psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A1	R:R:E200	3.02	No	No	0	0	4
2	L:L:G2	R:R:E200	4.91	No	No	0	0	4
3	L:L:C3	L:L:T12	3.38	No	Yes	5	0	0
4	L:L:C14	L:L:C3	7.28	No	No	5	0	0
5	L:L:C3	R:R:R184	8.36	No	Yes	5	0	2
6	L:L:K4	R:R:Y205	14.33	No	Yes	0	0	4
7	L:L:K4	R:R:V280	3.04	No	No	0	0	4
8	L:L:F6	L:L:N5	4.83	Yes	No	4	0	0
9	L:L:F11	L:L:N5	4.83	Yes	No	4	0	0
10	L:L:N5	R:R:P286	6.52	No	No	0	0	2
11	L:L:F11	L:L:F6	2.14	Yes	Yes	4	0	0
12	L:L:F6	R:R:F275	3.22	Yes	No	4	0	4
13	L:L:F6	R:R:S279	3.96	Yes	No	0	0	4
14	L:L:F6	R:R:F294	11.79	Yes	No	4	0	4
15	L:L:F7	L:L:W8	3.01	No	Yes	0	0	0
16	L:L:F7	R:R:Y205	10.32	No	Yes	0	0	4
17	L:L:F7	R:R:I209	3.77	No	Yes	0	0	5
18	L:L:W8	R:R:M119	2.33	Yes	Yes	1	0	5
19	L:L:W8	R:R:I177	3.52	Yes	Yes	1	0	3
20	L:L:W8	R:R:F208	8.02	Yes	Yes	1	0	7
21	L:L:W8	R:R:T212	6.06	Yes	No	1	0	4
22	L:L:W8	R:R:F272	5.01	Yes	Yes	0	0	6
23	L:L:K9	R:R:F92	2.48	Yes	Yes	6	0	6
24	L:L:K9	R:R:D122	8.3	Yes	No	6	0	6
25	L:L:K9	R:R:V298	4.55	Yes	No	0	0	6
26	L:L:K9	R:R:Y302	9.55	Yes	Yes	6	0	7
27	L:L:T10	R:R:T194	3.14	No	No	0	0	4
28	L:L:F11	R:R:K291	9.93	Yes	Yes	0	0	3
29	L:L:T12	R:R:R184	2.59	Yes	Yes	5	0	2
30	L:L:T12	R:R:S192	3.2	Yes	No	0	0	4
31	L:L:T12	R:R:T194	4.71	Yes	No	0	0	4
32	L:L:S13	R:R:V106	3.23	No	No	0	0	4
33	L:L:C14	R:R:R184	2.79	No	Yes	5	0	2
34	R:R:K291	R:R:N43	2.8	Yes	No	0	3	3
35	R:R:I49	R:R:V45	3.07	No	No	0	5	5
36	R:R:L46	R:R:V103	2.98	No	No	9	5	4
37	R:R:D295	R:R:L46	4.07	No	No	9	2	5
38	R:R:F51	R:R:T47	5.19	No	No	0	5	5
39	R:R:F48	R:R:V52	3.93	No	No	0	6	5
40	R:R:L96	R:R:Y50	11.72	Yes	Yes	0	7	7
41	R:R:L99	R:R:Y50	2.34	No	Yes	0	6	7
42	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
43	R:R:V299	R:R:Y50	11.36	No	Yes	0	5	7
44	R:R:A100	R:R:F51	2.77	No	No	0	6	5
45	R:R:I56	R:R:V52	3.07	No	No	0	4	5
46	R:R:C54	R:R:L58	3.17	No	No	0	6	6
47	R:R:C54	R:R:L96	3.17	No	Yes	0	6	7
48	R:R:G57	R:R:M93	3.49	No	Yes	0	8	6
49	R:R:L58	R:R:M93	2.83	No	Yes	0	6	6
50	R:R:L58	R:R:L94	5.54	No	No	0	6	5
51	R:R:D89	R:R:N61	6.73	Yes	No	0	9	9
52	R:R:E90	R:R:N61	3.94	No	No	0	7	9
53	R:R:N61	R:R:P309	4.89	No	No	0	9	9
54	R:R:E90	R:R:T62	5.64	No	No	0	7	5
55	R:R:P309	R:R:V64	3.53	No	No	0	9	9
56	R:R:A313	R:R:V64	3.39	No	No	0	7	9
57	R:R:F314	R:R:V64	2.62	Yes	No	0	7	9
58	R:R:I65	R:R:L69	2.85	Yes	No	10	7	3
59	R:R:I65	R:R:L83	2.85	Yes	Yes	10	7	6
60	R:R:A86	R:R:I65	3.25	No	Yes	0	9	7
61	R:R:E90	R:R:I65	4.1	No	Yes	0	7	7
62	R:R:R70	R:R:Y66	10.29	No	No	7	4	3
63	R:R:Y66	R:R:Y71	5.96	No	Yes	7	3	6
64	R:R:V326	R:R:Y66	5.05	Yes	No	7	5	3
65	R:R:F319	R:R:V67	9.18	No	No	0	8	7
66	R:R:I68	R:R:L83	4.28	No	Yes	0	7	6
67	R:R:L69	R:R:L83	4.15	No	Yes	10	3	6
68	R:R:R70	R:R:Y71	3.09	No	Yes	7	4	6
69	R:R:N325	R:R:Y71	9.3	No	Yes	0	4	6
70	R:R:V326	R:R:Y71	11.36	Yes	Yes	7	5	6
71	R:R:K73	R:R:K75	7.18	No	No	0	5	7
72	R:R:T76	R:R:T78	3.14	No	No	0	7	8
73	R:R:I77	R:R:Y81	3.63	No	Yes	3	4	7
74	R:R:D139	R:R:I77	4.2	No	No	3	8	4
75	R:R:I77	R:R:R154	5.01	No	Yes	3	4	5
76	R:R:I82	R:R:T78	3.04	No	No	0	8	8
77	R:R:V135	R:R:Y81	5.05	No	Yes	0	7	7
78	R:R:M136	R:R:Y81	4.79	No	Yes	0	9	7
79	R:R:D139	R:R:Y81	5.75	No	Yes	3	8	7
80	R:R:A159	R:R:Y81	4	No	Yes	0	7	7
81	R:R:I162	R:R:Y81	4.84	No	Yes	0	5	7
82	R:R:T163	R:R:Y81	2.5	No	Yes	3	7	7
83	R:R:I87	R:R:L83	2.85	No	Yes	0	7	6
84	R:R:N84	R:R:T163	10.24	No	No	3	9	7
85	R:R:N84	R:R:W167	4.52	No	Yes	3	9	9
86	R:R:D89	R:R:L85	2.71	Yes	No	0	9	9
87	R:R:L133	R:R:L85	4.15	No	No	1	9	9
88	R:R:L85	R:R:Y312	2.34	No	Yes	1	9	9
89	R:R:I87	R:R:L91	2.85	No	No	0	7	7
90	R:R:D89	R:R:S129	4.42	Yes	No	0	9	9
91	R:R:D89	R:R:S305	8.83	Yes	No	0	9	8
92	R:R:D89	R:R:N308	6.73	Yes	No	0	9	9
93	R:R:L91	R:R:N125	6.87	No	Yes	0	7	7
94	R:R:D122	R:R:F92	10.75	No	Yes	6	6	6
95	R:R:F92	R:R:N125	9.67	Yes	Yes	0	6	7
96	R:R:F92	R:R:Q126	5.86	Yes	No	0	6	7
97	R:R:F92	R:R:Y302	12.38	Yes	Yes	6	6	7
98	R:R:F92	R:R:S305	2.64	Yes	No	0	6	8
99	R:R:M93	R:R:Y302	2.39	Yes	Yes	0	6	7
100	R:R:C306	R:R:M93	3.24	No	Yes	0	8	6
101	R:R:L96	R:R:Y302	8.21	Yes	Yes	0	7	7
102	R:R:F98	R:R:W108	5.01	No	Yes	8	5	8
103	R:R:F110	R:R:F98	11.79	Yes	No	8	6	5
104	R:R:F98	R:R:V118	5.24	No	No	0	5	5
105	R:R:Q102	R:R:W108	7.67	No	Yes	0	5	8
106	R:R:Q102	R:R:S192	7.22	No	No	0	5	4
107	R:R:D295	R:R:V103	2.92	No	No	9	2	4
108	R:R:H107	R:R:R190	4.51	No	No	0	4	1
109	R:R:H107	R:R:S191	4.18	No	No	0	4	5
110	R:R:P109	R:R:W108	5.4	No	Yes	8	4	8
111	R:R:F110	R:R:W108	19.04	Yes	Yes	8	6	8
112	R:R:C115	R:R:W108	9.14	No	Yes	0	9	8
113	R:R:L183	R:R:W108	5.69	No	Yes	0	4	8
114	R:R:F110	R:R:P109	4.33	Yes	No	8	6	4
115	R:R:C115	R:R:C193	7.28	No	No	0	9	9
116	R:R:I177	R:R:M119	2.92	Yes	Yes	1	3	5
117	R:R:I195	R:R:M119	2.92	No	Yes	1	5	5
118	R:R:M178	R:R:T120	4.52	No	No	0	5	6
119	R:R:N125	R:R:V121	2.96	Yes	No	0	7	5
120	R:R:D122	R:R:Y302	8.05	No	Yes	6	6	7
121	R:R:I124	R:R:N125	4.25	No	Yes	0	5	7
122	R:R:I124	R:R:S170	4.64	No	No	0	5	7
123	R:R:F127	R:R:Q126	7.03	Yes	No	0	6	7
124	R:R:Q126	R:R:W269	8.76	No	Yes	0	7	8
125	R:R:F127	R:R:F131	2.14	Yes	No	0	6	6
126	R:R:F127	R:R:S170	2.64	Yes	No	0	6	7
127	R:R:F127	R:R:V173	3.93	Yes	No	0	6	4
128	R:R:F127	R:R:I174	2.51	Yes	No	0	6	7
129	R:R:T128	R:R:W167	9.7	No	Yes	0	7	9
130	R:R:S170	R:R:T128	6.4	No	No	0	7	7
131	R:R:I130	R:R:P220	3.39	No	No	0	8	9
132	R:R:F265	R:R:L133	2.44	Yes	No	1	9	9
133	R:R:L133	R:R:Y312	4.69	No	Yes	1	9	9
134	R:R:I138	R:R:T134	3.04	No	Yes	2	6	7
135	R:R:P220	R:R:T134	3.5	No	Yes	0	9	7
136	R:R:I223	R:R:T134	4.56	Yes	Yes	2	6	7
137	R:R:I224	R:R:T134	3.04	No	Yes	2	7	7
138	R:R:M136	R:R:Y312	4.79	No	Yes	0	9	9
139	R:R:I224	R:R:S137	3.1	No	No	2	7	9
140	R:R:S137	R:R:Y228	2.54	No	Yes	2	9	9
141	R:R:I138	R:R:I223	2.94	No	Yes	2	6	6
142	R:R:D139	R:R:R154	13.1	No	Yes	3	8	5
143	R:R:R140	R:R:Y228	3.09	No	Yes	0	9	9
144	R:R:R140	R:R:Y312	2.06	No	Yes	0	9	9
145	R:R:V145	R:R:Y141	12.62	No	Yes	11	7	8
146	R:R:H146	R:R:Y141	7.62	No	Yes	11	5	8
147	R:R:C227	R:R:Y141	5.38	No	Yes	0	7	8
148	R:R:F230	R:R:Y141	6.19	No	Yes	0	4	8
149	R:R:I231	R:R:Y141	2.42	No	Yes	0	9	8
150	R:R:A143	R:R:R154	6.91	No	Yes	0	8	5
151	R:R:H146	R:R:V145	11.07	No	No	11	5	7
152	R:R:K149	R:R:W153	3.48	No	No	0	4	3
153	R:R:S150	R:R:W153	2.47	No	No	0	5	3
154	R:R:R154	R:R:S150	5.27	Yes	No	0	5	5
155	R:R:K152	R:R:W153	3.48	No	No	0	4	3
156	R:R:R155	R:R:R157	18.13	No	No	0	6	4
157	R:R:R155	R:R:T158	3.88	No	No	0	6	5
158	R:R:T163	R:R:W167	2.43	No	Yes	3	7	9
159	R:R:V173	R:R:Y211	3.79	No	No	0	4	4
160	R:R:L175	R:R:M178	2.83	No	No	0	4	5
161	R:R:I177	R:R:I195	4.42	Yes	No	1	3	5
162	R:R:F208	R:R:I177	5.02	Yes	Yes	1	7	3
163	R:R:I179	R:R:Y180	8.46	No	No	0	4	4
164	R:R:W197	R:R:Y180	3.86	Yes	No	1	5	4
165	R:R:P198	R:R:Y180	2.78	No	No	1	5	4
166	R:R:L183	R:R:S191	6.01	No	No	0	4	5
167	R:R:C193	R:R:L183	3.17	No	No	0	9	4
168	R:R:N196	R:R:R184	4.82	No	Yes	0	3	2
169	R:R:S185	R:R:S191	6.52	No	No	0	2	5
170	R:R:G189	R:R:Q187	4.93	No	No	0	6	2
171	R:R:I195	R:R:W197	12.92	No	Yes	1	5	5
172	R:R:P198	R:R:W197	2.7	No	Yes	1	5	5
173	R:R:W197	R:R:W204	15.93	Yes	No	1	5	3
174	R:R:W197	R:R:Y205	6.75	Yes	Yes	0	5	4
175	R:R:F208	R:R:W197	7.02	Yes	Yes	1	7	5
176	R:R:P198	R:R:W204	2.7	No	No	1	5	3
177	R:R:S201	R:R:W204	3.71	No	No	0	2	3
178	R:R:G202	R:R:Y205	2.9	No	Yes	0	2	4
179	R:R:I210	R:R:T206	3.04	No	No	0	5	3
180	R:R:T206	R:R:V280	3.17	No	No	0	3	4
181	R:R:F208	R:R:T212	5.19	Yes	No	1	7	4
182	R:R:I209	R:R:N276	2.83	Yes	No	0	5	6
183	R:R:I209	R:R:V280	3.07	Yes	No	0	5	4
184	R:R:L215	R:R:Y211	5.86	No	No	0	4	4
185	R:R:T212	R:R:Y273	2.5	No	Yes	1	4	7
186	R:R:F213	R:R:F217	5.36	No	Yes	1	5	8
187	R:R:F213	R:R:L218	6.09	No	No	0	5	4
188	R:R:F213	R:R:Y273	11.35	No	Yes	1	5	7
189	R:R:F217	R:R:L221	2.44	Yes	Yes	1	8	6
190	R:R:F217	R:R:F265	2.14	Yes	Yes	1	8	9
191	R:R:F217	R:R:L270	3.65	Yes	No	0	8	5
192	R:R:F217	R:R:Y273	3.09	Yes	Yes	1	8	7
193	R:R:P220	R:R:V219	3.53	No	No	0	9	5
194	R:R:I223	R:R:V219	3.07	Yes	No	0	6	5
195	R:R:C225	R:R:L221	3.17	No	Yes	0	5	6
196	R:R:F265	R:R:L221	2.44	Yes	Yes	1	9	6
197	R:R:I266	R:R:L221	5.71	No	Yes	0	6	6
198	R:R:I224	R:R:Y228	2.42	No	Yes	2	7	9
199	R:R:I231	R:R:Y228	2.42	No	Yes	0	9	9
200	R:R:V258	R:R:Y228	6.31	Yes	Yes	2	8	9
201	R:R:K234	R:R:S237	4.59	No	No	0	5	5
202	R:R:L251	R:R:V235	2.98	Yes	No	0	6	8
203	R:R:K236	R:R:L251	2.82	No	Yes	0	4	6
204	R:R:L241	R:R:V238	10.43	No	No	0	1	5
205	R:R:L251	R:R:S242	4.5	Yes	No	0	6	3
206	R:R:G243	R:R:K247	3.49	No	No	0	1	4
207	R:R:K247	R:R:S244	10.71	No	No	0	4	3
208	R:R:R249	R:R:R252	10.66	No	No	0	4	5
209	R:R:K253	R:R:M257	5.76	No	No	0	7	8
210	R:R:V261	R:R:Y312	2.52	No	Yes	0	8	9
211	R:R:I266	R:R:V262	3.07	No	No	0	6	7
212	R:R:F265	R:R:W269	4.01	Yes	Yes	1	9	8
213	R:R:F265	R:R:N304	2.42	Yes	Yes	1	9	9
214	R:R:C268	R:R:N304	3.15	No	Yes	0	8	9
215	R:R:W269	R:R:Y273	5.79	Yes	Yes	1	8	7
216	R:R:T301	R:R:W269	2.43	No	Yes	0	7	8
217	R:R:N304	R:R:W269	4.52	Yes	Yes	1	9	8
218	R:R:I274	R:R:L270	5.71	No	No	0	5	5
219	R:R:F272	R:R:Y273	7.22	Yes	Yes	0	6	7
220	R:R:F272	R:R:N276	13.29	Yes	No	0	6	6
221	R:R:F272	R:R:V298	2.62	Yes	No	0	6	6
222	R:R:F272	R:R:T301	3.89	Yes	No	0	6	7
223	R:R:F275	R:R:M293	3.73	No	No	0	4	4
224	R:R:F275	R:R:F294	9.65	No	No	4	4	4
225	R:R:P288	R:R:T287	6.99	No	No	0	3	1
226	R:R:L290	R:R:T287	10.32	No	No	0	4	1
227	R:R:G292	R:R:K291	3.49	No	Yes	0	1	3
228	R:R:D295	R:R:K291	8.3	No	Yes	0	2	3
229	R:R:M293	R:R:V297	3.04	No	No	0	4	7
230	R:R:F294	R:R:V298	5.24	No	No	0	4	6
231	R:R:T301	R:R:Y302	6.24	No	Yes	0	7	7
232	R:R:N304	R:R:N308	6.81	Yes	No	0	9	9
233	R:R:N308	R:R:Y312	5.81	No	Yes	0	9	9
234	R:R:F314	R:R:I310	6.28	Yes	No	0	7	6
235	R:R:L311	R:R:Y312	2.34	No	Yes	0	8	9
236	R:R:F314	R:R:F319	5.36	Yes	No	0	7	8
237	R:R:N318	R:R:S316	4.47	No	No	0	5	8
238	R:R:D317	R:R:K320	2.77	No	No	0	5	8
239	R:R:F319	R:R:F323	8.57	No	No	0	8	6
240	R:R:F323	R:R:V326	3.93	No	Yes	0	6	5
241	R:R:G95	R:R:P97	2.03	No	No	0	6	8
242	R:R:C59	R:R:G60	1.96	No	No	0	5	8
243	R:R:G243	R:R:S242	1.86	No	No	0	1	3
244	R:R:G207	R:R:T206	1.82	No	No	0	4	3
245	R:R:A303	R:R:C268	1.81	No	No	0	5	8
246	R:R:P286	R:R:S285	1.78	No	No	0	2	2
247	R:R:G57	R:R:I56	1.76	No	No	0	8	4
248	R:R:G123	R:R:I174	1.76	No	No	0	4	7
249	R:R:C306	R:R:V53	1.71	No	No	0	8	7
250	R:R:A72	R:R:S322	1.71	No	No	0	5	5
251	R:R:A88	R:R:S129	1.71	No	No	0	8	9
252	R:R:C132	R:R:V166	1.71	No	No	0	8	6
253	R:R:A203	R:R:S201	1.71	No	No	0	1	2
254	R:R:C268	R:R:V264	1.71	No	No	0	8	7
255	R:R:G182	R:R:N196	1.7	No	No	0	5	3
256	R:R:I80	R:R:P156	1.69	No	No	0	5	3
257	R:R:C132	R:R:T128	1.69	No	No	0	8	7
258	R:R:A104	R:R:T47	1.68	No	No	0	5	5
259	R:R:A289	R:R:T287	1.68	No	No	0	1	1
260	R:R:C59	R:R:I55	1.64	No	No	0	5	4
261	R:R:L96	R:R:P97	1.64	Yes	No	0	7	8
262	R:R:L105	R:R:P109	1.64	No	No	0	5	4
263	R:R:L175	R:R:P176	1.64	No	No	0	4	8
264	R:R:L270	R:R:P271	1.64	No	No	0	5	9
265	R:R:S322	R:R:V67	1.62	No	No	0	5	7
266	R:R:C193	R:R:M119	1.62	No	Yes	0	9	5
267	R:R:S237	R:R:V238	1.62	No	No	0	5	5
268	R:R:S281	R:R:V277	1.62	No	No	0	4	5
269	R:R:V117	R:R:V121	1.6	No	No	0	5	5
270	R:R:V254	R:R:V258	1.6	No	Yes	2	8	8
271	R:R:S259	R:R:T255	1.6	No	No	0	4	7
272	R:R:A307	R:R:L311	1.58	No	No	0	6	8
273	R:R:I284	R:R:S278	1.55	No	No	0	1	4
274	R:R:I284	R:R:S279	1.55	No	No	0	1	4
275	R:R:I49	R:R:V53	1.54	No	No	0	5	7
276	R:R:I114	R:R:V118	1.54	No	No	0	6	5
277	R:R:I209	R:R:V277	1.54	Yes	No	0	5	5
278	R:R:I231	R:R:V235	1.54	No	No	0	9	8
279	R:R:I232	R:R:V254	1.54	No	No	2	5	8
280	R:R:I232	R:R:V258	1.54	No	Yes	2	5	8
281	R:R:I260	R:R:V264	1.54	No	No	0	6	7
282	R:R:H146	R:R:P147	1.53	No	No	0	5	8
283	R:R:K321	R:R:S322	1.53	No	No	0	5	5
284	R:R:I174	R:R:T120	1.52	No	No	0	7	6
285	R:R:K234	R:R:V145	1.52	No	No	0	5	7
286	R:R:I162	R:R:T158	1.52	No	No	0	5	5
287	R:R:I223	R:R:T222	1.52	Yes	No	0	6	4
288	R:R:I232	R:R:T255	1.52	No	No	0	5	7
289	R:R:M257	R:R:V258	1.52	No	Yes	0	8	8
290	R:R:F110	R:R:G111	1.51	Yes	No	0	6	7
291	R:R:F127	R:R:G216	1.51	Yes	No	0	6	6
292	R:R:K75	R:R:T76	1.5	No	No	0	7	7
293	R:R:L142	R:R:S150	1.5	No	No	0	4	5
294	R:R:L240	R:R:V238	1.49	No	No	0	3	5
295	R:R:L327	R:R:V326	1.49	No	Yes	0	7	5
296	R:R:L40	R:R:T41	1.47	No	No	0	2	4
297	R:R:I210	R:R:I214	1.47	No	No	0	5	4
298	R:R:I80	R:R:M74	1.46	No	No	0	5	7
299	R:R:I162	R:R:M161	1.46	No	No	0	5	1
300	L:L:G2	R:R:Y205	1.45	No	Yes	0	0	4
301	R:R:I80	R:R:K160	1.45	No	No	0	5	1
302	R:R:K73	R:R:M74	1.44	No	No	0	5	7
303	R:R:P156	R:R:R155	1.44	No	No	0	3	6
304	R:R:I124	R:R:L171	1.43	No	No	0	5	3
305	R:R:I233	R:R:L229	1.43	No	No	0	3	4
306	R:R:I284	R:R:L290	1.43	No	No	0	1	4
307	R:R:I310	R:R:L315	1.43	No	No	0	6	6
308	R:R:I82	R:R:N79	1.42	No	No	0	8	8
309	R:R:G168	R:R:W167	1.41	No	Yes	0	4	9
310	R:R:A181	R:R:R116	1.38	No	No	0	4	6
311	R:R:D248	R:R:L251	1.36	No	Yes	0	3	6
312	R:R:K320	R:R:Q324	1.36	No	No	0	8	4
313	L:L:F11	L:L:S13	1.32	Yes	No	0	0	0
314	R:R:F131	R:R:V169	1.31	No	No	0	6	4
315	R:R:F296	R:R:V299	1.31	No	No	0	5	5
316	R:R:F110	R:R:M101	1.24	Yes	No	0	6	5
317	R:R:F314	R:R:L63	1.22	Yes	No	0	7	6
318	R:R:F296	R:R:L300	1.22	No	No	0	5	7
319	R:R:N250	R:R:R249	1.21	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F6	5.188	5	4	0
2	L:L:W8	4.65833	6	1	0
3	L:L:K9	6.22	4	6	0
4	L:L:F11	4.555	4	4	0
5	L:L:T12	3.47	4	5	0
6	R:R:Y50	7.355	4	0	7
7	R:R:I65	3.2625	4	10	7
8	R:R:Y71	7.4275	4	7	6
9	R:R:Y81	4.36571	7	3	7
10	R:R:L83	3.5325	4	10	6
11	R:R:D89	5.884	5	0	9
12	R:R:F92	7.29667	6	6	6
13	R:R:M93	2.9875	4	0	6
14	R:R:L96	6.185	4	0	7
15	R:R:W108	8.65833	6	8	8
16	R:R:F110	7.582	5	8	6
17	R:R:M119	2.4475	4	1	5
18	R:R:N125	5.9375	4	0	7
19	R:R:F127	3.29333	6	0	6
20	R:R:T134	3.535	4	2	7
21	R:R:Y141	6.846	5	11	8
22	R:R:R154	7.5725	4	3	5
23	R:R:W167	4.515	4	3	9
24	R:R:I177	3.97	4	1	3
25	R:R:R184	4.64	4	5	2
26	R:R:W197	8.19667	6	1	5
27	R:R:Y205	7.15	5	0	4
28	R:R:F208	6.3125	4	1	7
29	R:R:I209	2.8025	4	0	5
30	R:R:F217	3.336	5	1	8
31	R:R:L221	3.44	4	1	6
32	R:R:I223	3.0225	4	2	6
33	R:R:Y228	3.356	5	2	9
34	R:R:L251	2.915	4	0	6
35	R:R:V258	2.7425	4	2	8
36	R:R:F265	2.69	5	1	9
37	R:R:W269	5.102	5	1	8
38	R:R:F272	6.406	5	0	6
39	R:R:Y273	5.99	5	1	7
40	R:R:K291	6.13	4	0	3
41	R:R:Y302	7.80333	6	6	7
42	R:R:N304	4.225	4	1	9
43	R:R:Y312	3.50714	7	1	9
44	R:R:F314	3.87	4	0	7
45	R:R:V326	5.4575	4	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F7	R:R:Y205	12.8243	10.32	No	Yes	0	0	4
2	L:L:F7	L:L:W8	15.6791	3.01	No	Yes	0	0	0
3	L:L:W8	R:R:M119	100	2.33	Yes	Yes	1	0	5
4	R:R:C193	R:R:M119	97.8332	1.62	No	Yes	0	9	5
5	R:R:C115	R:R:C193	43.8292	7.28	No	No	0	9	9
6	R:R:C115	R:R:W108	41.7836	9.14	No	Yes	0	9	8
7	R:R:Q102	R:R:W108	46.2445	7.67	No	Yes	0	5	8
8	R:R:Q102	R:R:S192	42.0608	7.22	No	No	0	5	4
9	L:L:T12	R:R:S192	37.873	3.2	Yes	No	0	0	4
10	R:R:C193	R:R:L183	52.1761	3.17	No	No	0	9	4
11	R:R:L183	R:R:W108	41.9479	5.69	No	Yes	0	4	8
12	L:L:T12	R:R:R184	16.856	2.59	Yes	Yes	5	0	2
13	L:L:W8	R:R:F272	82.076	5.01	Yes	Yes	0	0	6
14	R:R:F272	R:R:V298	32.2557	2.62	Yes	No	0	6	6
15	R:R:F294	R:R:V298	37.3288	5.24	No	No	0	4	6
16	L:L:F6	R:R:F294	31.1261	11.79	Yes	No	4	0	4
17	L:L:F11	L:L:F6	14.2681	2.14	Yes	Yes	4	0	0
18	L:L:F6	R:R:S279	11.1688	3.96	Yes	No	0	0	4
19	R:R:F208	R:R:W197	10.3083	7.02	Yes	Yes	1	7	5
20	L:L:W8	R:R:T212	37.7457	6.06	Yes	No	1	0	4
21	R:R:F208	R:R:T212	11.0004	5.19	Yes	No	1	7	4
22	L:L:K9	R:R:V298	19.7211	4.55	Yes	No	0	0	6
23	L:L:K9	R:R:F92	18.4415	2.48	Yes	Yes	6	0	6
24	R:R:F272	R:R:T301	50.724	3.89	Yes	No	0	6	7
25	R:R:T301	R:R:Y302	20.3763	6.24	No	Yes	0	7	7
26	R:R:F92	R:R:Y302	18.117	12.38	Yes	Yes	6	6	7
27	R:R:M93	R:R:Y302	12.1259	2.39	Yes	Yes	0	6	7
28	R:R:L96	R:R:Y302	14.2907	8.21	Yes	Yes	0	7	7
29	R:R:L96	R:R:Y50	10.0166	11.72	Yes	Yes	0	7	7
30	R:R:T212	R:R:Y273	49.313	2.5	No	Yes	1	4	7
31	R:R:W269	R:R:Y273	75.7029	5.79	Yes	Yes	1	8	7
32	R:R:N304	R:R:W269	65.6637	4.52	Yes	Yes	1	9	8
33	R:R:N304	R:R:N308	64.1993	6.81	Yes	No	0	9	9
34	R:R:D89	R:R:N308	28.565	6.73	Yes	No	0	9	9
35	R:R:F272	R:R:Y273	58.1692	7.22	Yes	Yes	0	6	7
36	R:R:T301	R:R:W269	49.4732	2.43	No	Yes	0	7	8
37	R:R:F92	R:R:S305	31.7382	2.64	Yes	No	0	6	8
38	R:R:D89	R:R:S305	31.6232	8.83	Yes	No	0	9	8
39	R:R:D89	R:R:N61	34.2624	6.73	Yes	No	0	9	9
40	R:R:N61	R:R:P309	26.7802	4.89	No	No	0	9	9
41	R:R:P309	R:R:V64	25.4801	3.53	No	No	0	9	9
42	R:R:F314	R:R:V64	22.8614	2.62	Yes	No	0	7	9
43	R:R:F314	R:R:F319	17.5851	5.36	Yes	No	0	7	8
44	R:R:F319	R:R:F323	10.9039	8.57	No	No	0	8	6
45	R:R:F217	R:R:Y273	32.4426	3.09	Yes	Yes	1	8	7
46	R:R:F217	R:R:F265	31.2309	2.14	Yes	Yes	1	8	9
47	R:R:F265	R:R:L133	81.1292	2.44	Yes	No	1	9	9
48	R:R:L133	R:R:Y312	78.7036	4.69	No	Yes	1	9	9
49	R:R:M136	R:R:Y312	73.988	4.79	No	Yes	0	9	9
50	R:R:M136	R:R:Y81	72.0348	4.79	No	Yes	0	9	7
51	R:R:I162	R:R:Y81	32.0997	4.84	No	Yes	0	5	7
52	R:R:I162	R:R:T158	27.9796	1.52	No	No	0	5	5
53	R:R:R155	R:R:T158	25.8518	3.88	No	No	0	6	5
54	R:R:P156	R:R:R155	21.5839	1.44	No	No	0	3	6
55	R:R:I80	R:R:P156	19.4438	1.69	No	No	0	5	3
56	R:R:I80	R:R:M74	15.1513	1.46	No	No	0	5	7
57	R:R:K73	R:R:M74	12.9988	1.44	No	No	0	5	7
58	R:R:F265	R:R:W269	51.7345	4.01	Yes	Yes	1	9	8
59	R:R:N308	R:R:Y312	64.3862	5.81	No	Yes	0	9	9
60	R:R:K73	R:R:K75	10.8423	7.18	No	No	0	5	7
61	R:R:I77	R:R:Y81	17.0449	3.63	No	Yes	3	4	7
62	R:R:D139	R:R:Y81	17.164	5.75	No	Yes	3	8	7
63	R:R:I77	R:R:R154	14.913	5.01	No	Yes	3	4	5
64	R:R:D139	R:R:R154	15.0363	13.1	No	Yes	3	8	5
65	R:R:Q126	R:R:W269	14.607	8.76	No	Yes	0	7	8
66	R:R:F127	R:R:Q126	16.6978	7.03	Yes	No	0	6	7
67	R:R:F98	R:R:W108	12.6415	5.01	No	Yes	8	5	8
68	R:R:F110	R:R:W108	12.6291	19.04	Yes	Yes	8	6	8
69	R:R:R140	R:R:Y312	83.2077	2.06	No	Yes	0	9	9
70	R:R:R140	R:R:Y228	81.2565	3.09	No	Yes	0	9	9
71	R:R:I224	R:R:Y228	19.8505	2.42	No	Yes	2	7	9
72	R:R:I224	R:R:T134	17.6775	3.04	No	Yes	2	7	7
73	R:R:I231	R:R:Y228	43.5745	2.42	No	Yes	0	9	9
74	R:R:I231	R:R:Y141	24.2396	2.42	No	Yes	0	9	8
75	R:R:V145	R:R:Y141	13.2576	12.62	No	Yes	11	7	8
76	R:R:R154	R:R:S150	21.5018	5.27	Yes	No	0	5	5
77	R:R:S150	R:R:W153	12.9126	2.47	No	No	0	5	3
78	R:R:I209	R:R:N276	12.3909	2.83	Yes	No	0	5	6
79	R:R:V258	R:R:Y228	15.3546	6.31	Yes	Yes	2	8	9
80	R:R:K234	R:R:V145	11.0785	1.52	No	No	0	5	7
81	R:R:I231	R:R:V235	17.5481	1.54	No	No	0	9	8
82	R:R:L251	R:R:V235	15.3505	2.98	Yes	No	0	6	8
83	R:R:F272	R:R:N276	13.845	13.29	Yes	No	0	6	6
84	R:R:D89	R:R:L85	15.56	2.71	Yes	No	0	9	9
85	R:R:L85	R:R:Y312	14.6994	2.34	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:A1	R:R:E200	3.02	0	No	No	0	4	0	1
L:L:G2	R:R:E200	4.91	0	No	No	0	4	0	1
L:L:C3	R:R:R184	8.36	5	No	Yes	0	2	0	1
L:L:K4	R:R:Y205	14.33	0	No	Yes	0	4	0	1
L:L:K4	R:R:V280	3.04	0	No	No	0	4	0	1
L:L:N5	R:R:P286	6.52	4	No	No	0	2	0	1
L:L:F6	R:R:F275	3.22	4	Yes	No	0	4	0	1
L:L:F6	R:R:S279	3.96	4	Yes	No	0	4	0	1
L:L:F6	R:R:F294	11.79	4	Yes	No	0	4	0	1
L:L:F7	R:R:Y205	10.32	0	No	Yes	0	4	0	1
L:L:F7	R:R:I209	3.77	0	No	Yes	0	5	0	1
L:L:W8	R:R:M119	2.33	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:I177	3.52	1	Yes	Yes	0	3	0	1
L:L:W8	R:R:F208	8.02	1	Yes	Yes	0	7	0	1
L:L:W8	R:R:T212	6.06	1	Yes	No	0	4	0	1
L:L:W8	R:R:F272	5.01	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:F92	2.48	6	Yes	Yes	0	6	0	1
L:L:K9	R:R:D122	8.3	6	Yes	No	0	6	0	1
L:L:K9	R:R:V298	4.55	6	Yes	No	0	6	0	1
L:L:K9	R:R:Y302	9.55	6	Yes	Yes	0	7	0	1
L:L:T10	R:R:T194	3.14	0	No	No	0	4	0	1
L:L:F11	R:R:K291	9.93	4	Yes	Yes	0	3	0	1
L:L:T12	R:R:R184	2.59	5	Yes	Yes	0	2	0	1
L:L:T12	R:R:S192	3.2	5	Yes	No	0	4	0	1
L:L:T12	R:R:T194	4.71	5	Yes	No	0	4	0	1
L:L:S13	R:R:V106	3.23	0	No	No	0	4	0	1
L:L:C14	R:R:R184	2.79	5	No	Yes	0	2	0	1
R:R:K291	R:R:N43	2.8	0	Yes	No	3	3	1	2
R:R:D122	R:R:F92	10.75	6	No	Yes	6	6	1	1
R:R:F92	R:R:N125	9.67	6	Yes	Yes	6	7	1	2
R:R:F92	R:R:Q126	5.86	6	Yes	No	6	7	1	2
R:R:F92	R:R:Y302	12.38	6	Yes	Yes	6	7	1	1
R:R:F92	R:R:S305	2.64	6	Yes	No	6	8	1	2
R:R:M93	R:R:Y302	2.39	0	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	8.21	0	Yes	Yes	7	7	2	1
R:R:Q102	R:R:S192	7.22	0	No	No	5	4	2	1
R:R:I177	R:R:M119	2.92	1	Yes	Yes	3	5	1	1
R:R:I195	R:R:M119	2.92	1	No	Yes	5	5	2	1
R:R:D122	R:R:Y302	8.05	6	No	Yes	6	7	1	1
R:R:I177	R:R:I195	4.42	1	Yes	No	3	5	1	2
R:R:F208	R:R:I177	5.02	1	Yes	Yes	7	3	1	1
R:R:N196	R:R:R184	4.82	0	No	Yes	3	2	2	1
R:R:I195	R:R:W197	12.92	1	No	Yes	5	5	2	2
R:R:W197	R:R:Y205	6.75	1	Yes	Yes	5	4	2	1
R:R:F208	R:R:W197	7.02	1	Yes	Yes	7	5	1	2
R:R:G202	R:R:Y205	2.9	0	No	Yes	2	4	2	1
R:R:T206	R:R:V280	3.17	0	No	No	3	4	2	1
R:R:F208	R:R:T212	5.19	1	Yes	No	7	4	1	1
R:R:I209	R:R:N276	2.83	0	Yes	No	5	6	1	2
R:R:I209	R:R:V280	3.07	0	Yes	No	5	4	1	1
R:R:T212	R:R:Y273	2.5	1	No	Yes	4	7	1	2
R:R:F272	R:R:Y273	7.22	0	Yes	Yes	6	7	1	2
R:R:F272	R:R:N276	13.29	0	Yes	No	6	6	1	2
R:R:F272	R:R:V298	2.62	0	Yes	No	6	6	1	1
R:R:F272	R:R:T301	3.89	0	Yes	No	6	7	1	2
R:R:F275	R:R:M293	3.73	4	No	No	4	4	1	2
R:R:F275	R:R:F294	9.65	4	No	No	4	4	1	1
R:R:G292	R:R:K291	3.49	0	No	Yes	1	3	2	1
R:R:D295	R:R:K291	8.3	9	No	Yes	2	3	2	1
R:R:F294	R:R:V298	5.24	4	No	No	4	6	1	1
R:R:T301	R:R:Y302	6.24	0	No	Yes	7	7	2	1
R:R:P286	R:R:S285	1.78	0	No	No	2	2	1	2
R:R:C193	R:R:M119	1.62	0	No	Yes	9	5	2	1
R:R:I284	R:R:S279	1.55	0	No	No	1	4	2	1
R:R:I209	R:R:V277	1.54	0	Yes	No	5	5	1	2
L:L:G2	R:R:Y205	1.45	0	No	Yes	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T10_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.06
Number of Linked Nodes	280
Number of Links	319
Number of Hubs	45
Number of Links mediated by Hubs	177
Number of Communities	11
Number of Nodes involved in Communities	66
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	120176
Length Of Smallest Path	3
Average Path Length	14.8611
Length of Longest Path	31
Minimum Path Strength	1.265
Average Path Strength	4.63672
Maximum Path Strength	14.425
Minimum Path Correlation	0.7
Average Path Correlation	0.92238
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	42.7883
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.8205
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • GDP binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular process • cell division • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of molecular function • regulation of adenylate cyclase activity
Gene Ontology	Biological Process	• cellular process • cell division • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of autophagy • catabolic process • macroautophagy • autophagy • positive regulation of biological process • regulation of catabolic process • regulation of autophagy • positive regulation of catabolic process • positive regulation of metabolic process • regulation of macroautophagy • metabolic process • positive regulation of macroautophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of cellular process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • purine nucleoside triphosphate metabolic process • GTP metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • nucleoside triphosphate metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytoplasm • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • response to acid chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • regulation of biological quality • somatostatin signaling pathway • hormone-mediated signaling pathway • somatostatin receptor signaling pathway • cell-cell signaling • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • response to osmotic stress • hyperosmotic response • response to stress • response to abiotic stimulus • cell surface receptor signaling pathway • negative regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to steroid hormone • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient levels • response to nutrient • response to pH • response to acidic pH • multicellular organismal process • digestion • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • GABA-ergic synapse • somatodendritic compartment • cell body • neuronal cell body • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • neuropeptide binding • peptide binding • PDZ domain binding • protein domain specific binding • G protein-coupled opioid receptor activity • dynorphin receptor activity • receptor serine/threonine kinase binding • signaling receptor binding • neuropeptide signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to estradiol • cellular response to estradiol stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • response to corticosteroid • cellular response to steroid hormone stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • G protein-coupled opioid receptor signaling pathway • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • response to hexose • cellular response to carbohydrate stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • adenylate cyclase-inhibiting opioid receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • saliva secretion • regulation of saliva secretion • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • perikaryon • presynapse • presynaptic membrane • dendrite • dendritic tree • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • mitochondrion • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Somatostatin-14
UniProt	P61278
Sequence	>7T10_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7T10_nogp_Chain_R L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S G S K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V L V R L L S R E K D R N L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

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