psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G2	R:R:S201	3.71	No	No	0	0	2
2	L:L:C14	L:L:C3	7.28	No	No	0	0	0
3	L:L:K4	R:R:Y205	10.75	No	Yes	0	0	4
4	L:L:F6	L:L:N5	12.08	Yes	Yes	1	0	0
5	L:L:F11	L:L:N5	4.83	Yes	Yes	1	0	0
6	L:L:N5	R:R:I284	7.08	Yes	No	0	0	1
7	L:L:F11	L:L:F6	13.93	Yes	Yes	1	0	0
8	L:L:F6	R:R:F275	5.36	Yes	No	1	0	4
9	L:L:F6	R:R:F294	32.15	Yes	Yes	1	0	4
10	L:L:F7	R:R:W197	9.02	No	Yes	2	0	5
11	L:L:F7	R:R:Y205	10.32	No	Yes	2	0	4
12	L:L:F7	R:R:F208	6.43	No	Yes	2	0	7
13	L:L:K9	L:L:W8	10.44	Yes	No	0	0	0
14	L:L:W8	R:R:Q126	8.76	No	No	0	0	7
15	L:L:W8	R:R:T212	8.49	No	No	0	0	4
16	L:L:K9	R:R:D122	12.44	Yes	Yes	1	0	6
17	L:L:K9	R:R:Y302	4.78	Yes	Yes	1	0	7
18	L:L:T10	L:L:T12	3.14	No	No	3	0	0
19	L:L:T10	R:R:Q102	5.67	No	No	0	0	5
20	L:L:T10	R:R:T194	6.28	No	No	3	0	4
21	L:L:F11	R:R:K291	13.65	Yes	Yes	0	0	3
22	L:L:T12	R:R:S192	9.59	No	No	0	0	4
23	L:L:T12	R:R:T194	6.28	No	No	3	0	4
24	L:L:S13	R:R:N186	4.47	No	No	0	0	1
25	R:R:D39	R:R:S42	4.42	No	No	0	5	4
26	R:R:D39	R:R:P288	4.83	No	No	0	5	3
27	R:R:N43	R:R:S42	2.98	No	No	0	3	4
28	R:R:K291	R:R:N43	4.2	Yes	No	0	3	3
29	R:R:D295	R:R:L46	8.14	Yes	No	0	2	5
30	R:R:I49	R:R:V299	3.07	No	No	0	5	5
31	R:R:L96	R:R:Y50	3.52	Yes	Yes	1	7	7
32	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
33	R:R:V103	R:R:Y50	10.09	No	Yes	1	4	7
34	R:R:D295	R:R:Y50	4.6	Yes	Yes	1	2	7
35	R:R:V298	R:R:Y50	7.57	No	Yes	0	6	7
36	R:R:V299	R:R:Y50	8.83	No	Yes	0	5	7
37	R:R:V299	R:R:V53	4.81	No	No	0	5	7
38	R:R:C54	R:R:L96	7.94	No	Yes	1	6	7
39	R:R:C54	R:R:P97	3.77	No	No	1	6	8
40	R:R:D89	R:R:N61	16.16	Yes	No	1	9	9
41	R:R:E90	R:R:N61	7.89	No	No	0	7	9
42	R:R:N61	R:R:P309	4.89	No	No	1	9	9
43	R:R:E90	R:R:T62	4.23	No	No	0	7	5
44	R:R:I68	R:R:V64	3.07	Yes	No	0	7	9
45	R:R:A313	R:R:V64	3.39	No	No	0	7	9
46	R:R:A86	R:R:I65	3.25	No	No	0	9	7
47	R:R:E90	R:R:I65	4.1	No	No	0	7	7
48	R:R:Y66	R:R:Y71	3.97	No	Yes	0	3	6
49	R:R:V67	R:R:Y71	5.05	No	Yes	0	7	6
50	R:R:F319	R:R:V67	9.18	Yes	No	0	8	7
51	R:R:F323	R:R:V67	6.55	No	No	0	6	7
52	R:R:I68	R:R:I82	2.94	Yes	No	0	7	8
53	R:R:I68	R:R:L83	9.99	Yes	No	0	7	6
54	R:R:F319	R:R:I68	3.77	Yes	Yes	0	8	7
55	R:R:R70	R:R:Y71	3.09	No	Yes	0	4	6
56	R:R:A72	R:R:N79	3.13	No	No	0	5	8
57	R:R:N79	R:R:T76	13.16	No	No	0	8	7
58	R:R:I77	R:R:Y81	4.84	No	Yes	0	4	7
59	R:R:I77	R:R:R154	10.02	No	Yes	0	4	5
60	R:R:I82	R:R:T78	3.04	No	No	0	8	8
61	R:R:D139	R:R:Y81	9.2	No	Yes	0	8	7
62	R:R:A159	R:R:Y81	4	No	Yes	0	7	7
63	R:R:I162	R:R:Y81	3.63	No	Yes	0	5	7
64	R:R:I82	R:R:M136	2.92	No	No	0	8	9
65	R:R:I87	R:R:L83	4.28	No	No	0	7	6
66	R:R:C132	R:R:N84	3.15	No	No	0	8	9
67	R:R:N84	R:R:T163	2.92	No	No	0	9	7
68	R:R:N84	R:R:W167	6.78	No	No	0	9	9
69	R:R:L85	R:R:S129	3	No	No	0	9	9
70	R:R:A88	R:R:T128	3.36	No	No	0	8	7
71	R:R:D89	R:R:M93	6.93	Yes	Yes	1	9	6
72	R:R:D89	R:R:S305	7.36	Yes	No	1	9	8
73	R:R:D89	R:R:P309	8.05	Yes	No	1	9	9
74	R:R:L91	R:R:N125	6.87	No	Yes	0	7	7
75	R:R:D122	R:R:F92	8.36	Yes	Yes	1	6	6
76	R:R:F92	R:R:N125	6.04	Yes	Yes	0	6	7
77	R:R:F92	R:R:Y302	21.66	Yes	Yes	1	6	7
78	R:R:F92	R:R:S305	7.93	Yes	No	1	6	8
79	R:R:M93	R:R:Y302	7.18	Yes	Yes	1	6	7
80	R:R:M93	R:R:S305	3.07	Yes	No	1	6	8
81	R:R:L96	R:R:P97	3.28	Yes	No	1	7	8
82	R:R:L96	R:R:Y302	19.93	Yes	Yes	1	7	7
83	R:R:F110	R:R:F98	5.36	Yes	No	0	6	5
84	R:R:F98	R:R:V118	6.55	No	No	0	5	5
85	R:R:F110	R:R:M101	3.73	Yes	No	0	6	5
86	R:R:Q102	R:R:W108	10.95	No	Yes	0	5	8
87	R:R:D295	R:R:V103	7.3	Yes	No	1	2	4
88	R:R:R190	R:R:V106	10.46	No	No	0	1	4
89	R:R:H107	R:R:P109	10.68	Yes	No	0	4	4
90	R:R:H107	R:R:S191	4.18	Yes	No	0	4	5
91	R:R:F110	R:R:W108	25.05	Yes	Yes	0	6	8
92	R:R:C115	R:R:W108	6.53	No	Yes	5	9	8
93	R:R:C193	R:R:W108	3.92	No	Yes	5	9	8
94	R:R:F110	R:R:I114	3.77	Yes	No	0	6	6
95	R:R:K112	R:R:R116	6.19	No	No	0	3	6
96	R:R:G182	R:R:K112	3.49	No	No	0	5	3
97	R:R:C115	R:R:C193	7.28	No	No	5	9	9
98	R:R:A181	R:R:R116	4.15	No	No	0	4	6
99	R:R:M178	R:R:T120	7.53	No	No	0	5	6
100	R:R:N125	R:R:V121	4.43	Yes	No	0	7	5
101	R:R:D122	R:R:Y302	6.9	Yes	Yes	1	6	7
102	R:R:I124	R:R:N125	4.25	Yes	Yes	0	5	7
103	R:R:I124	R:R:W167	4.7	Yes	No	0	5	9
104	R:R:I124	R:R:S170	6.19	Yes	No	0	5	7
105	R:R:I124	R:R:L171	5.71	Yes	No	0	5	3
106	R:R:I124	R:R:I174	2.94	Yes	No	0	5	7
107	R:R:Q126	R:R:W269	6.57	No	Yes	0	7	8
108	R:R:F127	R:R:F131	4.29	No	No	0	6	6
109	R:R:F127	R:R:V173	10.49	No	No	0	6	4
110	R:R:F127	R:R:T212	3.89	No	No	0	6	4
111	R:R:T128	R:R:W167	18.19	No	No	0	7	9
112	R:R:S170	R:R:T128	3.2	No	No	0	7	7
113	R:R:I130	R:R:P220	3.39	No	Yes	0	8	9
114	R:R:I130	R:R:W269	7.05	No	Yes	0	8	8
115	R:R:F131	R:R:V169	6.55	No	No	0	6	4
116	R:R:L133	R:R:N308	6.87	No	No	0	9	9
117	R:R:L133	R:R:Y312	3.52	No	Yes	0	9	9
118	R:R:P220	R:R:T134	3.5	Yes	No	0	9	7
119	R:R:I223	R:R:T134	4.56	Yes	No	0	6	7
120	R:R:I162	R:R:V135	4.61	No	No	0	5	7
121	R:R:V135	R:R:V166	3.21	No	No	0	7	6
122	R:R:M136	R:R:R140	6.2	No	No	4	9	9
123	R:R:M136	R:R:Y312	9.58	No	Yes	4	9	9
124	R:R:I224	R:R:S137	7.74	No	No	0	7	9
125	R:R:C227	R:R:S137	5.16	No	No	0	7	9
126	R:R:I138	R:R:I223	2.94	No	Yes	0	6	6
127	R:R:C227	R:R:I138	3.27	No	No	0	7	6
128	R:R:D139	R:R:R154	9.53	No	Yes	0	8	5
129	R:R:R140	R:R:Y228	6.17	No	Yes	0	9	9
130	R:R:R140	R:R:Y312	5.14	No	Yes	4	9	9
131	R:R:L142	R:R:Y141	4.69	No	Yes	0	4	8
132	R:R:V145	R:R:Y141	6.31	No	Yes	0	7	8
133	R:R:C227	R:R:Y141	6.72	No	Yes	0	7	8
134	R:R:F230	R:R:Y141	9.28	No	Yes	0	4	8
135	R:R:L142	R:R:W153	5.69	No	No	0	4	3
136	R:R:A143	R:R:R154	4.15	No	Yes	0	8	5
137	R:R:I231	R:R:V144	13.83	No	No	0	9	8
138	R:R:K234	R:R:V144	3.04	No	No	0	5	8
139	R:R:H146	R:R:V145	6.92	Yes	No	0	5	7
140	R:R:K234	R:R:V145	9.11	No	No	0	5	7
141	R:R:H146	R:R:K149	6.55	Yes	No	6	5	4
142	R:R:H146	R:R:W153	3.17	Yes	No	6	5	3
143	R:R:I148	R:R:P147	3.39	No	No	0	5	8
144	R:R:K149	R:R:K152	5.75	No	No	0	4	4
145	R:R:K149	R:R:W153	12.76	No	No	6	4	3
146	R:R:R154	R:R:S150	3.95	Yes	No	0	5	5
147	R:R:R155	R:R:T158	7.76	No	No	0	6	5
148	R:R:I162	R:R:T158	3.04	No	No	0	5	5
149	R:R:L215	R:R:V173	4.47	No	No	0	4	4
150	R:R:I174	R:R:I177	5.89	No	No	0	7	3
151	R:R:F208	R:R:P176	5.78	Yes	No	0	7	8
152	R:R:I177	R:R:I195	2.94	No	No	0	3	5
153	R:R:F208	R:R:I177	3.77	Yes	No	0	7	3
154	R:R:I179	R:R:Y180	12.09	No	Yes	0	4	4
155	R:R:W197	R:R:Y180	6.75	Yes	Yes	2	5	4
156	R:R:P198	R:R:Y180	6.95	No	Yes	0	5	4
157	R:R:W204	R:R:Y180	3.86	No	Yes	2	3	4
158	R:R:G182	R:R:N196	3.39	No	No	0	5	3
159	R:R:L183	R:R:S191	3	No	No	0	4	5
160	R:R:C193	R:R:L183	4.76	No	No	0	9	4
161	R:R:N196	R:R:R184	18.08	No	No	0	3	2
162	R:R:N186	R:R:R190	4.82	No	No	0	1	1
163	R:R:I195	R:R:W197	7.05	No	Yes	0	5	5
164	R:R:W197	R:R:W204	11.25	Yes	No	2	5	3
165	R:R:W197	R:R:Y205	14.47	Yes	Yes	2	5	4
166	R:R:F208	R:R:W197	11.02	Yes	Yes	2	7	5
167	R:R:G207	R:R:I210	3.53	No	No	0	4	5
168	R:R:I209	R:R:N276	4.25	Yes	No	0	5	6
169	R:R:I209	R:R:V280	4.61	Yes	No	0	5	4
170	R:R:L215	R:R:Y211	7.03	No	No	0	4	4
171	R:R:T212	R:R:Y273	6.24	No	Yes	0	4	7
172	R:R:F213	R:R:F217	9.65	No	No	7	5	8
173	R:R:F213	R:R:L218	4.87	No	No	0	5	4
174	R:R:F213	R:R:Y273	10.32	No	Yes	7	5	7
175	R:R:G216	R:R:P220	4.06	No	Yes	0	6	9
176	R:R:F217	R:R:L270	6.09	No	Yes	0	8	5
177	R:R:F217	R:R:Y273	12.38	No	Yes	7	8	7
178	R:R:P220	R:R:V219	3.53	Yes	No	0	9	5
179	R:R:I223	R:R:V219	3.07	Yes	No	0	6	5
180	R:R:C225	R:R:L221	3.17	No	No	0	5	6
181	R:R:F265	R:R:L221	3.65	No	No	0	9	6
182	R:R:I266	R:R:L221	4.28	No	No	0	6	6
183	R:R:I224	R:R:Y228	4.84	No	Yes	0	7	9
184	R:R:V258	R:R:Y228	15.14	No	Yes	0	8	9
185	R:R:V261	R:R:Y228	5.05	No	Yes	0	8	9
186	R:R:I232	R:R:V254	3.07	No	No	0	5	8
187	R:R:I232	R:R:T255	3.04	No	No	0	5	7
188	R:R:K234	R:R:S237	4.59	No	No	0	5	5
189	R:R:K236	R:R:R247	7.43	No	Yes	8	4	4
190	R:R:E251	R:R:K236	12.15	No	No	8	6	4
191	R:R:G239	R:R:R247	6	No	Yes	0	5	4
192	R:R:I240	R:R:R247	3.76	No	Yes	0	3	4
193	R:R:K246	R:R:K249	4.31	No	No	0	3	4
194	R:R:E251	R:R:R247	6.98	No	Yes	8	6	4
195	R:R:L315	R:R:M257	4.24	No	No	0	6	8
196	R:R:A263	R:R:F267	4.16	No	No	0	5	6
197	R:R:N304	R:R:V264	2.96	Yes	No	0	9	7
198	R:R:F265	R:R:W269	8.02	No	Yes	0	9	8
199	R:R:I266	R:R:L270	4.28	No	Yes	0	6	5
200	R:R:C268	R:R:L300	3.17	No	No	0	8	7
201	R:R:C268	R:R:N304	3.15	No	Yes	0	8	9
202	R:R:W269	R:R:Y273	3.86	Yes	Yes	0	8	7
203	R:R:T301	R:R:W269	7.28	No	Yes	0	7	8
204	R:R:N304	R:R:W269	6.78	Yes	Yes	0	9	8
205	R:R:L270	R:R:P271	3.28	Yes	No	0	5	9
206	R:R:F272	R:R:N276	9.67	Yes	No	1	6	6
207	R:R:F272	R:R:F294	3.22	Yes	Yes	1	6	4
208	R:R:F272	R:R:V297	5.24	Yes	No	0	6	7
209	R:R:F272	R:R:T301	3.89	Yes	No	0	6	7
210	R:R:F275	R:R:L290	4.87	No	No	0	4	4
211	R:R:F275	R:R:F294	9.65	No	Yes	1	4	4
212	R:R:F294	R:R:N276	4.83	Yes	No	1	4	6
213	R:R:S279	R:R:V280	3.23	No	No	0	4	4
214	R:R:I284	R:R:L290	4.28	No	No	0	1	4
215	R:R:P288	R:R:T287	5.25	No	No	0	3	1
216	R:R:L290	R:R:T287	7.37	No	No	0	4	1
217	R:R:D295	R:R:K291	5.53	Yes	Yes	0	2	3
218	R:R:M293	R:R:V297	3.04	No	No	0	4	7
219	R:R:D295	R:R:F294	4.78	Yes	Yes	1	2	4
220	R:R:F296	R:R:L300	9.74	No	No	0	5	7
221	R:R:N304	R:R:N308	12.26	Yes	No	0	9	9
222	R:R:F314	R:R:I310	10.05	No	No	0	7	6
223	R:R:L311	R:R:L315	4.15	No	No	0	8	6
224	R:R:A313	R:R:F319	8.32	No	Yes	0	7	8
225	R:R:N318	R:R:S316	7.45	No	No	0	5	8
226	R:R:F323	R:R:K320	4.96	No	No	0	6	8
227	R:R:I65	R:R:L69	2.85	No	No	0	7	3
228	R:R:K112	R:R:L183	2.82	No	No	0	3	4
229	L:L:F11	L:L:S13	2.64	Yes	No	0	0	0
230	R:R:F319	R:R:S316	2.64	Yes	No	0	8	8
231	R:R:F131	R:R:V166	2.62	No	No	0	6	6
232	R:R:S201	R:R:Y205	2.54	No	Yes	0	2	4
233	R:R:F314	R:R:L63	2.44	No	No	0	7	6
234	R:R:F323	R:R:L63	2.44	No	No	0	6	6
235	R:R:L85	R:R:Y312	2.34	No	Yes	0	9	9
236	R:R:L311	R:R:Y312	2.34	No	Yes	0	8	9
237	R:R:H107	R:R:R190	2.26	Yes	No	0	4	1
238	R:R:G95	R:R:P97	2.03	No	No	0	6	8
239	R:R:G199	R:R:P198	2.03	No	No	0	3	5
240	L:L:C3	L:L:G2	1.96	No	No	0	0	0
241	R:R:C306	R:R:G57	1.96	No	No	0	8	8
242	L:L:A1	L:L:G2	1.95	No	No	0	0	0
243	R:R:G202	R:R:S201	1.86	No	No	0	2	2
244	R:R:G239	R:R:V242	1.84	No	No	0	5	3
245	R:R:G243	R:R:V242	1.84	No	No	0	1	3
246	R:R:G207	R:R:T206	1.82	No	No	0	4	3
247	R:R:P286	R:R:S285	1.78	No	No	0	2	2
248	R:R:G57	R:R:I56	1.76	No	No	0	8	4
249	R:R:G111	R:R:I114	1.76	No	No	0	7	6
250	R:R:G57	R:R:M93	1.75	No	Yes	0	8	6
251	R:R:G292	R:R:K291	1.74	No	Yes	0	1	3
252	R:R:A303	R:R:V53	1.7	No	No	0	5	7
253	R:R:A104	R:R:T47	1.68	No	No	0	5	5
254	R:R:D122	R:R:G123	1.68	Yes	No	0	6	4
255	R:R:A289	R:R:T287	1.68	No	No	0	1	1
256	R:R:L175	R:R:P176	1.64	No	No	0	4	8
257	L:L:N5	R:R:P286	1.63	Yes	No	0	0	2
258	R:R:A159	R:R:I80	1.62	No	No	0	7	5
259	R:R:C115	R:R:M119	1.62	No	No	0	9	5
260	R:R:S250	R:R:V235	1.62	No	No	0	5	8
261	R:R:S244	R:R:V242	1.62	No	No	0	3	3
262	R:R:V144	R:R:V235	1.6	No	No	0	8	8
263	R:R:V254	R:R:V258	1.6	No	No	0	8	8
264	R:R:S259	R:R:T255	1.6	No	No	0	4	7
265	R:R:V258	R:R:V262	1.6	No	No	0	8	7
266	R:R:A104	R:R:L105	1.58	No	No	0	5	5
267	R:R:T76	R:R:T78	1.57	No	No	0	7	8
268	R:R:I233	R:R:S237	1.55	No	No	0	3	5
269	R:R:I209	R:R:V277	1.54	Yes	No	0	5	5
270	R:R:I214	R:R:V219	1.54	No	No	0	4	5
271	R:R:H146	R:R:P147	1.53	Yes	No	0	5	8
272	R:R:K246	R:R:S244	1.53	No	No	0	3	3
273	R:R:I174	R:R:T120	1.52	No	No	0	7	6
274	R:R:I209	R:R:T206	1.52	Yes	No	0	5	3
275	R:R:I223	R:R:T222	1.52	Yes	No	0	6	4
276	R:R:K75	R:R:T76	1.5	No	No	0	7	7
277	R:R:I80	R:R:M74	1.46	No	No	0	5	7
278	R:R:I260	R:R:M257	1.46	No	No	0	6	8
279	R:R:I233	R:R:K236	1.45	No	No	0	3	4
280	R:R:K73	R:R:K75	1.44	No	No	0	5	7
281	R:R:P156	R:R:R155	1.44	No	No	0	3	6
282	R:R:M161	R:R:M164	1.44	No	No	0	1	4
283	R:R:K248	R:R:K249	1.44	No	No	0	3	4
284	R:R:K252	R:R:K253	1.44	No	No	0	5	7
285	R:R:I274	R:R:L270	1.43	No	Yes	0	5	5
286	L:L:K9	R:R:L99	1.41	Yes	No	0	0	6
287	R:R:C54	R:R:F51	1.4	No	No	0	6	5
288	R:R:C268	R:R:F267	1.4	No	No	0	8	6
289	R:R:D317	R:R:N318	1.35	No	No	0	5	5
290	R:R:A203	R:R:W204	1.3	No	No	0	1	3
291	R:R:H107	R:R:L105	1.29	Yes	No	0	4	5
292	R:R:S322	R:R:Y71	1.27	No	Yes	0	5	6
293	R:R:F230	R:R:L226	1.22	No	No	0	4	5
294	R:R:Q187	R:R:W188	1.1	No	No	0	2	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:N5	6.405	4	1	0
2	L:L:F6	15.88	4	1	0
3	L:L:K9	7.2675	4	1	0
4	L:L:F11	8.7625	4	1	0
5	R:R:Y50	6.435	6	1	7
6	R:R:I68	4.9425	4	0	7
7	R:R:Y71	3.345	4	0	6
8	R:R:Y81	5.4175	4	0	7
9	R:R:D89	9.625	4	1	9
10	R:R:F92	10.9975	4	1	6
11	R:R:M93	4.7325	4	1	6
12	R:R:L96	8.6675	4	1	7
13	R:R:H107	4.6025	4	0	4
14	R:R:W108	11.6125	4	5	8
15	R:R:F110	9.4775	4	0	6
16	R:R:D122	7.345	4	1	6
17	R:R:I124	4.758	5	0	5
18	R:R:N125	5.3975	4	0	7
19	R:R:Y141	6.75	4	0	8
20	R:R:H146	4.5425	4	6	5
21	R:R:R154	6.9125	4	0	5
22	R:R:Y180	7.4125	4	2	4
23	R:R:W197	9.92667	6	2	5
24	R:R:Y205	9.52	4	2	4
25	R:R:F208	6.75	4	2	7
26	R:R:I209	2.98	4	0	5
27	R:R:P220	3.62	4	0	9
28	R:R:I223	3.0225	4	0	6
29	R:R:Y228	7.8	4	0	9
30	R:R:R247	6.0425	4	8	4
31	R:R:W269	6.59333	6	0	8
32	R:R:L270	3.77	4	0	5
33	R:R:F272	5.505	4	1	6
34	R:R:Y273	8.2	4	7	7
35	R:R:K291	6.28	4	0	3
36	R:R:F294	10.926	5	1	4
37	R:R:D295	6.07	5	1	2
38	R:R:Y302	12.09	5	1	7
39	R:R:N304	6.2875	4	0	9
40	R:R:Y312	4.584	5	4	9
41	R:R:F319	5.9775	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C3	L:L:G2	10.4048	1.96	No	No	0	0	0
2	L:L:G2	R:R:S201	20.7841	3.71	No	No	0	0	2
3	R:R:S201	R:R:Y205	31.1343	2.54	No	Yes	0	2	4
4	L:L:F6	R:R:F294	27.0175	32.15	Yes	Yes	1	0	4
5	R:R:D295	R:R:F294	16.7436	4.78	Yes	Yes	1	2	4
6	R:R:D295	R:R:Y50	27.4357	4.6	Yes	Yes	1	2	7
7	R:R:L96	R:R:Y50	25.461	3.52	Yes	Yes	1	7	7
8	R:R:L96	R:R:Y302	28.6613	19.93	Yes	Yes	1	7	7
9	R:R:F92	R:R:Y302	59.6392	21.66	Yes	Yes	1	6	7
10	R:R:F92	R:R:N125	100	6.04	Yes	Yes	0	6	7
11	R:R:I124	R:R:N125	95.7013	4.25	Yes	Yes	0	5	7
12	R:R:I124	R:R:I174	79.3796	2.94	Yes	No	0	5	7
13	R:R:I174	R:R:I177	74.7754	5.89	No	No	0	7	3
14	R:R:I177	R:R:I195	27.2321	2.94	No	No	0	3	5
15	R:R:I195	R:R:W197	25.581	7.05	No	Yes	0	5	5
16	R:R:W197	R:R:Y205	27.4248	14.47	Yes	Yes	2	5	4
17	R:R:F208	R:R:I177	46.005	3.77	Yes	No	0	7	3
18	R:R:F208	R:R:W197	25.6864	11.02	Yes	Yes	2	7	5
19	L:L:F7	R:R:F208	15.4781	6.43	No	Yes	2	0	7
20	L:L:F7	R:R:Y205	13.787	10.32	No	Yes	2	0	4
21	R:R:D295	R:R:K291	18.8821	5.53	Yes	Yes	0	2	3
22	L:L:F11	R:R:K291	13.8706	13.65	Yes	Yes	0	0	3
23	R:R:D122	R:R:F92	40.4808	8.36	Yes	Yes	1	6	6
24	L:L:K9	R:R:D122	41.2445	12.44	Yes	Yes	1	0	6
25	L:L:K9	R:R:Y302	54.2677	4.78	Yes	Yes	1	0	7
26	L:L:K9	L:L:W8	95.254	10.44	Yes	No	0	0	0
27	L:L:W8	R:R:Q126	75.9392	8.76	No	No	0	0	7
28	L:L:W8	R:R:T212	19.5258	8.49	No	No	0	0	4
29	L:L:F11	L:L:S13	35.0656	2.64	Yes	No	0	0	0
30	L:L:S13	R:R:N186	34.0801	4.47	No	No	0	0	1
31	R:R:N186	R:R:R190	33.0872	4.82	No	No	0	1	1
32	R:R:H107	R:R:R190	31.0798	2.26	Yes	No	0	4	1
33	R:R:H107	R:R:S191	25.9337	4.18	Yes	No	0	4	5
34	R:R:L183	R:R:S191	24.8827	3	No	No	0	4	5
35	R:R:C193	R:R:L183	17.3219	4.76	No	No	0	9	4
36	R:R:C193	R:R:W108	13.8852	3.92	No	Yes	5	9	8
37	R:R:Q126	R:R:W269	76.0556	6.57	No	Yes	0	7	8
38	R:R:N304	R:R:W269	53.7768	6.78	Yes	Yes	0	9	8
39	R:R:N304	R:R:N308	46.4196	12.26	Yes	No	0	9	9
40	R:R:L133	R:R:N308	45.6886	6.87	No	No	0	9	9
41	R:R:L133	R:R:Y312	44.9358	3.52	No	Yes	0	9	9
42	R:R:M136	R:R:Y312	28.745	9.58	No	Yes	4	9	9
43	R:R:I82	R:R:M136	32.5926	2.92	No	No	0	8	9
44	R:R:I68	R:R:I82	24.6463	2.94	Yes	No	0	7	8
45	R:R:F319	R:R:I68	18.7584	3.77	Yes	Yes	0	8	7
46	R:R:F319	R:R:V67	12.725	9.18	Yes	No	0	8	7
47	R:R:F127	R:R:T212	32.6472	3.89	No	No	0	6	4
48	R:R:F127	R:R:F131	27.4866	4.29	No	No	0	6	6
49	R:R:F131	R:R:V166	24.8536	2.62	No	No	0	6	6
50	R:R:V135	R:R:V166	23.5262	3.21	No	No	0	7	6
51	R:R:I162	R:R:V135	22.1915	4.61	No	No	0	5	7
52	R:R:I162	R:R:Y81	16.7691	3.63	No	Yes	0	5	7
53	R:R:I124	R:R:W167	11.0085	4.7	Yes	No	0	5	9
54	R:R:M93	R:R:Y302	13.136	7.18	Yes	Yes	1	6	7
55	R:R:I130	R:R:W269	76.5902	7.05	No	Yes	0	8	8
56	R:R:I130	R:R:P220	75.7355	3.39	No	Yes	0	8	9
57	R:R:P220	R:R:T134	36.5349	3.5	Yes	No	0	9	7
58	R:R:I223	R:R:T134	35.6839	4.56	Yes	No	0	6	7
59	R:R:P220	R:R:V219	37.655	3.53	Yes	No	0	9	5
60	R:R:I223	R:R:V219	35.953	3.07	Yes	No	0	6	5
61	R:R:R140	R:R:Y312	11.0194	5.14	No	Yes	4	9	9
62	R:R:R140	R:R:Y228	15.078	6.17	No	Yes	0	9	9
63	R:R:I138	R:R:I223	68.2074	2.94	No	Yes	0	6	6
64	R:R:C227	R:R:I138	66.4982	3.27	No	No	0	7	6
65	R:R:C227	R:R:Y141	66.9782	6.72	No	Yes	0	7	8
66	R:R:V145	R:R:Y141	52.1111	6.31	No	Yes	0	7	8
67	R:R:K234	R:R:V145	39.4734	9.11	No	No	0	5	7
68	R:R:H146	R:R:V145	11.3212	6.92	Yes	No	0	5	7
69	R:R:W197	R:R:Y180	13.8742	6.75	Yes	Yes	2	5	4
70	R:R:T212	R:R:Y273	23.4571	6.24	No	Yes	0	4	7
71	R:R:K234	R:R:S237	28.745	4.59	No	No	0	5	5
72	R:R:I233	R:R:S237	26.5593	1.55	No	No	0	3	5
73	R:R:I233	R:R:K236	24.3663	1.45	No	No	0	3	4
74	R:R:K236	R:R:R247	20.0385	7.43	No	Yes	8	4	4
75	R:R:G239	R:R:R247	15.7544	6	No	Yes	0	5	4
76	R:R:G239	R:R:V242	13.5251	1.84	No	No	0	5	3
77	R:R:T301	R:R:W269	44.9285	7.28	No	Yes	0	7	8
78	R:R:F272	R:R:F294	38.6624	3.22	Yes	Yes	1	6	4
79	R:R:F272	R:R:T301	44.063	3.89	Yes	No	0	6	7
80	R:R:W269	R:R:Y273	23.4935	3.86	Yes	Yes	0	8	7
81	L:L:F11	L:L:F6	22.7443	13.93	Yes	Yes	1	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G2	R:R:S201	3.71	0	No	No	0	2	0	1
L:L:K4	R:R:Y205	10.75	0	No	Yes	0	4	0	1
L:L:N5	R:R:I284	7.08	1	Yes	No	0	1	0	1
L:L:F6	R:R:F275	5.36	1	Yes	No	0	4	0	1
L:L:F6	R:R:F294	32.15	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:W197	9.02	2	No	Yes	0	5	0	1
L:L:F7	R:R:Y205	10.32	2	No	Yes	0	4	0	1
L:L:F7	R:R:F208	6.43	2	No	Yes	0	7	0	1
L:L:W8	R:R:Q126	8.76	0	No	No	0	7	0	1
L:L:W8	R:R:T212	8.49	0	No	No	0	4	0	1
L:L:K9	R:R:D122	12.44	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:Y302	4.78	1	Yes	Yes	0	7	0	1
L:L:T10	R:R:Q102	5.67	3	No	No	0	5	0	1
L:L:T10	R:R:T194	6.28	3	No	No	0	4	0	1
L:L:F11	R:R:K291	13.65	1	Yes	Yes	0	3	0	1
L:L:T12	R:R:S192	9.59	3	No	No	0	4	0	1
L:L:T12	R:R:T194	6.28	3	No	No	0	4	0	1
L:L:S13	R:R:N186	4.47	0	No	No	0	1	0	1
R:R:K291	R:R:N43	4.2	0	Yes	No	3	3	1	2
R:R:D122	R:R:F92	8.36	1	Yes	Yes	6	6	1	2
R:R:F92	R:R:Y302	21.66	1	Yes	Yes	6	7	2	1
R:R:M93	R:R:Y302	7.18	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	19.93	1	Yes	Yes	7	7	2	1
R:R:Q102	R:R:W108	10.95	0	No	Yes	5	8	1	2
R:R:D122	R:R:Y302	6.9	1	Yes	Yes	6	7	1	1
R:R:Q126	R:R:W269	6.57	0	No	Yes	7	8	1	2
R:R:F127	R:R:T212	3.89	0	No	No	6	4	2	1
R:R:F208	R:R:P176	5.78	2	Yes	No	7	8	1	2
R:R:I177	R:R:I195	2.94	0	No	No	3	5	2	2
R:R:F208	R:R:I177	3.77	2	Yes	No	7	3	1	2
R:R:W197	R:R:Y180	6.75	2	Yes	Yes	5	4	1	2
R:R:W204	R:R:Y180	3.86	2	No	Yes	3	4	2	2
R:R:N186	R:R:R190	4.82	0	No	No	1	1	1	2
R:R:I195	R:R:W197	7.05	0	No	Yes	5	5	2	1
R:R:W197	R:R:W204	11.25	2	Yes	No	5	3	1	2
R:R:W197	R:R:Y205	14.47	2	Yes	Yes	5	4	1	1
R:R:F208	R:R:W197	11.02	2	Yes	Yes	7	5	1	1
R:R:T212	R:R:Y273	6.24	0	No	Yes	4	7	1	2
R:R:W269	R:R:Y273	3.86	0	Yes	Yes	8	7	2	2
R:R:F272	R:R:N276	9.67	1	Yes	No	6	6	2	2
R:R:F272	R:R:F294	3.22	1	Yes	Yes	6	4	2	1
R:R:F275	R:R:L290	4.87	1	No	No	4	4	1	2
R:R:F275	R:R:F294	9.65	1	No	Yes	4	4	1	1
R:R:F294	R:R:N276	4.83	1	Yes	No	4	6	1	2
R:R:I284	R:R:L290	4.28	0	No	No	1	4	1	2
R:R:D295	R:R:K291	5.53	1	Yes	Yes	2	3	2	1
R:R:D295	R:R:F294	4.78	1	Yes	Yes	2	4	2	1
R:R:S201	R:R:Y205	2.54	0	No	Yes	2	4	1	1
R:R:G202	R:R:S201	1.86	0	No	No	2	2	2	1
R:R:P286	R:R:S285	1.78	0	No	No	2	2	1	2
R:R:G292	R:R:K291	1.74	0	No	Yes	1	3	2	1
R:R:D122	R:R:G123	1.68	1	Yes	No	6	4	1	2
L:L:N5	R:R:P286	1.63	1	Yes	No	0	2	0	1
L:L:K9	R:R:L99	1.41	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XMR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	266
Number of Links	294
Number of Hubs	41
Number of Links mediated by Hubs	148
Number of Communities	8
Number of Nodes involved in Communities	46
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	61358
Length Of Smallest Path	3
Average Path Length	16.7097
Length of Longest Path	37
Minimum Path Strength	1.435
Average Path Strength	6.29343
Maximum Path Strength	22.115
Minimum Path Correlation	0.7
Average Path Correlation	0.926426
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	41.8724
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.6284
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cerebellum development • metencephalon development • hindbrain development • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • signaling receptor regulator activity • receptor ligand activity • response to acid chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • regulation of biological quality • somatostatin signaling pathway • hormone-mediated signaling pathway • somatostatin receptor signaling pathway • regulation of cell motility • regulation of locomotion • regulation of cell migration • locomotion • response to osmotic stress • hyperosmotic response • response to stress • response to abiotic stimulus • cell surface receptor signaling pathway • negative regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to steroid hormone • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient levels • response to nutrient • response to pH • response to acidic pH • digestion • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • GABA-ergic synapse • somatodendritic compartment • cell body • neuronal cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7XMR_nogp_Chain_R D L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

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Download 7XMR_nogp.zip

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