Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I34 2.545459
2A:A:V49 3.824156
3A:A:K50 2.9425409
4A:A:S59 2.57409
5A:A:V216 3.24754154
6A:A:P217 3.378504
7A:A:F218 6.10754157
8A:A:Q226 3.9175439
9A:A:E229 6.695439
10A:A:W233 17.474539
11A:A:F234 7.7125439
12A:A:E235 5.925478
13A:A:F237 4.225639
14A:A:V247 3.9345137
15A:A:F272 8.3875409
16A:A:V280 6.5475475
17A:A:F281 4.7375479
18A:A:I287 4.058589
19A:A:F289 4.14589
20A:A:K292 6.3565129
21A:A:I305 6.296596
22A:A:Y308 6.22405
23A:A:F312 6.47333695
24A:A:P316 5.744592
25A:A:D321 4.955495
26A:A:F325 7.64596
27A:A:F330 5.4725138
28A:A:Y343 5.22857789
29A:A:H345 6.146589
30A:A:F346 8.68405
31A:A:F359 3.155409
32A:A:M375 4.65426
33B:B:L4 5.24754174
34B:B:L14 5.2125408
35B:B:T34 5.19754105
36B:B:I37 4.7354102
37B:B:H54 6.07667659
38B:B:M61 3.61456
39B:B:W63 4.49143757
40B:B:D76 3.895409
41B:B:I81 2.8775407
42B:B:W82 7.74714759
43B:B:Y85 11.2625454
44B:B:K89 5.415659
45B:B:I93 4.866507
46B:B:L95 3.17408
47B:B:W99 6.616539
48B:B:V100 3.422539
49B:B:S108 5.3354186
50B:B:N110 4.52254184
51B:B:Y111 3.216504
52B:B:A113 1.9975439
53B:B:C114 1.715408
54B:B:G115 1.888539
55B:B:L117 3.13667639
56B:B:Y124 4.168506
57B:B:H142 6.986539
58B:B:Y145 14.136538
59B:B:L146 3.0375437
60B:B:C149 2.404538
61B:B:F151 3.2875439
62B:B:I157 2.435407
63B:B:T159 4.146539
64B:B:S160 2.584546
65B:B:S161 4.39539
66B:B:D163 5.978539
67B:B:W169 8.092538
68B:B:F180 8.1875447
69B:B:H183 7.98833649
70B:B:G185 3.0425435
71B:B:D186 3.1575439
72B:B:V187 4.148549
73B:B:F199 4.668549
74B:B:V200 3.99546
75B:B:S201 2.5875449
76B:B:K209 11.485446
77B:B:W211 7.43571748
78B:B:C218 4.03445
79B:B:Q220 3.31547
80B:B:F222 6.262548
81B:B:H225 6.762549
82B:B:F235 6.25857766
83B:B:P236 8.17467
84B:B:N237 6.205465
85B:B:F241 6.08833646
86B:B:T243 4.0875408
87B:B:D247 6.295449
88B:B:R251 7.11548
89B:B:F253 6.816546
90B:B:L255 3.185446
91B:B:R256 12.05409
92B:B:Y264 5.14665
93B:B:I273 3.6825406
94B:B:V276 2.0225406
95B:B:F278 5.46567
96B:B:R283 7.5365109
97B:B:L285 2.63466
98B:B:Y289 5.916507
99B:B:L300 5.254106
100B:B:H311 8.045119
101B:B:C317 2.6125407
102B:B:T321 4.65557
103B:B:D323 7.2525457
104B:B:D333 7.154119
105B:B:L336 3.03457
106B:B:K337 5.88754116
107B:B:W339 7.6954119
108G:G:V16 3.5975407
109G:G:L19 5.63409
110G:G:E22 3.3325449
111G:G:M38 3.94754104
112G:G:Y40 6.075466
113G:G:H44 7.595406
114G:G:D48 5.2245219
115G:G:N59 5.0375459
116G:G:P60 5.565459
117G:G:F61 4.28714758
118R:R:V15 4.674224
119R:R:P21 5.84407
120R:R:L23 2.81415
121R:R:Y24 6.414519
122R:R:G31 2.214528
123R:R:T34 3.566527
124R:R:N35 6.642529
125R:R:R44 6.5475404
126R:R:Q45 6.6125425
127R:R:V46 1.9775426
128R:R:L52 6.7925428
129R:R:Y55 2.8075407
130R:R:L56 3.072528
131R:R:M57 2.544235
132R:R:L59 5.384529
133R:R:D63 5.484529
134R:R:Y66 6.91667617
135R:R:L70 6.8825418
136R:R:W73 7.7517
137R:R:Y76 6.6125416
138R:R:W83 6.80333619
139R:R:F97 9.49833617
140R:R:Y98 5.955415
141R:R:T99 7.33254245
142R:R:I101 4.41418
143R:R:I103 5.4854247
144R:R:L108 4.9428
145R:R:I111 5.568529
146R:R:D114 6.4025428
147R:R:R115 7.0725429
148R:R:Y116 3.945258
149R:R:P152 5.034263
150R:R:F169 4.9975404
151R:R:F172 8.9125415
152R:R:M174 4.185411
153R:R:F190 3.39408
154R:R:M197 3.485427
155R:R:Y201 5.328528
156R:R:I204 3.455426
157R:R:L205 4.0175425
158R:R:E218 4.214165
159R:R:I222 3.315427
160R:R:L229 6.285408
161R:R:F237 5.42667618
162R:R:Y240 6.64716
163R:R:H241 6.9975418
164R:R:L244 5.195415
165R:R:R247 8.82167614
166R:R:F260 4.8925401
167R:R:E261 5.542514
168R:R:F265 9.476514
169R:R:Y268 12.92415
170R:R:N278 7.15409
171R:R:D282 6.254529
172R:R:P283 5.01629
173R:R:Y286 5.305429
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:M61 22.01783.24YesYes076
2B:B:A60 B:B:C317 35.72821.81NoYes077
3B:B:A60 B:B:Y59 35.89684NoNo078
4B:B:V100 B:B:Y59 35.95378.83YesNo098
5B:B:G115 B:B:V100 38.39231.84YesYes399
6B:B:G115 B:B:L146 44.27631.71YesYes397
7B:B:L146 B:B:T159 44.47455.9YesYes379
8B:B:S161 B:B:T159 64.24721.6YesYes399
9B:B:G162 B:B:S161 68.80351.86NoYes399
10B:B:G162 B:B:Y145 66.2594.35NoYes398
11A:A:W233 B:B:Y145 51.237353.05YesYes398
12A:A:W233 B:B:L117 50.12336.83YesYes399
13B:B:L117 B:B:W99 98.86272.28YesYes399
14A:A:E208 B:B:W99 10010.9NoYes099
15A:A:E208 A:A:K219 99.92919.45NoNo096
16A:A:K219 A:A:K50 99.78642.87NoYes069
17A:A:K50 A:A:L48 98.75812.82YesNo096
18A:A:L48 A:A:P217 98.68271.64NoYes064
19B:B:C317 B:B:G330 16.75991.96YesNo075
20B:B:M101 B:B:Y145 49.93923.59NoYes398
21B:B:L117 B:B:M101 49.94922.83YesNo399
22A:A:P217 A:A:V216 98.14723.53YesYes044
23A:A:F218 A:A:V216 31.10993.93YesYes1574
24A:A:F218 A:A:I51 30.89112.51YesNo077
25A:A:I51 A:A:L244 30.65184.28NoNo078
26A:A:I287 A:A:L244 30.4135.71YesNo098
27A:A:F359 A:A:V216 66.46043.93YesYes094
28A:A:F330 A:A:L326 12.14762.44YesNo088
29A:A:L290 A:A:V247 12.69622.98NoYes1397
30A:A:F346 A:A:L290 22.25556.09YesNo059
31A:A:F346 A:A:T293 28.78242.59YesNo056
32A:A:T293 A:A:T348 28.98641.57NoNo068
33A:A:N351 A:A:T348 29.39381.46NoNo098
34A:A:E353 A:A:N351 31.21375.26NoNo059
35A:A:E353 A:A:R356 31.41463.49NoNo056
36A:A:R356 A:A:R360 31.61528.53NoNo064
37A:A:L357 A:A:R360 31.81569.72NoNo044
38A:A:H345 A:A:L357 32.015710.29YesNo094
39A:A:H345 A:A:I287 23.59742.65YesYes899
40B:B:G330 B:B:T329 10.26041.82NoNo058
41A:A:S242 A:A:S285 10.0183.26NoNo088
42A:A:F359 A:A:K363 63.97922.48YesNo097
43A:A:I366 A:A:V362 10.17543.07NoNo088
44A:A:K363 R:R:P122 63.84796.69NoNo077
45A:A:N370 R:R:P122 73.77073.26NoNo087
46A:A:N370 R:R:A118 73.63244.69NoNo088
47A:A:L374 R:R:A118 73.49391.58NoNo058
48A:A:L374 R:R:N50 73.1654.12NoNo257
49R:R:N50 R:R:Q45 73.076610.56NoYes275
50R:R:L52 R:R:Q45 11.87525.32YesYes285
51B:B:T321 B:B:W63 13.040710.92YesYes577
52B:B:G324 B:B:T321 11.08361.82NoYes597
53B:B:G324 B:B:K280 11.06973.49NoNo091
54B:B:K280 G:G:D48 10.92226.91NoYes019
55B:B:S281 G:G:D48 11.76464.42NoYes099
56B:B:D258 B:B:R22 10.515313.1NoNo076
57B:B:S147 B:B:Y145 37.69245.09NoYes098
58B:B:S147 B:B:S160 37.51291.63NoYes096
59B:B:S160 B:B:V187 31.38274.85YesYes469
60B:B:H183 B:B:V187 11.22574.15YesYes499
61B:B:S201 B:B:V187 19.83613.23YesYes499
62B:B:H183 B:B:K209 11.38620.96YesYes496
63B:B:G202 B:B:S201 19.49681.86NoYes069
64B:B:G202 B:B:I229 19.32581.76NoNo067
65B:B:G244 B:B:I273 12.23735.29NoYes056
66B:B:G244 B:B:T243 12.37973.64NoYes058
67B:B:I229 B:B:T243 19.17296.08NoYes078
68B:B:K209 B:B:T221 10.973312.01YesNo467
69B:B:T221 G:G:E22 11.13164.23NoYes479
70B:B:Q220 G:G:E22 11.12342.55YesYes479
71R:R:L56 R:R:Q45 59.23033.99YesYes285
72R:R:L56 R:R:Y286 52.12283.52YesYes289
73R:R:L108 R:R:Y286 51.67145.86YesYes289
74R:R:D282 R:R:L108 44.04148.14YesYes298
75R:R:D282 R:R:N278 38.64636.73YesYes099
76R:R:F237 R:R:N278 31.865910.87YesYes089
77R:R:F237 R:R:T275 18.47622.59YesNo188
78R:R:T275 R:R:Y240 18.4443.75NoYes186
79R:R:F107 R:R:W142 10.05815.01NoNo089
80B:B:M61 B:B:W63 16.76822.33YesYes567
81B:B:C149 B:B:T159 16.69361.69YesYes389
82A:A:I366 R:R:P122 10.06796.77NoNo087
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9JHP
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2-G13)/Beta1/Gamma2
PDB Resolution 3.35
Date 2025-04-23
D.O.I. doi.org/10.1038/s41422-025-01092-w
Net Summary
Imin 1.58
Number of Linked Nodes 859
Number of Links 1077
Number of Hubs 173
Number of Links mediated by Hubs 606
Number of Communities 26
Number of Nodes involved in Communities 256
Number of Links involved in Communities 372
Path Summary
Number Of Nodes in MetaPath 83
Number Of Links MetaPath 82
Number of Shortest Paths 1142966
Length Of Smallest Path 3
Average Path Length 31.2445
Length of Longest Path 63
Minimum Path Strength 1.215
Average Path Strength 5.37964
Maximum Path Strength 35.045
Minimum Path Correlation 0.71
Average Path Correlation 0.985628
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 6.45161
Average % Of Corr. Nodes 47.6002
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.8219
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • D5 dopamine receptor binding   • dopamine receptor binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cation binding   • metal ion binding   • multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • biological regulation   • regulation of biological quality   • blood circulation   • developmental process   • cellular developmental process   • cell differentiation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process
Gene OntologyBiological Process• multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • biological regulation   • regulation of biological quality   • blood circulation   • developmental process   • cellular developmental process   • cell differentiation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of cell motility   • regulation of fibroblast migration   • fibroblast migration   • regulation of locomotion   • ameboidal-type cell migration   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • multicellular organism development   • embryo development ending in birth or egg hatching   • chordate embryonic development   • anatomical structure development   • embryo development   • in utero embryonic development   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of developmental process   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • system development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • tissue development   • vasculature development   • circulatory system development   • branching involved in blood vessel morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • regulation of cellular component organization   • cellular component organization   • cellular component biogenesis   • cellular component assembly   • regulation of postsynapse assembly   • cell junction assembly   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of synapse assembly   • postsynapse organization   • postsynapse assembly   • regulation of postsynapse organization   • nervous system development   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • cell junction organization   • synapse assembly   • Rho-activating G protein-coupled receptor signaling pathway   • regulation of signaling   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • regulation of intracellular signal transduction   • regulation of response to stimulus   • intracellular signaling cassette   • regulation of cell communication   • Rho protein signal transduction   • cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • pigment granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • intracellular organelle   • melanosome   • cytoplasmic vesicle
Gene OntologyCellular Component• cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • pigment granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • intracellular organelle   • melanosome   • cytoplasmic vesicle   • organelle   • cytoplasm   • vesicle   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • cytosol   • brush border membrane   • cluster of actin-based cell projections   • plasma membrane bounded cell projection   • brush border   • cell projection   • apical part of cell   • plasma membrane region   • apical plasma membrane   • cell projection membrane   • postsynapse   • synapse   • nucleus   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • nephron development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • epithelium development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>9JHP_Chain_A
SKEIDKCLS REKTYVKRL VKILLLGAS GKSTFLKQM RIIGIHEYD 
FEIKNVPFK MVDVGGQRS ERKRWFECF DSVTSILFL VSSFRLTES 
LNFETIVNN RVFSNVSII LFLNKTDLL EEKVQIVSI KDYFLEFEG 
DPHCLRDVQ KFLVECFRN KRRDQQQKP LYHHFTTAI NTENRLFRD 
VKDTILHDN LKQLMLQVS AEDKAAAER DNDDNDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JHP_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JHP_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JHP_Chain_R
GCHVDSRVD HLFPPSLYI VIGVGLPTN CLALWAAYR QVQQRNELG 
YLMLSIADL YICTLPWVD YFHHDNWIH GPGSCKLFF IFYTNIYIS 
IAFLCCIVD RYLAVAHPL RFRLRRVTV AVSSVVWAT ELGANSAPL 
FHDELFRDR YNHTCFEKF PMEGWVAWM NLYRFVGFF PWAMLSYRL 
RVRGSVSTE RQEKAKIKL ALSLAIVLV CFAPYHVLL SRSAIYGRP 
WDCGFEERV FSAYHSSAF TSLNCVDPI YLVNEGARS DFVNLLLGS 
AKAFVLLLG IARILLLAL C


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JHP.zip



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