTAIIF VVSSYNRLQ 
EALNFKSIW NNRWLRTIS VILFLNKQD LLAEKVLAG KSKIEDYFP 
EFARYTTPE DATPEPGED PRVTRAKYF IREFISTAS GDGRHCYPH 
FTCVDTENR RFNDCDIIM LRYLTLSAD AVRSMRLDN YKADDDKVD 
ISAIKLQNE NV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8Z3M_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8Z3M_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>8Z3M_Chain_R
CHVDSRVDH LFPPSLYIV IGVGLPTNC LALWAAYRQ VQQRNELGY 
LMLSIADLY ICTLPWVDY FHHDNWIHG PGSCKLFFI FYTNIYISI 
AFLCCIVDR YLAVAHPLR FRLRRVTVA VSSVVWATE LGANSAPLF 
HDELFRDRY NHTCFEKFP MEGWVAWMN LYRFVGFFP WAMLSYRLR 
VRGSVSTER QEKAKIKLA LSLAIVLVC FAPYHVLLS RSAIYGRPW 
DCGFEERVF SAYHSSAFT SLNCVDPIY LVNEGARSD AKAFVNLLL 
GSAKAFVLL LGIARILLL ALCV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z3M.zip



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