Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L7 4.7425408
2B:B:E10 4.725408
3B:B:R22 6.85406
4B:B:T34 6.3325405
5B:B:L51 7.982579
6B:B:H54 9.64167679
7B:B:K57 10.302519
8B:B:M61 5.4325476
9B:B:W63 7.00167677
10B:B:L70 5.865475
11B:B:Q75 9.175619
12B:B:W82 9.68714779
13B:B:N88 5.2025407
14B:B:K89 8.874579
15B:B:H91 5.7725405
16B:B:I93 5.0475407
17B:B:L95 5.1525108
18B:B:W99 9.32333619
19B:B:Y105 4.838577106
20B:B:Y111 6.245404
21B:B:C114 3.54754108
22B:B:L117 4.1875419
23B:B:C121 4.5575488
24B:B:I123 3.578586
25B:B:Y124 4.776676106
26B:B:L139 8.8775489
27B:B:H142 9.118589
28B:B:Y145 6.682518
29B:B:C149 3.0525488
30B:B:R150 6.945446
31B:B:F151 6.89509
32B:B:L152 4.21833643
33B:B:T159 6.136589
34B:B:D163 8.1489
35B:B:L168 5.655446
36B:B:W169 10.065688
37B:B:Q176 7.628584
38B:B:F180 10.01547
39B:B:H183 9.224549
40B:B:D186 7.2175419
41B:B:L190 5.4175445
42B:B:F199 7.296549
43B:B:V200 7.9525456
44B:B:C204 6.495417
45B:B:K209 9.238546
46B:B:L210 4.795455
47B:B:W211 9.694548
48B:B:C218 5.72445
49B:B:F222 10.265458
50B:B:H225 11.1417659
51B:B:I229 7.045457
52B:B:F234 6.105405
53B:B:F235 7.7456116
54B:B:P236 5.66754117
55B:B:N237 7.5465115
56B:B:F241 8.682556
57B:B:D247 6.698559
58B:B:R251 13.84558
59B:B:F253 11.8825456
60B:B:D258 8.455457
61B:B:E260 8.745456
62B:B:Y264 6.61505
63B:B:S277 3.6625405
64B:B:F278 6.938336117
65B:B:R283 8.668569
66B:B:Y289 8.2065177
67B:B:D290 5.756516
68B:B:K301 5.44505
69B:B:H311 10.23569
70B:B:R314 12.722518
71B:B:L318 4.4045186
72B:B:M325 5.6725405
73B:B:W332 15.116519
74B:B:D333 10.71469
75B:B:L336 5.956577
76B:B:K337 8.592566
77B:B:I338 4.5025405
78B:B:W339 8.69833669
79A:A:T40 2.6025407
80A:A:H41 6.295436
81A:A:L44 10.4475419
82A:A:K53 5.46754199
83A:A:F212 5.9975409
84A:A:F219 7.355608
85A:A:M221 5.11408
86A:A:F222 10.046517
87A:A:R232 6.742518
88A:A:W234 6.1325819
89A:A:F238 9.55833619
90A:A:Y253 7.805408
91A:A:F273 5.98429
92A:A:W277 8.34667626
93A:A:W281 9.986515
94A:A:L282 6.3275419
95A:A:L289 5.266529
96A:A:F290 5.138336149
97A:A:N292 5.1154209
98A:A:K293 7.834209
99A:A:Q294 6.464526
100A:A:F312 5.19508
101A:A:F315 12.836526
102A:A:Y318 7.1426
103A:A:P321 5.0575425
104A:A:E330 6.964523
105A:A:D331 8.63404
106A:A:V334 4.24524
107A:A:K338 8.5825425
108A:A:Y339 7.5875423
109A:A:F340 11.1025427
110A:A:R342 7.204524
111A:A:F345 9.58428
112A:A:C359 4.905425
113A:A:Y360 10.2125408
114A:A:F363 9.775425
115A:A:D368 8.62754149
116A:A:F376 5.858508
117A:A:I383 4.568538
118A:A:R385 6.591676215
119A:A:H387 7.49438
120A:A:Y391 8.45375834
121R:R:Y32 6.345408
122R:R:N43 7.115409
123R:R:Q53 4.205404
124R:R:N58 5.7825437
125R:R:L60 5.18637
126R:R:I62 4.258507
127R:R:Y63 5.198507
128R:R:L64 4.754538
129R:R:D71 6.1125229
130R:R:Y74 4.1975406
131R:R:W81 5.8075496
132R:R:F101 4.81667695
133R:R:Y106 9.6365125
134R:R:T107 5.03754125
135R:R:N108 6.1408
136R:R:I109 5.2425407
137R:R:Y110 9.14254127
138R:R:F115 10.7854157
139R:R:I119 5.634539
140R:R:D122 7.316538
141R:R:R123 6.982539
142R:R:Y124 6.0854137
143R:R:H129 7.6154136
144R:R:L131 5.1075435
145R:R:R137 6.308536
146R:R:R138 4.634506
147R:R:N157 4.88254127
148R:R:Y180 4.095404
149R:R:R193 10.215125
150R:R:P201 2.8409
151R:R:W202 7.67506
152R:R:Y209 6.46143739
153R:R:I238 4.12407
154R:R:F245 9.09508
155R:R:Y248 6.64667697
156R:R:H249 8.562508
157R:R:C266 4.5475405
158R:R:F273 8.13494
159R:R:Y276 7.9475495
160R:R:H277 7.558595
161R:R:T279 3.8825406
162R:R:L293 4.6175407
163R:R:Y294 7.51667639
164R:R:C295 2.855406
165R:R:F296 4.27407
166G:G:Y40 6.0154116
167G:G:D48 7.87469
168G:G:L51 4.586566
169G:G:V54 4.7554236
170G:G:F61 5.554508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:R22 G:G:E22 85.22333.49YesNo069
2B:B:D258 B:B:R22 80.288710.72YesYes076
3B:B:D258 B:B:F222 76.00035.97YesYes578
4B:B:F222 B:B:F241 69.394210.72YesYes586
5B:B:F241 B:B:V200 67.768713.11YesYes566
6B:B:F234 B:B:V200 67.45526.55YesYes056
7B:B:F234 B:B:P194 66.46684.33YesNo054
8B:B:G238 B:B:P194 66.13734.06NoNo074
9B:B:G238 B:B:N237 65.80783.39NoYes075
10B:B:F235 B:B:N237 61.51668.46YesYes1165
11B:B:F235 B:B:F278 60.53210.72YesYes1167
12B:B:F278 B:B:L252 29.77413.65YesNo077
13B:B:L252 B:B:Y264 29.11357.03NoYes075
14B:B:M262 B:B:Y264 48.30859.58NoYes045
15B:B:L30 B:B:M262 46.98588.48NoNo054
16B:B:L30 B:B:T34 45.00175.9NoYes055
17B:B:F278 B:B:L285 29.774114.61YesNo076
18B:B:L285 B:B:Y264 29.11354.69NoYes065
19B:B:L300 B:B:T34 36.39995.9NoYes065
20B:B:L300 B:B:R283 35.07654.86NoYes669
21B:B:R283 G:G:L51 33.75598.5YesYes696
22B:B:T329 B:B:W339 14.56498.49NoYes089
23B:B:M45 B:B:W339 25.8183.49NoYes649
24B:B:M45 G:G:L50 27.14174.24NoNo649
25G:G:D48 G:G:L50 27.80325.43YesNo699
26G:G:D48 G:G:L51 29.78865.43YesYes696
27B:B:T221 G:G:E22 93.11075.64NoNo079
28B:B:K209 B:B:T221 46.72479.01YesNo467
29B:B:K209 B:B:W211 48.18966.96YesYes468
30B:B:F199 B:B:W211 96.17969.02YesYes498
31B:B:F199 B:B:L190 98.62227.31YesYes495
32B:B:L190 B:B:R150 98.76963.64YesYes456
33B:B:H62 B:B:R150 10013.54NoYes066
34B:B:H62 B:B:Y105 1003.27NoYes066
35B:B:L69 B:B:Y105 1007.03NoYes056
36B:B:D83 B:B:L69 1004.07NoNo085
37B:B:D83 B:B:R68 10015.48NoNo085
38B:B:R68 B:B:Y85 10027.78NoNo054
39B:B:C218 B:B:T221 46.71463.38YesNo457
40B:B:C218 B:B:W211 47.69475.22YesYes458
41B:B:Y85 G:G:F61 1008.25NoYes048
42B:B:I338 G:G:F61 59.47315.02YesYes058
43B:B:S84 G:G:F61 59.446.61NoYes058
44B:B:S84 B:B:W63 59.51784.94NoYes057
45B:B:I338 B:B:W63 59.59973.52YesYes057
46B:B:K57 B:B:Q75 50.702610.85YesYes199
47B:B:K57 B:B:W332 10018.57YesYes199
48B:B:S316 B:B:W332 1004.94NoYes099
49B:B:C317 B:B:S316 1003.44NoNo079
50B:B:C317 B:B:M61 1004.86NoYes076
51B:B:M61 B:B:W63 1006.98YesYes767
52B:B:K57 B:B:Y59 50.61899.55YesNo198
53B:B:W99 B:B:Y59 50.64255.79YesNo198
54B:B:Q75 B:B:W99 50.74099.86YesYes199
55B:B:L117 B:B:W99 50.65966.83YesYes199
56A:A:F238 B:B:W99 50.659515.03YesYes199
57A:A:W234 B:B:L117 50.65113.42YesYes199
58A:A:F238 A:A:W234 50.83174.01YesYes199
59B:B:R314 B:B:W332 25.435333.99YesYes189
60A:A:W281 B:B:R314 25.30954YesYes158
61A:A:N279 A:A:W281 25.47143.39NoYes185
62A:A:I235 A:A:N279 25.44117.08NoNo198
63A:A:I235 A:A:W234 25.49783.52NoYes199
64A:A:H387 A:A:I383 95.52246.63YesYes388
65A:A:H41 A:A:I383 95.84673.98YesYes368
66A:A:F219 A:A:H41 96.60067.92YesYes086
67A:A:F219 A:A:L43 99.17556.09YesNo087
68A:A:I245 A:A:L43 1005.71NoNo077
69A:A:I245 A:A:I375 1004.42NoNo079
70A:A:F290 A:A:I375 1005.02YesNo099
71A:A:F290 A:A:V247 1003.93YesNo097
72A:A:N292 A:A:V247 1004.43YesNo097
73A:A:K293 A:A:N292 1008.39YesYes2099
74A:A:D249 A:A:K293 59.778215.21NoYes089
75A:A:D249 A:A:S251 60.2295.89NoNo089
76A:A:K300 A:A:S251 1004.59NoNo099
77A:A:K300 A:A:Y253 1008.36NoYes098
78A:A:I308 A:A:Y253 10012.09NoYes078
79A:A:F312 A:A:I308 1005.02YesNo087
80A:A:F312 A:A:Q267 1004.68YesNo084
81A:A:L270 A:A:Q267 1003.99NoNo064
82A:A:F345 A:A:L270 10010.96YesNo086
83A:A:F273 A:A:F345 61.87029.65YesYes298
84A:A:F246 A:A:F273 62.5856.43NoYes299
85A:A:D272 A:A:F246 1007.17NoNo089
86A:A:D272 A:A:R232 10011.91NoYes088
87A:A:R232 A:A:W234 1006YesYes189
88A:A:K293 A:A:L296 59.76324.23YesNo096
89A:A:L296 A:A:S251 60.79286.01NoNo069
90A:A:F345 A:A:L289 61.88698.53YesYes289
91A:A:F246 A:A:L289 63.93843.65NoYes299
92A:A:D378 A:A:Y360 14.313116.09NoYes078
93A:A:H387 A:A:Y391 88.9256.53YesYes384
94A:A:Y391 R:R:L60 81.96758.21YesYes347
95R:R:L60 R:R:L64 15.08015.54YesYes378
96R:R:L60 R:R:R123 52.97414.86YesYes379
97R:R:R123 R:R:Y209 39.28588.23YesYes399
98R:R:I238 R:R:Y209 36.31327.25YesYes079
99R:R:I238 R:R:W202 35.74833.52YesYes076
100R:R:F198 R:R:W202 34.81178.02NoYes086
101R:R:F198 R:R:H249 34.435510.18NoYes088
102R:R:H249 R:R:Y248 11.37987.62YesYes087
103R:R:L64 R:R:Y294 13.59323.52YesYes389
104R:R:L116 R:R:Y294 36.23225.86NoYes089
105R:R:L116 R:R:L67 35.66785.54NoNo089
106R:R:D290 R:R:L67 21.51689.5NoNo2299
107R:R:D290 R:R:N286 20.990713.46NoNo099
108R:R:F245 R:R:N286 19.861513.29YesNo089
109R:R:F245 R:R:I109 20.41426.28YesYes087
110R:R:I109 R:R:Y74 23.62333.63YesYes076
111R:R:L78 R:R:Y74 11.3424.69NoYes076
112R:R:I119 R:R:L60 13.75914.28YesYes397
113R:R:I119 R:R:Y294 13.60648.46YesYes399
114R:R:R123 R:R:Y294 13.5918.23YesYes399
115R:R:H249 R:R:Y110 15.152215.24YesYes087
116R:R:D71 R:R:L67 13.58665.43YesNo2299
117R:R:D71 R:R:N43 10.21915.39YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9J31
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Danio Rerio
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.05
Date 2025-01-22
D.O.I. doi.org/10.1038/s41467-025-55901-2
Net Summary
Imin 3.27
Number of Linked Nodes 860
Number of Links 1037
Number of Hubs 170
Number of Links mediated by Hubs 625
Number of Communities 23
Number of Nodes involved in Communities 238
Number of Links involved in Communities 340
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 21946535
Length Of Smallest Path 3
Average Path Length 83.8103
Length of Longest Path 99
Minimum Path Strength 1.275
Average Path Strength 8.0829
Maximum Path Strength 26.28
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 33.1375
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.5292
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • response to pH   • response to abiotic stimulus   • response to acidic pH   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9J31_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9J31_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIHSGIF 
ETKFQVDKV NFHMFDVGG QRDERRKWI QCFNDVTAI IFVVSSYNR 
LQEALNFKS IWNNRWLRT ISVILFLNK QDLLAEKVL AGKSKIEDY 
FPEFARYTT PEDATPEPG EDPRVTRAK YFIRDEFLR ISTASGDGR 
HYCYPHFTC AVDTENRRF NDCRDIIQR MHLRQYELL DVSADAARS 
MDNYGGDDA I


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtE7FEL0
Sequence
>9J31_Chain_R
CNVDSNIDQ FFQPTLYII VIVLGFPTN CMALWAAYM QVKQKNELG 
IYLMNLSIA DLLYITTLP LWIDYFVHH VSCKLFGFI FYTNIYVSI 
AFLCCISVD RYLAVAHPL KFAKVRRVK TALLVSAIV WLTEIVANS 
APLFHCFEK YPMEPWVAG MNLYRTFLG FLAPWGIML AAYRGILRA 
VRGNVSTER QEKAKIKRL ALSLILIVL LCFAPYHVL LLWRSVLFL 
INPCDCGGE ENLFGAYHV TLALTSLNC VADPILYCF VNEGARHDV 
GRALATLLG L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9J31_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-2610.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-2610.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-2610.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-2610.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-2610.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-2610.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-2610.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-2610.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-2610.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-2610.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-2610.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-2610.1016/j.cell.2024.12.001
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-2610.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-2610.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-2610.1016/j.cell.2024.12.001
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZFJAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.12024-08-07To be published
8ZFJ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.12024-08-07To be published
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-2610.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-2610.1016/j.cell.2024.12.001




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