Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:F6 5.188540
2L:L:W8 4.65833610
3L:L:K9 6.22460
4L:L:F11 4.555440
5L:L:T12 3.47450
6R:R:Y50 7.355407
7R:R:I65 3.26254107
8R:R:Y71 7.4275476
9R:R:Y81 4.36571737
10R:R:L83 3.53254106
11R:R:D89 5.884509
12R:R:F92 7.29667666
13R:R:M93 2.9875406
14R:R:L96 6.185407
15R:R:W108 8.65833688
16R:R:F110 7.582586
17R:R:M119 2.4475415
18R:R:N125 5.9375407
19R:R:F127 3.29333606
20R:R:T134 3.535427
21R:R:Y141 6.8465118
22R:R:R154 7.5725435
23R:R:W167 4.515439
24R:R:I177 3.97413
25R:R:R184 4.64452
26R:R:W197 8.19667615
27R:R:Y205 7.15504
28R:R:F208 6.3125417
29R:R:I209 2.8025405
30R:R:F217 3.336518
31R:R:L221 3.44416
32R:R:I223 3.0225426
33R:R:Y228 3.356529
34R:R:L251 2.915406
35R:R:V258 2.7425428
36R:R:F265 2.69519
37R:R:W269 5.102518
38R:R:F272 6.406506
39R:R:Y273 5.99517
40R:R:K291 6.13403
41R:R:Y302 7.80333667
42R:R:N304 4.225419
43R:R:Y312 3.50714719
44R:R:F314 3.87407
45R:R:V326 5.4575475
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F7 R:R:Y205 12.824310.32NoYes004
2L:L:F7 L:L:W8 15.67913.01NoYes000
3L:L:W8 R:R:M119 1002.33YesYes105
4R:R:C193 R:R:M119 97.83321.62NoYes095
5R:R:C115 R:R:C193 43.82927.28NoNo099
6R:R:C115 R:R:W108 41.78369.14NoYes098
7R:R:Q102 R:R:W108 46.24457.67NoYes058
8R:R:Q102 R:R:S192 42.06087.22NoNo054
9L:L:T12 R:R:S192 37.8733.2YesNo004
10R:R:C193 R:R:L183 52.17613.17NoNo094
11R:R:L183 R:R:W108 41.94795.69NoYes048
12L:L:T12 R:R:R184 16.8562.59YesYes502
13L:L:W8 R:R:F272 82.0765.01YesYes006
14R:R:F272 R:R:V298 32.25572.62YesNo066
15R:R:F294 R:R:V298 37.32885.24NoNo046
16L:L:F6 R:R:F294 31.126111.79YesNo404
17L:L:F11 L:L:F6 14.26812.14YesYes400
18L:L:F6 R:R:S279 11.16883.96YesNo004
19R:R:F208 R:R:W197 10.30837.02YesYes175
20L:L:W8 R:R:T212 37.74576.06YesNo104
21R:R:F208 R:R:T212 11.00045.19YesNo174
22L:L:K9 R:R:V298 19.72114.55YesNo006
23L:L:K9 R:R:F92 18.44152.48YesYes606
24R:R:F272 R:R:T301 50.7243.89YesNo067
25R:R:T301 R:R:Y302 20.37636.24NoYes077
26R:R:F92 R:R:Y302 18.11712.38YesYes667
27R:R:M93 R:R:Y302 12.12592.39YesYes067
28R:R:L96 R:R:Y302 14.29078.21YesYes077
29R:R:L96 R:R:Y50 10.016611.72YesYes077
30R:R:T212 R:R:Y273 49.3132.5NoYes147
31R:R:W269 R:R:Y273 75.70295.79YesYes187
32R:R:N304 R:R:W269 65.66374.52YesYes198
33R:R:N304 R:R:N308 64.19936.81YesNo099
34R:R:D89 R:R:N308 28.5656.73YesNo099
35R:R:F272 R:R:Y273 58.16927.22YesYes067
36R:R:T301 R:R:W269 49.47322.43NoYes078
37R:R:F92 R:R:S305 31.73822.64YesNo068
38R:R:D89 R:R:S305 31.62328.83YesNo098
39R:R:D89 R:R:N61 34.26246.73YesNo099
40R:R:N61 R:R:P309 26.78024.89NoNo099
41R:R:P309 R:R:V64 25.48013.53NoNo099
42R:R:F314 R:R:V64 22.86142.62YesNo079
43R:R:F314 R:R:F319 17.58515.36YesNo078
44R:R:F319 R:R:F323 10.90398.57NoNo086
45R:R:F217 R:R:Y273 32.44263.09YesYes187
46R:R:F217 R:R:F265 31.23092.14YesYes189
47R:R:F265 R:R:L133 81.12922.44YesNo199
48R:R:L133 R:R:Y312 78.70364.69NoYes199
49R:R:M136 R:R:Y312 73.9884.79NoYes099
50R:R:M136 R:R:Y81 72.03484.79NoYes097
51R:R:I162 R:R:Y81 32.09974.84NoYes057
52R:R:I162 R:R:T158 27.97961.52NoNo055
53R:R:R155 R:R:T158 25.85183.88NoNo065
54R:R:P156 R:R:R155 21.58391.44NoNo036
55R:R:I80 R:R:P156 19.44381.69NoNo053
56R:R:I80 R:R:M74 15.15131.46NoNo057
57R:R:K73 R:R:M74 12.99881.44NoNo057
58R:R:F265 R:R:W269 51.73454.01YesYes198
59R:R:N308 R:R:Y312 64.38625.81NoYes099
60R:R:K73 R:R:K75 10.84237.18NoNo057
61R:R:I77 R:R:Y81 17.04493.63NoYes347
62R:R:D139 R:R:Y81 17.1645.75NoYes387
63R:R:I77 R:R:R154 14.9135.01NoYes345
64R:R:D139 R:R:R154 15.036313.1NoYes385
65R:R:Q126 R:R:W269 14.6078.76NoYes078
66R:R:F127 R:R:Q126 16.69787.03YesNo067
67R:R:F98 R:R:W108 12.64155.01NoYes858
68R:R:F110 R:R:W108 12.629119.04YesYes868
69R:R:R140 R:R:Y312 83.20772.06NoYes099
70R:R:R140 R:R:Y228 81.25653.09NoYes099
71R:R:I224 R:R:Y228 19.85052.42NoYes279
72R:R:I224 R:R:T134 17.67753.04NoYes277
73R:R:I231 R:R:Y228 43.57452.42NoYes099
74R:R:I231 R:R:Y141 24.23962.42NoYes098
75R:R:V145 R:R:Y141 13.257612.62NoYes1178
76R:R:R154 R:R:S150 21.50185.27YesNo055
77R:R:S150 R:R:W153 12.91262.47NoNo053
78R:R:I209 R:R:N276 12.39092.83YesNo056
79R:R:V258 R:R:Y228 15.35466.31YesYes289
80R:R:K234 R:R:V145 11.07851.52NoNo057
81R:R:I231 R:R:V235 17.54811.54NoNo098
82R:R:L251 R:R:V235 15.35052.98YesNo068
83R:R:F272 R:R:N276 13.84513.29YesNo066
84R:R:D89 R:R:L85 15.562.71YesNo099
85R:R:L85 R:R:Y312 14.69942.34NoYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:A1 R:R:E200 3.02 0 No No 0 4 0 1
L:L:G2 R:R:E200 4.91 0 No No 0 4 0 1
L:L:C3 R:R:R184 8.36 5 No Yes 0 2 0 1
L:L:K4 R:R:Y205 14.33 0 No Yes 0 4 0 1
L:L:K4 R:R:V280 3.04 0 No No 0 4 0 1
L:L:N5 R:R:P286 6.52 4 No No 0 2 0 1
L:L:F6 R:R:F275 3.22 4 Yes No 0 4 0 1
L:L:F6 R:R:S279 3.96 4 Yes No 0 4 0 1
L:L:F6 R:R:F294 11.79 4 Yes No 0 4 0 1
L:L:F7 R:R:Y205 10.32 0 No Yes 0 4 0 1
L:L:F7 R:R:I209 3.77 0 No Yes 0 5 0 1
L:L:W8 R:R:M119 2.33 1 Yes Yes 0 5 0 1
L:L:W8 R:R:I177 3.52 1 Yes Yes 0 3 0 1
L:L:W8 R:R:F208 8.02 1 Yes Yes 0 7 0 1
L:L:W8 R:R:T212 6.06 1 Yes No 0 4 0 1
L:L:W8 R:R:F272 5.01 1 Yes Yes 0 6 0 1
L:L:K9 R:R:F92 2.48 6 Yes Yes 0 6 0 1
L:L:K9 R:R:D122 8.3 6 Yes No 0 6 0 1
L:L:K9 R:R:V298 4.55 6 Yes No 0 6 0 1
L:L:K9 R:R:Y302 9.55 6 Yes Yes 0 7 0 1
L:L:T10 R:R:T194 3.14 0 No No 0 4 0 1
L:L:F11 R:R:K291 9.93 4 Yes Yes 0 3 0 1
L:L:T12 R:R:R184 2.59 5 Yes Yes 0 2 0 1
L:L:T12 R:R:S192 3.2 5 Yes No 0 4 0 1
L:L:T12 R:R:T194 4.71 5 Yes No 0 4 0 1
L:L:S13 R:R:V106 3.23 0 No No 0 4 0 1
L:L:C14 R:R:R184 2.79 5 No Yes 0 2 0 1
R:R:K291 R:R:N43 2.8 0 Yes No 3 3 1 2
R:R:D122 R:R:F92 10.75 6 No Yes 6 6 1 1
R:R:F92 R:R:N125 9.67 6 Yes Yes 6 7 1 2
R:R:F92 R:R:Q126 5.86 6 Yes No 6 7 1 2
R:R:F92 R:R:Y302 12.38 6 Yes Yes 6 7 1 1
R:R:F92 R:R:S305 2.64 6 Yes No 6 8 1 2
R:R:M93 R:R:Y302 2.39 0 Yes Yes 6 7 2 1
R:R:L96 R:R:Y302 8.21 0 Yes Yes 7 7 2 1
R:R:Q102 R:R:S192 7.22 0 No No 5 4 2 1
R:R:I177 R:R:M119 2.92 1 Yes Yes 3 5 1 1
R:R:I195 R:R:M119 2.92 1 No Yes 5 5 2 1
R:R:D122 R:R:Y302 8.05 6 No Yes 6 7 1 1
R:R:I177 R:R:I195 4.42 1 Yes No 3 5 1 2
R:R:F208 R:R:I177 5.02 1 Yes Yes 7 3 1 1
R:R:N196 R:R:R184 4.82 0 No Yes 3 2 2 1
R:R:I195 R:R:W197 12.92 1 No Yes 5 5 2 2
R:R:W197 R:R:Y205 6.75 1 Yes Yes 5 4 2 1
R:R:F208 R:R:W197 7.02 1 Yes Yes 7 5 1 2
R:R:G202 R:R:Y205 2.9 0 No Yes 2 4 2 1
R:R:T206 R:R:V280 3.17 0 No No 3 4 2 1
R:R:F208 R:R:T212 5.19 1 Yes No 7 4 1 1
R:R:I209 R:R:N276 2.83 0 Yes No 5 6 1 2
R:R:I209 R:R:V280 3.07 0 Yes No 5 4 1 1
R:R:T212 R:R:Y273 2.5 1 No Yes 4 7 1 2
R:R:F272 R:R:Y273 7.22 0 Yes Yes 6 7 1 2
R:R:F272 R:R:N276 13.29 0 Yes No 6 6 1 2
R:R:F272 R:R:V298 2.62 0 Yes No 6 6 1 1
R:R:F272 R:R:T301 3.89 0 Yes No 6 7 1 2
R:R:F275 R:R:M293 3.73 4 No No 4 4 1 2
R:R:F275 R:R:F294 9.65 4 No No 4 4 1 1
R:R:G292 R:R:K291 3.49 0 No Yes 1 3 2 1
R:R:D295 R:R:K291 8.3 9 No Yes 2 3 2 1
R:R:F294 R:R:V298 5.24 4 No No 4 6 1 1
R:R:T301 R:R:Y302 6.24 0 No Yes 7 7 2 1
R:R:P286 R:R:S285 1.78 0 No No 2 2 1 2
R:R:C193 R:R:M119 1.62 0 No Yes 9 5 2 1
R:R:I284 R:R:S279 1.55 0 No No 1 4 2 1
R:R:I209 R:R:V277 1.54 0 Yes No 5 5 1 2
L:L:G2 R:R:Y205 1.45 0 No Yes 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7T10_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.06
Number of Linked Nodes 280
Number of Links 319
Number of Hubs 45
Number of Links mediated by Hubs 177
Number of Communities 11
Number of Nodes involved in Communities 66
Number of Links involved in Communities 87
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 120176
Length Of Smallest Path 3
Average Path Length 14.8611
Length of Longest Path 31
Minimum Path Strength 1.265
Average Path Strength 4.63672
Maximum Path Strength 14.425
Minimum Path Correlation 0.7
Average Path Correlation 0.92238
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5.26316
Average % Of Corr. Nodes 42.7883
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.8205
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP30874
Sequence
>7T10_nogp_Chain_R
LTSNAVLTF IYFVVCIIG LCGNTLVIY VILRYAKMK TITNIYILN 
LAIADELFM LGLPFLAMQ VALVHWPFG KAICRVVMT VDGINQFTS 
IFCLTVMSI DRYLAVVHP IKSAKWRRP RTAKMITMA VWGVSLLVI 
LPIMIYAGL RSNQGRSSC TINWPGESG AWYTGFIIY TFILGFLVP 
LTIICLCYL FIIIKVKSG SKVTRMVSI VVAVFIFCW LPFYIFNVS 
SVSMAISPT PALKGMFDF VVVLTYANS CANPILYAF LSDNFKKSF 
QNVLVRLLS REKDRNLR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XATAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAT (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAUAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ22.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAU (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAVAPeptideSomatostatinSST2Homo sapiensLanreotide-Gi1/β1/γ22.872022-08-31doi.org/10.1038/s41421-022-00405-2
7XAV (No Gprot) APeptideSomatostatinSST2Homo sapiensLanreotide-2.872022-08-31doi.org/10.1038/s41421-022-00405-2
7WICAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIC (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIGAPeptideSomatostatinSST2Homo sapiensL-054,264-Gi1/β1/γ22.72022-06-01doi.org/10.1038/s41422-022-00669-z
7WIG (No Gprot) APeptideSomatostatinSST2Homo sapiensL-054,264-2.72022-06-01doi.org/10.1038/s41422-022-00669-z
7XMRAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XMR (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XN9APeptideSomatostatinSST2Homo sapiensL-054,522--2.62022-08-03doi.org/10.1038/s41422-022-00679-x
7XNAAPeptideSomatostatinSST2Homo sapiensCYN154806--2.652022-08-03doi.org/10.1038/s41422-022-00679-x
7YACAPeptideSomatostatinSST2Homo sapiensPaltusotine-Gi1/β1/γ23.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAC (No Gprot) APeptideSomatostatinSST2Homo sapiensPaltusotine-3.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAEAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ23.372023-04-19doi.org/10.1038/s41467-023-36673-z
7YAE (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.372023-04-19doi.org/10.1038/s41467-023-36673-z
7Y24APeptideSomatostatinSST2Homo sapiensOctreotide-Go/β1/γ23.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y24 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26APeptideSomatostatinSST2Homo sapiensOctreotide-chim(NtGi2L-Gs-CtGq)/β1/γ23.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27APeptideSomatostatinSST2Homo sapiensSomatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ23.482022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.482022-10-19doi.org/10.1038/s41589-022-01130-3
7UL5APeptideSomatostatinSST2Homo sapiens---3.12022-06-29doi.org/10.1038/s41594-022-00859-8
7WJ5APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.722022-07-13doi.org/10.7554/eLife.76823
7WJ5 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.722022-07-13doi.org/10.7554/eLife.76823
7T10APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi3/β1/γ22.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T10 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T11APeptideSomatostatinSST2Homo sapiensOctreotide-Gi3/β1/γ22.72022-03-09doi.org/10.1038/s41594-022-00727-5
7T11 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.72022-03-09doi.org/10.1038/s41594-022-00727-5




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Download 7T10_nogp.zip



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