CodeDTR
NameD-Tryptophan
Synonyms
  • D-Tryptophan
  • (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
  • (R)-tryptophan
  • DTR
Identifier
FormulaC11 H12 N2 O2
Molecular Weight204.225
SMILES
PubChem6923517
Formal Charge0
Total Atoms27
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds10
Networks32
 missing image

This ligand is also present in the following 32 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F9Z A Peptide Ghrelin Ghrelin Homo Sapiens GHRP-6 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.2 2021-08-18 doi.org/10.1038/s41467-021-25364-2

A 2D representation of the interactions of DTR in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 16.07 0 No Yes 0 0 1 0
L:L:?1 R:R:Y106 10.12 0 No No 0 3 1 2
L:L:?1 R:R:R199 5.24 0 No No 0 3 1 2
L:L:?2 L:L:?3 30.01 3 Yes Yes 0 0 0 1
L:L:?2 L:L:?6 9.47 3 Yes Yes 0 0 0 1
L:L:?2 R:R:D99 5.37 3 Yes No 0 6 0 1
L:L:?2 R:R:L103 8.76 3 Yes No 0 4 0 1
L:L:?2 R:R:Q302 11.59 3 Yes No 0 3 0 1
L:L:?2 R:R:F309 9.64 3 Yes Yes 0 5 0 1
L:L:?3 L:L:?4 17.78 3 Yes Yes 0 0 1 2
L:L:?3 R:R:F286 9.89 3 Yes Yes 0 4 1 2
L:L:?3 R:R:N305 22.29 3 Yes No 0 4 1 2
L:L:?4 L:L:?5 13.89 3 Yes Yes 0 0 2 2
L:L:?4 L:L:?6 9.47 3 Yes Yes 0 0 2 1
L:L:?4 R:R:F286 3.86 3 Yes Yes 0 4 2 2
L:L:?4 R:R:F309 8.67 3 Yes Yes 0 5 2 1
L:L:?5 L:L:?6 28.35 3 Yes Yes 0 0 2 1
L:L:?5 L:L:?7 5.82 3 Yes Yes 0 0 2 2
L:L:?5 R:R:E124 5.6 3 Yes Yes 0 4 2 2
L:L:?6 L:L:?7 23.83 3 Yes Yes 0 0 1 2
L:L:?6 R:R:D99 4.69 3 Yes No 0 6 1 1
L:L:?6 R:R:Q120 21.87 3 Yes Yes 0 4 1 2
L:L:?6 R:R:E124 6.88 3 Yes Yes 0 4 1 2
L:L:?6 R:R:I178 4.94 3 Yes No 0 4 1 2
L:L:?7 R:R:Q120 9.93 3 Yes Yes 0 4 2 2
L:L:?7 R:R:E124 13.19 3 Yes Yes 0 4 2 2
R:R:D99 R:R:F309 9.55 3 No Yes 6 5 1 1
R:R:E124 R:R:I178 6.83 3 Yes No 4 4 2 2
R:R:F309 R:R:Y313 14.44 3 Yes Yes 5 7 1 2
R:R:L306 R:R:Q302 2.66 0 No No 4 3 2 1
R:R:Q302 R:R:Y303 1.13 0 No No 3 1 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength12.99
Average Nodes In Shell21.00
Average Hubs In Shell11.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DTR in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:?3 30.01 3 Yes Yes 0 0 2 1
L:L:?2 L:L:?6 9.47 3 Yes Yes 0 0 2 1
L:L:?2 R:R:D99 5.37 3 Yes No 0 6 2 2
L:L:?2 R:R:F309 9.64 3 Yes Yes 0 5 2 1
L:L:?3 L:L:?4 17.78 3 Yes Yes 0 0 1 0
L:L:?3 R:R:F286 9.89 3 Yes Yes 0 4 1 1
L:L:?3 R:R:N305 22.29 3 Yes No 0 4 1 2
L:L:?4 L:L:?5 13.89 3 Yes Yes 0 0 0 1
L:L:?4 L:L:?6 9.47 3 Yes Yes 0 0 0 1
L:L:?4 R:R:F286 3.86 3 Yes Yes 0 4 0 1
L:L:?4 R:R:S308 4.75 3 Yes No 0 7 0 1
L:L:?4 R:R:F309 8.67 3 Yes Yes 0 5 0 1
L:L:?5 L:L:?6 28.35 3 Yes Yes 0 0 1 1
L:L:?5 L:L:?7 5.82 3 Yes Yes 0 0 1 2
L:L:?5 R:R:E124 5.6 3 Yes Yes 0 4 1 2
L:L:?5 R:R:L181 11.71 3 Yes No 0 4 1 2
L:L:?5 R:R:P200 6.94 3 Yes No 0 4 1 2
L:L:?5 R:R:M213 11.96 3 Yes No 0 5 1 2
L:L:?5 R:R:R283 27.74 3 Yes Yes 0 6 1 2
L:L:?6 L:L:?7 23.83 3 Yes Yes 0 0 1 2
L:L:?6 R:R:D99 4.69 3 Yes No 0 6 1 2
L:L:?6 R:R:Q120 21.87 3 Yes Yes 0 4 1 2
L:L:?6 R:R:E124 6.88 3 Yes Yes 0 4 1 2
L:L:?6 R:R:I178 4.94 3 Yes No 0 4 1 2
L:L:?7 R:R:Q120 9.93 3 Yes Yes 0 4 2 2
L:L:?7 R:R:E124 13.19 3 Yes Yes 0 4 2 2
R:R:D99 R:R:F309 9.55 3 No Yes 6 5 2 1
R:R:E124 R:R:I178 6.83 3 Yes No 4 4 2 2
R:R:E124 R:R:R283 5.82 3 Yes Yes 4 6 2 2
R:R:L181 R:R:M213 7.07 3 No No 4 5 2 2
R:R:P278 R:R:S308 3.56 0 No No 9 7 2 1
R:R:F286 R:R:S289 3.96 3 Yes No 4 2 1 2
R:R:F286 R:R:F290 8.57 3 Yes No 4 1 1 2
R:R:F309 R:R:Y313 14.44 3 Yes Yes 5 7 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.74
Average Nodes In Shell22.00
Average Hubs In Shell12.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7T11 A Peptide Somatostatin SST2 Homo Sapiens Octreotide - Gi3/Beta1/Gamma2 2.7 2022-03-09 doi.org/10.1038/s41594-022-00727-5

A 2D representation of the interactions of DTR in 7T11
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C2 L:L:C7 7.28 1 No Yes 0 0 2 2
L:L:C2 R:R:F294 8.38 1 No Yes 0 4 2 1
L:L:?4 L:L:F3 7.73 1 Yes Yes 0 0 0 1
L:L:F3 R:R:W197 3.01 1 Yes Yes 0 5 1 2
L:L:F3 R:R:Y205 14.44 1 Yes Yes 0 4 1 2
L:L:F3 R:R:F208 2.14 1 Yes Yes 0 7 1 1
L:L:F3 R:R:I209 5.02 1 Yes Yes 0 5 1 2
L:L:?4 L:L:K5 15.67 1 Yes Yes 0 0 0 1
L:L:?4 R:R:I177 3.4 1 Yes No 0 3 0 1
L:L:?4 R:R:I195 2.27 1 Yes No 0 5 0 1
L:L:?4 R:R:F208 1.93 1 Yes Yes 0 7 0 1
L:L:?4 R:R:T212 3.51 1 Yes No 0 4 0 1
L:L:?4 R:R:F272 4.83 1 Yes Yes 0 6 0 1
L:L:?4 R:R:N276 9.81 1 Yes Yes 0 6 0 1
L:L:?4 R:R:F294 2.9 1 Yes Yes 0 4 0 1
L:L:K5 R:R:D122 5.53 1 Yes Yes 0 6 1 2
L:L:K5 R:R:Q126 2.71 1 Yes Yes 0 7 1 2
L:L:K5 R:R:Y302 3.58 1 Yes Yes 0 7 1 2
L:L:C7 R:R:F294 6.98 1 Yes Yes 0 4 2 1
R:R:D122 R:R:Y302 8.05 1 Yes Yes 6 7 2 2
R:R:F208 R:R:I177 3.77 1 Yes No 7 3 1 1
R:R:I195 R:R:W197 4.7 0 No Yes 5 5 1 2
R:R:W197 R:R:Y205 12.54 1 Yes Yes 5 4 2 2
R:R:F208 R:R:W197 11.02 1 Yes Yes 7 5 1 2
R:R:F208 R:R:T212 7.78 1 Yes No 7 4 1 1
R:R:I209 R:R:N276 2.83 0 Yes Yes 5 6 2 1
R:R:F272 R:R:Y273 5.16 1 Yes Yes 6 7 1 2
R:R:F272 R:R:N276 8.46 1 Yes Yes 6 6 1 1
R:R:F272 R:R:T301 5.19 1 Yes No 6 7 1 2
R:R:F275 R:R:F294 8.57 0 No Yes 4 4 2 1
R:R:F294 R:R:N276 3.62 1 Yes Yes 4 6 1 1
R:R:F294 R:R:V298 3.93 1 Yes No 4 6 1 2
R:R:I177 R:R:T120 1.52 1 No No 3 6 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength5.78
Average Nodes In Shell23.00
Average Hubs In Shell15.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XAU A Peptide Somatostatin SST2 Homo Sapiens Octreotide - Gi1/Beta1/Gamma2 2.97 2022-08-31 doi.org/10.1038/s41421-022-00405-2

A 2D representation of the interactions of DTR in 7XAU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?4 L:L:F3 5.78 1 Yes Yes 0 0 0 1
L:L:F3 R:R:Y205 14.44 1 Yes No 0 4 1 2
L:L:F3 R:R:F208 7.5 1 Yes Yes 0 7 1 1
L:L:?4 L:L:K5 22.32 1 Yes Yes 0 0 0 1
L:L:?4 R:R:Q126 6.32 1 Yes Yes 0 7 0 1
L:L:?4 R:R:I177 4.52 1 Yes No 0 3 0 1
L:L:?4 R:R:F208 12.53 1 Yes Yes 0 7 0 1
L:L:?4 R:R:T212 8.16 1 Yes Yes 0 4 0 1
L:L:?4 R:R:F272 3.86 1 Yes Yes 0 6 0 1
L:L:?4 R:R:N276 7.61 1 Yes Yes 0 6 0 1
L:L:K5 R:R:L99 4.23 0 Yes No 0 6 1 2
L:L:K5 R:R:V298 3.04 0 Yes No 0 6 1 2
L:L:K5 R:R:Y302 7.17 0 Yes Yes 0 7 1 2
R:R:F92 R:R:Q126 10.54 1 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 24.76 1 Yes Yes 6 7 2 2
R:R:F127 R:R:Q126 9.37 0 Yes Yes 6 7 2 1
R:R:Q126 R:R:W269 9.86 0 Yes Yes 7 8 1 2
R:R:F127 R:R:T212 5.19 0 Yes Yes 6 4 2 1
R:R:F208 R:R:I177 5.02 1 Yes No 7 3 1 1
R:R:F208 R:R:I209 3.77 1 Yes Yes 7 5 1 2
R:R:F208 R:R:T212 5.19 1 Yes Yes 7 4 1 1
R:R:I209 R:R:T212 3.04 1 Yes Yes 5 4 2 1
R:R:I209 R:R:N276 11.33 1 Yes Yes 5 6 2 1
R:R:T212 R:R:Y273 8.74 1 Yes No 4 7 1 2
R:R:F272 R:R:W269 3.01 1 Yes Yes 6 8 1 2
R:R:W269 R:R:Y273 3.86 1 Yes No 8 7 2 2
R:R:T301 R:R:W269 19.41 1 No Yes 7 8 2 2
R:R:F272 R:R:N276 3.62 1 Yes Yes 6 6 1 1
R:R:F272 R:R:V297 3.93 1 Yes Yes 6 7 1 2
R:R:F272 R:R:T301 5.19 1 Yes No 6 7 1 2
R:R:F294 R:R:N276 8.46 1 Yes Yes 4 6 2 1
R:R:T301 R:R:Y302 3.75 1 No Yes 7 7 2 2
R:R:I177 R:R:M119 2.92 1 No No 3 5 1 2
L:L:F3 R:R:V280 2.62 1 Yes No 0 4 1 2
L:L:F3 R:R:I195 2.51 1 Yes No 0 5 1 2
R:R:G123 R:R:Q126 1.64 0 No Yes 4 7 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.89
Average Nodes In Shell25.00
Average Hubs In Shell15.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XAV A Peptide Somatostatin SST2 Homo Sapiens Lanreotide - Gi1/Beta1/Gamma2 2.87 2022-08-31 doi.org/10.1038/s41421-022-00405-2

A 2D representation of the interactions of DTR in 7XAV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y3 R:R:F208 9.28 0 Yes Yes 0 7 2 1
L:L:Y3 R:R:I209 6.04 0 Yes Yes 0 5 2 2
L:L:?4 L:L:K5 18.97 2 Yes Yes 0 0 0 1
L:L:?4 R:R:Q126 4.21 2 Yes Yes 0 7 0 1
L:L:?4 R:R:F127 4.82 2 Yes Yes 0 6 0 1
L:L:?4 R:R:F208 13.49 2 Yes Yes 0 7 0 1
L:L:?4 R:R:T212 14 2 Yes Yes 0 4 0 1
L:L:?4 R:R:F272 5.78 2 Yes Yes 0 6 0 1
L:L:?4 R:R:N276 5.43 2 Yes No 0 6 0 1
L:L:K5 R:R:Q126 4.07 2 Yes Yes 0 7 1 1
L:L:K5 R:R:F272 3.72 2 Yes Yes 0 6 1 1
L:L:K5 R:R:V298 4.55 2 Yes Yes 0 6 1 2
L:L:K5 R:R:Y302 5.97 2 Yes Yes 0 7 1 2
R:R:F92 R:R:Q126 14.05 2 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 22.69 2 Yes Yes 6 7 2 2
R:R:F127 R:R:Q126 7.03 2 Yes Yes 6 7 1 1
R:R:Q126 R:R:W269 7.67 2 Yes Yes 7 8 1 2
R:R:F127 R:R:V173 3.93 2 Yes No 6 4 1 2
R:R:F127 R:R:T212 3.89 2 Yes Yes 6 4 1 1
R:R:F127 R:R:G216 3.01 2 Yes No 6 6 1 2
R:R:F208 R:R:I177 5.02 2 Yes No 7 3 1 2
R:R:F208 R:R:T212 3.89 2 Yes Yes 7 4 1 1
R:R:I209 R:R:N276 7.08 0 Yes No 5 6 2 1
R:R:T212 R:R:Y273 6.24 2 Yes Yes 4 7 1 2
R:R:W269 R:R:Y273 4.82 2 Yes Yes 8 7 2 2
R:R:T301 R:R:W269 12.13 0 No Yes 7 8 2 2
R:R:F272 R:R:Y273 8.25 2 Yes Yes 6 7 1 2
R:R:F272 R:R:V298 3.93 2 Yes Yes 6 6 1 2
R:R:F272 R:R:T301 6.49 2 Yes No 6 7 1 2
R:R:F294 R:R:N276 4.83 0 Yes No 4 6 2 1
R:R:F294 R:R:V298 5.24 0 Yes Yes 4 6 2 2
R:R:T301 R:R:Y302 3.75 0 No Yes 7 7 2 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.53
Average Nodes In Shell20.00
Average Hubs In Shell15.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XNA A Peptide Somatostatin SST2 Homo Sapiens CYN154806 - - 2.65 2022-08-03 doi.org/10.1038/s41422-022-00679-x

A 2D representation of the interactions of DTR in 7XNA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?5 L:L:K6 18.97 0 Yes No 0 0 0 1
L:L:?5 R:R:M119 5.59 0 Yes No 0 5 0 1
L:L:?5 R:R:T194 8.16 0 Yes No 0 4 0 1
L:L:?5 R:R:I195 7.91 0 Yes No 0 5 0 1
L:L:K6 R:R:D122 11.06 0 No No 0 6 1 2
L:L:K6 R:R:Q126 8.14 0 No Yes 0 7 1 2
R:R:C193 R:R:M119 4.86 6 No No 9 5 2 1
R:R:I177 R:R:I195 7.36 0 No No 3 5 2 1
R:R:I195 R:R:W197 15.27 0 No Yes 5 5 1 2
R:R:A181 R:R:M119 3.22 0 No No 4 5 2 1
R:R:N196 R:R:T194 2.92 0 No No 3 4 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength10.16
Average Nodes In Shell12.00
Average Hubs In Shell3.00
Average Links In Shell11.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y24 A Peptide Somatostatin SST2 Homo Sapiens Octreotide - Go/Beta1/Gamma2 3.25 2022-10-19 doi.org/10.1038/s41589-022-01130-3

A 2D representation of the interactions of DTR in 7Y24
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C2 R:R:F294 12.57 1 Yes Yes 0 4 2 1
L:L:?4 L:L:F3 5.8 1 Yes Yes 0 0 0 1
L:L:F3 R:R:I195 3.77 1 Yes Yes 0 5 1 1
L:L:F3 R:R:N196 7.25 1 Yes Yes 0 3 1 2
L:L:F3 R:R:Y205 7.22 1 Yes Yes 0 4 1 2
L:L:F3 R:R:I209 7.54 1 Yes No 0 5 1 2
L:L:?4 L:L:K5 22.39 1 Yes No 0 0 0 1
L:L:?4 R:R:Q126 7.4 1 Yes Yes 0 7 0 1
L:L:?4 R:R:I195 5.66 1 Yes Yes 0 5 0 1
L:L:?4 R:R:T212 3.51 1 Yes No 0 4 0 1
L:L:?4 R:R:F272 6.77 1 Yes No 0 6 0 1
L:L:?4 R:R:N276 9.81 1 Yes No 0 6 0 1
L:L:?4 R:R:F294 5.8 1 Yes Yes 0 4 0 1
L:L:K5 R:R:D122 8.3 1 No No 0 6 1 2
L:L:K5 R:R:Q126 8.14 1 No Yes 0 7 1 1
R:R:D122 R:R:F92 7.17 1 No Yes 6 6 2 2
R:R:F92 R:R:Q126 5.86 1 Yes Yes 6 7 2 1
R:R:Q126 R:R:W269 10.95 1 Yes Yes 7 8 1 2
R:R:I177 R:R:I195 7.36 1 No Yes 3 5 2 1
R:R:F208 R:R:I177 5.02 1 Yes No 7 3 2 2
R:R:I195 R:R:N196 9.91 1 Yes Yes 5 3 1 2
R:R:F208 R:R:I195 3.77 1 Yes Yes 7 5 2 1
R:R:N196 R:R:Y205 4.65 1 Yes Yes 3 4 2 2
R:R:F208 R:R:N196 9.67 1 Yes Yes 7 3 2 2
R:R:F208 R:R:I209 3.77 1 Yes No 7 5 2 2
R:R:F208 R:R:T212 7.78 1 Yes No 7 4 2 1
R:R:I209 R:R:N276 5.66 0 No No 5 6 2 1
R:R:W269 R:R:Y273 4.82 1 Yes Yes 8 7 2 2
R:R:F272 R:R:Y273 7.22 0 No Yes 6 7 1 2
R:R:F272 R:R:V297 3.93 0 No No 6 7 1 2
R:R:F294 R:R:N276 7.25 1 Yes No 4 6 1 1
L:L:F3 R:R:V280 2.62 1 Yes No 0 4 1 2
R:R:F127 R:R:T212 2.59 0 Yes No 6 4 2 1
R:R:F275 R:R:F294 2.14 0 Yes Yes 4 4 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.39
Average Nodes In Shell23.00
Average Hubs In Shell14.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y26 A Peptide Somatostatin SST2 Homo Sapiens Octreotide - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.3 2022-10-19 doi.org/10.1038/s41589-022-01130-3

A 2D representation of the interactions of DTR in 7Y26
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C2 L:L:C7 7.28 1 No Yes 0 0 2 2
L:L:C2 R:R:F294 9.78 1 No Yes 0 4 2 1
L:L:?4 L:L:F3 5.8 1 Yes Yes 0 0 0 1
L:L:F3 R:R:I195 3.77 1 Yes Yes 0 5 1 2
L:L:F3 R:R:Y205 23.73 1 Yes Yes 0 4 1 2
L:L:F3 R:R:F208 2.14 1 Yes Yes 0 7 1 2
L:L:F3 R:R:I209 3.77 1 Yes Yes 0 5 1 2
L:L:?4 L:L:K5 12.31 1 Yes No 0 0 0 1
L:L:?4 R:R:Q126 2.11 1 Yes Yes 0 7 0 1
L:L:?4 R:R:F272 3.87 1 Yes Yes 0 6 0 1
L:L:?4 R:R:N276 4.36 1 Yes No 0 6 0 1
L:L:?4 R:R:F294 2.9 1 Yes Yes 0 4 0 1
L:L:K5 R:R:Q126 4.07 1 No Yes 0 7 1 1
L:L:C7 R:R:F294 5.59 1 Yes Yes 0 4 2 1
R:R:F127 R:R:Q126 3.51 0 No Yes 6 7 2 1
R:R:Q126 R:R:W269 5.48 1 Yes Yes 7 8 1 2
R:R:F208 R:R:I195 5.02 1 Yes Yes 7 5 2 2
R:R:I209 R:R:Y205 4.84 1 Yes Yes 5 4 2 2
R:R:F208 R:R:I209 3.77 1 Yes Yes 7 5 2 2
R:R:W269 R:R:Y273 1.93 1 Yes Yes 8 7 2 2
R:R:T301 R:R:W269 3.64 0 No Yes 7 8 2 2
R:R:F272 R:R:Y273 8.25 1 Yes Yes 6 7 1 2
R:R:F272 R:R:N276 4.83 1 Yes No 6 6 1 1
R:R:F272 R:R:V297 3.93 1 Yes No 6 7 1 2
R:R:F272 R:R:T301 3.89 1 Yes No 6 7 1 2
R:R:F275 R:R:F294 4.29 0 Yes Yes 4 4 2 1
R:R:F294 R:R:N276 4.83 1 Yes No 4 6 1 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength5.22
Average Nodes In Shell19.00
Average Hubs In Shell13.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y27 A Peptide Somatostatin SST2 Homo Sapiens Somatostatin-14 - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.48 2022-10-19 doi.org/10.1038/s41589-022-01130-3

A 2D representation of the interactions of DTR in 7Y27
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?4 L:L:F3 5.8 0 No No 0 0 0 1
L:L:?4 L:L:K5 12.31 0 No No 0 0 0 1
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub0.00
Average Interaction Strength9.05
Average Nodes In Shell3.00
Average Hubs In Shell0.00
Average Links In Shell2.00
Average Links Mediated by Hubs In Shell0.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YAE A Peptide Somatostatin SST2 Homo Sapiens Octreotide - Gi1/Beta1/Gamma2 3.37 2023-04-19 doi.org/10.1038/s41467-023-36673-z

A 2D representation of the interactions of DTR in 7YAE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D122 R:R:F92 11.94 4 No Yes 6 6 2 2
R:R:F92 R:R:Q126 9.37 4 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 12.38 4 Yes Yes 6 7 2 2
R:R:D122 R:R:Y302 11.49 4 No Yes 6 7 2 2
L:L:K5 R:R:D122 4.15 4 Yes No 0 6 1 2
R:R:Q126 R:R:W269 3.29 4 Yes Yes 7 8 1 2
L:L:?4 R:R:Q126 7.4 4 Yes Yes 0 7 0 1
L:L:K5 R:R:Q126 5.42 4 Yes Yes 0 7 1 1
L:L:F3 R:R:I195 3.77 4 Yes Yes 0 5 1 2
R:R:F208 R:R:W204 11.02 4 Yes Yes 7 3 2 2
L:L:F3 R:R:W204 3.01 4 Yes Yes 0 3 1 2
L:L:F3 R:R:Y205 7.22 4 Yes Yes 0 4 1 2
L:L:F3 R:R:F208 5.36 4 Yes Yes 0 7 1 2
R:R:I209 R:R:N276 8.5 0 Yes No 5 6 2 1
R:R:F272 R:R:Y273 5.16 0 No No 6 7 1 2
L:L:?4 R:R:F272 6.77 4 Yes No 0 6 0 1
L:L:?4 R:R:N276 7.63 4 Yes No 0 6 0 1
R:R:F294 R:R:V298 6.55 0 Yes No 4 6 1 2
L:L:?4 R:R:F294 3.87 4 Yes Yes 0 4 0 1
L:L:C7 R:R:F294 2.79 19 Yes Yes 0 4 2 1
L:L:K5 R:R:Y302 3.58 4 Yes Yes 0 7 1 2
L:L:?4 L:L:F3 4.83 4 Yes Yes 0 0 0 1
L:L:?4 L:L:K5 23.5 4 Yes Yes 0 0 0 1
R:R:F275 R:R:F294 2.14 0 No Yes 4 4 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.00
Average Nodes In Shell20.00
Average Hubs In Shell14.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8X8N A Peptide Somatostatin SST5 Homo Sapiens Octreotide - chim(NtGi1-Gs-CtGi1)/Beta1/Gamma2 2.9 2024-06-12 doi.org/10.1073/pnas.2321710121

A 2D representation of the interactions of DTR in 8X8N
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q123 R:R:Y89 7.89 0 No Yes 7 6 1 2
R:R:F124 R:R:Q123 8.2 0 No No 6 7 2 1
L:L:?4 R:R:Q123 2.11 0 No No 0 7 0 1
L:L:F3 R:R:W190 4.01 0 Yes Yes 0 6 1 2
L:L:F3 R:R:F201 5.36 0 Yes No 0 5 1 2
L:L:F3 R:R:I202 3.77 0 Yes No 0 5 1 2
L:L:K5 R:R:F264 3.72 32 Yes No 0 7 1 2
L:L:K5 R:R:V290 1.52 32 Yes No 0 5 1 2
L:L:T6 R:R:V290 3.17 32 Yes No 0 5 2 2
L:L:?4 L:L:F3 5.78 0 No Yes 0 0 0 1
L:L:?4 L:L:K5 10.04 0 No Yes 0 0 0 1
L:L:K5 L:L:T6 1.5 32 Yes Yes 0 0 1 2
L:L:K5 R:R:D119 1.38 32 Yes No 0 6 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.98
Average Nodes In Shell13.00
Average Hubs In Shell5.00
Average Links In Shell13.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZBE A Peptide Somatostatin SST5 Homo Sapiens Octreotide - Gi1/Beta1/Gamma1 3.24 2024-07-10 doi.org/10.1038/s41401-024-01314-8

A 2D representation of the interactions of DTR in 8ZBE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?4 L:L:F3 5.78 3 Yes Yes 0 0 0 1
L:L:F3 R:R:N187 6.04 3 Yes Yes 0 5 1 1
L:L:F3 R:R:S189 3.96 3 Yes Yes 0 1 1 2
L:L:F3 R:R:G198 4.52 3 Yes No 0 4 1 2
L:L:F3 R:R:I202 3.77 3 Yes No 0 5 1 2
L:L:?4 L:L:K5 32.36 3 Yes No 0 0 0 1
L:L:?4 R:R:M116 7.83 3 Yes Yes 0 5 0 1
L:L:?4 R:R:Q123 3.16 3 Yes Yes 0 7 0 1
L:L:?4 R:R:F124 4.82 3 Yes Yes 0 6 0 1
L:L:?4 R:R:N187 19.56 3 Yes Yes 0 5 0 1
L:L:?4 R:R:T205 4.67 3 Yes Yes 0 4 0 1
L:L:?4 R:R:F264 4.82 3 Yes Yes 0 7 0 1
L:L:K5 R:R:Q123 5.42 3 No Yes 0 7 1 1
L:L:K5 R:R:F264 9.93 3 No Yes 0 7 1 1
L:L:T6 R:R:N187 4.39 0 No Yes 0 5 2 1
R:R:Q123 R:R:Y89 11.27 3 Yes Yes 7 6 1 2
R:R:L174 R:R:M116 7.07 3 Yes Yes 3 5 2 1
R:R:M116 R:R:N187 5.61 3 Yes Yes 5 5 1 1
R:R:M116 R:R:S189 3.07 3 Yes Yes 5 1 1 2
R:R:Q123 R:R:W261 10.95 3 Yes Yes 7 8 1 2
R:R:F265 R:R:Q123 7.03 3 Yes Yes 7 7 2 1
R:R:F124 R:R:S167 3.96 3 Yes No 6 7 1 2
R:R:F124 R:R:M170 11.2 3 Yes Yes 6 4 1 2
R:R:F124 R:R:T205 5.19 3 Yes Yes 6 4 1 1
R:R:M170 R:R:T205 4.52 3 Yes Yes 4 4 2 1
R:R:L174 R:R:S189 4.5 3 Yes Yes 3 1 2 2
R:R:F201 R:R:L174 12.18 3 Yes Yes 5 3 2 2
R:R:F201 R:R:S189 13.21 3 Yes Yes 5 1 2 2
R:R:F201 R:R:I202 5.02 3 Yes No 5 5 2 2
R:R:F201 R:R:T205 7.78 3 Yes Yes 5 4 2 1
R:R:F265 R:R:W261 14.03 3 Yes Yes 7 8 2 2
R:R:F264 R:R:F265 7.5 3 Yes Yes 7 7 1 2
R:R:F264 R:R:N268 4.83 3 Yes No 7 5 1 2
R:R:F264 R:R:V290 3.93 3 Yes No 7 5 1 2
R:R:F264 R:R:S293 7.93 3 Yes No 7 7 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.38
Average Nodes In Shell23.00
Average Hubs In Shell15.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZCJ A Peptide Somatostatin SST5 Homo Sapiens Pasireotide - Gi1/Beta1/Gamma1 3.09 2024-07-10 doi.org/10.1038/s41401-024-01314-8

A 2D representation of the interactions of DTR in 8ZCJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 18.22 1 Yes Yes 0 0 1 0
L:L:?1 L:L:?6 20.99 1 Yes No 0 0 1 2
L:L:?1 R:R:I202 4.52 1 Yes Yes 0 5 1 2
L:L:?1 R:R:N268 7.61 1 Yes Yes 0 5 1 1
L:L:?1 R:R:N271 6.53 1 Yes No 0 4 1 2
L:L:?2 L:L:K3 12.27 1 Yes Yes 0 0 0 1
L:L:?2 R:R:Q123 8.43 1 Yes Yes 0 7 0 1
L:L:?2 R:R:F124 3.86 1 Yes Yes 0 6 0 1
L:L:?2 R:R:F201 3.86 1 Yes Yes 0 5 0 1
L:L:?2 R:R:F264 4.82 1 Yes Yes 0 7 0 1
L:L:?2 R:R:N268 8.69 1 Yes Yes 0 5 0 1
L:L:K3 R:R:Y89 5.97 1 Yes Yes 0 6 1 2
L:L:K3 R:R:D119 13.83 1 Yes No 0 6 1 2
L:L:K3 R:R:F264 8.69 1 Yes Yes 0 7 1 1
L:L:K3 R:R:S293 3.06 1 Yes No 0 7 1 2
L:L:?6 R:R:N271 8.76 1 No No 0 4 2 2
R:R:D119 R:R:Y89 8.05 1 No Yes 6 6 2 2
R:R:Q123 R:R:Y89 6.76 1 Yes Yes 7 6 1 2
R:R:D119 R:R:G120 5.03 1 No No 6 5 2 2
R:R:F124 R:R:G120 3.01 1 Yes No 6 5 1 2
R:R:F124 R:R:Q123 8.2 1 Yes Yes 6 7 1 1
R:R:Q123 R:R:W261 8.76 1 Yes Yes 7 8 1 2
R:R:F265 R:R:Q123 5.86 1 Yes Yes 7 7 2 1
R:R:F124 R:R:M170 7.46 1 Yes No 6 4 1 2
R:R:F124 R:R:T205 3.89 1 Yes No 6 4 1 2
R:R:F201 R:R:L174 7.31 0 Yes No 5 3 1 2
R:R:F201 R:R:I202 3.77 0 Yes Yes 5 5 1 2
R:R:F201 R:R:T205 7.78 0 Yes No 5 4 1 2
R:R:I202 R:R:N268 4.25 1 Yes Yes 5 5 2 1
R:R:F265 R:R:W261 3.01 1 Yes Yes 7 8 2 2
R:R:S293 R:R:W261 3.71 1 No Yes 7 8 2 2
R:R:F264 R:R:F265 5.36 1 Yes Yes 7 7 1 2
R:R:F264 R:R:S293 3.96 1 Yes No 7 7 1 2
R:R:N268 R:R:V267 4.43 1 Yes No 5 5 1 2
R:R:V267 R:R:Y286 11.36 1 No No 5 4 2 2
R:R:N268 R:R:Y286 4.65 1 Yes No 5 4 1 2
R:R:F264 R:R:V289 2.62 1 Yes No 7 7 1 2
L:L:?1 R:R:L272 2.19 1 Yes No 0 4 1 2
R:R:F201 R:R:G198 1.51 0 Yes No 5 4 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.59
Average Nodes In Shell25.00
Average Hubs In Shell12.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IK9 A Peptide Somatostatin SST1 Homo Sapiens SST analogue - Gi1/Beta1/Gamma2 3.37 2025-04-30 doi.org/10.1016/j.apsb.2025.03.043

A 2D representation of the interactions of DTR in 9IK9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 43.71 3 Yes Yes 0 0 2 1
L:L:?1 L:L:?3 5.33 3 Yes Yes 0 0 2 1
L:L:?1 L:L:?6 5.11 3 Yes Yes 0 0 2 1
L:L:?1 L:L:?7 2.08 3 Yes Yes 0 0 2 1
L:L:?1 L:L:?8 14.88 3 Yes Yes 0 0 2 2
L:L:?1 L:L:?9 19.23 3 Yes Yes 0 0 2 2
L:L:?1 R:R:D300 17.41 3 Yes No 0 4 2 2
L:L:?2 L:L:?3 16.61 3 Yes Yes 0 0 1 1
L:L:?2 L:L:?4 3.09 3 Yes Yes 0 0 1 0
L:L:?2 L:L:?6 5.97 3 Yes Yes 0 0 1 1
L:L:?2 L:L:?7 18.26 3 Yes Yes 0 0 1 1
L:L:?2 L:L:?8 3.73 3 Yes Yes 0 0 1 2
L:L:?2 R:R:D300 15.27 3 Yes No 0 4 1 2
L:L:?3 L:L:?4 34.27 3 Yes Yes 0 0 1 0
L:L:?3 L:L:?6 11.21 3 Yes Yes 0 0 1 1
L:L:?3 L:L:?7 2.08 3 Yes Yes 0 0 1 1
L:L:?3 R:R:L220 15.5 3 Yes No 0 5 1 2
L:L:?3 R:R:V224 3.57 3 Yes No 0 5 1 2
L:L:?3 R:R:Q291 2.13 3 Yes Yes 0 6 1 1
L:L:?4 L:L:K5 13.43 3 Yes Yes 0 0 0 1
L:L:?4 L:L:?6 13.15 3 Yes Yes 0 0 0 1
L:L:?4 L:L:?7 6.18 3 Yes Yes 0 0 0 1
L:L:?4 R:R:D137 2.15 3 Yes No 0 6 0 1
L:L:?4 R:R:M141 2.24 3 Yes Yes 0 7 0 1
L:L:?4 R:R:F223 8.7 3 Yes No 0 6 0 1
L:L:?4 R:R:F287 4.83 3 Yes Yes 0 6 0 1
L:L:?4 R:R:Q291 20.07 3 Yes Yes 0 6 0 1
L:L:?4 R:R:S305 2.38 3 Yes No 0 4 0 1
L:L:K5 R:R:L114 2.82 3 Yes No 0 6 1 2
L:L:K5 R:R:D137 5.53 3 Yes No 0 6 1 1
L:L:K5 R:R:F287 4.96 3 Yes Yes 0 6 1 1
L:L:K5 R:R:V309 4.55 3 Yes No 0 5 1 2
L:L:K5 R:R:Y313 7.17 3 Yes Yes 0 7 1 2
L:L:?6 L:L:?7 22.7 3 Yes Yes 0 0 1 1
L:L:?6 L:L:?8 15.87 3 Yes Yes 0 0 1 2
L:L:?6 L:L:?9 3.15 3 Yes Yes 0 0 1 2
L:L:?6 R:R:N209 12.64 3 Yes No 0 5 1 2
L:L:?7 L:L:?8 26.11 3 Yes Yes 0 0 1 2
L:L:?7 L:L:?9 3.21 3 Yes Yes 0 0 1 2
L:L:?7 R:R:S305 8.45 3 Yes No 0 4 1 1
L:L:?8 L:L:?9 22.97 3 Yes Yes 0 0 2 2
R:R:L107 R:R:M141 4.24 0 Yes Yes 7 7 2 1
R:R:L107 R:R:Y313 7.03 0 Yes Yes 7 7 2 2
R:R:D137 R:R:Y313 5.75 3 No Yes 6 7 1 2
R:R:F142 R:R:M141 6.22 0 Yes Yes 6 7 2 1
R:R:M141 R:R:W284 6.98 3 Yes Yes 7 8 1 2
R:R:M141 R:R:Y288 3.59 3 Yes Yes 7 7 1 2
R:R:F223 R:R:I192 5.02 0 No Yes 6 5 1 2
R:R:Q291 R:R:V224 5.73 3 Yes No 6 5 1 2
R:R:W284 R:R:Y288 3.86 3 Yes Yes 8 7 2 2
R:R:F287 R:R:Y288 6.19 3 Yes Yes 6 7 1 2
R:R:F287 R:R:Q291 12.88 3 Yes Yes 6 6 1 1
R:R:F287 R:R:S308 2.64 3 Yes No 6 6 1 2
R:R:V309 R:R:Y313 2.52 3 No Yes 5 7 2 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub8.00
Average Interaction Strength10.04
Average Nodes In Shell28.00
Average Hubs In Shell18.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell54.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9L3Z A Protein Chemerin CML1 Homo Sapiens LRH7-C2 - - 3.9 2025-03-12 doi.org/10.1093/procel/pwae073

A 2D representation of the interactions of DTR in 9L3Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:H1 6.12 1 Yes Yes 0 0 0 1
L:L:H1 R:R:L119 3.86 1 Yes Yes 0 6 1 2
L:L:H1 R:R:R224 11.28 1 Yes Yes 0 5 1 2
L:L:H1 R:R:Y276 8.71 1 Yes Yes 0 6 1 1
L:L:H1 R:R:H277 4.78 1 Yes Yes 0 8 1 2
L:L:H1 R:R:N280 2.55 1 Yes No 0 5 1 2
L:L:?2 R:R:A181 2.5 1 Yes No 0 2 0 1
L:L:?2 R:R:Y276 10.24 1 Yes Yes 0 6 0 1
L:L:?2 R:R:L298 12.08 1 Yes Yes 0 4 0 1
L:L:?2 R:R:A301 11.26 1 Yes No 0 7 0 1
R:R:L119 R:R:S115 3 1 Yes No 6 5 2 2
R:R:A181 R:R:S115 1.71 0 No No 2 5 1 2
R:R:L119 R:R:W273 5.69 1 Yes Yes 6 9 2 2
R:R:L119 R:R:Y276 3.52 1 Yes Yes 6 6 2 1
R:R:A181 R:R:T180 1.68 0 No No 2 4 1 2
R:R:R224 R:R:W273 3 1 Yes Yes 5 9 2 2
R:R:H277 R:R:R224 14.67 1 Yes Yes 8 5 2 2
R:R:W273 R:R:Y276 8.68 1 Yes Yes 9 6 2 1
R:R:H277 R:R:W273 4.23 1 Yes Yes 8 9 2 2
R:R:H277 R:R:Y276 5.44 1 Yes Yes 8 6 2 1
R:R:A301 R:R:Y276 5.34 1 No Yes 7 6 1 1
R:R:G297 R:R:L298 1.71 0 No Yes 5 4 2 1
R:R:L298 R:R:P299 1.64 0 Yes No 4 3 1 2
R:R:L298 R:R:S295 1.5 0 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.44
Average Nodes In Shell16.00
Average Hubs In Shell8.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XIP A Peptide Somatostatin SST1 Homo Sapiens Pasireotide - chim(NtGi1-Gs-CtGi1)/Beta1/Gamma2 3.29 2024-07-03 doi.org/10.1073/pnas.2400298121

A 2D representation of the interactions of DTR in 8XIP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 16.88 3 Yes Yes 0 0 1 0
L:L:?1 L:L:?4 10.1 3 Yes Yes 0 0 1 1
L:L:?1 L:L:?6 21.05 3 Yes Yes 0 0 1 2
L:L:?1 R:R:N209 6.66 3 Yes No 0 5 1 2
L:L:?1 R:R:M210 5.71 3 Yes Yes 0 4 1 1
L:L:?1 R:R:L220 3.36 3 Yes Yes 0 5 1 2
L:L:?2 L:L:K3 27.98 3 Yes Yes 0 0 0 1
L:L:?2 L:L:?4 3.61 3 Yes Yes 0 0 0 1
L:L:?2 R:R:M141 3.37 3 Yes Yes 0 7 0 1
L:L:?2 R:R:M210 7.85 3 Yes Yes 0 4 0 1
L:L:?2 R:R:Q291 7.4 3 Yes No 0 6 0 1
L:L:?4 L:L:K3 4.63 3 Yes Yes 0 0 1 1
L:L:K3 R:R:D137 11.06 3 Yes Yes 0 6 1 2
L:L:K3 R:R:M141 2.88 3 Yes Yes 0 7 1 1
L:L:K3 R:R:Y313 9.55 3 Yes Yes 0 7 1 2
L:L:?4 L:L:?6 4.27 3 Yes Yes 0 0 1 2
L:L:?4 R:R:L114 18.17 3 Yes No 0 6 1 2
L:L:?4 R:R:S117 8.62 3 Yes No 0 6 1 2
L:L:?4 R:R:L134 7.95 3 Yes No 0 5 1 2
L:L:?4 R:R:D137 10.02 3 Yes Yes 0 6 1 2
L:L:?4 R:R:N209 4.51 3 Yes No 0 5 1 2
R:R:D137 R:R:Y313 3.45 3 Yes Yes 6 7 2 2
R:R:I145 R:R:M141 4.37 0 No Yes 7 7 2 1
R:R:M141 R:R:W284 8.14 3 Yes Yes 7 8 1 2
R:R:I192 R:R:M210 2.92 3 No Yes 5 4 2 1
R:R:F223 R:R:I192 10.05 3 No No 6 5 2 2
R:R:F223 R:R:M210 6.22 3 No Yes 6 4 2 1
R:R:F287 R:R:Q291 15.23 0 No No 6 6 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.18
Average Nodes In Shell20.00
Average Hubs In Shell11.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XIR A Peptide Somatostatin SST3 Homo Sapiens Pasireotide - chim(NtGi1-Gs-CtGi1)/Beta1/Gamma2 2.52 2024-07-03 doi.org/10.1073/pnas.2400298121

A 2D representation of the interactions of DTR in 8XIR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 13.32 2 Yes Yes 0 0 1 0
L:L:?1 L:L:?4 9.18 2 Yes Yes 0 0 1 1
L:L:?1 L:L:?6 26.31 2 Yes Yes 0 0 1 2
L:L:?1 R:R:H192 6.24 2 Yes No 0 4 1 2
L:L:?1 R:R:W195 11.97 2 Yes Yes 0 6 1 2
L:L:?1 R:R:R203 11.79 2 Yes Yes 0 4 1 2
L:L:?2 L:L:K3 22.39 2 Yes Yes 0 0 0 1
L:L:?2 L:L:?4 4.51 2 Yes Yes 0 0 0 1
L:L:?2 R:R:M120 3.37 2 Yes Yes 0 4 0 1
L:L:?2 R:R:D123 3.23 2 Yes Yes 0 6 0 1
L:L:?2 R:R:Q127 6.34 2 Yes Yes 0 7 0 1
L:L:?2 R:R:M193 6.73 2 Yes Yes 0 4 0 1
L:L:?2 R:R:T210 4.68 2 Yes No 0 5 0 1
L:L:?2 R:R:F273 7.73 2 Yes Yes 0 6 0 1
L:L:?2 R:R:N277 3.27 2 Yes No 0 6 0 1
L:L:K3 R:R:D123 12.44 2 Yes Yes 0 6 1 1
L:L:K3 R:R:Q127 4.07 2 Yes Yes 0 7 1 1
L:L:K3 R:R:F273 6.2 2 Yes Yes 0 6 1 1
L:L:K3 R:R:V299 3.04 2 Yes No 0 5 1 2
L:L:?4 L:L:?6 9.61 2 Yes Yes 0 0 1 2
L:L:?4 R:R:L100 14.76 2 Yes Yes 0 7 1 2
L:L:?4 R:R:Q103 9.83 2 Yes No 0 5 1 2
L:L:?4 R:R:W109 4.67 2 Yes Yes 0 8 1 2
L:L:?4 R:R:V119 13.44 2 Yes No 0 5 1 2
L:L:?4 R:R:M120 4.64 2 Yes Yes 0 4 1 1
L:L:?4 R:R:D123 6.68 2 Yes Yes 0 6 1 1
L:L:?4 R:R:C191 2.6 2 Yes No 0 9 1 2
R:R:F93 R:R:Q127 7.03 0 Yes Yes 7 7 2 1
R:R:Q103 R:R:W109 4.38 2 No Yes 5 8 2 2
R:R:C191 R:R:W109 11.75 2 No Yes 9 8 2 2
R:R:M120 R:R:V178 3.04 2 Yes No 4 4 1 2
R:R:M120 R:R:S182 6.13 2 Yes No 4 5 1 2
R:R:M120 R:R:M193 8.66 2 Yes Yes 4 4 1 1
R:R:D123 R:R:G124 5.03 2 Yes No 6 4 1 2
R:R:I131 R:R:Q127 4.12 2 Yes Yes 8 7 2 1
R:R:Q127 R:R:W270 10.95 2 Yes Yes 7 8 1 2
R:R:Q127 R:R:Y274 7.89 2 Yes Yes 7 8 1 2
R:R:F128 R:R:T210 2.59 17 Yes No 6 5 2 1
R:R:I131 R:R:W270 9.4 2 Yes Yes 8 8 2 2
R:R:M193 R:R:V178 9.13 2 Yes No 4 4 1 2
R:R:M193 R:R:W195 5.82 2 Yes Yes 4 6 1 2
R:R:R203 R:R:W195 8 2 Yes Yes 4 6 2 2
R:R:I207 R:R:N277 14.16 0 No No 5 6 2 1
R:R:W270 R:R:Y274 12.54 2 Yes Yes 8 8 2 2
R:R:P302 R:R:W270 6.76 0 No Yes 7 8 2 2
R:R:F273 R:R:Y274 11.35 2 Yes Yes 6 8 1 2
R:R:F273 R:R:V299 2.62 2 Yes No 6 5 1 2
R:R:F273 R:R:P302 8.67 2 Yes No 6 7 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub8.00
Average Interaction Strength7.56
Average Nodes In Shell31.00
Average Hubs In Shell19.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IK8 A Peptide Somatostatin SST1 Homo Sapiens SST analogue - Gi1/Beta1/Gamma2 2.82 2025-04-30 doi.org/10.1016/j.apsb.2025.03.043

A 2D representation of the interactions of DTR in 9IK8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:K2 26.86 2 Yes Yes 0 0 0 1
L:L:?1 L:L:?6 16.88 2 Yes Yes 0 0 0 1
L:L:?1 R:R:M141 5.61 2 Yes No 0 7 0 1
L:L:?1 R:R:F142 3.87 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F223 3.87 2 Yes No 0 6 0 1
L:L:?1 R:R:T227 5.85 2 Yes No 0 5 0 1
L:L:?1 R:R:F287 7.73 2 Yes Yes 0 6 0 1
L:L:?1 R:R:Q291 17.96 2 Yes No 0 6 0 1
L:L:?3 L:L:K2 19.67 2 Yes Yes 0 0 2 1
L:L:K2 R:R:L114 4.23 2 Yes Yes 0 6 1 2
L:L:K2 R:R:F287 4.96 2 Yes Yes 0 6 1 1
L:L:?3 L:L:?4 16.98 2 Yes Yes 0 0 2 2
L:L:?3 R:R:L114 28.39 2 Yes Yes 0 6 2 2
L:L:?4 L:L:?5 57.37 2 Yes No 0 0 2 2
L:L:?4 L:L:?6 10.57 2 Yes Yes 0 0 2 1
L:L:?5 L:L:?6 24.21 2 No Yes 0 0 2 1
L:L:?6 R:R:L220 15.67 2 Yes No 0 5 1 2
L:L:?6 R:R:V224 12.04 2 Yes No 0 5 1 2
L:L:?6 R:R:V295 9.63 2 Yes No 0 4 1 2
R:R:F142 R:R:M141 6.22 2 Yes No 6 7 1 1
R:R:M141 R:R:W284 9.31 2 No Yes 7 8 1 2
R:R:F142 R:R:S185 5.28 2 Yes No 6 8 1 2
R:R:F142 R:R:V188 6.55 2 Yes No 6 5 1 2
R:R:F142 R:R:I189 5.02 2 Yes Yes 6 7 1 2
R:R:F142 R:R:T227 9.08 2 Yes No 6 5 1 1
R:R:F223 R:R:I192 5.02 0 No No 6 5 1 2
R:R:Q291 R:R:V224 4.3 2 No No 6 5 1 2
R:R:T227 R:R:Y288 4.99 2 No Yes 5 7 1 2
R:R:W284 R:R:Y288 8.68 2 Yes Yes 8 7 2 2
R:R:F287 R:R:Y288 3.09 2 Yes Yes 6 7 1 2
R:R:F287 R:R:Q291 12.88 2 Yes No 6 6 1 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.08
Average Nodes In Shell22.00
Average Hubs In Shell11.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.62
Average Number Of Links With An Hub4.59
Average Interaction Strength9.15
Average Nodes In Shell20.24
Average Hubs In Shell11.32
Average Links In Shell29.21
Average Links Mediated by Hubs In Shell27.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)