Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F21 3.2975406
2R:R:Y26 5.73508
3R:R:I30 3.98547
4R:R:L54 4.5025427
5R:R:V56 3.275456
6R:R:Y57 5.38407
7R:R:L58 5.325427
8R:R:Y68 6.61167605
9R:R:W75 10.712516
10R:R:Y78 8.228515
11R:R:F79 7.46514
12R:R:D83 6.9414
13R:R:W85 8.0825409
14R:R:F99 10.8516
15R:R:Y100 9.035415
16R:R:F109 8.2625437
17R:R:L110 4.9675428
18R:R:I113 5.82428
19R:R:Y118 5.9725408
20R:R:F127 4.0275405
21R:R:W144 4.635639
22R:R:H167 8.48513
23R:R:F169 8.446512
24R:R:F171 12.27404
25R:R:E172 8.68515
26R:R:F174 9.51614
27R:R:W179 11.17403
28R:R:Y203 5.92608
29R:R:L207 2.535404
30R:R:L231 5.094527
31R:R:F239 6.29333669
32R:R:Y242 7.68667607
33R:R:H243 8.6925408
34R:R:Y253 4.2275403
35R:R:Y270 7.2414
36R:R:H271 10.59414
37R:R:D284 7.632529
38R:R:Y288 6.845429
39R:R:C289 3.395406
40R:R:D298 3.7075405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D83 R:R:H82 12.00631.26YesNo144
2R:R:F79 R:R:P22 26.85518.67YesNo045
3R:R:F21 R:R:P22 13.52255.78YesNo065
4R:R:P22 R:R:P23 11.28175.84NoNo056
5R:R:F79 R:R:Y26 30.42225.16YesYes048
6R:R:L72 R:R:Y26 11.5178.21NoYes088
7R:R:F99 R:R:W75 11.450126.06YesYes166
8R:R:S278 R:R:Y26 12.26035.09NoYes068
9R:R:F99 R:R:Y68 26.939.28YesYes065
10R:R:E172 R:R:Y270 23.27994.49YesYes154
11R:R:Y242 R:R:Y270 40.727910.92YesYes074
12R:R:T277 R:R:Y242 43.61854.99NoYes087
13R:R:F239 R:R:T277 39.81075.19YesNo698
14R:R:F239 R:R:N280 1008.46YesNo099
15R:R:D284 R:R:N280 99.719213.46YesNo099
16R:R:D284 R:R:D65 12.3863.99YesNo099
17R:R:D65 R:R:N37 11.426114.81NoNo099
18R:R:F174 R:R:Y270 14.61884.13YesYes144
19R:R:D284 R:R:L110 90.57146.79YesYes298
20R:R:L110 R:R:Y288 64.18964.69YesYes289
21R:R:I113 R:R:Y288 32.6318.46YesYes289
22R:R:I113 R:R:L58 18.52024.28YesYes287
23R:R:C289 R:R:L58 17.83576.35YesYes067
24R:R:I113 R:R:L54 18.21274.28YesYes287
25R:R:D116 R:R:L54 15.68044.07NoYes087
26R:R:D116 R:R:Y57 12.11595.75NoYes087
27R:R:H243 R:R:Y242 17.08168.71YesYes087
28R:R:H243 R:R:Y104 25.94598.71YesNo087
29R:R:E147 R:R:Y104 27.52895.61NoNo077
30R:R:E147 R:R:I105 14.086717.76NoNo076
31R:R:I105 R:R:W144 12.83267.05NoYes069
32R:R:I103 R:R:Y68 51.43464.84NoYes075
33R:R:W85 R:R:Y78 12.097215.43YesYes095
34R:R:S91 R:R:W85 11.182.47NoYes049
35R:R:E147 R:R:N151 12.83266.57NoNo076
36R:R:N151 R:R:S101 11.57314.47NoNo065
37R:R:F97 R:R:S101 10.30837.93NoNo055
38R:R:L274 R:R:Y242 11.81917.03NoYes057
39R:R:L110 R:R:M199 27.37124.24YesNo087
40R:R:R117 R:R:Y288 14.16697.2NoYes299
41R:R:M199 R:R:S114 25.86846.13NoNo079
42R:R:S114 R:R:Y203 16.958610.17NoYes098
43R:R:R117 R:R:Y203 18.26358.23NoYes098
44R:R:L231 R:R:Y288 18.53097.03YesYes279
45R:R:L231 R:R:Y203 14.04665.86YesYes078
46R:R:C202 R:R:Y118 13.06254.03NoYes068
47R:R:C202 R:R:S114 14.84343.44NoNo069
48R:R:L246 R:R:Y242 19.72359.38NoYes067
49R:R:L246 R:R:N184 18.779615.1NoNo065
50R:R:N184 R:R:V180 16.87574.43NoNo055
51R:R:F192 R:R:H243 18.64059.05NoYes088
52R:R:I232 R:R:Y203 11.8784.84NoYes078
53R:R:A228 R:R:Y203 25.84164NoYes078
54R:R:A228 R:R:L207 23.49653.15NoYes074
55R:R:I224 R:R:L207 14.08131.43NoYes064
56R:R:I224 R:R:V210 11.90743.07NoNo068
57R:R:F99 R:R:Y26 16.15376.19YesYes068
58R:R:L72 R:R:Y68 13.88884.69NoYes085
59R:R:F239 R:R:I103 47.931710.05YesNo697
60R:R:S278 R:R:Y68 15.87296.36NoYes065
61R:R:F192 R:R:F239 18.91337.5NoYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ZFE
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.56
Date 2025-02-26
D.O.I. doi.org/10.1016/j.cell.2024.12.001
Net Summary
Imin 3.93
Number of Linked Nodes 263
Number of Links 299
Number of Hubs 40
Number of Links mediated by Hubs 150
Number of Communities 7
Number of Nodes involved in Communities 50
Number of Links involved in Communities 68
Path Summary
Number Of Nodes in MetaPath 62
Number Of Links MetaPath 61
Number of Shortest Paths 66616
Length Of Smallest Path 3
Average Path Length 13.6194
Length of Longest Path 26
Minimum Path Strength 1.27
Average Path Strength 6.98888
Maximum Path Strength 17.67
Minimum Path Correlation 0.7
Average Path Correlation 0.928734
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 49.8271
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.9408
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8BUD0
Sequence
>8ZFE_Chain_R
VDSRVDHLF PPSLYIFVI GVGLPTNCL ALWAAYRQV RQHNELGVY 
LMNLSIADL LYICTLPLW VDYFLHHDN WIHGPGSCK LFGFIFYSN 
IYISIAFLC CISVDRYLA VAHPLRFAR LRRVKTAVA VSSVVWATE 
LGANSAPLF HDELFRDRY NHTFCFEKF PMERWVAWM NLYRVFVGF 
LFPWALMLL CYRGILRAV QSSVSTERQ EKVKIKRLA LSLIAIVLV 
CFAPYHALL LSRSAVYLG RPWDCGFEE RVFSAYHSS LAFTSLNCV 
ADPILYCLV NEGARSDVA KALHN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZFE.zip



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