Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 1.90251502
2G.S1.02 5.09155485
3G.S1.05 5.08926409
4G.S1.06 4.49975478
5G.H1.01 3.6884579
6G.S2.03 5.32906425
7G.S2.05 4.15997526
8G.S2.06 5.31293403
9G.S2.08 7.72244483
10G.s2s3.01 5.4936485
11G.S3.01 4.72693483
12G.S3.03 7.12171584
13G.S3.04 7.75434427
14G.S3.06 7.58359527
15G.S3.07 3.48865475
16G.s3h2.03 4.09026529
17G.H2.02 3.8004429
18G.H2.06 4.89604728
19G.H2.07 4.67462729
20G.h2s4.01 6.26207527
21G.S4.02 4.4367468
22G.S4.03 3.15804478
23G.S4.04 5.93265467
24G.s4h3.04 5.349446168
25G.s4h3.05 5.443564168
26G.H3.01 5.06241409
27G.H3.09 5.306769
28G.H3.13 3.56971468
29G.H3.17 7.17329504
30G.H3.18 5.98361465
31G.S5.02 3.44906467
32G.S5.03 2.79861476
33G.S5.04 3.78005568
34G.S5.05 3.72038779
35G.S5.07 3.68177578
36G.HG.04 5.14095506
37G.HG.15 3.80048405
38G.hgh4.02 5.605795206
39G.hgh4.05 5.93995506
40G.H4.03 6.57689405
41G.H4.05 3.688314224
42G.H4.10 8.706884203
43G.H4.15 4.71384565
44G.h4s6.01 3.84655404
45G.h4s6.11 3.65281463
46G.S6.02 4.691786215
47G.s6h5.01 4.93909474
48G.s6h5.05 1.67486408
49G.H5.03 5.33067474
50G.H5.08 5.713488
51G.H5.13 4.48425406
52G.H5.25 3.36312408
53G.H5.26 5.01786507
54b.1x4 1.73639408
55b.lhb1x3 2.52173402
56b.lhb1x6 4.151874123
57b.lhb1x11 3.72732494
58b.b1x3 4.033437
59b.b1x4 3.5231437
60b.b1x6 7.36159439
61b.l1x3 7.77004639
62b.b2x1 7.42863528
63b.b2x5 6.21695637
64b.b3x3 3.43024408
65b.l3x2 4.48285539
66b.b4x3 4.14734107
67b.b4x4 8.25687438
68b.b4x5 4.074054197
69b.b4x6 8.58351739
70b.l4x2 10.9534434
71b.b5x2 5.48106407
72b.b5x3 6.36551639
73b.b5x5 5.058164195
74b.b5x7 5.69718407
75b.l5x1 4.136085108
76b.l5x5 6.82087729
77b.b6x5 3.72226606
78b.l6x5 5.865954174
79b.b7x1 5.660685174
80b.l7x2 3.83813429
81b.l7x4 3.85006409
82b.b8x4 5.186915106
83b.l8x3 3.155574233
84b.l8x5 2.987534233
85b.b9x3 3.404835106
86b.l9x3 6.12882729
87b.l9x6 4.81706828
88b.b10x5 4.30514609
89b.l10x1 3.92199403
90b.b11x4 5.04244529
91b.l11x2 7.95971429
92b.b12x6 7.90777728
93b.b13x7 7.69635547
94b.l13x3 7.14869649
95b.l13x6 4.99749529
96b.l13x7 4.26717449
97b.b14x3 4.44294445
98b.b15x1 6.38001549
99b.b15x2 6.35934456
100b.b15x3 4.10405449
101b.l15x1 4.55598427
102b.l15x2 5.03495549
103b.b16x4 10.1488446
104b.b16x5 4.18675505
105b.b16x6 8.29958648
106b.b17x4 4.406064185
107b.b17x5 6.60237457
108b.b17x7 7.85084458
109b.l17x3 8.15666659
110b.b18x3 4.87402458
111b.l18x1 5.797827136
112b.l18x2 5.460084137
113b.b19x2 6.55324656
114b.b19x4 5.54183458
115b.l19x2 5.38926559
116b.b20x4 9.72668558
117b.b20x6 7.26024556
118b.b21x1 8.27262457
119b.b21x5 5.02963404
120b.b21x7 5.4379605
121b.l21x2 4.60029404
122b.b22x5 5.267725137
123b.l22x5 6.190766129
124b.b23x1 3.66751405
125b.b23x6 6.607756147
126b.l23x1 7.39074406
127b.b24x4 6.99684146
128b.b24x6 5.738554148
129b.l24x3 4.25839405
130b.b25x3 4.884164145
131b.l25x3 8.17264599
132b.l27x1 11.4888629
133b.l27x2 6.86541499
134b.b28x2 4.95054404
135b.b28x3 3.50183537
136b.b28x4 7.35436496
137b.b28x6 7.35961699
138g.h1x5 1.81731406
139g.l1x4 3.87536508
140g.h2x11 8.676824136
141g.ctx3 6.12172509
142g.ctx6 3.494896126
143g.ctx14 4.38908539
144g.ctx15 6.49297439
145g.ctx16 4.28652938
146Lig 6.29261410
1471x31 0.247214604
1481x50 5.30946509
1491x52 2.35118408
1501x60 3.78303407
151I1x50 6.121434158
1522x42 3.59917508
1532x46 4.75684419
1542x50 6.44519
1552x57 3.83502418
1562x60 3.89037517
157E1x50 6.223615259
1583x28 5.11094406
1593x37 3.40259508
1603x41 3.55612407
1613x42 5.62311418
1623x43 4.70258418
1633x49 5.358564119
1643x50 4.8981519
1653x51 6.97331409
1663x52 4.60187405
167I2x53 6.250425118
168I2x57 5.265244118
1694x50 4.96132419
170E2 6.307071414
1715x39 4.28377518
1725x47 7.04351618
1735x50 3.03402409
1745x58 4.58244619
1755x66 3.56207407
1766x44 4.04206619
1776x48 6.10224818
1786x49 3.35791407
1796x51 6.32331518
1806x52 6.52103517
181E3 4.13616514
1827x34 3.70133414
1837x38 6.77117417
1847x39 4.3414518
1857x42 6.23214718
1867x49 6.7065419
1877x52 2.67996418
1887x53 5.06765519
1898x47 3.70899409
1908x50 5.417157158
1918x54 3.495435158
192b.1x1 0.710148400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 17.20393.42307NoNo085
2b.b3x1 b.l2x3 17.02225.53408NoNo058
3b.b3x1 b.b6x5 16.98863.34996NoYes056
4b.b3x3 b.b6x5 15.02394.22911YesYes086
5b.b3x2 b.b4x6 15.34094.92371NoYes359
6b.b2x3 b.b3x2 15.48062.76162NoNo365
7b.b26x2 b.b2x3 29.68844.93446NoNo076
8b.b26x1 b.b26x2 29.99452.73148NoNo097
9b.b26x1 b.l27x1 30.30185.32345NoYes099
10b.b2x1 b.l27x1 83.32156.91038YesYes289
11b.b2x1 b.l3x1 84.366813.8128YesNo289
12b.l3x1 b.l5x5 84.83115.38013NoYes299
13G.H3.15 G.H3.17 22.07755.35531NoYes084
14G.H3.15 G.H3.18 22.13364.49416NoYes085
15G.H3.18 G.S4.02 22.23557.90678YesYes658
16G.S4.02 G.S5.02 25.80453.4235YesYes687
17G.H3.09 G.S5.02 25.16144.31759YesYes697
18G.S5.04 G.S5.06 24.25843.45049YesNo089
19G.S5.06 G.s4h3.01 25.35037.19416NoNo098
20G.HG.04 G.s4h3.01 24.96629.03025YesNo068
21G.HG.04 G.s4h3.04 26.81594.83562YesYes068
22G.HG.07 G.s4h3.04 62.26545.6924NoYes1658
23G.HG.07 G.s4h3.02 63.98223.31634NoNo057
24G.s4h3.02 G.s5hg.01 64.11473.53484NoNo079
25G.S5.07 G.s5hg.01 64.8632.97604YesNo089
26G.H1.04 G.S5.07 31.34383.5403NoYes798
27G.H1.04 G.S5.05 31.48113.51544NoYes799
28G.S4.03 G.S5.05 17.29672.76315YesYes789
29G.S1.04 G.S4.03 11.70414.09192NoYes078
30G.S1.04 G.S3.03 11.11742.92944NoYes074
31b.l25x6 b.l27x1 77.662720.5292NoYes089
32G.H3.17 b.l25x6 15.0973.5969YesNo048
33G.H3.09 G.H4.15 12.9584.50584YesYes695
34G.H3.06 G.H4.15 17.65986.08097NoYes095
35G.H3.06 G.hgh4.02 35.96673.94268NoYes096
36G.HG.15 G.hgh4.02 18.16522.96823YesYes056
37G.HG.15 G.s4h3.04 19.09433.89709YesYes058
38G.H3.09 G.h4s6.01 13.53523.63876YesYes094
39G.H3.06 G.h4s6.01 18.05723.94813NoYes094
40G.hgh4.01 G.hgh4.02 16.93617.65144NoYes036
41G.hgh4.01 G.s4h3.04 16.83693.30643NoYes038
42G.S5.07 G.s6h5.01 33.42265.56403YesYes784
43G.S5.05 G.s6h5.01 32.15294.62113YesYes794
44G.h2s4.01 b.l5x5 29.54110.1728YesYes279
45G.S1.06 G.S4.03 12.17452.90779YesYes788
46b.l5x5 b.l7x2 56.78745.43731YesYes299
47G.s3h2.03 b.l7x2 28.46442.94YesYes299
48G.H2.07 G.h2s4.01 31.03583.69251YesYes297
49G.H2.07 b.l7x2 28.55473.67128YesYes299
50G.H2.07 b.l9x6 81.45334.01676YesYes298
51G.s3h2.03 b.l9x6 28.23095.05068YesYes298
52G.H2.06 b.l9x6 97.73753.09602YesYes288
53G.H2.04 G.H2.07 25.01554.80457NoYes099
54G.H2.04 G.H3.08 24.78853.08364NoNo095
55G.H2.06 b.l17x6 48.49498.32649YesNo289
56G.H2.06 b.b18x1 48.50734.17705YesNo089
57G.S5.03 G.S5.05 45.90173.32207YesYes769
58G.H3.08 G.S4.04 24.9774.98287NoYes057
59G.H5.10 G.S5.03 52.54363.21866NoYes046
60G.H5.10 G.S6.02 52.3394.57385NoYes045
61b.l2x5 b.l4x2 18.52925.8433NoYes054
62b.l4x2 g.ctx15 16.759711.3618YesYes349
63b.l26x5 g.ctx15 19.83985.55898NoYes059
64b.l26x5 g.ctx4 25.39415.74842NoNo057
65g.ctx3 g.ctx4 25.33533.68761YesNo097
66b.l22x1 g.ctx3 20.56326.8393NoYes099
67b.l22x1 g.ctx5 20.52253.24042NoNo099
68b.lhb1x11 g.ctx5 20.783.63415YesNo049
69b.b28x6 b.lhb1x11 27.28512.75411YesYes994
70b.b27x3 b.b28x6 12.21978.05694NoYes089
71b.b27x3 b.l25x3 70.03646.60399NoYes089
72b.l25x3 b.l27x2 77.88417.21126YesYes999
73b.b28x2 b.l27x2 70.5917.74825YesYes049
74I1x48 b.b28x2 78.13423.04742NoYes074
75I1x48 I1x51 77.98664.5513NoNo078
762x41 I1x51 77.82153.35069NoNo068
772x41 4x42 77.05363.79552NoNo067
782x42 4x42 76.90533.26726YesNo087
792x42 3x46 70.70823.01611YesNo089
803x46 3x50 14.69014.62097NoYes199
813x50 G.H5.25 35.9964.04716YesYes098
82G.H5.20 G.H5.25 48.57312.76199NoYes088
83G.H5.20 G.H5.26 49.10333.08424NoYes087
84G.H5.17 G.H5.26 51.24054.29051NoYes067
85G.H5.17 G.h4s6.12 25.4243.61622NoNo067
86G.S6.02 G.h4s6.12 25.4848.46225YesNo057
87b.b28x4 b.b28x6 17.32636.68068YesYes969
88G.H5.13 G.H5.17 26.04774.77878YesNo066
89G.H5.13 G.S6.02 26.39877.55797YesYes065
906x37 G.H5.25 19.02413.32337NoYes088
915x58 6x37 15.68086.52895YesNo098
923x50 5x58 16.99224.58156YesYes199
93b.l17x6 b.l19x1 52.16316.18852NoNo099
94b.l17x5 b.l19x1 1002.61652NoNo069
95b.l17x5 b.l19x2 99.5413.66589NoYes069
96b.b20x2 b.l19x2 29.53347.70567NoYes069
97b.b20x2 b.b20x4 28.59536.40411NoYes068
98b.b20x4 b.b20x6 54.33763.89557YesYes586
99b.b17x7 b.b20x6 75.78448.83426YesYes586
100b.b17x7 b.b21x1 71.54414.81882YesYes587
101b.1x19 b.b21x1 64.47168.47466NoYes067
102b.1x15 b.1x19 58.73743.98249NoNo076
103b.1x12 b.1x15 55.86921.53927NoNo067
104b.1x12 g.h1x11 36.45232.68699NoNo069
105b.1x11 g.h1x11 33.57864.39747NoNo089
106b.1x11 g.h1x12 29.26692.55655NoNo086
107g.h1x12 g.h1x9 26.39152.55268NoNo066
108g.h1x5 g.h1x9 15.5671.83599YesNo066
109b.b18x1 b.l19x1 48.29598.4257NoNo099
110b.l17x3 b.l19x2 68.6143.46489YesYes599
111b.b20x4 b.l17x3 28.595116.6516YesYes589
112b.b19x4 b.l17x3 38.14816.70529YesYes589
113b.b19x4 b.b20x6 27.17656.95323YesYes586
114b.1x12 b.1x9 18.03432.25071NoNo064
115b.l23x1 b.l25x6 79.359619.0611YesNo068
116b.l21x7 b.l23x1 19.45054.45103NoYes056
117b.l21x7 b.l23x2 18.91355.7908NoNo058
118b.b23x6 b.l23x2 17.5563.75233YesNo078
119b.b23x6 b.b24x6 14.27666.4067YesYes1478
120b.b21x7 b.b24x6 13.77827.8881YesYes058
121b.b2x4 b.b6x5 14.88383.08346NoYes066
122b.b10x4 b.b2x4 14.852312.244NoNo066
123b.b3x3 b.b4x3 12.99363.33825YesYes087
124b.b10x2 b.b10x4 14.08233.44621NoNo066
125b.b10x2 b.b6x2 15.32592.7633NoNo068
126b.b10x3 b.b6x2 15.3253.93844NoNo088
127b.b10x3 b.b11x4 15.48612.95261NoYes289
128b.b11x2 b.b12x6 10.91793.07249NoYes078
129b.b11x4 b.l9x3 14.79325.71952YesYes299
130b.b11x6 b.l9x3 27.629215.4527NoYes299
131b.l11x1 b.l9x6 25.67365.63631NoYes298
132b.b11x6 b.l11x1 29.33123.1081NoNo299
133b.b10x2 b.b14x3 10.74024.57026NoYes065
134b.b18x3 b.b19x4 10.51694.46867YesYes588
135b.b22x1 b.l23x1 65.65473.08027NoYes086
136b.b22x1 b.b22x2 65.46163.03775NoNo088
137b.b22x2 b.b26x3 65.28636.03499NoNo086
138b.l25x4 b.l27x2 11.87965.14699NoYes059
1398x56 b.l25x4 11.63283.03521NoNo065
1406x48 Lig 54.43893.97925YesYes180
1416x44 6x48 60.50495.59768YesYes198
1423x43 6x44 52.31022.71884YesYes189
1433x43 7x53 68.79847.07677YesYes189
1443x46 7x53 55.87934.37724NoYes199
1455x43 Lig 11.50773.88631NoYes080
1467x42 Lig 14.75748.14804YesYes180
1471x60 I1x50 10.2336.76055YesYes078
1481x60 8x56 11.19172.62196YesNo076
1495x39 5x43 11.11045.39547YesNo088
1505x54 5x58 21.99882.77443NoYes199
1516x51 7x34 13.0333.37228YesYes184
152b.1x6 b.1x9 10.83781.19804NoNo034
153G.S4.04 G.S5.04 19.50852.70984YesYes678
154b.b2x3 b.b2x5 13.9034.18947NoYes367
155b.b26x3 b.b27x3 64.5463.31981NoNo068
156b.b12x6 b.l9x3 11.08755.79308YesYes289
1573x50 7x53 14.56745.50739YesYes199
1585x54 6x44 22.53313.38354NoYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x32Lig11.4781NoYes8010
3x33Lig11.96521NoYes8010
3x36Lig7.276371NoYes7010
3x37Lig2.788590YesYes8010
5x43Lig3.886310NoYes8010
6x48Lig3.979251YesYes8010
6x51Lig12.16631YesYes8010
6x52Lig4.411731YesYes7010
7x38Lig9.634861YesYes7010
7x42Lig8.148041YesYes8010
2x563x328.10951NoNo8821
2x567x424.322081NoYes8821
2x577x392.761771YesYes8822
2x577x425.533821YesYes8821
2x607x392.639781YesYes7822
2x607x424.132091YesYes7821
3x327x429.133261NoYes8811
3x334x578.105831NoNo8811
3x344x532.657020NoNo6822
3x344x573.672930NoNo6821
3x366x484.06231NoYes7811
3x373x413.559570YesYes8712
3x374x533.953050YesNo8812
3x375x4614.198680YesNo8812
3x406x443.375881NoYes8922
3x406x488.983441NoYes8821
5x395x435.395471YesNo8821
5x446x523.59410NoYes7721
5x476x444.46531YesYes8922
5x476x483.837561YesYes8821
5x476x5215.60681YesYes8721
6x446x485.597681YesYes9821
6x486x524.755611YesYes8711
6x487x417.621651YesNo8811
6x487x459.980481YesNo8912
6x516x524.236941YesYes8711
6x516x555.777861YesNo8811
6x517x386.063231YesYes8711
7x387x426.150531YesYes7811
7x397x426.205181YesYes8821
6x55Lig4.008151NoYes8010
3x33E2x522.750651NoNo8612
6x517x343.372281YesYes8412
5x406x553.93791NoNo7821
2x607x385.236051YesYes7721
7x41Lig3.478171NoYes8010
4x57Lig2.68081NoYes8010
3x374x562.513070YesNo8812
5x46Lig2.194670NoYes5010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
81.25Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
81.25Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
81.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
80.00Single4U15Tiotropium4U15-M3-Tiotropium
80.00Single6OL9Tiotropium6OL9-M5-Tiotropium
80.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
80.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
80.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
78.57Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
75.00Single5CXVTiotropium5CXV-M1-Tiotropium
75.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
73.33Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
73.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
73.33Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
71.43Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
71.43Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
71.43Consensusalpha1_onOrthosteric Ligandalpha1a_on
71.43Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
71.43Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
71.43Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
68.75Single2YDVNECA2YDV-A2A-NECA
68.75Single4UHRCGS216804UHR-A2A-CGS21680
68.75Single5G53NECA5G53-A2A-NECA-Gs
68.75Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
68.75Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
68.75Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
68.75Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
68.75Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
68.75Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
68.75Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
68.75Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
66.67Single3NY8ICI118-5513NY8-β2-ICI118-551
66.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
66.67Single4MQSIperoxo4MQS-M2-Iperoxo
66.67Single4U14Tiotropium4U14-M3-Tiotropium
66.67Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
66.67Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
66.67Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
66.67Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
66.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
66.67Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
66.67Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
66.67Consensusalpha2_onOrthosteric Ligandalpha2b_on
66.67Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
66.67Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
66.67Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
66.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
66.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
66.67Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
66.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
66.67Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
64.71Single3D4STimolol3D4S-β2-Timolol
64.71Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
64.71Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
64.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
64.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
64.29Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
64.29Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
64.29Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
64.29Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
64.29Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
64.29Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
64.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
64.29Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
62.50Single2RH1S-Carazolol2RH1-β2-S-Carazolol
62.50Single2YCWS-Carazolol2YCW-β1-S-Carazolol
62.50Single5D6LS-Carazolol5D6L-β2-S-Carazolol
62.50Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
62.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
62.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
62.50Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
62.50Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
62.50Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
62.50Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
62.50Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
62.50Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
62.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
62.50Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
62.50Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
62.50Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
62.50Consensusamine_offonOrthosteric Ligandamine_off amine_on
62.50Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
62.50Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
62.50Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
62.50Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
62.50Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
62.50Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
62.50Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
62.50Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
62.50Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
60.00Single3RZECidoxepin3RZE-H1-Cidoxepin
60.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
60.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
60.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
60.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
60.00Single6PS4ICI118-5516PS4-β2-ICI118-551
60.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
60.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
60.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
60.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
60.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
60.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
60.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
60.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
60.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
60.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
60.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
60.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
60.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
60.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
60.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
60.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
60.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
60.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
60.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
60.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
60.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
58.82Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
58.82Single5D5AS-Carazolol5D5A-β2-S-Carazolol
58.82Single5D5BS-Carazolol5D5B-β2-S-Carazolol
58.82Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
58.82Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
58.82Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
58.82Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
58.82Single8EA0Iperoxo8EA0-M3-Iperoxo
58.82Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
58.82Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
58.82Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
58.82Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
58.82Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
58.82Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
58.82Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
58.82Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
57.89Single4UG2CGS216804UG2-A2A-CGS21680
57.89Single7SK9CCX6627SK9-ACKR3-CCX662
57.14Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
57.14Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
57.14Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
57.14Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
57.14Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
56.25Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
56.25Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
56.25Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
56.25Single4DAJTiotropium4DAJ-M3-Tiotropium
56.25Single4EJ4Naltrindole4EJ4-δ-Naltrindole
56.25Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
56.25Single5DSGTiotropium5DSG-M4-Tiotropium
56.25Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
56.25Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
56.25Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
56.25Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
56.25Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
56.25Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
56.25Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
56.25Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
56.25Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
56.25Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
56.25Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
56.25Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
56.25Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
56.25Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
56.25Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
56.25Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
56.25Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
56.25Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
56.25Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
56.25Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
56.25Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
56.25Single8JJOAlprenolol8JJO-β2-Alprenolol
56.25Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
56.25Single8JXRLSD8JXR-D1-LSD
56.25Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
56.25Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
56.25Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
56.25Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
56.25Single8X63Mepyramine8X63-H1-Mepyramine
56.25Single8X64Desloratadine8X64-H1-Desloratadine
56.25Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
56.25Single9CHXS-Carazolol9CHX-β2-S-Carazolol
56.25Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
56.25Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
56.25Consensus5ht5_onOrthosteric Ligand5ht5a_on
56.25Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
56.25Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
56.25Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
56.25Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
56.25Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
56.25Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
56.25Consensushistamine_offOrthosteric Ligandh1_off
56.25Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
55.56Single4AMIBucindolol4AMI-β1-Bucindolol
55.56Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
55.56Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
55.56Single7YITNalfurafine7YIT-κ-Nalfurafine
55.56Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
55.56Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
55.56Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
55.56Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
55.56Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
55.56Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
55.56Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
55.56Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
55.56Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
55.56Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
55.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
55.00Single8WDTphotoNECA8WDT-A2A-photoNECA
53.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
53.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
53.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
53.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
53.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
53.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
53.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
53.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
53.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
53.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
53.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
53.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
53.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
53.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
53.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
53.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
53.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
53.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.33Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
52.94Single5C1MBU725C1M-μ-BU72
52.94Single5JQHS-Carazolol5JQH-β2-S-Carazolol
52.94Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
52.94Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
52.94Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
52.94Single6PS6Timolol6PS6-β2-Timolol
52.94Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
52.94Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
52.94Single7WC6LSD7WC6-5-HT2A-LSD
52.94Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
52.94Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
52.94Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
52.94Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
52.94Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
52.94Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
52.94Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
52.94Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
52.94Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
52.94Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
52.94Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
52.94Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
52.94Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
52.94Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
52.94Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
52.94Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.94Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
52.94Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
52.94Consensustrace-amine_onOrthosteric Ligandta1_on
52.63Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
52.63Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
52.63Single5X93K-87945X93-ETB-K-8794
52.63Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
52.63Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
52.63Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
52.63Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
52.63Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
52.63Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
52.63Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
52.63Consensusendothelin_offOrthosteric Ligandetb_off
52.63Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
50.00Single2YDOAdenosine2YDO-A2A-Adenosine
50.00Single3NY9ICI118-5513NY9-β2-ICI118-551
50.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
50.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
50.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
50.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
50.00Single5WF5UK-4320975WF5-A2A-UK-432097
50.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
50.00Single6J21Aprepitant6J21-NK1-Aprepitant
50.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
50.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
50.00Single6PT3DPI-2876PT3-δ-DPI-287
50.00Single6TPGEMPA6TPG-OX2-EMPA
50.00Single6TPNHTL66416TPN-OX2-HTL6641
50.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
50.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
50.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
50.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
50.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
50.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
50.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
50.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
50.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
50.00Single8E0GBU728E0G-μ-BU72
50.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
50.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
50.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
50.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
50.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
50.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
50.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
50.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
50.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
50.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
50.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
50.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
50.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
50.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
50.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
50.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
50.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
50.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
50.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
50.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
50.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single8XVLZibotentan8XVL-ETA-Zibotentan
50.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
50.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
50.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
50.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
50.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
50.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
50.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
50.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
50.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
50.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
50.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
50.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
50.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
50.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
50.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
47.62Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
47.62Single4IARErgotamine4IAR-5-HT1B-Ergotamine
47.62Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
47.62Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
47.62Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
47.37Single4LDEBI1671074LDE-β2-BI167107
47.37Single4RWADIPP-NH24RWA-δ-DIPP-NH2
47.37Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
47.37Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
47.37Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
47.37Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
47.37Single6ZG4HTL00099366ZG4-M1-HTL0009936
47.37Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
47.37Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
47.37Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
47.37Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
47.37Single8JJ8Formoterol8JJ8-β2-Formoterol
47.37Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
47.37Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
47.37Consensusalpha1_offOrthosteric Ligandalpha1a_off
47.37Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
47.37Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
47.37Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
47.37Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
47.37Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
47.37Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
47.06Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
47.06Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
47.06Single2Y04Salbutamol2Y04-β1-Salbutamol
47.06Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
47.06Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
47.06Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
47.06Single6H7MSalbutamol6H7M-β1-Salbutamol
47.06Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
47.06Single6PS1Timolol6PS1-β2-Timolol
47.06Single6TOTLemborexant6TOT-OX1-Lemborexant
47.06Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
47.06Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
47.06Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
47.06Single7WC7Lisuride7WC7-5-HT2A-Lisuride
47.06Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
47.06Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
47.06Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
47.06Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
47.06Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
47.06Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
47.06Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
47.06Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
47.06Single8T1WCVN4248T1W-GPR6-CVN424
47.06Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
47.06Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
47.06Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
47.06Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
47.06Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
47.06Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
47.06Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
46.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
46.67Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
46.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
46.67Single3PBLEticlopride3PBL-D3-Eticlopride
46.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
46.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
46.67Single7SRQLSD7SRQ-5-HT2B-LSD
46.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
46.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
46.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
46.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
46.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
46.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
46.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
46.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
46.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
46.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
46.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
46.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
46.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
46.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
46.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
46.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
46.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
45.45Single3QAKUK-4320973QAK-A2A-UK-432097
45.45Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
45.45Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
45.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
45.00Single6H7LDobutamine6H7L-β1-Dobutamine
45.00Single6IBLArformoterol6IBL-β1-Arformoterol
45.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
45.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
45.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
45.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
45.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
45.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
45.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
45.00Single8XVJMacitentan8XVJ-ETA-Macitentan
45.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
45.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
45.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
45.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
44.44Single2Y03Isoprenaline2Y03-β1-Isoprenaline
44.44Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
44.44Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
44.44Single5TVNLSD5TVN-5-HT2B-LSD
44.44Single5WQCEMPA5WQC-OX2-EMPA
44.44Single5XPRBosentan5XPR-ETB-Bosentan
44.44Single6E67BI1671076E67-β2-BI167107-Gs (fused)
44.44Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
44.44Single6HLPNetupitant6HLP-NK1-Netupitant
44.44Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
44.44Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
44.44Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
44.44Single6TP6Filorexant6TP6-OX1-Filorexant
44.44Single7C61Ergotamine7C61-5-HT1B-Ergotamine
44.44Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
44.44Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
44.44Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
44.44Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
44.44Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
44.44Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
44.44Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
44.44Single8ZMFA1L108ZMF-5-HT2C-A1L10
44.44Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
44.44Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
44.44Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
43.75Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
43.75Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
43.75Single6AKXA4R6AKX-CCR5-A4R
43.75Single6B73MP11046B73-κ-MP1104
43.75Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
43.75Single6TODEMPA6TOD-OX1-EMPA-Na
43.75Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
43.75Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
43.75Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
43.75Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
43.75Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
43.75Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
43.75Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
43.75Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
43.75Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
43.75Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
43.75Single8IWESpermidine8IWE-TA9-Spermidine
43.75Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8Y0HVUF114188Y0H-CXCR3-VUF11418
43.75Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
43.75Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
43.75Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
43.75Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
43.75Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
43.75Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
43.75Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
43.48Single6PT2KGCHM076PT2-δ-KGCHM07
43.48Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
42.86Single5WF6UK-4320975WF6-A2A-UK-432097
42.86Single5ZTYAM102575ZTY-CB2-AM10257
42.86Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
42.86Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
42.86Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
42.86Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
42.86Single9CHUNoradrenaline9CHU-β2-Noradrenaline
42.86Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
42.86Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
42.86Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
42.11Single3P0GBI1671073P0G-β2-BI167107
42.11Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
42.11Single4DJHJDTic4DJH-κ-JDTic
42.11Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
42.11Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
42.11Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
42.11Single6WGTLSD6WGT-5-HT2A-LSD
42.11Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
42.11Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
42.11Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
42.11Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
42.11Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
42.11Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
42.11Consensusa2_onOrthosteric Liganda2b_on
42.11Consensusa2_on_gpOrthosteric Liganda2b_on_gp
42.11Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
42.11Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
42.11Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
42.11Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
42.11Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
42.11Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
42.11Consensustachykinin_offOrthosteric Ligandnk1_off
41.18Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
41.18Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
41.18Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
41.18Single4MBSMaraviroc4MBS-CCR5-Maraviroc
41.18Single4ZJCSB-6740424ZJC-OX1-SB-674042
41.18Single6A94Zotepine6A94-5-HT2A-Zotepine
41.18Single6KUXRS-799486KUX-α2a-RS-79948
41.18Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
41.18Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
41.18Single6VI4JDTic6VI4-κ-JDTic
41.18Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
41.18Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
41.18Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.18Single7UL3Famotidine7UL3-H2-Famotidine
41.18Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
41.18Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
41.18Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
41.18Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
41.18Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
41.18Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
41.18Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
41.18Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
41.18Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
41.18Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
41.18Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
41.18Consensusopsins_offOrthosteric Ligandrhodopsin_off
41.18Consensussensory_offOrthosteric Ligandopsins_off
40.91Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.91Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
40.91Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
40.91Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
40.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
40.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
40.00Single6A93Risperidone6A93-5-HT2A-Risperidone
40.00Single6CM4Risperidone6CM4-D2-Risperidone
40.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single7DFPSpiperone7DFP-D2-Spiperone
40.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
40.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
40.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
40.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
40.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
40.00Single8JJLOlodaterol8JJL-β2-Olodaterol
40.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
40.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
40.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
40.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
40.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
40.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
40.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
40.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
40.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
40.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
40.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
39.13Single6HLOAprepitant6HLO-NK1-Aprepitant
38.89Single2Y01Dobutamine2Y01-β1-Dobutamine
38.89Single2Y02Carmoterol2Y02-β1-Carmoterol
38.89Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
38.89Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
38.89Single4QKX35V4QKX-β2-35V
38.89Single5DHHSB-6121115DHH-NOP-SB-612111
38.89Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
38.89Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
38.89Single6DRXLisuride6DRX-5-HT2B-Lisuride
38.89Single7BU7BI1671077BU7-β1-BI167107
38.89Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
38.89Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
38.89Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
38.89Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
38.89Single7UL4Alvimopan7UL4-μ-Alvimopan
38.89Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
38.89Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
38.89Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
38.89Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
38.89Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
38.89Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
38.89Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
38.89Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
38.89Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
38.89Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
38.89Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
38.89Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
38.89Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusblt_onOrthosteric Ligandblt1_on
38.89Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
38.89Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
38.89Consensusleukotriene_onOrthosteric Ligandblt_on
38.89Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
38.10Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
38.10Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
38.10Single7EZCUKA7EZC-A2A-UKA
38.10Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
38.10Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
38.10Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
38.10Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
37.50Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
37.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
37.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
37.50Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
37.50Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
37.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
37.50Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
37.50Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
37.50Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
36.84Single2Y00Dobutamine2Y00-β1-Dobutamine
36.84Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.84Single5WIUNemonapride5WIU-D4-Nemonapride
36.84Single5WIVNemonapride5WIV-D4-Nemonapride-Na
36.84Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.84Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
36.84Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
36.84Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
36.84Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
36.84Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
36.84Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
36.84Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
36.84Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
36.84Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
36.84Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
36.84Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
36.84Consensusa3_on_gpOrthosteric Liganda3a_on_gp
36.84Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.36Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
36.36Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.71Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
35.71Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
35.29Single4S0VSuvorexant4S0V-OX2-Suvorexant
35.29Single5WS3EMPA5WS3-OX2-EMPA
35.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
35.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
35.29Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
35.29Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.29Single6TPJSuvorexant6TPJ-OX2-Suvorexant
35.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
35.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
35.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
35.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
35.29Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
35.29Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
35.29Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
35.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
35.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
35.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.29Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
35.29Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.29Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
35.29Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
35.29Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
35.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
35.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
35.00Single6E59L-7607356E59-NK1-L-760735
35.00Single6J20Aprepitant6J20-NK1-Aprepitant
35.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
35.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
35.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
35.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
35.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
35.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
35.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
35.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
35.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
35.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
35.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
35.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
35.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
35.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
35.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
35.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
34.78Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
34.78Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
34.78Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
34.62Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
33.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
33.33Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6TP3Nemorexant6TP3-OX1-Nemorexant
33.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
33.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
33.33Single8JWY2-1188JWY-A2A-2-118
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
33.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
33.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
33.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
33.33Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Consensussensory_onOrthosteric Ligandopsins_on
32.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
32.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
32.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
31.82Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
31.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.82Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.82Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
31.82Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
31.82Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
31.82Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
31.82Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
31.82Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
31.82Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
31.82Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
31.82Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
31.58Single5DHGC-355DHG-NOP-C-35
31.58Single5TGZAM65385TGZ-CB1-AM6538
31.58Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
31.58Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58Single8CU6LJ-45178CU6-A2A-LJ-4517
31.58Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
31.58Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.58Single8RLNLUF58348RLN-A2A-LUF5834
31.58Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
31.58Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
31.58Consensusa3_onOrthosteric Liganda3a_on
31.25Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
31.25Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
31.25Single3UZAGTPL92363UZA-A2A-GTPL9236
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
31.25Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.77Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.77Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
30.77Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
30.43Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
30.43Single7XN9L-054,5227XN9-SST2-L-054,522
30.43Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
30.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
30.00Single5CGCHTL142425CGC-mGlu5-HTL14242
30.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
30.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7W41PD1762527W41-BB2-PD176252
30.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
30.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
30.00Single8JXSPF-61428JXS-D1-PF-6142
30.00Single8S4DCMF-0198S4D-Apelin-CMF-019
30.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
30.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
30.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
30.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
30.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
30.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
30.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
30.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
30.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbombesin_offOrthosteric Ligandbb2_off
30.00Consensusbombesin_onOrthosteric Ligandbb2_on
30.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
30.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
29.63Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
29.63Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
29.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
29.41Single6HLLCP999946HLL-NK1-CP99994
29.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
29.41Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
29.41Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
29.41Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
29.41Single6TP4ACT-4622066TP4-OX1-ACT-462206
29.41Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.41Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
29.41Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
29.41Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
29.41Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
29.41Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
29.17Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
29.17Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
29.17Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
29.17Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.17Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
28.57Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
28.57Single5XRAAM115425XRA-CB1-AM11542
28.57Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
28.57Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.57Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
28.57Single7P2L4YI7P2L-mGlu5-4YI
28.57Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
28.57Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
28.57Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
28.57Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
28.57Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
28.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
28.57Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
28.57Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
28.57Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
28.57Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
28.57Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
28.57Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
28.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
28.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
27.78Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
27.78Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
27.78Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
27.78Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
27.78Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.78Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
27.78Single7F8ULintitript7F8U-CCKA-Lintitript
27.78Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
27.78Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
27.78Single7XRRLemborexant7XRR-OX2-Lemborexant
27.78Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
27.78Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
27.78Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
27.78Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
27.78Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
27.78Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
27.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
27.59Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
27.59Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
27.27Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.27Single7K15MKD0467K15-BLT1-MKD046-Na
27.27Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
27.27Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
27.27Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
27.27Single8XYIVUF106618XYI-CXCR3-VUF10661
27.27Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
27.27Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
27.27Consensuslpl_offOrthosteric Ligands1p_off lpa_off
27.27Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
26.92Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.92Consensusangiotensin_onOrthosteric Ligandat1_on
26.92Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.92Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
26.92Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
26.92Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
26.92Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
26.67Single6IGLIRL16206IGL-ETB-IRL1620
26.67Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.32Single5JTBZM-2413855JTB-A2A-ZM-241385
26.32Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.32Single6AQFZM-2413856AQF-A2A-ZM-241385
26.32Single6FFIMMPEP6FFI-mGlu5-MMPEP
26.32Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
26.32Single6TPKRetosiban6TPK-OT-Retosiban
26.32Single6V9SGTPL114036V9S-OX1-GTPL11403
26.32Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.32Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.32Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.32Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.32Single7T32ZM-2413857T32-A2A-ZM-241385
26.32Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.32Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.32Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
26.32Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
26.32Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.32Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
26.32Consensusa2_offOrthosteric Liganda2a_off
26.32Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
26.32Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.32Consensusvasop-oxy_offOrthosteric Ligandot_off
26.09Single5CGDHTL142425CGD-mGlu5-HTL14242
26.09Single6K1QIRL25006K1Q-ETB-IRL2500
26.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
26.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
26.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
26.09Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
26.09Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.09Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
25.93Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.93Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.93Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
25.93Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.93Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
25.93Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.93Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.93Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.93Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.93Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
25.93Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.93Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
25.81Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Single3EMLZM-2413853EML-A2A-ZM-241385
25.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
25.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
25.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
25.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6FFHFenobam6FFH-mGlu5-Fenobam
25.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
25.00Single6S0LZM-2413856S0L-A2A-ZM-241385
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
25.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
25.00Single8ZRTET-18ZRT-ETB-ET-1
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
25.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.00Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
25.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.14Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
24.14Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
24.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.00Single7F8XNN90567F8X-CCKA-NN9056
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
24.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
24.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
24.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
24.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
23.81Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.81Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.81Single5N2RPSB-365N2R-A2A-PSB-36-Na
23.81Single5N2SPSB365N2S-A1-PSB36
23.81Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6S0QZM-2413856S0Q-A2A-ZM-241385
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
23.81Single7C4SS1P7C4S-S1P3-S1P
23.81Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
23.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
23.81Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
23.81Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
23.81Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
23.81Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.81Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.81Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
23.81Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
23.81Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.81Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.81Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.81Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
23.53Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
23.53Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
23.53Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.53Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
23.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.53Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.53Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.53Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Consensusgi_sensoryOrthosteric Ligandgi_opsins
23.53Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
23.33Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
23.33Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
23.08Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
23.08Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
23.08Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
23.08Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
23.08Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
23.08Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
23.08Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
23.08Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
23.08Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
22.73Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
22.73Single5XR8AM8415XR8-CB1-AM841
22.73Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.73Single7FEECP559407FEE-CB1-CP55940-ZCZ011
22.73Single7PX4PSB-21137PX4-A2A-PSB-2113
22.73Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.73Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.73Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
22.73Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
22.73Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
22.73Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
22.73Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
22.73Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
22.73Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
22.73Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
22.73Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.58Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.58Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
22.58Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.58Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbradykinin_onOrthosteric Ligandbk2_on
22.58Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
22.58Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.58Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.58Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
22.22Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
22.22Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
22.22Single8K5BNiacin8K5B-HCA2-Niacin
22.22Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
22.22Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
22.22Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.88Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.88Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.88Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.88Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
21.74Single4N4WSANT-14N4W-SMO-SANT-1
21.74Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
21.74Single6KQICP559406KQI-CB1-CP55940-Org27569
21.74Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.74Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
21.74Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
21.74Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
21.74Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.74Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
21.74Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.74Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
21.74Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
21.74Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.74Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.74Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
21.74Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
21.43Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
21.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
21.43Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
21.43Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
21.21Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.05Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
21.05Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
21.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.05Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
21.05Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.05Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.05Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
21.05Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
21.05Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.05Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
21.05Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.05Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.05Consensusangiotensin_offOrthosteric Ligandat1_off
21.05Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.05Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.05Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.83Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
20.83Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.83Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.83Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.83Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.83Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.83Consensuschemerin_onOrthosteric Ligandcml1_on
20.83Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusprostanoid_offOrthosteric Ligandep_off dp_off
20.83Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.83Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.83Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.69Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.69Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.69Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
20.69Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
20.69Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.69Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.59Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.59Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
20.00Single3REYXAC3REY-A2A-XAC
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
20.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
20.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
20.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8K5CAcipimox8K5C-HCA2-Acipimox
20.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
20.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
20.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.00Consensushca_onOrthosteric Ligandhca2_on
20.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
19.35Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
19.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
19.35Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
19.35Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
19.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
19.35Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.23Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
19.23Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single8IEBA1LYA8IEB-GPR156-A1LYA
19.23Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Single8WKYPG-9348WKY-MC4-PG-934
19.23Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
19.23Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.05Single4YAYZD-71554YAY-AT1-ZD-7155
19.05Single5UENDU1725UEN-A1-DU172
19.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
19.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.05Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
19.05Single6GPSMK08126GPS-CCR2-MK0812
19.05Single6IIVDaltroban6IIV-TP-Daltroban
19.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
19.05Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
19.05Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
19.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.05Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
19.05Single7F83PF-051904577F83-Ghrelin-PF-05190457
19.05Single7V3ZCP559407V3Z-CB1-CP55940
19.05Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
19.05Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
19.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.05Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
19.05Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.05Single8K5DGSK2560738K5D-HCA2-GSK256073
19.05Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
19.05Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
19.05Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
19.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
19.05Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
19.05Single9IYAONO-97105319IYA-GPR55-ONO-9710531
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
19.05Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
19.05Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Consensushca_on_gpOrthosteric Ligandhca2_on_gp
19.05Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
19.05Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
19.05Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
18.75Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.75Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
18.75Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.75Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.75Single8PWNTheophylline8PWN-A2A-Theophylline
18.75Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
18.75Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.52Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
18.52Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
18.52Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
18.52Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.52Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.52Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.52Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.52Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.52Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.18Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
18.18Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single6GPXMK08126GPX-CCR2-MK0812
18.18Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.18Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
18.18Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.18Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.18Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
18.18Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
18.18Consensusblt_offOrthosteric Ligandblt1_off
18.18Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.18Consensusdp_offOrthosteric Liganddp2_off
18.18Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
18.18Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.18Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.86Single6W25SHU91196W25-MC4-SHU9119-Ca
17.86Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.86Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
17.86Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.86Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.86Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.86Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.65Single3RFMCaffeine3RFM-A2A-Caffeine
17.65Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.65Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
17.65Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
17.39Single5TZRMK86665TZR-FFA1-MK8666
17.39Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.39Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.39Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.39Single7R0CAVP7R0C-V2-AVP-Arrestin2
17.39Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
17.39Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
17.39Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
17.39Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
17.39Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
17.39Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
17.39Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
17.39Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.39Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Consensuslpa_onOrthosteric Ligandlpa1_on
17.39Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.39Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.24Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
17.24Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.24Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.24Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.24Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.24Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.24Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.24Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
16.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.67Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
16.67Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
16.67Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.13Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.13Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.13Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
16.13Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
16.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
16.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.79Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
15.79Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
15.79Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
15.79Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
15.79Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
15.79Single9B9Y7DY9B9Y-CB1-7DY
15.79Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
15.79Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.79Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.62Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
15.62Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.62Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.62Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.62Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.38Single5EE7MK08935EE7-Glucagon-MK0893
15.38Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
15.38Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
15.38Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
15.38Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.15Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.15Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.15Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.15Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.15Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
15.00Single3PWHZM-2413853PWH-A2A-ZM-241385
15.00Single5U09Taranabant5U09-CB1-Taranabant
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
15.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
15.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
15.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
15.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
15.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.81Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
14.81Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
14.81Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
14.81Single8IEIA1LYA8IEI-GPR156-A1LYA
14.81Single8IEPA1LYA8IEP-GPR156-A1LYA
14.81Single8IEPA1LYA8IEP-GPR156-A1LYA
14.81Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
14.81Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
14.81Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.81Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.81Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
14.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.71Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.71Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.71Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
14.71Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
14.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
14.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
14.29Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
14.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
14.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.29Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
14.29Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8IEBA1LYA8IEB-GPR156-A1LYA
14.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
14.29Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
14.29Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
14.29Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
14.29Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
14.29Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
14.29Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
14.29Consensusgrh_offOrthosteric Ligandgnrh1_off
14.29Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.89Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
13.79Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.79Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
13.79Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
13.79Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
13.79Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
13.79Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
13.79Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.79Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
13.79Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.64Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
13.64Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.64Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.64Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.64Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.64Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
13.64Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.64Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
13.64Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.51Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
13.51Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
13.51Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
13.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
13.33Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
13.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
13.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
13.33Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
13.33Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.33Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
13.33Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
13.33Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
13.16Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.04Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.04Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.04Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.04Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.04Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
13.04Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
13.04Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.04Consensusep_offOrthosteric Ligandep4_off
13.04Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.04Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.04Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
12.90Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
12.90Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
12.90Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
12.90Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
12.90Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
12.90Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6FJ3PTH6FJ3-PTH1-PTH
12.50Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
12.50Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
12.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
12.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
12.50Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.50Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
12.50Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
12.50Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
12.50Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
12.50Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.50Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
12.50Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.50Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9BJKNAM9BJK-μ-Naloxone-NAM
12.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.50Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Consensusrelaxin_onOrthosteric Ligandrxfp4_on
12.50Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
12.20Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.12Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
12.12Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.12Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.12Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
12.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
12.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
12.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
12.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.90Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.76Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
11.76Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
11.76Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
11.76Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
11.76Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
11.76Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
11.76Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
11.76Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.54Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
11.54Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
11.54Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
11.54Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
11.54Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
11.43Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
11.11Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
11.11Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.11Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
11.11Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.11Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.11Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
11.11Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
11.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.81Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single4XT1Fractalkine4XT1-US28-Fractalkine
10.71Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8KIGSHU91198KIG-MC3-SHU9119-Ca
10.71Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
10.71Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single3OE6IT1t3OE6-CXCR4-IT1t
10.53Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.53Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
10.53Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
10.53Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.34Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
10.34Single7SHEPI; PE7SHE-GPR158-PI; PE
10.34Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.34Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
10.34Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.00Single3OE0CVX153OE0-CXCR4-CVX15
10.00Single3OE9IT1t3OE9-CXCR4-IT1t
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
10.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
10.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.68Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
9.68Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
9.68Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
9.68Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
9.68Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
9.68Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
9.68Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
9.52Single3ODUIT1t3ODU-CXCR4-IT1t
9.52Single5ZKQABT-4915ZKQ-PAF-ABT-491
9.52Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.52Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.52Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
9.52Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
9.52Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
9.52Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.52Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
9.52Single9BA0A1AKN9BA0-CB1-A1AKN
9.52Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
9.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
9.38Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
9.38Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
9.38Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.38Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
9.38Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
9.38Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
9.38Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
9.38Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
9.38Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
9.09Single4XT3Fractalkine4XT3-US28-Fractalkine
9.09Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
9.09Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.09Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
9.09Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.09Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.09Single8IYXYL-3658IYX-GPR34-YL-365
9.09Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
9.09Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
9.09Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.09Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
9.09Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
9.09Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
8.82Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
8.82Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
8.82Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
8.70Single4QIMANTA XV4QIM-SMO-ANTA XV
8.70Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
8.70Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
8.57Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
8.57Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
8.33Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.33Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.11Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.00Single5V56TC1145V56-SMO-TC114
8.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
8.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
7.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
7.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
7.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
7.69Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
7.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.69Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
7.69Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
7.69Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.41Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.41Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
7.41Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
7.41Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
7.41Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
7.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.14Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.14Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.14Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.90Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.90Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
6.90Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.90Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
6.90Consensussomatostatin_offOrthosteric Ligandsst2_off
6.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
6.67Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.67Single7SK5CXCL127SK5-ACKR3-CXCL12
6.67Single7XNACYN1548067XNA-SST2-CYN154806
6.67Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.67Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
6.67Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
6.45Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
6.45Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.45Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.45Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.45Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.25Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.25Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
6.06Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.06Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.06Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
5.88Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
5.88Single7SK3CXCL127SK3-ACKR3-CXCL12
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.71Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.71Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
5.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.56Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
5.56Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.56Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.56Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.26Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.26Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.26Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.26Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
5.00Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
5.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.76Single6LI0C176LI0-GPR52-C17
4.76Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
4.76Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
4.76Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
4.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.76Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8K9LVV98K9L-μ-Damgo-VV9-Gi3/β1/γ1
4.55Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.55Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
4.55Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.55Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.55Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.55Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.55Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.55Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.35Single5O9HNDT95137275O9H-C5a1-NDT9513727
4.35Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.35Single6ZINSR486926ZIN-NTS1-SR48692
4.35Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
4.35Single7VV6C48/807VV6-MRGPRX2-C48/80
4.35Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.17Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.17Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
4.17Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.17Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.17Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.17Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.00Single4JKVTaladegib4JKV-SMO-Taladegib
4.00Single6Z4SSR486926Z4S-NTS1-SR48692
4.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.85Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
3.85Single4BV0Neurotensin4BV0-NTS1-Neurotensin
3.85Single5V57TC1145V57-SMO-TC114
3.85Single6OS1TRV0266OS1-AT1-TRV026
3.85Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
3.85Single7F1TMIP-1a7F1T-CCR5-MIP-1a
3.85Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
3.85Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
3.85Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
3.85Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.85Consensusneurotensin_onOrthosteric Ligandnts1_on
3.85Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.70Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.70Single4XEENeurotensin4XEE-NTS1-Neurotensin
3.70Single4XESNeurotensin4XES-NTS1-Neurotensin
3.70Single6OS2TRV0266OS2-AT1-TRV026
3.70Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.70Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
3.70Single8XQJJN2418XQJ-Apelin-JN241
3.70Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
3.70Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.70Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.70Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.57Single4BUONeurotensin4BUO-NTS1-Neurotensin
3.57Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.57Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.57Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.57Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
3.57Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.57Single8XVUCXCL28XVU-CXCR2-CXCL2
3.57Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.45Single6KNMJN241-96KNM-Apelin-JN241-9
3.45Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.45Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.45Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.45Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
3.33Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.33Single8XWNCXCL88XWN-CXCR2-CXCL8
3.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.12Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2

Consensus Members
Id Members
gi_5ht 8FYT-5-HT1A-LSD-Gi1/β1/γ1
7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
7E32-5-HT1D-Serotonin-Gi1/β1/γ2
7XTA-5-HT4-Serotonin-Gi1/β1/γ2
8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
7X5H-5-HT5A-5-CT-Gi1/β1/γ2
8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
7E33-5-HT1E-BRL-54443-Gi1/β1/γ2
8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
gi_muscarinic 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7TRS-M4-Acetylcholine-Gi1/β1/γ2
7TRK-M4-Iperoxo-Gi1/β1/γ2
7V6A-M4-PubChem 9864275-Gi1/β1/γ2
gi_adrenergic 7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
7EJK-α2a-Oxymetazoline-Go/β1/γ2
7W7E-α2a-PubChem 164946676-Go/β1/γ2
7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
7EJ8-α2a-Brimonidine-Go/β1/γ2
6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
7EJA-α2a-Dexmedetomidine-Go/β1/γ2
7S0F-β1-Isoprenaline-Gi1/β1/γ2
gi_dopamine 7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
7CMV-D3-PD128907-Gi1/β1/γ2
7CMU-D3-Pramipexole-Gi1/β1/γ2
8IRS-D2-Rotigotine-Gi1/β1/γ2
8IRT-D3-Rotigotine-Gi1/β1/γ2
gi_histamine 8JXX-H4-Clobenpropit-Gi1/β1/γ2
8JXV-H4-Clozapine-Gi1/β1/γ2
8YUU-H3-Histamine-Gi1/β1/γ1
8HN8-H4-Histamine-Gi1/β1/γ2
8HOC-H4-Imetit-Gi1/β1/γ2
8JXW-H4-VUF6884-Gi1/β1/γ2
Net Summary
Imin 2.63412
Number of Linked Nodes 937
Number of Links 1145
Number of Hubs 192
Number of Links mediated by Hubs 715
Number of Communities 25
Number of Nodes involved in Communities 250
Number of Links involved in Communities 367
Path Summary
Number Of Nodes in MetaPath 159
Number Of Links MetaPath 158
Number of Shortest Paths 2850206
Length Of Smallest Path 3
Average Path Length 29.574
Length of Longest Path 58
Minimum Path Strength 0.240774
Average Path Strength 5.19949
Maximum Path Strength 22.1062
Minimum Path Correlation 0.700261
Average Path Correlation 0.967919
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 35.3287
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.4898
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_class-agi_peptide
gi_sensory
gi_alicarboxylic
gi_amine
gi_lipid
gi_nucleotide
gi_protein



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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