psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L40	R:R:T41	7.37	No	No	0	2	4
2	R:R:L46	R:R:V103	5.96	No	No	0	5	4
3	R:R:F51	R:R:T47	3.89	No	No	0	5	5
4	R:R:A104	R:R:T47	5.03	No	No	0	5	5
5	R:R:F48	R:R:V52	7.87	No	No	0	6	5
6	R:R:I49	R:R:V299	4.61	No	Yes	0	5	5
7	R:R:V103	R:R:Y50	7.57	No	Yes	1	4	7
8	R:R:D295	R:R:Y50	3.45	Yes	Yes	1	2	7
9	R:R:V298	R:R:Y50	5.05	No	Yes	1	6	7
10	R:R:V299	R:R:Y50	17.66	Yes	Yes	0	5	7
11	R:R:A100	R:R:F51	4.16	No	No	0	6	5
12	R:R:V299	R:R:V53	4.81	Yes	No	0	5	7
13	R:R:C54	R:R:L96	6.35	No	No	1	6	7
14	R:R:C54	R:R:P97	3.77	No	No	1	6	8
15	R:R:C306	R:R:I56	4.91	No	No	0	8	4
16	R:R:G57	R:R:M93	3.49	No	Yes	6	8	6
17	R:R:C306	R:R:G57	3.92	No	No	6	8	8
18	R:R:C59	R:R:G60	3.92	No	No	0	5	8
19	R:R:D89	R:R:N61	6.73	Yes	No	2	9	9
20	R:R:E90	R:R:N61	5.26	No	No	0	7	9
21	R:R:N61	R:R:P309	6.52	No	Yes	2	9	9
22	R:R:A86	R:R:I65	3.25	No	No	0	9	7
23	R:R:E90	R:R:I65	6.83	No	No	0	7	7
24	R:R:R70	R:R:Y66	11.32	No	No	0	4	3
25	R:R:F319	R:R:V67	9.18	No	Yes	0	8	7
26	R:R:I68	R:R:L83	4.28	Yes	No	0	7	6
27	R:R:F319	R:R:I68	3.77	No	Yes	0	8	7
28	R:R:L69	R:R:L83	4.15	No	No	0	3	6
29	R:R:N79	R:R:T76	10.24	No	No	0	8	7
30	R:R:I77	R:R:Y81	4.84	No	Yes	2	4	7
31	R:R:D139	R:R:I77	4.2	No	No	2	8	4
32	R:R:A159	R:R:I77	4.87	No	No	0	7	4
33	R:R:A159	R:R:I80	4.87	No	No	0	7	5
34	R:R:V135	R:R:Y81	6.31	No	Yes	2	7	7
35	R:R:M136	R:R:Y81	4.79	No	Yes	2	9	7
36	R:R:D139	R:R:Y81	10.34	No	Yes	2	8	7
37	R:R:I162	R:R:Y81	3.63	No	Yes	2	5	7
38	R:R:A313	R:R:I82	4.87	No	Yes	0	7	8
39	R:R:C132	R:R:N84	6.3	No	No	0	8	9
40	R:R:N84	R:R:T163	7.31	No	No	0	9	7
41	R:R:N84	R:R:W167	9.04	No	Yes	0	9	9
42	R:R:D89	R:R:L85	8.14	Yes	Yes	2	9	9
43	R:R:L85	R:R:M136	5.65	Yes	No	2	9	9
44	R:R:L85	R:R:N308	5.49	Yes	Yes	2	9	9
45	R:R:L85	R:R:Y312	3.52	Yes	Yes	2	9	9
46	R:R:D89	R:R:S129	5.89	Yes	No	0	9	9
47	R:R:D89	R:R:S305	10.31	Yes	No	0	9	8
48	R:R:D89	R:R:N308	10.77	Yes	Yes	2	9	9
49	R:R:D89	R:R:P309	3.22	Yes	Yes	2	9	9
50	R:R:L91	R:R:N125	9.61	No	Yes	0	7	7
51	R:R:D122	R:R:F92	4.78	Yes	Yes	1	6	6
52	R:R:F92	R:R:N125	4.83	Yes	Yes	0	6	7
53	R:R:F92	R:R:Q126	8.2	Yes	Yes	1	6	7
54	R:R:F92	R:R:Y302	19.6	Yes	Yes	1	6	7
55	R:R:F92	R:R:S305	5.28	Yes	No	0	6	8
56	R:R:M93	R:R:S305	3.07	Yes	No	0	6	8
57	R:R:C306	R:R:M93	3.24	No	Yes	6	8	6
58	R:R:L96	R:R:P97	3.28	No	No	1	7	8
59	R:R:L96	R:R:Y302	5.86	No	Yes	1	7	7
60	R:R:F98	R:R:V118	6.55	No	No	0	5	5
61	R:R:L99	R:R:Q102	3.99	No	No	0	6	5
62	R:R:F110	R:R:M101	4.98	Yes	No	0	6	5
63	R:R:Q102	R:R:W108	7.67	No	Yes	0	5	8
64	R:R:D295	R:R:V103	5.84	Yes	No	1	2	4
65	R:R:H107	R:R:L105	7.71	No	No	0	4	5
66	R:R:H107	R:R:P109	9.15	No	No	0	4	4
67	R:R:F110	R:R:W108	11.02	Yes	Yes	0	6	8
68	R:R:C115	R:R:W108	6.53	No	Yes	5	9	8
69	R:R:L183	R:R:W108	3.42	No	Yes	5	4	8
70	R:R:C193	R:R:W108	16.98	No	Yes	5	9	8
71	R:R:C115	R:R:L183	3.17	No	No	5	9	4
72	R:R:C115	R:R:C193	7.28	No	No	5	9	9
73	R:R:A181	R:R:M119	3.22	No	Yes	0	4	5
74	R:R:C193	R:R:M119	4.86	No	Yes	0	9	5
75	L:L:?1	R:R:M119	3.39	Yes	Yes	0	0	5
76	R:R:M178	R:R:T120	9.03	No	No	0	5	6
77	R:R:D122	R:R:Q126	3.92	Yes	Yes	1	6	7
78	R:R:D122	R:R:Y302	8.05	Yes	Yes	1	6	7
79	L:L:?1	R:R:D122	13.02	Yes	Yes	1	0	6
80	R:R:G123	R:R:I174	3.53	No	Yes	0	4	7
81	R:R:I124	R:R:W167	4.7	No	Yes	4	5	9
82	R:R:I124	R:R:S170	4.64	No	No	4	5	7
83	R:R:N125	R:R:W167	3.39	Yes	Yes	0	7	9
84	R:R:F127	R:R:Q126	9.37	Yes	Yes	0	6	7
85	R:R:Q126	R:R:W269	5.48	Yes	Yes	0	7	8
86	L:L:?1	R:R:Q126	9.58	Yes	Yes	1	0	7
87	R:R:F127	R:R:V173	3.93	Yes	No	0	6	4
88	R:R:F127	R:R:I174	3.77	Yes	Yes	0	6	7
89	R:R:T128	R:R:W167	21.83	No	Yes	4	7	9
90	R:R:S170	R:R:T128	7.99	No	No	4	7	7
91	R:R:I130	R:R:P220	3.39	No	No	0	8	9
92	R:R:I130	R:R:W269	10.57	No	Yes	0	8	8
93	R:R:F131	R:R:V166	3.93	No	No	0	6	6
94	R:R:F131	R:R:L215	4.87	No	No	0	6	4
95	R:R:L133	R:R:Y312	9.38	No	Yes	0	9	9
96	R:R:P220	R:R:T134	3.5	No	No	0	9	7
97	R:R:I223	R:R:T134	4.56	Yes	No	0	6	7
98	R:R:I162	R:R:V135	3.07	No	No	2	5	7
99	R:R:M136	R:R:Y312	4.79	No	Yes	2	9	9
100	R:R:I224	R:R:S137	9.29	No	No	7	7	9
101	R:R:S137	R:R:Y228	7.63	No	Yes	7	9	9
102	R:R:D139	R:R:R154	13.1	No	No	0	8	5
103	R:R:R140	R:R:Y228	8.23	No	Yes	0	9	9
104	R:R:R140	R:R:Y312	7.2	No	Yes	0	9	9
105	R:R:V145	R:R:Y141	12.62	No	Yes	8	7	8
106	R:R:H146	R:R:Y141	3.27	Yes	Yes	8	5	8
107	R:R:C227	R:R:Y141	8.06	No	Yes	0	7	8
108	R:R:F230	R:R:Y141	6.19	No	Yes	0	4	8
109	R:R:L142	R:R:S150	7.51	No	No	0	4	5
110	R:R:A143	R:R:R154	5.53	No	No	0	8	5
111	R:R:I231	R:R:V144	4.61	No	No	0	9	8
112	R:R:H146	R:R:V145	8.3	Yes	No	8	5	7
113	R:R:K234	R:R:P147	3.35	No	No	0	5	8
114	R:R:T158	R:R:W153	6.06	No	No	0	5	3
115	R:R:R155	R:R:T158	5.17	No	No	0	6	5
116	R:R:M161	R:R:R157	3.72	No	No	0	1	4
117	R:R:S170	R:R:W167	3.71	No	Yes	4	7	9
118	R:R:V173	R:R:Y211	3.79	No	No	3	4	4
119	R:R:L215	R:R:V173	4.47	No	No	3	4	4
120	R:R:I174	R:R:I177	7.36	Yes	No	0	7	3
121	R:R:I174	R:R:M178	4.37	Yes	No	0	7	5
122	R:R:P176	R:R:W197	4.05	No	Yes	3	8	5
123	R:R:F208	R:R:P176	5.78	Yes	No	3	7	8
124	R:R:I177	R:R:I195	5.89	No	No	0	3	5
125	R:R:F208	R:R:I177	3.77	Yes	No	0	7	3
126	R:R:I179	R:R:Y180	15.71	No	No	0	4	4
127	R:R:W197	R:R:Y180	12.54	Yes	No	3	5	4
128	R:R:P198	R:R:Y180	6.95	No	No	3	5	4
129	R:R:L183	R:R:S191	4.5	No	No	0	4	5
130	R:R:S185	R:R:S191	3.26	No	No	0	2	5
131	R:R:N186	R:R:W188	5.65	No	No	9	1	2
132	R:R:N186	R:R:R190	3.62	No	Yes	9	1	1
133	R:R:R190	R:R:W188	6	Yes	No	9	1	2
134	R:R:I195	R:R:W197	9.4	No	Yes	0	5	5
135	R:R:P198	R:R:W197	4.05	No	Yes	3	5	5
136	R:R:W197	R:R:W204	12.18	Yes	No	0	5	3
137	R:R:F208	R:R:W197	14.03	Yes	Yes	3	7	5
138	R:R:V280	R:R:Y205	7.57	No	No	0	4	4
139	R:R:G207	R:R:T206	3.64	No	No	0	4	3
140	R:R:T206	R:R:V280	3.17	No	No	0	3	4
141	R:R:F208	R:R:Y211	4.13	Yes	No	3	7	4
142	R:R:F208	R:R:T212	7.78	Yes	No	0	7	4
143	R:R:I209	R:R:V277	3.07	No	No	0	5	5
144	R:R:I209	R:R:V280	10.75	No	No	0	5	4
145	R:R:L215	R:R:Y211	4.69	No	No	3	4	4
146	R:R:F213	R:R:F217	8.57	No	No	1	5	8
147	R:R:F213	R:R:Y273	11.35	No	Yes	1	5	7
148	R:R:F217	R:R:L270	6.09	No	No	0	8	5
149	R:R:F217	R:R:Y273	4.13	No	Yes	1	8	7
150	R:R:P220	R:R:V219	3.53	No	No	0	9	5
151	R:R:I223	R:R:V219	3.07	Yes	No	0	6	5
152	R:R:C225	R:R:L221	3.17	No	No	0	5	6
153	R:R:F265	R:R:L221	3.65	No	No	0	9	6
154	R:R:I266	R:R:L221	5.71	No	No	0	6	6
155	R:R:I224	R:R:Y228	3.63	No	Yes	7	7	9
156	R:R:V258	R:R:Y228	12.62	No	Yes	0	8	9
157	R:R:I232	R:R:T255	4.56	No	No	0	5	7
158	R:R:K234	R:R:S238	4.59	No	No	0	5	5
159	R:R:E251	R:R:K236	10.8	No	No	0	6	4
160	R:R:I240	R:R:R247	8.77	No	No	0	3	4
161	R:R:S244	R:R:V242	3.23	No	No	0	3	3
162	R:R:E251	R:R:R247	9.3	No	No	0	6	4
163	R:R:K253	R:R:M257	7.2	No	No	0	7	8
164	R:R:I266	R:R:V262	3.07	No	No	0	6	7
165	R:R:L311	R:R:V264	4.47	No	No	0	8	7
166	R:R:F265	R:R:W269	13.03	No	Yes	0	9	8
167	R:R:C268	R:R:L300	4.76	Yes	No	0	8	7
168	R:R:W269	R:R:Y273	3.86	Yes	Yes	0	8	7
169	R:R:T301	R:R:W269	7.28	No	Yes	0	7	8
170	R:R:N304	R:R:W269	13.56	No	Yes	0	9	8
171	R:R:L270	R:R:P271	3.28	No	No	0	5	9
172	R:R:I274	R:R:L270	4.28	No	No	0	5	5
173	R:R:P271	R:R:V297	5.3	No	No	0	9	7
174	R:R:F272	R:R:Y273	4.13	Yes	Yes	1	6	7
175	R:R:F272	R:R:N276	15.71	Yes	No	1	6	6
176	R:R:F272	R:R:F294	3.22	Yes	Yes	1	6	4
177	L:L:?1	R:R:F272	12.66	Yes	Yes	1	0	6
178	R:R:F275	R:R:L290	3.65	Yes	Yes	1	4	4
179	R:R:F275	R:R:F294	5.36	Yes	Yes	1	4	4
180	L:L:?1	R:R:F275	6.82	Yes	Yes	1	0	4
181	L:L:?1	R:R:N276	8.78	Yes	No	1	0	6
182	L:L:?1	R:R:S279	6	Yes	No	0	0	4
183	R:R:P286	R:R:S285	3.56	No	No	0	2	2
184	R:R:P288	R:R:T287	3.5	No	No	0	3	1
185	R:R:L290	R:R:T287	7.37	Yes	No	0	4	1
186	L:L:?1	R:R:L290	3.32	Yes	Yes	1	0	4
187	R:R:D295	R:R:K291	4.15	Yes	No	0	2	3
188	R:R:F294	R:R:V298	6.55	Yes	No	1	4	6
189	L:L:?1	R:R:F294	29.22	Yes	Yes	1	0	4
190	L:L:?1	R:R:V298	4.76	Yes	No	1	0	6
191	L:L:?1	R:R:Y302	6.56	Yes	Yes	1	0	7
192	R:R:N304	R:R:N308	9.54	No	Yes	0	9	9
193	R:R:N308	R:R:P309	6.52	Yes	Yes	2	9	9
194	R:R:F314	R:R:I310	5.02	No	No	0	7	6
195	R:R:F314	R:R:F323	4.29	No	No	0	7	6
196	R:R:F319	R:R:F323	4.29	No	No	0	8	6
197	R:R:F323	R:R:L327	7.31	No	No	0	6	7
198	R:R:N325	R:R:V326	4.43	No	No	0	4	5
199	R:R:I82	R:R:T78	3.04	Yes	No	0	8	8
200	R:R:M119	R:R:V118	3.04	Yes	No	0	5	5
201	R:R:K234	R:R:V145	3.04	No	No	0	5	7
202	R:R:M161	R:R:T158	3.01	No	No	0	1	5
203	R:R:G239	R:R:R247	3	No	No	0	5	4
204	R:R:N125	R:R:V121	2.96	Yes	No	0	7	5
205	R:R:L226	R:R:T222	2.95	No	No	0	5	4
206	R:R:I65	R:R:I87	2.94	No	No	0	7	7
207	R:R:I68	R:R:I82	2.94	Yes	Yes	2	7	8
208	R:R:I138	R:R:I223	2.94	No	Yes	0	6	6
209	R:R:I210	R:R:I214	2.94	No	No	0	5	4
210	R:R:Q102	R:R:S192	2.89	No	No	0	5	4
211	R:R:F110	R:R:P109	2.89	Yes	No	0	6	4
212	R:R:W197	R:R:Y205	2.89	Yes	No	0	5	4
213	R:R:P156	R:R:R155	2.88	No	No	0	3	6
214	R:R:I124	R:R:L171	2.85	No	No	0	5	3
215	R:R:L58	R:R:M93	2.83	No	Yes	0	6	6
216	R:R:L175	R:R:M178	2.83	No	No	0	4	5
217	R:R:L315	R:R:M257	2.83	No	No	0	6	8
218	R:R:H146	R:R:S150	2.79	Yes	No	0	5	5
219	R:R:A100	R:R:Y50	2.67	No	Yes	0	6	7
220	R:R:F275	R:R:S278	2.64	Yes	No	0	4	4
221	R:R:F131	R:R:V169	2.62	No	No	0	6	4
222	R:R:V261	R:R:Y312	2.52	No	Yes	0	8	9
223	R:R:F98	R:R:I114	2.51	No	No	0	5	6
224	R:R:F110	R:R:I114	2.51	Yes	No	0	6	6
225	R:R:I260	R:R:R256	2.51	No	No	0	6	6
226	R:R:F314	R:R:L315	2.44	No	No	0	7	6
227	R:R:I231	R:R:Y228	2.42	No	Yes	0	9	9
228	R:R:L142	R:R:W153	2.28	No	No	0	4	3
229	R:R:H107	R:R:R190	2.26	No	Yes	0	4	1
230	R:R:G95	R:R:P97	2.03	No	No	0	6	8
231	R:R:A181	R:R:G182	1.95	No	No	0	4	5
232	R:R:G239	R:R:V242	1.84	No	No	0	5	3
233	R:R:G243	R:R:V242	1.84	No	No	0	1	3
234	R:R:P309	R:R:V64	1.77	Yes	No	2	9	9
235	R:R:C227	R:R:S137	1.72	No	No	0	7	9
236	R:R:A88	R:R:S129	1.71	No	No	0	8	9
237	R:R:G168	R:R:L171	1.71	No	No	0	4	3
238	R:R:C268	R:R:V264	1.71	Yes	No	0	8	7
239	R:R:A289	R:R:T287	1.68	No	No	0	1	1
240	R:R:D295	R:R:G292	1.68	Yes	No	0	2	1
241	R:R:C59	R:R:I56	1.64	No	No	0	5	4
242	R:R:E200	R:R:G199	1.64	No	No	0	4	3
243	R:R:S322	R:R:V67	1.62	No	Yes	0	5	7
244	R:R:A289	R:R:M293	1.61	No	No	0	1	4
245	R:R:V144	R:R:V235	1.6	No	No	0	8	8
246	R:R:V254	R:R:V258	1.6	No	No	0	8	8
247	R:R:S259	R:R:T255	1.6	No	No	0	4	7
248	R:R:T41	R:R:V45	1.59	No	No	0	4	5
249	R:R:A303	R:R:L300	1.58	No	No	0	5	7
250	R:R:T76	R:R:T78	1.57	No	No	0	7	8
251	R:R:C268	R:R:N304	1.57	Yes	No	0	8	9
252	R:R:A44	R:R:N43	1.56	No	No	0	4	3
253	R:R:I68	R:R:V64	1.54	Yes	No	2	7	9
254	R:R:I82	R:R:V64	1.54	Yes	No	2	8	9
255	R:R:I260	R:R:V264	1.54	No	No	0	6	7
256	R:R:I195	R:R:T194	1.52	No	No	0	5	4
257	R:R:I223	R:R:T222	1.52	Yes	No	0	6	4
258	R:R:F127	R:R:G216	1.51	Yes	No	0	6	6
259	R:R:M164	R:R:T163	1.51	No	No	0	4	7
260	R:R:K160	R:R:T163	1.5	No	No	0	1	7
261	R:R:G189	R:R:R190	1.5	No	Yes	0	6	1
262	R:R:L63	R:R:V67	1.49	No	Yes	0	6	7
263	R:R:N318	R:R:S316	1.49	No	No	0	5	8
264	R:R:L327	R:R:V326	1.49	No	No	0	7	5
265	R:R:I209	R:R:I210	1.47	No	No	0	5	5
266	R:R:I284	R:R:M282	1.46	No	No	0	1	3
267	R:R:E251	R:R:S250	1.44	No	No	0	6	5
268	R:R:I214	R:R:L218	1.43	No	No	0	4	4
269	R:R:I233	R:R:L229	1.43	No	No	0	3	4
270	R:R:I284	R:R:L290	1.43	No	Yes	0	1	4
271	R:R:C268	R:R:F267	1.4	Yes	No	0	8	6
272	R:R:L58	R:R:L94	1.38	No	No	0	6	5
273	R:R:A181	R:R:R116	1.38	No	No	0	4	6
274	R:R:K320	R:R:Q324	1.36	No	No	0	8	4
275	R:R:R241	R:R:S238	1.32	No	No	0	1	5
276	R:R:R190	R:R:V106	1.31	Yes	No	0	1	4
277	R:R:H146	R:R:K149	1.31	Yes	No	0	5	4
278	R:R:F296	R:R:V297	1.31	No	No	0	5	7
279	R:R:F296	R:R:V299	1.31	No	Yes	0	5	5
280	R:R:R184	R:R:T194	1.29	No	No	0	2	4
281	R:R:V67	R:R:Y66	1.26	Yes	No	0	7	3
282	R:R:V326	R:R:Y66	1.26	No	No	0	5	3
283	R:R:F230	R:R:I233	1.26	No	No	0	4	3
284	R:R:K112	R:R:R116	1.24	No	No	0	3	6
285	R:R:S201	R:R:W204	1.24	No	No	0	2	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y50	7.28	5	1	7
2	R:R:V67	3.3875	4	0	7
3	R:R:I68	3.1325	4	2	7
4	R:R:Y81	5.982	5	2	7
5	R:R:I82	3.0975	4	2	8
6	R:R:L85	5.7	4	2	9
7	R:R:D89	7.51	6	2	9
8	R:R:F92	8.538	5	1	6
9	R:R:M93	3.1575	4	6	6
10	R:R:W108	9.124	5	5	8
11	R:R:F110	5.35	4	0	6
12	R:R:M119	3.6275	4	0	5
13	R:R:D122	7.4425	4	1	6
14	R:R:N125	5.1975	4	0	7
15	R:R:Q126	7.31	5	1	7
16	R:R:F127	4.645	4	0	6
17	R:R:Y141	7.535	4	8	8
18	R:R:H146	3.9175	4	8	5
19	R:R:W167	8.534	5	4	9
20	R:R:I174	4.7575	4	0	7
21	R:R:R190	2.938	5	9	1
22	R:R:W197	8.44857	7	3	5
23	R:R:F208	7.098	5	3	7
24	R:R:I223	3.0225	4	0	6
25	R:R:Y228	6.906	5	7	9
26	R:R:C268	2.36	4	0	8
27	R:R:W269	8.96333	6	0	8
28	R:R:F272	8.93	4	1	6
29	R:R:Y273	5.8675	4	1	7
30	R:R:F275	4.6175	4	1	4
31	R:R:L290	3.9425	4	1	4
32	R:R:F294	11.0875	4	1	4
33	R:R:D295	3.78	4	1	2
34	R:R:V299	7.0975	4	0	5
35	R:R:Y302	10.0175	4	1	7
36	R:R:N308	8.08	4	2	9
37	R:R:P309	4.5075	4	2	9
38	R:R:Y312	5.482	5	2	9
39	L:L:?1	9.46455	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V299	R:R:Y50	10.4204	17.66	Yes	Yes	0	5	7
2	R:R:V298	R:R:Y50	32.8522	5.05	No	Yes	1	6	7
3	L:L:?1	R:R:Y302	29.1092	6.56	Yes	Yes	1	0	7
4	L:L:?1	R:R:V298	34.5433	4.76	Yes	No	1	0	6
5	R:R:M93	R:R:S305	13.3852	3.07	Yes	No	0	6	8
6	R:R:F92	R:R:S305	100	5.28	Yes	No	0	6	8
7	R:R:D122	R:R:F92	26.0531	4.78	Yes	Yes	1	6	6
8	L:L:?1	R:R:D122	25.8531	13.02	Yes	Yes	1	0	6
9	R:R:F92	R:R:Q126	61.3746	8.2	Yes	Yes	1	6	7
10	L:L:?1	R:R:Q126	70.0517	9.58	Yes	Yes	1	0	7
11	R:R:F92	R:R:Y302	29.9526	19.6	Yes	Yes	1	6	7
12	R:R:D89	R:R:S305	91.8619	10.31	Yes	No	0	9	8
13	R:R:D89	R:R:P309	36.9343	3.22	Yes	Yes	2	9	9
14	R:R:Q126	R:R:W269	61.5441	5.48	Yes	Yes	0	7	8
15	R:R:N304	R:R:W269	56.8187	13.56	No	Yes	0	9	8
16	R:R:N304	R:R:N308	53.1018	9.54	No	Yes	0	9	9
17	R:R:N308	R:R:P309	25.1924	6.52	Yes	Yes	2	9	9
18	R:R:P309	R:R:V64	59.7053	1.77	Yes	No	2	9	9
19	R:R:I68	R:R:V64	45.8375	1.54	Yes	No	2	7	9
20	R:R:F319	R:R:I68	39.4079	3.77	No	Yes	0	8	7
21	R:R:F319	R:R:V67	16.4587	9.18	No	Yes	0	8	7
22	R:R:I82	R:R:V64	11.6463	1.54	Yes	No	2	8	9
23	R:R:M136	R:R:Y81	20.9668	4.79	No	Yes	2	9	7
24	R:R:L85	R:R:M136	21.8624	5.65	Yes	No	2	9	9
25	R:R:D89	R:R:L85	56.6361	8.14	Yes	Yes	2	9	9
26	R:R:L85	R:R:N308	35.8736	5.49	Yes	Yes	2	9	9
27	R:R:N125	R:R:W167	18.2628	3.39	Yes	Yes	0	7	9
28	R:R:F92	R:R:N125	23.0622	4.83	Yes	Yes	0	6	7
29	R:R:L85	R:R:Y312	68.6476	3.52	Yes	Yes	2	9	9
30	L:L:?1	R:R:M119	66.9	3.39	Yes	Yes	0	0	5
31	R:R:C193	R:R:M119	49.6631	4.86	No	Yes	0	9	5
32	R:R:C193	R:R:W108	38.608	16.98	No	Yes	5	9	8
33	R:R:F110	R:R:W108	23.11	11.02	Yes	Yes	0	6	8
34	R:R:H107	R:R:P109	16.3066	9.15	No	No	0	4	4
35	R:R:F110	R:R:P109	18.6019	2.89	Yes	No	0	6	4
36	R:R:F127	R:R:Q126	83.6543	9.37	Yes	Yes	0	6	7
37	R:R:F127	R:R:I174	52.1932	3.77	Yes	Yes	0	6	7
38	R:R:F127	R:R:V173	29.8483	3.93	Yes	No	0	6	4
39	R:R:I130	R:R:W269	14.4981	10.57	No	Yes	0	8	8
40	R:R:I130	R:R:P220	13.3374	3.39	No	No	0	8	9
41	R:R:R140	R:R:Y228	61.9571	8.23	No	Yes	0	9	9
42	R:R:R140	R:R:Y312	63.8438	7.2	No	Yes	0	9	9
43	R:R:S137	R:R:Y228	47.2547	7.63	No	Yes	7	9	9
44	R:R:C227	R:R:S137	45.155	1.72	No	No	0	7	9
45	R:R:C227	R:R:Y141	42.9553	8.06	No	Yes	0	7	8
46	R:R:V145	R:R:Y141	11.2724	12.62	No	Yes	8	7	8
47	R:R:H146	R:R:Y141	22.7927	3.27	Yes	Yes	8	5	8
48	R:R:L142	R:R:S150	16.1196	7.51	No	No	0	4	5
49	R:R:H146	R:R:S150	18.4237	2.79	Yes	No	0	5	5
50	R:R:L142	R:R:W153	13.8069	2.28	No	No	0	4	3
51	R:R:T158	R:R:W153	11.4855	6.06	No	No	0	5	3
52	R:R:V173	R:R:Y211	23.5839	3.79	No	No	3	4	4
53	R:R:I174	R:R:I177	46.6504	7.36	Yes	No	0	7	3
54	R:R:F208	R:R:Y211	22.997	4.13	Yes	No	3	7	4
55	R:R:F208	R:R:I177	22.9448	3.77	Yes	No	0	7	3
56	R:R:F208	R:R:W197	38.308	14.03	Yes	Yes	3	7	5
57	R:R:I177	R:R:I195	22.8057	5.89	No	No	0	3	5
58	R:R:I195	R:R:W197	19.1801	9.4	No	Yes	0	5	5
59	R:R:H107	R:R:R190	11.6898	2.26	No	Yes	0	4	1
60	R:R:W197	R:R:Y205	34.7303	2.89	Yes	No	0	5	4
61	R:R:V280	R:R:Y205	31.0177	7.57	No	No	0	4	4
62	R:R:I209	R:R:V280	19.4496	10.75	No	No	0	5	4
63	R:R:F314	R:R:F323	11.8072	4.29	No	No	0	7	6
64	R:R:F319	R:R:F323	21.2016	4.29	No	No	0	8	6
65	L:L:?1	R:R:L290	15.9023	3.32	Yes	Yes	1	0	4
66	R:R:I209	R:R:I210	11.6941	1.47	No	No	0	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V298	R:R:Y50	5.05	1	No	Yes	6	7	1	2
R:R:D122	R:R:F92	4.78	1	Yes	Yes	6	6	1	2
R:R:F92	R:R:Q126	8.2	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	19.6	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	5.86	1	No	Yes	7	7	2	1
R:R:A181	R:R:M119	3.22	0	No	Yes	4	5	2	1
R:R:C193	R:R:M119	4.86	5	No	Yes	9	5	2	1
L:L:?1	R:R:M119	3.39	1	Yes	Yes	0	5	0	1
R:R:D122	R:R:Q126	3.92	1	Yes	Yes	6	7	1	1
R:R:D122	R:R:Y302	8.05	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:D122	13.02	1	Yes	Yes	0	6	0	1
R:R:F127	R:R:Q126	9.37	0	Yes	Yes	6	7	2	1
R:R:Q126	R:R:W269	5.48	1	Yes	Yes	7	8	1	2
L:L:?1	R:R:Q126	9.58	1	Yes	Yes	0	7	0	1
R:R:W269	R:R:Y273	3.86	0	Yes	Yes	8	7	2	2
R:R:F272	R:R:Y273	4.13	1	Yes	Yes	6	7	1	2
R:R:F272	R:R:N276	15.71	1	Yes	No	6	6	1	1
R:R:F272	R:R:F294	3.22	1	Yes	Yes	6	4	1	1
L:L:?1	R:R:F272	12.66	1	Yes	Yes	0	6	0	1
R:R:F275	R:R:L290	3.65	1	Yes	Yes	4	4	1	1
R:R:F275	R:R:F294	5.36	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:F275	6.82	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:N276	8.78	1	Yes	No	0	6	0	1
L:L:?1	R:R:S279	6	1	Yes	No	0	4	0	1
R:R:L290	R:R:T287	7.37	1	Yes	No	4	1	1	2
L:L:?1	R:R:L290	3.32	1	Yes	Yes	0	4	0	1
R:R:F294	R:R:V298	6.55	1	Yes	No	4	6	1	1
L:L:?1	R:R:F294	29.22	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V298	4.76	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y302	6.56	1	Yes	Yes	0	7	0	1
R:R:M119	R:R:V118	3.04	0	Yes	No	5	5	1	2
R:R:F275	R:R:S278	2.64	1	Yes	No	4	4	1	2
R:R:I284	R:R:L290	1.43	0	No	Yes	1	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WIG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	257
Number of Links	285
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	9
Number of Nodes involved in Communities	63
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	58082
Length Of Smallest Path	3
Average Path Length	12.7934
Length of Longest Path	29
Minimum Path Strength	1.26
Average Path Strength	6.2947
Maximum Path Strength	19
Minimum Path Correlation	0.7
Average Path Correlation	0.921447
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	48.018
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.7986
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9FI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9FI
Name	~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide
Synonyms
Identifier
Formula	C33 H41 N5 O2
Molecular Weight	539.711
SMILES
PubChem	9915239
Formal Charge	0
Total Atoms	81
Total Chiral Atoms	3
Total Bonds	86
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7WIG_nogp_Chain_R L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.