psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L40	R:R:N43	2.75	No	No	0	2	3
2	R:R:I49	R:R:V45	3.07	No	No	0	5	5
3	R:R:D295	R:R:L46	4.07	No	No	0	2	5
4	R:R:F51	R:R:T47	2.59	No	No	0	5	5
5	R:R:T47	R:R:V103	1.59	No	No	0	5	4
6	R:R:A104	R:R:T47	3.36	No	No	0	5	5
7	R:R:F48	R:R:V52	3.93	No	No	0	6	5
8	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
9	R:R:V103	R:R:Y50	2.52	No	Yes	0	4	7
10	R:R:V299	R:R:Y50	3.79	No	Yes	0	5	7
11	R:R:Y302	R:R:Y50	2.98	Yes	Yes	0	7	7
12	R:R:A100	R:R:F51	4.16	No	No	0	6	5
13	R:R:I56	R:R:V52	3.07	No	No	0	4	5
14	R:R:C306	R:R:V53	3.42	Yes	No	0	8	7
15	R:R:C54	R:R:L96	1.59	No	Yes	1	6	7
16	R:R:C54	R:R:P97	1.88	No	No	1	6	8
17	R:R:C59	R:R:I55	1.64	No	No	0	5	4
18	R:R:G57	R:R:I56	1.76	Yes	No	4	8	4
19	R:R:C306	R:R:I56	4.91	Yes	No	4	8	4
20	R:R:G57	R:R:N61	1.7	Yes	Yes	0	8	9
21	R:R:G57	R:R:M93	3.49	Yes	No	4	8	6
22	R:R:C306	R:R:G57	1.96	Yes	Yes	4	8	8
23	R:R:E90	R:R:L58	5.3	No	No	0	7	6
24	R:R:C59	R:R:G60	1.96	No	No	0	5	8
25	R:R:G60	R:R:P309	4.06	No	Yes	0	8	9
26	R:R:A86	R:R:N61	1.56	No	Yes	0	9	9
27	R:R:D89	R:R:N61	6.73	No	Yes	0	9	9
28	R:R:E90	R:R:N61	3.94	No	Yes	0	7	9
29	R:R:N61	R:R:P309	6.52	Yes	Yes	0	9	9
30	R:R:E90	R:R:T62	7.06	No	No	0	7	5
31	R:R:F323	R:R:L63	2.44	No	No	0	6	6
32	R:R:L327	R:R:L63	4.15	No	No	0	7	6
33	R:R:I68	R:R:V64	3.07	Yes	No	0	7	9
34	R:R:A86	R:R:V64	1.7	No	No	0	9	9
35	R:R:P309	R:R:V64	1.77	Yes	No	0	9	9
36	R:R:I65	R:R:L69	2.85	No	No	0	7	3
37	R:R:I65	R:R:L83	4.28	No	No	0	7	6
38	R:R:A86	R:R:I65	3.25	No	No	0	9	7
39	R:R:R70	R:R:Y66	14.4	No	No	0	4	3
40	R:R:S322	R:R:V67	3.23	No	No	0	5	7
41	R:R:F323	R:R:V67	5.24	No	No	0	6	7
42	R:R:V326	R:R:V67	1.6	No	No	0	5	7
43	R:R:I68	R:R:N79	2.83	Yes	No	7	7	8
44	R:R:I68	R:R:I82	2.94	Yes	No	0	7	8
45	R:R:F319	R:R:I68	2.51	Yes	Yes	7	8	7
46	R:R:N325	R:R:Y71	5.81	No	No	0	4	6
47	R:R:V326	R:R:Y71	3.79	No	No	0	5	6
48	R:R:F319	R:R:M74	7.46	Yes	No	0	8	7
49	R:R:M74	R:R:S322	4.6	No	No	0	7	5
50	R:R:N79	R:R:T76	7.31	No	No	0	8	7
51	R:R:I77	R:R:R154	3.76	No	Yes	0	4	5
52	R:R:I77	R:R:P156	1.69	No	No	0	4	3
53	R:R:I82	R:R:T78	3.04	No	No	0	8	8
54	R:R:R140	R:R:T78	2.59	Yes	No	0	9	8
55	R:R:F319	R:R:N79	3.62	Yes	No	7	8	8
56	R:R:A159	R:R:I80	1.62	No	No	0	7	5
57	R:R:V135	R:R:Y81	3.79	No	Yes	0	7	7
58	R:R:M136	R:R:Y81	5.99	No	Yes	0	9	7
59	R:R:D139	R:R:Y81	4.6	No	Yes	0	8	7
60	R:R:A159	R:R:Y81	2.67	No	Yes	0	7	7
61	R:R:T163	R:R:Y81	2.5	No	Yes	0	7	7
62	R:R:I82	R:R:Y312	10.88	No	No	0	8	9
63	R:R:I87	R:R:L83	4.28	No	No	0	7	6
64	R:R:C132	R:R:N84	1.57	Yes	No	0	8	9
65	R:R:N84	R:R:T163	10.24	No	No	0	9	7
66	R:R:N84	R:R:W167	5.65	No	No	0	9	9
67	R:R:D89	R:R:L85	2.71	No	No	0	9	9
68	R:R:L85	R:R:S129	3	No	No	0	9	9
69	R:R:C132	R:R:L85	1.59	Yes	No	0	8	9
70	R:R:D89	R:R:S305	7.36	No	No	0	9	8
71	R:R:F92	R:R:V121	2.62	Yes	No	0	6	5
72	R:R:D122	R:R:F92	3.58	No	Yes	0	6	6
73	R:R:F92	R:R:N125	20.54	Yes	No	0	6	7
74	R:R:F92	R:R:Y302	8.25	Yes	Yes	0	6	7
75	R:R:M93	R:R:S305	3.07	No	No	0	6	8
76	R:R:C306	R:R:M93	1.62	Yes	No	4	8	6
77	R:R:G95	R:R:P97	2.03	No	No	0	6	8
78	R:R:L96	R:R:P97	1.64	Yes	No	1	7	8
79	R:R:L96	R:R:L99	2.77	Yes	No	1	7	6
80	R:R:L96	R:R:Y302	2.34	Yes	Yes	0	7	7
81	R:R:F98	R:R:W108	2	No	Yes	1	5	8
82	R:R:F110	R:R:F98	6.43	Yes	No	1	6	5
83	R:R:F98	R:R:I114	2.51	No	Yes	1	5	6
84	R:R:L99	R:R:V118	4.47	No	No	1	6	5
85	R:R:D122	R:R:L99	4.07	No	No	1	6	6
86	R:R:F110	R:R:M101	4.98	Yes	No	0	6	5
87	R:R:Q102	R:R:W108	6.57	No	Yes	0	5	8
88	R:R:Q102	R:R:S192	2.89	No	No	0	5	4
89	R:R:L105	R:R:P109	3.28	No	No	0	5	4
90	R:R:R190	R:R:V106	7.85	No	No	0	1	4
91	R:R:H107	R:R:P109	6.1	No	No	0	4	4
92	R:R:H107	R:R:S191	2.79	No	No	0	4	5
93	R:R:F110	R:R:W108	9.02	Yes	Yes	1	6	8
94	R:R:I114	R:R:W108	3.52	Yes	Yes	1	6	8
95	R:R:C115	R:R:W108	3.92	Yes	Yes	1	9	8
96	R:R:L183	R:R:W108	4.56	Yes	Yes	1	4	8
97	R:R:C193	R:R:W108	7.84	Yes	Yes	1	9	8
98	R:R:F110	R:R:P109	10.11	Yes	No	0	6	4
99	R:R:F110	R:R:I114	3.77	Yes	Yes	1	6	6
100	R:R:K112	R:R:R116	3.71	No	No	0	3	6
101	R:R:G182	R:R:K112	1.74	No	No	0	5	3
102	R:R:K112	R:R:L183	2.82	No	Yes	0	3	4
103	R:R:C115	R:R:M119	1.62	Yes	No	1	9	5
104	R:R:C115	R:R:G182	1.96	Yes	No	0	9	5
105	R:R:C115	R:R:L183	3.17	Yes	Yes	1	9	4
106	R:R:C115	R:R:C193	7.28	Yes	Yes	1	9	9
107	R:R:A181	R:R:R116	2.77	No	No	0	4	6
108	R:R:V117	R:R:V121	1.6	No	No	0	5	5
109	R:R:D122	R:R:V118	2.92	No	No	1	6	5
110	R:R:A181	R:R:M119	3.22	No	No	0	4	5
111	R:R:C193	R:R:M119	4.86	Yes	No	1	9	5
112	R:R:M178	R:R:T120	7.53	No	No	0	5	6
113	R:R:G123	R:R:I174	3.53	No	Yes	9	4	7
114	R:R:G123	R:R:I177	1.76	No	Yes	9	4	3
115	R:R:I124	R:R:T128	4.56	No	Yes	0	5	7
116	R:R:I124	R:R:W167	2.35	No	No	0	5	9
117	R:R:F127	R:R:Q126	5.86	No	Yes	0	6	7
118	R:R:Q126	R:R:T212	2.83	Yes	No	0	7	4
119	R:R:Q126	R:R:W269	6.57	Yes	Yes	2	7	8
120	R:R:Q126	R:R:Y273	5.64	Yes	Yes	2	7	7
121	R:R:F127	R:R:V173	3.93	No	Yes	0	6	4
122	R:R:F127	R:R:I174	5.02	No	Yes	0	6	7
123	R:R:C132	R:R:T128	1.69	Yes	Yes	8	8	7
124	R:R:T128	R:R:V166	1.59	Yes	No	8	7	6
125	R:R:S170	R:R:T128	4.8	No	Yes	0	7	7
126	R:R:F131	R:R:I130	3.77	No	No	0	6	8
127	R:R:I130	R:R:P220	5.08	No	No	0	8	9
128	R:R:F265	R:R:I130	7.54	Yes	No	0	9	8
129	R:R:C132	R:R:V166	1.71	Yes	No	8	8	6
130	R:R:F265	R:R:L133	6.09	Yes	No	0	9	9
131	R:R:P220	R:R:T134	3.5	No	No	0	9	7
132	R:R:V135	R:R:V166	1.6	No	No	0	7	6
133	R:R:I224	R:R:S137	6.19	No	No	11	7	9
134	R:R:S137	R:R:Y228	2.54	No	Yes	0	9	9
135	R:R:S137	R:R:V262	1.62	No	No	11	9	7
136	R:R:I138	R:R:I223	2.94	No	No	3	6	6
137	R:R:C227	R:R:I138	1.64	No	No	3	7	6
138	R:R:D139	R:R:R140	2.38	No	Yes	5	8	9
139	R:R:D139	R:R:R154	10.72	No	Yes	5	8	5
140	R:R:A143	R:R:R140	4.15	No	Yes	5	8	9
141	R:R:R140	R:R:R154	2.13	Yes	Yes	5	9	5
142	R:R:L251	R:R:R140	2.43	No	Yes	0	6	9
143	R:R:R140	R:R:V254	6.54	Yes	No	0	9	8
144	R:R:R140	R:R:T255	2.59	Yes	No	0	9	7
145	R:R:R140	R:R:V258	3.92	Yes	No	0	9	8
146	R:R:V145	R:R:Y141	7.57	No	Yes	3	7	8
147	R:R:H146	R:R:Y141	6.53	Yes	Yes	3	5	8
148	R:R:C227	R:R:Y141	6.72	No	Yes	3	7	8
149	R:R:F230	R:R:Y141	3.09	No	Yes	0	4	8
150	R:R:I231	R:R:Y141	2.42	No	Yes	0	9	8
151	R:R:L142	R:R:S150	7.51	No	No	0	4	5
152	R:R:A143	R:R:R154	6.91	No	Yes	5	8	5
153	R:R:V144	R:R:V145	3.21	No	No	0	8	7
154	R:R:T255	R:R:V144	1.59	No	No	0	7	8
155	R:R:H146	R:R:V145	6.92	Yes	No	3	5	7
156	R:R:H146	R:R:K149	3.93	Yes	No	0	5	4
157	R:R:H146	R:R:S150	2.79	Yes	No	0	5	5
158	R:R:I148	R:R:K149	7.27	No	No	0	5	4
159	R:R:P156	R:R:R155	2.88	No	No	0	3	6
160	R:R:K160	R:R:T163	7.51	No	No	0	1	7
161	R:R:K160	R:R:M164	7.2	No	No	0	1	4
162	R:R:V169	R:R:V173	1.6	No	Yes	0	4	4
163	R:R:I174	R:R:S170	1.55	Yes	No	0	7	7
164	R:R:V173	R:R:Y211	5.05	Yes	No	10	4	4
165	R:R:L215	R:R:V173	2.98	No	Yes	10	4	4
166	R:R:I174	R:R:I177	4.42	Yes	Yes	9	7	3
167	R:R:L175	R:R:P176	3.28	No	No	0	4	8
168	R:R:I179	R:R:L175	2.85	No	No	0	4	4
169	R:R:I177	R:R:I195	2.94	Yes	No	0	3	5
170	R:R:F208	R:R:I177	2.51	No	Yes	0	7	3
171	R:R:I179	R:R:Y180	4.84	No	No	0	4	4
172	R:R:W197	R:R:Y180	6.75	Yes	No	6	5	4
173	R:R:P198	R:R:Y180	19.47	No	No	6	5	4
174	R:R:G182	R:R:N196	1.7	No	No	0	5	3
175	R:R:L183	R:R:S191	3	Yes	No	0	4	5
176	R:R:C193	R:R:L183	1.59	Yes	Yes	1	9	4
177	R:R:R184	R:R:T194	3.88	No	No	0	2	4
178	R:R:N196	R:R:R184	9.64	No	No	0	3	2
179	R:R:N186	R:R:R190	6.03	No	No	0	1	1
180	R:R:R190	R:R:S192	6.59	No	No	0	1	4
181	R:R:I195	R:R:W197	8.22	No	Yes	0	5	5
182	R:R:P198	R:R:W197	2.7	No	Yes	6	5	5
183	R:R:W197	R:R:W204	9.37	Yes	No	6	5	3
184	R:R:F208	R:R:W197	7.02	No	Yes	0	7	5
185	R:R:P198	R:R:W204	10.81	No	No	6	5	3
186	R:R:I209	R:R:Y205	9.67	No	No	0	5	4
187	R:R:T206	R:R:V280	1.59	No	No	0	3	4
188	R:R:F208	R:R:T212	5.19	No	No	0	7	4
189	R:R:I209	R:R:N276	2.83	No	No	0	5	6
190	R:R:I209	R:R:V280	6.14	No	No	0	5	4
191	R:R:I210	R:R:I214	2.94	No	No	0	5	4
192	R:R:L215	R:R:Y211	5.86	No	No	10	4	4
193	R:R:F213	R:R:Y273	6.19	No	Yes	0	5	7
194	R:R:F213	R:R:V277	3.93	No	No	0	5	5
195	R:R:I214	R:R:L215	2.85	No	No	0	4	4
196	R:R:F217	R:R:L221	8.53	No	No	0	8	6
197	R:R:F217	R:R:L270	3.65	No	No	0	8	5
198	R:R:F217	R:R:Y273	12.38	No	Yes	0	8	7
199	R:R:P220	R:R:V219	3.53	No	No	0	9	5
200	R:R:I266	R:R:L221	5.71	No	No	0	6	6
201	R:R:C227	R:R:I223	1.64	No	No	3	7	6
202	R:R:I224	R:R:V262	3.07	No	No	11	7	7
203	R:R:T255	R:R:Y228	2.5	No	Yes	0	7	9
204	R:R:V258	R:R:Y228	3.79	No	Yes	0	8	9
205	R:R:S259	R:R:Y228	5.09	No	Yes	0	4	9
206	R:R:F230	R:R:L229	3.65	No	No	0	4	4
207	R:R:I232	R:R:K236	4.36	No	No	0	5	4
208	R:R:K234	R:R:V238	6.07	No	No	0	5	5
209	R:R:S237	R:R:V238	1.62	No	No	0	5	5
210	R:R:L241	R:R:V238	4.47	Yes	No	0	1	5
211	R:R:L240	R:R:R239	2.43	No	No	0	3	5
212	R:R:D248	R:R:L240	4.07	No	No	0	3	3
213	R:R:D248	R:R:L241	5.43	No	Yes	12	3	1
214	R:R:L241	R:R:L251	4.15	Yes	No	0	1	6
215	R:R:L241	R:R:R252	3.64	Yes	No	12	1	5
216	R:R:K247	R:R:S242	4.59	No	No	0	4	3
217	R:R:L251	R:R:S242	3	No	No	0	6	3
218	R:R:E246	R:R:K247	4.05	No	No	0	3	4
219	R:R:D248	R:R:R252	8.34	No	No	12	3	5
220	R:R:R249	R:R:R253	11.73	No	No	0	4	7
221	R:R:N250	R:R:R253	4.82	No	No	0	5	7
222	R:R:I260	R:R:R256	2.51	Yes	No	13	6	6
223	R:R:L315	R:R:R256	3.64	No	No	13	6	6
224	R:R:M257	R:R:Y312	2.39	No	No	0	8	9
225	R:R:L315	R:R:M257	5.65	No	No	0	6	8
226	R:R:V258	R:R:V262	1.6	No	No	0	8	7
227	R:R:I260	R:R:S259	1.55	Yes	No	0	6	4
228	R:R:I260	R:R:L315	5.71	Yes	No	13	6	6
229	R:R:N308	R:R:V261	4.43	No	No	0	9	8
230	R:R:F265	R:R:W269	13.03	Yes	Yes	2	9	8
231	R:R:F265	R:R:N304	4.83	Yes	Yes	2	9	9
232	R:R:C268	R:R:F267	2.79	No	No	0	8	6
233	R:R:C268	R:R:N304	7.87	No	Yes	0	8	9
234	R:R:F272	R:R:W269	3.01	No	Yes	2	6	8
235	R:R:W269	R:R:Y273	5.79	Yes	Yes	2	8	7
236	R:R:T301	R:R:W269	8.49	No	Yes	2	7	8
237	R:R:N304	R:R:W269	2.26	Yes	Yes	2	9	8
238	R:R:L270	R:R:P271	3.28	No	No	0	5	9
239	R:R:I274	R:R:L270	4.28	No	No	0	5	5
240	R:R:P271	R:R:V297	1.77	No	No	0	9	7
241	R:R:L300	R:R:P271	1.64	No	No	0	7	9
242	R:R:F272	R:R:N276	8.46	No	No	0	6	6
243	R:R:F272	R:R:T301	2.59	No	No	2	6	7
244	R:R:I274	R:R:S278	1.55	No	No	0	5	4
245	R:R:F275	R:R:S279	5.28	No	No	0	4	4
246	R:R:F275	R:R:M293	3.73	No	No	0	4	4
247	R:R:F275	R:R:F294	6.43	No	No	0	4	4
248	R:R:M282	R:R:S278	3.07	No	No	0	3	4
249	R:R:I284	R:R:M282	4.37	No	No	0	1	3
250	R:R:P286	R:R:S285	1.78	No	No	0	2	2
251	R:R:L290	R:R:P286	1.64	No	No	0	4	2
252	R:R:P288	R:R:T287	6.99	No	No	0	3	1
253	R:R:A289	R:R:T287	1.68	No	No	0	1	1
254	R:R:L290	R:R:T287	7.37	No	No	0	4	1
255	R:R:K291	R:R:P288	1.67	No	No	0	3	3
256	R:R:G292	R:R:K291	3.49	No	No	0	1	3
257	R:R:D295	R:R:G292	1.68	No	No	0	2	1
258	R:R:F294	R:R:V298	3.93	No	No	0	4	6
259	R:R:V297	R:R:V298	1.6	No	No	0	7	6
260	R:R:V298	R:R:Y302	6.31	No	Yes	0	6	7
261	R:R:T301	R:R:Y302	3.75	No	Yes	0	7	7
262	R:R:A307	R:R:N304	1.56	No	Yes	0	6	9
263	R:R:N308	R:R:P309	1.63	No	Yes	0	9	9
264	R:R:F319	R:R:Y312	3.09	Yes	No	0	8	9
265	R:R:A313	R:R:K320	3.21	No	No	0	7	8
266	R:R:F319	R:R:S316	7.93	Yes	No	0	8	8
267	R:R:F319	R:R:F323	2.14	Yes	No	0	8	6
268	R:R:K320	R:R:Q324	2.71	No	No	0	8	4
269	R:R:I49	R:R:V53	1.54	No	No	0	5	7
270	R:R:I49	R:R:V299	1.54	No	No	0	5	5
271	R:R:I114	R:R:V118	1.54	Yes	No	1	6	5
272	R:R:I162	R:R:V135	1.54	No	No	0	5	7
273	R:R:I231	R:R:V235	1.54	No	No	0	9	8
274	R:R:I260	R:R:V264	1.54	Yes	No	0	6	7
275	R:R:H146	R:R:P147	1.53	Yes	No	0	5	8
276	R:R:K247	R:R:S244	1.53	No	No	0	4	3
277	R:R:I124	R:R:T120	1.52	No	No	0	5	6
278	R:R:I162	R:R:T158	1.52	No	No	0	5	5
279	R:R:I223	R:R:T222	1.52	No	No	0	6	4
280	R:R:L91	R:R:V121	1.49	No	No	0	7	5
281	R:R:L311	R:R:V261	1.49	No	No	0	8	8
282	R:R:L311	R:R:V264	1.49	No	No	0	8	7
283	R:R:N43	R:R:V103	1.48	No	No	0	3	4
284	R:R:G216	R:R:Y273	1.45	No	Yes	0	6	7
285	R:R:I284	R:R:L290	1.43	No	No	0	1	4
286	R:R:G111	R:R:W108	1.41	No	Yes	0	7	8
287	R:R:G168	R:R:W167	1.41	No	No	0	4	9
288	R:R:L171	R:R:M178	1.41	No	No	0	3	5
289	R:R:G199	R:R:W204	1.41	No	No	0	3	3
290	R:R:M74	R:R:N318	1.4	No	No	0	7	5
291	R:R:A313	R:R:F314	1.39	No	No	0	7	7
292	R:R:L58	R:R:L94	1.38	No	No	0	6	5
293	R:R:D317	R:R:K321	1.38	No	No	0	5	5
294	R:R:K321	R:R:Q324	1.36	No	No	0	5	4
295	R:R:F296	R:R:V297	1.31	No	No	0	5	7
296	R:R:V326	R:R:Y66	1.26	No	No	0	5	3
297	R:R:F314	R:R:I310	1.26	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y50	3.3225	4	0	7
2	R:R:G57	2.2275	4	4	8
3	R:R:N61	4.09	5	0	9
4	R:R:I68	2.8375	4	7	7
5	R:R:Y81	3.91	5	0	7
6	R:R:F92	8.7475	4	0	6
7	R:R:L96	2.085	4	1	7
8	R:R:W108	4.855	8	1	8
9	R:R:F110	6.862	5	1	6
10	R:R:I114	2.835	4	1	6
11	R:R:C115	3.59	5	1	9
12	R:R:Q126	5.225	4	2	7
13	R:R:T128	3.16	4	8	7
14	R:R:C132	1.64	4	8	8
15	R:R:R140	3.34125	8	5	9
16	R:R:Y141	5.266	5	3	8
17	R:R:H146	4.34	5	3	5
18	R:R:R154	5.88	4	5	5
19	R:R:V173	3.39	4	10	4
20	R:R:I174	3.63	4	9	7
21	R:R:I177	2.9075	4	9	3
22	R:R:L183	3.028	5	1	4
23	R:R:C193	5.3925	4	1	9
24	R:R:W197	6.812	5	6	5
25	R:R:Y228	3.48	4	0	9
26	R:R:L241	4.4225	4	12	1
27	R:R:I260	2.8275	4	13	6
28	R:R:F265	7.8725	4	2	9
29	R:R:W269	6.525	6	2	8
30	R:R:Y273	6.29	5	2	7
31	R:R:Y302	4.726	5	0	7
32	R:R:N304	4.13	4	2	9
33	R:R:C306	2.9775	4	4	8
34	R:R:P309	3.495	4	0	9
35	R:R:F319	4.45833	6	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I49	R:R:V299	71.7673	1.54	No	No	0	5	5
2	R:R:V299	R:R:Y50	71.2524	3.79	No	Yes	0	5	7
3	R:R:V103	R:R:Y50	11.4622	2.52	No	Yes	0	4	7
4	R:R:P288	R:R:T287	11.068	6.99	No	No	0	3	1
5	R:R:L290	R:R:T287	15.4673	7.37	No	No	0	4	1
6	R:R:I284	R:R:L290	21.8245	1.43	No	No	0	1	4
7	R:R:I284	R:R:M282	23.9733	4.37	No	No	0	1	3
8	R:R:M282	R:R:S278	26.103	3.07	No	No	0	3	4
9	R:R:I274	R:R:S278	28.22	1.55	No	No	0	5	4
10	R:R:I274	R:R:L270	30.3242	4.28	No	No	0	5	5
11	R:R:L270	R:R:P271	17.3872	3.28	No	No	0	5	9
12	R:R:P271	R:R:V297	17.8449	1.77	No	No	0	9	7
13	R:R:V297	R:R:V298	19.9936	1.6	No	No	0	7	6
14	R:R:V298	R:R:Y302	28.2962	6.31	No	Yes	0	6	7
15	R:R:Y302	R:R:Y50	70.0064	2.98	Yes	Yes	0	7	7
16	R:R:C306	R:R:V53	73.3948	3.42	Yes	No	0	8	7
17	R:R:I49	R:R:V53	72.829	1.54	No	No	0	5	7
18	R:R:L96	R:R:Y302	53.0388	2.34	Yes	Yes	0	7	7
19	R:R:N61	R:R:P309	52.6955	6.52	Yes	Yes	0	9	9
20	R:R:G57	R:R:N61	73.0451	1.7	Yes	Yes	0	8	9
21	R:R:C306	R:R:G57	67.0184	1.96	Yes	Yes	4	8	8
22	R:R:A86	R:R:N61	45.2448	1.56	No	Yes	0	9	9
23	R:R:D89	R:R:N61	35.3083	6.73	No	Yes	0	9	9
24	R:R:F319	R:R:F323	33.5346	2.14	Yes	No	0	8	6
25	R:R:F319	R:R:I68	49.8983	2.51	Yes	Yes	7	8	7
26	R:R:I68	R:R:V64	78.4997	3.07	Yes	No	0	7	9
27	R:R:A86	R:R:V64	40.6357	1.7	No	No	0	9	9
28	R:R:P309	R:R:V64	40.8392	1.77	Yes	No	0	9	9
29	R:R:F323	R:R:V67	22.4793	5.24	No	No	0	6	7
30	R:R:V326	R:R:V67	18.8303	1.6	No	No	0	5	7
31	R:R:F319	R:R:M74	11.2079	7.46	Yes	No	0	8	7
32	R:R:I68	R:R:I82	32.6383	2.94	Yes	No	0	7	8
33	R:R:D139	R:R:Y81	68.3026	4.6	No	Yes	0	8	7
34	R:R:V135	R:R:Y81	63.9479	3.79	No	Yes	0	7	7
35	R:R:V135	R:R:V166	65.9504	1.6	No	No	0	7	6
36	R:R:T128	R:R:V166	62.8481	1.59	Yes	No	8	7	6
37	R:R:S170	R:R:T128	99.9237	4.8	No	Yes	0	7	7
38	R:R:I174	R:R:S170	100	1.55	Yes	No	0	7	7
39	R:R:F127	R:R:I174	83.9224	5.02	No	Yes	0	6	7
40	R:R:F127	R:R:Q126	82.9371	5.86	No	Yes	0	6	7
41	R:R:Q126	R:R:W269	67.2282	6.57	Yes	Yes	2	7	8
42	R:R:T301	R:R:W269	66.2301	8.49	No	Yes	2	7	8
43	R:R:T301	R:R:Y302	72.829	3.75	No	Yes	0	7	7
44	R:R:R140	R:R:T78	34.5963	2.59	Yes	No	0	9	8
45	R:R:I82	R:R:T78	35.302	3.04	No	No	0	8	8
46	R:R:D89	R:R:L85	37.9911	2.71	No	No	0	9	9
47	R:R:C132	R:R:L85	38.2327	1.59	Yes	No	0	8	9
48	R:R:N84	R:R:T163	10.5976	10.24	No	No	0	9	7
49	R:R:C132	R:R:T128	34.4501	1.69	Yes	Yes	8	8	7
50	R:R:I82	R:R:Y312	12.5556	10.88	No	No	0	8	9
51	R:R:F319	R:R:Y312	11.157	3.09	Yes	No	0	8	9
52	R:R:F92	R:R:Y302	54.2975	8.25	Yes	Yes	0	6	7
53	R:R:D122	R:R:F92	47.3363	3.58	No	Yes	0	6	6
54	R:R:L96	R:R:L99	47.4444	2.77	Yes	No	1	7	6
55	R:R:I114	R:R:V118	89.1227	1.54	Yes	No	1	6	5
56	R:R:L99	R:R:V118	45.9949	4.47	No	No	1	6	5
57	R:R:D122	R:R:V118	45.8741	2.92	No	No	1	6	5
58	R:R:I114	R:R:W108	67.1265	3.52	Yes	Yes	1	6	8
59	R:R:F110	R:R:I114	15.8932	3.77	Yes	Yes	1	6	6
60	R:R:Q102	R:R:W108	16.7769	6.57	No	Yes	0	5	8
61	R:R:Q102	R:R:S192	13.4456	2.89	No	No	0	5	4
62	R:R:R190	R:R:S192	10.1017	6.59	No	No	0	1	4
63	R:R:L183	R:R:W108	13.1723	4.56	Yes	Yes	1	4	8
64	R:R:C115	R:R:W108	23.0006	3.92	Yes	Yes	1	9	8
65	R:R:C115	R:R:G182	13.3376	1.96	Yes	No	0	9	5
66	R:R:I174	R:R:I177	21.2142	4.42	Yes	Yes	9	7	3
67	R:R:F208	R:R:I177	11.4558	2.51	No	Yes	0	7	3
68	R:R:F208	R:R:T212	11.5766	5.19	No	No	0	7	4
69	R:R:Q126	R:R:T212	12.2886	2.83	Yes	No	0	7	4
70	R:R:F127	R:R:V173	11.8373	3.93	No	Yes	0	6	4
71	R:R:F265	R:R:I130	11.2142	7.54	Yes	No	0	9	8
72	R:R:F265	R:R:W269	15.4355	13.03	Yes	Yes	2	9	8
73	R:R:R140	R:R:V258	15.0032	3.92	Yes	No	0	9	8
74	R:R:R140	R:R:T255	42.0915	2.59	Yes	No	0	9	7
75	R:R:N308	R:R:P309	10.3751	1.63	No	Yes	0	9	9
76	R:R:V145	R:R:Y141	18.5315	7.57	No	Yes	3	7	8
77	R:R:V144	R:R:V145	32.8481	3.21	No	No	0	8	7
78	R:R:T255	R:R:V144	34.7743	1.59	No	No	0	7	8
79	R:R:L251	R:R:R140	27.2537	2.43	No	Yes	0	6	9
80	R:R:H146	R:R:V145	12.3522	6.92	Yes	No	3	5	7
81	R:R:W197	R:R:Y180	11.7673	6.75	Yes	No	6	5	4
82	R:R:F208	R:R:W197	16.1284	7.02	No	Yes	0	7	5
83	R:R:I177	R:R:I195	10.6357	2.94	Yes	No	0	3	5
84	R:R:G182	R:R:N196	10.1208	1.7	No	No	0	5	3
85	R:R:F217	R:R:Y273	25.8042	12.38	No	Yes	0	8	7
86	R:R:L241	R:R:L251	17.1074	4.15	Yes	No	0	1	6
87	R:R:D139	R:R:R140	61.4622	2.38	No	Yes	5	8	9
88	R:R:Q126	R:R:Y273	25.2765	5.64	Yes	Yes	2	7	7
89	R:R:F217	R:R:L270	21.0108	3.65	No	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7UL5

PDB Summary
PDB	7UL5
Class	A
SubFamily	Peptide
Type	Somatostatin
SubType	SST2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.1
Date	2022-06-29
D.O.I.	doi.org/10.1038/s41594-022-00859-8

Net Summary
I_min	1.55
Number of Linked Nodes	254
Number of Links	297
Number of Hubs	35
Number of Links mediated by Hubs	136
Number of Communities	13
Number of Nodes involved in Communities	60
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	48660
Length Of Smallest Path	3
Average Path Length	14.156
Length of Longest Path	32
Minimum Path Strength	1.325
Average Path Strength	3.79662
Maximum Path Strength	15.14
Minimum Path Correlation	0.7
Average Path Correlation	0.920142
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.2314
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8895
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7UL5_Chain_R L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N G R S S C T I N W P G G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S V R L L S G S R E K D R N L R R V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

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