Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N23 7.4325447
2A:A:H41 5.354526
3A:A:R42 6.02419
4A:A:L45 4.915428
5A:A:V217 4.8425
6A:A:F219 5.374528
7A:A:H220 9.835417
8A:A:M221 6.556528
9A:A:F222 9.0925417
10A:A:Q227 4.43333619
11A:A:R228 4.218509
12A:A:K233 5.4225819
13A:A:W234 6.07619
14A:A:C237 4.785418
15A:A:F238 8.95409
16A:A:I245 3.28427
17A:A:L270 6.0825406
18A:A:F273 6.1465149
19A:A:W277 8.121676146
20A:A:W281 10.845615
21A:A:L282 5.29409
22A:A:L289 5.2225409
23A:A:F290 4.78254119
24A:A:L297 4.115408
25A:A:F312 4.825178
26A:A:F315 6.502506
27A:A:P321 4.482505
28A:A:E330 6.8454123
29A:A:D331 8.0145124
30A:A:V334 6.034124
31A:A:Y339 6.741676133
32A:A:F340 8.2945177
33A:A:R342 5.5154134
34A:A:E344 7.9854175
35A:A:F345 9.02408
36A:A:I348 6.244144
37A:A:R356 7.251676182
38A:A:Y360 10.9565108
39A:A:F363 8.1325135
40A:A:T364 6.73254119
41A:A:D368 7.834119
42A:A:R374 9.41754114
43A:A:F376 6.99628
44A:A:D381 6.25754108
45A:A:I383 4.26628
46A:A:R385 6.683336105
47A:A:H387 5.048528
48A:A:L388 3.9854198
49A:A:Y391 6.61125824
50B:B:L7 4.5825408
51B:B:L14 4.7425408
52B:B:I33 3.535403
53B:B:T34 5.23485
54B:B:I37 5.112582
55B:B:V40 6.0075483
56B:B:I43 3.7375483
57B:B:M45 4.9625404
58B:B:H54 8.40167649
59B:B:L55 7.265406
60B:B:K57 11.058519
61B:B:Y59 9.9875418
62B:B:M61 3.446506
63B:B:W63 8.58167647
64B:B:L70 8.0975445
65B:B:V71 4.54478
66B:B:Q75 7.595419
67B:B:D76 7.595449
68B:B:L79 4.73577
69B:B:W82 9.25143749
70B:B:D83 9.325448
71B:B:T86 6.8225446
72B:B:K89 5.43749
73B:B:I93 5.24407
74B:B:L95 5.1575478
75B:B:W99 9.23571719
76B:B:M101 5.6275419
77B:B:C103 4.305478
78B:B:Y105 4.00429776
79B:B:N110 6.5554154
80B:B:Y111 5.7385154
81B:B:L117 3.668519
82B:B:I123 3.8675406
83B:B:Y124 5.978576
84B:B:E138 3.7675406
85B:B:L139 8.7075409
86B:B:H142 6.98857719
87B:B:Y145 7.07429718
88B:B:F151 5.624509
89B:B:S160 5.1725466
90B:B:S161 8.44419
91B:B:D163 8.23519
92B:B:C166 4.022568
93B:B:W169 9.065618
94B:B:F180 9.338567
95B:B:H183 8.09669
96B:B:D186 5.696519
97B:B:V187 5.145469
98B:B:M188 4.86418
99B:B:L190 4.284565
100B:B:F199 7.988569
101B:B:V200 7.43456
102B:B:S201 4.716569
103B:B:C204 6.5517
104B:B:D205 7.7375469
105B:B:S207 4.47465
106B:B:K209 8.80667666
107B:B:L210 5.355405
108B:B:W211 9.596568
109B:B:Q220 8.6175457
110B:B:F222 8.6275458
111B:B:H225 9.6659
112B:B:D228 9.445419
113B:B:I232 6.2425458
114B:B:F235 5.88429716
115B:B:P236 5.655417
116B:B:F241 7.848556
117B:B:T243 6.9625458
118B:B:D247 7.714559
119B:B:R251 11.772558
120B:B:F253 7.456556
121B:B:D254 4.305409
122B:B:D258 9.496557
123B:B:E260 9.0325456
124B:B:M262 6.465414
125B:B:Y264 6.53833615
126B:B:I269 3.285414
127B:B:T274 4.33418
128B:B:F278 4.86617
129B:B:R283 7.622589
130B:B:L284 4.962585
131B:B:L285 5.4925416
132B:B:Y289 7.22717
133B:B:D290 6.378516
134B:B:C294 4.2425405
135B:B:N295 7.526516
136B:B:W297 7.53418
137B:B:L300 5.034586
138B:B:H311 8.57599
139B:B:R314 14.544518
140B:B:L318 3.94167696
141B:B:M325 7.72445
142B:B:V327 3.585496
143B:B:W332 10.7343719
144B:B:D333 10.7975499
145B:B:L336 4.608547
146B:B:K337 5.706596
147B:B:I338 4.79445
148B:B:W339 8.964599
149B:B:N340 8.66833649
150G:G:V16 3407
151G:G:I28 6.2625404
152G:G:M38 3.2975484
153G:G:Y40 12.3775416
154G:G:D48 5.822509
155G:G:P49 5.62447
156G:G:L51 4.05586
157G:G:P60 7.4625449
158G:G:F61 6.80571748
159R:R:C9 5.8025438
160R:R:D16 5.5225435
161R:R:F19 5.74435
162R:R:P21 5.51437
163R:R:L23 5.68435
164R:R:Y24 8.3525409
165R:R:I28 3.5725217
166R:R:G31 1.88254208
167R:R:N35 5.938509
168R:R:N50 6.1925427
169R:R:E51 5.928527
170R:R:L52 5.212528
171R:R:V54 3.268527
172R:R:Y55 5.54167627
173R:R:L56 3.485428
174R:R:D63 5.64529
175R:R:Y66 8.662507
176R:R:L70 7.22408
177R:R:W73 7.742537
178R:R:Y76 9.45436
179R:R:F77 6.665635
180R:R:D81 7.844534
181R:R:W83 6.9075839
182R:R:K91 3.42436
183R:R:F95 8.1425426
184R:R:F97 10.514507
185R:R:T99 6.5825425
186R:R:N100 4.3625408
187R:R:Y102 9.0275407
188R:R:F107 8.092528
189R:R:L108 6.02528
190R:R:I111 4.122529
191R:R:R115 6.5575409
192R:R:P122 4.2325427
193R:R:L123 4.74333626
194R:R:R129 5.0825427
195R:R:R130 4.4175406
196R:R:V131 3.1625423
197R:R:W142 6.694529
198R:R:E145 3.8475407
199R:R:L146 3.585423
200R:R:E157 10.005435
201R:R:H165 8.4625431
202R:R:F167 9.6875434
203R:R:C168 6.7625439
204R:R:F169 8.18634
205R:R:F172 9.935635
206R:R:P173 4.0425434
207R:R:M174 5.485431
208R:R:W177 14.1125401
209R:R:N182 6.348535
210R:R:R185 6.82405
211R:R:W194 8.6654246
212R:R:Y201 5.53667608
213R:R:S213 5.29754103
214R:R:T214 6.434103
215R:R:F237 7.3225428
216R:R:Y240 7.35833636
217R:R:H241 10.6925408
218R:R:L244 7.4025435
219R:R:R247 6.548534
220R:R:Y251 6.285403
221R:R:C258 6.6525438
222R:R:F260 8.1775401
223R:R:E261 7.266534
224R:R:E262 6.155433
225R:R:V264 5.475404
226R:R:F265 9.048534
227R:R:Y268 8.40333635
228R:R:H269 9.18167635
229R:R:D282 8.4275429
230R:R:L285 4.355408
231R:R:Y286 7.365429
232R:R:C287 2.74507
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:K34 B:B:L55 1008.46NoYes046
2A:A:K34 A:A:R38 99.99162.48NoNo044
3A:A:R38 R:R:R130 99.98343.2NoYes046
4A:A:Y37 B:B:L55 75.08367.03NoYes046
5A:A:R42 A:A:Y37 75.05066.17YesNo094
6A:A:H41 A:A:I383 10.34145.3YesYes268
7A:A:H387 A:A:I383 17.21956.63YesYes288
8A:A:H387 R:R:R129 10.58097.9YesYes287
9R:R:E51 R:R:R129 17.25023.49YesYes277
10R:R:E51 R:R:T133 99.97582.82YesNo073
11R:R:R130 R:R:T133 99.96293.88YesNo063
12A:A:F222 A:A:R42 74.91883.21YesYes179
13A:A:F222 B:B:W99 50.514121.05YesYes179
14A:A:Q227 B:B:L117 48.63292.66YesYes199
15A:A:I207 B:B:L117 24.87352.85NoYes199
16A:A:F222 A:A:I207 24.87256.28YesNo179
17B:B:L117 B:B:W99 28.58546.83YesYes199
18A:A:V217 R:R:R124 10.38243.92YesNo054
19A:A:Q227 B:B:G144 57.00043.29YesNo198
20A:A:K233 A:A:Q236 18.94972.71YesNo198
21A:A:Q236 B:B:R314 12.031512.85NoYes188
22B:B:R314 B:B:T274 12.87775.17YesYes188
23B:B:T274 B:B:V315 13.08073.17YesNo087
24B:B:L308 B:B:M45 10.39835.65NoYes074
25A:A:R231 A:A:W234 16.45210NoYes099
26A:A:L272 A:A:R231 16.32438.5NoNo089
27A:A:W281 B:B:D290 21.78638.93YesYes156
28A:A:N279 A:A:W281 11.08463.39NoYes085
29A:A:L282 A:A:N279 11.02359.61YesNo098
30B:B:Q75 B:B:W99 22.42616.57YesYes199
31B:B:Q75 B:B:Y59 10.951311.27YesYes198
32B:B:K57 B:B:Q75 11.37539.49YesYes199
33B:B:R314 B:B:W332 12.893120.99YesYes189
34A:A:D378 A:A:Y360 23.435813.79NoYes078
35A:A:L388 A:A:L393 27.72444.15YesNo088
36A:A:L393 R:R:R115 27.619110.93NoYes089
37A:A:Y391 R:R:R115 17.08923.09YesYes049
38A:A:Y360 R:R:S213 18.30365.09YesYes1083
39A:A:R385 R:R:S213 19.43726.59YesYes1053
40A:A:L394 A:A:R385 20.40717.29NoYes085
41A:A:L394 R:R:I222 20.06162.85NoNo087
42A:A:L388 R:R:I222 19.81082.85YesNo1987
43R:R:I111 R:R:R115 24.10565.01YesYes099
44R:R:I111 R:R:Y55 53.69223.63YesYes297
45R:R:E51 R:R:Y55 76.94645.61YesYes277
46A:A:F246 A:A:L272 27.1476.09NoNo098
47A:A:F246 A:A:L289 27.28433.65NoYes099
48A:A:F290 A:A:T364 11.48766.49YesYes1199
49A:A:D378 A:A:H362 15.787212.61NoNo079
50A:A:F345 A:A:L289 12.31918.53YesYes089
51A:A:A366 A:A:C365 11.49221.81NoNo098
52A:A:C365 A:A:D368 13.40684.67NoYes089
53A:A:F273 A:A:F345 10.27367.5YesYes098
54A:A:C359 A:A:L289 16.69093.17NoYes059
55A:A:I276 A:A:L272 11.09854.28NoNo088
56A:A:I276 A:A:L282 10.96124.28NoYes089
57A:A:F273 A:A:W277 18.06195.01YesYes1496
58A:A:H357 A:A:W277 29.77322.22NoYes076
59A:A:G355 A:A:R385 28.21691.5NoYes025
60A:A:G355 A:A:R356 28.3411.5NoYes022
61A:A:H357 A:A:R356 29.55099.03NoYes072
62B:B:D163 B:B:G144 56.84535.03YesNo198
63B:B:D163 B:B:T165 44.91627.23YesNo197
64B:B:T165 B:B:T179 49.75763.14NoNo074
65B:B:T179 B:B:T181 49.86933.14NoNo042
66B:B:G182 B:B:T181 49.52293.64NoNo062
67B:B:G182 B:B:K209 49.17733.49NoYes066
68B:B:C218 B:B:K209 37.43696.47NoYes656
69B:B:C218 G:G:Q18 37.47826.1NoNo059
70G:G:M21 G:G:Q18 37.17554.08NoNo019
71B:B:M217 G:G:M21 36.81872.89NoNo031
72B:B:M217 B:B:R219 35.00919.93NoNo035
73B:B:L210 B:B:R219 33.94513.64YesNo055
74B:B:L210 B:B:Q220 32.89885.32YesYes057
75B:B:D258 B:B:Q220 15.899715.66YesYes577
76B:B:D258 B:B:R22 14.997311.91YesNo076
77B:B:I18 B:B:R22 13.8856.26NoNo076
78B:B:I18 G:G:A23 13.51383.25NoNo078
79B:B:Q17 G:G:A23 13.14234.55NoNo048
80B:B:L14 B:B:Q17 12.77062.66YesNo084
81B:B:H54 B:B:W82 18.17673.17YesYes499
82B:B:D76 B:B:H54 21.52715.04YesYes499
83B:B:L70 B:B:W82 16.92623.42YesYes459
84B:B:L70 B:B:W63 11.700721.64YesYes457
85B:B:D163 B:B:H142 16.168311.35YesYes199
86B:B:H142 B:B:W169 15.75973.17YesYes198
87B:B:G162 B:B:Y145 17.63498.69NoYes098
88B:B:G162 B:B:S161 17.09613.71NoYes099
89B:B:F222 B:B:Q220 15.53469.37YesYes587
90B:B:F222 B:B:F253 10.8737.5YesYes586
91B:B:C271 B:B:D290 32.5633.11NoYes156
92B:B:C271 B:B:Y289 30.41444.03NoYes157
93B:B:W297 B:B:Y289 22.53375.79YesYes187
94R:R:I111 R:R:Y286 65.42594.84YesYes299
95R:R:L108 R:R:Y286 69.32929.38YesYes289
96R:R:D282 R:R:L108 43.89399.5YesYes298
97R:R:D282 R:R:N278 18.863510.77YesNo299
98R:R:F237 R:R:N278 16.872912.08YesNo289
99R:R:F237 R:R:T275 14.59965.19YesNo088
100R:R:T275 R:R:Y240 14.41863.75NoYes086
101R:R:Y240 R:R:Y268 11.52697.94YesYes365
102R:R:C110 R:R:Y55 28.47528.06NoYes077
103R:R:C110 R:R:F107 28.31632.79NoYes078
104R:R:F107 R:R:W142 28.080910.02YesYes289
105R:R:L146 R:R:W142 23.02483.42YesYes239
106R:R:L146 R:R:T99 14.87964.42YesYes235
107R:R:N100 R:R:T99 10.82284.39YesYes085
108R:R:N100 R:R:Y66 10.34.65YesYes087
109R:R:F77 R:R:Y24 19.44318.25YesYes059
110R:R:D81 R:R:F167 11.77925.97YesYes344
111R:R:L108 R:R:L59 25.2175.54YesNo289
112R:R:D63 R:R:L59 25.05292.71YesNo299
113R:R:C279 R:R:D63 29.2456.22NoYes099
114R:R:C279 R:R:Y66 28.8779.41NoYes097
115R:R:D282 R:R:D63 25.20196.65YesYes299
116R:R:F97 R:R:Y66 21.209213.41YesYes077
117R:R:F97 R:R:W73 12.226920.04YesYes077
118R:R:D63 R:R:N35 21.87356.73YesYes099
119R:R:N35 R:R:S60 12.65482.98YesNo098
120R:R:L39 R:R:S60 12.23623NoNo078
121R:R:L39 R:R:M57 11.81745.65NoNo075
122R:R:M57 R:R:Y43 10.97924.79NoNo054
123A:A:K233 B:B:Y145 22.28013.58YesYes198
124B:B:W332 B:B:Y59 11.26938.68YesYes198
125B:B:K57 B:B:W332 10.966318.57YesYes199
126B:B:H142 B:B:S161 10.76716.74YesYes199
127B:B:D290 B:B:R314 14.208410.72YesYes168
128B:B:D76 B:B:L55 26.31679.5YesYes096
129B:B:W297 B:B:Y264 21.65058.68YesYes185
130A:A:H387 A:A:Y391 13.19623.27YesYes284
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z9O
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.4
Date 2025-07-16
D.O.I. To be published
Net Summary
Imin 2.66
Number of Linked Nodes 868
Number of Links 1161
Number of Hubs 232
Number of Links mediated by Hubs 809
Number of Communities 24
Number of Nodes involved in Communities 325
Number of Links involved in Communities 501
Path Summary
Number Of Nodes in MetaPath 131
Number Of Links MetaPath 130
Number of Shortest Paths 1895912
Length Of Smallest Path 3
Average Path Length 25.6185
Length of Longest Path 56
Minimum Path Strength 1.215
Average Path Strength 6.29607
Maximum Path Strength 22.875
Minimum Path Correlation 0.7
Average Path Correlation 0.986248
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 49.6366
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.6707
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • G-protein beta-subunit binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • ectodermal placode formation   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell-cell adhesion   • coagulation   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • cytoskeletal protein binding   • spectrin binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • cell population proliferation   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • cell projection membrane   • synapse   • cell junction   • cell body
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8Z9O_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAIVKQMSG 
IFETKFQVD KVNFHMFDV GQRDERRKW IQCFNDVTA IIFVVASSQ 
TNRLQALLF SIWNNWLRS VILFLNKQD LLAEKVLAK IEDYFPEFA 
RYTTPEDAT PEPGEDPRV TRAKYFIRD EFLRISTAS GDGRHYCYP 
HFTCAVDTE NIRRVFNDC RDIIQRMHL RQYELLAAK DKDT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8Z9O_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8Z9O_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>8Z9O_Chain_R
GCHVDSRVD HLFPPSLYI FVIGVGLPT NCLALWAAY RQVQQRNEL 
GVYLMNLSI ADLLYICTL PLWVDYFLH HDNWIHGPG SCKLFGFIF 
YTNIYISIA FLCCISVDR YLAVAHPLR FARLRRVKT AVAVSSVVW 
ATELGANSA PLFHDELFR DRYNHTFCF EKFPMEGWV AWMNLYRVF 
VGFLFPWAL MLLSYRGIL RAVRGSVST ERQEKAKIK RLALSLIAI 
VLVCFAPYH VLLLSRSAI YLGRPWDCG FEERVFSAY HSSLAFTSL 
NCVADPILY CLVNEGARS DVAKALHNL LRFLAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z9O.zip



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