Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:K28 4.3925404
2A:A:L45 3.8725468
3A:A:K53 3.86469
4A:A:F219 6.0185108
5A:A:H220 6.214137
6A:A:M221 4.7775468
7A:A:F222 7.21754137
8A:A:R231 5.2475409
9A:A:R232 4.8408
10A:A:K233 5.155409
11A:A:I244 3.23408
12A:A:V247 2.28467
13A:A:D249 4.5475468
14A:A:Y253 3.294508
15A:A:W277 6.7925166
16A:A:W281 4.9725405
17A:A:L289 2.724149
18A:A:F312 3.8408
19A:A:F315 10.80754156
20A:A:P326 2.344171
21A:A:V334 3.6675404
22A:A:Y339 4.55254173
23A:A:S349 2.9407
24A:A:Y360 5.876676118
25A:A:N371 3.9325409
26A:A:R374 3.50254114
27A:A:F376 3.206676108
28A:A:L388 2.555408
29B:B:L7 4.01754198
30B:B:L14 5.44408
31B:B:I37 3.505492
32B:B:V40 2.634593
33B:B:L51 5.845409
34B:B:H54 5.4575409
35B:B:Y59 10.4075438
36B:B:M61 2.7486
37B:B:W63 4.2325487
38B:B:R68 9.08485
39B:B:V71 3.5625408
40B:B:S74 4.4025439
41B:B:D76 4.342539
42B:B:K78 4.6625408
43B:B:L79 2.225407
44B:B:W82 7.896509
45B:B:S84 2.862585
46B:B:Y85 8.7175484
47B:B:H91 4.645405
48B:B:I93 3.3175407
49B:B:L95 2.94228
50B:B:W99 3.99409
51B:B:Y105 3.5175406
52B:B:A106 1.9725426
53B:B:S108 4.2175426
54B:B:N110 4.2225424
55B:B:Y111 2.5875404
56B:B:A113 1.9975429
57B:B:C114 2.56754228
58B:B:Y124 5.2875406
59B:B:H142 5.866529
60B:B:C149 1.728528
61B:B:F151 3.856529
62B:B:L152 2.84403
63B:B:I157 3.12167627
64B:B:T159 2.7525429
65B:B:S160 2.8775446
66B:B:S161 5.564529
67B:B:D163 6.404529
68B:B:W169 6.265628
69B:B:F180 6.124547
70B:B:H183 6.578549
71B:B:D186 3.36429
72B:B:V187 4.9425449
73B:B:L190 2.80333645
74B:B:A193 1.94414
75B:B:F199 5.6975449
76B:B:V200 3.9275416
77B:B:S201 2.868549
78B:B:K209 7.6925446
79B:B:L210 3.252515
80B:B:W211 7.202548
81B:B:Q220 5.14417
82B:B:F222 4.432518
83B:B:H225 6.94857719
84B:B:I232 3.4625418
85B:B:F234 3.5175415
86B:B:F235 4.822516
87B:B:N237 6.3625415
88B:B:F241 4.66416
89B:B:T243 4.142518
90B:B:D247 7.2519
91B:B:R251 7.992518
92B:B:F253 5.8375416
93B:B:D254 3.585409
94B:B:Q259 5.5965206
95B:B:E260 7.5175416
96B:B:Y264 3.534505
97B:B:H266 4.954514
98B:B:I273 3.35416
99B:B:V276 1.665416
100B:B:F278 4.224517
101B:B:S279 3.0625409
102B:B:R283 4.78699
103B:B:G288 1.8325437
104B:B:Y289 6.0225417
105B:B:N295 5.215416
106B:B:V296 3.49254215
107B:B:W297 2.938518
108B:B:K301 3.4975405
109B:B:H311 7.025439
110B:B:N313 2.71437
111B:B:R314 9.27438
112B:B:L318 2.51506
113B:B:T321 3.444127
114B:B:D323 5.074127
115B:B:M325 4.55254125
116B:B:T329 3.098538
117B:B:S331 4.682539
118B:B:W332 9.544539
119B:B:D333 5.835439
120B:B:K337 3.998536
121B:B:I338 2.03585
122B:B:W339 8.4975439
123B:B:N340 4.665409
124G:G:D48 5.25509
125G:G:L51 3.045496
126G:G:V54 3.95754246
127G:G:F61 4.17488
128R:R:L46 5.8525405
129R:R:T47 2.24455
130R:R:Y50 4.6845257
131R:R:M74 3.5825407
132R:R:F92 8.268576
133R:R:M93 2.465266
134R:R:L96 4.048507
135R:R:W108 6.245658
136R:R:P109 6.82454
137R:R:I114 3.695456
138R:R:V118 3.235455
139R:R:D122 4.7475476
140R:R:I124 2.18754305
141R:R:N125 4.395407
142R:R:Q126 6.142577
143R:R:T128 3.9565307
144R:R:Y141 5.8275408
145R:R:P147 4.16254108
146R:R:I148 2.81754105
147R:R:R154 3.0654185
148R:R:S170 2.72254307
149R:R:L183 4.14314
150R:R:I223 2.6975406
151R:R:Y228 4.825409
152R:R:V262 1.5425407
153R:R:W269 4.954578
154R:R:N308 3.80254299
155R:R:Y312 5.2754299
156R:R:F319 5.4854288
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:L69 20.47134.07NoNo085
2B:B:L69 B:B:Y105 20.91592.34NoYes056
3B:B:V71 B:B:Y105 14.42436.31YesYes086
4B:B:H54 B:B:S74 20.92244.18YesYes099
5B:B:D76 B:B:S74 30.86688.83YesYes399
6B:B:A73 B:B:L79 14.39141.58NoYes097
7B:B:A73 B:B:V100 21.99761.7NoNo099
8B:B:C114 B:B:V100 21.97333.42YesNo2289
9B:B:C114 B:B:G115 57.47881.96YesNo089
10B:B:G115 B:B:T102 57.71111.82NoNo098
11B:B:C149 B:B:T102 57.82931.69YesNo088
12B:B:C149 B:B:T159 50.42791.69YesYes289
13B:B:L146 B:B:T159 54.78792.95NoYes079
14B:B:L146 B:B:S161 61.16813NoYes079
15B:B:G162 B:B:S161 70.46971.86NoYes299
16B:B:G162 B:B:Y145 55.14884.35NoNo298
17B:B:L117 B:B:Y145 1002.34NoNo098
18B:B:L117 B:B:W99 99.9213.42NoYes099
19A:A:I207 B:B:W99 97.41413.52NoYes099
20A:A:I207 A:A:V224 97.32653.07NoNo099
21A:A:V224 A:A:W234 97.063414.71NoNo099
22A:A:R231 A:A:W234 97.34265YesNo099
23A:A:I276 A:A:R231 97.55112.51NoYes089
24A:A:F246 A:A:I276 97.45772.51NoNo098
25A:A:F246 A:A:V248 97.36242.62NoNo097
26A:A:L289 A:A:V248 96.42441.49YesNo1497
27A:A:C359 A:A:L289 91.32571.59NoYes059
28A:A:C359 A:A:S349 91.21163.44NoYes057
29A:A:S349 A:A:V346 89.6711.62YesNo074
30A:A:P361 A:A:V346 89.55781.77NoNo054
31A:A:P361 A:A:Y360 90.79721.39NoYes058
32A:A:D381 A:A:Y360 84.27684.6NoYes088
33A:A:D381 A:A:Q385 83.95431.31NoNo085
34A:A:L384 A:A:Q385 83.79231.33NoNo065
35A:A:L384 A:A:L388 83.46692.77NoYes068
36A:A:L388 R:R:V144 82.64462.98YesNo088
37R:R:I231 R:R:V144 82.47861.54NoNo098
38R:R:I231 R:R:Y141 82.14523.63NoYes098
39R:R:V145 R:R:Y141 17.26928.83NoYes078
40R:R:H146 R:R:V145 16.96934.15NoNo057
41A:A:H362 A:A:Y360 14.36682.18NoYes1198
42A:A:H362 A:A:R374 14.06944.51NoYes1194
43A:A:N371 A:A:R374 11.85652.41YesYes094
44B:B:D186 B:B:G162 15.41881.68YesNo299
45B:B:Q75 B:B:S74 10.96092.89NoYes399
46B:B:D83 B:B:R68 16.831311.91NoYes085
47B:B:R68 B:B:Y85 14.561820.58YesYes854
48B:B:Y85 G:G:P60 18.56295.56YesNo049
49B:B:M325 G:G:P60 15.64915.03YesNo059
50B:B:M325 G:G:P49 11.51273.35YesNo057
51G:G:D48 G:G:P49 12.9574.83YesNo097
52G:G:D48 G:G:L51 10.25756.79YesYes096
53B:B:I37 B:B:R283 17.05873.76YesYes929
54B:B:I37 B:B:T34 17.75271.52YesNo925
55B:B:L30 B:B:T34 18.5568.84NoNo055
56B:B:L30 B:B:M262 19.06425.65NoNo054
57B:B:M262 B:B:Y264 19.32033.59NoYes045
58B:B:N239 B:B:R256 17.51573.62NoNo029
59B:B:D254 B:B:R256 14.79761.19YesNo099
60B:B:A257 B:B:D254 12.49934.63NoYes079
61B:B:A257 B:B:Q259 11.57913.03NoYes2076
62B:B:C250 B:B:Y264 12.99374.03NoYes085
63B:B:C250 B:B:I273 13.0111.64NoYes186
64B:B:G244 B:B:I273 19.04761.76NoYes056
65B:B:G244 B:B:T243 19.31221.82NoYes058
66B:B:I232 B:B:T243 24.47133.04YesYes188
67B:B:I232 B:B:S189 46.51426.19YesNo087
68B:B:G202 B:B:S189 46.79411.86NoNo067
69B:B:G202 B:B:S201 47.09773.71NoYes069
70B:B:D186 B:B:G185 57.941.68YesNo095
71B:B:G185 B:B:T184 57.66163.64NoNo053
72B:B:D205 B:B:T184 57.53582.89NoNo093
73B:B:A203 B:B:D205 57.18353.09NoNo089
74B:B:A203 B:B:H183 29.42994.39NoYes489
75B:B:H183 B:B:S201 25.09674.18YesYes499
76B:B:A203 B:B:V187 27.65253.39NoYes489
77B:B:S201 B:B:V187 24.80413.23YesYes499
78B:B:D76 B:B:G77 29.93521.68YesNo098
79B:B:G77 B:B:L95 29.9573.42NoYes088
80B:B:F151 B:B:I157 19.44728.79YesYes297
81B:B:F151 B:B:Y111 16.57752.06YesYes094
82B:B:I123 B:B:Y111 10.80913.63NoYes064
83B:B:I232 B:B:S191 18.29691.55YesNo188
84B:B:F234 B:B:G238 18.08843.01YesNo157
85R:R:C227 R:R:Y141 68.15316.72NoYes078
86R:R:C227 R:R:I223 60.21771.64NoYes076
87R:R:I223 R:R:T134 59.0664.56YesNo067
88R:R:I130 R:R:T134 58.59261.52NoNo787
89R:R:I130 R:R:W269 58.51445.87NoYes788
90R:R:Q126 R:R:W269 53.53298.76YesYes778
91R:R:F92 R:R:Q126 25.744612.88YesYes767
92R:R:F92 R:R:Y302 19.774612.38YesNo767
93R:R:L96 R:R:Y302 38.882911.72YesNo077
94R:R:L96 R:R:Y50 36.98072.34YesYes077
95R:R:D295 R:R:Y50 34.21036.9NoYes027
96R:R:D295 R:R:L46 33.654819NoYes025
97R:R:D122 R:R:Q126 19.3893.92YesYes767
98R:R:D122 R:R:Y302 19.6515.75YesNo767
99R:R:L46 R:R:V103 30.86951.49YesNo054
100R:R:N43 R:R:V103 14.86944.43NoNo534
101R:R:T47 R:R:V103 15.44131.59YesNo554
102R:R:A104 R:R:N43 14.30374.69NoNo553
103R:R:A104 R:R:T47 14.30991.68NoYes555
104R:R:A104 R:R:L105 27.47523.15NoNo555
105R:R:L105 R:R:P109 24.0463.28NoYes554
106R:R:P109 R:R:W108 21.76534.05YesYes548
107B:B:C114 B:B:L95 32.44953.17YesYes2288
108B:B:F234 B:B:S191 18.07473.96YesNo158
109B:B:G238 B:B:N239 13.95821.7NoNo172
110B:B:D186 B:B:Y145 44.92952.3YesNo298
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y27
Class A
SubFamily Peptide
Type Somatostatin
SubType SST2
Species Homo Sapiens
Ligand Somatostatin-14
Other Ligand(s) -
Protein Partners chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.48
Date 2022-10-19
D.O.I. doi.org/10.1038/s41589-022-01130-3
Net Summary
Imin 1.49
Number of Linked Nodes 824
Number of Links 984
Number of Hubs 156
Number of Links mediated by Hubs 552
Number of Communities 33
Number of Nodes involved in Communities 230
Number of Links involved in Communities 305
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 740866
Length Of Smallest Path 3
Average Path Length 33.3034
Length of Longest Path 74
Minimum Path Strength 1.165
Average Path Strength 3.97664
Maximum Path Strength 17.68
Minimum Path Correlation 0.71
Average Path Correlation 0.984936
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 52.4159
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.303
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • somatostatin receptor activity   • neuropeptide receptor activity   • binding   • neuropeptide binding   • peptide binding   • protein binding   • PDZ domain binding   • protein domain specific binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of cell population proliferation   • negative regulation of cellular process   • negative regulation of biological process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to lipid   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • cellular response to lipid   • response to estradiol   • cellular response to estradiol stimulus   • response to endogenous stimulus   • response to glucocorticoid   • cellular response to glucocorticoid stimulus   • cellular response to corticosteroid stimulus   • cellular response to endogenous stimulus   • response to corticosteroid   • response to hormone   • response to steroid hormone   • cellular response to steroid hormone stimulus   • cellular response to hormone stimulus   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • G-protein beta-subunit binding   • fibroblast proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to prostaglandin E   • cellular response to ketone   • hormone activity   • molecular function activator activity   • signaling receptor binding   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • response to acid chemical   • response to amino acid   • response to xenobiotic stimulus   • regulation of postsynaptic membrane neurotransmitter receptor levels   • regulation of biological quality   • somatostatin signaling pathway   • hormone-mediated signaling pathway   • somatostatin receptor signaling pathway   • cell-cell signaling   • regulation of cell motility   • regulation of locomotion   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • response to osmotic stress   • hyperosmotic response   • response to stress   • response to abiotic stimulus   • cell surface receptor signaling pathway   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cell death   • apoptotic signaling pathway   • hormone-mediated apoptotic signaling pathway   • apoptotic process   • programmed cell death   • response to nutrient levels   • response to nutrient   • response to pH   • response to acidic pH   • multicellular organismal process   • digestion   • dense core granule   • intracellular vesicle   • endomembrane system   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • neuronal dense core vesicle   • GABA-ergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDPN
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeDPN
NameD-Phenylalanine
SynonymsD-Phenylalanine
Identifier
FormulaC9 H11 N O2
Molecular Weight165.189
SMILES
PubChem71567
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds23
Total Aromatic Bonds6

CodeDTR
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeDTR
NameD-Tryptophan
Synonyms
  • D-Tryptophan
  • (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
  • (R)-tryptophan
  • DTR
Identifier
FormulaC11 H12 N2 O2
Molecular Weight204.225
SMILES
PubChem6923517
Formal Charge0
Total Atoms27
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7Y27_Chain_A
TVSAEDKAA AERSKMIDK NLREDGEKA RRTLRLLLL GADNSGKST 
IVKQMRIGI FETKFQVDK VNFHMFDVG GQRDERRKW IQCFNDVTA 
IIFVVDSSD YNRLQEALN DFKSIWNNR WLRTISVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDPR VTRAKYFIR KEFVDISTA 
SGDGRHICY PHFTCAVDT ENARRIFND CKDIILQMN LREYNLVED 
ATPEPG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7Y27_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7Y27_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30874
Sequence
>7Y27_Chain_R
LTSNAVLTF IYFVVCIIG LCGNTLVIY VILRYAKMK TITNIYILN 
LAIADELFM LGLPFLAMQ VALVHWPFG KAICRVVMT VDGINQFTS 
IFCLTVMSI DRYLAVVHP IKSAKWRRP RTAKMITMA VWGVSLLVI 
LPIMIYAGL RSNQWGRSS CTINWGAWY TGFIIYTFI LGFLVPLTI 
ICLCYLFII IKVKSSKKS EKKVTRMVS IVVAVFIFC WLPFYIFNV 
SSVSMPTPA LKGMFDFVV VLTYANSCA NPILYAFLS DNFKKSFQN 
VPAIS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XATAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAT (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAUAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ22.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAU (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAVAPeptideSomatostatinSST2Homo sapiensLanreotide-Gi1/β1/γ22.872022-08-31doi.org/10.1038/s41421-022-00405-2
7XAV (No Gprot) APeptideSomatostatinSST2Homo sapiensLanreotide-2.872022-08-31doi.org/10.1038/s41421-022-00405-2
7WICAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIC (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIGAPeptideSomatostatinSST2Homo sapiensL-054,264-Gi1/β1/γ22.72022-06-01doi.org/10.1038/s41422-022-00669-z
7WIG (No Gprot) APeptideSomatostatinSST2Homo sapiensL-054,264-2.72022-06-01doi.org/10.1038/s41422-022-00669-z
7XMRAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XMR (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XN9APeptideSomatostatinSST2Homo sapiensL-054,522--2.62022-08-03doi.org/10.1038/s41422-022-00679-x
7XNAAPeptideSomatostatinSST2Homo sapiensCYN154806--2.652022-08-03doi.org/10.1038/s41422-022-00679-x
7YACAPeptideSomatostatinSST2Homo sapiensPaltusotine-Gi1/β1/γ23.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAC (No Gprot) APeptideSomatostatinSST2Homo sapiensPaltusotine-3.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAEAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ23.372023-04-19doi.org/10.1038/s41467-023-36673-z
7YAE (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.372023-04-19doi.org/10.1038/s41467-023-36673-z
7Y24APeptideSomatostatinSST2Homo sapiensOctreotide-Go/β1/γ23.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y24 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26APeptideSomatostatinSST2Homo sapiensOctreotide-chim(NtGi2L-Gs-CtGq)/β1/γ23.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27APeptideSomatostatinSST2Homo sapiensSomatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ23.482022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.482022-10-19doi.org/10.1038/s41589-022-01130-3
7UL5APeptideSomatostatinSST2Homo sapiens---3.12022-06-29doi.org/10.1038/s41594-022-00859-8
7WJ5APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.722022-07-13doi.org/10.7554/eLife.76823
7WJ5 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.722022-07-13doi.org/10.7554/eLife.76823
7T10APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi3/β1/γ22.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T10 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T11APeptideSomatostatinSST2Homo sapiensOctreotide-Gi3/β1/γ22.72022-03-09doi.org/10.1038/s41594-022-00727-5
7T11 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.72022-03-09doi.org/10.1038/s41594-022-00727-5




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