CodeDTR
NameD-Tryptophan
Synonyms
  • D-Tryptophan
  • (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
  • DTR
  • (R)-tryptophan
Identifier(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
FormulaC11 H12 N2 O2
Molecular Weight204.225
SMILESc1ccc2c(c1)c(c[nH]2)C[C@H](C(=O)O)N
PubChem6923517
Formal Charge0
Total Atoms27
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds10
Networks8
 missing image

This ligand is also present in the following 8 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F9Z A Peptide Ghrelin Ghrelin Homo sapiens GHRP-6 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.2 2021-08-18 10.1038/s41467-021-25364-2

A 2D representation of the interactions of DTR in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 16.25 0 No Yes 0 0 1 0
L:L:?1 R:R:Y106 10.11 0 No No 0 3 1 2
L:L:?1 R:R:R199 5.24 0 No No 0 3 1 2
L:L:?2 L:L:?3 30.44 3 Yes Yes 0 0 0 1
L:L:?2 L:L:?6 9.62 3 Yes Yes 0 0 0 1
L:L:?2 R:R:D99 5.43 3 Yes No 0 6 0 1
L:L:?2 R:R:L103 8.87 3 Yes No 0 4 0 1
L:L:?2 R:R:Q302 11.72 3 Yes No 0 3 0 1
L:L:?2 R:R:F309 9.75 3 Yes Yes 0 5 0 1
L:L:?3 L:L:?4 18.04 3 Yes Yes 0 0 1 2
L:L:?3 R:R:F286 9.91 3 Yes Yes 0 4 1 2
L:L:?3 R:R:N305 22.35 3 Yes No 0 4 1 2
L:L:?4 L:L:?5 14.15 3 Yes Yes 0 0 2 2
L:L:?4 L:L:?6 9.62 3 Yes Yes 0 0 2 1
L:L:?4 R:R:F286 3.9 3 Yes Yes 0 4 2 2
L:L:?4 R:R:F309 8.78 3 Yes Yes 0 5 2 1
L:L:?5 L:L:?6 28.63 3 Yes Yes 0 0 2 1
L:L:?5 L:L:?7 5.87 3 Yes Yes 0 0 2 2
L:L:?5 R:R:E124 5.64 3 Yes Yes 0 4 2 2
L:L:?6 L:L:?7 23.95 3 Yes Yes 0 0 1 2
L:L:?6 R:R:D99 4.71 3 Yes No 0 6 1 1
L:L:?6 R:R:Q120 21.95 3 Yes Yes 0 4 1 2
L:L:?6 R:R:E124 6.9 3 Yes Yes 0 4 1 2
L:L:?6 R:R:I178 4.95 3 Yes No 0 4 1 2
L:L:?7 R:R:Q120 9.95 3 Yes Yes 0 4 2 2
L:L:?7 R:R:E124 13.21 3 Yes Yes 0 4 2 2
R:R:D99 R:R:F309 9.55 3 No Yes 6 5 1 1
R:R:E124 R:R:I178 6.83 3 Yes No 4 4 2 2
R:R:F309 R:R:Y313 14.44 3 Yes Yes 5 7 1 2
R:R:L306 R:R:Q302 2.66 0 No No 4 3 2 1
R:R:Q302 R:R:Y303 1.13 0 No No 3 1 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength13.15
Average Nodes In Shell21.00
Average Hubs In Shell11.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DTR in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:?3 30.44 3 Yes Yes 0 0 2 1
L:L:?2 L:L:?6 9.62 3 Yes Yes 0 0 2 1
L:L:?2 R:R:D99 5.43 3 Yes No 0 6 2 2
L:L:?2 R:R:F309 9.75 3 Yes Yes 0 5 2 1
L:L:?3 L:L:?4 18.04 3 Yes Yes 0 0 1 0
L:L:?3 R:R:F286 9.91 3 Yes Yes 0 4 1 1
L:L:?3 R:R:N305 22.35 3 Yes No 0 4 1 2
L:L:?4 L:L:?5 14.15 3 Yes Yes 0 0 0 1
L:L:?4 L:L:?6 9.62 3 Yes Yes 0 0 0 1
L:L:?4 R:R:F286 3.9 3 Yes Yes 0 4 0 1
L:L:?4 R:R:S308 4.81 3 Yes No 0 7 0 1
L:L:?4 R:R:F309 8.78 3 Yes Yes 0 5 0 1
L:L:?5 L:L:?6 28.63 3 Yes Yes 0 0 1 1
L:L:?5 L:L:?7 5.87 3 Yes Yes 0 0 1 2
L:L:?5 R:R:E124 5.64 3 Yes Yes 0 4 1 2
L:L:?5 R:R:L181 11.78 3 Yes No 0 4 1 2
L:L:?5 R:R:P200 6.99 3 Yes No 0 4 1 2
L:L:?5 R:R:M213 12.03 3 Yes No 0 5 1 2
L:L:?5 R:R:R283 27.92 3 Yes Yes 0 6 1 2
L:L:?6 L:L:?7 23.95 3 Yes Yes 0 0 1 2
L:L:?6 R:R:D99 4.71 3 Yes No 0 6 1 2
L:L:?6 R:R:Q120 21.95 3 Yes Yes 0 4 1 2
L:L:?6 R:R:E124 6.9 3 Yes Yes 0 4 1 2
L:L:?6 R:R:I178 4.95 3 Yes No 0 4 1 2
L:L:?7 R:R:Q120 9.95 3 Yes Yes 0 4 2 2
L:L:?7 R:R:E124 13.21 3 Yes Yes 0 4 2 2
R:R:D99 R:R:F309 9.55 3 No Yes 6 5 2 1
R:R:E124 R:R:I178 6.83 3 Yes No 4 4 2 2
R:R:E124 R:R:R283 5.82 3 Yes Yes 4 6 2 2
R:R:L181 R:R:M213 7.07 3 No No 4 5 2 2
R:R:P278 R:R:S308 3.56 0 No No 9 7 2 1
R:R:F286 R:R:S289 3.96 3 Yes No 4 2 1 2
R:R:F286 R:R:F290 8.57 3 Yes No 4 1 1 2
R:R:F309 R:R:Y313 14.44 3 Yes Yes 5 7 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.88
Average Nodes In Shell22.00
Average Hubs In Shell12.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XAU A Peptide Somatostatin SST2 Homo sapiens Octreotide - Gi1/Beta1/Gamma2 2.97 2022-08-31 10.1038/s41421-022-00405-2

A 2D representation of the interactions of DTR in 7XAU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F92 R:R:Q126 9.37 1 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 27.85 1 Yes Yes 6 7 2 2
L:L:K5 R:R:L99 4.23 0 Yes No 0 6 1 2
R:R:I177 R:R:M119 2.92 1 Yes No 3 5 1 2
R:R:F127 R:R:Q126 9.37 1 Yes Yes 6 7 1 1
R:R:Q126 R:R:W269 9.86 1 Yes Yes 7 8 1 2
L:L:?4 R:R:Q126 6.39 1 Yes Yes 0 7 0 1
R:R:F127 R:R:T212 5.19 1 Yes Yes 6 4 1 1
R:R:F127 R:R:G216 4.52 1 Yes No 6 6 1 2
L:L:?4 R:R:F127 2.93 1 Yes Yes 0 6 0 1
R:R:I177 R:R:I195 7.36 1 Yes No 3 5 1 2
R:R:F208 R:R:I177 5.02 1 Yes Yes 7 3 1 1
L:L:?4 R:R:I177 4.57 1 Yes Yes 0 3 0 1
R:R:F208 R:R:I195 6.28 1 Yes No 7 5 1 2
L:L:F3 R:R:Y205 14.44 1 Yes No 0 4 1 2
R:R:F208 R:R:I209 3.77 1 Yes Yes 7 5 1 2
R:R:F208 R:R:T212 5.19 1 Yes Yes 7 4 1 1
L:L:F3 R:R:F208 7.5 1 Yes Yes 0 7 1 1
L:L:?4 R:R:F208 12.68 1 Yes Yes 0 7 0 1
R:R:I209 R:R:T212 3.04 1 Yes Yes 5 4 2 1
R:R:I209 R:R:N276 11.33 1 Yes Yes 5 6 2 1
R:R:T212 R:R:Y273 8.74 1 Yes Yes 4 7 1 2
L:L:?4 R:R:T212 8.26 1 Yes Yes 0 4 0 1
R:R:F272 R:R:W269 3.01 1 Yes Yes 6 8 1 2
R:R:W269 R:R:Y273 3.86 1 Yes Yes 8 7 2 2
R:R:T301 R:R:W269 19.41 1 No Yes 7 8 2 2
R:R:F272 R:R:N276 3.62 1 Yes Yes 6 6 1 1
R:R:F272 R:R:V297 3.93 1 Yes Yes 6 7 1 2
R:R:F272 R:R:T301 5.19 1 Yes No 6 7 1 2
L:L:?4 R:R:F272 3.9 1 Yes Yes 0 6 0 1
R:R:F294 R:R:N276 8.46 1 Yes Yes 4 6 2 1
L:L:?4 R:R:N276 7.7 1 Yes Yes 0 6 0 1
L:L:K5 R:R:V298 3.04 0 Yes No 0 6 1 2
R:R:T301 R:R:Y302 3.75 1 No Yes 7 7 2 2
L:L:K5 R:R:Y302 7.17 0 Yes Yes 0 7 1 2
L:L:?4 L:L:F3 5.85 1 Yes Yes 0 0 0 1
L:L:?4 L:L:K5 22.58 1 Yes Yes 0 0 0 1
R:R:F127 R:R:V173 2.62 1 Yes No 6 4 1 2
L:L:F3 R:R:V280 2.62 1 Yes No 0 4 1 2
R:R:G123 R:R:Q126 1.64 0 No Yes 4 7 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub9.00
Average Interaction Strength8.32
Average Nodes In Shell27.00
Average Hubs In Shell17.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XAV A Peptide Somatostatin SST2 Homo sapiens Lanreotide - Gi1/Beta1/Gamma2 2.87 2022-08-31 10.1038/s41421-022-00405-2

A 2D representation of the interactions of DTR in 7XAV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F92 R:R:Q126 17.57 2 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 21.66 2 Yes Yes 6 7 2 2
R:R:F127 R:R:Q126 7.03 2 Yes Yes 6 7 1 1
R:R:Q126 R:R:W269 7.67 2 Yes Yes 7 8 1 2
L:L:?4 R:R:Q126 4.26 2 Yes Yes 0 7 0 1
L:L:K5 R:R:Q126 4.07 2 Yes Yes 0 7 1 1
R:R:F127 R:R:V173 3.93 2 Yes No 6 4 1 2
R:R:F127 R:R:T212 3.89 2 Yes Yes 6 4 1 1
R:R:F127 R:R:G216 3.01 2 Yes No 6 6 1 2
L:L:?4 R:R:F127 4.88 2 Yes Yes 0 6 0 1
R:R:F208 R:R:I177 5.02 2 Yes No 7 3 1 2
R:R:F208 R:R:W197 18.04 2 Yes Yes 7 5 1 2
R:R:F208 R:R:T212 3.89 2 Yes Yes 7 4 1 1
L:L:Y3 R:R:F208 9.28 2 Yes Yes 0 7 2 1
L:L:?4 R:R:F208 13.65 2 Yes Yes 0 7 0 1
R:R:I209 R:R:N276 7.08 0 Yes No 5 6 2 1
L:L:Y3 R:R:I209 6.04 2 Yes Yes 0 5 2 2
R:R:T212 R:R:Y273 6.24 2 Yes Yes 4 7 1 2
L:L:?4 R:R:T212 14.16 2 Yes Yes 0 4 0 1
R:R:W269 R:R:Y273 4.82 2 Yes Yes 8 7 2 2
R:R:T301 R:R:W269 12.13 0 No Yes 7 8 2 2
R:R:F272 R:R:Y273 8.25 2 Yes Yes 6 7 1 2
R:R:F272 R:R:V298 3.93 2 Yes Yes 6 6 1 2
R:R:F272 R:R:T301 6.49 2 Yes No 6 7 1 2
L:L:?4 R:R:F272 5.85 2 Yes Yes 0 6 0 1
L:L:K5 R:R:F272 3.72 2 Yes Yes 0 6 1 1
R:R:F294 R:R:N276 4.83 0 Yes No 4 6 2 1
L:L:?4 R:R:N276 5.5 2 Yes No 0 6 0 1
R:R:F294 R:R:V298 5.24 0 Yes Yes 4 6 2 2
L:L:K5 R:R:V298 4.55 2 Yes Yes 0 6 1 2
R:R:T301 R:R:Y302 3.75 0 No Yes 7 7 2 2
L:L:K5 R:R:Y302 5.97 2 Yes Yes 0 7 1 2
L:L:?4 L:L:K5 19.19 2 Yes Yes 0 0 0 1
L:L:K5 R:R:L99 1.41 2 Yes No 0 6 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.64
Average Nodes In Shell22.00
Average Hubs In Shell16.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XNA A Peptide Somatostatin SST2 Homo sapiens CYN154806 - - 2.65 2022-08-03 10.1038/s41422-022-00679-x

A 2D representation of the interactions of DTR in 7XNA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C193 R:R:M119 4.86 6 No No 9 5 2 1
L:L:?5 R:R:M119 5.66 0 Yes No 0 5 0 1
L:L:K6 R:R:D122 11.06 0 No No 0 6 1 2
L:L:K6 R:R:Q126 8.14 0 No Yes 0 7 1 2
R:R:I177 R:R:I195 7.36 0 No No 3 5 2 1
L:L:?5 R:R:T194 8.26 0 Yes No 0 4 0 1
R:R:I195 R:R:W197 15.27 0 No Yes 5 5 1 2
L:L:?5 R:R:I195 8 0 Yes No 0 5 0 1
L:L:?5 L:L:K6 19.19 0 Yes No 0 0 0 1
R:R:A181 R:R:M119 3.22 0 No No 4 5 2 1
R:R:N196 R:R:T194 2.92 0 No No 3 4 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength10.28
Average Nodes In Shell12.00
Average Hubs In Shell3.00
Average Links In Shell11.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y24 A Peptide Somatostatin SST2 Homo sapiens Octreotide - Go/Beta1/Gamma2 3.25 2022-10-19 10.1038/s41589-022-01130-3

A 2D representation of the interactions of DTR in 7Y24
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C2 R:R:F294 12.57 1 Yes No 0 4 2 1
L:L:?4 L:L:F3 5.85 1 Yes Yes 0 0 0 1
L:L:F3 R:R:I195 3.77 1 Yes Yes 0 5 1 1
L:L:F3 R:R:N196 7.25 1 Yes Yes 0 3 1 2
L:L:F3 R:R:Y205 7.22 1 Yes Yes 0 4 1 2
L:L:F3 R:R:I209 7.54 1 Yes No 0 5 1 2
L:L:?4 L:L:K5 22.58 1 Yes No 0 0 0 1
L:L:?4 R:R:Q126 7.46 1 Yes Yes 0 7 0 1
L:L:?4 R:R:I195 5.71 1 Yes Yes 0 5 0 1
L:L:?4 R:R:T212 3.54 1 Yes No 0 4 0 1
L:L:?4 R:R:F272 6.83 1 Yes No 0 6 0 1
L:L:?4 R:R:N276 9.89 1 Yes No 0 6 0 1
L:L:?4 R:R:F294 5.85 1 Yes No 0 4 0 1
L:L:K5 R:R:D122 8.3 1 No No 0 6 1 2
L:L:K5 R:R:Q126 8.14 1 No Yes 0 7 1 1
R:R:D122 R:R:F92 7.17 1 No Yes 6 6 2 2
R:R:F92 R:R:Q126 5.86 1 Yes Yes 6 7 2 1
R:R:Q126 R:R:W269 10.95 1 Yes Yes 7 8 1 2
R:R:I177 R:R:I195 7.36 1 No Yes 3 5 2 1
R:R:F208 R:R:I177 5.02 1 Yes No 7 3 2 2
R:R:I195 R:R:N196 9.91 1 Yes Yes 5 3 1 2
R:R:F208 R:R:I195 3.77 1 Yes Yes 7 5 2 1
R:R:N196 R:R:Y205 4.65 1 Yes Yes 3 4 2 2
R:R:F208 R:R:N196 9.67 1 Yes Yes 7 3 2 2
R:R:F208 R:R:I209 3.77 1 Yes No 7 5 2 2
R:R:F208 R:R:T212 7.78 1 Yes No 7 4 2 1
R:R:I209 R:R:N276 5.66 0 No No 5 6 2 1
R:R:W269 R:R:Y273 4.82 1 Yes Yes 8 7 2 2
R:R:F272 R:R:Y273 7.22 0 No Yes 6 7 1 2
R:R:F272 R:R:V297 3.93 0 No No 6 7 1 2
R:R:F294 R:R:N276 7.25 1 No No 4 6 1 1
L:L:F3 R:R:V280 2.62 1 Yes No 0 4 1 2
R:R:F127 R:R:T212 2.59 0 Yes No 6 4 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.46
Average Nodes In Shell22.00
Average Hubs In Shell12.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y26 A Peptide Somatostatin SST2 Homo sapiens Octreotide - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.3 2022-10-19 10.1038/s41589-022-01130-3

A 2D representation of the interactions of DTR in 7Y26
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C2 L:L:C7 7.28 1 No Yes 0 0 2 2
L:L:C2 R:R:F294 9.78 1 No Yes 0 4 2 1
L:L:?4 L:L:F3 5.85 1 Yes Yes 0 0 0 1
L:L:F3 R:R:I195 8.79 1 Yes Yes 0 5 1 1
L:L:F3 R:R:Y205 10.32 1 Yes No 0 4 1 2
L:L:F3 R:R:F208 2.14 1 Yes Yes 0 7 1 2
L:L:F3 R:R:I209 3.77 1 Yes No 0 5 1 2
L:L:?4 L:L:K5 12.42 1 Yes No 0 0 0 1
L:L:?4 R:R:Q126 2.13 1 Yes Yes 0 7 0 1
L:L:?4 R:R:I195 5.71 1 Yes Yes 0 5 0 1
L:L:?4 R:R:F272 3.9 1 Yes Yes 0 6 0 1
L:L:?4 R:R:N276 4.4 1 Yes No 0 6 0 1
L:L:?4 R:R:F294 2.93 1 Yes Yes 0 4 0 1
L:L:K5 R:R:Q126 4.07 1 No Yes 0 7 1 1
L:L:C7 R:R:F294 5.59 1 Yes Yes 0 4 2 1
R:R:F127 R:R:Q126 3.51 0 No Yes 6 7 2 1
R:R:Q126 R:R:W269 5.48 1 Yes Yes 7 8 1 2
R:R:I177 R:R:I195 2.94 0 No Yes 3 5 2 1
R:R:F208 R:R:I195 3.77 1 Yes Yes 7 5 2 1
R:R:F208 R:R:I209 3.77 1 Yes No 7 5 2 2
R:R:W269 R:R:Y273 1.93 1 Yes Yes 8 7 2 2
R:R:T301 R:R:W269 3.64 0 No Yes 7 8 2 2
R:R:F272 R:R:Y273 8.25 1 Yes Yes 6 7 1 2
R:R:F272 R:R:N276 4.83 1 Yes No 6 6 1 1
R:R:F272 R:R:V297 3.93 1 Yes No 6 7 1 2
R:R:F272 R:R:T301 3.89 1 Yes No 6 7 1 2
R:R:F275 R:R:F294 16.08 0 No Yes 4 4 2 1
R:R:F294 R:R:N276 4.83 1 Yes No 4 6 1 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.33
Average Nodes In Shell20.00
Average Hubs In Shell10.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y27 A Peptide Somatostatin SST2 Homo sapiens Somatostatin-14 - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.48 2022-10-19 10.1038/s41589-022-01130-3

A 2D representation of the interactions of DTR in 7Y27
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C2 L:L:C7 7.28 1 No Yes 0 0 2 2
L:L:C2 R:R:F294 9.78 1 No Yes 0 4 2 1
L:L:?4 L:L:F3 5.85 1 Yes Yes 0 0 0 1
L:L:F3 R:R:I195 8.79 1 Yes Yes 0 5 1 1
L:L:F3 R:R:Y205 10.32 1 Yes No 0 4 1 2
L:L:F3 R:R:F208 2.14 1 Yes Yes 0 7 1 2
L:L:F3 R:R:I209 3.77 1 Yes No 0 5 1 2
L:L:?4 L:L:K5 12.42 1 Yes No 0 0 0 1
L:L:?4 R:R:Q126 2.13 1 Yes Yes 0 7 0 1
L:L:?4 R:R:I195 5.71 1 Yes Yes 0 5 0 1
L:L:?4 R:R:F272 3.9 1 Yes Yes 0 6 0 1
L:L:?4 R:R:N276 4.4 1 Yes No 0 6 0 1
L:L:?4 R:R:F294 2.93 1 Yes Yes 0 4 0 1
L:L:K5 R:R:Q126 4.07 1 No Yes 0 7 1 1
L:L:C7 R:R:F294 5.59 1 Yes Yes 0 4 2 1
R:R:F127 R:R:Q126 3.51 0 No Yes 6 7 2 1
R:R:Q126 R:R:W269 5.48 1 Yes Yes 7 8 1 2
R:R:I177 R:R:I195 2.94 0 No Yes 3 5 2 1
R:R:F208 R:R:I195 3.77 1 Yes Yes 7 5 2 1
R:R:F208 R:R:I209 3.77 1 Yes No 7 5 2 2
R:R:W269 R:R:Y273 1.93 1 Yes Yes 8 7 2 2
R:R:T301 R:R:W269 3.64 0 No Yes 7 8 2 2
R:R:F272 R:R:Y273 8.25 1 Yes Yes 6 7 1 2
R:R:F272 R:R:N276 4.83 1 Yes No 6 6 1 1
R:R:F272 R:R:V297 3.93 1 Yes No 6 7 1 2
R:R:F272 R:R:T301 3.89 1 Yes No 6 7 1 2
R:R:F275 R:R:F294 16.08 0 No Yes 4 4 2 1
R:R:F294 R:R:N276 4.83 1 Yes No 4 6 1 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.33
Average Nodes In Shell20.00
Average Hubs In Shell10.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YAE A Peptide Somatostatin SST2 Homo Sapiens Octreotide - Gi1/Beta1/Gamma2 3.37 2023-04-19  10.1038/s41467-023-36673-z

A 2D representation of the interactions of DTR in 7YAE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D122 R:R:F92 11.94 4 No Yes 6 6 2 2
R:R:F92 R:R:Q126 9.37 4 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 12.38 4 Yes Yes 6 7 2 2
R:R:D122 R:R:Y302 11.49 4 No Yes 6 7 2 2
L:L:K5 R:R:D122 4.15 4 Yes No 0 6 1 2
R:R:Q126 R:R:W269 3.29 4 Yes Yes 7 8 1 2
L:L:?4 R:R:Q126 7.46 4 Yes Yes 0 7 0 1
L:L:K5 R:R:Q126 5.42 4 Yes Yes 0 7 1 1
L:L:F3 R:R:I195 3.77 4 Yes Yes 0 5 1 2
R:R:F208 R:R:W204 11.02 4 Yes Yes 7 3 2 2
L:L:F3 R:R:W204 3.01 4 Yes Yes 0 3 1 2
L:L:F3 R:R:Y205 7.22 4 Yes Yes 0 4 1 2
L:L:F3 R:R:F208 5.36 4 Yes Yes 0 7 1 2
R:R:I209 R:R:N276 8.5 0 Yes No 5 6 2 1
R:R:F272 R:R:Y273 5.16 0 No No 6 7 1 2
L:L:?4 R:R:F272 6.83 4 Yes No 0 6 0 1
L:L:?4 R:R:N276 7.7 4 Yes No 0 6 0 1
R:R:F294 R:R:V298 6.55 0 Yes No 4 6 1 2
L:L:?4 R:R:F294 3.9 4 Yes Yes 0 4 0 1
L:L:C7 R:R:F294 2.79 19 Yes Yes 0 4 2 1
L:L:K5 R:R:Y302 3.58 4 Yes Yes 0 7 1 2
L:L:?4 L:L:F3 4.88 4 Yes Yes 0 0 0 1
L:L:?4 L:L:K5 23.71 4 Yes Yes 0 0 0 1
R:R:F275 R:R:F294 2.14 0 No Yes 4 4 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.08
Average Nodes In Shell20.00
Average Hubs In Shell14.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.78
Average Number Of Links With An Hub4.44
Average Interaction Strength8.83
Average Nodes In Shell20.67
Average Hubs In Shell11.67
Average Links In Shell29.22
Average Links Mediated by Hubs In Shell27.44

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)