Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N43 R:R:V103 4.43 1 Yes Yes 3 4 1 1
R:R:E106 R:R:N43 10.52 1 No Yes 4 3 1 1
L:L:?9 R:R:N43 6.6 1 Yes Yes 0 3 0 1
L:L:?10 R:R:N43 10.27 1 No Yes 0 3 0 1
R:R:L46 R:R:Y50 8.21 1 No Yes 5 7 2 2
R:R:L46 R:R:V103 4.47 1 No Yes 5 4 2 1
R:R:D295 R:R:L46 6.79 1 Yes No 2 5 1 2
R:R:V103 R:R:Y50 5.05 1 Yes Yes 4 7 1 2
R:R:Y302 R:R:Y50 4.96 1 Yes Yes 7 7 2 2
R:R:D122 R:R:F92 5.97 1 No Yes 6 6 1 2
R:R:F92 R:R:Y302 12.38 1 Yes Yes 6 7 2 2
L:L:?9 R:R:V103 4.77 1 Yes Yes 0 4 0 1
L:L:?9 R:R:E106 10.61 1 Yes No 0 4 0 1
R:R:C193 R:R:M119 4.86 6 No No 9 5 2 1
L:L:?5 R:R:M119 5.66 0 Yes No 0 5 0 1
R:R:D122 R:R:Y302 4.6 1 No Yes 6 7 1 2
L:L:K6 R:R:D122 11.06 0 No No 0 6 0 1
R:R:F127 R:R:Q126 10.54 0 Yes Yes 6 7 2 1
R:R:Q126 R:R:W269 7.67 1 Yes Yes 7 8 1 2
R:R:Q126 R:R:Y273 7.89 1 Yes Yes 7 7 1 2
L:L:K6 R:R:Q126 8.14 0 No Yes 0 7 0 1
R:R:I177 R:R:I195 7.36 0 No No 3 5 2 1
L:L:?5 R:R:T194 8.26 0 Yes No 0 4 0 1
R:R:I195 R:R:W197 15.27 0 No Yes 5 5 1 2
L:L:?5 R:R:I195 8 0 Yes No 0 5 0 1
R:R:I209 R:R:Y205 6.04 0 No Yes 5 4 2 1
R:R:S279 R:R:Y205 5.09 0 No Yes 4 4 2 1
L:L:?1 R:R:Y205 12.32 1 No Yes 0 4 0 1
L:L:?2 R:R:Y205 10.98 1 Yes Yes 0 4 0 1
R:R:W269 R:R:Y273 8.68 1 Yes Yes 8 7 2 2
R:R:F275 R:R:M293 9.95 1 No No 4 4 1 2
R:R:F275 R:R:F294 13.93 1 No No 4 4 1 1
L:L:?2 R:R:F275 9.5 1 Yes No 0 4 0 1
L:L:?2 R:R:M282 4.41 1 Yes No 0 3 0 1
R:R:K291 R:R:P286 6.69 1 Yes No 3 2 1 1
L:L:?2 R:R:P286 12.81 1 Yes No 0 2 0 1
R:R:L290 R:R:T287 5.9 0 No Yes 4 1 1 2
L:L:?2 R:R:L290 5.4 1 Yes No 0 4 0 1
L:L:?3 R:R:K291 3.94 1 Yes Yes 0 3 0 1
L:L:C8 R:R:K291 8.08 1 Yes Yes 0 3 0 1
R:R:F294 R:R:V298 7.87 1 No No 4 6 1 2
L:L:?2 R:R:F294 11.41 1 Yes No 0 4 0 1
L:L:T7 R:R:D295 4.34 1 No Yes 0 2 0 1
L:L:C8 R:R:D295 4.67 1 Yes Yes 0 2 0 1
L:L:?9 R:R:D295 6.52 1 Yes Yes 0 2 0 1
R:R:V298 R:R:Y302 5.05 0 No Yes 6 7 2 2
L:L:?10 R:R:S42 3.74 1 No No 0 4 0 1
R:R:P286 R:R:S285 3.56 0 No No 2 2 1 2
R:R:A181 R:R:M119 3.22 0 No No 4 5 2 1
R:R:T47 R:R:V103 3.17 0 No Yes 5 4 2 1
R:R:N43 R:R:T41 2.92 1 Yes No 3 4 1 2
R:R:N196 R:R:T194 2.92 0 No No 3 4 2 1
L:L:Y4 R:R:S192 2.54 0 No No 0 4 0 1
L:L:?1 R:R:S201 2.25 1 No No 0 2 0 1
R:R:G202 R:R:S201 1.86 0 No No 2 2 2 1
R:R:G292 R:R:K291 1.74 0 No Yes 1 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7XNA
Class A
SubFamily Peptide
Type Somatostatin
SubType SST2
Species Homo sapiens
Ligand CYN154806
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.65
Date 2022-08-03
D.O.I. 10.1038/s41422-022-00679-x
Net Summary
Imin 3.92
Number of Linked Nodes 277
Number of Links 308
Number of Hubs 40
Number of Links mediated by Hubs 156
Number of Communities 8
Number of Nodes involved in Communities 54
Number of Links involved in Communities 71
Path Summary
Number Of Nodes in MetaPath 77
Number Of Links MetaPath 76
Number of Shortest Paths 48470
Length Of Smallest Path 3
Average Path Length 12.8616
Length of Longest Path 31
Minimum Path Strength 1.57
Average Path Strength 7.64963
Maximum Path Strength 20.975
Minimum Path Correlation 0.7
Average Path Correlation 0.929329
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 53.5455
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.3285
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeACE
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeACE
NameACETYL GROUP
Synonyms
Identifierethanal
FormulaC2 H4 O
Molecular Weight44.053
SMILESCC=O
PubChem177
Formal Charge0
Total Atoms7
Total Chiral Atoms0
Total Bonds6
Total Aromatic Bonds0

CodePPN
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodePPN
NamePARA-NITROPHENYLALANINE
Synonyms
Identifier(2S)-2-amino-3-(4-nitrophenyl)propanoic acid
FormulaC9 H10 N2 O4
Molecular Weight210.187
SMILESc1cc(ccc1C[C@@H](C(=O)O)N)[N+](=O)[O-]
PubChem6920554
Formal Charge0
Total Atoms25
Total Chiral Atoms1
Total Bonds25
Total Aromatic Bonds6

CodeDCY
PDB ResiduesL:L:?3
Environment DetailsOpen EMBL-EBI Page
CodeDCY
NameD-Cysteine
Synonyms(2S)-2-amino-3-sulfanylpropanoic acid
Identifier(2S)-2-amino-3-sulfanyl-propanoic acid
FormulaC3 H7 N O2 S
Molecular Weight121.158
SMILESC([C@H](C(=O)O)N)S
PubChem92851
Formal Charge0
Total Atoms14
Total Chiral Atoms1
Total Bonds13
Total Aromatic Bonds0

CodeDTR
PDB ResiduesL:L:?5
Environment DetailsOpen EMBL-EBI Page
CodeDTR
NameD-Tryptophan
Synonyms
  • D-Tryptophan
  • (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
  • DTR
  • (R)-tryptophan
Identifier(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
FormulaC11 H12 N2 O2
Molecular Weight204.225
SMILESc1ccc2c(c1)c(c[nH]2)C[C@H](C(=O)O)N
PubChem6923517
Formal Charge0
Total Atoms27
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds10

CodeDTY
PDB ResiduesL:L:?9
Environment DetailsOpen EMBL-EBI Page
CodeDTY
NameD-Tyrosine
Synonyms
  • (R)-3-(p-Hydroxyphenyl)alanine
  • D-Tyrosin
  • D-Tyr
  • (R)-2-Amino-3-(p-hydroxyphenyl)propionic acid
  • D-Tyrosine
Identifier(2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid
FormulaC9 H11 N O3
Molecular Weight181.189
SMILESc1cc(ccc1C[C@H](C(=O)O)N)O
PubChem6919035
Formal Charge0
Total Atoms24
Total Chiral Atoms1
Total Bonds24
Total Aromatic Bonds6

CodeNH2
PDB ResiduesL:L:?10
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier$l^{2}-azane
FormulaH2 N
Molecular Weight16.023
SMILES[NH2]
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP30874
Sequence
>7XNA_Chain_R
TSNAVLTFI YFVVCIIGL CGNTLVIYV ILRYAKMKT ITNIYILNL 
AIANELFML GLPFLAMQV ALEHWPFGK AICRVVMTV DGINQFTSI 
FCLTVMSID RYLAVVHPI KSAKWRRPR TAKMITMAV WGVSLLVIL 
PIMIYAGLR SNQWGRSSC TINWPGESG AWYTGFIIY TFILGFLVP 
LTIICLCYL FIIIKVKSS SKRKKSEKK VTRMVSIVV AVFIFCWLP 
FYIFNVSSV SMAISPTPA LKGMFDFVV VLTYANSCA NPILYAFLD 
DNFKKSFQN VLCLVKVS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
sst2_off7XNA-SST2-CYN154806

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7UL5APeptideSomatostatinSST2Homo sapiens---3.12022-06-2910.1038/s41594-022-00859-8
7WICAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/&β;1/&γ;22.82022-06-0110.1038/s41422-022-00669-z
7WIGAPeptideSomatostatinSST2Homo sapiensL-054,264-Gi1/&β;1/&γ;22.72022-06-0110.1038/s41422-022-00669-z
7WJ5APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/&β;1/&γ;23.722022-07-1310.7554/eLife.76823
7XATAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/&β;1/&γ;22.852022-08-3110.1038/s41421-022-00405-2
7XAUAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/&β;1/&γ;22.972022-08-3110.1038/s41421-022-00405-2
7XAVAPeptideSomatostatinSST2Homo sapiensLanreotide-Gi1/&β;1/&γ;22.872022-08-3110.1038/s41421-022-00405-2
7XMRAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/&β;1/&γ;23.12022-08-0310.1038/s41422-022-00679-x
7XN9APeptideSomatostatinSST2Homo sapiensL-054,522--2.62022-08-0310.1038/s41422-022-00679-x
7XNAAPeptideSomatostatinSST2Homo sapiensCYN154806--2.652022-08-0310.1038/s41422-022-00679-x
7Y24APeptideSomatostatinSST2Homo sapiensOctreotide-Go/&β;1/&γ;23.252022-10-1910.1038/s41589-022-01130-3
7Y26APeptideSomatostatinSST2Homo sapiensOctreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.32022-10-1910.1038/s41589-022-01130-3
7Y27APeptideSomatostatinSST2Homo sapiensSomatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.482022-10-1910.1038/s41589-022-01130-3
7YACAPeptideSomatostatinSST2Homo sapiensPaltusotine-Gi1/&β;1/&γ;23.242023-04-1910.1038/s41467-023-36673-z
7YAEAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/&β;1/&γ;23.372023-04-1910.1038/s41467-023-36673-z




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