psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	4.03	No	Yes	1	0	0
2	L:L:?1	L:L:C7	6.72	No	No	1	0	0
3	L:L:?1	L:L:T8	6.25	No	No	1	0	0
4	L:L:C2	L:L:C7	7.28	Yes	No	1	0	0
5	L:L:C2	R:R:F294	12.57	Yes	Yes	1	0	4
6	L:L:?4	L:L:F3	5.8	Yes	Yes	1	0	0
7	L:L:F3	R:R:I195	3.77	Yes	Yes	1	0	5
8	L:L:F3	R:R:N196	7.25	Yes	Yes	1	0	3
9	L:L:F3	R:R:Y205	7.22	Yes	Yes	1	0	4
10	L:L:F3	R:R:I209	7.54	Yes	No	0	0	5
11	L:L:?4	L:L:K5	22.39	Yes	No	1	0	0
12	L:L:?4	R:R:Q126	7.4	Yes	Yes	1	0	7
13	L:L:?4	R:R:I195	5.66	Yes	Yes	1	0	5
14	L:L:?4	R:R:T212	3.51	Yes	No	0	0	4
15	L:L:?4	R:R:F272	6.77	Yes	No	0	0	6
16	L:L:?4	R:R:N276	9.81	Yes	No	1	0	6
17	L:L:?4	R:R:F294	5.8	Yes	Yes	1	0	4
18	L:L:K5	R:R:D122	8.3	No	No	1	0	6
19	L:L:K5	R:R:Q126	8.14	No	Yes	1	0	7
20	L:L:T6	R:R:S192	3.2	No	No	0	0	4
21	L:L:C7	R:R:K291	3.23	No	No	0	0	3
22	L:L:T8	R:R:N186	5.85	No	Yes	1	0	1
23	L:L:T8	R:R:Q187	4.25	No	Yes	1	0	2
24	R:R:N43	R:R:T41	8.77	No	No	0	3	4
25	R:R:D295	R:R:L46	13.57	No	No	0	2	5
26	R:R:I49	R:R:V299	9.22	No	No	0	5	5
27	R:R:L96	R:R:Y50	5.86	Yes	Yes	1	7	7
28	R:R:V103	R:R:Y50	7.57	No	Yes	1	4	7
29	R:R:D295	R:R:Y50	16.09	No	Yes	1	2	7
30	R:R:V298	R:R:Y50	6.31	No	Yes	0	6	7
31	R:R:V299	R:R:Y50	8.83	No	Yes	0	5	7
32	R:R:F51	R:R:I55	11.3	No	No	0	5	4
33	R:R:I56	R:R:V53	3.07	Yes	No	0	4	7
34	R:R:V299	R:R:V53	3.21	No	No	0	5	7
35	R:R:C54	R:R:L96	6.35	No	Yes	1	6	7
36	R:R:C54	R:R:P97	5.65	No	No	1	6	8
37	R:R:G57	R:R:I56	3.53	No	Yes	6	8	4
38	R:R:C306	R:R:I56	8.18	No	Yes	6	8	4
39	R:R:G57	R:R:M93	5.24	No	No	0	8	6
40	R:R:C306	R:R:G57	3.92	No	No	6	8	8
41	R:R:E90	R:R:L58	5.3	No	No	0	7	6
42	R:R:C59	R:R:G60	3.92	No	No	0	5	8
43	R:R:D89	R:R:N61	6.73	Yes	No	2	9	9
44	R:R:E90	R:R:N61	11.83	No	No	0	7	9
45	R:R:N61	R:R:P309	4.89	No	No	2	9	9
46	R:R:E90	R:R:T62	5.64	No	No	0	7	5
47	R:R:I68	R:R:V64	3.07	Yes	Yes	0	7	9
48	R:R:A313	R:R:V64	3.39	No	Yes	0	7	9
49	R:R:R70	R:R:Y66	3.09	No	No	0	4	3
50	R:R:F323	R:R:V67	3.93	No	No	0	6	7
51	R:R:A72	R:R:I68	3.25	No	Yes	0	5	7
52	R:R:I68	R:R:L83	5.71	Yes	Yes	0	7	6
53	R:R:F319	R:R:I68	5.02	Yes	Yes	0	8	7
54	R:R:L69	R:R:L83	4.15	No	Yes	0	3	6
55	R:R:R70	R:R:Y71	7.2	No	Yes	0	4	6
56	R:R:N325	R:R:Y71	9.3	No	Yes	7	4	6
57	R:R:V326	R:R:Y71	12.62	No	Yes	7	5	6
58	R:R:A72	R:R:N79	6.25	No	No	0	5	8
59	R:R:I80	R:R:M74	5.83	No	No	0	5	7
60	R:R:L83	R:R:M74	4.24	Yes	No	0	6	7
61	R:R:T76	R:R:T78	4.71	No	No	0	7	8
62	R:R:N79	R:R:T76	4.39	No	No	0	8	7
63	R:R:I77	R:R:Y81	3.63	Yes	Yes	4	4	7
64	R:R:D139	R:R:I77	4.2	No	Yes	4	8	4
65	R:R:I77	R:R:R154	10.02	Yes	Yes	4	4	5
66	R:R:I77	R:R:P156	5.08	Yes	No	0	4	3
67	R:R:A159	R:R:I77	3.25	No	Yes	0	7	4
68	R:R:V135	R:R:Y81	5.05	No	Yes	4	7	7
69	R:R:M136	R:R:Y81	5.99	Yes	Yes	0	9	7
70	R:R:D139	R:R:Y81	10.34	No	Yes	4	8	7
71	R:R:I162	R:R:Y81	3.63	Yes	Yes	4	5	7
72	R:R:I87	R:R:L83	4.28	No	Yes	0	7	6
73	R:R:C132	R:R:N84	6.3	No	No	0	8	9
74	R:R:N84	R:R:T163	8.77	No	No	0	9	7
75	R:R:D89	R:R:L85	5.43	Yes	Yes	2	9	9
76	R:R:C132	R:R:L85	6.35	No	Yes	0	8	9
77	R:R:L133	R:R:L85	4.15	No	Yes	2	9	9
78	R:R:L85	R:R:Y312	3.52	Yes	Yes	2	9	9
79	R:R:D89	R:R:S129	5.89	Yes	No	0	9	9
80	R:R:D89	R:R:S305	8.83	Yes	No	0	9	8
81	R:R:D89	R:R:P309	4.83	Yes	No	2	9	9
82	R:R:L91	R:R:N125	6.87	No	No	0	7	7
83	R:R:D122	R:R:F92	7.17	No	Yes	1	6	6
84	R:R:F92	R:R:N125	7.25	Yes	No	0	6	7
85	R:R:F92	R:R:Q126	5.86	Yes	Yes	1	6	7
86	R:R:F92	R:R:Y302	7.22	Yes	Yes	1	6	7
87	R:R:F92	R:R:S305	7.93	Yes	No	0	6	8
88	R:R:L96	R:R:P97	4.93	Yes	No	1	7	8
89	R:R:L96	R:R:Y302	12.89	Yes	Yes	1	7	7
90	R:R:F98	R:R:V118	6.55	No	No	0	5	5
91	R:R:L99	R:R:Y302	5.86	No	Yes	0	6	7
92	R:R:M101	R:R:P109	3.35	No	Yes	3	5	4
93	R:R:F110	R:R:M101	4.98	Yes	No	3	6	5
94	R:R:Q102	R:R:W108	20.81	No	Yes	3	5	8
95	R:R:P109	R:R:Q102	3.16	Yes	No	3	4	5
96	R:R:Q102	R:R:S192	7.22	No	No	0	5	4
97	R:R:D295	R:R:V103	13.15	No	No	1	2	4
98	R:R:H107	R:R:L105	12.86	No	No	0	4	5
99	R:R:N186	R:R:V106	7.39	Yes	No	1	1	4
100	R:R:V106	R:R:W188	12.26	No	No	1	4	2
101	R:R:R190	R:R:V106	5.23	No	No	0	1	4
102	R:R:H107	R:R:P109	6.1	No	Yes	0	4	4
103	R:R:H107	R:R:R190	3.39	No	No	0	4	1
104	R:R:P109	R:R:W108	5.4	Yes	Yes	3	4	8
105	R:R:F110	R:R:W108	11.02	Yes	Yes	3	6	8
106	R:R:C115	R:R:W108	5.22	No	Yes	3	9	8
107	R:R:L183	R:R:W108	4.56	Yes	Yes	3	4	8
108	R:R:C193	R:R:W108	11.75	Yes	Yes	3	9	8
109	R:R:F110	R:R:P109	17.34	Yes	Yes	3	6	4
110	R:R:G111	R:R:K112	3.49	No	No	0	7	3
111	R:R:K112	R:R:L183	5.64	No	Yes	0	3	4
112	R:R:C115	R:R:L183	4.76	No	Yes	3	9	4
113	R:R:C115	R:R:C193	5.46	No	Yes	3	9	9
114	R:R:A181	R:R:R116	4.15	No	No	0	4	6
115	R:R:T120	R:R:V117	3.17	No	No	0	6	5
116	R:R:M119	R:R:V118	3.04	No	No	0	5	5
117	R:R:C193	R:R:M119	3.24	Yes	No	0	9	5
118	R:R:N125	R:R:V121	4.43	No	No	0	7	5
119	R:R:D122	R:R:Y302	5.75	No	Yes	1	6	7
120	R:R:I124	R:R:W167	3.52	Yes	No	0	5	9
121	R:R:I124	R:R:S170	4.64	Yes	No	0	5	7
122	R:R:I124	R:R:L171	4.28	Yes	No	0	5	3
123	R:R:I124	R:R:I174	4.42	Yes	No	0	5	7
124	R:R:Q126	R:R:W269	10.95	Yes	Yes	1	7	8
125	R:R:F127	R:R:F131	8.57	Yes	No	0	6	6
126	R:R:F127	R:R:V173	6.55	Yes	No	0	6	4
127	R:R:T128	R:R:W167	15.77	No	No	0	7	9
128	R:R:S170	R:R:T128	3.2	No	No	0	7	7
129	R:R:I130	R:R:P220	3.39	No	Yes	0	8	9
130	R:R:F265	R:R:I130	3.77	No	No	1	9	8
131	R:R:I130	R:R:W269	5.87	No	Yes	1	8	8
132	R:R:F131	R:R:V169	3.93	No	No	0	6	4
133	R:R:C132	R:R:M136	3.24	No	Yes	0	8	9
134	R:R:L133	R:R:N308	8.24	No	No	0	9	9
135	R:R:L133	R:R:Y312	4.69	No	Yes	2	9	9
136	R:R:I138	R:R:T134	3.04	No	No	0	6	7
137	R:R:P220	R:R:T134	3.5	Yes	No	0	9	7
138	R:R:I223	R:R:T134	4.56	No	No	0	6	7
139	R:R:I162	R:R:V135	3.07	Yes	No	4	5	7
140	R:R:M136	R:R:Y312	7.18	Yes	Yes	0	9	9
141	R:R:I224	R:R:S137	6.19	No	No	0	7	9
142	R:R:C227	R:R:S137	5.16	No	No	0	7	9
143	R:R:S137	R:R:Y228	3.82	No	Yes	0	9	9
144	R:R:D139	R:R:R154	7.15	No	Yes	4	8	5
145	R:R:R140	R:R:Y228	7.2	No	Yes	2	9	9
146	R:R:R140	R:R:Y312	10.29	No	Yes	2	9	9
147	R:R:L142	R:R:Y141	3.52	No	Yes	0	4	8
148	R:R:V145	R:R:Y141	11.36	No	Yes	0	7	8
149	R:R:C227	R:R:Y141	8.06	No	Yes	0	7	8
150	R:R:F230	R:R:Y141	10.32	No	Yes	0	4	8
151	R:R:A143	R:R:R154	4.15	No	Yes	0	8	5
152	R:R:I231	R:R:V144	12.29	No	No	0	9	8
153	R:R:K234	R:R:V145	10.62	No	No	0	5	7
154	R:R:H146	R:R:K149	27.51	No	No	0	5	4
155	R:R:K149	R:R:W153	15.08	No	No	0	4	3
156	R:R:R154	R:R:S150	7.91	Yes	No	0	5	5
157	R:R:K152	R:R:W153	4.64	No	No	0	4	3
158	R:R:R155	R:R:R157	9.6	No	No	0	6	4
159	R:R:R155	R:R:T158	3.88	No	No	0	6	5
160	R:R:L175	R:R:M178	5.65	No	No	5	4	5
161	R:R:I179	R:R:L175	8.56	No	No	5	4	4
162	R:R:I177	R:R:I195	7.36	No	Yes	1	3	5
163	R:R:F208	R:R:I177	5.02	Yes	No	1	7	3
164	R:R:I179	R:R:M178	5.83	No	No	5	4	5
165	R:R:I179	R:R:Y180	7.25	No	No	5	4	4
166	R:R:P198	R:R:Y180	5.56	No	No	5	5	4
167	R:R:W204	R:R:Y180	3.86	No	No	5	3	4
168	R:R:G182	R:R:W197	4.22	No	No	0	5	5
169	R:R:L183	R:R:S191	7.51	Yes	No	0	4	5
170	R:R:C193	R:R:L183	3.17	Yes	Yes	3	9	4
171	R:R:R184	R:R:T194	9.06	No	No	1	2	4
172	R:R:R184	R:R:W197	14.99	No	No	1	2	5
173	R:R:R184	R:R:Y205	8.23	No	Yes	1	2	4
174	R:R:N186	R:R:Q187	6.6	Yes	Yes	1	1	2
175	R:R:N186	R:R:W188	11.3	Yes	No	1	1	2
176	R:R:Q187	R:R:W188	12.05	Yes	No	1	2	2
177	R:R:P286	R:R:Q187	3.16	No	Yes	0	2	2
178	R:R:G189	R:R:R190	4.5	No	No	0	6	1
179	R:R:T194	R:R:W197	6.06	No	No	1	4	5
180	R:R:I195	R:R:N196	9.91	Yes	Yes	1	5	3
181	R:R:F208	R:R:I195	3.77	Yes	Yes	1	7	5
182	R:R:N196	R:R:Y205	4.65	Yes	Yes	1	3	4
183	R:R:F208	R:R:N196	9.67	Yes	Yes	1	7	3
184	R:R:P198	R:R:W204	9.46	No	No	5	5	3
185	R:R:G202	R:R:Y205	5.79	No	Yes	0	2	4
186	R:R:T206	R:R:V280	4.76	No	No	0	3	4
187	R:R:F208	R:R:I209	3.77	Yes	No	0	7	5
188	R:R:F208	R:R:T212	7.78	Yes	No	0	7	4
189	R:R:I209	R:R:N276	5.66	No	No	0	5	6
190	R:R:F213	R:R:I210	5.02	No	No	0	5	5
191	R:R:L215	R:R:Y211	3.52	No	No	0	4	4
192	R:R:F213	R:R:Y273	7.22	No	Yes	0	5	7
193	R:R:I214	R:R:L218	4.28	No	No	0	4	4
194	R:R:G216	R:R:P220	4.06	No	Yes	0	6	9
195	R:R:F217	R:R:L221	6.09	No	No	0	8	6
196	R:R:F217	R:R:L270	3.65	No	No	0	8	5
197	R:R:F217	R:R:Y273	7.22	No	Yes	0	8	7
198	R:R:P220	R:R:V219	7.07	Yes	No	0	9	5
199	R:R:F265	R:R:L221	6.09	No	No	0	9	6
200	R:R:I266	R:R:L221	5.71	No	No	0	6	6
201	R:R:F230	R:R:L226	13.4	No	No	0	4	5
202	R:R:V258	R:R:Y228	12.62	No	Yes	0	8	9
203	R:R:Y228	R:R:Y312	3.97	Yes	Yes	2	9	9
204	R:R:I232	R:R:V254	3.07	No	No	0	5	8
205	R:R:I232	R:R:T255	4.56	No	No	0	5	7
206	R:R:E251	R:R:V235	9.98	No	No	0	6	8
207	R:R:E251	R:R:K236	4.05	No	No	0	6	4
208	R:R:R247	R:R:S238	3.95	No	No	0	4	5
209	R:R:I240	R:R:V242	3.07	No	No	0	3	3
210	R:R:R247	R:R:V242	5.23	No	No	0	4	3
211	R:R:K246	R:R:S244	3.06	No	No	0	3	3
212	R:R:E251	R:R:R247	18.61	No	No	0	6	4
213	R:R:K252	R:R:R256	8.66	No	No	0	5	6
214	R:R:K253	R:R:R256	7.43	No	No	0	7	6
215	R:R:I260	R:R:R256	6.26	No	No	0	6	6
216	R:R:L315	R:R:M257	5.65	No	No	0	6	8
217	R:R:L311	R:R:V261	8.94	No	No	0	8	8
218	R:R:V261	R:R:Y312	3.79	No	Yes	0	8	9
219	R:R:F265	R:R:W269	7.02	No	Yes	1	9	8
220	R:R:C268	R:R:N304	6.3	No	Yes	0	8	9
221	R:R:W269	R:R:Y273	4.82	Yes	Yes	0	8	7
222	R:R:T301	R:R:W269	13.34	No	Yes	0	7	8
223	R:R:N304	R:R:W269	5.65	Yes	Yes	0	9	8
224	R:R:P271	R:R:V297	3.53	No	No	0	9	7
225	R:R:F272	R:R:Y273	7.22	No	Yes	0	6	7
226	R:R:F272	R:R:V297	3.93	No	No	0	6	7
227	R:R:F275	R:R:S278	3.96	Yes	No	0	4	4
228	R:R:F294	R:R:N276	7.25	Yes	No	1	4	6
229	R:R:I284	R:R:L290	4.28	No	No	0	1	4
230	R:R:P288	R:R:T287	3.5	No	No	0	3	1
231	R:R:L290	R:R:T287	5.9	No	No	0	4	1
232	R:R:F296	R:R:L300	10.96	No	No	0	5	7
233	R:R:V298	R:R:Y302	5.05	No	Yes	0	6	7
234	R:R:N304	R:R:N308	12.26	Yes	No	0	9	9
235	R:R:F314	R:R:I310	3.77	No	No	0	7	6
236	R:R:A313	R:R:F319	6.93	No	Yes	0	7	8
237	R:R:N318	R:R:S316	5.96	No	No	0	5	8
238	R:R:K320	R:R:Q324	6.78	No	No	0	8	4
239	R:R:N325	R:R:V326	10.35	No	No	7	4	5
240	R:R:L215	R:R:V219	2.98	No	No	0	4	5
241	R:R:N304	R:R:V264	2.96	Yes	No	0	9	7
242	R:R:I65	R:R:I87	2.94	No	No	0	7	7
243	R:R:I68	R:R:I82	2.94	Yes	No	0	7	8
244	R:R:I82	R:R:M136	2.92	No	Yes	0	8	9
245	R:R:P156	R:R:R155	2.88	No	No	0	3	6
246	R:R:I260	R:R:L311	2.85	No	No	0	6	8
247	R:R:I274	R:R:L270	2.85	No	No	0	5	5
248	R:R:K149	R:R:L142	2.82	No	No	0	4	4
249	R:R:K291	R:R:N43	2.8	No	No	0	3	3
250	R:R:L58	R:R:L94	2.77	No	No	0	6	5
251	R:R:A100	R:R:Y50	2.67	No	Yes	0	6	7
252	R:R:F127	R:R:S170	2.64	Yes	No	0	6	7
253	R:R:F319	R:R:S316	2.64	Yes	No	0	8	8
254	R:R:F319	R:R:S322	2.64	Yes	No	0	8	5
255	L:L:F3	R:R:V280	2.62	Yes	No	0	0	4
256	R:R:F314	R:R:V64	2.62	No	Yes	0	7	9
257	R:R:F319	R:R:V67	2.62	Yes	No	0	8	7
258	R:R:F131	R:R:V166	2.62	No	No	0	6	6
259	R:R:F127	R:R:T212	2.59	Yes	No	0	6	4
260	R:R:V262	R:R:Y228	2.52	No	Yes	0	7	9
261	R:R:F296	R:R:I49	2.51	No	No	0	5	5
262	R:R:F110	R:R:I114	2.51	Yes	No	0	6	6
263	R:R:F275	R:R:M293	2.49	Yes	No	0	4	4
264	R:R:F267	R:R:L300	2.44	No	No	0	6	7
265	R:R:F275	R:R:L290	2.44	Yes	No	0	4	4
266	R:R:I231	R:R:Y228	2.42	No	Yes	0	9	9
267	R:R:F275	R:R:F294	2.14	Yes	Yes	0	4	4
268	R:R:G95	R:R:P97	2.03	No	No	0	6	8
269	R:R:A181	R:R:G182	1.95	No	No	0	4	5
270	R:R:G207	R:R:T206	1.82	No	No	0	4	3
271	R:R:P286	R:R:S285	1.78	No	No	0	2	2
272	R:R:G123	R:R:I174	1.76	No	No	0	4	7
273	R:R:G292	R:R:K291	1.74	No	No	0	1	3
274	L:L:C2	R:R:S279	1.72	Yes	No	0	0	4
275	R:R:G60	R:R:L63	1.71	No	No	0	8	6
276	R:R:A88	R:R:S129	1.71	No	No	0	8	9
277	R:R:G168	R:R:L171	1.71	No	No	0	4	3
278	R:R:A303	R:R:V53	1.7	No	No	0	5	7
279	R:R:A86	R:R:V64	1.7	No	Yes	0	9	9
280	R:R:A44	R:R:T41	1.68	No	No	0	4	4
281	R:R:A104	R:R:T47	1.68	No	No	0	5	5
282	R:R:A289	R:R:T287	1.68	No	No	0	1	1
283	R:R:C59	R:R:I56	1.64	No	Yes	0	5	4
284	R:R:L175	R:R:P176	1.64	No	No	0	4	8
285	R:R:A165	R:R:I162	1.62	No	Yes	0	4	5
286	R:R:S244	R:R:V242	1.62	No	No	0	3	3
287	R:R:S250	R:R:V254	1.62	No	No	0	5	8
288	R:R:S281	R:R:V277	1.62	No	No	0	4	5
289	R:R:A283	R:R:M282	1.61	No	No	0	4	3
290	R:R:S42	R:R:T41	1.6	No	No	0	4	4
291	R:R:V144	R:R:V235	1.6	No	No	0	8	8
292	R:R:V254	R:R:V258	1.6	No	No	0	8	8
293	R:R:T47	R:R:V103	1.59	No	No	0	5	4
294	R:R:H146	R:R:P147	1.53	No	No	0	5	8
295	R:R:I174	R:R:T120	1.52	No	No	0	7	6
296	R:R:M178	R:R:T120	1.51	No	No	0	5	6
297	R:R:M164	R:R:T163	1.51	No	No	0	4	7
298	R:R:G243	R:R:R241	1.5	No	No	0	1	1
299	R:R:L46	R:R:V45	1.49	No	No	0	5	5
300	R:R:L218	R:R:T222	1.47	No	No	0	4	4
301	R:R:I162	R:R:M161	1.46	Yes	No	0	5	1
302	R:R:K160	R:R:M164	1.44	No	No	0	1	4
303	R:R:K248	R:R:K252	1.44	No	No	0	3	5
304	R:R:K253	R:R:M257	1.44	No	No	0	7	8
305	R:R:K320	R:R:K321	1.44	No	No	0	8	5
306	R:R:A113	R:R:R116	1.38	No	No	0	1	6
307	R:R:H146	R:R:I148	1.33	No	No	0	5	5
308	R:R:F213	R:R:V277	1.31	No	No	0	5	5
309	R:R:V67	R:R:Y71	1.26	No	Yes	0	7	6
310	R:R:F230	R:R:I233	1.26	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:C2	6.4	4	1	0
2	L:L:F3	5.7	6	1	0
3	L:L:?4	8.3925	8	1	0
4	R:R:Y50	7.88833	6	1	7
5	R:R:I56	4.105	4	6	4
6	R:R:V64	2.695	4	0	9
7	R:R:I68	3.998	5	0	7
8	R:R:Y71	7.595	4	7	6
9	R:R:I77	5.236	5	4	4
10	R:R:Y81	5.728	5	4	7
11	R:R:L83	4.595	4	0	6
12	R:R:L85	4.8625	4	2	9
13	R:R:D89	6.342	5	2	9
14	R:R:F92	7.086	5	1	6
15	R:R:L96	7.5075	4	1	7
16	R:R:W108	9.79333	6	3	8
17	R:R:P109	7.07	5	3	4
18	R:R:F110	8.9625	4	3	6
19	R:R:I124	4.215	4	0	5
20	R:R:Q126	8.0875	4	1	7
21	R:R:F127	5.0875	4	0	6
22	R:R:M136	4.8325	4	0	9
23	R:R:Y141	8.315	4	0	8
24	R:R:R154	7.3075	4	4	5
25	R:R:I162	2.445	4	4	5
26	R:R:L183	5.128	5	3	4
27	R:R:N186	7.785	4	1	1
28	R:R:Q187	6.515	4	1	2
29	R:R:C193	5.905	4	3	9
30	R:R:I195	6.094	5	1	5
31	R:R:N196	7.87	4	1	3
32	R:R:Y205	6.4725	4	1	4
33	R:R:F208	6.002	5	1	7
34	R:R:P220	4.505	4	0	9
35	R:R:Y228	5.425	6	2	9
36	R:R:W269	7.94167	6	1	8
37	R:R:Y273	6.62	4	0	7
38	R:R:F275	2.7575	4	0	4
39	R:R:F294	6.94	4	1	4
40	R:R:Y302	7.354	5	1	7
41	R:R:N304	6.7925	4	0	9
42	R:R:Y312	5.57333	6	2	9
43	R:R:F319	3.97	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	43.532	4.03	No	Yes	1	0	0
2	L:L:C2	R:R:F294	56.2413	12.57	Yes	Yes	1	0	4
3	L:L:?4	R:R:F294	67.2927	5.8	Yes	Yes	1	0	4
4	L:L:?4	L:L:F3	22.0121	5.8	Yes	Yes	1	0	0
5	L:L:F3	R:R:Y205	13.7551	7.22	Yes	Yes	1	0	4
6	L:L:?4	L:L:K5	16.773	22.39	Yes	No	1	0	0
7	L:L:?4	R:R:Q126	100	7.4	Yes	Yes	1	0	7
8	L:L:?4	R:R:T212	36.6286	3.51	Yes	No	0	0	4
9	L:L:K5	R:R:D122	17.1486	8.3	No	No	1	0	6
10	L:L:?1	L:L:T8	42.8294	6.25	No	No	1	0	0
11	L:L:T8	R:R:N186	35.5082	5.85	No	Yes	1	0	1
12	R:R:N186	R:R:V106	32.8271	7.39	Yes	No	1	1	4
13	R:R:R190	R:R:V106	31.6711	5.23	No	No	0	1	4
14	R:R:H107	R:R:R190	28.7699	3.39	No	No	0	4	1
15	R:R:H107	R:R:P109	25.8427	6.1	No	Yes	0	4	4
16	R:R:D122	R:R:Y302	16.4395	5.75	No	Yes	1	6	7
17	R:R:L96	R:R:Y302	32.662	12.89	Yes	Yes	1	7	7
18	R:R:L96	R:R:Y50	27.9086	5.86	Yes	Yes	1	7	7
19	R:R:F92	R:R:Q126	72.0688	5.86	Yes	Yes	1	6	7
20	R:R:F92	R:R:Y302	47.1845	7.22	Yes	Yes	1	6	7
21	R:R:V298	R:R:Y302	28.8962	5.05	No	Yes	0	6	7
22	R:R:V298	R:R:Y50	27.7078	6.31	No	Yes	0	6	7
23	R:R:V299	R:R:Y50	35.8547	8.83	No	Yes	0	5	7
24	R:R:I49	R:R:V299	10.3714	9.22	No	No	0	5	5
25	R:R:V299	R:R:V53	23.194	3.21	No	No	0	5	7
26	R:R:I56	R:R:V53	18.0844	3.07	Yes	No	0	4	7
27	R:R:F92	R:R:S305	78.7553	7.93	Yes	No	0	6	8
28	R:R:D89	R:R:S305	78.6776	8.83	Yes	No	0	9	8
29	R:R:D89	R:R:L85	77.8616	5.43	Yes	Yes	2	9	9
30	R:R:C132	R:R:L85	29.4078	6.35	No	Yes	0	8	9
31	R:R:C132	R:R:M136	26.9792	3.24	No	Yes	0	8	9
32	R:R:I82	R:R:M136	48.9914	2.92	No	Yes	0	8	9
33	R:R:I68	R:R:I82	47.3723	2.94	Yes	No	0	7	8
34	R:R:L85	R:R:Y312	49.9919	3.52	Yes	Yes	2	9	9
35	R:R:M136	R:R:Y312	52.7313	7.18	Yes	Yes	0	9	9
36	R:R:Q126	R:R:W269	40.5142	10.95	Yes	Yes	1	7	8
37	R:R:N304	R:R:W269	39.7112	5.65	Yes	Yes	0	9	8
38	R:R:N304	R:R:N308	39.0312	12.26	Yes	No	0	9	9
39	R:R:L133	R:R:N308	38.798	8.24	No	No	0	9	9
40	R:R:L133	R:R:Y312	37.9853	4.69	No	Yes	2	9	9
41	R:R:F319	R:R:I68	20.7687	5.02	Yes	Yes	0	8	7
42	R:R:F319	R:R:V67	12.3466	2.62	Yes	No	0	8	7
43	R:R:I68	R:R:L83	10.6628	5.71	Yes	Yes	0	7	6
44	R:R:M136	R:R:Y81	31.1563	5.99	Yes	Yes	0	9	7
45	R:R:I77	R:R:Y81	15.6526	3.63	Yes	Yes	4	4	7
46	R:R:P109	R:R:W108	15.2317	5.4	Yes	Yes	3	4	8
47	R:R:R184	R:R:Y205	11.3914	8.23	No	Yes	1	2	4
48	R:R:F127	R:R:T212	34.948	2.59	Yes	No	0	6	4
49	R:R:F127	R:R:S170	27.6754	2.64	Yes	No	0	6	7
50	R:R:I124	R:R:S170	23.1551	4.64	Yes	No	0	5	7
51	R:R:I124	R:R:I174	17.1583	4.42	Yes	No	0	5	7
52	R:R:I174	R:R:T120	14.0951	1.52	No	No	0	7	6
53	R:R:Y228	R:R:Y312	39.2773	3.97	Yes	Yes	2	9	9
54	R:R:S137	R:R:Y228	19.6322	3.82	No	Yes	0	9	9
55	R:R:C227	R:R:S137	17.2684	5.16	No	No	0	7	9
56	R:R:C227	R:R:Y141	16.0768	8.06	No	Yes	0	7	8
57	R:R:I231	R:R:Y228	13.5706	2.42	No	Yes	0	9	9
58	R:R:I231	R:R:V144	12.3596	12.29	No	No	0	9	8
59	R:R:M178	R:R:T120	11.0061	1.51	No	No	0	5	6
60	R:R:V144	R:R:V235	11.1388	1.6	No	No	0	8	8
61	R:R:V261	R:R:Y312	11.168	3.79	No	Yes	0	8	9
62	R:R:L311	R:R:V261	10.0152	8.94	No	No	0	8	8
63	R:R:F275	R:R:F294	12.379	2.14	Yes	Yes	0	4	4
64	L:L:C2	L:L:C7	10.1739	7.28	Yes	No	1	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C2	R:R:F294	12.57	1	Yes	Yes	0	4	0	1
L:L:F3	R:R:I195	3.77	1	Yes	Yes	0	5	0	1
L:L:F3	R:R:N196	7.25	1	Yes	Yes	0	3	0	1
L:L:F3	R:R:Y205	7.22	1	Yes	Yes	0	4	0	1
L:L:F3	R:R:I209	7.54	1	Yes	No	0	5	0	1
L:L:?4	R:R:Q126	7.4	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:I195	5.66	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:T212	3.51	1	Yes	No	0	4	0	1
L:L:?4	R:R:F272	6.77	1	Yes	No	0	6	0	1
L:L:?4	R:R:N276	9.81	1	Yes	No	0	6	0	1
L:L:?4	R:R:F294	5.8	1	Yes	Yes	0	4	0	1
L:L:K5	R:R:D122	8.3	1	No	No	0	6	0	1
L:L:K5	R:R:Q126	8.14	1	No	Yes	0	7	0	1
L:L:T6	R:R:S192	3.2	0	No	No	0	4	0	1
L:L:C7	R:R:K291	3.23	1	No	No	0	3	0	1
L:L:T8	R:R:N186	5.85	1	No	Yes	0	1	0	1
L:L:T8	R:R:Q187	4.25	1	No	Yes	0	2	0	1
R:R:D122	R:R:F92	7.17	1	No	Yes	6	6	1	2
R:R:F92	R:R:Q126	5.86	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	7.22	1	Yes	Yes	6	7	2	2
R:R:Q102	R:R:S192	7.22	3	No	No	5	4	2	1
R:R:N186	R:R:V106	7.39	1	Yes	No	1	4	1	2
R:R:V106	R:R:W188	12.26	1	No	No	4	2	2	2
R:R:D122	R:R:Y302	5.75	1	No	Yes	6	7	1	2
R:R:Q126	R:R:W269	10.95	1	Yes	Yes	7	8	1	2
R:R:I177	R:R:I195	7.36	1	No	Yes	3	5	2	1
R:R:F208	R:R:I177	5.02	1	Yes	No	7	3	2	2
R:R:R184	R:R:Y205	8.23	1	No	Yes	2	4	2	1
R:R:N186	R:R:Q187	6.6	1	Yes	Yes	1	2	1	1
R:R:N186	R:R:W188	11.3	1	Yes	No	1	2	1	2
R:R:Q187	R:R:W188	12.05	1	Yes	No	2	2	1	2
R:R:P286	R:R:Q187	3.16	0	No	Yes	2	2	2	1
R:R:I195	R:R:N196	9.91	1	Yes	Yes	5	3	1	1
R:R:F208	R:R:I195	3.77	1	Yes	Yes	7	5	2	1
R:R:N196	R:R:Y205	4.65	1	Yes	Yes	3	4	1	1
R:R:F208	R:R:N196	9.67	1	Yes	Yes	7	3	2	1
R:R:G202	R:R:Y205	5.79	0	No	Yes	2	4	2	1
R:R:T206	R:R:V280	4.76	0	No	No	3	4	2	1
R:R:F208	R:R:I209	3.77	1	Yes	No	7	5	2	1
R:R:F208	R:R:T212	7.78	1	Yes	No	7	4	2	1
R:R:I209	R:R:N276	5.66	0	No	No	5	6	1	1
R:R:W269	R:R:Y273	4.82	1	Yes	Yes	8	7	2	2
R:R:F272	R:R:Y273	7.22	0	No	Yes	6	7	1	2
R:R:F272	R:R:V297	3.93	0	No	No	6	7	1	2
R:R:F294	R:R:N276	7.25	1	Yes	No	4	6	1	1
R:R:K291	R:R:N43	2.8	0	No	No	3	3	1	2
L:L:F3	R:R:V280	2.62	1	Yes	No	0	4	0	1
R:R:F127	R:R:T212	2.59	0	Yes	No	6	4	2	1
R:R:F275	R:R:F294	2.14	0	Yes	Yes	4	4	2	1
R:R:G292	R:R:K291	1.74	0	No	No	1	3	2	1
L:L:C2	R:R:S279	1.72	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y24_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	273
Number of Links	310
Number of Hubs	43
Number of Links mediated by Hubs	161
Number of Communities	7
Number of Nodes involved in Communities	68
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	63702
Length Of Smallest Path	3
Average Path Length	13.9222
Length of Longest Path	30
Minimum Path Strength	1.43
Average Path Strength	6.20107
Maximum Path Strength	21.295
Minimum Path Correlation	0.7
Average Path Correlation	0.929131
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.8228
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.8908
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7Y24_nogp_Chain_R T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

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