psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G8	R:R:P173	4.06	No	Yes	0	5	4
2	R:R:C258	R:R:C9	3.64	Yes	No	0	8	8
3	R:R:F172	R:R:V11	10.49	Yes	Yes	1	5	3
4	R:R:E261	R:R:V11	5.7	No	Yes	0	4	3
5	R:R:V11	R:R:V264	8.02	Yes	Yes	1	3	4
6	R:R:F265	R:R:V11	7.87	Yes	Yes	1	4	3
7	R:R:D12	R:R:R14	7.15	No	No	0	6	2
8	R:R:D16	R:R:S13	8.83	Yes	No	0	5	5
9	R:R:F265	R:R:S13	11.89	Yes	No	0	4	5
10	R:R:D16	R:R:P20	8.05	Yes	Yes	0	5	5
11	R:R:D16	R:R:H269	13.87	Yes	Yes	0	5	5
12	R:R:H17	R:R:L18	16.71	No	No	0	5	4
13	R:R:H17	R:R:H80	7.17	No	No	0	5	4
14	R:R:P20	R:R:P21	5.84	Yes	No	0	5	7
15	R:R:F77	R:R:P20	10.11	No	Yes	0	5	5
16	R:R:A273	R:R:P20	3.74	No	Yes	0	5	5
17	R:R:L23	R:R:L277	4.15	No	No	0	5	5
18	R:R:L70	R:R:Y24	9.38	No	Yes	0	8	9
19	R:R:V74	R:R:Y24	3.79	No	Yes	0	7	9
20	R:R:F77	R:R:Y24	7.22	No	Yes	0	5	9
21	R:R:F97	R:R:Y24	5.16	Yes	Yes	0	7	9
22	R:R:S276	R:R:Y24	7.63	No	Yes	0	7	9
23	R:R:F26	R:R:V30	7.87	No	No	0	4	6
24	R:R:G29	R:R:I28	3.53	No	No	0	5	7
25	R:R:I28	R:R:L70	4.28	No	No	0	7	8
26	R:R:I28	R:R:P71	3.39	No	No	0	7	8
27	R:R:G31	R:R:T34	3.64	No	No	0	8	7
28	R:R:G31	R:R:V280	3.68	No	No	0	8	8
29	R:R:L32	R:R:P33	4.93	No	No	0	6	5
30	R:R:P283	R:R:T34	6.99	No	No	0	9	7
31	R:R:N35	R:R:S60	5.96	No	No	0	9	8
32	R:R:D63	R:R:N35	12.12	Yes	No	0	9	9
33	R:R:N35	R:R:P283	11.4	No	No	0	9	9
34	R:R:L37	R:R:V297	4.47	No	No	0	7	7
35	R:R:L39	R:R:S60	4.5	No	No	0	7	8
36	R:R:W40	R:R:Y43	4.82	Yes	No	0	4	4
37	R:R:R44	R:R:W40	10	No	Yes	0	4	4
38	R:R:D296	R:R:W40	6.7	No	Yes	0	4	4
39	R:R:A41	R:R:D296	4.63	No	No	0	7	4
40	R:R:M57	R:R:Y43	3.59	Yes	No	0	5	4
41	R:R:N50	R:R:Q45	10.56	No	No	0	7	5
42	R:R:V46	R:R:V54	6.41	No	No	0	6	5
43	R:R:M57	R:R:V46	6.09	Yes	No	0	5	6
44	R:R:E51	R:R:Y55	11.22	Yes	Yes	2	7	7
45	R:R:D114	R:R:E51	15.59	No	Yes	2	8	7
46	R:R:E51	R:R:R129	3.49	Yes	No	0	7	7
47	R:R:A134	R:R:E51	4.53	No	Yes	2	5	7
48	R:R:L52	R:R:L56	4.15	No	Yes	0	8	8
49	R:R:G53	R:R:L56	5.13	No	Yes	0	7	8
50	R:R:A134	R:R:V54	3.39	No	No	0	5	5
51	R:R:C110	R:R:Y55	5.38	No	Yes	0	7	7
52	R:R:I111	R:R:Y55	4.84	Yes	Yes	2	9	7
53	R:R:D114	R:R:Y55	6.9	No	Yes	2	8	7
54	R:R:A134	R:R:Y55	5.34	No	Yes	2	5	7
55	R:R:V137	R:R:Y55	3.79	No	Yes	0	5	7
56	R:R:I111	R:R:L56	4.28	Yes	Yes	2	9	8
57	R:R:L56	R:R:Y286	3.52	Yes	Yes	2	8	9
58	R:R:F107	R:R:N58	15.71	No	No	3	8	7
59	R:R:N58	R:R:S138	5.96	No	No	0	7	7
60	R:R:N58	R:R:W142	4.52	No	Yes	3	7	9
61	R:R:D63	R:R:L59	4.07	Yes	No	2	9	9
62	R:R:L108	R:R:L59	5.54	Yes	No	2	8	9
63	R:R:D282	R:R:L59	9.5	Yes	No	2	9	9
64	R:R:D63	R:R:S104	4.42	Yes	No	0	9	9
65	R:R:C279	R:R:D63	4.67	No	Yes	0	9	9
66	R:R:D282	R:R:D63	5.32	Yes	Yes	2	9	9
67	R:R:L70	R:R:Y66	9.38	No	Yes	0	8	7
68	R:R:F97	R:R:Y66	10.32	Yes	Yes	0	7	7
69	R:R:N100	R:R:Y66	10.47	No	Yes	0	8	7
70	R:R:I101	R:R:Y66	3.63	No	Yes	0	8	7
71	R:R:S276	R:R:Y66	3.82	No	Yes	0	7	7
72	R:R:C279	R:R:Y66	4.03	No	Yes	0	9	7
73	R:R:F93	R:R:T69	3.89	No	No	0	6	7
74	R:R:I96	R:R:T69	7.6	No	No	0	5	7
75	R:R:L72	R:R:W83	3.42	No	Yes	1	7	9
76	R:R:H85	R:R:L72	3.86	Yes	No	1	7	7
77	R:R:F93	R:R:L72	8.53	No	No	0	6	7
78	R:R:W73	R:R:Y76	11.58	Yes	Yes	1	7	6
79	R:R:W73	R:R:W83	7.5	Yes	Yes	1	7	9
80	R:R:G94	R:R:W73	4.22	No	Yes	0	8	7
81	R:R:F97	R:R:W73	11.02	Yes	Yes	0	7	7
82	R:R:C168	R:R:W73	7.84	No	Yes	1	9	7
83	R:R:D75	R:R:H79	5.04	No	No	0	4	4
84	R:R:D75	R:R:H85	13.87	No	Yes	0	4	7
85	R:R:D81	R:R:Y76	10.34	No	Yes	1	4	6
86	R:R:W83	R:R:Y76	9.65	Yes	Yes	1	9	6
87	R:R:F167	R:R:Y76	5.16	Yes	Yes	1	1	6
88	R:R:F77	R:R:H269	9.05	No	Yes	0	5	5
89	R:R:H79	R:R:L78	7.71	No	No	0	4	7
90	R:R:D81	R:R:F265	9.55	No	Yes	1	4	4
91	R:R:D81	R:R:H269	5.04	No	Yes	1	4	5
92	R:R:N82	R:R:T166	8.77	No	No	0	5	3
93	R:R:H85	R:R:W83	4.23	Yes	Yes	1	7	9
94	R:R:S89	R:R:W83	3.71	No	Yes	0	6	9
95	R:R:C90	R:R:W83	3.92	No	Yes	1	9	9
96	R:R:C168	R:R:W83	9.14	No	Yes	1	9	9
97	R:R:H85	R:R:I84	5.3	Yes	No	0	7	3
98	R:R:G86	R:R:P87	4.06	No	No	0	8	3
99	R:R:E157	R:R:P87	4.72	No	No	0	5	3
100	R:R:G88	R:R:K91	5.23	No	No	0	2	6
101	R:R:C90	R:R:L158	4.76	No	No	0	9	5
102	R:R:C168	R:R:C90	7.28	No	No	1	9	9
103	R:R:E157	R:R:K91	4.05	No	No	0	5	6
104	R:R:F93	R:R:L92	3.65	No	No	0	6	5
105	R:R:F95	R:R:T99	10.38	No	No	0	6	5
106	R:R:F95	R:R:L153	6.09	No	No	0	6	4
107	R:R:I96	R:R:N100	7.08	No	No	0	5	8
108	R:R:F97	R:R:Y98	9.28	Yes	No	0	7	5
109	R:R:F169	R:R:Y98	20.63	No	No	0	4	5
110	R:R:E145	R:R:T99	5.64	Yes	No	4	7	5
111	R:R:N149	R:R:T99	5.85	No	No	4	7	5
112	R:R:I101	R:R:Y102	7.25	No	Yes	0	8	7
113	R:R:F237	R:R:I101	8.79	Yes	No	0	8	8
114	R:R:E145	R:R:Y102	6.73	Yes	Yes	0	7	7
115	R:R:R185	R:R:Y102	12.35	No	Yes	0	5	7
116	R:R:H241	R:R:Y102	8.71	Yes	Yes	0	8	7
117	R:R:I103	R:R:W142	10.57	No	Yes	0	7	9
118	R:R:E145	R:R:I103	13.66	Yes	No	0	7	7
119	R:R:I105	R:R:P193	3.39	No	No	0	8	9
120	R:R:F237	R:R:I105	12.56	Yes	No	0	8	8
121	R:R:F107	R:R:V141	5.24	No	No	0	8	7
122	R:R:F107	R:R:W142	9.02	No	Yes	3	8	9
123	R:R:L108	R:R:M197	4.24	Yes	No	0	8	7
124	R:R:D282	R:R:L108	5.43	Yes	Yes	2	9	8
125	R:R:L108	R:R:Y286	7.03	Yes	Yes	2	8	9
126	R:R:I111	R:R:R115	3.76	Yes	No	0	9	9
127	R:R:I111	R:R:Y286	6.04	Yes	Yes	2	9	9
128	R:R:S112	R:R:S200	6.52	No	No	5	9	8
129	R:R:S112	R:R:Y201	13.99	No	Yes	5	9	8
130	R:R:R115	R:R:Y201	6.17	No	Yes	0	9	8
131	R:R:A120	R:R:Y116	8.01	No	Yes	0	7	8
132	R:R:H121	R:R:Y116	7.62	No	Yes	0	6	8
133	R:R:F125	R:R:L117	3.65	No	No	0	6	6
134	R:R:I204	R:R:V119	4.61	No	No	0	6	8
135	R:R:F125	R:R:H121	4.53	No	No	0	6	6
136	R:R:R127	R:R:R130	5.33	No	No	0	4	6
137	R:R:K132	R:R:R130	4.95	No	No	0	4	6
138	R:R:L146	R:R:W142	4.56	No	Yes	0	3	9
139	R:R:E145	R:R:N149	13.15	Yes	No	4	7	7
140	R:R:G147	R:R:S150	3.71	No	No	0	4	4
141	R:R:A148	R:R:Y184	4	No	No	0	5	3
142	R:R:M181	R:R:N149	4.21	No	No	0	4	7
143	R:R:A151	R:R:W177	3.89	No	Yes	0	7	1
144	R:R:F169	R:R:P152	13	No	No	0	4	3
145	R:R:P152	R:R:W177	5.4	No	Yes	0	3	1
146	R:R:H155	R:R:W177	28.56	No	Yes	0	4	1
147	R:R:F159	R:R:R160	5.34	No	No	0	2	1
148	R:R:F159	R:R:K171	9.93	No	No	0	2	3
149	R:R:H165	R:R:Y163	4.36	No	No	0	1	3
150	R:R:F167	R:R:H165	6.79	Yes	No	1	1	1
151	R:R:F265	R:R:H165	4.53	Yes	No	1	4	1
152	R:R:E170	R:R:F167	12.83	No	Yes	0	4	1
153	R:R:F167	R:R:F265	6.43	Yes	Yes	1	1	4
154	R:R:E170	R:R:H269	8.62	No	Yes	0	4	5
155	R:R:F172	R:R:P173	5.78	Yes	Yes	1	5	4
156	R:R:F172	R:R:R247	17.1	Yes	No	1	5	4
157	R:R:C258	R:R:F172	4.19	Yes	Yes	1	8	5
158	R:R:F172	R:R:V264	14.42	Yes	Yes	1	5	4
159	R:R:P173	R:R:W256	4.05	Yes	No	1	4	3
160	R:R:C258	R:R:P173	9.41	Yes	Yes	1	8	4
161	R:R:G176	R:R:M174	3.49	No	No	0	4	1
162	R:R:M174	R:R:Y251	17.96	No	No	0	1	3
163	R:R:M181	R:R:W177	5.82	No	Yes	0	4	1
164	R:R:N182	R:R:V178	4.43	No	No	0	5	2
165	R:R:A179	R:R:L252	4.73	No	No	0	1	6
166	R:R:L252	R:R:W180	3.42	No	No	0	6	3
167	R:R:M181	R:R:R185	7.44	No	No	0	4	5
168	R:R:L244	R:R:N182	10.98	No	No	0	5	5
169	R:R:N182	R:R:S248	7.45	No	No	0	5	5
170	R:R:V188	R:R:Y184	10.09	No	No	0	4	3
171	R:R:F187	R:R:V186	5.24	No	No	0	5	4
172	R:R:H241	R:R:V186	4.15	Yes	No	0	8	4
173	R:R:G189	R:R:P193	4.06	No	No	0	6	9
174	R:R:F190	R:R:L191	3.65	No	No	0	8	4
175	R:R:F190	R:R:F237	4.29	No	Yes	0	8	8
176	R:R:F190	R:R:H241	11.31	No	Yes	0	8	8
177	R:R:F192	R:R:L196	7.31	No	No	0	5	4
178	R:R:I230	R:R:W194	5.87	Yes	No	0	7	6
179	R:R:L234	R:R:W194	13.67	No	No	0	6	6
180	R:R:M197	R:R:Y201	3.59	No	Yes	0	7	8
181	R:R:I230	R:R:L198	5.71	Yes	No	0	7	5
182	R:R:S200	R:R:Y201	3.82	No	Yes	5	8	8
183	R:R:A226	R:R:Y201	4	No	Yes	0	7	8
184	R:R:L229	R:R:Y201	5.86	No	Yes	0	8	8
185	R:R:I230	R:R:Y201	3.63	Yes	Yes	0	7	8
186	R:R:R202	R:R:R206	9.6	No	No	0	3	3
187	R:R:K219	R:R:V208	4.55	No	No	0	6	8
188	R:R:S211	R:R:T214	6.4	No	No	0	5	3
189	R:R:E218	R:R:T214	5.64	No	No	0	5	3
190	R:R:K219	R:R:T214	9.01	No	No	0	6	3
191	R:R:E215	R:R:E218	7.61	No	No	0	3	5
192	R:R:Q217	R:R:R216	10.51	No	No	0	4	4
193	R:R:K221	R:R:R224	3.71	No	No	0	7	3
194	R:R:L225	R:R:S228	4.5	No	No	0	8	6
195	R:R:L229	R:R:L285	4.15	No	Yes	0	8	5
196	R:R:L229	R:R:Y286	8.21	No	Yes	0	8	9
197	R:R:I232	R:R:L285	4.28	No	Yes	0	7	5
198	R:R:F237	R:R:N278	12.08	Yes	No	0	8	9
199	R:R:P239	R:R:S271	5.34	No	No	0	9	7
200	R:R:H241	R:R:Y240	9.8	Yes	Yes	0	8	6
201	R:R:L244	R:R:Y240	7.03	No	Yes	0	5	6
202	R:R:L272	R:R:Y240	15.24	No	Yes	0	5	6
203	R:R:T275	R:R:Y240	4.99	No	Yes	0	8	6
204	R:R:A267	R:R:L243	6.3	No	No	0	5	6
205	R:R:L243	R:R:Y268	12.89	No	No	0	6	5
206	R:R:L244	R:R:Y268	5.86	No	No	0	5	5
207	R:R:R263	R:R:S246	3.95	No	No	0	3	4
208	R:R:R247	R:R:V264	13.08	No	Yes	1	4	4
209	R:R:R247	R:R:Y268	12.35	No	No	0	4	5
210	R:R:F260	R:R:I250	8.79	Yes	No	0	1	1
211	R:R:P255	R:R:R254	5.76	No	No	0	2	2
212	R:R:C258	R:R:W256	3.92	Yes	No	1	8	3
213	R:R:F260	R:R:R263	21.38	Yes	No	0	1	3
214	R:R:F265	R:R:H269	6.79	Yes	Yes	1	4	5
215	R:R:F274	R:R:L277	3.65	No	No	0	7	5
216	R:R:D282	R:R:N278	13.46	Yes	No	0	9	9
217	R:R:A293	R:R:C287	3.61	No	No	0	8	8
218	R:R:E291	R:R:R294	10.47	No	No	0	5	8
219	R:R:D296	R:R:V297	5.84	No	No	0	4	7
220	R:R:K299	R:R:N303	5.6	No	No	0	5	3
221	R:R:L158	R:R:P87	3.28	No	No	0	5	3
222	R:R:L123	R:R:P122	3.28	No	No	0	6	7
223	R:R:C279	R:R:I67	3.27	No	No	0	9	6
224	R:R:S211	R:R:S213	3.26	No	No	0	5	3
225	R:R:A62	R:R:I103	3.25	No	No	0	8	7
226	R:R:A281	R:R:I232	3.25	No	No	0	5	7
227	R:R:S276	R:R:V27	3.23	No	No	0	7	7
228	R:R:A42	R:R:M57	3.22	No	Yes	0	7	5
229	R:R:D257	R:R:P255	3.22	No	No	0	5	2
230	R:R:V280	R:R:V30	3.21	No	No	0	8	6
231	R:R:F125	R:R:R124	3.21	No	No	0	6	4
232	R:R:C109	R:R:L196	3.17	No	No	0	8	4
233	R:R:A273	R:R:L23	3.15	No	No	0	5	5
234	R:R:A238	R:R:L234	3.15	No	No	0	5	6
235	R:R:C236	R:R:N278	3.15	No	No	0	8	9
236	R:R:A293	R:R:N290	3.13	No	No	0	8	8
237	R:R:I222	R:R:V208	3.07	No	No	0	7	8
238	R:R:F260	R:R:G259	3.01	Yes	No	0	1	2
239	R:R:L64	R:R:S60	3	No	No	0	8	8
240	R:R:L285	R:R:S228	3	Yes	No	0	5	6
241	R:R:L245	R:R:V186	2.98	No	No	0	6	4
242	R:R:G203	R:R:Y116	2.9	No	Yes	0	3	8
243	R:R:F192	R:R:P193	2.89	No	No	0	5	9
244	R:R:F274	R:R:P239	2.89	No	No	0	7	9
245	R:R:I61	R:R:L65	2.85	No	No	0	5	7
246	R:R:I284	R:R:L285	2.85	No	Yes	0	7	5
247	R:R:I284	R:R:L288	2.85	No	No	0	7	7
248	R:R:K223	R:R:L227	2.82	No	No	0	6	5
249	R:R:L117	R:R:L128	2.77	No	No	0	6	3
250	R:R:L183	R:R:L245	2.77	No	No	0	4	6
251	R:R:L52	R:R:N50	2.75	No	No	0	8	7
252	R:R:L304	R:R:N303	2.75	No	No	0	4	3
253	R:R:F274	R:R:V235	2.62	No	No	0	7	5
254	R:R:A300	R:R:W40	2.59	No	Yes	0	3	4
255	R:R:R130	R:R:T133	2.59	No	No	0	6	3
256	R:R:R160	R:R:T166	2.59	No	No	0	1	3
257	R:R:Q45	R:R:Q48	2.56	No	No	0	5	7
258	R:R:H79	R:R:N82	2.55	No	No	0	4	5
259	R:R:V233	R:R:W194	2.45	No	No	0	9	6
260	R:R:I204	R:R:Y116	2.42	No	Yes	0	6	8
261	R:R:I204	R:R:Y201	2.42	No	Yes	0	6	8
262	R:R:D161	R:R:F159	2.39	No	No	0	2	2
263	R:R:N164	R:R:Y163	2.33	No	No	0	4	3
264	R:R:A38	R:R:P283	1.87	No	No	0	9	9
265	R:R:G292	R:R:S295	1.86	No	No	0	6	4
266	R:R:A38	R:R:C287	1.81	No	No	0	9	8
267	R:R:A41	R:R:C287	1.81	No	No	0	7	8
268	R:R:A120	R:R:A207	1.79	No	No	0	7	3
269	R:R:C109	R:R:V113	1.71	No	No	0	8	6
270	R:R:A267	R:R:S266	1.71	No	No	0	5	2
271	R:R:A106	R:R:V141	1.7	No	No	0	6	7
272	R:R:G292	R:R:N290	1.7	No	No	0	6	8
273	R:R:E291	R:R:G292	1.64	No	No	0	5	6
274	R:R:S246	R:R:V242	1.62	No	No	0	4	6
275	R:R:V135	R:R:V54	1.6	No	No	0	4	5
276	R:R:V119	R:R:V208	1.6	No	No	0	8	8
277	R:R:C36	R:R:L32	1.59	No	No	0	3	6
278	R:R:C36	R:R:L64	1.59	No	No	0	3	8
279	R:R:T133	R:R:V137	1.59	No	No	0	3	5
280	R:R:T144	R:R:V141	1.59	No	No	0	5	7
281	R:R:A226	R:R:L205	1.58	No	No	0	7	5
282	R:R:A300	R:R:L301	1.58	No	No	0	3	6
283	R:R:I25	R:R:S22	1.55	No	No	0	4	5
284	R:R:I284	R:R:V289	1.54	No	No	0	7	6
285	R:R:H121	R:R:P122	1.53	No	No	0	6	7
286	R:R:M174	R:R:V178	1.52	No	No	0	1	2
287	R:R:G203	R:R:R206	1.5	No	No	0	3	3
288	R:R:G210	R:R:R209	1.5	No	No	0	4	4
289	R:R:L18	R:R:V15	1.49	No	No	0	4	4
290	R:R:D16	R:R:S270	1.47	Yes	No	0	5	5
291	R:R:I61	R:R:M57	1.46	No	Yes	0	5	5
292	R:R:F19	R:R:P20	1.44	No	Yes	0	5	5
293	R:R:I230	R:R:L227	1.43	Yes	No	0	7	5
294	R:R:A118	R:R:R129	1.38	No	No	0	8	7
295	R:R:D156	R:R:K171	1.38	No	No	0	5	3
296	R:R:L183	R:R:L252	1.38	No	No	0	4	6
297	R:R:F187	R:R:V188	1.31	No	No	0	5	4
298	R:R:F260	R:R:V264	1.31	Yes	Yes	0	1	4
299	R:R:H302	R:R:K299	1.31	No	No	0	5	5
300	R:R:E215	R:R:Q217	1.27	No	No	0	3	4
301	R:R:F19	R:R:L18	1.22	No	No	0	5	4
302	R:R:L199	R:R:R202	1.21	No	No	0	4	3
303	R:R:Q47	R:R:R44	1.17	No	No	0	6	4
304	R:R:H10	R:R:Y163	1.09	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V11	8.02	4	1	3
2	R:R:D16	8.055	4	0	5
3	R:R:P20	5.836	5	0	5
4	R:R:Y24	6.636	5	0	9
5	R:R:W40	6.0275	4	0	4
6	R:R:E51	8.7075	4	2	7
7	R:R:Y55	6.245	6	2	7
8	R:R:L56	4.27	4	2	8
9	R:R:M57	3.59	4	0	5
10	R:R:D63	6.12	5	2	9
11	R:R:Y66	6.94167	6	0	7
12	R:R:W73	8.432	5	1	7
13	R:R:Y76	9.1825	4	1	6
14	R:R:W83	5.93857	7	1	9
15	R:R:H85	6.815	4	1	7
16	R:R:F97	8.945	4	0	7
17	R:R:Y102	8.76	4	0	7
18	R:R:L108	5.56	4	2	8
19	R:R:I111	4.73	4	2	9
20	R:R:Y116	5.2375	4	0	8
21	R:R:W142	7.1675	4	3	9
22	R:R:E145	9.795	4	4	7
23	R:R:F167	7.8025	4	1	1
24	R:R:F172	10.396	5	1	5
25	R:R:P173	5.825	4	1	4
26	R:R:W177	10.9175	4	0	1
27	R:R:Y201	5.435	8	5	8
28	R:R:I230	4.16	4	0	7
29	R:R:F237	9.43	4	0	8
30	R:R:Y240	9.265	4	0	6
31	R:R:H241	8.4925	4	0	8
32	R:R:C258	5.29	4	1	8
33	R:R:F260	8.6225	4	0	1
34	R:R:V264	9.2075	4	1	4
35	R:R:F265	7.84333	6	1	4
36	R:R:H269	8.674	5	1	5
37	R:R:D282	8.4275	4	2	9
38	R:R:L285	3.57	4	0	5
39	R:R:Y286	6.2	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F172	R:R:V11	11.4071	10.49	Yes	Yes	1	5	3
2	R:R:F265	R:R:V11	29.1397	7.87	Yes	Yes	1	4	3
3	R:R:D16	R:R:H269	10.0606	13.87	Yes	Yes	0	5	5
4	R:R:F265	R:R:H269	17.9375	6.79	Yes	Yes	1	4	5
5	R:R:D16	R:R:P20	11.5593	8.05	Yes	Yes	0	5	5
6	R:R:F77	R:R:H269	27.4595	9.05	No	Yes	0	5	5
7	R:R:F77	R:R:P20	42.1304	10.11	No	Yes	0	5	5
8	R:R:F19	R:R:P20	14.6767	1.44	No	Yes	0	5	5
9	R:R:F19	R:R:L18	11.7525	1.22	No	No	0	5	4
10	R:R:A273	R:R:P20	20.5076	3.74	No	Yes	0	5	5
11	R:R:A273	R:R:L23	17.5951	3.15	No	No	0	5	5
12	R:R:L23	R:R:L277	14.6767	4.15	No	No	0	5	5
13	R:R:F77	R:R:Y24	65.3485	7.22	No	Yes	0	5	9
14	R:R:L70	R:R:Y24	23.2357	9.38	No	Yes	0	8	9
15	R:R:F97	R:R:Y24	25.3578	5.16	Yes	Yes	0	7	9
16	R:R:F97	R:R:W73	41.9577	11.02	Yes	Yes	0	7	7
17	R:R:W73	R:R:Y76	15.3324	11.58	Yes	Yes	1	7	6
18	R:R:D81	R:R:Y76	11.0119	10.34	No	Yes	1	4	6
19	R:R:F167	R:R:Y76	12.8297	5.16	Yes	Yes	1	1	6
20	R:R:S276	R:R:Y24	22.6912	7.63	No	Yes	0	7	9
21	R:R:N35	R:R:P283	31.6219	11.4	No	No	0	9	9
22	R:R:D63	R:R:N35	40.5761	12.12	Yes	No	0	9	9
23	R:R:C279	R:R:D63	99.5141	4.67	No	Yes	0	9	9
24	R:R:C279	R:R:Y66	100	4.03	No	Yes	0	9	7
25	R:R:L70	R:R:Y66	25.7179	9.38	No	Yes	0	8	7
26	R:R:F97	R:R:Y66	63.5454	10.32	Yes	Yes	0	7	7
27	R:R:S276	R:R:Y66	23.9323	3.82	No	Yes	0	7	7
28	R:R:A38	R:R:P283	23.7889	1.87	No	No	0	9	9
29	R:R:A38	R:R:C287	22.4775	1.81	No	No	0	9	8
30	R:R:A41	R:R:C287	13.5439	1.81	No	No	0	7	8
31	R:R:A41	R:R:D296	12.2969	4.63	No	No	0	7	4
32	R:R:R247	R:R:Y268	14.6533	12.35	No	No	0	4	5
33	R:R:L244	R:R:Y268	14.2054	5.86	No	No	0	5	5
34	R:R:L244	R:R:Y240	14.6591	7.03	No	Yes	0	5	6
35	R:R:H241	R:R:Y240	16.7316	9.8	Yes	Yes	0	8	6
36	R:R:F190	R:R:H241	13.6902	11.31	No	Yes	0	8	8
37	R:R:F190	R:R:F237	14.8494	4.29	No	Yes	0	8	8
38	R:R:F237	R:R:N278	21.8628	12.08	Yes	No	0	8	9
39	R:R:D282	R:R:N278	21.213	13.46	Yes	No	0	9	9
40	R:R:D282	R:R:L108	57.9926	5.43	Yes	Yes	2	9	8
41	R:R:L108	R:R:Y286	45.8449	7.03	Yes	Yes	2	8	9
42	R:R:I111	R:R:Y286	26.3238	6.04	Yes	Yes	2	9	9
43	R:R:I111	R:R:Y55	27.7259	4.84	Yes	Yes	2	9	7
44	R:R:A134	R:R:Y55	12.9204	5.34	No	Yes	2	5	7
45	R:R:A134	R:R:V54	11.852	3.39	No	No	0	5	5
46	R:R:E145	R:R:Y102	13.822	6.73	Yes	Yes	0	7	7
47	R:R:H241	R:R:Y102	11.811	8.71	Yes	Yes	0	8	7
48	R:R:D63	R:R:L59	41.4396	4.07	Yes	No	2	9	9
49	R:R:I101	R:R:Y102	24.1372	7.25	No	Yes	0	8	7
50	R:R:H85	R:R:W83	14.9606	4.23	Yes	Yes	1	7	9
51	R:R:D75	R:R:H85	12.7009	13.87	No	Yes	0	4	7
52	R:R:D75	R:R:H79	11.4568	5.04	No	No	0	4	4
53	R:R:C90	R:R:L158	12.8004	4.76	No	No	0	9	5
54	R:R:L158	R:R:P87	10.6811	3.28	No	No	0	5	3
55	R:R:L108	R:R:M197	52.1266	4.24	Yes	No	0	8	7
56	R:R:M197	R:R:Y201	50.9411	3.59	No	Yes	0	7	8
57	R:R:I204	R:R:Y116	21.1018	2.42	No	Yes	0	6	8
58	R:R:I204	R:R:Y201	38.0441	2.42	No	Yes	0	6	8
59	R:R:H121	R:R:Y116	10.6929	7.62	No	Yes	0	6	8
60	R:R:I204	R:R:V119	16.4418	4.61	No	No	0	6	8
61	R:R:H241	R:R:V186	10.3826	4.15	Yes	No	0	8	4
62	R:R:I230	R:R:Y201	12.051	3.63	Yes	Yes	0	7	8
63	R:R:L229	R:R:Y286	13.2248	8.21	No	Yes	0	8	9
64	R:R:V119	R:R:V208	14.9489	1.6	No	No	0	8	8
65	R:R:K219	R:R:V208	12.0745	4.55	No	No	0	6	8
66	R:R:K219	R:R:T214	10.6929	9.01	No	No	0	6	3
67	R:R:L229	R:R:L285	12.0335	4.15	No	Yes	0	8	5
68	R:R:F274	R:R:L277	11.7525	3.65	No	No	0	7	5
69	R:R:L108	R:R:L59	40.8512	5.54	Yes	No	2	8	9
70	R:R:D282	R:R:D63	44.8731	5.32	Yes	Yes	2	9	9
71	R:R:V11	R:R:V264	11.3602	8.02	Yes	Yes	1	3	4
72	R:R:I101	R:R:Y66	24.225	3.63	No	Yes	0	8	7
73	R:R:F237	R:R:I101	11.1436	8.79	Yes	No	0	8	8
74	R:R:W73	R:R:W83	18.9562	7.5	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8Z65_nogp

PDB Summary
PDB	8Z65_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	278
Number of Links	304
Number of Hubs	39
Number of Links mediated by Hubs	143
Number of Communities	5
Number of Nodes involved in Communities	39
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	69779
Length Of Smallest Path	3
Average Path Length	13.2684
Length of Longest Path	28
Minimum Path Strength	1.33
Average Path Strength	6.39022
Maximum Path Strength	17.19
Minimum Path Correlation	0.7
Average Path Correlation	0.931187
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	53.4916
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3084
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46093
Sequence	>8Z65_nogp_Chain_R G C H V D S R V D H L F P P S L Y I V I G V G L P T N C L A L W A A Y R Q V Q Q R N E L G Y L M L S I A D L Y I C T L P W V D Y F H H D N W I H G P G S C K L F F I F Y T N I Y I S I A F L C C I V D R Y L A V A H P L R F R L R R V T V A V S S V V W A T E L G A N S A P L F H D E L F R D R Y N H T C F E K F P M G W V A W M N L Y R F V G F F P W A M L S Y R L R V R G S V S T E R Q E K A K I K L A L S L A I V L V C F A P Y H V L L S R S A I Y R P W D C G F E E R V F S A Y H S S A F T S L N C V D P I Y L V N E G A R S D A K A L H N L F V N L L L G S A K A F V L L L G I A R I L L L A L C V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8Z3M	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-04-23	To be published
	8Z3M (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	To be published
	8Z3Q	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-04-23	To be published
	8Z3Q (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.76	2025-04-23	To be published
	8Z65	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-04-23	To be published
	8Z65 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.98	2025-04-23	To be published
	8Z66	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.06	2025-04-23	To be published
	8Z67	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-04-23	To be published
	8ZCE	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCE (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFU	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	3.23	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8Z3Y	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2025-06-04	To be published
	8Z3Y (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.2	2025-06-04	To be published
	9LMP	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	2.65	2025-07-02	To be published
	8Z9P	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gi1/β1/γ2	2.5	2025-07-09	To be published
	8Z9P (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.5	2025-07-09	To be published
	9JCO	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCP	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9LMO	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-07-09	To be published
	8Z9O	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.4	2025-07-16	To be published
	8Z9O (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.4	2025-07-16	To be published
	9IV6	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.71	2025-07-30	To be published
	9IV6 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.71	2025-07-30	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z65_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.