psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	13.45	Yes	No	1	0	0
2	L:L:?1	L:L:C7	4.03	Yes	No	1	0	0
3	L:L:?1	L:L:?8	19.78	Yes	Yes	1	0	0
4	L:L:?1	R:R:W188	3.86	Yes	Yes	1	0	2
5	L:L:?1	R:R:P286	8.35	Yes	No	0	0	2
6	L:L:C2	L:L:C7	7.28	No	No	1	0	0
7	L:L:C2	R:R:F294	8.38	No	Yes	1	0	4
8	L:L:?4	L:L:F3	7.73	Yes	Yes	1	0	0
9	L:L:F3	R:R:W197	3.01	Yes	Yes	1	0	5
10	L:L:F3	R:R:Y205	14.44	Yes	No	1	0	4
11	L:L:F3	R:R:I209	5.02	Yes	Yes	0	0	5
12	L:L:?4	L:L:K5	15.67	Yes	Yes	1	0	0
13	L:L:?4	R:R:I177	3.4	Yes	No	0	0	3
14	L:L:?4	R:R:T212	3.51	Yes	No	0	0	4
15	L:L:?4	R:R:F272	4.83	Yes	Yes	1	0	6
16	L:L:?4	R:R:N276	9.81	Yes	Yes	1	0	6
17	L:L:?4	R:R:F294	2.9	Yes	Yes	1	0	4
18	L:L:K5	R:R:D122	5.53	Yes	Yes	1	0	6
19	L:L:K5	R:R:Q126	2.71	Yes	Yes	0	0	7
20	L:L:K5	R:R:Y302	3.58	Yes	Yes	1	0	7
21	L:L:T6	R:R:Q102	11.34	No	No	1	0	5
22	L:L:T6	R:R:S192	3.2	No	Yes	1	0	4
23	L:L:T6	R:R:T194	3.14	No	No	1	0	4
24	L:L:C7	R:R:F294	6.98	No	Yes	1	0	4
25	L:L:?8	R:R:R184	3.15	Yes	Yes	0	0	2
26	L:L:?8	R:R:N186	10.69	Yes	No	1	0	1
27	L:L:?8	R:R:W188	5.91	Yes	Yes	1	0	2
28	L:L:?8	R:R:S192	3.9	Yes	Yes	1	0	4
29	R:R:N43	R:R:T47	2.92	No	No	0	3	5
30	R:R:L46	R:R:Y50	5.86	No	Yes	0	5	7
31	R:R:D295	R:R:L46	5.43	No	No	0	2	5
32	R:R:F51	R:R:T47	2.59	No	No	0	5	5
33	R:R:A104	R:R:T47	3.36	No	No	0	5	5
34	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
35	R:R:V103	R:R:Y50	2.52	No	Yes	0	4	7
36	R:R:V298	R:R:Y50	2.52	No	Yes	0	6	7
37	R:R:V299	R:R:Y50	8.83	No	Yes	0	5	7
38	R:R:F51	R:R:P97	2.89	No	No	0	5	8
39	R:R:A100	R:R:F51	4.16	No	No	0	6	5
40	R:R:C54	R:R:L96	4.76	No	Yes	0	6	7
41	R:R:C54	R:R:P97	3.77	No	No	0	6	8
42	R:R:G57	R:R:M93	3.49	No	Yes	0	8	6
43	R:R:L58	R:R:L94	2.77	No	No	0	6	5
44	R:R:D89	R:R:N61	6.73	Yes	No	0	9	9
45	R:R:N61	R:R:P309	6.52	No	No	0	9	9
46	R:R:E90	R:R:T62	5.64	No	No	0	7	5
47	R:R:F314	R:R:L63	2.44	Yes	No	0	7	6
48	R:R:F323	R:R:L63	2.44	No	No	0	6	6
49	R:R:P309	R:R:V64	3.53	No	Yes	0	9	9
50	R:R:A313	R:R:V64	3.39	No	Yes	2	7	9
51	R:R:F314	R:R:V64	3.93	Yes	Yes	2	7	9
52	R:R:F319	R:R:V64	5.24	Yes	Yes	2	8	9
53	R:R:I65	R:R:L69	2.85	Yes	No	0	7	3
54	R:R:I65	R:R:L83	2.85	Yes	No	0	7	6
55	R:R:A86	R:R:I65	3.25	No	Yes	0	9	7
56	R:R:R70	R:R:Y66	18.52	No	No	0	4	3
57	R:R:V326	R:R:Y66	2.52	No	No	0	5	3
58	R:R:F319	R:R:V67	9.18	Yes	No	0	8	7
59	R:R:I68	R:R:N79	2.83	No	No	0	7	8
60	R:R:F319	R:R:I68	6.28	Yes	No	0	8	7
61	R:R:S322	R:R:Y71	6.36	No	No	0	5	6
62	R:R:N325	R:R:Y71	24.42	No	No	4	4	6
63	R:R:V326	R:R:Y71	6.31	No	No	4	5	6
64	R:R:I80	R:R:M74	2.92	Yes	No	0	5	7
65	R:R:T76	R:R:T78	3.14	No	No	0	7	8
66	R:R:I77	R:R:Y81	6.04	No	No	0	4	7
67	R:R:I77	R:R:R154	3.76	No	No	0	4	5
68	R:R:I82	R:R:T78	3.04	No	No	0	8	8
69	R:R:A159	R:R:I80	3.25	No	Yes	0	7	5
70	R:R:D139	R:R:Y81	11.49	No	No	0	8	7
71	R:R:A159	R:R:Y81	4	No	No	0	7	7
72	R:R:I87	R:R:L83	2.85	No	No	0	7	6
73	R:R:N84	R:R:T163	16.08	No	No	0	9	7
74	R:R:D89	R:R:L85	4.07	Yes	No	3	9	9
75	R:R:C132	R:R:L85	6.35	No	No	0	8	9
76	R:R:L85	R:R:N308	5.49	No	No	3	9	9
77	R:R:D89	R:R:S129	5.89	Yes	No	0	9	9
78	R:R:D89	R:R:S305	7.36	Yes	No	0	9	8
79	R:R:D89	R:R:N308	6.73	Yes	No	3	9	9
80	R:R:L91	R:R:N125	6.87	No	Yes	0	7	7
81	R:R:D122	R:R:F92	8.36	Yes	Yes	1	6	6
82	R:R:F92	R:R:N125	4.83	Yes	Yes	0	6	7
83	R:R:F92	R:R:Q126	5.86	Yes	Yes	0	6	7
84	R:R:F92	R:R:Y302	15.47	Yes	Yes	1	6	7
85	R:R:F92	R:R:S305	3.96	Yes	No	0	6	8
86	R:R:L96	R:R:M93	7.07	Yes	Yes	0	7	6
87	R:R:M93	R:R:S305	3.07	Yes	No	0	6	8
88	R:R:C306	R:R:M93	3.24	No	Yes	0	8	6
89	R:R:L96	R:R:Y302	11.72	Yes	Yes	0	7	7
90	R:R:F98	R:R:W108	3.01	No	Yes	1	5	8
91	R:R:F98	R:R:I114	3.77	No	Yes	1	5	6
92	R:R:M101	R:R:P109	5.03	No	No	0	5	4
93	R:R:Q102	R:R:W108	7.67	No	Yes	1	5	8
94	R:R:Q102	R:R:S192	4.33	No	Yes	1	5	4
95	R:R:D295	R:R:V103	5.84	No	No	0	2	4
96	R:R:L105	R:R:P109	4.93	No	No	0	5	4
97	R:R:V106	R:R:W188	2.45	No	Yes	0	4	2
98	R:R:R190	R:R:V106	11.77	Yes	No	0	1	4
99	R:R:H107	R:R:R190	14.67	No	Yes	0	4	1
100	R:R:P109	R:R:W108	2.7	No	Yes	0	4	8
101	R:R:F110	R:R:W108	3.01	No	Yes	1	6	8
102	R:R:I114	R:R:W108	5.87	Yes	Yes	1	6	8
103	R:R:C115	R:R:W108	2.61	No	Yes	1	9	8
104	R:R:L183	R:R:W108	3.42	No	Yes	0	4	8
105	R:R:C193	R:R:W108	5.22	No	Yes	1	9	8
106	R:R:F110	R:R:I114	16.33	No	Yes	1	6	6
107	R:R:K112	R:R:R116	3.71	No	No	0	3	6
108	R:R:I114	R:R:V117	3.07	Yes	No	0	6	5
109	R:R:C115	R:R:C193	7.28	No	No	1	9	9
110	R:R:C193	R:R:M119	4.86	No	No	0	9	5
111	R:R:M178	R:R:T120	4.52	No	No	0	5	6
112	R:R:N125	R:R:V121	2.96	Yes	No	0	7	5
113	R:R:D122	R:R:Y302	8.05	Yes	Yes	1	6	7
114	R:R:I124	R:R:N125	5.66	No	Yes	0	5	7
115	R:R:I124	R:R:S170	4.64	No	No	0	5	7
116	R:R:F127	R:R:Q126	4.68	No	Yes	0	6	7
117	R:R:Q126	R:R:W269	9.86	Yes	Yes	0	7	8
118	R:R:F127	R:R:F131	3.22	No	No	0	6	6
119	R:R:F127	R:R:S170	2.64	No	No	0	6	7
120	R:R:T128	R:R:W167	12.13	No	No	0	7	9
121	R:R:S170	R:R:T128	3.2	No	No	0	7	7
122	R:R:F131	R:R:I130	3.77	No	No	0	6	8
123	R:R:I130	R:R:P220	3.39	No	No	0	8	9
124	R:R:P220	R:R:T134	3.5	No	No	0	9	7
125	R:R:I223	R:R:T134	4.56	No	No	0	6	7
126	R:R:M136	R:R:Y312	4.79	No	No	0	9	9
127	R:R:I224	R:R:S137	6.19	No	No	0	7	9
128	R:R:C227	R:R:S137	3.44	No	No	0	7	9
129	R:R:S137	R:R:Y228	3.82	No	Yes	0	9	9
130	R:R:I138	R:R:I223	2.94	No	No	0	6	6
131	R:R:D139	R:R:R154	7.15	No	No	0	8	5
132	R:R:R140	R:R:Y312	6.17	No	No	0	9	9
133	R:R:V145	R:R:Y141	12.62	No	Yes	0	7	8
134	R:R:C227	R:R:Y141	6.72	No	Yes	0	7	8
135	R:R:F230	R:R:Y141	7.22	No	Yes	0	4	8
136	R:R:L142	R:R:S150	4.5	No	No	0	4	5
137	R:R:A143	R:R:R154	5.53	No	No	0	8	5
138	R:R:H146	R:R:V145	4.15	Yes	No	0	5	7
139	R:R:H146	R:R:S150	4.18	Yes	No	0	5	5
140	R:R:P156	R:R:R155	7.21	No	No	0	3	6
141	R:R:R155	R:R:R157	5.33	No	No	0	6	4
142	R:R:R157	R:R:T158	2.59	No	No	0	4	5
143	R:R:M161	R:R:R157	13.65	No	No	0	1	4
144	R:R:I162	R:R:T158	3.04	No	No	0	5	5
145	R:R:T163	R:R:W167	2.43	No	No	0	7	9
146	R:R:V173	R:R:Y211	2.52	No	No	0	4	4
147	R:R:F208	R:R:I177	3.77	No	No	0	7	3
148	R:R:I179	R:R:Y180	12.09	No	No	0	4	4
149	R:R:P198	R:R:Y180	9.74	No	No	0	5	4
150	R:R:R184	R:R:T194	5.17	Yes	No	0	2	4
151	R:R:N196	R:R:R184	7.23	No	Yes	0	3	2
152	R:R:E200	R:R:R184	4.65	No	Yes	0	4	2
153	R:R:N186	R:R:W188	3.39	No	Yes	1	1	2
154	R:R:N186	R:R:R190	3.62	No	Yes	0	1	1
155	R:R:Q187	R:R:W188	7.67	No	Yes	0	2	2
156	R:R:K291	R:R:W188	3.48	No	Yes	0	3	2
157	R:R:S192	R:R:T194	6.4	Yes	No	1	4	4
158	R:R:I195	R:R:W197	4.7	No	Yes	0	5	5
159	R:R:P198	R:R:W197	2.7	No	Yes	1	5	5
160	R:R:W197	R:R:W204	6.56	Yes	No	1	5	3
161	R:R:W197	R:R:Y205	12.54	Yes	No	1	5	4
162	R:R:F208	R:R:W197	11.02	No	Yes	0	7	5
163	R:R:P198	R:R:W204	6.76	No	No	1	5	3
164	R:R:G202	R:R:S201	3.71	No	No	0	2	2
165	R:R:G202	R:R:Y205	2.9	No	No	0	2	4
166	R:R:F208	R:R:T212	7.78	No	No	0	7	4
167	R:R:I209	R:R:N276	2.83	Yes	Yes	0	5	6
168	R:R:I209	R:R:V280	3.07	Yes	No	0	5	4
169	R:R:I210	R:R:I214	2.94	No	No	0	5	4
170	R:R:L215	R:R:Y211	4.69	No	No	0	4	4
171	R:R:F213	R:R:F217	5.36	No	Yes	1	5	8
172	R:R:F213	R:R:L218	6.09	No	No	0	5	4
173	R:R:F213	R:R:Y273	7.22	No	Yes	1	5	7
174	R:R:F217	R:R:F265	4.29	Yes	No	0	8	9
175	R:R:F217	R:R:L270	2.44	Yes	No	0	8	5
176	R:R:F217	R:R:Y273	3.09	Yes	Yes	1	8	7
177	R:R:P220	R:R:V219	3.53	No	No	0	9	5
178	R:R:T222	R:R:V219	3.17	No	No	0	4	5
179	R:R:I223	R:R:V219	3.07	No	No	0	6	5
180	R:R:C225	R:R:L221	3.17	No	No	0	5	6
181	R:R:I266	R:R:L221	5.71	No	No	0	6	6
182	R:R:V258	R:R:Y228	7.57	No	Yes	0	8	9
183	R:R:V261	R:R:Y228	2.52	No	Yes	0	8	9
184	R:R:V262	R:R:Y228	2.52	No	Yes	0	7	9
185	R:R:I233	R:R:L229	4.28	No	No	0	3	4
186	R:R:L251	R:R:V235	4.47	No	No	0	6	8
187	R:R:L241	R:R:V238	10.43	No	No	0	1	5
188	R:R:L240	R:R:L241	2.77	No	No	0	3	1
189	R:R:K247	R:R:S242	9.18	No	No	0	4	3
190	R:R:D248	R:R:K247	15.21	No	No	0	3	4
191	R:R:K247	R:R:L251	9.87	No	No	0	4	6
192	R:R:R252	R:R:R256	7.46	No	No	0	5	6
193	R:R:F265	R:R:W269	7.02	No	Yes	0	9	8
194	R:R:I266	R:R:L270	2.85	No	No	0	6	5
195	R:R:C268	R:R:W269	2.61	No	Yes	1	8	8
196	R:R:C268	R:R:N304	9.45	No	No	1	8	9
197	R:R:W269	R:R:Y273	4.82	Yes	Yes	1	8	7
198	R:R:T301	R:R:W269	6.06	No	Yes	0	7	8
199	R:R:N304	R:R:W269	7.91	No	Yes	1	9	8
200	R:R:L270	R:R:P271	3.28	No	No	0	5	9
201	R:R:F272	R:R:Y273	5.16	Yes	Yes	1	6	7
202	R:R:F272	R:R:N276	8.46	Yes	Yes	1	6	6
203	R:R:F272	R:R:T301	5.19	Yes	No	0	6	7
204	R:R:F275	R:R:S279	7.93	No	No	0	4	4
205	R:R:F275	R:R:F294	8.57	No	Yes	0	4	4
206	R:R:F294	R:R:N276	3.62	Yes	Yes	1	4	6
207	R:R:I284	R:R:M282	4.37	No	No	0	1	3
208	R:R:P288	R:R:T287	8.74	No	No	0	3	1
209	R:R:L290	R:R:T287	4.42	No	No	0	4	1
210	R:R:D295	R:R:K291	4.15	No	No	0	2	3
211	R:R:F294	R:R:V298	3.93	Yes	No	0	4	6
212	R:R:N308	R:R:Y312	4.65	No	No	0	9	9
213	R:R:F314	R:R:I310	3.77	Yes	No	0	7	6
214	R:R:A313	R:R:F314	2.77	No	Yes	2	7	7
215	R:R:A313	R:R:F319	4.16	No	Yes	2	7	8
216	R:R:F314	R:R:F319	3.22	Yes	Yes	2	7	8
217	R:R:N318	R:R:S316	2.98	No	No	0	5	8
218	R:R:D317	R:R:K321	2.77	No	No	0	5	5
219	R:R:K320	R:R:Q324	2.71	No	No	0	8	4
220	R:R:F323	R:R:L327	13.4	No	No	0	6	7
221	R:R:N325	R:R:V326	4.43	No	No	4	4	5
222	R:R:I231	R:R:Y141	2.42	No	Yes	0	9	8
223	R:R:R140	R:R:Y228	2.06	No	Yes	0	9	9
224	R:R:G95	R:R:P97	2.03	No	No	0	6	8
225	R:R:C59	R:R:G60	1.96	No	No	0	5	8
226	R:R:C115	R:R:G182	1.96	No	No	0	9	5
227	R:R:A181	R:R:G182	1.95	No	No	0	4	5
228	R:R:G243	R:R:S242	1.86	No	No	0	1	3
229	R:R:G207	R:R:T206	1.82	No	No	0	4	3
230	R:R:P286	R:R:S285	1.78	No	No	0	2	2
231	R:R:P271	R:R:V297	1.77	No	No	0	9	7
232	R:R:G111	R:R:I114	1.76	No	Yes	0	7	6
233	R:R:G123	R:R:I174	1.76	No	No	0	4	7
234	R:R:A72	R:R:S322	1.71	No	No	0	5	5
235	R:R:A88	R:R:S129	1.71	No	No	0	8	9
236	R:R:G168	R:R:L171	1.71	No	No	0	4	3
237	R:R:G168	R:R:L172	1.71	No	No	0	4	3
238	R:R:A203	R:R:S201	1.71	No	No	0	1	2
239	R:R:C268	R:R:V264	1.71	No	No	0	8	7
240	R:R:A86	R:R:V64	1.7	No	Yes	0	9	9
241	R:R:I80	R:R:P156	1.69	Yes	No	0	5	3
242	R:R:I148	R:R:P147	1.69	No	No	0	5	8
243	R:R:D122	R:R:G123	1.68	Yes	No	0	6	4
244	R:R:A289	R:R:T287	1.68	No	No	0	1	1
245	R:R:L175	R:R:P176	1.64	No	No	0	4	8
246	R:R:E200	R:R:G199	1.64	No	No	0	4	3
247	R:R:S278	R:R:S279	1.63	No	No	0	4	4
248	R:R:S322	R:R:V67	1.62	No	No	0	5	7
249	R:R:V117	R:R:V118	1.6	No	No	0	5	5
250	R:R:V144	R:R:V235	1.6	No	No	0	8	8
251	R:R:V169	R:R:V173	1.6	No	No	0	4	4
252	R:R:V254	R:R:V258	1.6	No	No	5	8	8
253	R:R:S259	R:R:T255	1.6	No	No	0	4	7
254	R:R:C54	R:R:L58	1.59	No	No	0	6	6
255	R:R:T206	R:R:V280	1.59	No	No	0	3	4
256	R:R:A44	R:R:N43	1.56	No	No	0	4	3
257	R:R:I284	R:R:S279	1.55	No	No	0	1	4
258	R:R:I49	R:R:V53	1.54	No	No	0	5	7
259	R:R:I56	R:R:V52	1.54	No	No	0	4	5
260	R:R:I82	R:R:V64	1.54	No	Yes	0	8	9
261	R:R:I162	R:R:V135	1.54	No	No	0	5	7
262	R:R:I162	R:R:V166	1.54	No	No	0	5	6
263	R:R:I209	R:R:V277	1.54	Yes	No	0	5	5
264	R:R:I231	R:R:V235	1.54	No	No	0	9	8
265	R:R:I232	R:R:V254	1.54	No	No	5	5	8
266	R:R:I232	R:R:V258	1.54	No	No	5	5	8
267	R:R:I260	R:R:V264	1.54	No	No	0	6	7
268	R:R:H146	R:R:P147	1.53	Yes	No	0	5	8
269	R:R:I174	R:R:T120	1.52	No	No	0	7	6
270	R:R:I177	R:R:T120	1.52	No	No	0	3	6
271	R:R:K234	R:R:V145	1.52	No	No	0	5	7
272	R:R:I210	R:R:T206	1.52	No	No	0	5	3
273	R:R:I232	R:R:T255	1.52	No	No	0	5	7
274	R:R:M257	R:R:V261	1.52	No	No	0	8	8
275	R:R:K75	R:R:T76	1.5	No	No	0	7	7
276	R:R:L183	R:R:S191	1.5	No	No	0	4	5
277	R:R:G189	R:R:R190	1.5	No	Yes	0	6	1
278	R:R:L96	R:R:V53	1.49	Yes	No	0	7	7
279	R:R:L311	R:R:V261	1.49	No	No	0	8	8
280	R:R:I55	R:R:I56	1.47	No	No	0	4	4
281	R:R:L133	R:R:T134	1.47	No	No	0	9	7
282	R:R:G216	R:R:Y273	1.45	No	Yes	0	6	7
283	R:R:K73	R:R:K75	1.44	No	No	0	5	7
284	R:R:K149	R:R:K152	1.44	No	No	0	4	4
285	R:R:K253	R:R:M257	1.44	No	No	0	7	8
286	R:R:I124	R:R:L171	1.43	No	No	0	5	3
287	R:R:I174	R:R:L171	1.43	No	No	0	7	3
288	R:R:I179	R:R:L175	1.43	No	No	0	4	4
289	R:R:I214	R:R:L215	1.43	No	No	0	4	4
290	R:R:I284	R:R:L290	1.43	No	No	0	1	4
291	R:R:I80	R:R:N84	1.42	Yes	No	0	5	9
292	R:R:E90	R:R:I65	1.37	No	Yes	0	7	7
293	R:R:F319	R:R:S316	1.32	Yes	No	0	8	8
294	R:R:H146	R:R:K149	1.31	Yes	No	0	5	4
295	R:R:E246	R:R:N250	1.31	No	No	0	3	5
296	R:R:F296	R:R:V299	1.31	No	No	0	5	5
297	R:R:F230	R:R:I233	1.26	No	No	0	4	3
298	R:R:F296	R:R:L300	1.22	No	No	0	5	7
299	R:R:L240	R:R:R239	1.21	No	No	0	3	5
300	R:R:L99	R:R:Y302	1.17	No	Yes	0	6	7
301	R:R:F323	R:R:Q324	1.17	No	No	0	6	4
302	R:R:K152	R:R:W153	1.16	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.894	5	1	0
2	L:L:F3	7.55	4	1	0
3	L:L:?4	6.83571	7	1	0
4	L:L:K5	6.8725	4	1	0
5	L:L:?8	8.686	5	1	0
6	R:R:Y50	4.746	5	0	7
7	R:R:V64	3.22167	6	2	9
8	R:R:I65	2.58	4	0	7
9	R:R:I80	2.32	4	0	5
10	R:R:D89	6.156	5	3	9
11	R:R:F92	7.696	5	1	6
12	R:R:M93	4.2175	4	0	6
13	R:R:L96	6.26	4	0	7
14	R:R:W108	4.18875	8	1	8
15	R:R:I114	6.16	5	1	6
16	R:R:D122	5.905	4	1	6
17	R:R:N125	5.08	4	0	7
18	R:R:Q126	5.7775	4	0	7
19	R:R:Y141	7.245	4	0	8
20	R:R:H146	2.7925	4	0	5
21	R:R:R184	5.05	4	0	2
22	R:R:W188	4.46	6	1	2
23	R:R:R190	7.89	4	0	1
24	R:R:S192	4.4575	4	1	4
25	R:R:W197	6.755	6	1	5
26	R:R:I209	3.115	4	0	5
27	R:R:F217	3.795	4	1	8
28	R:R:Y228	3.698	5	0	9
29	R:R:W269	6.38	6	1	8
30	R:R:F272	5.91	4	1	6
31	R:R:Y273	4.348	5	1	7
32	R:R:N276	6.18	4	1	6
33	R:R:F294	5.73	6	1	4
34	R:R:Y302	7.998	5	1	7
35	R:R:F314	3.226	5	2	7
36	R:R:F319	4.9	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	39.6596	13.45	Yes	No	1	0	0
2	L:L:C2	R:R:F294	40.4607	8.38	No	Yes	1	0	4
3	L:L:?1	L:L:C7	39.6887	4.03	Yes	No	1	0	0
4	L:L:C7	R:R:F294	40.3964	6.98	No	Yes	1	0	4
5	L:L:?4	R:R:F294	84.6488	2.9	Yes	Yes	1	0	4
6	L:L:?4	L:L:F3	19.8111	7.73	Yes	Yes	1	0	0
7	R:R:I209	R:R:N276	10.6838	2.83	Yes	Yes	0	5	6
8	L:L:?4	L:L:K5	100	15.67	Yes	Yes	1	0	0
9	L:L:K5	R:R:D122	28.3345	5.53	Yes	Yes	1	0	6
10	L:L:K5	R:R:Q126	42.8826	2.71	Yes	Yes	0	0	7
11	L:L:K5	R:R:Y302	32.9293	3.58	Yes	Yes	1	0	7
12	L:L:?1	L:L:?8	55.0877	19.78	Yes	Yes	1	0	0
13	L:L:?8	R:R:S192	39.2383	3.9	Yes	Yes	1	0	4
14	R:R:Q102	R:R:S192	33.8425	4.33	No	Yes	1	5	4
15	L:L:?1	R:R:W188	19.1719	3.86	Yes	Yes	1	0	2
16	R:R:F294	R:R:V298	10.3227	3.93	Yes	No	0	4	6
17	R:R:D122	R:R:F92	28.623	8.36	Yes	Yes	1	6	6
18	R:R:F92	R:R:S305	95.3575	3.96	Yes	No	0	6	8
19	R:R:D89	R:R:S305	97.9558	7.36	Yes	No	0	9	8
20	R:R:F92	R:R:Q126	41.0646	5.86	Yes	Yes	0	6	7
21	R:R:F92	R:R:Y302	30.4286	15.47	Yes	Yes	1	6	7
22	R:R:D89	R:R:N61	47.2325	6.73	Yes	No	0	9	9
23	R:R:N61	R:R:P309	45.9894	6.52	No	No	0	9	9
24	R:R:P309	R:R:V64	44.7421	3.53	No	Yes	0	9	9
25	R:R:F319	R:R:V64	17.3706	5.24	Yes	Yes	2	8	9
26	R:R:F319	R:R:V67	10.9889	9.18	Yes	No	0	8	7
27	R:R:F127	R:R:Q126	22.3804	4.68	No	Yes	0	6	7
28	R:R:F127	R:R:S170	15.5318	2.64	No	No	0	6	7
29	R:R:S170	R:R:T128	19.3566	3.2	No	No	0	7	7
30	R:R:T128	R:R:W167	18.5099	12.13	No	No	0	7	9
31	R:R:T163	R:R:W167	17.659	2.43	No	No	0	7	9
32	R:R:N84	R:R:T163	16.804	16.08	No	No	0	9	7
33	R:R:I80	R:R:N84	15.9448	1.42	Yes	No	0	5	9
34	R:R:D89	R:R:N308	51.1715	6.73	Yes	No	3	9	9
35	R:R:F92	R:R:N125	10.5448	4.83	Yes	Yes	0	6	7
36	R:R:Q102	R:R:W108	32.1947	7.67	No	Yes	1	5	8
37	R:R:N186	R:R:R190	10.8706	3.62	No	Yes	0	1	1
38	R:R:Q126	R:R:W269	10.5033	9.86	Yes	Yes	0	7	8
39	R:R:F272	R:R:Y273	10.495	5.16	Yes	Yes	1	6	7
40	R:R:N308	R:R:Y312	50.111	4.65	No	No	0	9	9
41	R:R:R140	R:R:Y312	47.7265	6.17	No	No	0	9	9
42	R:R:R140	R:R:Y228	46.5913	2.06	No	Yes	0	9	9
43	R:R:S137	R:R:Y228	33.2303	3.82	No	Yes	0	9	9
44	R:R:C227	R:R:S137	30.6485	3.44	No	No	0	7	9
45	R:R:C227	R:R:Y141	29.3515	6.72	No	Yes	0	7	8
46	R:R:V145	R:R:Y141	13.5748	12.62	No	Yes	0	7	8
47	R:R:H146	R:R:V145	10.9889	4.15	Yes	No	0	5	7
48	R:R:I209	R:R:V280	15.0026	3.07	Yes	No	0	5	4
49	R:R:T206	R:R:V280	13.3382	1.59	No	No	0	3	4
50	R:R:I231	R:R:Y141	10.8768	2.42	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W188	3.86	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:P286	8.35	1	Yes	No	0	2	0	1
L:L:C2	R:R:F294	8.38	1	No	Yes	0	4	0	1
L:L:F3	R:R:W197	3.01	1	Yes	Yes	0	5	0	1
L:L:F3	R:R:Y205	14.44	1	Yes	No	0	4	0	1
L:L:F3	R:R:I209	5.02	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:I177	3.4	1	Yes	No	0	3	0	1
L:L:?4	R:R:T212	3.51	1	Yes	No	0	4	0	1
L:L:?4	R:R:F272	4.83	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N276	9.81	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:F294	2.9	1	Yes	Yes	0	4	0	1
L:L:K5	R:R:D122	5.53	1	Yes	Yes	0	6	0	1
L:L:K5	R:R:Q126	2.71	1	Yes	Yes	0	7	0	1
L:L:K5	R:R:Y302	3.58	1	Yes	Yes	0	7	0	1
L:L:T6	R:R:Q102	11.34	1	No	No	0	5	0	1
L:L:T6	R:R:S192	3.2	1	No	Yes	0	4	0	1
L:L:T6	R:R:T194	3.14	1	No	No	0	4	0	1
L:L:C7	R:R:F294	6.98	1	No	Yes	0	4	0	1
L:L:?8	R:R:R184	3.15	1	Yes	Yes	0	2	0	1
L:L:?8	R:R:N186	10.69	1	Yes	No	0	1	0	1
L:L:?8	R:R:W188	5.91	1	Yes	Yes	0	2	0	1
L:L:?8	R:R:S192	3.9	1	Yes	Yes	0	4	0	1
R:R:D122	R:R:F92	8.36	1	Yes	Yes	6	6	1	2
R:R:F92	R:R:Q126	5.86	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	15.47	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	11.72	0	Yes	Yes	7	7	2	1
R:R:Q102	R:R:W108	7.67	1	No	Yes	5	8	1	2
R:R:Q102	R:R:S192	4.33	1	No	Yes	5	4	1	1
R:R:V106	R:R:W188	2.45	0	No	Yes	4	2	2	1
R:R:R190	R:R:V106	11.77	0	Yes	No	1	4	2	2
R:R:D122	R:R:Y302	8.05	1	Yes	Yes	6	7	1	1
R:R:F127	R:R:Q126	4.68	0	No	Yes	6	7	2	1
R:R:Q126	R:R:W269	9.86	0	Yes	Yes	7	8	1	2
R:R:F208	R:R:I177	3.77	0	No	No	7	3	2	1
R:R:R184	R:R:T194	5.17	0	Yes	No	2	4	1	1
R:R:N196	R:R:R184	7.23	0	No	Yes	3	2	2	1
R:R:E200	R:R:R184	4.65	0	No	Yes	4	2	2	1
R:R:N186	R:R:W188	3.39	1	No	Yes	1	2	1	1
R:R:N186	R:R:R190	3.62	1	No	Yes	1	1	1	2
R:R:Q187	R:R:W188	7.67	0	No	Yes	2	2	2	1
R:R:K291	R:R:W188	3.48	0	No	Yes	3	2	2	1
R:R:S192	R:R:T194	6.4	1	Yes	No	4	4	1	1
R:R:I195	R:R:W197	4.7	0	No	Yes	5	5	2	1
R:R:P198	R:R:W197	2.7	1	No	Yes	5	5	2	1
R:R:W197	R:R:W204	6.56	1	Yes	No	5	3	1	2
R:R:W197	R:R:Y205	12.54	1	Yes	No	5	4	1	1
R:R:F208	R:R:W197	11.02	0	No	Yes	7	5	2	1
R:R:P198	R:R:W204	6.76	1	No	No	5	3	2	2
R:R:G202	R:R:Y205	2.9	0	No	No	2	4	2	1
R:R:F208	R:R:T212	7.78	0	No	No	7	4	2	1
R:R:I209	R:R:N276	2.83	0	Yes	Yes	5	6	1	1
R:R:I209	R:R:V280	3.07	0	Yes	No	5	4	1	2
R:R:W269	R:R:Y273	4.82	1	Yes	Yes	8	7	2	2
R:R:T301	R:R:W269	6.06	0	No	Yes	7	8	2	2
R:R:F272	R:R:Y273	5.16	1	Yes	Yes	6	7	1	2
R:R:F272	R:R:N276	8.46	1	Yes	Yes	6	6	1	1
R:R:F272	R:R:T301	5.19	1	Yes	No	6	7	1	2
R:R:F275	R:R:F294	8.57	0	No	Yes	4	4	2	1
R:R:F294	R:R:N276	3.62	1	Yes	Yes	4	6	1	1
R:R:F294	R:R:V298	3.93	1	Yes	No	4	6	1	2
R:R:P286	R:R:S285	1.78	0	No	No	2	2	1	2
R:R:D122	R:R:G123	1.68	1	Yes	No	6	4	1	2
R:R:I209	R:R:V277	1.54	0	Yes	No	5	5	1	2
R:R:I177	R:R:T120	1.52	0	No	No	3	6	1	2
R:R:L99	R:R:Y302	1.17	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T11_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.43
Number of Linked Nodes	269
Number of Links	302
Number of Hubs	36
Number of Links mediated by Hubs	140
Number of Communities	5
Number of Nodes involved in Communities	48
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	51
Number Of Links MetaPath	50
Number of Shortest Paths	83507
Length Of Smallest Path	3
Average Path Length	14.953
Length of Longest Path	30
Minimum Path Strength	1.265
Average Path Strength	5.9549
Maximum Path Strength	16.615
Minimum Path Correlation	0.7
Average Path Correlation	0.931657
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	44.104
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.2013
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • binding • neuropeptide binding • peptide binding • protein binding • PDZ domain binding • protein domain specific binding • G protein-coupled opioid receptor activity • dynorphin receptor activity • receptor serine/threonine kinase binding • signaling receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • G protein-coupled opioid receptor signaling pathway • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to stress • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • response to nitrogen compound • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • response to hexose • cellular response to carbohydrate stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • adenylate cyclase-inhibiting opioid receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • presynaptic membrane • dendrite • dendritic tree • endomembrane system • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • axon • axon terminus • distal axon • neuron projection terminus • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • GDP binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • cell division • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of autophagy • catabolic process • macroautophagy • autophagy • positive regulation of biological process • regulation of catabolic process • regulation of autophagy • positive regulation of catabolic process • positive regulation of metabolic process • regulation of macroautophagy • metabolic process • positive regulation of macroautophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of cellular process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • purine nucleoside triphosphate metabolic process • GTP metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • nucleoside triphosphate metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	THO
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	THO
Name	L-Threoninol
Synonyms	L-Threoninol
Identifier
Formula	C4 H11 N O2
Molecular Weight	105.136
SMILES
PubChem	2033049
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	2
Total Bonds	17
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7T11_nogp_Chain_R N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S G S K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V L V R L L S R E K D R N L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

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