psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G2	R:R:Y205	4.35	No	Yes	0	0	4
2	L:L:C14	L:L:C3	7.28	No	No	0	0	0
3	L:L:K4	R:R:Y205	17.91	No	Yes	0	0	4
4	L:L:N5	R:R:P286	3.26	No	No	0	0	2
5	L:L:F11	L:L:F6	4.29	Yes	Yes	0	0	0
6	L:L:F6	R:R:F275	13.93	Yes	Yes	4	0	4
7	L:L:F6	R:R:F294	12.86	Yes	No	4	0	4
8	L:L:F7	L:L:W8	3.01	Yes	Yes	1	0	0
9	L:L:F7	R:R:I195	6.28	Yes	No	1	0	5
10	L:L:F7	R:R:W197	4.01	Yes	Yes	1	0	5
11	L:L:F7	R:R:Y205	11.35	Yes	Yes	1	0	4
12	L:L:F7	R:R:I209	5.02	Yes	Yes	0	0	5
13	L:L:K9	L:L:W8	4.64	Yes	Yes	1	0	0
14	L:L:W8	R:R:Q126	7.67	Yes	Yes	1	0	7
15	L:L:W8	R:R:T212	9.7	Yes	No	0	0	4
16	L:L:W8	R:R:F272	6.01	Yes	Yes	1	0	6
17	L:L:K9	R:R:D122	5.53	Yes	No	1	0	6
18	L:L:K9	R:R:Q126	5.42	Yes	Yes	1	0	7
19	L:L:K9	R:R:F272	4.96	Yes	Yes	1	0	6
20	L:L:K9	R:R:Y302	8.36	Yes	Yes	1	0	7
21	L:L:T10	R:R:Q102	7.09	No	Yes	0	0	5
22	L:L:T10	R:R:T194	7.85	No	No	0	0	4
23	L:L:F11	R:R:K291	12.41	Yes	No	0	0	3
24	L:L:T12	R:R:S192	6.4	No	No	5	0	4
25	L:L:T12	R:R:T194	4.71	No	No	5	0	4
26	R:R:L40	R:R:S42	9.01	No	No	0	2	4
27	R:R:D295	R:R:L46	8.14	Yes	No	0	2	5
28	R:R:A104	R:R:T47	3.36	No	No	0	5	5
29	R:R:F48	R:R:V52	6.55	No	No	0	6	5
30	R:R:L96	R:R:Y50	3.52	Yes	Yes	0	7	7
31	R:R:L99	R:R:Y50	4.69	No	Yes	0	6	7
32	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
33	R:R:V299	R:R:Y50	5.05	Yes	Yes	0	5	7
34	R:R:F51	R:R:P97	2.89	No	No	0	5	8
35	R:R:C54	R:R:L58	3.17	No	No	0	6	6
36	R:R:C54	R:R:L96	3.17	No	Yes	1	6	7
37	R:R:C54	R:R:P97	5.65	No	No	1	6	8
38	R:R:C306	R:R:I56	3.27	No	No	0	8	4
39	R:R:G57	R:R:M93	3.49	No	Yes	0	8	6
40	R:R:C306	R:R:G57	3.92	No	No	0	8	8
41	R:R:L58	R:R:M93	2.83	No	Yes	0	6	6
42	R:R:C59	R:R:G60	3.92	No	No	0	5	8
43	R:R:D89	R:R:N61	6.73	Yes	Yes	2	9	9
44	R:R:N61	R:R:P309	8.15	Yes	No	2	9	9
45	R:R:F314	R:R:L63	6.09	Yes	No	0	7	6
46	R:R:A313	R:R:V64	3.39	No	No	0	7	9
47	R:R:F314	R:R:V64	3.93	Yes	No	0	7	9
48	R:R:I65	R:R:L69	4.28	No	No	0	7	3
49	R:R:I65	R:R:L83	2.85	No	No	0	7	6
50	R:R:F319	R:R:V67	9.18	Yes	No	0	8	7
51	R:R:I68	R:R:K73	10.18	No	No	7	7	5
52	R:R:F319	R:R:I68	3.77	Yes	No	7	8	7
53	R:R:V326	R:R:Y71	10.09	No	No	0	5	6
54	R:R:K73	R:R:N79	20.98	No	No	0	5	8
55	R:R:F319	R:R:K73	8.69	Yes	No	7	8	5
56	R:R:L83	R:R:M74	7.07	No	No	0	6	7
57	R:R:T76	R:R:T78	4.71	No	No	0	7	8
58	R:R:N79	R:R:T76	10.24	No	No	0	8	7
59	R:R:I77	R:R:Y81	6.04	No	Yes	8	4	7
60	R:R:I77	R:R:P156	5.08	No	No	0	4	3
61	R:R:A159	R:R:I77	3.25	No	No	8	7	4
62	R:R:A159	R:R:I80	3.25	No	No	0	7	5
63	R:R:I80	R:R:K160	2.91	No	No	0	5	1
64	R:R:V135	R:R:Y81	5.05	No	Yes	0	7	7
65	R:R:M136	R:R:Y81	4.79	No	Yes	0	9	7
66	R:R:D139	R:R:Y81	11.49	No	Yes	0	8	7
67	R:R:A159	R:R:Y81	4	No	Yes	8	7	7
68	R:R:N84	R:R:T163	14.62	No	No	0	9	7
69	R:R:N84	R:R:W167	5.65	No	Yes	0	9	9
70	R:R:D89	R:R:L85	9.5	Yes	Yes	2	9	9
71	R:R:L85	R:R:S129	3	Yes	No	2	9	9
72	R:R:L85	R:R:M136	5.65	Yes	No	0	9	9
73	R:R:L85	R:R:N308	10.98	Yes	Yes	2	9	9
74	R:R:I87	R:R:W167	3.52	No	Yes	0	7	9
75	R:R:D89	R:R:S129	4.42	Yes	No	2	9	9
76	R:R:D89	R:R:S305	8.83	Yes	No	0	9	8
77	R:R:D89	R:R:N308	8.08	Yes	Yes	2	9	9
78	R:R:D89	R:R:P309	3.22	Yes	No	2	9	9
79	R:R:L91	R:R:N125	6.87	No	Yes	0	7	7
80	R:R:F92	R:R:N125	6.04	Yes	Yes	0	6	7
81	R:R:F92	R:R:Q126	3.51	Yes	Yes	0	6	7
82	R:R:F92	R:R:Y302	29.91	Yes	Yes	0	6	7
83	R:R:F92	R:R:S305	3.96	Yes	No	0	6	8
84	R:R:M93	R:R:Y302	3.59	Yes	Yes	0	6	7
85	R:R:M93	R:R:S305	3.07	Yes	No	0	6	8
86	R:R:F98	R:R:G95	3.01	No	No	0	5	6
87	R:R:L96	R:R:P97	3.28	Yes	No	1	7	8
88	R:R:L96	R:R:Y302	12.89	Yes	Yes	1	7	7
89	R:R:F110	R:R:F98	3.22	Yes	No	0	6	5
90	R:R:F98	R:R:V118	3.93	No	No	0	5	5
91	R:R:F110	R:R:M101	8.71	Yes	No	0	6	5
92	R:R:Q102	R:R:W108	6.57	Yes	Yes	3	5	8
93	R:R:C193	R:R:Q102	3.05	Yes	Yes	3	9	5
94	R:R:D295	R:R:V103	7.3	Yes	No	0	2	4
95	R:R:H107	R:R:L105	6.43	No	No	0	4	5
96	R:R:R190	R:R:V106	5.23	No	No	0	1	4
97	R:R:H107	R:R:P109	9.15	No	No	0	4	4
98	R:R:H107	R:R:R190	21.44	No	No	0	4	1
99	R:R:F110	R:R:W108	15.03	Yes	Yes	0	6	8
100	R:R:C115	R:R:W108	3.92	Yes	Yes	3	9	8
101	R:R:L183	R:R:W108	6.83	No	Yes	3	4	8
102	R:R:C193	R:R:W108	18.28	Yes	Yes	3	9	8
103	R:R:F110	R:R:P109	7.22	Yes	No	0	6	4
104	R:R:F110	R:R:I114	3.77	Yes	No	0	6	6
105	R:R:C115	R:R:L183	3.17	Yes	No	3	9	4
106	R:R:C115	R:R:C193	7.28	Yes	Yes	3	9	9
107	R:R:M119	R:R:V118	3.04	No	No	0	5	5
108	R:R:A181	R:R:M119	3.22	No	No	0	4	5
109	R:R:C193	R:R:M119	6.48	Yes	No	0	9	5
110	R:R:M178	R:R:T120	10.54	No	No	0	5	6
111	R:R:I124	R:R:V121	3.07	Yes	No	9	5	5
112	R:R:N125	R:R:V121	5.91	Yes	No	9	7	5
113	R:R:D122	R:R:Y302	4.6	No	Yes	1	6	7
114	R:R:G123	R:R:I174	5.29	No	No	0	4	7
115	R:R:I124	R:R:N125	2.83	Yes	Yes	9	5	7
116	R:R:I124	R:R:S170	6.19	Yes	No	0	5	7
117	R:R:I124	R:R:L171	4.28	Yes	No	0	5	3
118	R:R:F127	R:R:Q126	4.68	No	Yes	0	6	7
119	R:R:Q126	R:R:W269	12.05	Yes	Yes	1	7	8
120	R:R:F127	R:R:V173	7.87	No	No	0	6	4
121	R:R:F127	R:R:T212	5.19	No	No	0	6	4
122	R:R:T128	R:R:W167	16.98	No	Yes	0	7	9
123	R:R:S170	R:R:T128	6.4	No	No	0	7	7
124	R:R:I130	R:R:P220	3.39	No	Yes	0	8	9
125	R:R:F265	R:R:I130	3.77	Yes	No	1	9	8
126	R:R:I130	R:R:W269	8.22	No	Yes	1	8	8
127	R:R:F131	R:R:V166	3.93	No	No	0	6	6
128	R:R:F131	R:R:L215	3.65	No	No	0	6	4
129	R:R:C132	R:R:V166	3.42	No	No	0	8	6
130	R:R:L133	R:R:N308	9.61	No	Yes	2	9	9
131	R:R:L133	R:R:Y312	7.03	No	Yes	2	9	9
132	R:R:P220	R:R:T134	3.5	Yes	No	0	9	7
133	R:R:I223	R:R:T134	4.56	No	No	0	6	7
134	R:R:I162	R:R:V135	3.07	No	No	0	5	7
135	R:R:M136	R:R:Y312	3.59	No	Yes	0	9	9
136	R:R:I224	R:R:S137	7.74	No	No	0	7	9
137	R:R:C227	R:R:S137	3.44	No	No	0	7	9
138	R:R:S137	R:R:Y228	6.36	No	No	0	9	9
139	R:R:I138	R:R:I223	2.94	No	No	0	6	6
140	R:R:C227	R:R:I138	3.27	No	No	0	7	6
141	R:R:D139	R:R:R154	11.91	No	No	0	8	5
142	R:R:R140	R:R:Y228	7.2	No	No	0	9	9
143	R:R:R140	R:R:Y312	10.29	No	Yes	0	9	9
144	R:R:L142	R:R:Y141	3.52	No	Yes	0	4	8
145	R:R:V145	R:R:Y141	11.36	No	Yes	11	7	8
146	R:R:H146	R:R:Y141	5.44	Yes	Yes	11	5	8
147	R:R:C227	R:R:Y141	8.06	No	Yes	0	7	8
148	R:R:F230	R:R:Y141	7.22	No	Yes	0	4	8
149	R:R:L142	R:R:S150	7.51	No	No	0	4	5
150	R:R:A143	R:R:R154	6.91	No	No	0	8	5
151	R:R:I231	R:R:V144	12.29	No	No	0	9	8
152	R:R:H146	R:R:V145	5.54	Yes	No	11	5	7
153	R:R:K234	R:R:V145	7.59	No	No	0	5	7
154	R:R:H146	R:R:K149	7.86	Yes	No	0	5	4
155	R:R:T158	R:R:W153	9.7	No	No	0	5	3
156	R:R:P156	R:R:R155	2.88	No	No	0	3	6
157	R:R:R155	R:R:R157	4.26	No	No	0	6	4
158	R:R:R155	R:R:T158	6.47	No	No	0	6	5
159	R:R:K160	R:R:M164	2.88	No	No	0	1	4
160	R:R:M164	R:R:T163	3.01	No	No	0	4	7
161	R:R:L171	R:R:M178	2.83	No	No	0	3	5
162	R:R:V173	R:R:Y211	5.05	No	No	10	4	4
163	R:R:L215	R:R:V173	4.47	No	No	10	4	4
164	R:R:I174	R:R:I177	10.3	No	No	0	7	3
165	R:R:L175	R:R:M178	2.83	No	No	0	4	5
166	R:R:I179	R:R:L175	2.85	No	No	0	4	4
167	R:R:I177	R:R:P176	3.39	No	No	0	3	8
168	R:R:F208	R:R:I177	6.28	No	No	0	7	3
169	R:R:I179	R:R:Y180	10.88	No	No	0	4	4
170	R:R:W197	R:R:Y180	3.86	Yes	No	1	5	4
171	R:R:P198	R:R:Y180	12.52	No	No	1	5	4
172	R:R:L183	R:R:S191	6.01	No	No	0	4	5
173	R:R:N186	R:R:W188	5.65	No	No	0	1	2
174	R:R:N186	R:R:R190	3.62	No	No	0	1	1
175	R:R:Q187	R:R:W188	7.67	No	No	0	2	2
176	R:R:S192	R:R:T194	3.2	No	No	5	4	4
177	R:R:I195	R:R:W197	10.57	No	Yes	1	5	5
178	R:R:F208	R:R:I195	3.77	No	No	1	7	5
179	R:R:P198	R:R:W197	6.76	No	Yes	1	5	5
180	R:R:W197	R:R:W204	12.18	Yes	No	0	5	3
181	R:R:W197	R:R:Y205	10.61	Yes	Yes	1	5	4
182	R:R:F208	R:R:W197	7.02	No	Yes	1	7	5
183	R:R:G202	R:R:Y205	2.9	No	Yes	0	2	4
184	R:R:I210	R:R:T206	3.04	No	No	0	5	3
185	R:R:T206	R:R:V280	4.76	No	No	0	3	4
186	R:R:I209	R:R:N276	4.25	Yes	No	0	5	6
187	R:R:I209	R:R:V280	4.61	Yes	No	0	5	4
188	R:R:I210	R:R:I214	2.94	No	No	0	5	4
189	R:R:L215	R:R:Y211	3.52	No	No	10	4	4
190	R:R:T212	R:R:Y273	3.75	No	No	0	4	7
191	R:R:F213	R:R:F217	8.57	No	Yes	1	5	8
192	R:R:F213	R:R:Y273	11.35	No	No	1	5	7
193	R:R:G216	R:R:P220	4.06	No	Yes	0	6	9
194	R:R:F217	R:R:F265	3.22	Yes	Yes	1	8	9
195	R:R:F217	R:R:I266	3.77	Yes	No	1	8	6
196	R:R:F217	R:R:L270	7.31	Yes	No	1	8	5
197	R:R:F217	R:R:Y273	6.19	Yes	No	1	8	7
198	R:R:P220	R:R:V219	3.53	Yes	No	0	9	5
199	R:R:I223	R:R:V219	3.07	No	No	0	6	5
200	R:R:C225	R:R:L221	3.17	No	No	0	5	6
201	R:R:I266	R:R:L221	5.71	No	No	0	6	6
202	R:R:L226	R:R:T222	2.95	No	No	0	5	4
203	R:R:V258	R:R:Y228	12.62	No	No	0	8	9
204	R:R:I233	R:R:L229	4.28	No	No	0	3	4
205	R:R:I232	R:R:T255	3.04	No	No	0	5	7
206	R:R:I232	R:R:V258	4.61	No	No	0	5	8
207	R:R:K234	R:R:S238	6.12	No	No	0	5	5
208	R:R:E251	R:R:K236	6.75	No	No	0	6	4
209	R:R:I240	R:R:R247	3.76	No	No	0	3	4
210	R:R:K252	R:R:R256	3.71	No	No	0	5	6
211	R:R:I260	R:R:L311	4.28	No	No	0	6	8
212	R:R:N304	R:R:V264	2.96	Yes	No	0	9	7
213	R:R:L311	R:R:V264	4.47	No	No	0	8	7
214	R:R:F265	R:R:W269	12.03	Yes	Yes	1	9	8
215	R:R:F265	R:R:N304	3.62	Yes	Yes	1	9	9
216	R:R:I266	R:R:L270	2.85	No	No	1	6	5
217	R:R:C268	R:R:N304	9.45	No	Yes	0	8	9
218	R:R:T301	R:R:W269	14.55	No	Yes	0	7	8
219	R:R:N304	R:R:W269	4.52	Yes	Yes	1	9	8
220	R:R:I274	R:R:L270	5.71	No	No	0	5	5
221	R:R:P271	R:R:V297	3.53	No	No	0	9	7
222	R:R:F272	R:R:N276	18.12	Yes	No	0	6	6
223	R:R:F275	R:R:S278	3.96	Yes	No	0	4	4
224	R:R:F275	R:R:F294	7.5	Yes	No	4	4	4
225	R:R:M282	R:R:S281	3.07	No	No	0	3	4
226	R:R:P286	R:R:S285	3.56	No	No	0	2	2
227	R:R:L290	R:R:T287	4.42	No	No	0	4	1
228	R:R:D295	R:R:K291	4.15	Yes	No	0	2	3
229	R:R:D295	R:R:G292	5.03	Yes	No	0	2	1
230	R:R:F294	R:R:V298	6.55	No	No	0	4	6
231	R:R:F296	R:R:V299	5.24	No	Yes	0	5	5
232	R:R:N308	R:R:Y312	6.98	Yes	Yes	2	9	9
233	R:R:A313	R:R:F319	8.32	No	Yes	0	7	8
234	R:R:F314	R:R:F319	5.36	Yes	Yes	0	7	8
235	R:R:F319	R:R:F323	4.29	Yes	No	0	8	6
236	R:R:K321	R:R:S322	7.65	No	No	0	5	5
237	R:R:E90	R:R:T62	2.82	No	No	0	7	5
238	R:R:L99	R:R:Q102	2.66	No	Yes	0	6	5
239	L:L:F6	R:R:S279	2.64	Yes	No	0	0	4
240	L:L:F11	L:L:S13	2.64	Yes	No	0	0	0
241	R:R:E90	R:R:N61	2.63	No	Yes	0	7	9
242	R:R:F131	R:R:V169	2.62	No	No	0	6	4
243	R:R:F272	R:R:V297	2.62	Yes	No	0	6	7
244	R:R:F272	R:R:V298	2.62	Yes	No	0	6	6
245	R:R:F51	R:R:T47	2.59	No	No	0	5	5
246	R:R:A88	R:R:W167	2.59	No	Yes	0	8	9
247	R:R:F275	R:R:I284	2.51	Yes	No	0	4	1
248	R:R:S201	R:R:W204	2.47	No	No	0	2	3
249	R:R:F230	R:R:L229	2.44	No	No	0	4	4
250	R:R:F296	R:R:L300	2.44	No	No	0	5	7
251	R:R:F323	R:R:L327	2.44	No	No	0	6	7
252	R:R:C115	R:R:G182	1.96	Yes	No	0	9	5
253	R:R:G239	R:R:S244	1.86	No	No	0	5	3
254	R:R:G207	R:R:T206	1.82	No	No	0	4	3
255	R:R:P309	R:R:V64	1.77	No	No	0	9	9
256	R:R:P288	R:R:T287	1.75	No	No	0	3	1
257	R:R:A72	R:R:S322	1.71	No	No	0	5	5
258	R:R:G168	R:R:L171	1.71	No	No	0	4	3
259	R:R:C225	R:R:V262	1.71	No	No	0	5	7
260	R:R:A307	R:R:V264	1.7	No	No	0	6	7
261	R:R:A289	R:R:T287	1.68	No	No	0	1	1
262	R:R:E200	R:R:G199	1.64	No	No	0	4	3
263	R:R:S185	R:R:S191	1.63	No	No	0	2	5
264	R:R:S322	R:R:V67	1.62	No	No	0	5	7
265	R:R:A313	R:R:I82	1.62	No	No	0	7	8
266	R:R:S250	R:R:V235	1.62	No	No	0	5	8
267	R:R:V299	R:R:V53	1.6	Yes	No	6	5	7
268	R:R:V326	R:R:V67	1.6	No	No	0	5	7
269	R:R:V117	R:R:V121	1.6	No	No	0	5	5
270	R:R:V144	R:R:V235	1.6	No	No	0	8	8
271	R:R:V254	R:R:V258	1.6	No	No	0	8	8
272	R:R:S259	R:R:T255	1.6	No	No	0	4	7
273	R:R:T41	R:R:V45	1.59	No	No	0	4	5
274	R:R:A44	R:R:N43	1.56	No	No	0	4	3
275	R:R:A104	R:R:N43	1.56	No	No	0	5	3
276	R:R:A86	R:R:N61	1.56	No	Yes	0	9	9
277	R:R:I49	R:R:V53	1.54	No	No	6	5	7
278	R:R:I49	R:R:V299	1.54	No	Yes	6	5	5
279	R:R:I209	R:R:V277	1.54	Yes	No	0	5	5
280	R:R:I231	R:R:V254	1.54	No	No	0	9	8
281	R:R:H146	R:R:P147	1.53	Yes	No	0	5	8
282	R:R:I65	R:R:T62	1.52	No	No	0	7	5
283	R:R:M257	R:R:V261	1.52	No	No	0	8	8
284	R:R:M293	R:R:V297	1.52	No	No	0	4	7
285	R:R:L46	R:R:S42	1.5	No	No	0	5	4
286	R:R:K75	R:R:T76	1.5	No	No	0	7	7
287	R:R:G239	R:R:R247	1.5	No	No	0	5	4
288	R:R:G243	R:R:R247	1.5	No	No	0	1	4
289	R:R:L46	R:R:V45	1.49	No	No	0	5	5
290	R:R:N318	R:R:S316	1.49	No	No	0	5	8
291	R:R:I240	R:R:K236	1.45	No	No	0	3	4
292	L:L:F11	R:R:P286	1.44	Yes	No	0	0	2
293	R:R:E251	R:R:S250	1.44	No	No	0	6	5
294	R:R:I284	R:R:L290	1.43	No	No	0	1	4
295	R:R:K253	R:R:L315	1.41	No	No	0	7	6
296	R:R:L315	R:R:M257	1.41	No	No	0	6	8
297	R:R:K321	R:R:N318	1.4	No	No	0	5	5
298	L:L:A1	R:R:R184	1.38	No	No	0	0	2
299	R:R:L58	R:R:L94	1.38	No	No	0	6	5
300	R:R:A181	R:R:R116	1.38	No	No	0	4	6
301	R:R:L311	R:R:L315	1.38	No	No	0	8	6
302	R:R:D317	R:R:K320	1.38	No	No	0	5	8
303	R:R:F314	R:R:I310	1.26	Yes	No	0	7	6
304	R:R:I260	R:R:R256	1.25	No	No	0	6	6
305	R:R:K112	R:R:R116	1.24	No	No	0	3	6
306	R:R:F217	R:R:L218	1.22	Yes	No	0	8	4
307	R:R:N196	R:R:R184	1.21	No	No	0	3	2
308	R:R:N325	R:R:Y71	1.16	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F6	8.43	4	4	0
2	L:L:F7	5.934	5	1	0
3	L:L:W8	6.206	5	1	0
4	L:L:K9	5.782	5	1	0
5	L:L:F11	5.195	4	0	0
6	R:R:Y50	4.315	4	0	7
7	R:R:N61	4.7675	4	2	9
8	R:R:Y81	6.274	5	8	7
9	R:R:L85	7.2825	4	2	9
10	R:R:D89	6.79667	6	2	9
11	R:R:F92	10.855	4	0	6
12	R:R:M93	3.245	4	0	6
13	R:R:L96	5.715	4	1	7
14	R:R:Q102	4.8425	4	3	5
15	R:R:W108	10.126	5	3	8
16	R:R:F110	7.59	5	0	6
17	R:R:C115	4.0825	4	3	9
18	R:R:I124	4.0925	4	9	5
19	R:R:N125	5.4125	4	9	7
20	R:R:Q126	6.666	5	1	7
21	R:R:Y141	7.12	5	11	8
22	R:R:H146	5.0925	4	11	5
23	R:R:W167	7.185	4	0	9
24	R:R:C193	8.7725	4	3	9
25	R:R:W197	7.85857	7	1	5
26	R:R:Y205	9.424	5	1	4
27	R:R:I209	3.855	4	0	5
28	R:R:F217	5.04667	6	1	8
29	R:R:P220	3.62	4	0	9
30	R:R:F265	5.66	4	1	9
31	R:R:W269	10.274	5	1	8
32	R:R:F272	6.866	5	1	6
33	R:R:F275	6.975	4	4	4
34	R:R:D295	6.155	4	0	2
35	R:R:V299	3.3575	4	6	5
36	R:R:Y302	11.87	5	1	7
37	R:R:N304	5.1375	4	1	9
38	R:R:N308	8.9125	4	2	9
39	R:R:Y312	6.9725	4	2	9
40	R:R:F314	4.16	4	0	7
41	R:R:F319	6.60167	6	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F7	L:L:W8	25.2489	3.01	Yes	Yes	1	0	0
2	L:L:W8	R:R:F272	20.7571	6.01	Yes	Yes	1	0	6
3	R:R:F272	R:R:V298	52.9505	2.62	Yes	No	0	6	6
4	R:R:F294	R:R:V298	50.8955	6.55	No	No	0	4	6
5	L:L:F6	R:R:F294	34.0321	12.86	Yes	No	4	0	4
6	L:L:F11	L:L:F6	30.3165	4.29	Yes	Yes	0	0	0
7	R:R:F275	R:R:F294	14.7956	7.5	Yes	No	4	4	4
8	L:L:W8	R:R:Q126	34.0385	7.67	Yes	Yes	1	0	7
9	L:L:K9	R:R:Y302	44.9594	8.36	Yes	Yes	1	0	7
10	R:R:L96	R:R:Y302	67.7239	12.89	Yes	Yes	1	7	7
11	R:R:L96	R:R:Y50	58.3522	3.52	Yes	Yes	0	7	7
12	R:R:L99	R:R:Y50	48.7991	4.69	No	Yes	0	6	7
13	R:R:L99	R:R:Q102	47.4089	2.66	No	Yes	0	6	5
14	L:L:F11	R:R:K291	19.6278	12.41	Yes	No	0	0	3
15	R:R:D295	R:R:K291	17.4805	4.15	Yes	No	0	2	3
16	R:R:D295	R:R:L46	10.9718	8.14	Yes	No	0	2	5
17	R:R:M93	R:R:Y302	29.7885	3.59	Yes	Yes	0	6	7
18	R:R:F92	R:R:Q126	59.8823	3.51	Yes	Yes	0	6	7
19	R:R:F92	R:R:S305	71.6303	3.96	Yes	No	0	6	8
20	R:R:D89	R:R:S305	100	8.83	Yes	No	0	9	8
21	R:R:D89	R:R:P309	52.8551	3.22	Yes	No	2	9	9
22	R:R:P309	R:R:V64	52.8169	1.77	No	No	0	9	9
23	R:R:F314	R:R:V64	26.4928	3.93	Yes	No	0	7	9
24	R:R:A313	R:R:V64	25.2267	3.39	No	No	0	7	9
25	R:R:A313	R:R:F319	22.809	8.32	No	Yes	0	7	8
26	R:R:F314	R:R:F319	22.8567	5.36	Yes	Yes	0	7	8
27	R:R:F319	R:R:V67	23.178	9.18	Yes	No	0	8	7
28	R:R:F319	R:R:K73	12.6992	8.69	Yes	No	7	8	5
29	R:R:K73	R:R:N79	10.3674	20.98	No	No	0	5	8
30	R:R:D89	R:R:L85	20.3149	9.5	Yes	Yes	2	9	9
31	R:R:L85	R:R:M136	19.5228	5.65	Yes	No	0	9	9
32	R:R:M136	R:R:Y81	20.7508	4.79	No	Yes	0	9	7
33	R:R:F92	R:R:N125	18.8675	6.04	Yes	Yes	0	6	7
34	R:R:I124	R:R:N125	14.3502	2.83	Yes	Yes	9	5	7
35	R:R:D89	R:R:N308	33.9971	8.08	Yes	Yes	2	9	9
36	R:R:Q102	R:R:W108	28.7069	6.57	Yes	Yes	3	5	8
37	R:R:F110	R:R:W108	20.0827	15.03	Yes	Yes	0	6	8
38	R:R:C193	R:R:Q102	11.8562	3.05	Yes	Yes	3	9	5
39	R:R:F110	R:R:P109	12.6197	7.22	Yes	No	0	6	4
40	R:R:H107	R:R:P109	11.0641	9.15	No	No	0	4	4
41	R:R:F127	R:R:Q126	10.676	4.68	No	Yes	0	6	7
42	R:R:Q126	R:R:W269	48.4937	12.05	Yes	Yes	1	7	8
43	R:R:I130	R:R:W269	30.4979	8.22	No	Yes	1	8	8
44	R:R:I130	R:R:P220	35.0215	3.39	No	Yes	0	8	9
45	R:R:N308	R:R:Y312	31.9994	6.98	Yes	Yes	2	9	9
46	R:R:P220	R:R:T134	16.628	3.5	Yes	No	0	9	7
47	R:R:I223	R:R:T134	15.7341	4.56	No	No	0	6	7
48	R:R:P220	R:R:V219	16.628	3.53	Yes	No	0	9	5
49	R:R:I223	R:R:V219	15.7341	3.07	No	No	0	6	5
50	R:R:R140	R:R:Y312	33.7045	10.29	No	Yes	0	9	9
51	R:R:R140	R:R:Y228	32.6547	7.2	No	No	0	9	9
52	R:R:S137	R:R:Y228	16.9811	6.36	No	No	0	9	9
53	R:R:I138	R:R:I223	29.6962	2.94	No	No	0	6	6
54	R:R:C227	R:R:I138	28.2901	3.27	No	No	0	7	6
55	R:R:C227	R:R:S137	16.4085	3.44	No	No	0	7	9
56	R:R:C227	R:R:Y141	28.306	8.06	No	Yes	0	7	8
57	R:R:V258	R:R:Y228	24.8704	12.62	No	No	0	8	9
58	R:R:V254	R:R:V258	18.7498	1.6	No	No	0	8	8
59	R:R:I231	R:R:V254	17.3501	1.54	No	No	0	9	8
60	R:R:I231	R:R:V144	15.804	12.29	No	No	0	9	8
61	R:R:V144	R:R:V235	14.2739	1.6	No	No	0	8	8
62	R:R:S250	R:R:V235	12.7119	1.62	No	No	0	5	8
63	R:R:E251	R:R:S250	11.15	1.44	No	No	0	6	5
64	R:R:N304	R:R:W269	15.2378	4.52	Yes	Yes	1	9	8
65	R:R:N304	R:R:V264	15.3746	2.96	Yes	No	0	9	7
66	R:R:L311	R:R:V264	12.2793	4.47	No	No	0	8	7
67	R:R:F275	R:R:I284	10.7969	2.51	Yes	No	0	4	1
68	R:R:S322	R:R:V67	12.9442	1.62	No	No	0	5	7
69	L:L:F7	R:R:W197	10.501	4.01	Yes	Yes	1	0	5
70	L:L:K9	R:R:F272	42.8312	4.96	Yes	Yes	1	0	6
71	L:L:K9	R:R:Q126	28.4205	5.42	Yes	Yes	1	0	7
72	R:R:F92	R:R:Y302	41.9278	29.91	Yes	Yes	0	6	7
73	R:R:M93	R:R:S305	31.3281	3.07	Yes	No	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G2	R:R:Y205	4.35	0	No	Yes	0	4	0	1
L:L:K4	R:R:Y205	17.91	0	No	Yes	0	4	0	1
L:L:N5	R:R:P286	3.26	0	No	No	0	2	0	1
L:L:F6	R:R:F275	13.93	4	Yes	Yes	0	4	0	1
L:L:F6	R:R:F294	12.86	4	Yes	No	0	4	0	1
L:L:F7	R:R:I195	6.28	1	Yes	No	0	5	0	1
L:L:F7	R:R:W197	4.01	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:Y205	11.35	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:I209	5.02	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:Q126	7.67	1	Yes	Yes	0	7	0	1
L:L:W8	R:R:T212	9.7	1	Yes	No	0	4	0	1
L:L:W8	R:R:F272	6.01	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:D122	5.53	1	Yes	No	0	6	0	1
L:L:K9	R:R:Q126	5.42	1	Yes	Yes	0	7	0	1
L:L:K9	R:R:F272	4.96	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:Y302	8.36	1	Yes	Yes	0	7	0	1
L:L:T10	R:R:Q102	7.09	0	No	Yes	0	5	0	1
L:L:T10	R:R:T194	7.85	0	No	No	0	4	0	1
L:L:F11	R:R:K291	12.41	0	Yes	No	0	3	0	1
L:L:T12	R:R:S192	6.4	5	No	No	0	4	0	1
L:L:T12	R:R:T194	4.71	5	No	No	0	4	0	1
R:R:F92	R:R:Q126	3.51	0	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	29.91	0	Yes	Yes	6	7	2	1
R:R:M93	R:R:Y302	3.59	0	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	12.89	1	Yes	Yes	7	7	2	1
R:R:Q102	R:R:W108	6.57	3	Yes	Yes	5	8	1	2
R:R:C193	R:R:Q102	3.05	3	Yes	Yes	9	5	2	1
R:R:C193	R:R:W108	18.28	3	Yes	Yes	9	8	2	2
R:R:D122	R:R:Y302	4.6	1	No	Yes	6	7	1	1
R:R:F127	R:R:Q126	4.68	0	No	Yes	6	7	2	1
R:R:Q126	R:R:W269	12.05	1	Yes	Yes	7	8	1	2
R:R:F127	R:R:T212	5.19	0	No	No	6	4	2	1
R:R:W197	R:R:Y180	3.86	1	Yes	No	5	4	1	2
R:R:P198	R:R:Y180	12.52	1	No	No	5	4	2	2
R:R:S192	R:R:T194	3.2	5	No	No	4	4	1	1
R:R:I195	R:R:W197	10.57	1	No	Yes	5	5	1	1
R:R:F208	R:R:I195	3.77	1	No	No	7	5	2	1
R:R:P198	R:R:W197	6.76	1	No	Yes	5	5	2	1
R:R:W197	R:R:W204	12.18	1	Yes	No	5	3	1	2
R:R:W197	R:R:Y205	10.61	1	Yes	Yes	5	4	1	1
R:R:F208	R:R:W197	7.02	1	No	Yes	7	5	2	1
R:R:G202	R:R:Y205	2.9	0	No	Yes	2	4	2	1
R:R:I209	R:R:N276	4.25	0	Yes	No	5	6	1	2
R:R:I209	R:R:V280	4.61	0	Yes	No	5	4	1	2
R:R:T212	R:R:Y273	3.75	0	No	No	4	7	1	2
R:R:F272	R:R:N276	18.12	1	Yes	No	6	6	1	2
R:R:F275	R:R:S278	3.96	4	Yes	No	4	4	1	2
R:R:F275	R:R:F294	7.5	4	Yes	No	4	4	1	1
R:R:P286	R:R:S285	3.56	0	No	No	2	2	1	2
R:R:D295	R:R:K291	4.15	0	Yes	No	2	3	2	1
R:R:F294	R:R:V298	6.55	4	No	No	4	6	1	2
R:R:L99	R:R:Q102	2.66	0	No	Yes	6	5	2	1
L:L:F6	R:R:S279	2.64	4	Yes	No	0	4	0	1
R:R:F272	R:R:V297	2.62	1	Yes	No	6	7	1	2
R:R:F272	R:R:V298	2.62	1	Yes	No	6	6	1	2
R:R:F275	R:R:I284	2.51	4	Yes	No	4	1	1	2
R:R:I209	R:R:V277	1.54	0	Yes	No	5	5	1	2
L:L:F11	R:R:P286	1.44	0	Yes	No	0	2	0	1
L:L:A1	R:R:R184	1.38	0	No	No	0	2	0	1
R:R:N196	R:R:R184	1.21	0	No	No	3	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WIC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	277
Number of Links	308
Number of Hubs	41
Number of Links mediated by Hubs	146
Number of Communities	11
Number of Nodes involved in Communities	62
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	68198
Length Of Smallest Path	3
Average Path Length	13.7805
Length of Longest Path	32
Minimum Path Strength	1.295
Average Path Strength	6.15042
Maximum Path Strength	21.4
Minimum Path Correlation	0.7
Average Path Correlation	0.920595
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	44.0405
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.9387
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to acid chemical • response to stimulus • response to chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • biological regulation • regulation of biological quality • somatostatin signaling pathway • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • response to endogenous stimulus • hormone-mediated signaling pathway • cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • somatostatin receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular response to hormone stimulus • cell-cell signaling • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • response to osmotic stress • hyperosmotic response • response to stress • response to abiotic stimulus • cell surface receptor signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to lipid • response to steroid hormone • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient levels • response to nutrient • response to pH • response to acidic pH • multicellular organismal process • digestion • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • cytosol • GABA-ergic synapse • synapse • cell junction • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • binding • neuropeptide binding • peptide binding • protein binding • PDZ domain binding • protein domain specific binding • multicellular organismal process • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cerebellum development • metencephalon development • hindbrain development • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • plasma membrane • membrane • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • dendrite • dendritic tree • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7WIC_nogp_Chain_R L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

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Download 7WIC_nogp.zip

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