Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L30 2.835475
2A:A:H41 3.858526
3A:A:L43 4.1125427
4A:A:L45 5.28428
5A:A:L46 2.89418
6A:A:N50 7.006529
7A:A:I207 4.8419
8A:A:F212 7.566529
9A:A:V214 4.3725426
10A:A:V217 3.804525
11A:A:F219 5.91667628
12A:A:H220 8.905417
13A:A:M221 5.506528
14A:A:F222 7.864517
15A:A:Q227 4.148519
16A:A:E230 9.2625419
17A:A:R231 6.4325409
18A:A:R232 8.5775418
19A:A:K233 8.252519
20A:A:W234 7.648519
21A:A:C237 3.7925418
22A:A:F238 7.10333619
23A:A:I244 3.458518
24A:A:I245 4.46627
25A:A:V247 5.11427
26A:A:D249 11.9375428
27A:A:Y253 6.4925408
28A:A:L270 5.885406
29A:A:F273 4.08875889
30A:A:I276 3.734518
31A:A:W277 6.07143786
32A:A:W281 7.01515
33A:A:L282 5.97419
34A:A:I288 4.788529
35A:A:L289 3.58589
36A:A:F290 5.8925829
37A:A:L291 4.8025408
38A:A:N292 5.816529
39A:A:K293 6.6875429
40A:A:Q294 7.3475486
41A:A:I308 7.84147
42A:A:F312 4.3175408
43A:A:F315 8.8054146
44A:A:P321 4.8625405
45A:A:D331 8.37404
46A:A:V334 3.035404
47A:A:Y339 5.83167683
48A:A:F340 7.2585147
49A:A:R342 7.012584
50A:A:E344 6.5525405
51A:A:F345 5.534588
52A:A:S349 4.144587
53A:A:C359 3.692585
54A:A:Y360 9.28628
55A:A:F363 9.188585
56A:A:T364 7.0525429
57A:A:R374 5.7975424
58A:A:I375 3.44429
59A:A:F376 4.47167628
60A:A:D378 10.0475427
61A:A:D381 4.9525428
62A:A:I382 6.275426
63A:A:I383 4.016528
64A:A:R385 7.09525
65A:A:H387 5.775428
66A:A:L388 4.296528
67A:A:Y391 7.822504
68A:A:E392 6.5475436
69A:A:L394 6.105428
70B:B:V40 4.6056103
71B:B:L51 8.105409
72B:B:H54 8.425679
73B:B:K57 10.67519
74B:B:Y59 10.854518
75B:B:M61 4.7625406
76B:B:W63 6.76507
77B:B:L70 6.31405
78B:B:V71 4.34408
79B:B:Q75 9.9275419
80B:B:D76 5.68579
81B:B:K78 3.8525478
82B:B:L79 5.0825497
83B:B:I80 8.865478
84B:B:I81 4.594597
85B:B:W82 9.65333679
86B:B:N88 6.5725477
87B:B:K89 6.21679
88B:B:H91 5.62495
89B:B:I93 4.8497
90B:B:L95 5.9498
91B:B:W99 8.22286719
92B:B:Y105 4.956506
93B:B:N110 4.375414
94B:B:Y111 5.03167614
95B:B:V112 4.56408
96B:B:C114 4.585498
97B:B:L117 4.5075419
98B:B:I123 4.134516
99B:B:Y124 5.52571796
100B:B:E130 3.3875403
101B:B:V133 4.5625494
102B:B:L139 7.64409
103B:B:H142 7.73429719
104B:B:Y145 6.09718
105B:B:C148 4.2875456
106B:B:F151 4.175819
107B:B:L152 5.2925453
108B:B:I157 5417
109B:B:V158 4.99455
110B:B:T159 6.7625419
111B:B:S160 5.9225456
112B:B:S161 8.465419
113B:B:D163 7.686519
114B:B:T165 4.385417
115B:B:L168 3.9925456
116B:B:W169 9.02667618
117B:B:D170 6.99459
118B:B:I171 4.1475416
119B:B:Q176 7.335414
120B:B:F180 8.38557
121B:B:H183 8.96833659
122B:B:D186 8.9575419
123B:B:V187 4.725459
124B:B:L190 6.525455
125B:B:F199 7.12659
126B:B:V200 6.6425466
127B:B:C204 4.38333617
128B:B:D205 7.34459
129B:B:K209 10.776556
130B:B:W211 9.582558
131B:B:D212 8.1654169
132B:B:C218 5.532555
133B:B:Q220 5.3925467
134B:B:F222 6.96833668
135B:B:H225 8.5769
136B:B:D228 7.894519
137B:B:I232 5.4825468
138B:B:F234 5.375405
139B:B:F235 6.4716
140B:B:F241 6.67167666
141B:B:T243 4.808568
142B:B:D247 6.936569
143B:B:T249 5.102566
144B:B:R251 12.984568
145B:B:F253 7.31566
146B:B:D254 3.75333609
147B:B:R256 6.9775409
148B:B:D258 10.0325467
149B:B:T263 6.6125461
150B:B:Y264 4.92833615
151B:B:I273 5.955406
152B:B:T274 5.3425418
153B:B:V276 3.6406
154B:B:F278 6.525617
155B:B:R283 9.17254109
156B:B:L285 5.5125416
157B:B:Y289 5.32429717
158B:B:D290 6.042516
159B:B:N293 5.0525415
160B:B:N295 6.608516
161B:B:V296 3.8125405
162B:B:W297 6.37167618
163B:B:L300 5.28754106
164B:B:K301 5.97405
165B:B:L308 7.5175407
166B:B:H311 8.625119
167B:B:R314 12.654518
168B:B:L318 3.2925116
169B:B:V327 3.5854116
170B:B:T329 4.8525408
171B:B:W332 12.8529719
172B:B:D333 12.21754119
173B:B:L336 4.2725407
174B:B:K337 7.61754116
175B:B:I338 4.5454125
176B:B:W339 6.132867119
177G:G:Q18 4.1075459
178G:G:R27 7.285408
179G:G:M38 2.6585104
180G:G:Y40 6.995416
181G:G:D48 8.0125109
182G:G:L51 5.868336106
183G:G:F61 4.813758128
184R:R:V11 8.02443
185R:R:D16 8.055405
186R:R:P20 5.836545
187R:R:Y24 6.636509
188R:R:N35 8.0575439
189R:R:W40 6.0275404
190R:R:E51 8.7075437
191R:R:L52 3.4325438
192R:R:Y55 5.71571737
193R:R:L56 3.946538
194R:R:M57 3.438505
195R:R:L59 5.5275439
196R:R:D63 6.12539
197R:R:Y66 6.94167607
198R:R:L70 6.4725408
199R:R:W73 8.432547
200R:R:Y76 8.02546
201R:R:F77 7.3175445
202R:R:W83 5.5475849
203R:R:H85 6.815447
204R:R:F97 7.674507
205R:R:T99 6.2275435
206R:R:I101 5.6775438
207R:R:Y102 6.82637
208R:R:I103 5.98637
209R:R:F107 7.024538
210R:R:L108 5.56438
211R:R:I111 4.354539
212R:R:P122 4.5925427
213R:R:L123 4.23333626
214R:R:R130 7.0154136
215R:R:W142 7.1675439
216R:R:E145 9.795437
217R:R:F167 7.8025441
218R:R:F172 10.396545
219R:R:P173 5.825444
220R:R:W177 10.9175431
221R:R:M181 5.1725434
222R:R:F190 5.505408
223R:R:Y201 5.86571738
224R:R:S211 4.2425425
225R:R:S213 4.66523
226R:R:T214 6.555423
227R:R:E218 7.9175425
228R:R:L229 5.2475408
229R:R:I230 4.16407
230R:R:F237 7.18333638
231R:R:Y240 8.008536
232R:R:H241 8.4925438
233R:R:C258 5.29448
234R:R:F260 8.6225441
235R:R:V264 9.2075444
236R:R:F265 7.84333644
237R:R:H269 8.674545
238R:R:D282 8.4275439
239R:R:L285 3.57405
240R:R:Y286 6.2439
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H62 B:B:Y105 10.393.27NoYes066
2B:B:H62 B:B:R150 10.724816.93NoNo066
3B:B:C148 B:B:R150 12.71885.57YesNo066
4B:B:C148 B:B:T102 27.41413.38YesNo068
5B:B:C149 B:B:T102 27.74748.45NoNo088
6B:B:C121 B:B:C149 18.64413.64NoNo088
7B:B:C121 B:B:T159 18.86183.38NoYes089
8B:B:H142 B:B:S161 25.699415.34YesYes199
9B:B:G162 B:B:S161 35.88673.71NoYes199
10B:B:G162 B:B:Y145 35.97138.69NoYes198
11B:B:I157 B:B:W169 11.98983.52YesYes178
12B:B:H142 B:B:W169 15.56423.17YesYes198
13A:A:W234 B:B:Y145 50.9564.82YesYes198
14A:A:F238 A:A:W234 26.4866.01YesYes199
15R:R:E51 R:R:Y55 27.921111.22YesYes377
16R:R:E51 R:R:R129 29.54343.49YesNo077
17A:A:H387 R:R:R129 65.05589.03YesNo087
18A:A:H387 A:A:I383 1006.63YesYes288
19A:A:H41 A:A:I383 97.34412.65YesYes268
20A:A:F219 A:A:H41 97.25184.53YesYes286
21A:A:F219 A:A:L43 97.16053.65YesYes287
22A:A:L43 A:A:M221 47.59644.24YesYes278
23A:A:L45 A:A:M221 47.588811.31YesYes288
24A:A:K53 A:A:L45 96.29242.82NoYes098
25A:A:G47 A:A:K53 96.2673.49NoNo099
26A:A:G47 A:A:L46 98.21221.71NoYes098
27A:A:L44 A:A:L46 34.46014.15NoYes198
28A:A:F238 A:A:L44 34.630617.05YesNo199
29A:A:I245 A:A:L43 48.53275.71YesYes277
30A:A:I245 A:A:L45 48.85924.28YesYes278
31A:A:I276 A:A:L46 48.05492.85YesYes188
32A:A:I276 A:A:R231 26.24077.52YesYes089
33A:A:R231 A:A:W234 26.104912YesYes099
34A:A:K233 B:B:Y145 17.65524.78YesYes198
35A:A:K233 B:B:D228 17.223411.06YesYes199
36A:A:N279 A:A:W281 32.22423.39NoYes185
37A:A:W281 B:B:D290 23.86735.58YesYes156
38A:A:I244 A:A:L282 15.94764.28YesYes189
39A:A:L282 A:A:N279 32.3189.61YesNo198
40A:A:H387 R:R:A118 35.52034.39YesNo088
41A:A:Y391 R:R:A118 35.48289.34YesNo048
42A:A:Y391 R:R:R129 35.48135.14YesNo047
43A:A:Y391 R:R:R115 68.77684.12YesNo049
44R:R:I111 R:R:R115 34.11673.76YesNo099
45R:R:I111 R:R:Y55 17.12644.84YesYes397
46B:B:C271 B:B:D290 17.20596.22NoYes156
47B:B:C271 B:B:Y289 16.63374.03NoYes157
48B:B:D258 B:B:F222 13.78384.78YesYes678
49B:B:D258 B:B:R22 11.280716.68YesNo076
50B:B:F222 B:B:F253 10.881910.72YesYes686
51B:B:D228 B:B:S227 16.93957.36YesNo096
52B:B:D247 B:B:S227 16.83562.94YesNo096
53R:R:S138 R:R:Y55 10.54582.54NoYes377
54R:R:F107 R:R:S138 10.35212.64YesNo387
55R:R:F107 R:R:I103 10.07042.51YesYes387
56R:R:I111 R:R:Y286 48.34736.04YesYes399
57R:R:L108 R:R:Y286 48.32327.03YesYes389
58R:R:L108 R:R:L59 39.6245.54YesYes389
59R:R:D63 R:R:L59 39.14624.07YesYes399
60R:R:C279 R:R:D63 74.08124.67NoYes099
61R:R:C279 R:R:Y66 58.70324.03NoYes097
62R:R:L70 R:R:Y66 15.899.38YesYes087
63R:R:L70 R:R:Y24 26.27419.38YesYes089
64R:R:F77 R:R:Y24 49.68397.22YesYes059
65R:R:F77 R:R:H269 12.45919.05YesYes455
66R:R:R115 R:R:Y201 34.59666.17NoYes098
67R:R:M197 R:R:Y201 32.22573.59NoYes378
68R:R:L108 R:R:M197 32.14554.24YesNo387
69R:R:D282 R:R:L108 40.60845.43YesYes398
70R:R:D282 R:R:D63 39.16355.32YesYes399
71R:R:C279 R:R:I67 14.90453.27NoNo096
72R:R:I67 R:R:L70 14.42512.85NoYes068
73R:R:F97 R:R:Y66 31.801310.32YesYes077
74R:R:F97 R:R:Y24 13.78395.16YesYes079
75R:R:S276 R:R:Y66 14.82853.82NoYes077
76R:R:S276 R:R:Y24 13.77057.63NoYes079
77R:R:F97 R:R:W73 15.926511.02YesYes077
78R:R:F77 R:R:P20 33.119210.11YesYes455
79R:R:F19 R:R:P20 10.36091.44NoYes055
80R:R:A273 R:R:P20 14.50513.74NoYes055
81R:R:A273 R:R:L23 12.4333.15NoNo055
82R:R:L23 R:R:L277 10.36094.15NoNo055
83A:A:I276 A:A:L282 16.57492.85YesYes189
84B:B:D247 B:B:H225 13.04237.56YesYes699
85A:A:I244 A:A:L46 16.082.85YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z65
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.98
Date 2025-04-23
D.O.I. To be published
Net Summary
Imin 2.5
Number of Linked Nodes 866
Number of Links 1161
Number of Hubs 240
Number of Links mediated by Hubs 820
Number of Communities 16
Number of Nodes involved in Communities 323
Number of Links involved in Communities 521
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 10425474
Length Of Smallest Path 3
Average Path Length 33.0651
Length of Longest Path 54
Minimum Path Strength 1.33
Average Path Strength 5.44037
Maximum Path Strength 26.94
Minimum Path Correlation 0.7
Average Path Correlation 0.995873
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 32.793
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 65.8996
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • Ras protein signal transduction   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8Z65_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIHVVTS 
GIFETKFQV DKVNFHMFD VGQRDERRK WIQCFNDVT AIIFVVSSY 
NRLQEALNF KSIWNNRWL RTISVILFL NKQDLLAEK VLAGKSKIE 
DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF LRISTASGD 
GRHYCYPHF TCVDTENRR FNDCRDIIQ RMHLRQYEL LTLSADAVR 
SMDNYKADD DSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8Z65_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8Z65_Chain_G
RKLVEQLKM EANIDRIKV SKAAADLMA YCEAHAKED PLLTPVPAS 
ENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>8Z65_Chain_R
GCHVDSRVD HLFPPSLYI VIGVGLPTN CLALWAAYR QVQQRNELG 
YLMLSIADL YICTLPWVD YFHHDNWIH GPGSCKLFF IFYTNIYIS 
IAFLCCIVD RYLAVAHPL RFRLRRVTV AVSSVVWAT ELGANSAPL 
FHDELFRDR YNHTCFEKF PMGWVAWMN LYRFVGFFP WAMLSYRLR 
VRGSVSTER QEKAKIKLA LSLAIVLVC FAPYHVLLS RSAIYRPWD 
CGFEERVFS AYHSSAFTS LNCVDPIYL VNEGARSDA KALHNLFVN 
LLLGSAKAF VLLLGIARI LLLALCV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z65.zip



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