Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F9Z | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | GHRP-6 | - | chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 | 3.2 | 2021-08-18 | 10.1038/s41467-021-25364-2 |
![](/psngpcr/ligands/DTR/DTR_7F9Z_L_L_2.png)
A 2D representation of the interactions of DTR in 7F9Z colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?1 | L:L:?2 | 16.25 | 0 | No | Yes | 0 | 0 | 1 | 0 | L:L:?1 | R:R:Y106 | 10.11 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:?1 | R:R:R199 | 5.24 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:?2 | L:L:?3 | 30.44 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:?6 | 9.62 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | R:R:D99 | 5.43 | 3 | Yes | No | 0 | 6 | 0 | 1 | L:L:?2 | R:R:L103 | 8.87 | 3 | Yes | No | 0 | 4 | 0 | 1 | L:L:?2 | R:R:Q302 | 11.72 | 3 | Yes | No | 0 | 3 | 0 | 1 | L:L:?2 | R:R:F309 | 9.75 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?3 | L:L:?4 | 18.04 | 3 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?3 | R:R:F286 | 9.91 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?3 | R:R:N305 | 22.35 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:?4 | L:L:?5 | 14.15 | 3 | Yes | Yes | 0 | 0 | 2 | 2 | L:L:?4 | L:L:?6 | 9.62 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?4 | R:R:F286 | 3.9 | 3 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:?4 | R:R:F309 | 8.78 | 3 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:?5 | L:L:?6 | 28.63 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?5 | L:L:?7 | 5.87 | 3 | Yes | Yes | 0 | 0 | 2 | 2 | L:L:?5 | R:R:E124 | 5.64 | 3 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:?6 | L:L:?7 | 23.95 | 3 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?6 | R:R:D99 | 4.71 | 3 | Yes | No | 0 | 6 | 1 | 1 | L:L:?6 | R:R:Q120 | 21.95 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?6 | R:R:E124 | 6.9 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?6 | R:R:I178 | 4.95 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:?7 | R:R:Q120 | 9.95 | 3 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:?7 | R:R:E124 | 13.21 | 3 | Yes | Yes | 0 | 4 | 2 | 2 | R:R:D99 | R:R:F309 | 9.55 | 3 | No | Yes | 6 | 5 | 1 | 1 | R:R:E124 | R:R:I178 | 6.83 | 3 | Yes | No | 4 | 4 | 2 | 2 | R:R:F309 | R:R:Y313 | 14.44 | 3 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:L306 | R:R:Q302 | 2.66 | 0 | No | No | 4 | 3 | 2 | 1 | R:R:Q302 | R:R:Y303 | 1.13 | 0 | No | No | 3 | 1 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 13.15 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/DTR/DTR_7F9Z_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7F9Z_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/DTR/DTR_7F9Z_L_L_4.png)
A 2D representation of the interactions of DTR in 7F9Z colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:?3 | 30.44 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?2 | L:L:?6 | 9.62 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?2 | R:R:D99 | 5.43 | 3 | Yes | No | 0 | 6 | 2 | 2 | L:L:?2 | R:R:F309 | 9.75 | 3 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:?3 | L:L:?4 | 18.04 | 3 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?3 | R:R:F286 | 9.91 | 3 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?3 | R:R:N305 | 22.35 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:?4 | L:L:?5 | 14.15 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:?6 | 9.62 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | R:R:F286 | 3.9 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?4 | R:R:S308 | 4.81 | 3 | Yes | No | 0 | 7 | 0 | 1 | L:L:?4 | R:R:F309 | 8.78 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?5 | L:L:?6 | 28.63 | 3 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?5 | L:L:?7 | 5.87 | 3 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?5 | R:R:E124 | 5.64 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?5 | R:R:L181 | 11.78 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:?5 | R:R:P200 | 6.99 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:?5 | R:R:M213 | 12.03 | 3 | Yes | No | 0 | 5 | 1 | 2 | L:L:?5 | R:R:R283 | 27.92 | 3 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?6 | L:L:?7 | 23.95 | 3 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?6 | R:R:D99 | 4.71 | 3 | Yes | No | 0 | 6 | 1 | 2 | L:L:?6 | R:R:Q120 | 21.95 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?6 | R:R:E124 | 6.9 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?6 | R:R:I178 | 4.95 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:?7 | R:R:Q120 | 9.95 | 3 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:?7 | R:R:E124 | 13.21 | 3 | Yes | Yes | 0 | 4 | 2 | 2 | R:R:D99 | R:R:F309 | 9.55 | 3 | No | Yes | 6 | 5 | 2 | 1 | R:R:E124 | R:R:I178 | 6.83 | 3 | Yes | No | 4 | 4 | 2 | 2 | R:R:E124 | R:R:R283 | 5.82 | 3 | Yes | Yes | 4 | 6 | 2 | 2 | R:R:L181 | R:R:M213 | 7.07 | 3 | No | No | 4 | 5 | 2 | 2 | R:R:P278 | R:R:S308 | 3.56 | 0 | No | No | 9 | 7 | 2 | 1 | R:R:F286 | R:R:S289 | 3.96 | 3 | Yes | No | 4 | 2 | 1 | 2 | R:R:F286 | R:R:F290 | 8.57 | 3 | Yes | No | 4 | 1 | 1 | 2 | R:R:F309 | R:R:Y313 | 14.44 | 3 | Yes | Yes | 5 | 7 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.88 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/DTR/DTR_7F9Z_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7F9Z_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XAU | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Gi1/Beta1/Gamma2 | 2.97 | 2022-08-31 | 10.1038/s41421-022-00405-2 |
![](/psngpcr/ligands/DTR/DTR_7XAU_L_L_4.png)
A 2D representation of the interactions of DTR in 7XAU colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F92 | R:R:Q126 | 9.37 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:F92 | R:R:Y302 | 27.85 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | L:L:K5 | R:R:L99 | 4.23 | 0 | Yes | No | 0 | 6 | 1 | 2 | R:R:I177 | R:R:M119 | 2.92 | 1 | Yes | No | 3 | 5 | 1 | 2 | R:R:F127 | R:R:Q126 | 9.37 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:Q126 | R:R:W269 | 9.86 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | L:L:?4 | R:R:Q126 | 6.39 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F127 | R:R:T212 | 5.19 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | R:R:F127 | R:R:G216 | 4.52 | 1 | Yes | No | 6 | 6 | 1 | 2 | L:L:?4 | R:R:F127 | 2.93 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I177 | R:R:I195 | 7.36 | 1 | Yes | No | 3 | 5 | 1 | 2 | R:R:F208 | R:R:I177 | 5.02 | 1 | Yes | Yes | 7 | 3 | 1 | 1 | L:L:?4 | R:R:I177 | 4.57 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:F208 | R:R:I195 | 6.28 | 1 | Yes | No | 7 | 5 | 1 | 2 | L:L:F3 | R:R:Y205 | 14.44 | 1 | Yes | No | 0 | 4 | 1 | 2 | R:R:F208 | R:R:I209 | 3.77 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:F208 | R:R:T212 | 5.19 | 1 | Yes | Yes | 7 | 4 | 1 | 1 | L:L:F3 | R:R:F208 | 7.5 | 1 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:?4 | R:R:F208 | 12.68 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I209 | R:R:T212 | 3.04 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:I209 | R:R:N276 | 11.33 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:T212 | R:R:Y273 | 8.74 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?4 | R:R:T212 | 8.26 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F272 | R:R:W269 | 3.01 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | R:R:W269 | R:R:Y273 | 3.86 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:T301 | R:R:W269 | 19.41 | 1 | No | Yes | 7 | 8 | 2 | 2 | R:R:F272 | R:R:N276 | 3.62 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:F272 | R:R:V297 | 3.93 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:F272 | R:R:T301 | 5.19 | 1 | Yes | No | 6 | 7 | 1 | 2 | L:L:?4 | R:R:F272 | 3.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F294 | R:R:N276 | 8.46 | 1 | Yes | Yes | 4 | 6 | 2 | 1 | L:L:?4 | R:R:N276 | 7.7 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:K5 | R:R:V298 | 3.04 | 0 | Yes | No | 0 | 6 | 1 | 2 | R:R:T301 | R:R:Y302 | 3.75 | 1 | No | Yes | 7 | 7 | 2 | 2 | L:L:K5 | R:R:Y302 | 7.17 | 0 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?4 | L:L:F3 | 5.85 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:K5 | 22.58 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:F127 | R:R:V173 | 2.62 | 1 | Yes | No | 6 | 4 | 1 | 2 | L:L:F3 | R:R:V280 | 2.62 | 1 | Yes | No | 0 | 4 | 1 | 2 | R:R:G123 | R:R:Q126 | 1.64 | 0 | No | Yes | 4 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 9.00 | Average Interaction Strength | 8.32 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 40.00 | Average Links Mediated by Hubs In Shell | 40.00 |
| ![](/psngpcr/ligands/DTR/DTR_7XAU_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7XAU_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XAV | A | Peptide | Somatostatin | SST2 | Homo sapiens | Lanreotide | - | Gi1/Beta1/Gamma2 | 2.87 | 2022-08-31 | 10.1038/s41421-022-00405-2 |
![](/psngpcr/ligands/DTR/DTR_7XAV_L_L_4.png)
A 2D representation of the interactions of DTR in 7XAV colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F92 | R:R:Q126 | 17.57 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:F92 | R:R:Y302 | 21.66 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F127 | R:R:Q126 | 7.03 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:Q126 | R:R:W269 | 7.67 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | L:L:?4 | R:R:Q126 | 4.26 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:K5 | R:R:Q126 | 4.07 | 2 | Yes | Yes | 0 | 7 | 1 | 1 | R:R:F127 | R:R:V173 | 3.93 | 2 | Yes | No | 6 | 4 | 1 | 2 | R:R:F127 | R:R:T212 | 3.89 | 2 | Yes | Yes | 6 | 4 | 1 | 1 | R:R:F127 | R:R:G216 | 3.01 | 2 | Yes | No | 6 | 6 | 1 | 2 | L:L:?4 | R:R:F127 | 4.88 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F208 | R:R:I177 | 5.02 | 2 | Yes | No | 7 | 3 | 1 | 2 | R:R:F208 | R:R:W197 | 18.04 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:F208 | R:R:T212 | 3.89 | 2 | Yes | Yes | 7 | 4 | 1 | 1 | L:L:Y3 | R:R:F208 | 9.28 | 2 | Yes | Yes | 0 | 7 | 2 | 1 | L:L:?4 | R:R:F208 | 13.65 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I209 | R:R:N276 | 7.08 | 0 | Yes | No | 5 | 6 | 2 | 1 | L:L:Y3 | R:R:I209 | 6.04 | 2 | Yes | Yes | 0 | 5 | 2 | 2 | R:R:T212 | R:R:Y273 | 6.24 | 2 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?4 | R:R:T212 | 14.16 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:W269 | R:R:Y273 | 4.82 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:T301 | R:R:W269 | 12.13 | 0 | No | Yes | 7 | 8 | 2 | 2 | R:R:F272 | R:R:Y273 | 8.25 | 2 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:F272 | R:R:V298 | 3.93 | 2 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:F272 | R:R:T301 | 6.49 | 2 | Yes | No | 6 | 7 | 1 | 2 | L:L:?4 | R:R:F272 | 5.85 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:K5 | R:R:F272 | 3.72 | 2 | Yes | Yes | 0 | 6 | 1 | 1 | R:R:F294 | R:R:N276 | 4.83 | 0 | Yes | No | 4 | 6 | 2 | 1 | L:L:?4 | R:R:N276 | 5.5 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F294 | R:R:V298 | 5.24 | 0 | Yes | Yes | 4 | 6 | 2 | 2 | L:L:K5 | R:R:V298 | 4.55 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | R:R:T301 | R:R:Y302 | 3.75 | 0 | No | Yes | 7 | 7 | 2 | 2 | L:L:K5 | R:R:Y302 | 5.97 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?4 | L:L:K5 | 19.19 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:K5 | R:R:L99 | 1.41 | 2 | Yes | No | 0 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 9.64 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 34.00 |
| ![](/psngpcr/ligands/DTR/DTR_7XAV_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7XAV_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XNA | A | Peptide | Somatostatin | SST2 | Homo sapiens | CYN154806 | - | - | 2.65 | 2022-08-03 | 10.1038/s41422-022-00679-x |
![](/psngpcr/ligands/DTR/DTR_7XNA_L_L_5.png)
A 2D representation of the interactions of DTR in 7XNA colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:C193 | R:R:M119 | 4.86 | 6 | No | No | 9 | 5 | 2 | 1 | L:L:?5 | R:R:M119 | 5.66 | 0 | Yes | No | 0 | 5 | 0 | 1 | L:L:K6 | R:R:D122 | 11.06 | 0 | No | No | 0 | 6 | 1 | 2 | L:L:K6 | R:R:Q126 | 8.14 | 0 | No | Yes | 0 | 7 | 1 | 2 | R:R:I177 | R:R:I195 | 7.36 | 0 | No | No | 3 | 5 | 2 | 1 | L:L:?5 | R:R:T194 | 8.26 | 0 | Yes | No | 0 | 4 | 0 | 1 | R:R:I195 | R:R:W197 | 15.27 | 0 | No | Yes | 5 | 5 | 1 | 2 | L:L:?5 | R:R:I195 | 8 | 0 | Yes | No | 0 | 5 | 0 | 1 | L:L:?5 | L:L:K6 | 19.19 | 0 | Yes | No | 0 | 0 | 0 | 1 | R:R:A181 | R:R:M119 | 3.22 | 0 | No | No | 4 | 5 | 2 | 1 | R:R:N196 | R:R:T194 | 2.92 | 0 | No | No | 3 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 10.28 | Average Nodes In Shell | 12.00 | Average Hubs In Shell | 3.00 | Average Links In Shell | 11.00 | Average Links Mediated by Hubs In Shell | 6.00 |
| ![](/psngpcr/ligands/DTR/DTR_7XNA_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7XNA_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y24 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Go/Beta1/Gamma2 | 3.25 | 2022-10-19 | 10.1038/s41589-022-01130-3 |
![](/psngpcr/ligands/DTR/DTR_7Y24_L_L_4.png)
A 2D representation of the interactions of DTR in 7Y24 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:C2 | R:R:F294 | 12.57 | 1 | Yes | No | 0 | 4 | 2 | 1 | L:L:?4 | L:L:F3 | 5.85 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:F3 | R:R:I195 | 3.77 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:F3 | R:R:N196 | 7.25 | 1 | Yes | Yes | 0 | 3 | 1 | 2 | L:L:F3 | R:R:Y205 | 7.22 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:F3 | R:R:I209 | 7.54 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:?4 | L:L:K5 | 22.58 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?4 | R:R:Q126 | 7.46 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?4 | R:R:I195 | 5.71 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:T212 | 3.54 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?4 | R:R:F272 | 6.83 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:N276 | 9.89 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:F294 | 5.85 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:K5 | R:R:D122 | 8.3 | 1 | No | No | 0 | 6 | 1 | 2 | L:L:K5 | R:R:Q126 | 8.14 | 1 | No | Yes | 0 | 7 | 1 | 1 | R:R:D122 | R:R:F92 | 7.17 | 1 | No | Yes | 6 | 6 | 2 | 2 | R:R:F92 | R:R:Q126 | 5.86 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:Q126 | R:R:W269 | 10.95 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:I177 | R:R:I195 | 7.36 | 1 | No | Yes | 3 | 5 | 2 | 1 | R:R:F208 | R:R:I177 | 5.02 | 1 | Yes | No | 7 | 3 | 2 | 2 | R:R:I195 | R:R:N196 | 9.91 | 1 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:F208 | R:R:I195 | 3.77 | 1 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:N196 | R:R:Y205 | 4.65 | 1 | Yes | Yes | 3 | 4 | 2 | 2 | R:R:F208 | R:R:N196 | 9.67 | 1 | Yes | Yes | 7 | 3 | 2 | 2 | R:R:F208 | R:R:I209 | 3.77 | 1 | Yes | No | 7 | 5 | 2 | 2 | R:R:F208 | R:R:T212 | 7.78 | 1 | Yes | No | 7 | 4 | 2 | 1 | R:R:I209 | R:R:N276 | 5.66 | 0 | No | No | 5 | 6 | 2 | 1 | R:R:W269 | R:R:Y273 | 4.82 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:F272 | R:R:Y273 | 7.22 | 0 | No | Yes | 6 | 7 | 1 | 2 | R:R:F272 | R:R:V297 | 3.93 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:F294 | R:R:N276 | 7.25 | 1 | No | No | 4 | 6 | 1 | 1 | L:L:F3 | R:R:V280 | 2.62 | 1 | Yes | No | 0 | 4 | 1 | 2 | R:R:F127 | R:R:T212 | 2.59 | 0 | Yes | No | 6 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 8.46 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/DTR/DTR_7Y24_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7Y24_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y26 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.3 | 2022-10-19 | 10.1038/s41589-022-01130-3 |
![](/psngpcr/ligands/DTR/DTR_7Y26_L_L_4.png)
A 2D representation of the interactions of DTR in 7Y26 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:C2 | L:L:C7 | 7.28 | 1 | No | Yes | 0 | 0 | 2 | 2 | L:L:C2 | R:R:F294 | 9.78 | 1 | No | Yes | 0 | 4 | 2 | 1 | L:L:?4 | L:L:F3 | 5.85 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:F3 | R:R:I195 | 8.79 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:F3 | R:R:Y205 | 10.32 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:F3 | R:R:F208 | 2.14 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:F3 | R:R:I209 | 3.77 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:?4 | L:L:K5 | 12.42 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?4 | R:R:Q126 | 2.13 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?4 | R:R:I195 | 5.71 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:F272 | 3.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?4 | R:R:N276 | 4.4 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:F294 | 2.93 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:K5 | R:R:Q126 | 4.07 | 1 | No | Yes | 0 | 7 | 1 | 1 | L:L:C7 | R:R:F294 | 5.59 | 1 | Yes | Yes | 0 | 4 | 2 | 1 | R:R:F127 | R:R:Q126 | 3.51 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:Q126 | R:R:W269 | 5.48 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:I177 | R:R:I195 | 2.94 | 0 | No | Yes | 3 | 5 | 2 | 1 | R:R:F208 | R:R:I195 | 3.77 | 1 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:F208 | R:R:I209 | 3.77 | 1 | Yes | No | 7 | 5 | 2 | 2 | R:R:W269 | R:R:Y273 | 1.93 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:T301 | R:R:W269 | 3.64 | 0 | No | Yes | 7 | 8 | 2 | 2 | R:R:F272 | R:R:Y273 | 8.25 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:F272 | R:R:N276 | 4.83 | 1 | Yes | No | 6 | 6 | 1 | 1 | R:R:F272 | R:R:V297 | 3.93 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F272 | R:R:T301 | 3.89 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F275 | R:R:F294 | 16.08 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:F294 | R:R:N276 | 4.83 | 1 | Yes | No | 4 | 6 | 1 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 5.33 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 28.00 | Average Links Mediated by Hubs In Shell | 28.00 |
| ![](/psngpcr/ligands/DTR/DTR_7Y26_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7Y26_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y27 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.48 | 2022-10-19 | 10.1038/s41589-022-01130-3 |
![](/psngpcr/ligands/DTR/DTR_7Y27_L_L_4.png)
A 2D representation of the interactions of DTR in 7Y27 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:C2 | L:L:C7 | 7.28 | 1 | No | Yes | 0 | 0 | 2 | 2 | L:L:C2 | R:R:F294 | 9.78 | 1 | No | Yes | 0 | 4 | 2 | 1 | L:L:?4 | L:L:F3 | 5.85 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:F3 | R:R:I195 | 8.79 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:F3 | R:R:Y205 | 10.32 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:F3 | R:R:F208 | 2.14 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:F3 | R:R:I209 | 3.77 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:?4 | L:L:K5 | 12.42 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?4 | R:R:Q126 | 2.13 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?4 | R:R:I195 | 5.71 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:F272 | 3.9 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?4 | R:R:N276 | 4.4 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:F294 | 2.93 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:K5 | R:R:Q126 | 4.07 | 1 | No | Yes | 0 | 7 | 1 | 1 | L:L:C7 | R:R:F294 | 5.59 | 1 | Yes | Yes | 0 | 4 | 2 | 1 | R:R:F127 | R:R:Q126 | 3.51 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:Q126 | R:R:W269 | 5.48 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:I177 | R:R:I195 | 2.94 | 0 | No | Yes | 3 | 5 | 2 | 1 | R:R:F208 | R:R:I195 | 3.77 | 1 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:F208 | R:R:I209 | 3.77 | 1 | Yes | No | 7 | 5 | 2 | 2 | R:R:W269 | R:R:Y273 | 1.93 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:T301 | R:R:W269 | 3.64 | 0 | No | Yes | 7 | 8 | 2 | 2 | R:R:F272 | R:R:Y273 | 8.25 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:F272 | R:R:N276 | 4.83 | 1 | Yes | No | 6 | 6 | 1 | 1 | R:R:F272 | R:R:V297 | 3.93 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F272 | R:R:T301 | 3.89 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F275 | R:R:F294 | 16.08 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:F294 | R:R:N276 | 4.83 | 1 | Yes | No | 4 | 6 | 1 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 5.33 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 28.00 | Average Links Mediated by Hubs In Shell | 28.00 |
| ![](/psngpcr/ligands/DTR/DTR_7Y27_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7Y27_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7YAE | A | Peptide | Somatostatin | SST2 | Homo Sapiens | Octreotide | - | Gi1/Beta1/Gamma2 | 3.37 | 2023-04-19 | 10.1038/s41467-023-36673-z |
![](/psngpcr/ligands/DTR/DTR_7YAE_L_L_4.png)
A 2D representation of the interactions of DTR in 7YAE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D122 | R:R:F92 | 11.94 | 4 | No | Yes | 6 | 6 | 2 | 2 | R:R:F92 | R:R:Q126 | 9.37 | 4 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:F92 | R:R:Y302 | 12.38 | 4 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:D122 | R:R:Y302 | 11.49 | 4 | No | Yes | 6 | 7 | 2 | 2 | L:L:K5 | R:R:D122 | 4.15 | 4 | Yes | No | 0 | 6 | 1 | 2 | R:R:Q126 | R:R:W269 | 3.29 | 4 | Yes | Yes | 7 | 8 | 1 | 2 | L:L:?4 | R:R:Q126 | 7.46 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:K5 | R:R:Q126 | 5.42 | 4 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:F3 | R:R:I195 | 3.77 | 4 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:F208 | R:R:W204 | 11.02 | 4 | Yes | Yes | 7 | 3 | 2 | 2 | L:L:F3 | R:R:W204 | 3.01 | 4 | Yes | Yes | 0 | 3 | 1 | 2 | L:L:F3 | R:R:Y205 | 7.22 | 4 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:F3 | R:R:F208 | 5.36 | 4 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:I209 | R:R:N276 | 8.5 | 0 | Yes | No | 5 | 6 | 2 | 1 | R:R:F272 | R:R:Y273 | 5.16 | 0 | No | No | 6 | 7 | 1 | 2 | L:L:?4 | R:R:F272 | 6.83 | 4 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:N276 | 7.7 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:F294 | R:R:V298 | 6.55 | 0 | Yes | No | 4 | 6 | 1 | 2 | L:L:?4 | R:R:F294 | 3.9 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:C7 | R:R:F294 | 2.79 | 19 | Yes | Yes | 0 | 4 | 2 | 1 | L:L:K5 | R:R:Y302 | 3.58 | 4 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?4 | L:L:F3 | 4.88 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:K5 | 23.71 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:F275 | R:R:F294 | 2.14 | 0 | No | Yes | 4 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 9.08 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 24.00 | Average Links Mediated by Hubs In Shell | 23.00 |
| ![](/psngpcr/ligands/DTR/DTR_7YAE_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DTR/DTR_7YAE_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|