Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P22 6.77505
2R:R:Y26 5.0625408
3R:R:L54 4.3407
4R:R:V56 3.2775426
5R:R:Y57 5.914557
6R:R:M59 3.6025405
7R:R:D65 6.3375409
8R:R:Y68 6.528505
9R:R:W75 10.585616
10R:R:Y78 7.704515
11R:R:W85 8.85857719
12R:R:F99 10.918516
13R:R:N102 5.5325408
14R:R:Y104 8.47407
15R:R:F109 8.915437
16R:R:Y118 5.5775488
17R:R:H123 5.355486
18R:R:F127 4.325405
19R:R:V133 2.93424
20R:R:W144 7.7675439
21R:R:E147 3.055407
22R:R:H167 6.93403
23R:R:C170 7.935419
24R:R:F171 9.285404
25R:R:F174 7.2275404
26R:R:W179 10.4733603
27R:R:F192 6.272578
28R:R:W196 7.0575405
29R:R:Y203 5.37508
30R:R:F239 8.478579
31R:R:Y242 8.115407
32R:R:H243 7.175408
33R:R:R249 9.465405
34R:R:F267 8.07444
35R:R:H271 6.265404
36R:R:D284 8.4225469
37R:R:D298 5.6575405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F174 R:R:V13 11.04692.62YesNo044
2R:R:D83 R:R:F267 12.89067.17NoYes444
3R:R:D83 R:R:H82 11.44881.26NoNo044
4R:R:F267 R:R:H271 21.76736.79YesYes044
5R:R:F79 R:R:H271 12.47869.05NoYes044
6R:R:F21 R:R:P22 10.09245.78NoYes065
7R:R:P22 R:R:P23 16.77385.84YesNo056
8R:R:A275 R:R:P22 23.21413.74NoYes045
9R:R:E172 R:R:F169 14.32737NoNo052
10R:R:E172 R:R:Y78 15.48784.49NoYes055
11R:R:W75 R:R:Y78 21.01387.72YesYes165
12R:R:F99 R:R:W75 33.422128.06YesYes166
13R:R:F99 R:R:Y26 14.85484.13YesYes068
14R:R:A275 R:R:Y26 24.92724NoYes048
15R:R:F99 R:R:Y68 55.3258.25YesYes065
16R:R:S278 R:R:Y26 13.97075.09NoYes068
17R:R:S278 R:R:Y68 17.58776.36NoYes065
18R:R:C281 R:R:Y68 67.29134.03NoYes085
19R:R:C281 R:R:D65 67.06526.22NoYes089
20R:R:D65 R:R:N37 15.01566.73YesNo099
21R:R:N37 R:R:P285 10.614913.03NoNo099
22R:R:S278 R:R:V29 14.09636.46NoNo067
23R:R:I69 R:R:V29 12.11194.61NoNo057
24R:R:I69 R:R:L34 10.117611.42NoNo056
25R:R:D284 R:R:D65 64.83477.98YesYes099
26R:R:D284 R:R:L110 1006.79YesNo698
27R:R:L110 R:R:Y288 99.83428.21NoNo089
28R:R:I113 R:R:Y288 45.68474.84NoNo089
29R:R:I113 R:R:R117 44.97145.01NoNo089
30R:R:L54 R:R:R117 53.63714.86YesNo079
31R:R:D116 R:R:L54 46.62924.07NoYes087
32R:R:D116 R:R:Y57 39.85738.05NoYes587
33R:R:A136 R:R:Y57 36.67245.34NoYes077
34R:R:A136 R:R:V56 35.37635.09NoYes076
35R:R:V48 R:R:V56 28.54423.21NoYes256
36R:R:M59 R:R:V48 27.57964.56YesNo055
37R:R:M59 R:R:Y45 22.01352.39YesNo051
38R:R:R49 R:R:Y45 20.596811.32NoNo061
39R:R:R46 R:R:R49 19.17016.4NoNo056
40R:R:D298 R:R:R46 17.72333.57YesNo055
41R:R:R249 R:R:Y270 28.418614.4YesNo054
42R:R:Y242 R:R:Y270 40.82698.94YesNo074
43R:R:H243 R:R:Y242 43.04735.44YesYes087
44R:R:F192 R:R:H243 35.19047.92YesYes088
45R:R:F192 R:R:F239 31.68898.57YesYes789
46R:R:F239 R:R:N280 45.3138.46YesNo099
47R:R:D284 R:R:N280 47.57369.42YesNo099
48R:R:H271 R:R:Y270 24.34945.44YesNo044
49R:R:N102 R:R:Y68 20.88328.14YesYes085
50R:R:I105 R:R:N102 13.64924.25NoYes068
51R:R:I105 R:R:W144 10.68529.4NoYes069
52R:R:H87 R:R:W85 15.01564.23NoYes079
53R:R:H87 R:R:I86 13.55876.63NoNo073
54R:R:H81 R:R:I86 12.09182.65NoNo043
55R:R:H81 R:R:N84 10.61496.38NoNo044
56R:R:F171 R:R:Y100 18.19054.13YesNo045
57R:R:F171 R:R:P154 20.4168.67YesNo046
58R:R:L155 R:R:P154 12.23251.64NoNo046
59R:R:L274 R:R:Y242 16.768811.72NoYes057
60R:R:H243 R:R:Y104 11.14749.8YesYes087
61R:R:I103 R:R:Y104 13.44828.46NoYes077
62R:R:R187 R:R:Y104 10.936413.38NoYes057
63R:R:E147 R:R:Y104 13.33272.24YesYes077
64R:R:M199 R:R:S114 10.61496.13NoNo079
65R:R:S114 R:R:Y203 49.19625.09NoYes098
66R:R:L231 R:R:Y203 48.66874.69NoYes078
67R:R:L231 R:R:Y288 53.521512.89NoNo079
68R:R:C202 R:R:S114 39.34995.16NoNo069
69R:R:A122 R:R:Y118 15.7396.67NoYes868
70R:R:C202 R:R:Y118 36.78794.03NoYes068
71R:R:H123 R:R:Y118 14.4638.71YesYes868
72R:R:F127 R:R:H123 10.61496.79YesYes056
73R:R:M176 R:R:R249 20.06436.2NoYes035
74R:R:M176 R:R:Y253 16.296610.78NoNo033
75R:R:F192 R:R:W196 10.36875.01YesYes085
76R:R:A122 R:R:A209 14.84481.79NoNo065
77R:R:A209 R:R:V121 13.38291.7NoNo058
78R:R:V121 R:R:V210 11.9061.6NoNo088
79R:R:F79 R:R:Y78 12.041610.32NoYes045
80R:R:F99 R:R:L274 17.32644.87YesNo065
81R:R:P154 R:R:W179 11.76534.05NoYes063
82R:R:F99 R:R:Y100 13.28249.28YesNo165
83R:R:W75 R:R:W85 20.792713.12YesYes169
84R:R:F239 R:R:I103 13.32268.79YesNo097
85R:R:R117 R:R:Y203 10.15778.23NoYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ZFD
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.56
Date 2025-02-26
D.O.I. doi.org/10.1016/j.cell.2024.12.001
Net Summary
Imin 3.64
Number of Linked Nodes 277
Number of Links 304
Number of Hubs 37
Number of Links mediated by Hubs 140
Number of Communities 8
Number of Nodes involved in Communities 30
Number of Links involved in Communities 36
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 45971
Length Of Smallest Path 3
Average Path Length 13.7483
Length of Longest Path 36
Minimum Path Strength 1.41
Average Path Strength 6.71299
Maximum Path Strength 20.59
Minimum Path Correlation 0.7
Average Path Correlation 0.931803
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 53.2179
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.8277
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8BUD0
Sequence
>8ZFD_Chain_R
VDSRVDHLF PPSLYIFVI GVGLPTNCL ALWAAYRQV RQHNELGVY 
LMNLSIADL LYICTLPLW VDYFLHHDN WIHGPGSCK LFGFIFYSN 
IYISIAFLC CISVDRYLA VAHPLRFAR LRRVKTAVA VSSVVWATE 
LGANSAPLF HDELFRDRY NHTFCFEKF PMERWVAWM NLYRVFVGF 
LFPWALMLL CYRGILRAV QSSVSTERQ EKVKIKRLA LSLIAIVLV 
CFAPYHALL LSRSAVYLG RPWDCGFEE RVFSAYHSS LAFTSLNCV 
ADPILYCLV NEGARSDVA KALHNL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZFD.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.