Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:V11 9.73413
2R:R:D16 4.71515
3R:R:P20 8.535405
4R:R:Y24 6.85333619
5R:R:I28 5.82417
6R:R:V30 4.6225446
7R:R:E51 8.1075427
8R:R:V54 3.2825407
9R:R:Y55 7.416527
10R:R:D63 7.265409
11R:R:Y66 7.26517
12R:R:L70 8.022518
13R:R:W73 10.274517
14R:R:Y76 6.25833616
15R:R:F77 8.552515
16R:R:D81 5.4975414
17R:R:W83 7.29875819
18R:R:F93 8.7525416
19R:R:F97 9.484517
20R:R:Y102 7.016507
21R:R:I103 5.4375407
22R:R:F107 8.915458
23R:R:L108 6.8725408
24R:R:I111 5.0525429
25R:R:Y116 5.158508
26R:R:F125 4.7125406
27R:R:L158 5.6025405
28R:R:H165 5.80667611
29R:R:F167 9.2475414
30R:R:E170 10.0025414
31R:R:F172 7.19667615
32R:R:M174 7.8325401
33R:R:W177 15.685401
34R:R:N182 6.18405
35R:R:F190 8.5775438
36R:R:W194 5.856506
37R:R:Y201 6.285608
38R:R:L229 6.87408
39R:R:F237 6.61538
40R:R:Y240 10.282536
41R:R:H241 7.12333638
42R:R:R247 9.058514
43R:R:F260 7.585401
44R:R:V264 4.82404
45R:R:F265 11.8275414
46R:R:H269 8.872515
47R:R:V280 4.7575448
48R:R:Y286 6.606529
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D161 R:R:H165 24.411.26NoYes021
2R:R:D161 R:R:Y163 20.93866.9NoNo023
3R:R:H10 R:R:Y163 13.979714.16NoNo033
4R:R:D81 R:R:H165 17.24395.04YesYes141
5R:R:R247 R:R:Y268 21.04099.26YesNo045
6R:R:H269 R:R:Y268 30.7937.62YesNo055
7R:R:W83 R:R:Y76 14.65784.82YesYes196
8R:R:C90 R:R:W83 18.11316.53NoYes199
9R:R:C90 R:R:L158 25.83894.76NoYes095
10R:R:L158 R:R:R160 14.17359.72YesNo051
11R:R:R160 R:R:T166 11.824214.23NoNo013
12R:R:F19 R:R:P20 20.2125.78NoYes055
13R:R:F77 R:R:P20 15.860718.78YesYes055
14R:R:F77 R:R:H269 14.27849.05YesYes155
15R:R:F19 R:R:L23 15.19079.74NoNo055
16R:R:A273 R:R:P20 10.29043.74NoYes055
17R:R:A273 R:R:Y24 12.40554NoYes059
18R:R:F77 R:R:Y24 26.07844.13YesYes159
19R:R:W73 R:R:Y76 11.01967.72YesYes176
20R:R:F97 R:R:W73 37.270320.04YesYes177
21R:R:L70 R:R:Y24 14.065816.41YesYes189
22R:R:S276 R:R:Y24 12.85227.63NoYes079
23R:R:P283 R:R:T34 11.90235.25NoNo097
24R:R:N35 R:R:P283 13.36629.77NoNo099
25R:R:D63 R:R:N35 17.72566.73YesNo099
26R:R:C279 R:R:D63 75.923712.45NoYes099
27R:R:C279 R:R:Y66 72.90445.38NoYes097
28R:R:F97 R:R:Y66 46.026710.32YesYes177
29R:R:D282 R:R:D63 77.16693.99NoYes099
30R:R:D282 R:R:N278 31.877512.12NoNo099
31R:R:F237 R:R:N278 32.125114.5YesNo089
32R:R:F237 R:R:H241 18.06733.39YesYes388
33R:R:H241 R:R:Y240 44.21845.44YesYes386
34R:R:Y240 R:R:Y268 46.648412.91YesNo065
35R:R:A38 R:R:S60 10.50563.42NoNo098
36R:R:L39 R:R:S60 11.81353NoNo078
37R:R:L39 R:R:M57 14.4134.24NoNo075
38R:R:A42 R:R:M57 24.46383.22NoNo075
39R:R:A42 R:R:L56 25.71243.15NoNo078
40R:R:L56 R:R:Y286 31.09983.52NoYes089
41R:R:L108 R:R:Y286 90.57618.21YesYes089
42R:R:D282 R:R:L108 1009.5NoYes098
43R:R:I111 R:R:Y55 59.35523.63YesYes297
44R:R:I111 R:R:R115 16.32366.26YesNo299
45R:R:R115 R:R:Y201 27.73348.23NoYes098
46R:R:I230 R:R:Y201 38.72344.84NoYes078
47R:R:I230 R:R:W194 38.87414.7NoYes076
48R:R:F190 R:R:W194 40.48876.01YesYes086
49R:R:F190 R:R:H241 40.087714.71YesYes388
50R:R:I111 R:R:Y286 48.90616.04YesYes299
51R:R:A134 R:R:Y55 52.35335.34NoYes287
52R:R:A134 R:R:V54 51.87435.09NoYes087
53R:R:S138 R:R:V54 52.29143.23NoYes077
54R:R:F107 R:R:S138 26.845.28YesNo587
55R:R:N58 R:R:S138 24.278110.43NoNo597
56R:R:N58 R:R:W142 23.04576.78NoNo599
57R:R:F107 R:R:W142 23.14259.02YesNo589
58R:R:I103 R:R:W142 43.664112.92YesNo079
59R:R:C168 R:R:W73 11.10843.92NoYes197
60R:R:I103 R:R:L146 30.94912.85YesNo073
61R:R:F95 R:R:L146 28.393.65NoNo063
62R:R:F95 R:R:L153 13.03527.31NoNo064
63R:R:L272 R:R:Y240 10.123514.07NoYes056
64R:R:F95 R:R:T99 12.922114.27NoNo065
65R:R:H241 R:R:Y102 14.979.8YesYes087
66R:R:I204 R:R:Y201 49.55462.42NoYes088
67R:R:I204 R:R:Y116 30.41633.63NoYes088
68R:R:H121 R:R:Y116 12.03418.71NoYes068
69R:R:F125 R:R:H121 10.33074.53YesNo066
70R:R:I204 R:R:V119 18.62174.61NoNo088
71R:R:N149 R:R:T99 10.32532.92NoNo075
72R:R:L229 R:R:Y201 14.13049.38YesYes088
73R:R:G203 R:R:Y116 10.33072.9NoYes048
74R:R:V119 R:R:V208 16.93441.6NoNo088
75R:R:K219 R:R:V208 13.64061.52NoNo068
76R:R:K219 R:R:T214 12.03413NoNo063
77R:R:L23 R:R:L277 12.67192.77NoNo055
78R:R:F274 R:R:L277 10.14774.87NoNo075
79R:R:F260 R:R:R247 11.23493.21YesYes014
80R:R:E262 R:R:H10 10.49221.23NoNo033
81R:R:D81 R:R:F77 13.43073.58YesYes145
82R:R:F97 R:R:Y24 14.30265.16YesYes179
83R:R:L70 R:R:Y66 13.42818.21YesYes187
84R:R:S276 R:R:Y66 13.07028.9NoYes077
85R:R:F97 R:R:Y98 12.30058.25YesNo075
86R:R:F172 R:R:R247 12.3844.28YesYes154
87R:R:R115 R:R:Y286 11.66288.23NoYes299
88R:R:L229 R:R:Y286 15.64547.03YesYes089
89R:R:W73 R:R:W83 17.62614.06YesYes179
90R:R:C168 R:R:C90 10.04017.28NoNo199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z9P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.23
Number of Linked Nodes 286
Number of Links 332
Number of Hubs 48
Number of Links mediated by Hubs 172
Number of Communities 6
Number of Nodes involved in Communities 59
Number of Links involved in Communities 88
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 85686
Length Of Smallest Path 3
Average Path Length 14.5639
Length of Longest Path 31
Minimum Path Strength 1.5
Average Path Strength 6.90591
Maximum Path Strength 22.955
Minimum Path Correlation 0.7
Average Path Correlation 0.941647
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 53.6673
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.2394
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP46093
Sequence
>8Z9P_nogp_Chain_R
GCHVDSRVD HLFPPSLYI FVIGVGLPT NCLALWAAY RQVQQRNEL 
GVYLMNLSI ADLLYICTL PLWVDYFLH HDNWIHGPG SCKLFGFIF 
YTNIYISIA FLCCISVDR YLAVAHPLR FARLRRVKT AVAVSSVVW 
ATELGANSA PLFHDELFR DRYNHTFCF EKFPMEGWV AWMNLYRVF 
VGFLFPWAL MLLSYRGIL RAVRGSVST ERQEKAKIK RLALSLIAI 
VLVCFAPYH VLLLSRSAI YLGRPWDCG FEERVFSAY HSSLAFTSL 
NCVADPILY CLVNEGARS DVAKALHNL LRFLAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z9P_nogp.zip



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