psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C14	L:L:C3	7.28	No	No	4	0	0
2	L:L:C3	R:R:R184	5.57	No	Yes	4	0	2
3	L:L:K4	R:R:Y205	14.33	No	No	0	0	4
4	L:L:K4	R:R:S279	3.06	No	No	0	0	4
5	L:L:F6	L:L:N5	3.62	Yes	No	5	0	0
6	L:L:N5	R:R:P286	8.15	No	No	5	0	2
7	L:L:F11	L:L:F6	8.57	No	Yes	0	0	0
8	L:L:F6	R:R:S279	5.28	Yes	No	0	0	4
9	L:L:F6	R:R:P286	2.89	Yes	No	5	0	2
10	L:L:F6	R:R:L290	7.31	Yes	Yes	0	0	4
11	L:L:F6	R:R:F294	12.86	Yes	Yes	0	0	4
12	L:L:F7	L:L:W8	3.01	Yes	Yes	1	0	0
13	L:L:F7	R:R:W197	4.01	Yes	Yes	1	0	5
14	L:L:F7	R:R:Y205	16.5	Yes	No	1	0	4
15	L:L:F7	R:R:F208	5.36	Yes	Yes	1	0	7
16	L:L:K9	L:L:W8	10.44	Yes	Yes	1	0	0
17	L:L:W8	R:R:Q126	6.57	Yes	Yes	1	0	7
18	L:L:W8	R:R:I177	3.52	Yes	No	1	0	3
19	L:L:W8	R:R:F208	7.02	Yes	Yes	1	0	7
20	L:L:W8	R:R:T212	3.64	Yes	Yes	1	0	4
21	L:L:W8	R:R:F272	5.01	Yes	Yes	0	0	6
22	L:L:K9	R:R:F92	4.96	Yes	Yes	1	0	6
23	L:L:K9	R:R:D122	12.44	Yes	Yes	1	0	6
24	L:L:K9	R:R:Q126	6.78	Yes	Yes	1	0	7
25	L:L:K9	R:R:V298	3.04	Yes	No	0	0	6
26	L:L:K9	R:R:Y302	9.55	Yes	Yes	1	0	7
27	L:L:T10	R:R:T194	3.14	No	No	0	0	4
28	L:L:T12	R:R:S192	3.2	No	No	0	0	4
29	L:L:T12	R:R:T194	4.71	No	No	0	0	4
30	L:L:C14	R:R:R184	4.18	No	Yes	4	0	2
31	R:R:N43	R:R:T47	5.85	No	Yes	0	3	5
32	R:R:D295	R:R:L46	16.29	Yes	No	0	2	5
33	R:R:F48	R:R:F51	4.29	No	No	0	6	5
34	R:R:I49	R:R:V299	4.61	No	No	0	5	5
35	R:R:L96	R:R:Y50	8.21	Yes	Yes	0	7	7
36	R:R:D295	R:R:Y50	3.45	Yes	Yes	0	2	7
37	R:R:V298	R:R:Y50	7.57	No	Yes	0	6	7
38	R:R:V299	R:R:Y50	8.83	No	Yes	0	5	7
39	R:R:A100	R:R:F51	4.16	No	No	0	6	5
40	R:R:L96	R:R:V53	2.98	Yes	No	0	7	7
41	R:R:V299	R:R:V53	4.81	No	No	0	5	7
42	R:R:C54	R:R:I55	4.91	Yes	No	0	6	4
43	R:R:C54	R:R:M93	3.24	Yes	Yes	1	6	6
44	R:R:C54	R:R:L96	3.17	Yes	Yes	1	6	7
45	R:R:C54	R:R:P97	3.77	Yes	No	1	6	8
46	R:R:C306	R:R:I56	3.27	No	No	0	8	4
47	R:R:G57	R:R:M93	3.49	No	Yes	0	8	6
48	R:R:C306	R:R:G57	3.92	No	No	0	8	8
49	R:R:E90	R:R:L58	3.98	No	No	0	7	6
50	R:R:L58	R:R:M93	5.65	No	Yes	0	6	6
51	R:R:L58	R:R:L94	4.15	No	No	0	6	5
52	R:R:C59	R:R:G60	3.92	No	No	0	5	8
53	R:R:G60	R:R:L63	3.42	No	No	0	8	6
54	R:R:D89	R:R:N61	8.08	Yes	No	7	9	9
55	R:R:E90	R:R:N61	6.57	No	No	0	7	9
56	R:R:N61	R:R:P309	11.4	No	No	7	9	9
57	R:R:E90	R:R:T62	7.06	No	No	0	7	5
58	R:R:I68	R:R:V64	3.07	Yes	No	0	7	9
59	R:R:I65	R:R:L69	2.85	Yes	No	0	7	3
60	R:R:I65	R:R:L83	2.85	Yes	No	8	7	6
61	R:R:A86	R:R:I65	3.25	No	Yes	0	9	7
62	R:R:I65	R:R:I87	2.94	Yes	No	8	7	7
63	R:R:F319	R:R:V67	6.55	No	No	0	8	7
64	R:R:I68	R:R:M74	5.83	Yes	No	0	7	7
65	R:R:I68	R:R:I82	2.94	Yes	No	0	7	8
66	R:R:I68	R:R:L83	7.14	Yes	No	0	7	6
67	R:R:F319	R:R:I68	5.02	No	Yes	0	8	7
68	R:R:S322	R:R:Y71	16.53	No	No	0	5	6
69	R:R:M74	R:R:N79	18.23	No	No	0	7	8
70	R:R:N79	R:R:T76	10.24	No	No	0	8	7
71	R:R:I77	R:R:Y81	4.84	No	Yes	0	4	7
72	R:R:I82	R:R:T78	3.04	No	No	0	8	8
73	R:R:M136	R:R:Y81	5.99	No	Yes	0	9	7
74	R:R:D139	R:R:Y81	8.05	No	Yes	0	8	7
75	R:R:I82	R:R:M136	2.92	No	No	0	8	9
76	R:R:I87	R:R:L83	2.85	No	No	8	7	6
77	R:R:N84	R:R:T163	11.7	No	No	0	9	7
78	R:R:C132	R:R:L85	7.94	No	No	0	8	9
79	R:R:L133	R:R:L85	4.15	No	No	0	9	9
80	R:R:A88	R:R:T128	3.36	No	Yes	0	8	7
81	R:R:D89	R:R:S129	4.42	Yes	No	0	9	9
82	R:R:D89	R:R:S305	10.31	Yes	No	0	9	8
83	R:R:D89	R:R:P309	3.22	Yes	No	7	9	9
84	R:R:L91	R:R:N125	10.98	No	No	0	7	7
85	R:R:D122	R:R:F92	9.55	Yes	Yes	1	6	6
86	R:R:F92	R:R:N125	6.04	Yes	No	0	6	7
87	R:R:F92	R:R:Q126	3.51	Yes	Yes	1	6	7
88	R:R:F92	R:R:Y302	25.79	Yes	Yes	1	6	7
89	R:R:L96	R:R:M93	4.24	Yes	Yes	1	7	6
90	R:R:M93	R:R:Y302	3.59	Yes	Yes	1	6	7
91	R:R:L96	R:R:P97	4.93	Yes	No	1	7	8
92	R:R:L96	R:R:Y302	12.89	Yes	Yes	1	7	7
93	R:R:F98	R:R:W108	3.01	No	Yes	2	5	8
94	R:R:F98	R:R:V118	5.24	No	No	2	5	5
95	R:R:L99	R:R:Y302	3.52	No	Yes	0	6	7
96	R:R:F110	R:R:M101	3.73	Yes	No	0	6	5
97	R:R:Q102	R:R:V103	2.87	No	No	0	5	4
98	R:R:Q102	R:R:W108	4.38	No	Yes	0	5	8
99	R:R:Q102	R:R:S192	2.89	No	No	0	5	4
100	R:R:H107	R:R:L105	10.29	No	No	9	4	5
101	R:R:L105	R:R:P109	3.28	No	No	9	5	4
102	R:R:H107	R:R:P109	9.15	No	No	9	4	4
103	R:R:F110	R:R:W108	26.06	Yes	Yes	0	6	8
104	R:R:C115	R:R:W108	5.22	Yes	Yes	2	9	8
105	R:R:V118	R:R:W108	6.13	No	Yes	2	5	8
106	R:R:L183	R:R:W108	6.83	No	Yes	2	4	8
107	R:R:C193	R:R:W108	10.45	No	Yes	2	9	8
108	R:R:F110	R:R:P109	4.33	Yes	No	0	6	4
109	R:R:F110	R:R:I114	5.02	Yes	No	0	6	6
110	R:R:K112	R:R:R116	4.95	No	No	0	3	6
111	R:R:C115	R:R:L183	3.17	Yes	No	2	9	4
112	R:R:C115	R:R:C193	7.28	Yes	No	2	9	9
113	R:R:A181	R:R:M119	3.22	No	No	0	4	5
114	R:R:C193	R:R:M119	4.86	No	No	0	9	5
115	R:R:M178	R:R:T120	6.02	No	No	0	5	6
116	R:R:I124	R:R:V121	3.07	Yes	No	0	5	5
117	R:R:N125	R:R:V121	5.91	No	No	0	7	5
118	R:R:D122	R:R:G123	3.35	Yes	No	0	6	4
119	R:R:D122	R:R:Y302	6.9	Yes	Yes	1	6	7
120	R:R:G123	R:R:I174	3.53	No	No	0	4	7
121	R:R:I124	R:R:T128	3.04	Yes	Yes	3	5	7
122	R:R:I124	R:R:W167	3.52	Yes	No	3	5	9
123	R:R:I124	R:R:S170	6.19	Yes	No	3	5	7
124	R:R:F127	R:R:Q126	8.2	Yes	Yes	0	6	7
125	R:R:Q126	R:R:W269	10.95	Yes	Yes	1	7	8
126	R:R:F127	R:R:F131	3.22	Yes	No	0	6	6
127	R:R:F127	R:R:V173	6.55	Yes	Yes	0	6	4
128	R:R:F127	R:R:G216	3.01	Yes	No	0	6	6
129	R:R:T128	R:R:W167	18.19	Yes	No	3	7	9
130	R:R:S170	R:R:T128	6.4	No	Yes	3	7	7
131	R:R:I130	R:R:P220	6.77	No	Yes	0	8	9
132	R:R:F265	R:R:I130	3.77	Yes	No	0	9	8
133	R:R:L133	R:R:N308	9.61	No	No	0	9	9
134	R:R:P220	R:R:T134	3.5	Yes	No	0	9	7
135	R:R:I223	R:R:T134	4.56	No	No	0	6	7
136	R:R:V135	R:R:V166	3.21	No	No	0	7	6
137	R:R:M136	R:R:Y312	4.79	No	No	0	9	9
138	R:R:I224	R:R:S137	12.39	No	No	0	7	9
139	R:R:S137	R:R:Y228	6.36	No	No	0	9	9
140	R:R:C227	R:R:I138	4.91	No	No	0	7	6
141	R:R:D139	R:R:R154	10.72	No	No	0	8	5
142	R:R:R140	R:R:Y228	9.26	No	No	0	9	9
143	R:R:I231	R:R:R140	3.76	No	No	0	9	9
144	R:R:L142	R:R:Y141	3.52	No	Yes	0	4	8
145	R:R:V145	R:R:Y141	11.36	No	Yes	10	7	8
146	R:R:H146	R:R:Y141	4.36	No	Yes	10	5	8
147	R:R:F230	R:R:Y141	6.19	No	Yes	0	4	8
148	R:R:A143	R:R:R154	6.91	No	No	0	8	5
149	R:R:I231	R:R:V144	3.07	No	No	0	9	8
150	R:R:H146	R:R:V145	5.54	No	No	10	5	7
151	R:R:K234	R:R:V145	3.04	No	No	0	5	7
152	R:R:R154	R:R:S150	3.95	No	No	0	5	5
153	R:R:M164	R:R:T163	3.01	No	No	0	4	7
154	R:R:V173	R:R:Y211	3.79	Yes	No	0	4	4
155	R:R:I174	R:R:I177	2.94	No	No	0	7	3
156	R:R:P176	R:R:W197	5.4	No	Yes	1	8	5
157	R:R:F208	R:R:P176	2.89	Yes	No	1	7	8
158	R:R:F208	R:R:I177	6.28	Yes	No	1	7	3
159	R:R:I179	R:R:Y180	6.04	No	No	0	4	4
160	R:R:W197	R:R:Y180	8.68	Yes	No	0	5	4
161	R:R:P198	R:R:Y180	18.08	No	No	0	5	4
162	R:R:L183	R:R:S191	7.51	No	No	0	4	5
163	R:R:R184	R:R:T194	3.88	Yes	No	0	2	4
164	R:R:N196	R:R:R184	8.44	No	Yes	0	3	2
165	R:R:S185	R:R:S191	6.52	No	No	0	2	5
166	R:R:N186	R:R:R190	6.03	Yes	No	0	1	1
167	R:R:Q187	R:R:W188	10.95	No	No	0	2	2
168	R:R:I195	R:R:W197	10.57	No	Yes	0	5	5
169	R:R:W197	R:R:W204	13.12	Yes	No	0	5	3
170	R:R:W197	R:R:Y205	7.72	Yes	No	1	5	4
171	R:R:F208	R:R:W197	13.03	Yes	Yes	1	7	5
172	R:R:T206	R:R:V280	3.17	No	No	0	3	4
173	R:R:F208	R:R:T212	5.19	Yes	Yes	1	7	4
174	R:R:I209	R:R:T212	3.04	No	Yes	0	5	4
175	R:R:I209	R:R:V280	4.61	No	No	0	5	4
176	R:R:I210	R:R:I214	2.94	No	No	0	5	4
177	R:R:T212	R:R:Y273	3.75	Yes	Yes	1	4	7
178	R:R:F213	R:R:F217	6.43	No	Yes	1	5	8
179	R:R:F213	R:R:Y273	9.28	No	Yes	1	5	7
180	R:R:I214	R:R:L215	2.85	No	No	0	4	4
181	R:R:G216	R:R:P220	4.06	No	Yes	0	6	9
182	R:R:F217	R:R:F265	3.22	Yes	Yes	1	8	9
183	R:R:F217	R:R:W269	3.01	Yes	Yes	1	8	8
184	R:R:F217	R:R:L270	6.09	Yes	Yes	0	8	5
185	R:R:F217	R:R:Y273	5.16	Yes	Yes	1	8	7
186	R:R:P220	R:R:V219	3.53	Yes	No	0	9	5
187	R:R:I223	R:R:V219	3.07	No	No	0	6	5
188	R:R:C225	R:R:L221	3.17	No	No	0	5	6
189	R:R:F265	R:R:L221	4.87	Yes	No	0	9	6
190	R:R:I266	R:R:L221	8.56	No	No	0	6	6
191	R:R:V258	R:R:Y228	16.4	No	No	0	8	9
192	R:R:I232	R:R:V254	3.07	No	No	0	5	8
193	R:R:I232	R:R:T255	6.08	No	No	0	5	7
194	R:R:E251	R:R:V235	2.85	No	No	0	6	8
195	R:R:E251	R:R:K236	8.1	No	No	0	6	4
196	R:R:G239	R:R:R247	6	No	No	0	5	4
197	R:R:K246	R:R:R241	7.43	No	No	0	3	1
198	R:R:G243	R:R:K246	3.49	No	No	0	1	3
199	R:R:K249	R:R:S245	4.59	No	No	0	4	2
200	R:R:E251	R:R:S250	10.06	No	No	0	6	5
201	R:R:D317	R:R:K253	4.15	No	No	0	5	7
202	R:R:I260	R:R:R256	3.76	No	No	0	6	6
203	R:R:L315	R:R:M257	7.07	No	No	0	6	8
204	R:R:L311	R:R:V261	4.47	No	No	0	8	8
205	R:R:I266	R:R:V262	3.07	No	No	0	6	7
206	R:R:F265	R:R:W269	8.02	Yes	Yes	1	9	8
207	R:R:I266	R:R:L270	2.85	No	Yes	0	6	5
208	R:R:C268	R:R:N304	7.87	No	No	0	8	9
209	R:R:W269	R:R:Y273	5.79	Yes	Yes	1	8	7
210	R:R:T301	R:R:W269	10.92	No	Yes	0	7	8
211	R:R:N304	R:R:W269	9.04	No	Yes	0	9	8
212	R:R:L270	R:R:P271	3.28	Yes	No	0	5	9
213	R:R:I274	R:R:L270	7.14	No	Yes	0	5	5
214	R:R:P271	R:R:V297	3.53	No	No	0	9	7
215	R:R:F272	R:R:Y273	7.22	Yes	Yes	0	6	7
216	R:R:F272	R:R:N276	13.29	Yes	No	0	6	6
217	R:R:F272	R:R:V297	3.93	Yes	No	0	6	7
218	R:R:F275	R:R:L290	3.65	Yes	Yes	0	4	4
219	R:R:F275	R:R:M293	8.71	Yes	No	0	4	4
220	R:R:F275	R:R:F294	9.65	Yes	Yes	0	4	4
221	R:R:F275	R:R:V297	3.93	Yes	No	0	4	7
222	R:R:F294	R:R:N276	3.62	Yes	No	0	4	6
223	R:R:I284	R:R:L290	2.85	No	Yes	0	1	4
224	R:R:P288	R:R:T287	3.5	No	No	0	3	1
225	R:R:L290	R:R:T287	4.42	Yes	No	0	4	1
226	R:R:G292	R:R:K291	3.49	No	No	6	1	3
227	R:R:D295	R:R:K291	5.53	Yes	No	6	2	3
228	R:R:D295	R:R:G292	5.03	Yes	No	6	2	1
229	R:R:F294	R:R:V298	3.93	Yes	No	0	4	6
230	R:R:F296	R:R:L300	10.96	No	No	0	5	7
231	R:R:N304	R:R:N308	4.09	No	No	0	9	9
232	R:R:N308	R:R:Y312	5.81	No	No	0	9	9
233	R:R:F319	R:R:S316	5.28	No	No	0	8	8
234	R:R:L171	R:R:M178	2.83	No	No	0	3	5
235	R:R:L175	R:R:M178	2.83	No	No	0	4	5
236	R:R:A181	R:R:R116	2.77	No	No	0	4	6
237	R:R:C227	R:R:Y141	2.69	No	Yes	0	7	8
238	R:R:A100	R:R:Y50	2.67	No	Yes	0	6	7
239	R:R:A159	R:R:Y81	2.67	No	Yes	0	7	7
240	R:R:F131	R:R:V166	2.62	No	No	0	6	6
241	R:R:R155	R:R:T158	2.59	No	No	0	6	5
242	R:R:V67	R:R:Y71	2.52	No	No	0	7	6
243	R:R:T163	R:R:Y81	2.5	No	Yes	0	7	7
244	R:R:I231	R:R:Y141	2.42	No	Yes	0	9	8
245	L:L:W8	R:R:M119	2.33	Yes	No	0	0	5
246	R:R:N186	R:R:W188	2.26	Yes	No	0	1	2
247	R:R:R140	R:R:Y312	2.06	No	No	0	9	9
248	R:R:C115	R:R:G182	1.96	Yes	No	0	9	5
249	R:R:G202	R:R:S201	1.86	No	No	0	2	2
250	R:R:G207	R:R:T206	1.82	No	No	0	4	3
251	R:R:P286	R:R:S285	1.78	No	No	0	2	2
252	R:R:G207	R:R:I210	1.76	No	No	0	4	5
253	L:L:K4	R:R:G202	1.74	No	No	0	0	2
254	R:R:A203	R:R:S201	1.71	No	No	0	1	2
255	R:R:C268	R:R:V264	1.71	No	No	0	8	7
256	R:R:A303	R:R:V53	1.7	No	No	0	5	7
257	R:R:G189	R:R:N186	1.7	No	Yes	0	6	1
258	R:R:A307	R:R:V264	1.7	No	No	0	6	7
259	R:R:I148	R:R:P147	1.69	No	No	0	5	8
260	R:R:A44	R:R:T47	1.68	No	Yes	0	4	5
261	R:R:A104	R:R:T47	1.68	No	Yes	0	5	5
262	R:R:A289	R:R:T287	1.68	No	No	0	1	1
263	R:R:L175	R:R:P176	1.64	No	No	0	4	8
264	R:R:L300	R:R:P271	1.64	No	No	0	7	9
265	R:R:S244	R:R:S245	1.63	No	No	0	3	2
266	R:R:A159	R:R:I80	1.62	No	No	0	7	5
267	R:R:S281	R:R:V277	1.62	No	No	0	4	5
268	R:R:S281	R:R:V280	1.62	No	No	0	4	4
269	R:R:V144	R:R:V235	1.6	No	No	0	8	8
270	R:R:V169	R:R:V173	1.6	No	Yes	0	4	4
271	R:R:T47	R:R:V103	1.59	Yes	No	0	5	4
272	R:R:I162	R:R:V135	1.54	No	No	0	5	7
273	R:R:K291	R:R:S42	1.53	No	No	0	3	4
274	R:R:H146	R:R:P147	1.53	No	No	0	5	8
275	R:R:K248	R:R:S245	1.53	No	No	0	3	2
276	R:R:K246	R:R:S250	1.53	No	No	0	3	5
277	R:R:K236	R:R:T255	1.5	No	No	0	4	7
278	L:L:S13	R:R:N186	1.49	No	Yes	0	0	1
279	R:R:L63	R:R:V64	1.49	No	No	0	6	9
280	R:R:L172	R:R:V173	1.49	No	Yes	0	3	4
281	R:R:L311	R:R:V264	1.49	No	No	0	8	7
282	R:R:N43	R:R:V106	1.48	No	No	0	3	4
283	R:R:L226	R:R:T222	1.47	No	No	0	5	4
284	R:R:I284	R:R:M282	1.46	No	No	0	1	3
285	R:R:I80	R:R:K160	1.45	No	No	0	5	1
286	R:R:K73	R:R:M74	1.44	No	No	0	5	7
287	R:R:P156	R:R:R155	1.44	No	No	0	3	6
288	R:R:I260	R:R:L311	1.43	No	No	0	6	8
289	R:R:C268	R:R:F267	1.4	No	No	0	8	6
290	R:R:L226	R:R:L229	1.38	No	No	0	5	4
291	R:R:D317	R:R:N318	1.35	No	No	0	5	5
292	R:R:F275	R:R:S278	1.32	Yes	No	0	4	4
293	R:R:R190	R:R:V106	1.31	No	No	0	1	4
294	R:R:F230	R:R:I233	1.26	No	No	0	4	3
295	R:R:F314	R:R:I310	1.26	No	No	0	7	6
296	R:R:K248	R:R:R247	1.24	No	No	0	3	4
297	R:R:R70	R:R:Y71	1.03	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F6	6.755	6	5	0
2	L:L:F7	7.22	4	1	0
3	L:L:W8	5.1925	8	1	0
4	L:L:K9	7.86833	6	1	0
5	R:R:T47	2.7	4	0	5
6	R:R:Y50	6.146	5	0	7
7	R:R:C54	3.7725	4	1	6
8	R:R:I65	2.9725	4	8	7
9	R:R:I68	4.8	5	0	7
10	R:R:Y81	4.81	5	0	7
11	R:R:D89	6.5075	4	7	9
12	R:R:F92	9.97	5	1	6
13	R:R:M93	4.042	5	1	6
14	R:R:L96	6.07	6	1	7
15	R:R:W108	8.86857	7	2	8
16	R:R:F110	9.785	4	0	6
17	R:R:C115	4.4075	4	2	9
18	R:R:D122	8.06	4	1	6
19	R:R:I124	3.955	4	3	5
20	R:R:Q126	7.202	5	1	7
21	R:R:F127	5.245	4	0	6
22	R:R:T128	7.7475	4	3	7
23	R:R:Y141	5.09	6	10	8
24	R:R:V173	3.3575	4	0	4
25	R:R:R184	5.5175	4	4	2
26	R:R:N186	2.87	4	0	1
27	R:R:W197	8.93286	7	1	5
28	R:R:F208	6.62833	6	1	7
29	R:R:T212	3.905	4	1	4
30	R:R:F217	4.782	5	1	8
31	R:R:P220	4.465	4	0	9
32	R:R:F265	4.97	4	1	9
33	R:R:W269	7.955	6	1	8
34	R:R:L270	4.84	4	0	5
35	R:R:F272	7.3625	4	0	6
36	R:R:Y273	6.24	5	1	7
37	R:R:F275	5.452	5	0	4
38	R:R:L290	4.5575	4	0	4
39	R:R:F294	7.515	4	0	4
40	R:R:D295	7.575	4	6	2
41	R:R:Y302	10.3733	6	1	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:T12	R:R:S192	11.3153	3.2	No	No	0	0	4
2	R:R:Q102	R:R:S192	12.8862	2.89	No	No	0	5	4
3	R:R:Q102	R:R:W108	32.2532	4.38	No	Yes	0	5	8
4	R:R:C193	R:R:W108	48.003	10.45	No	Yes	2	9	8
5	R:R:C193	R:R:M119	56.4257	4.86	No	No	0	9	5
6	L:L:W8	R:R:M119	61.0863	2.33	Yes	No	0	0	5
7	L:L:F7	L:L:W8	16.2773	3.01	Yes	Yes	1	0	0
8	L:L:K9	L:L:W8	25.2333	10.44	Yes	Yes	1	0	0
9	L:L:K9	R:R:V298	25.2043	3.04	Yes	No	0	0	6
10	R:R:F294	R:R:V298	16.8106	3.93	Yes	No	0	4	6
11	L:L:F6	R:R:F294	16.1788	12.86	Yes	Yes	0	0	4
12	L:L:W8	R:R:F272	14.9093	5.01	Yes	Yes	0	0	6
13	R:R:F272	R:R:V297	15.2107	3.93	Yes	No	0	6	7
14	R:R:F275	R:R:V297	12.7297	3.93	Yes	No	0	4	7
15	R:R:F275	R:R:L290	10.6313	3.65	Yes	Yes	0	4	4
16	L:L:W8	R:R:F208	14.5789	7.02	Yes	Yes	1	0	7
17	R:R:F208	R:R:W197	11.5588	13.03	Yes	Yes	1	7	5
18	L:L:W8	R:R:Q126	49.0928	6.57	Yes	Yes	1	0	7
19	L:L:W8	R:R:T212	11.3675	3.64	Yes	Yes	1	0	4
20	R:R:F92	R:R:Q126	26.0043	3.51	Yes	Yes	1	6	7
21	L:L:K9	R:R:Y302	28.3984	9.55	Yes	Yes	1	0	7
22	R:R:Q102	R:R:V103	19.054	2.87	No	No	0	5	4
23	R:R:T47	R:R:V103	17.5294	1.59	Yes	No	0	5	4
24	R:R:N43	R:R:T47	12.8862	5.85	No	Yes	0	3	5
25	R:R:V298	R:R:Y50	18.7178	7.57	No	Yes	0	6	7
26	R:R:L96	R:R:Y302	12.2138	12.89	Yes	Yes	1	7	7
27	R:R:M93	R:R:Y302	29.7896	3.59	Yes	Yes	1	6	7
28	R:R:L58	R:R:M93	20.5495	5.65	No	Yes	0	6	6
29	R:R:E90	R:R:L58	16.0628	3.98	No	No	0	7	6
30	R:R:Q126	R:R:W269	83.9893	10.95	Yes	Yes	1	7	8
31	R:R:N304	R:R:W269	100	9.04	No	Yes	0	9	8
32	R:R:N304	R:R:N308	91.8439	4.09	No	No	0	9	9
33	R:R:N308	R:R:Y312	87.879	5.81	No	No	0	9	9
34	R:R:M136	R:R:Y312	53.9273	4.79	No	No	0	9	9
35	R:R:I82	R:R:M136	35.5747	2.92	No	No	0	8	9
36	R:R:I68	R:R:I82	32.6532	2.94	Yes	No	0	7	8
37	R:R:E90	R:R:N61	11.5298	6.57	No	No	0	7	9
38	R:R:F319	R:R:I68	10.2951	5.02	No	Yes	0	8	7
39	R:R:M136	R:R:Y81	20.109	5.99	No	Yes	0	9	7
40	R:R:F92	R:R:N125	16.5961	6.04	Yes	No	0	6	7
41	R:R:N125	R:R:V121	12.5152	5.91	No	No	0	7	5
42	R:R:I124	R:R:V121	10.4574	3.07	Yes	No	0	5	5
43	R:R:F127	R:R:Q126	21.8712	8.2	Yes	Yes	0	6	7
44	R:R:F265	R:R:W269	11.7674	8.02	Yes	Yes	1	9	8
45	R:R:R140	R:R:Y312	44.1018	2.06	No	No	0	9	9
46	R:R:I231	R:R:R140	37.0993	3.76	No	No	0	9	9
47	R:R:I231	R:R:Y141	18.6134	2.42	No	Yes	0	9	8
48	R:R:I231	R:R:V144	18.3815	3.07	No	No	0	9	8
49	R:R:N43	R:R:V106	11.3153	1.48	No	No	0	3	4
50	R:R:I209	R:R:T212	16.1672	3.04	No	Yes	0	5	4
51	R:R:I209	R:R:V280	14.4166	4.61	No	No	0	5	4
52	R:R:T212	R:R:Y273	16.9381	3.75	Yes	Yes	1	4	7
53	R:R:F272	R:R:Y273	14.2369	7.22	Yes	Yes	0	6	7
54	R:R:F217	R:R:L270	10.9269	6.09	Yes	Yes	0	8	5
55	R:R:V144	R:R:V235	16.7353	1.6	No	No	0	8	8
56	R:R:E251	R:R:V235	15.0832	2.85	No	No	0	6	8
57	R:R:C268	R:R:N304	13.5876	7.87	No	No	0	8	9
58	R:R:C268	R:R:V264	10.2371	1.71	No	No	0	8	7
59	L:L:K9	R:R:Q126	29.2041	6.78	Yes	Yes	1	0	7
60	R:R:W269	R:R:Y273	21.9408	5.79	Yes	Yes	1	8	7
61	R:R:F92	R:R:Y302	16.3411	25.79	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C3	R:R:R184	5.57	4	No	Yes	0	2	0	1
L:L:K4	R:R:Y205	14.33	0	No	No	0	4	0	1
L:L:K4	R:R:S279	3.06	0	No	No	0	4	0	1
L:L:N5	R:R:P286	8.15	5	No	No	0	2	0	1
L:L:F6	R:R:S279	5.28	5	Yes	No	0	4	0	1
L:L:F6	R:R:P286	2.89	5	Yes	No	0	2	0	1
L:L:F6	R:R:L290	7.31	5	Yes	Yes	0	4	0	1
L:L:F6	R:R:F294	12.86	5	Yes	Yes	0	4	0	1
L:L:F7	R:R:W197	4.01	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:Y205	16.5	1	Yes	No	0	4	0	1
L:L:F7	R:R:F208	5.36	1	Yes	Yes	0	7	0	1
L:L:W8	R:R:Q126	6.57	1	Yes	Yes	0	7	0	1
L:L:W8	R:R:I177	3.52	1	Yes	No	0	3	0	1
L:L:W8	R:R:F208	7.02	1	Yes	Yes	0	7	0	1
L:L:W8	R:R:T212	3.64	1	Yes	Yes	0	4	0	1
L:L:W8	R:R:F272	5.01	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:F92	4.96	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:D122	12.44	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:Q126	6.78	1	Yes	Yes	0	7	0	1
L:L:K9	R:R:V298	3.04	1	Yes	No	0	6	0	1
L:L:K9	R:R:Y302	9.55	1	Yes	Yes	0	7	0	1
L:L:T10	R:R:T194	3.14	0	No	No	0	4	0	1
L:L:T12	R:R:S192	3.2	0	No	No	0	4	0	1
L:L:T12	R:R:T194	4.71	0	No	No	0	4	0	1
L:L:C14	R:R:R184	4.18	4	No	Yes	0	2	0	1
R:R:L96	R:R:Y50	8.21	1	Yes	Yes	7	7	2	2
R:R:V298	R:R:Y50	7.57	0	No	Yes	6	7	1	2
R:R:D122	R:R:F92	9.55	1	Yes	Yes	6	6	1	1
R:R:F92	R:R:N125	6.04	1	Yes	No	6	7	1	2
R:R:F92	R:R:Q126	3.51	1	Yes	Yes	6	7	1	1
R:R:F92	R:R:Y302	25.79	1	Yes	Yes	6	7	1	1
R:R:L96	R:R:M93	4.24	1	Yes	Yes	7	6	2	2
R:R:M93	R:R:Y302	3.59	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	12.89	1	Yes	Yes	7	7	2	1
R:R:L99	R:R:Y302	3.52	0	No	Yes	6	7	2	1
R:R:Q102	R:R:S192	2.89	0	No	No	5	4	2	1
R:R:A181	R:R:M119	3.22	0	No	No	4	5	2	1
R:R:C193	R:R:M119	4.86	2	No	No	9	5	2	1
R:R:D122	R:R:G123	3.35	1	Yes	No	6	4	1	2
R:R:D122	R:R:Y302	6.9	1	Yes	Yes	6	7	1	1
R:R:G123	R:R:I174	3.53	0	No	No	4	7	2	2
R:R:F127	R:R:Q126	8.2	0	Yes	Yes	6	7	2	1
R:R:Q126	R:R:W269	10.95	1	Yes	Yes	7	8	1	2
R:R:I174	R:R:I177	2.94	0	No	No	7	3	2	1
R:R:P176	R:R:W197	5.4	1	No	Yes	8	5	2	1
R:R:F208	R:R:P176	2.89	1	Yes	No	7	8	1	2
R:R:F208	R:R:I177	6.28	1	Yes	No	7	3	1	1
R:R:W197	R:R:Y180	8.68	1	Yes	No	5	4	1	2
R:R:R184	R:R:T194	3.88	4	Yes	No	2	4	1	1
R:R:N196	R:R:R184	8.44	0	No	Yes	3	2	2	1
R:R:N186	R:R:R190	6.03	0	Yes	No	1	1	1	2
R:R:I195	R:R:W197	10.57	0	No	Yes	5	5	2	1
R:R:W197	R:R:W204	13.12	1	Yes	No	5	3	1	2
R:R:W197	R:R:Y205	7.72	1	Yes	No	5	4	1	1
R:R:F208	R:R:W197	13.03	1	Yes	Yes	7	5	1	1
R:R:F208	R:R:T212	5.19	1	Yes	Yes	7	4	1	1
R:R:I209	R:R:T212	3.04	0	No	Yes	5	4	2	1
R:R:T212	R:R:Y273	3.75	1	Yes	Yes	4	7	1	2
R:R:W269	R:R:Y273	5.79	1	Yes	Yes	8	7	2	2
R:R:F272	R:R:Y273	7.22	0	Yes	Yes	6	7	1	2
R:R:F272	R:R:N276	13.29	0	Yes	No	6	6	1	2
R:R:F272	R:R:V297	3.93	0	Yes	No	6	7	1	2
R:R:F275	R:R:L290	3.65	0	Yes	Yes	4	4	2	1
R:R:F275	R:R:F294	9.65	0	Yes	Yes	4	4	2	1
R:R:F275	R:R:V297	3.93	0	Yes	No	4	7	2	2
R:R:F294	R:R:N276	3.62	0	Yes	No	4	6	1	2
R:R:I284	R:R:L290	2.85	0	No	Yes	1	4	2	1
R:R:L290	R:R:T287	4.42	0	Yes	No	4	1	1	2
R:R:F294	R:R:V298	3.93	0	Yes	No	4	6	1	1
L:L:W8	R:R:M119	2.33	1	Yes	No	0	5	0	1
R:R:N186	R:R:W188	2.26	0	Yes	No	1	2	1	2
R:R:G202	R:R:S201	1.86	0	No	No	2	2	1	2
R:R:P286	R:R:S285	1.78	5	No	No	2	2	1	2
L:L:K4	R:R:G202	1.74	0	No	No	0	2	0	1
R:R:G189	R:R:N186	1.7	0	No	Yes	6	1	2	1
L:L:S13	R:R:N186	1.49	0	No	Yes	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WJ5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	262
Number of Links	297
Number of Hubs	41
Number of Links mediated by Hubs	154
Number of Communities	10
Number of Nodes involved in Communities	53
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	41001
Length Of Smallest Path	3
Average Path Length	10.9562
Length of Longest Path	27
Minimum Path Strength	1.385
Average Path Strength	5.77879
Maximum Path Strength	19.34
Minimum Path Correlation	0.7
Average Path Correlation	0.929983
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	57.8623
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6861
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • neuropeptide binding • peptide binding • PDZ domain binding • protein domain specific binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • neuropeptide signaling pathway • head development • forebrain development • brain development • nervous system development • central nervous system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to estradiol • cellular response to estradiol stimulus • cerebellum development • metencephalon development • hindbrain development • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • response to corticosteroid • response to steroid hormone • cellular response to steroid hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • metabolic process • generation of precursor metabolites and energy • periplasmic space • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • response to acid chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • regulation of biological quality • somatostatin signaling pathway • hormone-mediated signaling pathway • somatostatin receptor signaling pathway • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • response to osmotic stress • hyperosmotic response • response to abiotic stimulus • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient • response to pH • response to acidic pH • digestion • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • GABA-ergic synapse • somatodendritic compartment • cell body • neuronal cell body
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7WJ5_nogp_Chain_R T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

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Download 7WJ5_nogp.zip

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