Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.2185114
2A:A:L36 4.426117
3A:A:L37 7.352549
4A:A:L39 7.14449
5A:A:K46 6.775409
6A:A:M53 5.88408
7A:A:F192 5.44254115
8A:A:F197 6.667147117
9A:A:F200 8.31566
10A:A:E208 14.22754169
11A:A:R209 6.965449
12A:A:K211 11.5465169
13A:A:W212 7.445409
14A:A:I222 5.58333647
15A:A:F224 6.8125409
16A:A:D227 6.77754128
17A:A:Y231 6.5475408
18A:A:D250 7.6775449
19A:A:F251 6.222549
20A:A:I254 6.185448
21A:A:F259 5.864504
22A:A:F260 6.994549
23A:A:I265 3.5425446
24A:A:L267 4.0525409
25A:A:F268 5.4625219
26A:A:L269 4.2345128
27A:A:N270 4.3054219
28A:A:K271 7.4065129
29A:A:F275 7.135128
30A:A:C287 5.685404
31A:A:Y291 6.234506
32A:A:K311 6.73754244
33A:A:Y320 9.3875408
34A:A:M323 5.7575405
35A:A:T324 5.95754219
36A:A:C325 3.59754257
37A:A:N331 7.5854218
38A:A:F336 6.365118
39A:A:Y354 7.812505
40B:B:L7 3.3075408
41B:B:R22 3.812506
42B:B:I37 4.1825402
43B:B:V40 3.995473
44B:B:L51 8.6225409
45B:B:H54 7.683336139
46B:B:I58 5.04754139
47B:B:Y59 10.015468
48B:B:M61 4.34754176
49B:B:W63 7.183336177
50B:B:V71 4.88508
51B:B:D76 5.685409
52B:B:L79 4.3654107
53B:B:I80 7.394138
54B:B:W82 10.166139
55B:B:K89 5.66139
56B:B:H91 6.0445105
57B:B:I93 8.7554107
58B:B:L95 4.57754108
59B:B:W99 8.37143769
60B:B:Y105 4.66406
61B:B:Y111 5.1404
62B:B:C114 2.9354108
63B:B:E130 2.7425403
64B:B:H142 7.895639
65B:B:Y145 5.526508
66B:B:F151 5.46143739
67B:B:T159 4.90833639
68B:B:D163 9.165439
69B:B:C166 3.81458
70B:B:W169 9.86667638
71B:B:T173 4.3975435
72B:B:Q176 6.7725434
73B:B:F180 9.584557
74B:B:F199 6.978559
75B:B:V200 5.445426
76B:B:C204 5.3325167
77B:B:D205 8.098559
78B:B:K209 11.3025456
79B:B:L210 8.174525
80B:B:W211 9.562558
81B:B:Q220 8.8775427
82B:B:F222 9.205428
83B:B:H225 9.58167629
84B:B:D228 6.25254169
85B:B:I229 4.075427
86B:B:I232 3.63428
87B:B:F234 5.4675405
88B:B:F235 7.816676186
89B:B:P236 6.7254187
90B:B:N237 7.97754185
91B:B:F241 6.884526
92B:B:D247 5.206529
93B:B:D258 7.436527
94B:B:Q259 4.8825406
95B:B:T263 6.3675421
96B:B:Y264 6.262505
97B:B:H266 3.97404
98B:B:F278 10.35754187
99B:B:R283 7.20333679
100B:B:L285 7.2725406
101B:B:Y289 5.694297227
102B:B:D290 9.5875406
103B:B:V296 5.39405
104B:B:W297 7.8954228
105B:B:L300 4.3325476
106B:B:K301 2.8725405
107B:B:L308 5.7825407
108B:B:H311 9.4185159
109B:B:M325 5.224585
110B:B:W332 11.8617669
111B:B:D333 6.6454159
112B:B:L336 5.26754137
113B:B:K337 7.9325156
114B:B:W339 8.574159
115B:B:N340 7.0625489
116G:G:Y40 8.12754186
117G:G:D48 7.17833679
118G:G:L51 3.782576
119G:G:V54 4.9975486
120G:G:N59 5.49667689
121G:G:P60 6.3325489
122G:G:F61 5.26111988
123L:L:C2 6.4410
124L:L:F3 5.7610
125L:L:?4 8.3925810
126R:R:Y50 7.88833617
127R:R:I56 4.1054264
128R:R:V64 2.695409
129R:R:I68 3.998507
130R:R:Y71 7.5954276
131R:R:I77 5.2365194
132R:R:Y81 5.7285197
133R:R:L83 4.595406
134R:R:L85 4.8625499
135R:R:D89 6.342599
136R:R:F92 7.086516
137R:R:L96 7.5075417
138R:R:W108 9.793336148
139R:R:P109 7.075144
140R:R:F110 8.96254146
141R:R:I124 4.215405
142R:R:Q126 8.0875417
143R:R:F127 5.0875406
144R:R:M136 4.8325409
145R:R:R140 8.5425499
146R:R:Y141 8.315408
147R:R:V144 4.6025408
148R:R:R154 7.30754195
149R:R:R155 5.3275406
150R:R:I162 2.4454195
151R:R:L183 5.1285144
152R:R:N186 7.785411
153R:R:Q187 6.515412
154R:R:C193 5.9054149
155R:R:I195 6.094515
156R:R:N196 7.87413
157R:R:Y205 6.4725414
158R:R:F208 6.002517
159R:R:F217 4.9925418
160R:R:P220 4.505409
161R:R:Y228 6.026599
162R:R:W269 7.23714718
163R:R:Y273 6.62417
164R:R:F275 2.7575404
165R:R:F294 6.94414
166R:R:Y302 7.354517
167R:R:N304 6.7925409
168R:R:Y312 5.57333699
169R:R:F319 3.97508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I58 B:B:S316 35.07583.1YesNo099
2B:B:S316 B:B:W332 88.2656.18NoYes099
3B:B:R314 B:B:W332 46.259922.99NoYes089
4B:B:D290 B:B:R314 25.074721.44YesNo068
5B:B:D246 B:B:S227 19.23922.94NoNo096
6B:B:D247 B:B:S227 19.16782.94YesNo096
7B:B:D247 B:B:H225 15.3248.82YesYes299
8B:B:H225 B:B:T243 11.75486.85YesNo298
9B:B:I232 B:B:T243 11.71743.04YesNo288
10R:R:M136 R:R:Y312 14.1367.18YesYes099
11R:R:R140 R:R:Y312 75.644310.29YesYes999
12A:A:L353 R:R:R140 80.26639.72NoYes969
13A:A:L348 A:A:L353 80.64514.15NoNo086
14A:A:L348 R:R:V144 82.74162.98NoYes088
15R:R:V144 R:R:V235 83.26261.6YesNo088
16R:R:E251 R:R:V235 83.4369.98NoNo068
17R:R:E251 R:R:R247 83.782318.61NoNo064
18R:R:R247 R:R:V242 84.12815.23NoNo043
19A:A:E318 R:R:V242 84.242912.84NoNo043
20A:A:E318 A:A:Y320 84.931813.47NoYes048
21A:A:A338 A:A:Y320 85.84875.34NoYes078
22A:A:A338 A:A:I266 86.024.87NoNo078
23A:A:F268 A:A:I266 86.36225.02YesNo098
24A:A:F268 A:A:N270 91.16564.83YesYes2199
25A:A:C225 A:A:N270 97.45313.15NoYes079
26A:A:C225 A:A:G40 97.61741.96NoNo079
27A:A:F224 A:A:G40 98.92664.52YesNo099
28A:A:D250 A:A:F224 60.92218.36YesYes099
29A:A:D250 A:A:I254 46.25248.4YesYes498
30A:A:I222 A:A:I254 45.5832.94YesYes478
31A:A:F260 A:A:I222 99.4668.79YesYes497
32A:A:F260 A:A:I213 99.984411.3YesNo098
33A:A:F259 A:A:I213 1006.28YesNo048
34A:A:F259 A:A:H214 40.54444.53YesNo048
35A:A:H214 B:B:W332 41.19815.29NoYes089
36A:A:F224 A:A:F251 46.234510.72YesYes099
37A:A:F251 A:A:I265 54.93155.02YesYes496
38A:A:I222 A:A:I265 55.53392.94YesYes476
39A:A:F259 B:B:R314 59.65936.41YesNo048
40A:A:M53 A:A:N331 10.69047.01YesYes088
41A:A:S207 B:B:Y145 14.55056.36NoYes088
42A:A:S207 A:A:W212 14.48886.18NoYes089
43A:A:R209 A:A:W212 14.12346YesYes099
44A:A:F251 A:A:F308 10.29283.22YesNo098
45A:A:L267 A:A:L269 15.67974.15YesYes098
46A:A:F224 A:A:L267 13.16013.65YesYes099
47A:A:K211 B:B:Y145 14.91445.97YesYes098
48B:B:D228 B:B:D246 14.42766.65YesNo099
49B:B:M325 G:G:P60 22.49263.35YesYes859
50B:B:M325 G:G:P49 65.57558.39YesNo057
51G:G:D48 G:G:P49 63.77264.83YesNo097
52G:G:D48 G:G:L51 51.76174.07YesYes796
53B:B:R283 G:G:L51 45.20957.29YesYes796
54B:B:I37 B:B:R283 16.64325.01YesYes029
55B:B:L30 B:B:T34 10.04552.95NoNo055
56B:B:L300 B:B:R283 10.04443.64YesYes769
57B:B:N340 G:G:F61 23.04223.62YesYes898
58G:G:F61 G:G:N59 25.49534.83YesYes889
59B:B:L336 B:B:L51 26.15374.15YesYes079
60B:B:I338 B:B:L51 25.86224.28NoYes059
61B:B:M61 B:B:W63 52.27545.82YesYes1767
62B:B:C317 B:B:S316 53.02073.44NoNo079
63B:B:C317 B:B:M61 52.83444.86NoYes076
64B:B:S84 B:B:W63 25.62834.94NoYes057
65B:B:S84 G:G:F61 25.43515.28NoYes058
66B:B:C271 B:B:D290 20.44697.78NoYes056
67B:B:C271 B:B:D291 20.32054.67NoNo058
68B:B:D291 B:B:Y289 20.00124.6NoYes087
69B:B:L285 B:B:Y264 11.93254.69YesYes065
70B:B:F278 B:B:L285 17.283118.27YesYes076
71B:B:C233 B:B:F278 12.18735.59NoYes037
72B:B:C233 B:B:S277 11.88643.44NoNo035
73R:R:L85 R:R:Y312 35.61213.52YesYes999
74R:R:D89 R:R:L85 35.11275.43YesYes999
75R:R:D89 R:R:S305 33.2978.83YesNo098
76R:R:F92 R:R:S305 33.09497.93YesNo068
77R:R:F92 R:R:Q126 21.33835.86YesYes167
78L:L:?4 R:R:Q126 40.85637.4YesYes107
79L:L:?4 R:R:F294 21.00245.8YesYes104
80L:L:C2 R:R:F294 17.097312.57YesYes104
81L:L:?1 L:L:C2 13.1564.03NoYes100
82R:R:L133 R:R:Y312 27.03824.69NoYes999
83R:R:L133 R:R:N308 26.8538.24NoNo099
84R:R:N304 R:R:N308 26.655112.26YesNo099
85R:R:N304 R:R:W269 26.06055.65YesYes098
86R:R:Q126 R:R:W269 20.621410.95YesYes178
87L:L:?1 L:L:T8 12.73356.25NoNo100
88L:L:?4 R:R:T212 10.97273.51YesNo004
89L:L:T8 R:R:N186 10.53985.85NoYes101
90R:R:F92 R:R:Y302 11.42017.22YesYes167
91R:R:F127 R:R:T212 10.11982.59YesNo064
92A:A:D250 A:A:R209 14.80299.53YesYes499
93A:A:K211 B:B:D228 14.06288.3YesYes1699
94B:B:I58 B:B:L336 26.52124.28YesYes1397
95B:B:I338 G:G:F61 51.08433.77NoYes058
96B:B:I338 B:B:W63 25.62924.7NoYes057
97G:G:F61 G:G:P60 23.04174.33YesYes889
98B:B:M325 B:B:N340 22.44265.61YesYes859
99B:B:M325 G:G:N59 22.44234.21YesYes859
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C2 R:R:F294 12.57 1 Yes Yes 0 4 0 1
L:L:F3 R:R:I195 3.77 1 Yes Yes 0 5 0 1
L:L:F3 R:R:N196 7.25 1 Yes Yes 0 3 0 1
L:L:F3 R:R:Y205 7.22 1 Yes Yes 0 4 0 1
L:L:F3 R:R:I209 7.54 1 Yes No 0 5 0 1
L:L:?4 R:R:Q126 7.4 1 Yes Yes 0 7 0 1
L:L:?4 R:R:I195 5.66 1 Yes Yes 0 5 0 1
L:L:?4 R:R:T212 3.51 1 Yes No 0 4 0 1
L:L:?4 R:R:F272 6.77 1 Yes No 0 6 0 1
L:L:?4 R:R:N276 9.81 1 Yes No 0 6 0 1
L:L:?4 R:R:F294 5.8 1 Yes Yes 0 4 0 1
L:L:K5 R:R:D122 8.3 1 No No 0 6 0 1
L:L:K5 R:R:Q126 8.14 1 No Yes 0 7 0 1
L:L:T6 R:R:S192 3.2 0 No No 0 4 0 1
L:L:C7 R:R:K291 3.23 1 No No 0 3 0 1
L:L:T8 R:R:N186 5.85 1 No Yes 0 1 0 1
L:L:T8 R:R:Q187 4.25 1 No Yes 0 2 0 1
R:R:D122 R:R:F92 7.17 1 No Yes 6 6 1 2
R:R:F92 R:R:Q126 5.86 1 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 7.22 1 Yes Yes 6 7 2 2
R:R:Q102 R:R:S192 7.22 14 No No 5 4 2 1
R:R:N186 R:R:V106 7.39 1 Yes No 1 4 1 2
R:R:V106 R:R:W188 12.26 1 No No 4 2 2 2
R:R:D122 R:R:Y302 5.75 1 No Yes 6 7 1 2
R:R:Q126 R:R:W269 10.95 1 Yes Yes 7 8 1 2
R:R:I177 R:R:I195 7.36 1 No Yes 3 5 2 1
R:R:F208 R:R:I177 5.02 1 Yes No 7 3 2 2
R:R:R184 R:R:Y205 8.23 1 No Yes 2 4 2 1
R:R:N186 R:R:Q187 6.6 1 Yes Yes 1 2 1 1
R:R:N186 R:R:W188 11.3 1 Yes No 1 2 1 2
R:R:Q187 R:R:W188 12.05 1 Yes No 2 2 1 2
R:R:P286 R:R:Q187 3.16 0 No Yes 2 2 2 1
R:R:I195 R:R:N196 9.91 1 Yes Yes 5 3 1 1
R:R:F208 R:R:I195 3.77 1 Yes Yes 7 5 2 1
R:R:N196 R:R:Y205 4.65 1 Yes Yes 3 4 1 1
R:R:F208 R:R:N196 9.67 1 Yes Yes 7 3 2 1
R:R:G202 R:R:Y205 5.79 0 No Yes 2 4 2 1
R:R:T206 R:R:V280 4.76 0 No No 3 4 2 1
R:R:F208 R:R:I209 3.77 1 Yes No 7 5 2 1
R:R:F208 R:R:T212 7.78 1 Yes No 7 4 2 1
R:R:I209 R:R:N276 5.66 0 No No 5 6 1 1
R:R:W269 R:R:Y273 4.82 1 Yes Yes 8 7 2 2
R:R:F272 R:R:Y273 7.22 0 No Yes 6 7 1 2
R:R:F272 R:R:V297 3.93 0 No No 6 7 1 2
R:R:F294 R:R:N276 7.25 1 Yes No 4 6 1 1
R:R:K291 R:R:N43 2.8 0 No No 3 3 1 2
L:L:F3 R:R:V280 2.62 1 Yes No 0 4 0 1
R:R:F127 R:R:T212 2.59 0 Yes No 6 4 2 1
R:R:F275 R:R:F294 2.14 0 Yes Yes 4 4 2 1
R:R:G292 R:R:K291 1.74 0 No No 1 3 2 1
L:L:C2 R:R:S279 1.72 1 Yes No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
68.75Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
66.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
62.50Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
61.11Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
57.89Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
55.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
53.33Single7AROLUF58337ARO-A2A-LUF5833-Na
53.33Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
53.33Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
52.94Single6J21Aprepitant6J21-NK1-Aprepitant
52.94Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
52.63Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
52.63Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
52.63Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
52.63Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
52.38Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
52.38Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
52.38Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
50.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
50.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
50.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
50.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
50.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
50.00Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
50.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensusa3_onOrthosteric Liganda3a_on
50.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
50.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
48.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
48.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
48.00Consensusbradykinin_onOrthosteric Ligandbk2_on
48.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
48.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
47.83Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
47.83Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
47.62Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
47.62Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
47.62Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
47.37Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.37Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.37Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.37Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
47.06Single5N2SPSB365N2S-A1-PSB36
47.06Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.06Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
47.06Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
47.06Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
47.06Single8QOTNanobody-E8QOT-μ-Nanobody-E
47.06Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
47.06Consensusa3_on_gpOrthosteric Liganda3a_on_gp
47.06Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.06Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
46.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
46.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
46.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
46.67Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
46.67Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
46.67Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
46.67Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
46.15Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
46.15Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
46.15Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
45.83Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
45.83Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
45.45Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
45.45Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
45.45Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
45.45Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
45.00Single3NY9ICI118-5513NY9-β2-ICI118-551
45.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single7XN9L-054,5227XN9-SST2-L-054,522
45.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
45.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
44.44Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
44.44Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
44.44Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
44.44Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
44.44Consensusa2_onOrthosteric Liganda2b_on
44.44Consensusa2_on_gpOrthosteric Liganda2b_on_gp
44.44Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
44.44Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
44.44Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
44.44Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
44.44Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
44.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
43.75Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
43.75Single5UVIZM-2413855UVI-A2A-ZM-241385
43.75Single6MH8ZM-2413856MH8-A2A-ZM-241385
43.75Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
43.75Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
43.75Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
43.75Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
43.75Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
43.75Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
43.75Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
43.48Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
43.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
43.48Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
42.86Single4IARErgotamine4IAR-5-HT1B-Ergotamine
42.86Single8WDTphotoNECA8WDT-A2A-photoNECA
42.86Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
42.86Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
42.86Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
42.86Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
42.86Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
42.86Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
42.11Single4RWADIPP-NH24RWA-δ-DIPP-NH2
42.11Single6MXTSalmeterol6MXT-β2-Salmeterol
42.11Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
42.11Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
42.11Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
42.11Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
42.11Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
41.67Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
41.67Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.38Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
41.18Single3EMLZM-2413853EML-A2A-ZM-241385
41.18Single4EJ4Naltrindole4EJ4-δ-Naltrindole
41.18Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
41.18Single5UENDU1725UEN-A1-DU172
41.18Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
41.18Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
41.18Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
41.18Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
41.18Single6S0LZM-2413856S0L-A2A-ZM-241385
41.18Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
41.18Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
41.18Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
41.18Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
41.18Single8CU6LJ-45178CU6-A2A-LJ-4517
41.18Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
41.18Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
41.18Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
41.18Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
41.18Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
41.18Single9CHXS-Carazolol9CHX-β2-S-Carazolol
41.18Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
41.18Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
41.18Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
41.18Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
41.18Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
40.91Single3QAKUK-4320973QAK-A2A-UK-432097
40.91Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
40.91Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
40.91Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
40.91Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
40.91Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
40.91Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
40.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
40.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
40.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
40.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
40.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
40.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
40.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
40.00Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
40.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
40.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
40.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
40.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
40.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
40.00Consensuschemerin_onOrthosteric Ligandcml1_on
40.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
40.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
40.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
39.13Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
39.13Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
39.13Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Consensusangiotensin_onOrthosteric Ligandat1_on
39.13Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
39.13Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
38.89Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
38.89Single5IUAQ274563485IUA-A2A-Q27456348-Na
38.89Single5N2RPSB-365N2R-A2A-PSB-36-Na
38.89Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
38.89Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
38.89Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
38.89Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
38.89Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
38.89Single6S0QZM-2413856S0Q-A2A-ZM-241385
38.89Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
38.89Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
38.89Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
38.89Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
38.89Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
38.89Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single8GNEKW-63568GNE-A2A-KW-6356-Na
38.89Single8TF5Oleic acid8TF5-GPR6-Oleic acid
38.89Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
38.89Consensusadenosine_offOrthosteric Liganda1_off a2_off
38.89Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
38.89Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
38.46Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.46Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.46Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
38.46Single9KDFRES-701-39KDF-ETB-RES-701-3
38.46Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
38.46Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.46Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.46Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
38.46Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
38.10Single4UG2CGS216804UG2-A2A-CGS21680
38.10Single5WF6UK-4320975WF6-A2A-UK-432097
38.10Single6PT3DPI-2876PT3-δ-DPI-287
38.10Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
38.10Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
38.10Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
38.10Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
38.10Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
38.10Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
38.10Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.10Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
37.93Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
37.50Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
37.50Single3PWHZM-2413853PWH-A2A-ZM-241385
37.50Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
37.50Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
37.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
37.50Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
37.50Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
37.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
37.50Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
37.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
37.50Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
37.50Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
37.50Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
37.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
37.50Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
37.50Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
37.50Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.50Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
37.50Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
37.50Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
37.50Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
37.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
37.50Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
37.50Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
37.50Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.50Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
37.50Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
37.04Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.84Single2YDVNECA2YDV-A2A-NECA
36.84Single3P0GBI1671073P0G-β2-BI167107
36.84Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
36.84Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.84Single4UHRCGS216804UHR-A2A-CGS21680
36.84Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
36.84Single5G53NECA5G53-A2A-NECA-Gs
36.84Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
36.84Single6J20Aprepitant6J20-NK1-Aprepitant
36.84Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
36.84Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
36.84Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
36.84Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.84Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
36.84Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.84Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
36.84Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
36.84Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
36.84Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Single9BJKNaloxone9BJK-μ-Naloxone-NAM
36.84Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
36.84Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
36.84Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
36.84Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.84Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
36.84Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
36.84Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
36.84Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
36.84Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
36.84Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
36.84Consensustachykinin_offOrthosteric Ligandnk1_off
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
36.36Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
36.36Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
36.36Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
36.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
36.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
36.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
36.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
36.00Single8ZRTET-18ZRT-ETB-ET-1
36.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
36.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
35.71Single3RFMCaffeine3RFM-A2A-Caffeine
35.71Single8A2OTheophylline8A2O-A2A-Theophylline-Na
35.29Single2YDOAdenosine2YDO-A2A-Adenosine
35.29Single3REYXAC3REY-A2A-XAC
35.29Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
35.29Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
35.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
35.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5JTBZM-2413855JTB-A2A-ZM-241385
35.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
35.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
35.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
35.29Single6AQFZM-2413856AQF-A2A-ZM-241385
35.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
35.29Single6PS0S-Carazolol6PS0-β2-S-Carazolol
35.29Single6PS4ICI118-5516PS4-β2-ICI118-551
35.29Single6PS5S-Propranolol6PS5-β2-S-Propranolol
35.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
35.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
35.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
35.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
35.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
35.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
35.29Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
35.29Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
35.29Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
35.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
35.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
35.29Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
35.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
35.29Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single9ARXSerotonin9ARX-5-HT2A-Serotonin
35.29Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
35.29Consensusa2_offOrthosteric Liganda2a_off
35.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
35.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
35.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
35.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
35.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
35.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
35.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
35.00Single7YITNalfurafine7YIT-κ-Nalfurafine
35.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
35.00Single8JJ8Formoterol8JJ8-β2-Formoterol
35.00Single8JJLOlodaterol8JJL-β2-Olodaterol
35.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
35.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
35.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
35.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
35.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
35.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
35.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
35.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
35.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
35.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
35.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
34.78Single6HLOAprepitant6HLO-NK1-Aprepitant
34.78Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
34.78Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
34.78Single8IEBA1LYA8IEB-GPR156-A1LYA
34.78Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
34.78Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
34.78Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.78Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.78Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
34.78Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
34.78Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.62Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
34.62Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
34.62Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
33.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
33.33Single3NY8ICI118-5513NY8-β2-ICI118-551
33.33Single3OE0CVX153OE0-CXCR4-CVX15
33.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
33.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
33.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
33.33Single4GBRS-Carazolol4GBR-β2-S-Carazolol
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
33.33Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
33.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
33.33Single6IBLArformoterol6IBL-β1-Arformoterol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
33.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
33.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
33.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
33.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
33.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
33.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
33.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
33.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
33.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
33.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
33.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
33.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
33.33Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
33.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
33.33Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
33.33Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
33.33Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
33.33Single9H37A1IR09H37-A2A-A1IR0-Na
33.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
33.33Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
33.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
33.33Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
33.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
33.33Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
33.33Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
33.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusdopamine_offOrthosteric Ligandd2_off d3_off
33.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
33.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
33.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
32.14Single8IY6Endothelin-18IY6-ETB-Endothelin-1
32.14Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
32.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
32.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
32.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
32.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
32.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
32.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
32.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
32.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
32.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
32.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
32.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
31.82Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.82Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
31.82Single8QJ2pN1628QJ2-MC4-pN162-Gs
31.82Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
31.82Single8XQJJN2418XQJ-Apelin-JN241
31.82Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
31.82Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
31.82Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
31.82Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
31.82Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.82Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single2RH1S-Carazolol2RH1-β2-S-Carazolol
31.58Single2YCWS-Carazolol2YCW-β1-S-Carazolol
31.58Single4NTJAZD12834NTJ-P2Y12-AZD1283
31.58Single5C1MBU725C1M-μ-BU72
31.58Single5D6LS-Carazolol5D6L-β2-S-Carazolol
31.58Single5JQHS-Carazolol5JQH-β2-S-Carazolol
31.58Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
31.58Single5TVNLSD5TVN-5-HT2B-LSD
31.58Single6E67BI1671076E67-β2-BI167107-Gs(CT)
31.58Single6HLPNetupitant6HLP-NK1-Netupitant
31.58Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
31.58Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
31.58Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
31.58Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
31.58Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.58Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
31.58Single7C61Ergotamine7C61-5-HT1B-Ergotamine
31.58Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
31.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.58Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.58Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
31.58Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
31.58Single7W41PD1762527W41-BB2-PD176252
31.58Single7WC6LSD7WC6-5-HT2A-LSD
31.58Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
31.58Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
31.58Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
31.58Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8JXSPF-61428JXS-D1-PF-6142
31.58Single8S4DCMF-0198S4D-Apelin-CMF-019
31.58Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
31.58Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
31.58Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
31.58Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
31.58Single9EHSLUF76029EHS-A3A-LUF7602
31.58Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
31.58Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
31.58Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
31.58Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
31.58Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
31.58Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
31.58Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
31.58Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
31.58Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
31.58Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.58Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
31.58Consensusamine_offonOrthosteric Ligandamine_off amine_on
31.58Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
31.58Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
31.58Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.58Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
31.58Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
31.58Consensusbombesin_offOrthosteric Ligandbb2_off
31.58Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
31.58Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.58Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
31.58Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Consensustrace-amine_onOrthosteric Ligandta1_on
31.25Single3PBLEticlopride3PBL-D3-Eticlopride
31.25Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
31.25Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
31.25Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
31.25Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
31.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
31.25Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
31.25Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
31.25Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.25Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.25Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
31.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
30.77Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
30.77Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
30.77Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
30.77Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.77Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.77Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
30.43Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
30.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
30.43Single7F8XNN90567F8X-CCKA-NN9056
30.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
30.43Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
30.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
30.43Single8IEBA1LYA8IEB-GPR156-A1LYA
30.43Single8IEIA1LYA8IEI-GPR156-A1LYA
30.43Single8IEPA1LYA8IEP-GPR156-A1LYA
30.43Single8IEPA1LYA8IEP-GPR156-A1LYA
30.43Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
30.43Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.43Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
30.43Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
30.43Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
30.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
30.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
30.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
30.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
30.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
30.00Single6E59L-7607356E59-NK1-L-760735
30.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
30.00Single6WGTLSD6WGT-5-HT2A-LSD
30.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
30.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
30.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
30.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
30.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
30.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
30.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
30.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
30.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
30.00Single8E0GBU728E0G-μ-BU72
30.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
30.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
30.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
30.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
30.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
30.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
30.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
30.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
30.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
30.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
30.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
30.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
30.00Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
30.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
30.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
30.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
30.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
30.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
30.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
30.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
30.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
30.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
30.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
30.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
29.63Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
29.63Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.63Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.41Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single6AKXA4R6AKX-CCR5-A4R
29.41Single6AKYMaraviroc6AKY-CCR5-Maraviroc
29.41Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
29.41Single6ME2Ramelteon6ME2-MT1-Ramelteon
29.41Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
29.41Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
29.41Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.41Single6TODEMPA6TOD-OX1-EMPA-Na
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single7BR3Elagolix7BR3-GnRH1-Elagolix
29.41Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
29.41Single7F8ULintitript7F8U-CCKA-Lintitript
29.41Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
29.41Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
29.41Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
29.41Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
29.41Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
29.41Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
29.41Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
29.41Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
29.41Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
29.41Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
29.41Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
29.41Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
29.41Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
29.41Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
29.41Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
29.41Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
29.41Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
29.41Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
29.41Single9H2XA1IR19H2X-A2A-A1IR1-Na
29.41Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
29.41Consensusalpha2_offOrthosteric Ligandalpha2c_off
29.41Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
29.41Consensusorexin_offOrthosteric Ligandox2_off ox1_off
29.41Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
29.41Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.17Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
29.17Single7XNACYN1548067XNA-SST2-CYN154806
29.17Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
29.17Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
29.17Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
29.17Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
29.17Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
29.17Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
29.17Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.17Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
29.17Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3D4STimolol3D4S-β2-Timolol
28.57Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
28.57Single4AMIBucindolol4AMI-β1-Bucindolol
28.57Single4LDEBI1671074LDE-β2-BI167107
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
28.57Single4XEENeurotensin4XEE-NTS1-Neurotensin
28.57Single4XESNeurotensin4XES-NTS1-Neurotensin
28.57Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
28.57Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
28.57Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
28.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
28.57Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
28.57Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
28.57Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.57Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
28.57Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
28.57Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
28.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
28.57Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
28.57Single8JWY2-1188JWY-A2A-2-118
28.57Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
28.57Single8PWNTheophylline8PWN-A2A-Theophylline
28.57Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
28.57Single8XQJJN2418XQJ-Apelin-JN241
28.57Single8XWACXCL18XWA-CXCR2-CXCL1
28.57Single8XWMCXCL68XWM-CXCR2-CXCL6
28.57Single8XWSCXCL58XWS-CXCR2-CXCL5
28.57Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
28.57Single8XYIVUF106618XYI-CXCR3-VUF10661
28.57Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
28.57Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
28.57Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
28.57Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
28.57Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.57Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.57Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
28.57Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.57Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusorexin_onOrthosteric Ligandox2_on
28.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
28.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
28.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
28.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
28.00Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
28.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
28.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
28.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.78Single4ZJCSB-6740424ZJC-OX1-SB-674042
27.78Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
27.78Single6A94Zotepine6A94-5-HT2A-Zotepine
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
27.78Single6TPGEMPA6TPG-OX2-EMPA
27.78Single6TPKRetosiban6TPK-OT-Retosiban
27.78Single6TPNHTL66416TPN-OX2-HTL6641
27.78Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
27.78Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
27.78Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
27.78Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
27.78Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
27.78Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
27.78Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
27.78Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
27.78Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.78Single7UL3Famotidine7UL3-H2-Famotidine
27.78Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
27.78Single7VV6C48/807VV6-MRGPRX2-C48/80
27.78Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
27.78Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
27.78Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
27.78Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
27.78Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
27.78Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
27.78Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
27.78Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
27.78Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
27.78Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
27.78Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
27.78Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
27.78Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.78Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
27.78Single8ZPNAMD31008ZPN-CXCR4-AMD3100
27.78Single9AS3LSD9AS3-5-HT2A-LSD
27.78Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9AS5Mescaline9AS5-5-HT2A-Mescaline
27.78Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
27.78Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
27.78Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
27.78Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
27.78Consensusalpha1_onOrthosteric Ligandalpha1a_on
27.78Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
27.78Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
27.78Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
27.78Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.78Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.78Consensusgrh_offOrthosteric Ligandgnrh1_off
27.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.78Consensusvasop-oxy_offOrthosteric Ligandot_off
27.59Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
27.59Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.59Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
27.27Single4BUONeurotensin4BUO-NTS1-Neurotensin
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
27.27Single6H7LDobutamine6H7L-β1-Dobutamine
27.27Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
27.27Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
27.27Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
27.27Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
27.27Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
27.27Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
27.27Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
27.27Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
27.27Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
27.27Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
27.27Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
27.27Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
27.27Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
27.27Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
27.27Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
27.27Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single8XVUCXCL28XVU-CXCR2-CXCL2
27.27Single8XWFCXCL38XWF-CXCR2-CXCL3
27.27Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
27.27Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
27.27Single8ZPLHF511168ZPL-CXCR4-HF51116
27.27Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
27.27Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
27.27Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.27Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.27Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
27.27Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
27.27Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
27.27Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
26.92Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.92Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
26.92Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
26.67Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
26.67Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
26.67Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
26.67Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
26.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.67Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
26.67Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
26.67Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
26.67Consensusp2y_offOrthosteric Ligandp2y1_off
26.67Consensussensory_onOrthosteric Ligandopsins_on
26.32Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single2Y04Salbutamol2Y04-β1-Salbutamol
26.32Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
26.32Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
26.32Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Single4QKX35V4QKX-β2-35V
26.32Single5UIGCmpd-15UIG-A2A-Cmpd-1
26.32Single6D27CAY104716D27-DP2-CAY10471
26.32Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
26.32Single6H7MSalbutamol6H7M-β1-Salbutamol
26.32Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
26.32Single6TOTLemborexant6TOT-OX1-Lemborexant
26.32Single7BU7BI1671077BU7-β1-BI167107
26.32Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
26.32Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.32Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
26.32Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
26.32Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
26.32Single7WC7Lisuride7WC7-5-HT2A-Lisuride
26.32Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
26.32Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
26.32Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.32Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
26.32Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
26.32Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.32Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
26.32Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
26.32Single8JJOAlprenolol8JJO-β2-Alprenolol
26.32Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.32Single8JXRLSD8JXR-D1-LSD
26.32Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
26.32Single8T1WCVN4248T1W-GPR6-CVN424
26.32Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.32Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
26.32Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
26.32Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.32Single8X64Desloratadine8X64-H1-Desloratadine
26.32Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
26.32Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
26.32Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.32Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.32Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
26.32Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.32Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
26.32Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
26.32Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
26.32Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
26.32Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.32Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.32Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
26.32Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.09Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
26.09Single5ZTYAM102575ZTY-CB2-AM10257
26.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.09Single6KNMJN241-96KNM-Apelin-JN241-9
26.09Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.09Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
26.09Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
26.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
26.09Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
26.09Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
26.09Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
26.09Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
26.09Single9IPYJR14a9IPY-C3aB-JR14a
26.09Single9JF4PD1683689JF4-BB1-PD168368
26.09Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.09Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
26.09Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskisspeptin_onOrthosteric Ligandkiss1_on
26.09Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
26.09Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
25.93Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
25.93Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.93Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
25.93Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.93Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.81Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.81Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
25.00Single3UZAGTPL92363UZA-A2A-GTPL9236
25.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.00Single5WIUNemonapride5WIU-D4-Nemonapride
25.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
25.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single5WQCEMPA5WQC-OX2-EMPA
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
25.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
25.00Single6Z4SSR486926Z4S-NTS1-SR48692
25.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
25.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
25.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
25.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
25.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
25.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
25.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Single8IEIA1LYA8IEI-GPR156-A1LYA
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
25.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
25.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
25.00Single8WKYPG-9348WKY-MC4-PG-934
25.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
25.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.00Single8XWNCXCL88XWN-CXCR2-CXCL8
25.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
25.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
25.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
25.00Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
25.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
25.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
25.00Single9HAPTolvaptan9HAP-V2-Tolvaptan
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
25.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
25.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
25.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
25.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
25.00Consensusdp_offOrthosteric Liganddp2_off
25.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
25.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
25.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
25.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
25.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
25.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
25.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
25.00Consensussomatostatin_offOrthosteric Ligandsst2_off
24.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
24.14Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
24.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
24.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
24.00Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
24.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
24.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
24.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
23.81Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.81Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.81Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.81Single5XR8AM8415XR8-CB1-AM841
23.81Single5XRAAM115425XRA-CB1-AM11542
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
23.81Single7B6WCyclazosin7B6W-α1b-Cyclazosin
23.81Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
23.81Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.81Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
23.81Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
23.81Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
23.81Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
23.81Single7R0CAVP7R0C-V2-AVP-Arrestin2
23.81Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.81Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
23.81Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
23.81Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.81Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
23.81Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
23.81Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
23.81Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
23.81Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.81Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
23.81Single8ZWFJR14a8ZWF-C3aB-JR14a
23.81Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
23.81Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
23.81Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
23.81Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
23.81Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensuslpa_onOrthosteric Ligandlpa1_on
23.81Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
23.81Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusneurotensin_onOrthosteric Ligandnts1_on
23.81Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.81Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.81Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.81Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.53Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7SRQLSD7SRQ-5-HT2B-LSD
23.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
23.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.53Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
23.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
23.53Single8K5BNiacin8K5B-HCA2-Niacin
23.53Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
23.53Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.53Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
23.53Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
23.08Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
23.08Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
23.08Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
23.08Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.86Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.86Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.73Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
22.73Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
22.73Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
22.73Single6OS2TRV0266OS2-AT1-TRV026
22.73Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
22.73Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
22.73Single6YVRNTS8-136YVR-NTS1-NTS8-13
22.73Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
22.73Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
22.73Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
22.73Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
22.73Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.73Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
22.73Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
22.73Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
22.73Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
22.73Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
22.73Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single9DGIZ85267113509DGI-CB1-Z8526711350
22.73Consensusalpha1_offOrthosteric Ligandalpha1a_off
22.73Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
22.73Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
22.73Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
22.73Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
22.73Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.73Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
22.73Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
22.73Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
22.73Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.73Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.73Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.73Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
22.73Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
22.73Consensuslpl_offOrthosteric Ligands1p_off lpa_off
22.73Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
22.73Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
22.73Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
22.73Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
22.73Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
22.73Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.73Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.73Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
22.73Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
22.58Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbombesin_onOrthosteric Ligandbb2_on
22.58Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
22.58Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
22.22Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.22Single5WS3EMPA5WS3-OX2-EMPA
22.22Single6B73MP11046B73-κ-MP1104
22.22Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.22Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
22.22Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.22Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
22.22Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
22.22Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
22.22Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
22.22Single7XRRLemborexant7XRR-OX2-Lemborexant
22.22Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
22.22Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
22.22Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
22.22Single8IWESpermidine8IWE-TA9-Spermidine
22.22Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
22.22Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
22.22Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
22.22Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
22.22Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
22.22Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
22.22Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
22.22Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
22.22Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
22.22Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
22.22Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
21.74Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.74Single5X93K-87945X93-ETB-K-8794
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.74Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
21.74Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
21.74Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
21.74Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
21.74Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.74Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
21.74Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
21.74Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.74Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
21.74Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
21.74Consensusendothelin_offOrthosteric Ligandetb_off
21.74Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
21.74Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensusprostanoid_offOrthosteric Ligandep_off dp_off
21.43Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.43Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.43Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
21.43Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.43Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
21.43Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
21.43Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
21.43Consensuspac_onOrthosteric Ligandpac1_on
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single3RZECidoxepin3RZE-H1-Cidoxepin
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
21.05Single6KUXRS-799486KUX-α2a-RS-79948
21.05Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.05Single6V9SGTPL114036V9S-OX1-GTPL11403
21.05Single6VI4JDTic6VI4-κ-JDTic
21.05Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
21.05Single6ZINSR486926ZIN-NTS1-SR48692
21.05Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
21.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
21.05Single7F61PF-036547467F61-H3-PF-03654746
21.05Single7T32ZM-2413857T32-A2A-ZM-241385
21.05Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
21.05Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
21.05Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
21.05Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
21.05Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.05Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.05Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
21.05Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
21.05Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
21.05Single8K5CAcipimox8K5C-HCA2-Acipimox
21.05Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
21.05Single8RLNLUF58348RLN-A2A-LUF5834
21.05Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
21.05Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
21.05Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
21.05Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
21.05Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
21.05Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
21.05Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
21.05Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
21.05Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
21.05Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Consensushca_onOrthosteric Ligandhca2_on
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.83Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.83Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
20.83Single8X5YAstemizole8X5Y-H1-Astemizole
20.83Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
20.83Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
20.83Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
20.69Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.69Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.69Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.69Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
20.59Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
20.00Single2Y01Dobutamine2Y01-β1-Dobutamine
20.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
20.00Single4QIMANTA XV4QIM-SMO-ANTA XV
20.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
20.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7V3ZCP559407V3Z-CB1-CP55940
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
20.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
20.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
20.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
20.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
20.00Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
20.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.00Single9AS1DMT9AS1-5-HT2A-DMT
20.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
20.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
20.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
20.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
20.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
20.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
20.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.00Consensushistamine_offOrthosteric Ligandh1_off
19.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.35Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.23Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
19.23Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.23Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
19.05Single2Y00Dobutamine2Y00-β1-Dobutamine
19.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
19.05Single5XPRBosentan5XPR-ETB-Bosentan
19.05Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
19.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
19.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
19.05Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
19.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
19.05Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
19.05Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
19.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.05Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
19.05Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
19.05Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
19.05Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
19.05Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
19.05Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.05Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.75Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.75Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
18.75Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.75Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
18.75Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
18.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.52Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
18.52Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.52Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
18.52Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
18.52Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
18.18Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.18Single4DJHJDTic4DJH-κ-JDTic
18.18Single4U15Tiotropium4U15-M3-Tiotropium
18.18Single5TZRMK86665TZR-FFA1-MK8666
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
18.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6OL9Tiotropium6OL9-M5-Tiotropium
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single6TQ7SB-3348676TQ7-OX1-SB-334867
18.18Single7F1TMIP-1a7F1T-CCR5-MIP-1a
18.18Single7FEECP559407FEE-CB1-CP55940-ZCZ011
18.18Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
18.18Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
18.18Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
18.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
18.18Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
18.18Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.18Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
18.18Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
18.18Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.18Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
18.18Single8XVLZibotentan8XVL-ETA-Zibotentan
18.18Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.18Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
18.18Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.18Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
18.18Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
18.18Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
18.18Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.18Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.86Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
17.86Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.86Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.86Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.86Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.65Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.65Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
17.65Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
17.65Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.65Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.65Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.65Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.65Single9LRCHistamine9LRC-H4-Histamine
17.65Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
17.65Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.65Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.65Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.65Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single5CXVTiotropium5CXV-M1-Tiotropium
17.39Single6A93Risperidone6A93-5-HT2A-Risperidone
17.39Single6CM4Risperidone6CM4-D2-Risperidone
17.39Single6KQICP559406KQI-CB1-CP55940-Org27569
17.39Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.39Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.39Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
17.39Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.39Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.39Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
17.39Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
17.39Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
17.39Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
17.39Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
17.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
17.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
17.14Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single4XT3Fractalkine4XT3-US28-Fractalkine
16.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.67Single6FJ3PTH6FJ3-PTH1-PTH
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.67Single7SK3CXCL127SK3-ACKR3-CXCL12
16.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
16.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7UL2SR486927UL2-NTS1-SR48692-Na
16.67Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
16.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
16.67Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
16.67Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
16.67Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AS7Psilocin9AS7-5-HT2A-Psilocin
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
16.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
16.67Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
16.67Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensusneurotensin_offOrthosteric Ligandnts1_off
16.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.67Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.13Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.13Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.13Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.13Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.13Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.13Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
16.13Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.00Single7SK9CCX6627SK9-ACKR3-CCX662
16.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
15.79Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.79Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.79Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.79Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.79Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6DS0Ly2660976DS0-5-HT2B-Ly266097
15.79Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
15.79Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
15.79Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
15.79Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
15.79Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.79Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.79Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
15.79Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
15.79Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
15.79Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
15.79Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.79Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
15.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.79Single8Y0HVUF114188Y0H-CXCR3-VUF11418
15.79Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
15.79Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
15.79Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
15.79Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
15.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.79Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.79Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.79Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.79Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.79Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
15.79Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
15.79Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.79Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
15.62Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
15.62Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.62Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
15.62Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.62Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
15.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.62Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
15.62Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.62Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
15.62Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
15.38Single4XT1Fractalkine4XT1-US28-Fractalkine
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.38Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
15.38Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.38Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.38Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
15.38Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.38Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.15Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.15Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
15.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.00Single6IQLL7458706IQL-D4-L745870
15.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
15.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.00Single8IHKAcifran8IHK-HCA3-Acifran
15.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8ZPMAMD0708ZPM-CXCR4-AMD070
15.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9BA0A1AKN9BA0-CB1-A1AKN
15.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
15.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
15.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
15.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
15.00Consensussensory_offOrthosteric Ligandopsins_off
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
14.71Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
14.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.29Single4DAJTiotropium4DAJ-M3-Tiotropium
14.29Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
14.29Single5DHGC-355DHG-NOP-C-35
14.29Single5DHHSB-6121115DHH-NOP-SB-612111
14.29Single5TGZAM65385TGZ-CB1-AM6538
14.29Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.29Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.29Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.29Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
14.29Single8K5DGSK2560738K5D-HCA2-GSK256073
14.29Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.29Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.29Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
14.29Single9JEAAtropine9JEA-M1-Atropine
14.29Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
14.29Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
14.29Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.29Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.29Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
14.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.29Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
13.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
13.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
13.89Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.79Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
13.79Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.79Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.79Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.64Single5CGCHTL142425CGC-mGlu5-HTL14242
13.64Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
13.64Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
13.64Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.64Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.64Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
13.64Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
13.64Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
13.64Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
13.64Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.64Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.64Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
13.64Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
13.64Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.64Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
13.64Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.64Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.64Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.64Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.64Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
13.64Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.51Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.51Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
13.33Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
13.33Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
13.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
13.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
13.33Consensuscalcitonin_onOrthosteric Ligandctlike_on
13.33Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
13.04Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
13.04Single5V56TC1145V56-SMO-TC114
13.04Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.04Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.04Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
13.04Single8EA0Iperoxo8EA0-M3-Iperoxo
13.04Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
13.04Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
13.04Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.04Single9AS9RS130-1809AS9-5-HT2A-RS130-180
13.04Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.90Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
12.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.90Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
12.90Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
12.90Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
12.90Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
12.90Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.90Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.90Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.90Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
12.90Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
12.82Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
12.50Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
12.50Single6ZG4HTL00099366ZG4-M1-HTL0009936
12.50Single7DFPSpiperone7DFP-D2-Spiperone
12.50Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.50Single7K15MKD0467K15-BLT1-MKD046-Na
12.50Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
12.50Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
12.50Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.50Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
12.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.50Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
12.50Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
12.50Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
12.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
12.50Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
12.50Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
12.12Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.12Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.12Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.12Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single5CGDHTL142425CGD-mGlu5-HTL14242
12.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
12.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.00Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
12.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
12.00Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
12.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
12.00Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
11.76Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
11.76Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.63Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
11.54Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.43Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
11.43Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single3OE6IT1t3OE6-CXCR4-IT1t
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.11Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
11.11Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.11Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.11Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.11Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
11.11Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
11.11Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
10.81Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.81Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
10.81Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.71Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
10.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.53Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.53Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.53Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.53Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
10.53Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.53Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
10.53Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.53Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
10.53Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
10.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.53Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
10.53Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.53Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.34Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
10.34Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.26Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.00Single3ODUIT1t3ODU-CXCR4-IT1t
10.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.00Single4QINSAG1.54QIN-SMO-SAG1.5
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
10.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
10.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
10.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
10.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
10.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
10.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
10.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
10.00Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
10.00Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
10.00Consensusangiotensin_offOrthosteric Ligandat1_off
10.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.76Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
9.68Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.68Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.68Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
9.52Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.52Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
9.52Single6FFIMMPEP6FFI-mGlu5-MMPEP
9.52Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.52Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
9.52Single6ZG9GSK10347026ZG9-M1-GSK1034702
9.52Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.52Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.52Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
9.52Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
9.52Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
9.38Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
9.38Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
9.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.38Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
9.38Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
9.38Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
9.09Single4YAYZD-71554YAY-AT1-ZD-7155
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single6FFHFenobam6FFH-mGlu5-Fenobam
9.09Single6IIVDaltroban6IIV-TXA2-Daltroban
9.09Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
9.09Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
9.09Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
9.09Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
9.09Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.09Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
9.09Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.09Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Consensusblt_onOrthosteric Ligandblt1_on
9.09Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
9.09Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Consensusleukotriene_onOrthosteric Ligandblt_on
9.09Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.82Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
8.82Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
8.82Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
8.82Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
8.70Single4JKVTaladegib4JKV-SMO-Taladegib
8.70Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.70Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.70Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.70Single7C4SS1P7C4S-S1P3-S1P
8.70Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
8.70Single9HC04YI9HC0-mGlu5-4YI
8.70Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
8.70Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
8.70Consensusblt_offOrthosteric Ligandblt1_off
8.70Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.70Consensusep_offOrthosteric Ligandep4_off
8.70Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.70Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
8.57Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
8.57Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
8.57Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
8.33Single5V57TC1145V57-SMO-TC114
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
8.33Single7P2L4YI7P2L-mGlu5-4YI
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.33Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
8.33Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
8.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.00Single6IIURamatroban6IIU-TXA2-Ramatroban
7.89Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
7.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
7.69Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
7.41Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.14Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
7.14Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
7.14Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
7.14Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
6.90Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
6.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.45Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
6.25Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.06Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
6.06Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
5.88Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.88Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
5.71Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
5.71Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
5.56Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.56Single3OE8IT1t3OE8-CXCR4-IT1t
5.56Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
5.56Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
5.41Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.26Single8JPSCCL78JPS-ACKR1-CCL7
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.00Single6LI0C176LI0-GPR52-C17
5.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.00Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.76Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
4.55Single8K2WAMG4878K2W-CXCR3-AMG487
4.55Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.55Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
4.55Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
4.35Single6GPSMK08126GPS-CCR2-MK0812
4.35Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.35Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
4.35Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.35Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.17Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
4.17Single6GPXMK08126GPX-CCR2-MK0812
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.17Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
3.85Single5X33BIIL2605X33-BLT1-BIIL260
3.85Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.85Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
3.85Single9BJKNAM9BJK-μ-Naloxone-NAM
3.45Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
2.78Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2

PDB Summary
PDB 7Y24
Class A
SubFamily Peptide
Type Somatostatin
SubType SST2
Species Homo Sapiens
Ligand Octreotide
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.25
Date 2022-10-19
D.O.I. doi.org/10.1038/s41589-022-01130-3
Net Summary
Imin 2.89
Number of Linked Nodes 844
Number of Links 1013
Number of Hubs 169
Number of Links mediated by Hubs 625
Number of Communities 27
Number of Nodes involved in Communities 246
Number of Links involved in Communities 352
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 2079462
Length Of Smallest Path 3
Average Path Length 35.8493
Length of Longest Path 73
Minimum Path Strength 1.27
Average Path Strength 6.57165
Maximum Path Strength 22.52
Minimum Path Correlation 0.7
Average Path Correlation 0.990427
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.04082
Average % Of Corr. Nodes 39.0948
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.2779
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDPN
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeDPN
NameD-Phenylalanine
SynonymsD-Phenylalanine
Identifier
FormulaC9 H11 N O2
Molecular Weight165.189
SMILES
PubChem71567
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds23
Total Aromatic Bonds6

CodeDTR
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeDTR
NameD-Tryptophan
Synonyms
  • D-Tryptophan
  • (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
  • (R)-tryptophan
  • DTR
Identifier
FormulaC11 H12 N2 O2
Molecular Weight204.225
SMILES
PubChem6923517
Formal Charge0
Total Atoms27
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>7Y24_Chain_A
LSAEERAAL ERSKAIEKN LKEDGISAA KDVKLLLLG ADNSGKSTI 
VKQMKTGIV ETHFTFKNL HFRLFDVGG QRSERKKWI HCFEDVTAI 
IFCVDLSDY NRMHESLMD FDSICNNKF FIDTSIILF LNKKDLFGE 
KIKKSPLTI CFPEYTGPN TYEDAAAYI QAQFESKNR SPNKEIYCH 
MTCATDTNN AQVIFDAVT DIIIANNLR GCGLY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7Y24_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7Y24_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30874
Sequence
>7Y24_Chain_R
TSNAVLTFI YFVVCIIGL CGNTLVIYV ILRYAKMKT ITNIYILNL 
AIADELFML GLPFLAMQV ALVHWPFGK AICRVVMTV DGINQFTSI 
FCLTVMSID RYLAVVHPI KSAKWRRPR TAKMITMAV WGVSLLVIL 
PIMIYAGLR SNQWGRSSC TINWPGGAW YTGFIIYTF ILGFLVPLT 
IICLCYLFI IIKVKSSGI RVGSSKRKK SEKKVTRMV SIVVAVFIF 
CWLPFYIFN VSSVSMAIS PTPALKGMF DFVVVLTYA NSCANPILY 
AFLSDNFKK SFQNV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XATAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAT (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAUAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ22.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAU (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAVAPeptideSomatostatinSST2Homo sapiensLanreotide-Gi1/β1/γ22.872022-08-31doi.org/10.1038/s41421-022-00405-2
7XAV (No Gprot) APeptideSomatostatinSST2Homo sapiensLanreotide-2.872022-08-31doi.org/10.1038/s41421-022-00405-2
7WICAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIC (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIGAPeptideSomatostatinSST2Homo sapiensL-054,264-Gi1/β1/γ22.72022-06-01doi.org/10.1038/s41422-022-00669-z
7WIG (No Gprot) APeptideSomatostatinSST2Homo sapiensL-054,264-2.72022-06-01doi.org/10.1038/s41422-022-00669-z
7XMRAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XMR (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XN9APeptideSomatostatinSST2Homo sapiensL-054,522--2.62022-08-03doi.org/10.1038/s41422-022-00679-x
7XNAAPeptideSomatostatinSST2Homo sapiensCYN154806--2.652022-08-03doi.org/10.1038/s41422-022-00679-x
7YACAPeptideSomatostatinSST2Homo sapiensPaltusotine-Gi1/β1/γ23.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAC (No Gprot) APeptideSomatostatinSST2Homo sapiensPaltusotine-3.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAEAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ23.372023-04-19doi.org/10.1038/s41467-023-36673-z
7YAE (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.372023-04-19doi.org/10.1038/s41467-023-36673-z
7Y24APeptideSomatostatinSST2Homo sapiensOctreotide-Go/β1/γ23.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y24 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26APeptideSomatostatinSST2Homo sapiensOctreotide-chim(NtGi2L-Gs-CtGq)/β1/γ23.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27APeptideSomatostatinSST2Homo sapiensSomatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ23.482022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.482022-10-19doi.org/10.1038/s41589-022-01130-3
7UL5APeptideSomatostatinSST2Homo sapiens---3.12022-06-29doi.org/10.1038/s41594-022-00859-8
7WJ5APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.722022-07-13doi.org/10.7554/eLife.76823
7WJ5 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.722022-07-13doi.org/10.7554/eLife.76823
7T10APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi3/β1/γ22.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T10 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T11APeptideSomatostatinSST2Homo sapiensOctreotide-Gi3/β1/γ22.72022-03-09doi.org/10.1038/s41594-022-00727-5
7T11 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.72022-03-09doi.org/10.1038/s41594-022-00727-5




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