Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 7.12833614
2A:A:L44 9.855419
3A:A:N50 4.268564
4A:A:S51 2.5025409
5A:A:Y63 3.9375409
6A:A:I207 7.1419
7A:A:F212 7.8154239
8A:A:H220 14.14417
9A:A:M221 6.53254238
10A:A:V224 5.4125419
11A:A:R231 5.3025419
12A:A:R232 11.8525408
13A:A:K233 5.25419
14A:A:W234 10.0029719
15A:A:C237 4.5875418
16A:A:F238 11.495419
17A:A:F246 5.9185129
18A:A:V247 4.05467
19A:A:S251 3.76469
20A:A:Y253 7.44568
21A:A:F273 6.017147129
22A:A:W277 7.4985126
23A:A:W281 7.158515
24A:A:L289 4.9085129
25A:A:F290 5.606569
26A:A:K293 7.0375469
27A:A:F315 7.61506
28A:A:E330 9.165253
29A:A:D331 10.74254244
30A:A:F340 6.358507
31A:A:R342 7.55254184
32A:A:F345 6.41754128
33A:A:C359 4.86754125
34A:A:Y360 6.528577118
35A:A:N371 4.69667669
36A:A:R373 8.074175
37A:A:F376 6.4925178
38A:A:I382 3.9154116
39A:A:R385 7.15115
40A:A:Y391 7.316676214
41B:B:R22 7.8625436
42B:B:H54 7.823336139
43B:B:L55 9.41416
44B:B:K57 16.7475419
45B:B:I58 7.094139
46B:B:W63 9.95507
47B:B:Q75 9.754519
48B:B:L79 6.8825497
49B:B:I80 6.62754138
50B:B:I81 6.32254227
51B:B:W82 8.14758139
52B:B:K89 9.1125409
53B:B:H91 6.415405
54B:B:I93 4.6925497
55B:B:L95 7.044598
56B:B:W99 8.465619
57B:B:Y105 6.0356226
58B:B:Y111 10.0954154
59B:B:C114 4.692598
60B:B:L117 4.704519
61B:B:S122 4.3025498
62B:B:I123 5.126156
63B:B:Y124 5.62667696
64B:B:H142 8.0345149
65B:B:Y145 6.292518
66B:B:L146 4.374147
67B:B:F151 5.5865159
68B:B:L152 6.08643
69B:B:Q156 5.896545
70B:B:T159 4.542509
71B:B:S161 7.39754149
72B:B:D163 9.0525149
73B:B:W169 11.834148
74B:B:Q176 8.44144
75B:B:F180 10.0325447
76B:B:H183 9.736549
77B:B:V187 4.655449
78B:B:L192 7.57445
79B:B:F199 8.36167649
80B:B:V200 5.8175436
81B:B:C204 4.9925417
82B:B:D205 6.0925449
83B:B:K209 10.53546
84B:B:L210 5.154505
85B:B:W211 10.2386748
86B:B:R214 7.828549
87B:B:F222 4.85538
88B:B:H225 8.62333639
89B:B:D228 5.534519
90B:B:I229 5.8825437
91B:B:I232 5.3325438
92B:B:F234 6.4375405
93B:B:F235 6.61726
94B:B:F241 6.795636
95B:B:T243 6.15538
96B:B:D247 7.315439
97B:B:R251 14.705438
98B:B:L252 5.2375427
99B:B:F253 7.755436
100B:B:D258 7.942537
101B:B:Q259 4.02406
102B:B:M262 5.39424
103B:B:Y264 6.545625
104B:B:I269 4.66424
105B:B:S277 4.0975405
106B:B:F278 8.324527
107B:B:R283 6.25199
108B:B:L284 5.0425405
109B:B:L285 6.485426
110B:B:L286 5.94107
111B:B:Y289 7.355627
112B:B:C294 3.925105
113B:B:N295 7.668526
114B:B:W297 9.95528
115B:B:L300 5.0425196
116B:B:K301 5.412867195
117B:B:H311 9.8645109
118B:B:R314 12.88518
119B:B:V315 4.39254107
120B:B:M325 5.694205
121B:B:V327 4.3575406
122B:B:W332 15.576519
123B:B:D333 8.60254109
124B:B:L336 3.81754137
125B:B:K337 10.7754106
126B:B:W339 13.1465109
127G:G:R27 6.595408
128G:G:M38 2.3404
129G:G:Y40 9.875426
130G:G:D48 4.9725409
131G:G:L51 4.6975406
132G:G:N59 4.6945209
133G:G:F61 4.979208
134R:R:D24 6.085475
135R:R:Q28 7.138575
136R:R:Y32 9.638578
137R:R:G39 2.6975408
138R:R:W48 7.5554163
139R:R:E59 5.9054216
140R:R:L60 5.115407
141R:R:I62 4.9075407
142R:R:Y63 4.482507
143R:R:N66 9.285489
144R:R:L67 5.05489
145R:R:D71 6.385489
146R:R:I75 5.044506
147R:R:W81 8.036576
148R:R:F85 8.212575
149R:R:K99 8.73407
150R:R:F103 8.515405
151R:R:F105 9.134576
152R:R:I109 6.0575457
153R:R:F115 8.2125487
154R:R:Y124 4.77507
155R:R:W150 7.994589
156R:R:D164 6.12405
157R:R:F175 9.672574
158R:R:K179 8.945404
159R:R:Y180 8.86474
160R:R:M182 5.8375452
161R:R:E183 9.195453
162R:R:W185 11.21551
163R:R:V186 8.5275454
164R:R:M189 4.34455
165R:R:R193 12.235405
166R:R:F198 6.455658
167R:R:P201 3.2725409
168R:R:W202 5.77333606
169R:R:Y209 5.416509
170R:R:I212 4.42408
171R:R:K227 7.17406
172R:R:L237 5.9925407
173R:R:F245 10.658558
174R:R:Y248 7.964557
175R:R:L251 3.875455
176R:R:L252 6.145456
177R:R:R255 6.188554
178R:R:F259 8.23453
179R:R:E269 5.4403
180R:R:E270 5.055404
181R:R:L272 3.905455
182R:R:F273 8.222574
183R:R:Y276 8.42455
184R:R:H277 8.22475
185R:R:D290 6.538589
186R:R:Y294 8.106589
187R:R:N298 5.73408
188R:R:V305 3.0875405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:S316 B:B:W332 45.07913.71NoYes099
2B:B:C317 B:B:S316 44.95313.44NoNo079
3B:B:C317 B:B:M61 44.87144.86NoNo076
4B:B:M61 B:B:W63 10.35363.49NoYes067
5B:B:D118 B:B:W99 10.19854.47NoYes199
6A:A:F290 A:A:V247 89.63313.93YesYes697
7A:A:N292 A:A:V247 93.90754.43NoYes697
8A:A:K293 A:A:N292 95.44345.6YesNo699
9A:A:K293 A:A:S251 95.313.06YesYes699
10A:A:K300 A:A:S251 97.14043.06NoYes699
11A:A:K300 A:A:Y253 97.224814.33NoYes698
12A:A:L297 A:A:Y253 96.46443.52NoYes088
13A:A:L297 A:A:S250 96.58829.01NoNo086
14A:A:Q294 A:A:S250 96.962910.11NoNo066
15A:A:L291 A:A:Q294 99.87773.99NoNo086
16A:A:L289 A:A:L291 1005.54YesNo098
17A:A:F246 A:A:L289 78.83153.65YesYes1299
18A:A:D272 A:A:F246 81.32325.97NoYes089
19A:A:D272 A:A:R232 81.39797.15NoYes088
20A:A:R232 A:A:W234 84.225514.99YesYes089
21A:A:F273 A:A:L289 22.88156.09YesYes1299
22A:A:F273 A:A:V287 26.33433.93YesNo096
23A:A:I244 A:A:V287 27.77063.07NoNo086
24A:A:W234 B:B:L117 67.18453.42YesYes199
25B:B:L117 B:B:Y145 73.54435.86YesYes198
26A:A:I235 A:A:W234 20.55623.52NoYes199
27A:A:I235 A:A:W281 20.17584.7NoYes195
28A:A:N239 B:B:W332 39.14357.91NoYes089
29A:A:I244 A:A:L282 20.71725.71NoNo089
30A:A:F290 A:A:R374 85.33365.34YesNo094
31A:A:H362 A:A:R374 85.091530.47NoNo094
32A:A:D378 A:A:H362 84.950511.35NoNo079
33A:A:D378 A:A:Y360 86.124912.64NoYes078
34A:A:I382 A:A:Y360 68.16234.84YesYes1168
35A:A:R385 R:R:S221 17.30365.27YesNo1154
36A:A:Y360 R:R:S221 17.36595.09YesNo1184
37A:A:I382 A:A:M386 67.88511.46YesNo063
38A:A:I383 A:A:M386 67.7361.46NoNo083
39A:A:H387 A:A:I383 67.20766.63NoNo088
40A:A:R385 R:R:T222 17.1745.17YesNo054
41A:A:H387 R:R:R137 67.05636.77NoNo086
42A:A:L388 R:R:V216 12.75825.96NoNo088
43R:R:K227 R:R:V216 12.88994.55YesNo068
44R:R:K227 R:R:T222 16.908310.51YesNo064
45R:R:E59 R:R:R137 60.88968.14YesNo2166
46B:B:G162 B:B:Y145 73.62125.79NoYes098
47B:B:G162 B:B:S161 73.64263.71NoYes099
48B:B:H142 B:B:S161 35.728612.55YesYes1499
49B:B:H142 B:B:T165 36.99515.48YesNo1497
50B:B:T165 B:B:T181 72.20534.71NoNo072
51B:B:G182 B:B:T181 72.09843.64NoNo062
52B:B:G182 B:B:K209 71.99533.49NoYes066
53B:B:K209 B:B:W211 69.376111.6YesYes468
54B:B:F199 B:B:W211 68.71315.03YesYes498
55B:B:F199 B:B:V158 34.38917.87YesNo495
56B:B:L152 B:B:V158 34.26935.96YesNo435
57B:B:L152 B:B:R214 66.19833.64YesYes439
58B:B:E215 B:B:R214 53.44894.65NoYes039
59B:B:D212 B:B:E215 52.69189.09NoNo093
60B:B:D212 B:B:L198 26.22145.43NoNo093
61B:B:L198 B:B:L210 25.9448.3NoYes035
62B:B:L210 B:B:Q220 29.76573.99YesNo057
63B:B:D258 B:B:Q220 24.633613.05YesNo377
64B:B:D258 G:G:R27 10.57069.53YesYes078
65B:B:D163 B:B:S161 35.41168.83YesYes1499
66B:B:D163 B:B:T165 35.320610.12YesNo1497
67B:B:F199 B:B:L192 34.86444.87YesYes495
68B:B:L152 B:B:L192 34.38565.54YesYes435
69B:B:D212 B:B:R219 26.221410.72NoNo095
70B:B:L210 B:B:R219 25.9444.86YesNo055
71B:B:D258 B:B:R22 15.52375.96YesYes376
72B:B:Q259 B:B:R22 11.81784.67YesYes066
73B:B:G319 B:B:M61 40.20473.49NoNo056
74B:B:G319 B:B:S277 40.12593.71NoYes055
75B:B:L318 B:B:S277 38.46386.01NoYes065
76B:B:L286 B:B:L318 36.04876.92YesNo1076
77B:B:L286 B:B:V296 37.59687.45YesNo075
78B:B:L284 B:B:V296 37.464.47YesNo055
79B:B:L284 B:B:S279 17.22254.5YesNo059
80B:B:S279 G:G:D48 17.13344.42NoYes099
81B:B:K280 G:G:D48 34.71324.15NoYes019
82B:B:K280 G:G:E47 34.31566.75NoNo013
83G:G:E47 G:G:H44 33.52228.62NoNo036
84G:G:H44 G:G:Y40 32.730113.07NoYes066
85B:B:F235 G:G:Y40 16.38814.13YesYes266
86B:B:F235 B:B:F278 15.607716.08YesYes267
87B:B:F278 B:B:L252 16.96214.87YesYes277
88B:B:L284 G:G:L51 19.91486.92YesYes056
89G:G:D48 G:G:L51 17.99265.43YesYes096
90B:B:P236 G:G:Y40 15.64458.34NoYes276
91B:B:F278 B:B:P236 15.43464.33YesNo277
92B:B:R197 B:B:R214 12.828615.99NoYes059
93B:B:D195 B:B:R197 12.5145.96NoNo055
94B:B:A193 B:B:D195 12.25693.09NoNo045
95B:B:A193 B:B:F234 12.00326.93NoYes045
96B:B:F234 B:B:V200 10.99275.24YesYes056
97B:B:I232 B:B:V200 13.80773.07YesYes386
98B:B:L210 B:B:V200 21.50164.47YesYes056
99B:B:F241 B:B:V200 17.471210.49YesYes366
100B:B:I232 B:B:T243 10.35846.08YesYes388
101B:B:F241 B:B:T243 10.75583.89YesYes368
102B:B:H225 B:B:T243 14.25518.21YesYes398
103B:B:F278 B:B:L285 13.144912.18YesYes276
104B:B:W297 B:B:Y264 17.36349.65YesYes285
105R:R:E59 R:R:Y63 58.8374.49YesYes067
106R:R:I119 R:R:Y63 48.59794.84NoYes097
107R:R:I119 R:R:Y294 48.19387.25NoYes899
108R:R:L116 R:R:Y294 50.99415.24NoYes889
109R:R:D290 R:R:L116 49.56435.43YesNo898
110R:R:D290 R:R:N286 27.565612.12YesNo099
111R:R:F245 R:R:N286 27.024715.71YesNo089
112R:R:F245 R:R:T283 13.54613.89YesNo587
113R:R:T283 R:R:Y248 13.39043.75NoYes577
114R:R:Y248 R:R:Y276 10.655710.92YesYes575
115R:R:D290 R:R:D71 22.34396.65YesYes899
116R:R:C287 R:R:D71 15.62024.67NoYes089
117A:A:N239 A:A:W281 39.28173.39NoYes085
118A:A:L282 A:A:N279 20.6694.12NoNo098
119A:A:N279 A:A:W281 20.48185.65NoYes185
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ZFZ
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Danio Rerio
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.3
Date 2025-01-22
D.O.I. doi.org/10.1038/s41467-025-55901-2
Net Summary
Imin 3.06
Number of Linked Nodes 882
Number of Links 1095
Number of Hubs 188
Number of Links mediated by Hubs 687
Number of Communities 29
Number of Nodes involved in Communities 270
Number of Links involved in Communities 387
Path Summary
Number Of Nodes in MetaPath 120
Number Of Links MetaPath 119
Number of Shortest Paths 1971993
Length Of Smallest Path 3
Average Path Length 40.1828
Length of Longest Path 77
Minimum Path Strength 1.295
Average Path Strength 6.86281
Maximum Path Strength 29.74
Minimum Path Correlation 0.7
Average Path Correlation 0.987452
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.04082
Average % Of Corr. Nodes 39.9912
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.0896
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • response to pH   • response to abiotic stimulus   • response to acidic pH   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ZFZ_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIHSGIF 
ETKFQVDKV NFHMFDVGG QRDERRKWI QCFNDVTAI IFVVSSYNR 
LQEALNFKS IWNNRWLRT ISVILFLNK QDLLAEKVL AGKSKIEDY 
FPEFARYTT PEDATPEPG EDPRVTRAK YFIRDEFLR ISTASGDGR 
HYCYPHFTC AVDTENRRF NDCRDIIQR MHLRQYELL DVSADAARS 
MDNYGGDDA I


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8ZFZ_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8ZFZ_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtE7FEL0
Sequence
>8ZFZ_Chain_R
CNVDSNIDQ FFQPTLYII VIVLGFPTN CMALWAAYM QVKQKNELG 
IYLMNLSIA DLLYITTLP LWIDYFVHH DNWIHGQVS CKLFGFIFY 
TNIYVSIAF LCCISVDRY LAVAHPLKF AKVRRVKTA LLVSAIVWL 
TEIVANSAP LFHDELFQD RFNHTFCFE KYPMEPWVA GMNLYRTFL 
GFLAPWGIM LAAYRGILR AVRGNVSTE RQEKAKIKR LALSLILIV 
LLCFAPYHV LLLWRSVLF LINPCDCGG EENLFGAYH VTLALTSLN 
CVADPILYC FVNEGARHD VGRALATLL GL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-2610.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-2610.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-2610.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-2610.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-2610.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-2610.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-2610.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-2610.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-2610.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-2610.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-2610.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-2610.1016/j.cell.2024.12.001
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-2610.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-2610.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-2610.1016/j.cell.2024.12.001
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZFJAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.12024-08-07To be published
8ZFJ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.12024-08-07To be published
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-2610.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-2610.1016/j.cell.2024.12.001




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