psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L40	R:R:N43	2.75	No	No	0	2	3
2	R:R:I49	R:R:V45	3.07	No	No	0	5	5
3	R:R:D295	R:R:L46	4.07	No	No	0	2	5
4	R:R:F51	R:R:T47	2.59	No	No	0	5	5
5	R:R:T47	R:R:V103	1.59	No	No	0	5	4
6	R:R:A104	R:R:T47	3.36	No	No	0	5	5
7	R:R:F48	R:R:V52	3.93	No	No	0	6	5
8	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
9	R:R:V103	R:R:Y50	2.52	No	Yes	0	4	7
10	R:R:V299	R:R:Y50	3.79	No	Yes	0	5	7
11	R:R:Y302	R:R:Y50	2.98	Yes	Yes	0	7	7
12	R:R:A100	R:R:F51	4.16	No	No	0	6	5
13	R:R:I56	R:R:V52	3.07	No	No	0	4	5
14	R:R:C306	R:R:V53	3.42	Yes	No	0	8	7
15	R:R:C54	R:R:L96	1.59	No	Yes	1	6	7
16	R:R:C54	R:R:P97	1.88	No	No	1	6	8
17	R:R:C59	R:R:I55	1.64	No	No	0	5	4
18	R:R:G57	R:R:I56	1.76	Yes	No	5	8	4
19	R:R:C306	R:R:I56	4.91	Yes	No	5	8	4
20	R:R:G57	R:R:N61	1.7	Yes	Yes	0	8	9
21	R:R:G57	R:R:M93	3.49	Yes	No	5	8	6
22	R:R:C306	R:R:G57	1.96	Yes	Yes	5	8	8
23	R:R:E90	R:R:L58	5.3	No	No	0	7	6
24	R:R:C59	R:R:G60	1.96	No	No	0	5	8
25	R:R:G60	R:R:P309	4.06	No	Yes	0	8	9
26	R:R:A86	R:R:N61	1.56	No	Yes	0	9	9
27	R:R:D89	R:R:N61	6.73	No	Yes	0	9	9
28	R:R:E90	R:R:N61	3.94	No	Yes	0	7	9
29	R:R:N61	R:R:P309	6.52	Yes	Yes	0	9	9
30	R:R:E90	R:R:T62	7.06	No	No	0	7	5
31	R:R:F323	R:R:L63	2.44	Yes	No	0	6	6
32	R:R:L327	R:R:L63	4.15	No	No	0	7	6
33	R:R:I68	R:R:V64	3.07	Yes	No	0	7	9
34	R:R:A86	R:R:V64	1.7	No	No	0	9	9
35	R:R:P309	R:R:V64	1.77	Yes	No	0	9	9
36	R:R:I65	R:R:L69	2.85	No	No	0	7	3
37	R:R:I65	R:R:L83	4.28	No	No	0	7	6
38	R:R:A86	R:R:I65	3.25	No	No	0	9	7
39	R:R:R70	R:R:Y66	6.17	No	No	0	4	3
40	R:R:S322	R:R:V67	3.23	No	No	0	5	7
41	R:R:F323	R:R:V67	5.24	Yes	No	0	6	7
42	R:R:V326	R:R:V67	1.6	No	No	0	5	7
43	R:R:I68	R:R:N79	2.83	Yes	No	3	7	8
44	R:R:I68	R:R:I82	2.94	Yes	No	0	7	8
45	R:R:F319	R:R:I68	2.51	Yes	Yes	3	8	7
46	R:R:N325	R:R:Y71	5.81	No	No	0	4	6
47	R:R:V326	R:R:Y71	3.79	No	No	0	5	6
48	R:R:K73	R:R:M74	12.96	No	No	3	5	7
49	R:R:K73	R:R:N318	2.8	No	No	0	5	5
50	R:R:K73	R:R:S322	4.59	No	No	3	5	5
51	R:R:F319	R:R:M74	7.46	Yes	No	3	8	7
52	R:R:M74	R:R:S322	4.6	No	No	3	7	5
53	R:R:N79	R:R:T76	7.31	No	No	0	8	7
54	R:R:I77	R:R:R154	3.76	No	Yes	0	4	5
55	R:R:I77	R:R:P156	1.69	No	No	0	4	3
56	R:R:I82	R:R:T78	3.04	No	No	0	8	8
57	R:R:R140	R:R:T78	2.59	Yes	No	0	9	8
58	R:R:F319	R:R:N79	3.62	Yes	No	3	8	8
59	R:R:A159	R:R:I80	1.62	No	No	0	7	5
60	R:R:V135	R:R:Y81	3.79	No	Yes	0	7	7
61	R:R:M136	R:R:Y81	5.99	No	Yes	0	9	7
62	R:R:D139	R:R:Y81	4.6	No	Yes	0	8	7
63	R:R:A159	R:R:Y81	2.67	No	Yes	0	7	7
64	R:R:T163	R:R:Y81	2.5	Yes	Yes	0	7	7
65	R:R:I82	R:R:Y312	10.88	No	No	0	8	9
66	R:R:I87	R:R:L83	4.28	No	No	0	7	6
67	R:R:C132	R:R:N84	1.57	Yes	No	0	8	9
68	R:R:N84	R:R:T163	10.24	No	Yes	0	9	7
69	R:R:N84	R:R:W167	5.65	No	No	0	9	9
70	R:R:D89	R:R:L85	2.71	No	No	0	9	9
71	R:R:L85	R:R:S129	3	No	No	0	9	9
72	R:R:C132	R:R:L85	1.59	Yes	No	0	8	9
73	R:R:D89	R:R:S305	7.36	No	No	0	9	8
74	R:R:F92	R:R:V121	2.62	Yes	No	0	6	5
75	R:R:D122	R:R:F92	3.58	No	Yes	0	6	6
76	R:R:F92	R:R:N125	20.54	Yes	No	0	6	7
77	R:R:F92	R:R:Y302	8.25	Yes	Yes	0	6	7
78	R:R:M93	R:R:S305	3.07	No	No	0	6	8
79	R:R:C306	R:R:M93	1.62	Yes	No	5	8	6
80	R:R:G95	R:R:P97	2.03	No	No	0	6	8
81	R:R:L96	R:R:P97	1.64	Yes	No	1	7	8
82	R:R:L96	R:R:L99	2.77	Yes	No	1	7	6
83	R:R:L96	R:R:Y302	2.34	Yes	Yes	0	7	7
84	R:R:F98	R:R:W108	2	No	Yes	1	5	8
85	R:R:F110	R:R:F98	6.43	Yes	No	1	6	5
86	R:R:F98	R:R:I114	2.51	No	Yes	1	5	6
87	R:R:L99	R:R:V118	4.47	No	No	1	6	5
88	R:R:D122	R:R:L99	4.07	No	No	1	6	6
89	R:R:F110	R:R:M101	4.98	Yes	No	0	6	5
90	R:R:Q102	R:R:W108	6.57	No	Yes	0	5	8
91	R:R:Q102	R:R:S192	2.89	No	No	0	5	4
92	R:R:L105	R:R:P109	3.28	No	No	0	5	4
93	R:R:R190	R:R:V106	11.77	No	No	0	1	4
94	R:R:H107	R:R:P109	6.1	No	No	0	4	4
95	R:R:H107	R:R:S191	9.76	No	No	0	4	5
96	R:R:F110	R:R:W108	9.02	Yes	Yes	1	6	8
97	R:R:I114	R:R:W108	3.52	Yes	Yes	1	6	8
98	R:R:C115	R:R:W108	3.92	Yes	Yes	1	9	8
99	R:R:L183	R:R:W108	4.56	Yes	Yes	1	4	8
100	R:R:C193	R:R:W108	7.84	Yes	Yes	1	9	8
101	R:R:F110	R:R:P109	10.11	Yes	No	0	6	4
102	R:R:F110	R:R:I114	3.77	Yes	Yes	1	6	6
103	R:R:K112	R:R:R116	3.71	No	No	0	3	6
104	R:R:G182	R:R:K112	1.74	No	No	0	5	3
105	R:R:K112	R:R:L183	2.82	No	Yes	0	3	4
106	R:R:C115	R:R:M119	1.62	Yes	No	1	9	5
107	R:R:C115	R:R:G182	1.96	Yes	No	0	9	5
108	R:R:C115	R:R:L183	3.17	Yes	Yes	1	9	4
109	R:R:C115	R:R:C193	7.28	Yes	Yes	1	9	9
110	R:R:A181	R:R:R116	2.77	No	No	0	4	6
111	R:R:V117	R:R:V121	1.6	No	No	0	5	5
112	R:R:D122	R:R:V118	2.92	No	No	1	6	5
113	R:R:A181	R:R:M119	3.22	No	No	0	4	5
114	R:R:C193	R:R:M119	4.86	Yes	No	1	9	5
115	R:R:M178	R:R:T120	7.53	No	No	0	5	6
116	R:R:G123	R:R:I174	3.53	No	Yes	10	4	7
117	R:R:G123	R:R:I177	1.76	No	Yes	10	4	3
118	R:R:I124	R:R:T128	4.56	No	Yes	0	5	7
119	R:R:I124	R:R:W167	2.35	No	No	0	5	9
120	R:R:F127	R:R:Q126	5.86	No	Yes	0	6	7
121	R:R:Q126	R:R:T212	2.83	Yes	No	0	7	4
122	R:R:Q126	R:R:W269	6.57	Yes	Yes	2	7	8
123	R:R:Q126	R:R:Y273	5.64	Yes	Yes	2	7	7
124	R:R:F127	R:R:V173	3.93	No	Yes	0	6	4
125	R:R:F127	R:R:I174	5.02	No	Yes	0	6	7
126	R:R:C132	R:R:T128	1.69	Yes	Yes	9	8	7
127	R:R:T128	R:R:V166	1.59	Yes	No	9	7	6
128	R:R:S170	R:R:T128	4.8	No	Yes	0	7	7
129	R:R:F131	R:R:I130	3.77	No	No	0	6	8
130	R:R:I130	R:R:P220	5.08	No	No	0	8	9
131	R:R:F265	R:R:I130	7.54	Yes	No	0	9	8
132	R:R:C132	R:R:V166	1.71	Yes	No	9	8	6
133	R:R:F265	R:R:L133	6.09	Yes	No	0	9	9
134	R:R:P220	R:R:T134	3.5	No	No	0	9	7
135	R:R:V135	R:R:V166	1.6	No	No	0	7	6
136	R:R:I224	R:R:S137	6.19	No	No	12	7	9
137	R:R:S137	R:R:Y228	2.54	No	Yes	0	9	9
138	R:R:S137	R:R:V262	1.62	No	No	12	9	7
139	R:R:I138	R:R:I223	2.94	No	No	4	6	6
140	R:R:C227	R:R:I138	1.64	No	No	4	7	6
141	R:R:D139	R:R:R140	2.38	No	Yes	6	8	9
142	R:R:D139	R:R:R154	10.72	No	Yes	6	8	5
143	R:R:A143	R:R:R140	4.15	No	Yes	6	8	9
144	R:R:R140	R:R:R154	2.13	Yes	Yes	6	9	5
145	R:R:L251	R:R:R140	2.43	No	Yes	0	6	9
146	R:R:R140	R:R:V254	6.54	Yes	No	0	9	8
147	R:R:R140	R:R:T255	2.59	Yes	No	0	9	7
148	R:R:R140	R:R:V258	3.92	Yes	No	0	9	8
149	R:R:V145	R:R:Y141	7.57	No	Yes	4	7	8
150	R:R:H146	R:R:Y141	6.53	Yes	Yes	4	5	8
151	R:R:C227	R:R:Y141	6.72	No	Yes	4	7	8
152	R:R:F230	R:R:Y141	3.09	No	Yes	0	4	8
153	R:R:I231	R:R:Y141	2.42	No	Yes	0	9	8
154	R:R:L142	R:R:S150	4.5	No	No	0	4	5
155	R:R:A143	R:R:R154	6.91	No	Yes	6	8	5
156	R:R:V144	R:R:V145	3.21	No	No	0	8	7
157	R:R:T255	R:R:V144	1.59	No	No	0	7	8
158	R:R:H146	R:R:V145	6.92	Yes	No	4	5	7
159	R:R:H146	R:R:K149	6.55	Yes	No	0	5	4
160	R:R:H146	R:R:S150	2.79	Yes	No	0	5	5
161	R:R:I148	R:R:P147	1.69	No	No	0	5	8
162	R:R:K152	R:R:W153	10.44	No	No	0	4	3
163	R:R:K152	R:R:R155	3.71	No	No	0	4	6
164	R:R:R155	R:R:T158	7.76	No	No	0	6	5
165	R:R:K160	R:R:R157	4.95	No	No	0	1	4
166	R:R:M161	R:R:R157	3.72	No	No	0	1	4
167	R:R:V169	R:R:V173	1.6	No	Yes	0	4	4
168	R:R:I174	R:R:S170	1.55	Yes	No	0	7	7
169	R:R:V173	R:R:Y211	5.05	Yes	No	11	4	4
170	R:R:L215	R:R:V173	2.98	No	Yes	11	4	4
171	R:R:I174	R:R:I177	4.42	Yes	Yes	10	7	3
172	R:R:L175	R:R:P176	3.28	No	No	0	4	8
173	R:R:I179	R:R:L175	2.85	No	No	0	4	4
174	R:R:I177	R:R:I195	2.94	Yes	No	0	3	5
175	R:R:F208	R:R:I177	2.51	No	Yes	0	7	3
176	R:R:I179	R:R:Y180	4.84	No	No	0	4	4
177	R:R:W197	R:R:Y180	6.75	Yes	No	7	5	4
178	R:R:P198	R:R:Y180	19.47	No	No	7	5	4
179	R:R:G182	R:R:N196	1.7	No	No	0	5	3
180	R:R:C193	R:R:L183	1.59	Yes	Yes	1	9	4
181	R:R:R184	R:R:T194	3.88	No	No	0	2	4
182	R:R:N196	R:R:R184	9.64	No	No	0	3	2
183	R:R:N186	R:R:R190	3.62	No	No	0	1	1
184	R:R:R190	R:R:S192	6.59	No	No	0	1	4
185	R:R:I195	R:R:W197	8.22	No	Yes	0	5	5
186	R:R:P198	R:R:W197	2.7	No	Yes	7	5	5
187	R:R:W197	R:R:W204	9.37	Yes	No	7	5	3
188	R:R:F208	R:R:W197	7.02	No	Yes	0	7	5
189	R:R:P198	R:R:W204	10.81	No	No	7	5	3
190	R:R:I209	R:R:Y205	9.67	No	No	0	5	4
191	R:R:T206	R:R:V280	1.59	No	No	0	3	4
192	R:R:F208	R:R:T212	5.19	No	No	0	7	4
193	R:R:I209	R:R:N276	2.83	No	No	0	5	6
194	R:R:I209	R:R:V280	6.14	No	No	0	5	4
195	R:R:I210	R:R:I214	2.94	No	No	0	5	4
196	R:R:L215	R:R:Y211	5.86	No	No	11	4	4
197	R:R:F213	R:R:Y273	6.19	No	Yes	0	5	7
198	R:R:F213	R:R:V277	3.93	No	No	0	5	5
199	R:R:I214	R:R:L215	2.85	No	No	0	4	4
200	R:R:F217	R:R:L221	8.53	No	No	0	8	6
201	R:R:F217	R:R:L270	3.65	No	No	0	8	5
202	R:R:F217	R:R:Y273	12.38	No	Yes	0	8	7
203	R:R:P220	R:R:V219	3.53	No	No	0	9	5
204	R:R:I266	R:R:L221	5.71	No	No	0	6	6
205	R:R:C227	R:R:I223	1.64	No	No	4	7	6
206	R:R:I224	R:R:V262	3.07	No	No	12	7	7
207	R:R:T255	R:R:Y228	2.5	No	Yes	0	7	9
208	R:R:V258	R:R:Y228	3.79	No	Yes	0	8	9
209	R:R:S259	R:R:Y228	5.09	No	Yes	0	4	9
210	R:R:F230	R:R:L229	3.65	No	No	0	4	4
211	R:R:I232	R:R:K236	4.36	No	No	0	5	4
212	R:R:K234	R:R:V238	6.07	No	No	0	5	5
213	R:R:S237	R:R:V238	3.23	No	No	0	5	5
214	R:R:L241	R:R:V238	5.96	Yes	No	0	1	5
215	R:R:L240	R:R:R239	2.43	No	No	0	3	5
216	R:R:D248	R:R:L240	4.07	No	No	0	3	3
217	R:R:D248	R:R:L241	5.43	No	Yes	13	3	1
218	R:R:L241	R:R:L251	4.15	Yes	No	0	1	6
219	R:R:L241	R:R:R252	3.64	Yes	No	13	1	5
220	R:R:K247	R:R:S242	4.59	No	No	0	4	3
221	R:R:L251	R:R:S242	3	No	No	0	6	3
222	R:R:K247	R:R:S244	7.65	No	No	0	4	3
223	R:R:E246	R:R:R249	10.47	No	No	0	3	4
224	R:R:E246	R:R:N250	10.52	No	No	0	3	5
225	R:R:D248	R:R:R252	8.34	No	No	13	3	5
226	R:R:R249	R:R:R253	11.73	No	No	0	4	7
227	R:R:N250	R:R:R253	4.82	No	No	0	5	7
228	R:R:I260	R:R:R256	2.51	Yes	No	14	6	6
229	R:R:L315	R:R:R256	3.64	No	No	14	6	6
230	R:R:M257	R:R:Y312	2.39	No	No	0	8	9
231	R:R:L315	R:R:M257	5.65	No	No	0	6	8
232	R:R:V258	R:R:V262	1.6	No	No	0	8	7
233	R:R:I260	R:R:S259	1.55	Yes	No	0	6	4
234	R:R:I260	R:R:L315	5.71	Yes	No	14	6	6
235	R:R:N308	R:R:V261	4.43	No	No	0	9	8
236	R:R:F265	R:R:W269	13.03	Yes	Yes	2	9	8
237	R:R:F265	R:R:N304	4.83	Yes	Yes	2	9	9
238	R:R:C268	R:R:F267	2.79	No	No	0	8	6
239	R:R:C268	R:R:N304	7.87	No	Yes	0	8	9
240	R:R:F272	R:R:W269	3.01	No	Yes	2	6	8
241	R:R:W269	R:R:Y273	5.79	Yes	Yes	2	8	7
242	R:R:T301	R:R:W269	8.49	No	Yes	2	7	8
243	R:R:N304	R:R:W269	2.26	Yes	Yes	2	9	8
244	R:R:L270	R:R:P271	3.28	No	No	0	5	9
245	R:R:I274	R:R:L270	4.28	No	No	0	5	5
246	R:R:P271	R:R:V297	1.77	No	No	0	9	7
247	R:R:L300	R:R:P271	1.64	No	No	0	7	9
248	R:R:F272	R:R:N276	8.46	No	No	0	6	6
249	R:R:F272	R:R:T301	2.59	No	No	2	6	7
250	R:R:F275	R:R:M293	3.73	No	No	0	4	4
251	R:R:F275	R:R:F294	6.43	No	No	0	4	4
252	R:R:S279	R:R:V280	1.62	No	No	0	4	4
253	R:R:I284	R:R:M282	4.37	No	No	0	1	3
254	R:R:P286	R:R:S285	1.78	No	No	0	2	2
255	R:R:L290	R:R:P286	1.64	Yes	No	0	4	2
256	R:R:P288	R:R:T287	3.5	No	No	0	3	1
257	R:R:A289	R:R:T287	1.68	No	No	15	1	1
258	R:R:L290	R:R:T287	8.84	Yes	No	15	4	1
259	R:R:A289	R:R:L290	1.58	No	Yes	15	1	4
260	R:R:G292	R:R:K291	1.74	No	No	8	1	3
261	R:R:D295	R:R:K291	12.44	No	No	8	2	3
262	R:R:D295	R:R:G292	1.68	No	No	8	2	1
263	R:R:F294	R:R:V298	3.93	No	No	0	4	6
264	R:R:V297	R:R:V298	1.6	No	No	0	7	6
265	R:R:V298	R:R:Y302	6.31	No	Yes	0	6	7
266	R:R:T301	R:R:Y302	3.75	No	Yes	0	7	7
267	R:R:A307	R:R:N304	1.56	No	Yes	0	6	9
268	R:R:N308	R:R:P309	1.63	No	Yes	0	9	9
269	R:R:F319	R:R:Y312	3.09	Yes	No	0	8	9
270	R:R:A313	R:R:K320	3.21	No	No	0	7	8
271	R:R:F319	R:R:S316	7.93	Yes	No	0	8	8
272	R:R:D317	R:R:N318	9.42	No	No	0	5	5
273	R:R:F319	R:R:F323	2.14	Yes	Yes	0	8	6
274	R:R:F323	R:R:K320	3.72	Yes	No	0	6	8
275	R:R:K320	R:R:Q324	10.85	No	No	0	8	4
276	R:R:K321	R:R:Q324	5.42	No	No	0	5	4
277	R:R:I49	R:R:V53	1.54	No	No	0	5	7
278	R:R:I49	R:R:V299	1.54	No	No	0	5	5
279	R:R:I114	R:R:V118	1.54	Yes	No	1	6	5
280	R:R:I162	R:R:V135	1.54	No	No	0	5	7
281	R:R:I231	R:R:V235	1.54	No	No	0	9	8
282	R:R:I260	R:R:V264	1.54	Yes	No	0	6	7
283	R:R:H146	R:R:P147	1.53	Yes	No	0	5	8
284	R:R:M282	R:R:S278	1.53	No	No	0	3	4
285	R:R:I124	R:R:T120	1.52	No	No	0	5	6
286	R:R:I162	R:R:T158	1.52	No	No	0	5	5
287	R:R:I223	R:R:T222	1.52	No	No	0	6	4
288	R:R:M164	R:R:T163	1.51	No	Yes	0	4	7
289	R:R:K160	R:R:T163	1.5	No	Yes	0	1	7
290	R:R:L91	R:R:V121	1.49	No	No	0	7	5
291	R:R:L311	R:R:V261	1.49	No	No	0	8	8
292	R:R:L311	R:R:V264	1.49	No	No	0	8	7
293	R:R:N43	R:R:V103	1.48	No	No	0	3	4
294	R:R:G216	R:R:Y273	1.45	No	Yes	0	6	7
295	R:R:I284	R:R:L290	1.43	No	Yes	0	1	4
296	R:R:G111	R:R:W108	1.41	No	Yes	0	7	8
297	R:R:G168	R:R:W167	1.41	No	No	0	4	9
298	R:R:L171	R:R:M178	1.41	No	No	0	3	5
299	R:R:G199	R:R:W204	1.41	No	No	0	3	3
300	R:R:A313	R:R:F314	1.39	No	No	0	7	7
301	R:R:L58	R:R:L94	1.38	No	No	0	6	5
302	R:R:F296	R:R:V297	1.31	No	No	0	5	7
303	R:R:V326	R:R:Y66	1.26	No	No	0	5	3
304	R:R:F314	R:R:I310	1.26	No	No	0	7	6
305	R:R:L46	R:R:Y50	1.17	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y50	2.892	5	0	7
2	R:R:G57	2.2275	4	5	8
3	R:R:N61	4.09	5	0	9
4	R:R:I68	2.8375	4	3	7
5	R:R:Y81	3.91	5	0	7
6	R:R:F92	8.7475	4	0	6
7	R:R:L96	2.085	4	1	7
8	R:R:W108	4.855	8	1	8
9	R:R:F110	6.862	5	1	6
10	R:R:I114	2.835	4	1	6
11	R:R:C115	3.59	5	1	9
12	R:R:Q126	5.225	4	2	7
13	R:R:T128	3.16	4	9	7
14	R:R:C132	1.64	4	9	8
15	R:R:R140	3.34125	8	6	9
16	R:R:Y141	5.266	5	4	8
17	R:R:H146	4.864	5	4	5
18	R:R:R154	5.88	4	6	5
19	R:R:T163	3.9375	4	0	7
20	R:R:V173	3.39	4	11	4
21	R:R:I174	3.63	4	10	7
22	R:R:I177	2.9075	4	10	3
23	R:R:L183	3.035	4	1	4
24	R:R:C193	5.3925	4	1	9
25	R:R:W197	6.812	5	7	5
26	R:R:Y228	3.48	4	0	9
27	R:R:L241	4.795	4	13	1
28	R:R:I260	2.8275	4	14	6
29	R:R:F265	7.8725	4	2	9
30	R:R:W269	6.525	6	2	8
31	R:R:Y273	6.29	5	2	7
32	R:R:L290	3.3725	4	15	4
33	R:R:Y302	4.726	5	0	7
34	R:R:N304	4.13	4	2	9
35	R:R:C306	2.9775	4	5	8
36	R:R:P309	3.495	4	0	9
37	R:R:F319	4.45833	6	3	8
38	R:R:F323	3.385	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I49	R:R:V299	84.725	1.54	No	No	0	5	5
2	R:R:V299	R:R:Y50	83.9896	3.79	No	Yes	0	5	7
3	R:R:V103	R:R:Y50	12.0989	2.52	No	Yes	0	4	7
4	R:R:C306	R:R:V53	86.9964	3.42	Yes	No	0	8	7
5	R:R:I49	R:R:V53	86.2154	1.54	No	No	0	5	7
6	R:R:Y302	R:R:Y50	80.2083	2.98	Yes	Yes	0	7	7
7	R:R:L96	R:R:Y302	56.5246	2.34	Yes	Yes	0	7	7
8	R:R:N61	R:R:P309	61.7052	6.52	Yes	Yes	0	9	9
9	R:R:G57	R:R:N61	87.2047	1.7	Yes	Yes	0	8	9
10	R:R:C306	R:R:G57	80.4556	1.96	Yes	Yes	5	8	8
11	R:R:E90	R:R:N61	10.0944	3.94	No	Yes	0	7	9
12	R:R:A86	R:R:N61	54.2922	1.56	No	Yes	0	9	9
13	R:R:D89	R:R:N61	39.7852	6.73	No	Yes	0	9	9
14	R:R:F319	R:R:F323	53.7	2.14	Yes	Yes	0	8	6
15	R:R:F319	R:R:I68	71.8581	2.51	Yes	Yes	3	8	7
16	R:R:I68	R:R:V64	98.1972	3.07	Yes	No	0	7	9
17	R:R:A86	R:R:V64	50.3222	1.7	No	No	0	9	9
18	R:R:P309	R:R:V64	50.628	1.77	Yes	No	0	9	9
19	R:R:F323	R:R:V67	21.9785	5.24	Yes	No	0	6	7
20	R:R:V326	R:R:V67	18.3013	1.6	No	No	0	5	7
21	R:R:F319	R:R:M74	18.0605	7.46	Yes	No	3	8	7
22	R:R:I68	R:R:I82	38.861	2.94	Yes	No	0	7	8
23	R:R:K73	R:R:M74	10.8884	12.96	No	No	3	5	7
24	R:R:D139	R:R:Y81	67.823	4.6	No	Yes	0	8	7
25	R:R:V135	R:R:Y81	61.191	3.79	No	Yes	0	7	7
26	R:R:V135	R:R:V166	64.315	1.6	No	No	0	7	6
27	R:R:T128	R:R:V166	60.2083	1.59	Yes	No	9	7	6
28	R:R:S170	R:R:T128	100	4.8	No	Yes	0	7	7
29	R:R:I174	R:R:S170	99.8959	1.55	Yes	No	0	7	7
30	R:R:F127	R:R:I174	80.4816	5.02	No	Yes	0	6	7
31	R:R:F127	R:R:Q126	78.2037	5.86	No	Yes	0	6	7
32	R:R:Q126	R:R:W269	73.6479	6.57	Yes	Yes	2	7	8
33	R:R:T301	R:R:W269	71.8451	8.49	No	Yes	2	7	8
34	R:R:T301	R:R:Y302	80.7485	3.75	No	Yes	0	7	7
35	R:R:R140	R:R:T78	43.8724	2.59	Yes	No	0	9	8
36	R:R:I82	R:R:T78	44.7966	3.04	No	No	0	8	8
37	R:R:D89	R:R:L85	42.6879	2.71	No	No	0	9	9
38	R:R:C132	R:R:L85	42.4927	1.59	Yes	No	0	8	9
39	R:R:C132	R:R:N84	12.8474	1.57	Yes	No	0	8	9
40	R:R:N84	R:R:T163	13.9668	10.24	No	Yes	0	9	7
41	R:R:C132	R:R:T128	38.1191	1.69	Yes	Yes	9	8	7
42	R:R:I82	R:R:Y312	16.5506	10.88	No	No	0	8	9
43	R:R:F319	R:R:Y312	15.7956	3.09	Yes	No	0	8	9
44	R:R:I124	R:R:T128	10.2896	4.56	No	Yes	0	5	7
45	R:R:F92	R:R:Y302	57.8913	8.25	Yes	Yes	0	6	7
46	R:R:D122	R:R:F92	50.4393	3.58	No	Yes	0	6	6
47	R:R:L96	R:R:L99	50.5369	2.77	Yes	No	1	7	6
48	R:R:I114	R:R:V118	94.9105	1.54	Yes	No	1	6	5
49	R:R:L99	R:R:V118	48.988	4.47	No	No	1	6	5
50	R:R:D122	R:R:V118	48.8773	2.92	No	No	1	6	5
51	R:R:I114	R:R:W108	68.0508	3.52	Yes	Yes	1	6	8
52	R:R:F110	R:R:I114	20.3449	3.77	Yes	Yes	1	6	6
53	R:R:Q102	R:R:W108	17.7937	6.57	No	Yes	0	5	8
54	R:R:Q102	R:R:S192	14.2597	2.89	No	No	0	5	4
55	R:R:F110	R:R:P109	14.2597	10.11	Yes	No	0	6	4
56	R:R:R190	R:R:S192	10.7127	6.59	No	No	0	1	4
57	R:R:C115	R:R:W108	24.5493	3.92	Yes	Yes	1	9	8
58	R:R:L183	R:R:W108	10.5174	4.56	Yes	Yes	1	4	8
59	R:R:C193	R:R:W108	10.5044	7.84	Yes	Yes	1	9	8
60	R:R:C115	R:R:G182	14.1751	1.96	Yes	No	0	9	5
61	R:R:I174	R:R:I177	24.0742	4.42	Yes	Yes	10	7	3
62	R:R:F208	R:R:I177	12.8539	2.51	No	Yes	0	7	3
63	R:R:F208	R:R:T212	11.2854	5.19	No	No	0	7	4
64	R:R:Q126	R:R:T212	11.9492	2.83	Yes	No	0	7	4
65	R:R:F127	R:R:V173	12.5155	3.93	No	Yes	0	6	4
66	R:R:F265	R:R:I130	12.3267	7.54	Yes	No	0	9	8
67	R:R:F265	R:R:W269	16.9867	13.03	Yes	Yes	2	9	8
68	R:R:R140	R:R:V258	15.711	3.92	Yes	No	0	9	8
69	R:R:R140	R:R:T255	44.7185	2.59	Yes	No	0	9	7
70	R:R:N308	R:R:P309	10.4198	1.63	No	Yes	0	9	9
71	R:R:V145	R:R:Y141	19.7917	7.57	No	Yes	4	7	8
72	R:R:V144	R:R:V145	35.0862	3.21	No	No	0	8	7
73	R:R:T255	R:R:V144	37.1494	1.59	No	No	0	7	8
74	R:R:L251	R:R:R140	26.9183	2.43	No	Yes	0	6	9
75	R:R:H146	R:R:V145	13.1923	6.92	Yes	No	4	5	7
76	R:R:I162	R:R:V135	10.6346	1.54	No	No	0	5	7
77	R:R:W197	R:R:Y180	12.8018	6.75	Yes	No	7	5	4
78	R:R:F208	R:R:W197	16.9802	7.02	No	Yes	0	7	5
79	R:R:I177	R:R:I195	11.8842	2.94	Yes	No	0	3	5
80	R:R:G182	R:R:N196	10.7127	1.7	No	No	0	5	3
81	R:R:I209	R:R:N276	10.4523	2.83	No	No	0	5	6
82	R:R:F272	R:R:N276	12.548	8.46	No	No	0	6	6
83	R:R:F217	R:R:Y273	11.5262	12.38	No	Yes	0	8	7
84	R:R:V298	R:R:Y302	16.5636	6.31	No	Yes	0	6	7
85	R:R:L241	R:R:L251	18.2428	4.15	Yes	No	0	1	6
86	R:R:A313	R:R:K320	11.0836	3.21	No	No	0	7	8
87	R:R:F323	R:R:K320	22.0566	3.72	Yes	No	0	6	8
88	R:R:T163	R:R:Y81	10.615	2.5	Yes	Yes	0	7	7
89	R:R:D139	R:R:R140	62.356	2.38	No	Yes	6	8	9
90	R:R:Q126	R:R:Y273	13.2899	5.64	Yes	Yes	2	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7UL5

PDB Summary
PDB	7UL5
Class	A
SubFamily	Peptide
Type	Somatostatin
SubType	SST2
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.1
Date	2022-06-29
D.O.I.	10.1038/s41594-022-00859-8

Net Summary
I_min	1.55
Number of Linked Nodes	259
Number of Links	305
Number of Hubs	38
Number of Links mediated by Hubs	146
Number of Communities	15
Number of Nodes involved in Communities	69
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	51004
Length Of Smallest Path	3
Average Path Length	13.8733
Length of Longest Path	30
Minimum Path Strength	1.325
Average Path Strength	3.79142
Maximum Path Strength	15.14
Minimum Path Correlation	0.7
Average Path Correlation	0.922547
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	46.0738
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.3871
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7UL5_Chain_R L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N G R S S C T I N W P G G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S V R L L S G S R E K D R N L R R V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/&β;1/&γ;2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/&β;1/&γ;2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/&β;1/&γ;2	3.72	2022-07-13	10.7554/eLife.76823
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/&β;1/&γ;2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/&β;1/&γ;2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/&β;1/&γ;2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/&β;1/&γ;2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/&β;1/&γ;2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/&β;1/&γ;2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/&β;1/&γ;2	3.37	2023-04-19	10.1038/s41467-023-36673-z

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