Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 3.875409
2A:A:H41 7.67426
3A:A:K53 5.36409
4A:A:F219 7.465608
5A:A:Q227 5.8225419
6A:A:K233 5.72167619
7A:A:W234 6.772519
8A:A:C237 6.375418
9A:A:F238 11.9625419
10A:A:Y253 8.0125208
11A:A:F273 4.96754199
12A:A:W277 8.5265196
13A:A:W281 14.3125415
14A:A:F290 7.3865149
15A:A:N292 6.87254139
16A:A:Q294 6.315476
17A:A:F312 3.7575408
18A:A:F315 13.895406
19A:A:Y318 7.725406
20A:A:E330 6.17573
21A:A:V334 3.465404
22A:A:Y339 8.425473
23A:A:F340 12.6875407
24A:A:R342 6.504574
25A:A:F345 7.5075408
26A:A:S349 4.45407
27A:A:Y360 9.936588
28A:A:F363 9.6975475
29A:A:S366 4.2654139
30A:A:N371 5.77254149
31A:A:R373 7.395425
32A:A:R374 8.364144
33A:A:F376 5.91833628
34A:A:D381 4.3775488
35A:A:I383 5.5625428
36A:A:R385 5.836585
37A:A:H387 5.718528
38A:A:Y391 8.44167624
39A:A:L394 5.358588
40B:B:I37 3.48402
41B:B:V40 3.9356113
42B:B:H54 9.882549
43B:B:K57 11.888519
44B:B:Y59 9.19518
45B:B:M61 4.535446
46B:B:W63 7.438547
47B:B:L70 5.23445
48B:B:V71 4.416598
49B:B:Q75 12.1225419
50B:B:D76 5.8245169
51B:B:K78 5.405408
52B:B:L79 4.164597
53B:B:I80 8.468548
54B:B:I81 5.6375497
55B:B:W82 10.38649
56B:B:Y85 12.0475444
57B:B:K89 6.662549
58B:B:H91 6.1025405
59B:B:L95 5.0525498
60B:B:W99 11.836519
61B:B:M101 5.6775419
62B:B:C103 3.0025498
63B:B:Y105 4.985696
64B:B:Y111 9.705404
65B:B:V112 4.7575498
66B:B:C114 3.5725498
67B:B:L117 5.5225419
68B:B:N119 5.2925419
69B:B:Y124 5.615696
70B:B:H142 8.01519
71B:B:Y145 8.678518
72B:B:F151 5.232509
73B:B:L152 4.3025403
74B:B:I157 5.95417
75B:B:T159 4.95167619
76B:B:D163 9.48419
77B:B:W169 9.31833618
78B:B:F180 7.6045107
79B:B:H183 9.9665109
80B:B:V200 7.6275466
81B:B:C204 6.3175417
82B:B:D205 5.644109
83B:B:K209 12.51754106
84B:B:L210 4.5375405
85B:B:W211 8.721676108
86B:B:Q220 4.7625407
87B:B:H225 9.98167669
88B:B:D228 8.718519
89B:B:I232 5.79468
90B:B:F235 9.6185126
91B:B:P236 6.0154127
92B:B:N237 7.5175405
93B:B:F241 6.598566
94B:B:D246 6.1625419
95B:B:D247 7.89469
96B:B:R251 8.662568
97B:B:F253 6.48333666
98B:B:D254 4.3675409
99B:B:R256 5.4375409
100B:B:Q259 3.7675406
101B:B:M262 6.82404
102B:B:Y264 6.312505
103B:B:F278 6.607147127
104B:B:R283 5.328577119
105B:B:Y289 6.5717
106B:B:D290 7.236516
107B:B:C294 4.9275455
108B:B:V296 3.1425405
109B:B:W297 6.34418
110B:B:K301 4.57405
111B:B:H311 9.908559
112B:B:R314 14.242518
113B:B:V315 4.4275457
114B:B:T329 5.3825458
115B:B:W332 13.0667619
116B:B:D333 7.45459
117B:B:W339 8.23833659
118G:G:L19 4.4625409
119G:G:D48 4.944559
120G:G:F61 5.21286748
121R:R:V11 7.035433
122R:R:P20 6.4925405
123R:R:Y24 5.085609
124R:R:I28 4.975407
125R:R:R44 6.915404
126R:R:L52 5.0025408
127R:R:V54 2.875427
128R:R:Y55 5.24667627
129R:R:L56 4.8875408
130R:R:D63 6.6775409
131R:R:Y66 7.82833607
132R:R:W73 8.96437
133R:R:Y76 8.62667636
134R:R:F77 7.835405
135R:R:W83 8.73667639
136R:R:F97 10.458537
137R:R:Y98 6.8925435
138R:R:Y102 8.57407
139R:R:F107 104158
140R:R:I111 4.44429
141R:R:R115 7.4675429
142R:R:H121 7.5025426
143R:R:L123 4.4526
144R:R:F125 7.265426
145R:R:V131 2.5075423
146R:R:W142 8.02254159
147R:R:E145 5.9425407
148R:R:P152 5.3025433
149R:R:E157 8.765435
150R:R:D161 7.3575432
151R:R:Y163 13.076533
152R:R:H165 9.99531
153R:R:F167 9.47333634
154R:R:F169 9.71434
155R:R:F172 6.00167635
156R:R:W177 10.1017631
157R:R:R185 6.395405
158R:R:W194 6.0725426
159R:R:Y201 5.775628
160R:R:S213 5.31483
161R:R:E218 7485
162R:R:F237 8.82438
163R:R:Y240 7.505636
164R:R:H241 8.482538
165R:R:R247 9.91667634
166R:R:F260 6.22833631
167R:R:F265 10.415434
168R:R:Y268 11.34435
169R:R:H269 5.762535
170R:R:D282 8.09429
171R:R:Y286 7.154529
172R:R:C287 2.9975407
173W:W:?1 5.78556920
174W:W:?2 10.2712820
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Q75 B:B:W99 55.66015.48YesYes199
2B:B:K57 B:B:Q75 27.687313.56YesYes199
3B:B:K57 B:B:W332 27.504223.21YesYes199
4B:B:S316 B:B:W332 43.78884.94NoYes099
5B:B:I58 B:B:S316 17.44993.1NoNo099
6B:B:H54 B:B:I58 16.252410.61YesNo099
7B:B:Q75 B:B:Y59 27.757420.29YesYes198
8B:B:W332 B:B:Y59 59.33975.79YesYes198
9A:A:F212 A:A:F219 47.440612.86NoYes098
10A:A:F212 A:A:M60 47.62563.73NoNo099
11A:A:M60 A:A:Q59 47.81426.8NoNo099
12A:A:N371 A:A:Q59 47.90863.96YesNo099
13A:A:N371 A:A:R374 48.34756.03YesYes1494
14A:A:E370 A:A:R374 94.74584.65NoYes044
15A:A:D368 A:A:E370 95.029911.69NoNo094
16A:A:C365 A:A:D368 95.10044.67NoNo089
17A:A:C365 A:A:Q294 95.24053.05NoYes086
18A:A:F363 A:A:Q294 93.49217.03YesYes756
19A:A:F363 A:A:R342 95.35384.28YesYes754
20A:A:L346 A:A:R342 95.06446.07NoYes744
21A:A:L346 A:A:S349 95.26454.5NoYes047
22A:A:S349 A:A:W277 94.40354.94YesYes076
23A:A:V287 A:A:W277 94.27344.9NoYes1966
24A:A:I244 A:A:V287 1006.14NoNo086
25A:A:I244 A:A:L44 99.89945.71NoNo089
26A:A:F238 A:A:L44 82.409421.92YesNo099
27A:A:F238 B:B:W99 55.246617.04YesYes199
28A:A:F238 B:B:L117 27.50873.65YesYes199
29A:A:C237 B:B:L117 27.86124.76YesYes189
30A:A:C237 B:B:Y59 27.12016.72YesYes188
31A:A:F219 A:A:H41 43.52227.92YesYes086
32A:A:H41 A:A:I383 42.94457.95YesYes268
33A:A:L44 A:A:L46 18.01328.3NoNo098
34A:A:W234 B:B:Y145 16.96466.75YesYes198
35A:A:R231 A:A:W234 17.38837NoYes099
36A:A:L46 A:A:R231 17.47224.86NoNo089
37B:B:R314 B:B:W332 48.322222.99YesYes189
38B:B:D290 B:B:R314 48.620916.68YesYes168
39A:A:H362 A:A:R374 45.692212.41NoYes094
40A:A:D378 A:A:H362 45.10095.04NoNo079
41A:A:D378 A:A:Y360 45.074218.39NoYes078
42A:A:R385 R:R:S213 42.99597.91YesYes853
43A:A:Y360 R:R:S213 42.90073.82YesYes883
44A:A:H387 A:A:I383 43.18566.63YesYes288
45A:A:L394 A:A:R385 42.21573.64YesYes885
46A:A:H387 A:A:Y391 43.33794.36YesYes284
47A:A:L394 R:R:N290 41.54944.12YesNo088
48A:A:E392 R:R:N290 41.46026.57NoNo068
49A:A:E392 R:R:L56 41.0853.98NoYes068
50A:A:Y391 R:R:D114 42.014613.79YesNo248
51R:R:L56 R:R:Y286 40.06333.52YesYes089
52B:B:C149 B:B:T159 16.71593.38NoYes089
53B:B:C149 B:B:T102 16.49565.07NoNo088
54B:B:C148 B:B:T102 16.27513.38NoNo068
55B:B:C148 B:B:L190 16.05446.35NoNo065
56B:B:L190 B:B:S160 15.83344.5NoNo056
57B:B:S160 B:B:V187 15.39074.85NoNo069
58B:B:A203 B:B:V187 15.1695.09NoNo089
59B:B:A203 B:B:H183 13.56738.78NoYes1089
60B:B:C271 B:B:D290 56.06753.11NoYes156
61B:B:C271 B:B:Y289 54.17944.03NoYes157
62B:B:W297 B:B:Y289 50.14727.72YesYes187
63B:B:W297 B:B:Y264 48.71663.86YesYes085
64B:B:L252 B:B:Y264 20.24067.03NoYes075
65B:B:L252 B:B:L261 19.84985.54NoNo075
66B:B:L261 G:G:V30 19.45884.47NoNo058
67B:B:Q259 G:G:V30 19.06754.3YesNo068
68B:B:Q259 B:B:R22 17.48994.67YesNo066
69B:B:D258 B:B:R22 15.132614.29NoNo076
70B:B:M262 B:B:Y264 17.463410.78YesYes045
71B:B:L30 B:B:M262 14.01367.07NoYes054
72B:B:L30 B:B:T34 13.62954.42NoNo055
73B:B:L300 B:B:T34 12.47635.9NoNo065
74B:B:L300 B:B:R283 11.69888.5NoYes1169
75B:B:T321 B:B:W63 15.246112.13NoYes477
76B:B:D323 B:B:T321 14.25697.23NoNo477
77B:B:D323 B:B:M325 13.94889.7NoNo075
78B:B:M325 G:G:P49 13.62466.71NoNo057
79G:G:D48 G:G:P49 12.97814.83YesNo097
80G:G:D48 G:G:L50 11.40515.43YesNo599
81B:B:M45 G:G:L50 11.12135.65NoNo549
82B:B:S84 B:B:W63 10.4294.94NoYes457
83B:B:C317 B:B:M61 25.50324.86NoYes076
84B:B:H142 B:B:T159 22.92845.48YesYes199
85B:B:H142 B:B:S161 29.650313.95YesNo199
86B:B:G162 B:B:Y145 20.39054.35NoYes198
87B:B:G162 B:B:S161 30.85373.71NoNo199
88B:B:D258 B:B:Q220 14.74727.83NoYes077
89B:B:L285 B:B:Y264 12.77375.86NoYes065
90B:B:F278 B:B:L285 11.978913.4YesNo1276
91R:R:L108 R:R:Y286 35.01110.55NoYes289
92R:R:D282 R:R:L108 34.67489.5YesNo298
93R:R:D282 R:R:D63 24.88446.65YesYes099
94R:R:C279 R:R:D63 21.34136.22NoYes099
95R:R:C279 R:R:Y66 20.05145.38NoYes097
96R:R:F97 R:R:Y66 11.1129.28YesYes077
97R:R:W73 R:R:Y76 19.14137.72YesYes376
98R:R:D114 R:R:Y55 40.64974.6NoYes287
99R:R:Y55 W:W:?1 40.97673.74YesYes270
100R:R:E145 W:W:?1 25.8515.63YesYes070
101R:R:E145 R:R:Y102 23.09873.37YesYes077
102R:R:R185 R:R:Y102 12.204211.32YesYes057
103R:R:R185 R:R:Y98 23.03145.14YesYes055
104R:R:W73 R:R:Y98 13.49033.86YesYes375
105R:R:V188 W:W:?1 12.56523.17NoYes040
106R:R:V188 R:R:Y184 12.250512.62NoNo043
107R:R:R185 R:R:Y184 11.96323.09YesNo053
108R:R:H241 R:R:Y240 15.60623.27YesYes386
109R:R:Y240 R:R:Y268 12.37515.96YesYes365
110B:B:C204 B:B:D186 12.04663.11YesNo179
111B:B:D186 B:B:G162 10.64796.71NoNo199
112B:B:C317 B:B:S316 26.0973.44NoNo079
113B:B:M61 B:B:W63 23.71075.82YesYes467
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V137 R:R:Y55 6.31 2 No Yes 5 7 2 2
R:R:Y55 W:W:?1 3.74 2 Yes Yes 7 0 2 1
R:R:C109 R:R:L196 3.17 0 No No 8 6 2 1
R:R:C110 W:W:?1 6.74 0 No Yes 7 0 2 1
R:R:S112 R:R:S200 6.52 2 No No 9 8 2 1
R:R:S200 R:R:V113 3.23 2 No No 8 6 1 1
R:R:V113 W:W:?1 9.5 2 No Yes 6 0 1 1
R:R:V113 W:W:?2 6.33 2 No Yes 6 0 1 0
R:R:A120 R:R:Y116 5.34 2 No No 7 8 2 1
R:R:H121 R:R:Y116 9.8 2 Yes No 6 8 2 1
R:R:Y116 W:W:?2 27.4 2 No Yes 8 0 1 0
R:R:L117 W:W:?1 4.41 0 No Yes 6 0 2 1
R:R:A120 R:R:H121 4.39 2 No Yes 7 6 2 2
R:R:V137 W:W:?1 9.5 2 No Yes 5 0 2 1
R:R:E145 W:W:?1 5.63 0 Yes Yes 7 0 2 1
R:R:V188 W:W:?1 3.17 0 No Yes 4 0 2 1
R:R:F192 R:R:L196 6.09 0 No No 5 6 2 1
R:R:L196 W:W:?2 5.88 0 No Yes 6 0 1 0
R:R:L199 W:W:?2 11.76 0 No Yes 5 0 1 0
R:R:S200 W:W:?2 7.98 2 No Yes 8 0 1 0
R:R:R202 R:R:R206 4.26 0 No No 3 3 1 2
R:R:R202 W:W:?2 7.74 0 No Yes 3 0 1 0
R:R:G203 W:W:?2 7.27 0 No Yes 4 0 1 0
W:W:?1 W:W:?2 7.81 2 Yes Yes 0 0 1 0
R:R:T144 W:W:?1 1.57 0 No Yes 5 0 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
66.67Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
62.50Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
26.67Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
15.38Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
14.29Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.11Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
11.11Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
9.09Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
9.09Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
8.33Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
8.33Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
7.69Single7EB2rac-BHFF7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.14Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
6.67Single8K9LBMS-9861228K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
6.67Single9CM3Compound 1879CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9K1CDHA9K1C-FFA1-DHA-Gi1/β1/γ2
6.25Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
6.25Single7C7QBHFF7C7Q-GABAB1, GABAB2-Baclofen-BHFF
6.25Single7EJX(1R;2R)-2-PCCA7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
6.25Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
6.25Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
6.25Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
6.25Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
5.88Single5O9HNDT95137275O9H-C5a1-NDT9513727
5.88Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
5.26Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
5.00Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/β1/γ2
5.00Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
4.76Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E51 R:R:Y55 7.86 2 No Yes 7 7 2 1
R:R:D114 R:R:E51 14.29 2 No No 8 7 2 2
R:R:A134 R:R:E51 4.53 2 No No 8 7 2 2
R:R:I111 R:R:Y55 3.63 2 Yes Yes 9 7 2 1
R:R:D114 R:R:Y55 4.6 2 No Yes 8 7 2 1
R:R:A134 R:R:Y55 5.34 2 No Yes 8 7 2 1
R:R:V137 R:R:Y55 6.31 2 No Yes 5 7 1 1
R:R:Y55 W:W:?1 3.74 2 Yes Yes 7 0 1 0
R:R:E145 R:R:Y102 3.37 0 Yes Yes 7 7 1 2
R:R:E145 R:R:I103 8.2 0 Yes No 7 7 1 2
R:R:C110 W:W:?1 6.74 0 No Yes 7 0 1 0
R:R:S200 R:R:V113 3.23 2 No No 8 6 2 1
R:R:V113 W:W:?1 9.5 2 No Yes 6 0 1 0
R:R:V113 W:W:?2 6.33 2 No Yes 6 0 1 1
R:R:Y116 W:W:?2 27.4 2 No Yes 8 0 2 1
R:R:F125 R:R:L117 3.65 2 Yes No 6 6 2 1
R:R:L117 W:W:?1 4.41 0 No Yes 6 0 1 0
R:R:V137 W:W:?1 9.5 2 No Yes 5 0 1 0
R:R:E145 R:R:N149 6.57 0 Yes No 7 7 1 2
R:R:E145 W:W:?1 5.63 0 Yes Yes 7 0 1 0
R:R:V188 R:R:Y184 12.62 0 No No 4 3 1 2
R:R:G189 R:R:V188 3.68 0 No No 6 4 2 1
R:R:V188 W:W:?1 3.17 0 No Yes 4 0 1 0
R:R:L196 W:W:?2 5.88 0 No Yes 6 0 2 1
R:R:L199 W:W:?2 11.76 0 No Yes 5 0 2 1
R:R:S200 W:W:?2 7.98 2 No Yes 8 0 2 1
R:R:R202 W:W:?2 7.74 0 No Yes 3 0 2 1
R:R:G203 W:W:?2 7.27 0 No Yes 4 0 2 1
W:W:?1 W:W:?2 7.81 2 Yes Yes 0 0 0 1
R:R:T133 R:R:V137 1.59 0 No No 3 5 2 1
R:R:T144 R:R:V140 1.59 0 No No 5 3 1 2
R:R:T144 W:W:?1 1.57 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
50.00Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
31.58Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
30.77Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
28.57Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
28.57Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
27.27Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
26.67Single5O9HNDT95137275O9H-C5a1-NDT9513727
26.67Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
23.53Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
23.53Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
22.22Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/β1/γ2
21.43Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.43Single8K9LBMS-9861228K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
21.43Single9CM3Compound 1879CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single9K1CDHA9K1C-FFA1-DHA-Gi1/β1/γ2
18.75Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
17.65Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
16.67Single8YYXLeukotriene e48YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
15.79Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.38Single9NS9Compound 1879NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
14.29Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
14.29Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
14.29Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
13.64Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
13.33Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
12.50Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
12.50Single7LJCMevidalen7LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
11.76Single8IYXYL-3658IYX-GPR34-YL-365
11.11Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.53Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
10.34Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.00Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
7.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
6.67Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
6.25Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.25Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.25Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
6.25Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
5.88Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
5.88Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.88Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
5.88Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
5.88Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.56Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
5.26Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.26Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
4.76Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.76Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
4.76Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.76Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
4.76Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
4.76Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.76Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.76Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.55Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.55Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
4.55Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
4.55Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.55Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.35Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.35Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
4.35Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
4.35Single8XVJMacitentan8XVJ-ETA-Macitentan
4.35Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.35Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
4.17Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.17Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
4.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
3.85Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
3.45Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
3.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
3.12Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone

PDB Summary
PDB 9JCO
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo sapiens
Ligand -
Other Ligand(s) LPC
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.36
Date 2025-07-09
D.O.I. doi.org/10.1038/s41421-025-00807-y
Net Summary
Imin 3.05
Number of Linked Nodes 883
Number of Links 1084
Number of Hubs 174
Number of Links mediated by Hubs 630
Number of Communities 23
Number of Nodes involved in Communities 261
Number of Links involved in Communities 379
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 1267701
Length Of Smallest Path 3
Average Path Length 34.1725
Length of Longest Path 65
Minimum Path Strength 1.18
Average Path Strength 7.12741
Maximum Path Strength 24.865
Minimum Path Correlation 0.71
Average Path Correlation 0.984195
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.04082
Average % Of Corr. Nodes 44.1186
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.1534
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein-containing complex binding   • binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • intracellular anatomical structure   • cytoplasm   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • nephron development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • epithelium development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_W_
PDB ResiduesW:W:?1 W:W:?2
Environment DetailsOpen EMBL-EBI Page
Code_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9JCO_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRITSGIF 
ETKFQVDKV NFHMFDVGQ RDERRKWIQ CFNDVTAII FVVSSYNRL 
QEALNFKSI WNNRWLRTI SVILFLNKQ DLLAEKVLA GKSKIEDYF 
PEFARYTTP EDATPEPGE DPRVTRAKY FIRDEFLRI STASGDGRH 
YCYPHFTCV DTENRRFND CRDIIQRMH LRQYELLSA DAVRSMDNY 
KADDDSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JCO_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JCO_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JCO_Chain_R
EGCHVDSRV DHLFPPSLY IFVIGVGLP TNCLALWAA YRQVQQRNE 
LGVYLMNLS IADLLYICT LPLWVDYFL HHDNWIHGP GSCKLFGFI 
FYTNIYISI AFLCCISVD RYLAVAHPL RFARLRRVK TAVAVSSVV 
WATELGANS APLFHDELF RDRYNHTFC FEKFPMEGW VAWMNLYRV 
FVGFLFPWA LMLLSYRGI LRAVRGSVS TERQEKAKI KRLALSLIA 
IVLVCFAPY HVLLLSRSA IYLGRPWDC GFEERVFSA YHSSLAFTS 
LNCVADPIL YCLVNEGAR SDVAKALHN LLR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JCO.zip



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