psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C14	L:L:C3	7.28	No	No	0	0	0
2	L:L:K4	R:R:Y205	4.78	No	Yes	0	0	4
3	L:L:F11	L:L:N5	12.08	Yes	Yes	2	0	0
4	L:L:C14	L:L:N5	6.3	No	Yes	2	0	0
5	L:L:N5	R:R:P286	4.89	Yes	No	2	0	2
6	L:L:N5	R:R:L290	8.24	Yes	No	0	0	4
7	L:L:F6	L:L:F7	6.43	Yes	Yes	1	0	0
8	L:L:F6	R:R:Y205	12.38	Yes	Yes	1	0	4
9	L:L:F6	R:R:I209	5.02	Yes	No	1	0	5
10	L:L:F6	R:R:N276	19.33	Yes	No	1	0	6
11	L:L:F6	R:R:S279	10.57	Yes	No	1	0	4
12	L:L:F6	R:R:F294	10.72	Yes	No	0	0	4
13	L:L:F7	R:R:I195	7.54	Yes	Yes	1	0	5
14	L:L:F7	R:R:W204	16.04	Yes	Yes	1	0	3
15	L:L:F7	R:R:Y205	7.22	Yes	Yes	1	0	4
16	L:L:K9	L:L:W8	10.44	Yes	Yes	1	0	0
17	L:L:W8	R:R:Q126	9.86	Yes	No	0	0	7
18	L:L:W8	R:R:I177	3.52	Yes	No	1	0	3
19	L:L:W8	R:R:I195	3.52	Yes	Yes	1	0	5
20	L:L:W8	R:R:F208	4.01	Yes	Yes	1	0	7
21	L:L:W8	R:R:T212	7.28	Yes	Yes	1	0	4
22	L:L:K9	R:R:D122	9.68	Yes	Yes	1	0	6
23	L:L:K9	R:R:V298	4.55	Yes	No	0	0	6
24	L:L:K9	R:R:Y302	5.97	Yes	Yes	1	0	7
25	L:L:T10	L:L:T12	6.28	No	Yes	1	0	0
26	L:L:T10	R:R:T194	6.28	No	Yes	1	0	4
27	L:L:F11	R:R:K291	7.44	Yes	Yes	2	0	3
28	L:L:F11	R:R:F294	16.08	Yes	No	0	0	4
29	L:L:F11	R:R:D295	3.58	Yes	Yes	2	0	2
30	L:L:S13	L:L:T12	4.8	No	Yes	0	0	0
31	L:L:T12	R:R:S192	4.8	Yes	No	1	0	4
32	L:L:T12	R:R:T194	9.42	Yes	Yes	1	0	4
33	L:L:S13	R:R:Q187	7.22	No	No	0	0	2
34	L:L:C14	R:R:P286	7.53	No	No	2	0	2
35	R:R:P288	R:R:S42	3.56	No	No	0	3	4
36	R:R:K291	R:R:N43	15.39	Yes	No	0	3	3
37	R:R:D295	R:R:L46	14.93	Yes	No	2	2	5
38	R:R:F296	R:R:L46	14.61	Yes	No	2	5	5
39	R:R:T47	R:R:V103	3.17	No	No	0	5	4
40	R:R:A104	R:R:T47	5.03	No	No	0	5	5
41	R:R:F296	R:R:I49	3.77	Yes	No	0	5	5
42	R:R:I49	R:R:V299	6.14	No	No	0	5	5
43	R:R:V103	R:R:Y50	10.09	No	No	2	4	7
44	R:R:D295	R:R:Y50	3.45	Yes	No	2	2	7
45	R:R:V299	R:R:Y50	16.4	No	No	0	5	7
46	R:R:F51	R:R:P97	5.78	No	No	0	5	8
47	R:R:A100	R:R:F51	4.16	No	No	0	6	5
48	R:R:C54	R:R:L96	6.35	No	No	1	6	7
49	R:R:C54	R:R:P97	3.77	No	No	1	6	8
50	R:R:G57	R:R:M93	3.49	No	No	0	8	6
51	R:R:C306	R:R:G57	3.92	No	No	0	8	8
52	R:R:E90	R:R:L58	6.63	Yes	No	0	7	6
53	R:R:D89	R:R:N61	16.16	Yes	No	0	9	9
54	R:R:N61	R:R:P309	13.03	No	No	0	9	9
55	R:R:E90	R:R:T62	7.06	Yes	No	0	7	5
56	R:R:F323	R:R:L63	14.61	No	No	0	6	6
57	R:R:A313	R:R:V64	3.39	No	No	3	7	9
58	R:R:F319	R:R:V64	6.55	Yes	No	3	8	9
59	R:R:A86	R:R:I65	3.25	No	No	0	9	7
60	R:R:E90	R:R:I65	5.47	Yes	No	0	7	7
61	R:R:V67	R:R:Y71	5.05	Yes	Yes	0	7	6
62	R:R:F319	R:R:V67	10.49	Yes	Yes	3	8	7
63	R:R:F323	R:R:V67	10.49	No	Yes	3	6	7
64	R:R:I68	R:R:N79	9.91	No	No	0	7	8
65	R:R:I68	R:R:L83	5.71	No	No	0	7	6
66	R:R:F319	R:R:I68	5.02	Yes	No	0	8	7
67	R:R:R70	R:R:Y71	4.12	No	Yes	0	4	6
68	R:R:S322	R:R:Y71	3.82	No	Yes	0	5	6
69	R:R:V326	R:R:Y71	8.83	No	Yes	0	5	6
70	R:R:N79	R:R:T76	4.39	No	No	0	8	7
71	R:R:I77	R:R:Y81	4.84	Yes	Yes	5	4	7
72	R:R:D139	R:R:I77	5.6	No	Yes	5	8	4
73	R:R:I77	R:R:R154	3.76	Yes	No	5	4	5
74	R:R:I77	R:R:P156	5.08	Yes	No	0	4	3
75	R:R:A159	R:R:I80	3.25	No	No	0	7	5
76	R:R:I80	R:R:K160	4.36	No	No	0	5	1
77	R:R:M136	R:R:Y81	7.18	No	Yes	0	9	7
78	R:R:D139	R:R:Y81	9.2	No	Yes	5	8	7
79	R:R:A159	R:R:Y81	4	No	Yes	0	7	7
80	R:R:I162	R:R:Y81	7.25	No	Yes	0	5	7
81	R:R:C132	R:R:N84	4.72	No	Yes	0	8	9
82	R:R:N84	R:R:T163	7.31	Yes	No	0	9	7
83	R:R:N84	R:R:W167	11.3	Yes	Yes	0	9	9
84	R:R:C132	R:R:L85	6.35	No	Yes	0	8	9
85	R:R:L133	R:R:L85	4.15	Yes	Yes	1	9	9
86	R:R:L85	R:R:M136	4.24	Yes	No	0	9	9
87	R:R:L85	R:R:N308	6.87	Yes	Yes	1	9	9
88	R:R:D89	R:R:S129	4.42	Yes	No	1	9	9
89	R:R:D89	R:R:S305	11.78	Yes	No	1	9	8
90	R:R:D89	R:R:N308	4.04	Yes	Yes	1	9	9
91	R:R:E90	R:R:L91	5.3	Yes	Yes	0	7	7
92	R:R:L91	R:R:N125	6.87	Yes	Yes	0	7	7
93	R:R:D122	R:R:F92	8.36	Yes	Yes	1	6	6
94	R:R:F92	R:R:N125	6.04	Yes	Yes	0	6	7
95	R:R:F92	R:R:Y302	19.6	Yes	Yes	1	6	7
96	R:R:F92	R:R:S305	5.28	Yes	No	1	6	8
97	R:R:D122	R:R:G95	5.03	Yes	No	0	6	6
98	R:R:L96	R:R:P97	3.28	No	No	1	7	8
99	R:R:L96	R:R:Y302	21.1	No	Yes	1	7	7
100	R:R:F98	R:R:W108	4.01	No	Yes	0	5	8
101	R:R:F98	R:R:V118	10.49	No	No	0	5	5
102	R:R:M101	R:R:W108	8.14	No	Yes	4	5	8
103	R:R:M101	R:R:P109	5.03	No	No	4	5	4
104	R:R:Q102	R:R:W108	3.29	No	Yes	0	5	8
105	R:R:D295	R:R:V103	4.38	Yes	No	2	2	4
106	R:R:H107	R:R:L105	10.29	No	No	0	4	5
107	R:R:P109	R:R:W108	25.67	No	Yes	4	4	8
108	R:R:F110	R:R:W108	9.02	No	Yes	0	6	8
109	R:R:C115	R:R:W108	6.53	No	Yes	4	9	8
110	R:R:C193	R:R:W108	6.53	No	Yes	4	9	8
111	R:R:F110	R:R:I114	22.61	No	No	0	6	6
112	R:R:C115	R:R:G111	3.92	No	No	0	9	7
113	R:R:C115	R:R:C193	7.28	No	No	4	9	9
114	R:R:A181	R:R:R116	5.53	No	No	0	4	6
115	R:R:T120	R:R:V117	3.17	No	No	0	6	5
116	R:R:M178	R:R:T120	4.52	No	No	0	5	6
117	R:R:D122	R:R:Y302	11.49	Yes	Yes	1	6	7
118	R:R:G123	R:R:I174	3.53	No	No	0	4	7
119	R:R:I124	R:R:N125	5.66	No	Yes	0	5	7
120	R:R:N125	R:R:W167	6.78	Yes	Yes	0	7	9
121	R:R:F127	R:R:Q126	9.37	Yes	No	0	6	7
122	R:R:Q126	R:R:W269	10.95	No	Yes	0	7	8
123	R:R:F127	R:R:V173	6.55	Yes	No	0	6	4
124	R:R:F127	R:R:T212	6.49	Yes	Yes	0	6	4
125	R:R:F127	R:R:G216	4.52	Yes	No	0	6	6
126	R:R:T128	R:R:W167	16.98	No	Yes	0	7	9
127	R:R:S170	R:R:T128	6.4	No	No	0	7	7
128	R:R:S129	R:R:S305	3.26	No	No	1	9	8
129	R:R:F265	R:R:I130	5.02	Yes	No	0	9	8
130	R:R:I130	R:R:W269	3.52	No	Yes	0	8	8
131	R:R:I224	R:R:L133	4.28	No	Yes	0	7	9
132	R:R:L133	R:R:N308	4.12	Yes	Yes	1	9	9
133	R:R:L133	R:R:Y312	5.86	Yes	Yes	0	9	9
134	R:R:I223	R:R:T134	4.56	No	No	0	6	7
135	R:R:I224	R:R:T134	4.56	No	No	0	7	7
136	R:R:M136	R:R:Y312	3.59	No	Yes	0	9	9
137	R:R:I224	R:R:S137	6.19	No	No	0	7	9
138	R:R:C227	R:R:S137	3.44	No	No	0	7	9
139	R:R:S137	R:R:Y228	5.09	No	Yes	0	9	9
140	R:R:C227	R:R:I138	3.27	No	No	0	7	6
141	R:R:D139	R:R:R154	9.53	No	No	5	8	5
142	R:R:R140	R:R:Y228	10.29	No	Yes	0	9	9
143	R:R:R140	R:R:Y312	9.26	No	Yes	0	9	9
144	R:R:L142	R:R:Y141	3.52	No	Yes	0	4	8
145	R:R:V145	R:R:Y141	15.14	No	Yes	6	7	8
146	R:R:H146	R:R:Y141	8.71	No	Yes	6	5	8
147	R:R:C227	R:R:Y141	5.38	No	Yes	0	7	8
148	R:R:F230	R:R:Y141	7.22	No	Yes	0	4	8
149	R:R:L142	R:R:S150	4.5	No	No	0	4	5
150	R:R:A143	R:R:R154	5.53	No	No	0	8	5
151	R:R:I231	R:R:V144	4.61	No	No	0	9	8
152	R:R:H146	R:R:V145	5.54	No	No	6	5	7
153	R:R:K234	R:R:V145	4.55	No	No	0	5	7
154	R:R:I148	R:R:P147	3.39	No	No	0	5	8
155	R:R:R155	R:R:R157	7.46	No	No	0	6	4
156	R:R:V173	R:R:Y211	6.31	No	No	0	4	4
157	R:R:I174	R:R:M178	5.83	No	No	0	7	5
158	R:R:L175	R:R:M178	4.24	No	No	0	4	5
159	R:R:P176	R:R:W204	5.4	No	Yes	1	8	3
160	R:R:F208	R:R:P176	4.33	Yes	No	1	7	8
161	R:R:I177	R:R:I195	4.42	No	Yes	1	3	5
162	R:R:F208	R:R:I177	5.02	Yes	No	1	7	3
163	R:R:I179	R:R:Y180	13.3	No	No	0	4	4
164	R:R:W197	R:R:Y180	15.43	Yes	No	1	5	4
165	R:R:P198	R:R:Y180	11.13	No	No	1	5	4
166	R:R:G182	R:R:N196	5.09	No	No	0	5	3
167	R:R:E200	R:R:R184	3.49	No	No	0	4	2
168	R:R:N186	R:R:Q187	10.56	No	No	0	1	2
169	R:R:S192	R:R:T194	4.8	No	Yes	1	4	4
170	R:R:I195	R:R:T194	4.56	Yes	Yes	1	5	4
171	R:R:I195	R:R:W204	10.57	Yes	Yes	1	5	3
172	R:R:P198	R:R:W197	12.16	No	Yes	1	5	5
173	R:R:S201	R:R:W197	16.06	No	Yes	1	2	5
174	R:R:W197	R:R:W204	50.61	Yes	Yes	1	5	3
175	R:R:P198	R:R:S201	5.34	No	No	1	5	2
176	R:R:F208	R:R:W204	30.07	Yes	Yes	1	7	3
177	R:R:I209	R:R:Y205	14.51	No	Yes	1	5	4
178	R:R:V277	R:R:Y205	3.79	No	Yes	0	5	4
179	R:R:S279	R:R:Y205	19.08	No	Yes	1	4	4
180	R:R:V280	R:R:Y205	12.62	No	Yes	1	4	4
181	R:R:T206	R:R:V280	3.17	No	No	0	3	4
182	R:R:F208	R:R:T212	3.89	Yes	Yes	1	7	4
183	R:R:I209	R:R:N276	4.25	No	No	1	5	6
184	R:R:L215	R:R:Y211	5.86	No	No	0	4	4
185	R:R:T212	R:R:Y273	6.24	Yes	No	1	4	7
186	R:R:F213	R:R:F217	13.93	Yes	Yes	1	5	8
187	R:R:F213	R:R:L218	8.53	Yes	No	1	5	4
188	R:R:F213	R:R:L270	8.53	Yes	Yes	1	5	5
189	R:R:F213	R:R:Y273	33.01	Yes	No	1	5	7
190	R:R:F217	R:R:L218	3.65	Yes	No	1	8	4
191	R:R:F217	R:R:L221	3.65	Yes	Yes	1	8	6
192	R:R:F217	R:R:F265	3.22	Yes	Yes	1	8	9
193	R:R:F217	R:R:I266	3.77	Yes	No	1	8	6
194	R:R:F217	R:R:L270	18.27	Yes	Yes	1	8	5
195	R:R:P220	R:R:V219	3.53	No	No	0	9	5
196	R:R:C225	R:R:L221	3.17	No	Yes	0	5	6
197	R:R:F265	R:R:L221	3.65	Yes	Yes	1	9	6
198	R:R:I266	R:R:L221	7.14	No	Yes	1	6	6
199	R:R:C225	R:R:V262	5.12	No	No	0	5	7
200	R:R:F230	R:R:L226	3.65	No	No	0	4	5
201	R:R:V258	R:R:Y228	8.83	No	Yes	0	8	9
202	R:R:I232	R:R:T255	6.08	No	Yes	0	5	7
203	R:R:E251	R:R:K236	14.85	No	No	0	6	4
204	R:R:R241	R:R:S237	3.95	No	No	0	1	5
205	R:R:I240	R:R:R241	6.26	No	No	0	3	1
206	R:R:I240	R:R:K248	15.99	No	No	0	3	3
207	R:R:K249	R:R:R247	3.71	No	No	0	4	4
208	R:R:R247	R:R:S250	7.91	No	No	0	4	5
209	R:R:I260	R:R:L311	4.28	No	No	0	6	8
210	R:R:L311	R:R:V261	4.47	No	No	0	8	8
211	R:R:V261	R:R:Y312	3.79	No	Yes	0	8	9
212	R:R:F265	R:R:N304	4.83	Yes	Yes	0	9	9
213	R:R:F272	R:R:W269	4.01	Yes	Yes	1	6	8
214	R:R:T301	R:R:W269	13.34	No	Yes	1	7	8
215	R:R:N304	R:R:W269	6.78	Yes	Yes	0	9	8
216	R:R:L270	R:R:Y273	7.03	Yes	No	1	5	7
217	R:R:I274	R:R:L270	5.71	No	Yes	0	5	5
218	R:R:L300	R:R:P271	4.93	No	No	0	7	9
219	R:R:F272	R:R:N276	15.71	Yes	No	1	6	6
220	R:R:F272	R:R:V298	5.24	Yes	No	0	6	6
221	R:R:F272	R:R:T301	7.78	Yes	No	1	6	7
222	R:R:F275	R:R:I274	5.02	Yes	No	0	4	5
223	R:R:F275	R:R:F294	4.29	Yes	No	0	4	4
224	R:R:F275	R:R:V297	13.11	Yes	No	0	4	7
225	R:R:S279	R:R:V280	3.23	No	No	1	4	4
226	R:R:I284	R:R:L290	4.28	No	No	0	1	4
227	R:R:P288	R:R:T287	5.25	No	No	0	3	1
228	R:R:G292	R:R:K291	3.49	No	Yes	2	1	3
229	R:R:D295	R:R:K291	4.15	Yes	Yes	2	2	3
230	R:R:D295	R:R:G292	5.03	Yes	No	2	2	1
231	R:R:D295	R:R:F296	7.17	Yes	Yes	2	2	5
232	R:R:N304	R:R:N308	6.81	Yes	Yes	0	9	9
233	R:R:A313	R:R:F319	5.55	No	Yes	3	7	8
234	R:R:F314	R:R:Q324	15.23	No	No	0	7	4
235	R:R:D317	R:R:N318	4.04	No	No	0	5	5
236	R:R:K321	R:R:N318	6.99	No	No	0	5	5
237	R:R:F319	R:R:S322	5.28	Yes	No	0	8	5
238	R:R:F319	R:R:F323	3.22	Yes	No	3	8	6
239	R:R:K320	R:R:Q324	4.07	No	No	0	8	4
240	R:R:N325	R:R:V326	4.43	No	No	0	4	5
241	R:R:C268	R:R:N304	3.15	No	Yes	0	8	9
242	R:R:I55	R:R:V52	3.07	No	No	0	4	5
243	R:R:I82	R:R:V64	3.07	No	No	0	8	9
244	R:R:I162	R:R:V135	3.07	No	No	0	5	7
245	R:R:I260	R:R:V264	3.07	No	No	0	6	7
246	R:R:K234	R:R:S238	3.06	No	No	0	5	5
247	R:R:F98	R:R:G95	3.01	No	No	0	5	6
248	R:R:N43	R:R:S42	2.98	No	No	0	3	4
249	R:R:N84	R:R:V166	2.96	Yes	No	0	9	6
250	R:R:I124	R:R:I174	2.94	No	No	0	5	7
251	R:R:F131	R:R:P220	2.89	No	No	0	6	9
252	L:L:K9	R:R:M119	2.88	Yes	No	1	0	5
253	R:R:Q102	R:R:V106	2.87	No	No	0	5	4
254	R:R:K249	R:R:K252	2.87	No	No	0	4	5
255	R:R:I87	R:R:L83	2.85	No	No	0	7	6
256	R:R:I87	R:R:L91	2.85	No	Yes	0	7	7
257	R:R:I124	R:R:L171	2.85	No	No	0	5	3
258	R:R:D89	R:R:M93	2.77	Yes	No	0	9	6
259	R:R:L91	R:R:L94	2.77	Yes	No	0	7	5
260	R:R:D317	R:R:K320	2.77	No	No	0	5	8
261	L:L:K4	R:R:E200	2.7	No	No	0	0	4
262	R:R:E251	R:R:K248	2.7	No	No	0	6	3
263	R:R:R190	R:R:V106	2.62	No	No	0	1	4
264	R:R:A88	R:R:W167	2.59	No	Yes	0	8	9
265	R:R:F230	R:R:I233	2.51	No	No	0	4	3
266	R:R:F267	R:R:L300	2.44	No	No	0	6	7
267	R:R:I231	R:R:Y228	2.42	No	Yes	0	9	9
268	R:R:N196	R:R:R184	2.41	No	No	0	3	2
269	R:R:F127	R:R:F131	2.14	Yes	No	0	6	6
270	R:R:C59	R:R:G60	1.96	No	No	0	5	8
271	R:R:G239	R:R:S238	1.86	No	No	0	5	5
272	R:R:G239	R:R:S245	1.86	No	No	0	5	2
273	R:R:A303	R:R:C268	1.81	No	No	0	5	8
274	R:R:P286	R:R:S285	1.78	No	No	0	2	2
275	R:R:P271	R:R:V297	1.77	No	No	0	9	7
276	R:R:G57	R:R:I56	1.76	No	No	0	8	4
277	R:R:G207	R:R:I210	1.76	No	No	0	4	5
278	R:R:C306	R:R:V53	1.71	No	No	0	8	7
279	R:R:G60	R:R:L63	1.71	No	No	0	8	6
280	R:R:G111	R:R:L183	1.71	No	No	0	7	4
281	R:R:I310	R:R:P309	1.69	No	No	0	6	9
282	R:R:A289	R:R:T287	1.68	No	No	0	1	1
283	R:R:E200	R:R:G202	1.64	No	No	0	4	2
284	R:R:S185	R:R:S191	1.63	No	No	0	2	5
285	R:R:S185	R:R:S192	1.63	No	No	0	2	4
286	R:R:S278	R:R:S281	1.63	No	No	0	4	4
287	R:R:A263	R:R:I260	1.62	No	No	0	5	6
288	R:R:A72	R:R:K73	1.61	No	No	0	5	5
289	R:R:A165	R:R:M164	1.61	No	No	0	4	4
290	R:R:V144	R:R:V235	1.6	No	No	0	8	8
291	R:R:V169	R:R:V173	1.6	No	No	0	4	4
292	R:R:V235	R:R:V254	1.6	No	No	0	8	8
293	R:R:T255	R:R:V254	1.59	Yes	No	0	7	8
294	R:R:A104	R:R:L105	1.58	No	No	0	5	5
295	R:R:T76	R:R:T78	1.57	No	No	0	7	8
296	R:R:I49	R:R:V52	1.54	No	No	0	5	5
297	R:R:I210	R:R:V277	1.54	No	No	0	5	5
298	R:R:H146	R:R:P147	1.53	No	No	0	5	8
299	R:R:I223	R:R:T222	1.52	No	No	0	6	4
300	R:R:M161	R:R:T158	1.51	No	No	0	1	5
301	R:R:K73	R:R:T76	1.5	No	No	0	5	7
302	R:R:G189	R:R:R190	1.5	No	No	0	6	1
303	R:R:K252	R:R:T255	1.5	No	Yes	0	5	7
304	R:R:L94	R:R:V121	1.49	No	No	0	5	5
305	R:R:P156	R:R:R155	1.44	No	No	0	3	6
306	R:R:I214	R:R:L215	1.43	No	No	0	4	4
307	R:R:E251	R:R:V235	1.43	No	No	0	6	8
308	L:L:K9	R:R:L99	1.41	Yes	No	1	0	6
309	R:R:L99	R:R:M119	1.41	No	No	1	6	5
310	R:R:L315	R:R:M257	1.41	No	No	0	6	8
311	R:R:L172	R:R:L175	1.38	No	No	0	3	4
312	R:R:F319	R:R:S316	1.32	Yes	No	0	8	8
313	R:R:R241	R:R:V242	1.31	No	No	0	1	3
314	R:R:R116	R:R:T120	1.29	No	No	0	6	6
315	R:R:R155	R:R:T158	1.29	No	No	0	6	5
316	R:R:R256	R:R:T255	1.29	No	Yes	0	6	7
317	R:R:V67	R:R:Y66	1.26	Yes	No	0	7	3
318	R:R:F314	R:R:I310	1.26	No	No	0	7	6
319	R:R:F275	R:R:M293	1.24	Yes	No	0	4	4
320	R:R:F296	R:R:M293	1.24	Yes	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:N5	7.8775	4	2	0
2	L:L:F6	10.7417	6	1	0
3	L:L:F7	9.3075	4	1	0
4	L:L:W8	6.43833	6	1	0
5	L:L:K9	5.82167	6	1	0
6	L:L:F11	9.795	4	2	0
7	L:L:T12	6.325	4	1	0
8	R:R:V67	6.8225	4	3	7
9	R:R:Y71	5.455	4	0	6
10	R:R:I77	4.82	4	5	4
11	R:R:Y81	6.494	5	5	7
12	R:R:N84	6.5725	4	0	9
13	R:R:L85	5.4025	4	1	9
14	R:R:D89	7.834	5	1	9
15	R:R:E90	6.115	4	0	7
16	R:R:L91	4.4475	4	0	7
17	R:R:F92	9.82	4	1	6
18	R:R:W108	9.02714	7	4	8
19	R:R:D122	8.64	4	1	6
20	R:R:N125	6.3375	4	0	7
21	R:R:F127	5.814	5	0	6
22	R:R:L133	4.6025	4	1	9
23	R:R:Y141	7.994	5	6	8
24	R:R:W167	9.4125	4	0	9
25	R:R:T194	6.265	4	1	4
26	R:R:I195	6.122	5	1	5
27	R:R:W197	23.565	4	1	5
28	R:R:W204	22.538	5	1	3
29	R:R:Y205	10.6257	7	1	4
30	R:R:F208	9.464	5	1	7
31	R:R:T212	5.975	4	1	4
32	R:R:F213	16	4	1	5
33	R:R:F217	7.74833	6	1	8
34	R:R:L221	4.4025	4	1	6
35	R:R:Y228	6.6575	4	0	9
36	R:R:T255	2.615	4	0	7
37	R:R:F265	4.18	4	1	9
38	R:R:W269	7.72	5	1	8
39	R:R:L270	9.885	4	1	5
40	R:R:F272	8.185	4	1	6
41	R:R:F275	5.915	4	0	4
42	R:R:K291	7.6175	4	2	3
43	R:R:D295	6.09857	7	2	2
44	R:R:F296	6.6975	4	2	5
45	R:R:Y302	14.54	4	1	7
46	R:R:N304	5.3925	4	0	9
47	R:R:N308	5.46	4	1	9
48	R:R:Y312	5.625	4	0	9
49	R:R:F319	5.34714	7	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F11	L:L:N5	15.0076	12.08	Yes	Yes	2	0	0
2	L:L:F11	R:R:F294	55.5031	16.08	Yes	No	0	0	4
3	L:L:F6	R:R:F294	68.1525	10.72	Yes	No	0	0	4
4	L:L:K4	R:R:Y205	12.3619	4.78	No	Yes	0	0	4
5	L:L:F6	L:L:F7	31.0464	6.43	Yes	Yes	1	0	0
6	L:L:F6	R:R:N276	46.0827	19.33	Yes	No	1	0	6
7	L:L:F7	R:R:I195	38.5112	7.54	Yes	Yes	1	0	5
8	L:L:W8	R:R:I195	56.337	3.52	Yes	Yes	1	0	5
9	L:L:K9	L:L:W8	74.1506	10.44	Yes	Yes	1	0	0
10	R:R:F272	R:R:N276	54.1062	15.71	Yes	No	1	6	6
11	R:R:F272	R:R:V298	29.1977	5.24	Yes	No	0	6	6
12	L:L:K9	R:R:V298	29.1977	4.55	Yes	No	0	0	6
13	L:L:W8	R:R:Q126	24.7977	9.86	Yes	No	0	0	7
14	R:R:F272	R:R:W269	33.3963	4.01	Yes	Yes	1	6	8
15	R:R:Q126	R:R:W269	23.7501	10.95	No	Yes	0	7	8
16	R:R:F208	R:R:W204	10.168	30.07	Yes	Yes	1	7	3
17	L:L:W8	R:R:T212	19.3419	7.28	Yes	Yes	1	0	4
18	R:R:F275	R:R:F294	16.3264	4.29	Yes	No	0	4	4
19	R:R:F275	R:R:I274	16.3469	5.02	Yes	No	0	4	5
20	R:R:I274	R:R:L270	17.2425	5.71	No	Yes	0	5	5
21	R:R:L270	R:R:Y273	10.9157	7.03	Yes	No	1	5	7
22	R:R:T212	R:R:Y273	13.9682	6.24	Yes	No	1	4	7
23	L:L:K9	R:R:D122	55.7948	9.68	Yes	Yes	1	0	6
24	L:L:K9	R:R:Y302	46.547	5.97	Yes	Yes	1	0	7
25	R:R:I195	R:R:T194	14.8392	4.56	Yes	Yes	1	5	4
26	L:L:F11	R:R:K291	14.5475	7.44	Yes	Yes	2	0	3
27	L:L:F11	R:R:D295	25.4632	3.58	Yes	Yes	2	0	2
28	R:R:K291	R:R:N43	10.7185	15.39	Yes	No	0	3	3
29	R:R:D295	R:R:V103	11.2526	4.38	Yes	No	2	2	4
30	R:R:F296	R:R:I49	12.0044	3.77	Yes	No	0	5	5
31	R:R:N304	R:R:W269	51.025	6.78	Yes	Yes	0	9	8
32	R:R:N304	R:R:N308	63.6786	6.81	Yes	Yes	0	9	9
33	R:R:D89	R:R:N308	42.9276	4.04	Yes	Yes	1	9	9
34	R:R:D122	R:R:F92	53.3955	8.36	Yes	Yes	1	6	6
35	R:R:F92	R:R:N125	100	6.04	Yes	Yes	0	6	7
36	R:R:L91	R:R:N125	88.7145	6.87	Yes	Yes	0	7	7
37	R:R:E90	R:R:L91	12.9247	5.3	Yes	Yes	0	7	7
38	R:R:F92	R:R:Y302	45.7294	19.6	Yes	Yes	1	6	7
39	R:R:D89	R:R:N61	13.7505	16.16	Yes	No	0	9	9
40	R:R:N61	R:R:P309	12.255	13.03	No	No	0	9	9
41	R:R:I87	R:R:L91	69.8739	2.85	No	Yes	0	7	7
42	R:R:I87	R:R:L83	67.4623	2.85	No	No	0	7	6
43	R:R:I68	R:R:L83	65.0425	5.71	No	No	0	7	6
44	R:R:F319	R:R:I68	50.343	5.02	Yes	No	0	8	7
45	R:R:F319	R:R:F323	10.0571	3.22	Yes	No	3	8	6
46	R:R:F319	R:R:V67	15.2089	10.49	Yes	Yes	3	8	7
47	R:R:V67	R:R:Y71	10.1557	5.05	Yes	Yes	0	7	6
48	R:R:F319	R:R:S322	12.9	5.28	Yes	No	0	8	5
49	R:R:S322	R:R:Y71	10.3241	3.82	No	Yes	0	5	6
50	R:R:I68	R:R:N79	13.0808	9.91	No	No	0	7	8
51	R:R:V326	R:R:Y71	10.1228	8.83	No	Yes	0	5	6
52	R:R:N79	R:R:T76	10.4803	4.39	No	No	0	8	7
53	R:R:L85	R:R:N308	16.7947	6.87	Yes	Yes	1	9	9
54	R:R:L85	R:R:M136	25.5536	4.24	Yes	No	0	9	9
55	R:R:M136	R:R:Y81	22.8668	7.18	No	Yes	0	9	7
56	R:R:I77	R:R:Y81	10.8254	4.84	Yes	Yes	5	4	7
57	R:R:C132	R:R:L85	28.7005	6.35	No	Yes	0	8	9
58	R:R:C132	R:R:N84	27.9652	4.72	No	Yes	0	8	9
59	R:R:N125	R:R:W167	31.716	6.78	Yes	Yes	0	7	9
60	R:R:L133	R:R:N308	64.7344	4.12	Yes	Yes	1	9	9
61	R:R:F92	R:R:S305	38.3468	5.28	Yes	No	1	6	8
62	R:R:D89	R:R:S305	37.0198	11.78	Yes	No	1	9	8
63	R:R:D122	R:R:G95	25.1058	5.03	Yes	No	0	6	6
64	R:R:F98	R:R:G95	23.598	3.01	No	No	0	5	6
65	R:R:F98	R:R:W108	20.5579	4.01	No	Yes	0	5	8
66	R:R:I124	R:R:N125	28.5116	5.66	No	Yes	0	5	7
67	R:R:I124	R:R:I174	23.4008	2.94	No	No	0	5	7
68	R:R:I174	R:R:M178	18.2573	5.83	No	No	0	7	5
69	R:R:M178	R:R:T120	10.4803	4.52	No	No	0	5	6
70	R:R:F127	R:R:Q126	14.4653	9.37	Yes	No	0	6	7
71	R:R:F127	R:R:T212	12.7028	6.49	Yes	Yes	0	6	4
72	R:R:F127	R:R:V173	13.0767	6.55	Yes	No	0	6	4
73	R:R:F217	R:R:L270	10.2995	18.27	Yes	Yes	1	8	5
74	R:R:F217	R:R:F265	10.7555	3.22	Yes	Yes	1	8	9
75	R:R:I224	R:R:L133	51.974	4.28	No	Yes	0	7	9
76	R:R:L133	R:R:Y312	33.5771	5.86	Yes	Yes	0	9	9
77	R:R:I224	R:R:S137	47.1098	6.19	No	No	0	7	9
78	R:R:C227	R:R:S137	25.0318	3.44	No	No	0	7	9
79	R:R:S137	R:R:Y228	26.8231	5.09	No	Yes	0	9	9
80	R:R:R140	R:R:Y312	32.9362	9.26	No	Yes	0	9	9
81	R:R:R140	R:R:Y228	31.6791	10.29	No	Yes	0	9	9
82	R:R:C227	R:R:Y141	21.9999	5.38	No	Yes	0	7	8
83	R:R:I231	R:R:Y228	49.9158	2.42	No	Yes	0	9	9
84	R:R:I231	R:R:V144	47.1591	4.61	No	No	0	9	8
85	R:R:W197	R:R:W204	13.9846	50.61	Yes	Yes	1	5	3
86	L:L:K4	R:R:E200	10.3324	2.7	No	No	0	0	4
87	R:R:V144	R:R:V235	44.5052	1.6	No	No	0	8	8
88	R:R:V235	R:R:V254	22.6408	1.6	No	No	0	8	8
89	R:R:T255	R:R:V254	20.069	1.59	Yes	No	0	7	8
90	R:R:E251	R:R:V235	19.539	1.43	No	No	0	6	8
91	R:R:E251	R:R:K248	14.1079	2.7	No	No	0	6	3
92	R:R:I240	R:R:K248	11.2485	15.99	No	No	0	3	3
93	R:R:K252	R:R:T255	11.5155	1.5	No	Yes	0	5	7
94	R:R:F275	R:R:V297	10.2831	13.11	Yes	No	0	4	7
95	R:R:I310	R:R:P309	10.7514	1.69	No	No	0	6	9
96	R:R:F275	R:R:M293	14.2763	1.24	Yes	No	0	4	4
97	R:R:F296	R:R:M293	11.9264	1.24	Yes	No	0	5	4
98	L:L:F7	R:R:Y205	10.7596	7.22	Yes	Yes	1	0	4
99	R:R:N84	R:R:W167	27.164	11.3	Yes	Yes	0	9	9
100	R:R:F265	R:R:N304	16.6427	4.83	Yes	Yes	0	9	9
101	R:R:L133	R:R:L85	17.604	4.15	Yes	Yes	1	9	9
102	R:R:M136	R:R:Y312	11.0554	3.59	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K4	R:R:Y205	4.78	0	No	Yes	0	4	0	1
L:L:N5	R:R:P286	4.89	2	Yes	No	0	2	0	1
L:L:N5	R:R:L290	8.24	2	Yes	No	0	4	0	1
L:L:F6	R:R:Y205	12.38	1	Yes	Yes	0	4	0	1
L:L:F6	R:R:I209	5.02	1	Yes	No	0	5	0	1
L:L:F6	R:R:N276	19.33	1	Yes	No	0	6	0	1
L:L:F6	R:R:S279	10.57	1	Yes	No	0	4	0	1
L:L:F6	R:R:F294	10.72	1	Yes	No	0	4	0	1
L:L:F7	R:R:I195	7.54	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:W204	16.04	1	Yes	Yes	0	3	0	1
L:L:F7	R:R:Y205	7.22	1	Yes	Yes	0	4	0	1
L:L:W8	R:R:Q126	9.86	1	Yes	No	0	7	0	1
L:L:W8	R:R:I177	3.52	1	Yes	No	0	3	0	1
L:L:W8	R:R:I195	3.52	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:F208	4.01	1	Yes	Yes	0	7	0	1
L:L:W8	R:R:T212	7.28	1	Yes	Yes	0	4	0	1
L:L:K9	R:R:D122	9.68	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:V298	4.55	1	Yes	No	0	6	0	1
L:L:K9	R:R:Y302	5.97	1	Yes	Yes	0	7	0	1
L:L:T10	R:R:T194	6.28	1	No	Yes	0	4	0	1
L:L:F11	R:R:K291	7.44	2	Yes	Yes	0	3	0	1
L:L:F11	R:R:F294	16.08	2	Yes	No	0	4	0	1
L:L:F11	R:R:D295	3.58	2	Yes	Yes	0	2	0	1
L:L:T12	R:R:S192	4.8	1	Yes	No	0	4	0	1
L:L:T12	R:R:T194	9.42	1	Yes	Yes	0	4	0	1
L:L:S13	R:R:Q187	7.22	0	No	No	0	2	0	1
L:L:C14	R:R:P286	7.53	2	No	No	0	2	0	1
R:R:K291	R:R:N43	15.39	2	Yes	No	3	3	1	2
R:R:D295	R:R:L46	14.93	2	Yes	No	2	5	1	2
R:R:F296	R:R:L46	14.61	2	Yes	No	5	5	2	2
R:R:V103	R:R:Y50	10.09	2	No	No	4	7	2	2
R:R:D295	R:R:Y50	3.45	2	Yes	No	2	7	1	2
R:R:D122	R:R:F92	8.36	1	Yes	Yes	6	6	1	2
R:R:F92	R:R:Y302	19.6	1	Yes	Yes	6	7	2	1
R:R:D122	R:R:G95	5.03	1	Yes	No	6	6	1	2
R:R:L96	R:R:Y302	21.1	1	No	Yes	7	7	2	1
R:R:D295	R:R:V103	4.38	2	Yes	No	2	4	1	2
R:R:D122	R:R:Y302	11.49	1	Yes	Yes	6	7	1	1
R:R:F127	R:R:Q126	9.37	0	Yes	No	6	7	2	1
R:R:Q126	R:R:W269	10.95	0	No	Yes	7	8	1	2
R:R:F127	R:R:T212	6.49	0	Yes	Yes	6	4	2	1
R:R:P176	R:R:W204	5.4	1	No	Yes	8	3	2	1
R:R:F208	R:R:P176	4.33	1	Yes	No	7	8	1	2
R:R:I177	R:R:I195	4.42	1	No	Yes	3	5	1	1
R:R:F208	R:R:I177	5.02	1	Yes	No	7	3	1	1
R:R:E200	R:R:R184	3.49	0	No	No	4	2	1	2
R:R:N186	R:R:Q187	10.56	0	No	No	1	2	2	1
R:R:S192	R:R:T194	4.8	1	No	Yes	4	4	1	1
R:R:I195	R:R:T194	4.56	1	Yes	Yes	5	4	1	1
R:R:I195	R:R:W204	10.57	1	Yes	Yes	5	3	1	1
R:R:W197	R:R:W204	50.61	1	Yes	Yes	5	3	2	1
R:R:F208	R:R:W204	30.07	1	Yes	Yes	7	3	1	1
R:R:I209	R:R:Y205	14.51	1	No	Yes	5	4	1	1
R:R:V277	R:R:Y205	3.79	0	No	Yes	5	4	2	1
R:R:S279	R:R:Y205	19.08	1	No	Yes	4	4	1	1
R:R:V280	R:R:Y205	12.62	1	No	Yes	4	4	2	1
R:R:F208	R:R:T212	3.89	1	Yes	Yes	7	4	1	1
R:R:I209	R:R:N276	4.25	1	No	No	5	6	1	1
R:R:T212	R:R:Y273	6.24	1	Yes	No	4	7	1	2
R:R:F272	R:R:W269	4.01	1	Yes	Yes	6	8	2	2
R:R:F272	R:R:N276	15.71	1	Yes	No	6	6	2	1
R:R:F272	R:R:V298	5.24	1	Yes	No	6	6	2	1
R:R:F275	R:R:F294	4.29	0	Yes	No	4	4	2	1
R:R:S279	R:R:V280	3.23	1	No	No	4	4	1	2
R:R:I284	R:R:L290	4.28	0	No	No	1	4	2	1
R:R:G292	R:R:K291	3.49	2	No	Yes	1	3	2	1
R:R:D295	R:R:K291	4.15	2	Yes	Yes	2	3	1	1
R:R:D295	R:R:G292	5.03	2	Yes	No	2	1	1	2
R:R:D295	R:R:F296	7.17	2	Yes	Yes	2	5	1	2
L:L:K9	R:R:M119	2.88	1	Yes	No	0	5	0	1
L:L:K4	R:R:E200	2.7	0	No	No	0	4	0	1
R:R:P286	R:R:S285	1.78	2	No	No	2	2	1	2
R:R:E200	R:R:G202	1.64	0	No	No	4	2	1	2
R:R:S185	R:R:S192	1.63	0	No	No	2	4	2	1
L:L:K9	R:R:L99	1.41	1	Yes	No	0	6	0	1
R:R:L99	R:R:M119	1.41	1	No	No	6	5	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XAT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	272
Number of Links	320
Number of Hubs	49
Number of Links mediated by Hubs	175
Number of Communities	6
Number of Nodes involved in Communities	76
Number of Links involved in Communities	109

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	70392
Length Of Smallest Path	3
Average Path Length	13.4933
Length of Longest Path	27
Minimum Path Strength	1.24
Average Path Strength	7.02038
Maximum Path Strength	40.34
Minimum Path Correlation	0.7
Average Path Correlation	0.926648
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	46.7056
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.1808
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cerebellum development • metencephalon development • hindbrain development • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • signaling receptor regulator activity • receptor ligand activity • response to acid chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • regulation of biological quality • somatostatin signaling pathway • hormone-mediated signaling pathway • somatostatin receptor signaling pathway • cell-cell signaling • regulation of cell motility • regulation of locomotion • regulation of cell migration • locomotion • response to osmotic stress • hyperosmotic response • response to stress • response to abiotic stimulus • cell surface receptor signaling pathway • negative regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to steroid hormone • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient levels • response to nutrient • response to pH • response to acidic pH • digestion • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • GABA-ergic synapse • somatodendritic compartment • cell body • neuronal cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7XAT_nogp_Chain_R T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

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