psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	6.72	No	No	0	0	0
2	L:L:?1	L:L:T8	5	No	No	0	0	0
3	L:L:C2	L:L:C7	7.28	No	No	0	0	0
4	L:L:?4	L:L:F3	5.8	No	No	0	0	0
5	L:L:?4	L:L:K5	12.31	No	No	0	0	0
6	R:R:N43	R:R:T47	4.39	No	No	0	3	5
7	R:R:N43	R:R:V103	4.43	No	No	0	3	4
8	R:R:A104	R:R:N43	4.69	No	No	0	5	3
9	R:R:D295	R:R:L46	19	No	Yes	0	2	5
10	R:R:L96	R:R:Y50	2.34	Yes	Yes	0	7	7
11	R:R:A100	R:R:Y50	5.34	No	Yes	0	6	7
12	R:R:D295	R:R:Y50	6.9	No	Yes	0	2	7
13	R:R:V298	R:R:Y50	5.05	No	Yes	0	6	7
14	R:R:V299	R:R:Y50	3.79	No	Yes	0	5	7
15	R:R:F51	R:R:P97	4.33	No	No	0	5	8
16	R:R:C306	R:R:V53	3.42	No	No	0	8	7
17	R:R:C54	R:R:L58	6.35	No	No	0	6	6
18	R:R:G57	R:R:I56	1.76	No	No	0	8	4
19	R:R:G57	R:R:M93	3.49	No	No	0	8	6
20	R:R:C306	R:R:G57	1.96	No	No	0	8	8
21	R:R:E90	R:R:L58	9.28	No	No	0	7	6
22	R:R:L58	R:R:M93	2.83	No	No	0	6	6
23	R:R:C59	R:R:G60	1.96	No	No	0	5	8
24	R:R:I65	R:R:N61	2.83	No	No	0	7	9
25	R:R:A86	R:R:N61	3.13	No	No	0	9	9
26	R:R:E90	R:R:N61	14.46	No	No	0	7	9
27	R:R:F323	R:R:L63	10.96	No	No	0	6	6
28	R:R:F319	R:R:V64	2.62	Yes	No	0	8	9
29	R:R:I65	R:R:I68	4.42	No	No	3	7	7
30	R:R:I65	R:R:L69	7.14	No	No	3	7	3
31	R:R:R70	R:R:Y66	9.26	No	No	0	4	3
32	R:R:F319	R:R:V67	9.18	Yes	No	4	8	7
33	R:R:F323	R:R:V67	20.97	No	No	4	6	7
34	R:R:V326	R:R:V67	4.81	No	No	0	5	7
35	R:R:I68	R:R:L69	4.28	No	No	3	7	3
36	R:R:I68	R:R:M74	4.37	No	Yes	0	7	7
37	R:R:R70	R:R:V326	3.92	No	No	0	4	5
38	R:R:N325	R:R:Y71	6.98	No	No	0	4	6
39	R:R:V326	R:R:Y71	11.36	No	No	0	5	6
40	R:R:M74	R:R:N79	2.8	Yes	No	0	7	8
41	R:R:I80	R:R:M74	2.92	No	Yes	0	5	7
42	R:R:L83	R:R:M74	4.24	No	Yes	0	6	7
43	R:R:T76	R:R:T78	3.14	No	No	0	7	8
44	R:R:N79	R:R:T76	8.77	No	No	0	8	7
45	R:R:I77	R:R:R154	3.76	No	No	0	4	5
46	R:R:A159	R:R:I80	3.25	No	No	0	7	5
47	R:R:D139	R:R:Y81	6.9	No	No	0	8	7
48	R:R:I162	R:R:Y81	6.04	No	No	0	5	7
49	R:R:L83	R:R:N84	2.75	No	No	0	6	9
50	R:R:I87	R:R:L83	4.28	No	No	0	7	6
51	R:R:N84	R:R:T163	8.77	No	No	0	9	7
52	R:R:L85	R:R:N308	6.87	No	Yes	0	9	9
53	R:R:I87	R:R:L91	2.85	No	No	0	7	7
54	R:R:D89	R:R:S305	5.89	No	No	0	9	8
55	R:R:D89	R:R:P309	4.83	No	No	0	9	9
56	R:R:L91	R:R:N125	5.49	No	Yes	0	7	7
57	R:R:D122	R:R:F92	5.97	Yes	Yes	2	6	6
58	R:R:F92	R:R:N125	4.83	Yes	Yes	0	6	7
59	R:R:F92	R:R:Q126	12.88	Yes	Yes	2	6	7
60	R:R:F92	R:R:Y302	12.38	Yes	No	2	6	7
61	R:R:F92	R:R:S305	5.28	Yes	No	0	6	8
62	R:R:L96	R:R:M93	2.83	Yes	No	0	7	6
63	R:R:G95	R:R:L94	3.42	No	No	0	6	5
64	R:R:L96	R:R:Y302	11.72	Yes	No	0	7	7
65	R:R:F98	R:R:I114	6.28	No	No	1	5	6
66	R:R:F98	R:R:V118	5.24	No	Yes	1	5	5
67	R:R:L105	R:R:M101	7.07	No	No	1	5	5
68	R:R:M101	R:R:P109	8.39	No	Yes	1	5	4
69	R:R:F110	R:R:M101	9.95	No	No	1	6	5
70	R:R:Q102	R:R:W108	4.38	No	Yes	0	5	8
71	R:R:Q102	R:R:S192	8.66	No	No	0	5	4
72	R:R:A104	R:R:L105	3.15	No	No	0	5	5
73	R:R:L105	R:R:P109	3.28	No	Yes	1	5	4
74	R:R:P109	R:R:W108	4.05	Yes	Yes	1	4	8
75	R:R:F110	R:R:W108	16.04	No	Yes	1	6	8
76	R:R:G111	R:R:W108	2.81	No	Yes	0	7	8
77	R:R:I114	R:R:W108	2.35	No	Yes	1	6	8
78	R:R:C193	R:R:W108	7.84	No	Yes	0	9	8
79	R:R:F110	R:R:P109	11.56	No	Yes	1	6	4
80	R:R:K112	R:R:L183	5.64	No	No	0	3	4
81	R:R:I114	R:R:V118	4.61	No	Yes	1	6	5
82	R:R:C115	R:R:M119	3.24	No	No	0	9	5
83	R:R:C115	R:R:C193	7.28	No	No	0	9	9
84	R:R:A181	R:R:R116	2.77	No	No	0	4	6
85	R:R:I174	R:R:T120	3.04	No	No	0	7	6
86	R:R:M178	R:R:T120	3.01	No	No	0	5	6
87	R:R:N125	R:R:V121	4.43	Yes	No	0	7	5
88	R:R:D122	R:R:G123	3.35	Yes	No	0	6	4
89	R:R:D122	R:R:Q126	3.92	Yes	Yes	2	6	7
90	R:R:D122	R:R:Y302	5.75	Yes	No	2	6	7
91	R:R:G123	R:R:I174	3.53	No	No	0	4	7
92	R:R:I124	R:R:N125	2.83	No	Yes	0	5	7
93	R:R:I124	R:R:L171	2.85	No	No	0	5	3
94	R:R:F127	R:R:Q126	3.51	No	Yes	0	6	7
95	R:R:Q126	R:R:W269	8.76	Yes	Yes	2	7	8
96	R:R:F127	R:R:V173	2.62	No	No	0	6	4
97	R:R:T128	R:R:W167	8.49	Yes	No	0	7	9
98	R:R:S170	R:R:T128	6.4	No	Yes	0	7	7
99	R:R:I130	R:R:P220	3.39	No	No	0	8	9
100	R:R:I130	R:R:W269	5.87	No	Yes	0	8	8
101	R:R:L133	R:R:N308	2.75	No	Yes	5	9	9
102	R:R:L133	R:R:Y312	3.52	No	Yes	5	9	9
103	R:R:P220	R:R:T134	1.75	No	No	0	9	7
104	R:R:I223	R:R:T134	4.56	No	No	0	6	7
105	R:R:M136	R:R:Y312	5.99	No	Yes	0	9	9
106	R:R:I224	R:R:S137	3.1	No	No	0	7	9
107	R:R:C227	R:R:S137	1.72	No	No	0	7	9
108	R:R:S137	R:R:Y228	3.82	No	Yes	0	9	9
109	R:R:R140	R:R:Y228	4.12	No	Yes	0	9	9
110	R:R:M257	R:R:R140	3.72	No	No	0	8	9
111	R:R:R140	R:R:Y312	9.26	No	Yes	0	9	9
112	R:R:V145	R:R:Y141	8.83	No	Yes	0	7	8
113	R:R:C227	R:R:Y141	6.72	No	Yes	0	7	8
114	R:R:F230	R:R:Y141	4.13	No	Yes	0	4	8
115	R:R:I231	R:R:Y141	3.63	No	Yes	0	9	8
116	R:R:A143	R:R:R154	2.77	No	No	0	8	5
117	R:R:H146	R:R:V145	4.15	No	No	0	5	7
118	R:R:H146	R:R:S150	2.79	No	No	0	5	5
119	R:R:K149	R:R:K152	2.87	No	No	0	4	4
120	R:R:R154	R:R:S150	2.64	No	No	0	5	5
121	R:R:K152	R:R:W153	32.49	No	No	0	4	3
122	R:R:R155	R:R:R157	2.13	No	No	0	6	4
123	R:R:R157	R:R:T158	5.17	No	No	6	4	5
124	R:R:M161	R:R:R157	7.44	No	No	6	1	4
125	R:R:M161	R:R:T158	3.01	No	No	6	1	5
126	R:R:K160	R:R:T163	6.01	No	No	0	1	7
127	R:R:V173	R:R:Y211	6.31	No	No	0	4	4
128	R:R:I174	R:R:I177	8.83	No	No	0	7	3
129	R:R:L175	R:R:P176	3.28	No	No	0	4	8
130	R:R:I179	R:R:L175	5.71	No	No	0	4	4
131	R:R:I177	R:R:I195	4.42	No	No	0	3	5
132	R:R:F208	R:R:I177	3.77	No	No	0	7	3
133	R:R:I179	R:R:Y180	7.25	No	No	0	4	4
134	R:R:W197	R:R:Y180	5.79	No	No	0	5	4
135	R:R:L183	R:R:S185	4.5	No	No	0	4	2
136	R:R:C193	R:R:L183	4.76	No	No	0	9	4
137	R:R:N186	R:R:R184	7.23	No	No	0	1	2
138	R:R:S185	R:R:S191	4.89	No	No	0	2	5
139	R:R:N186	R:R:R190	12.05	No	No	0	1	1
140	R:R:R190	R:R:W188	5	No	No	0	1	2
141	R:R:N196	R:R:T194	2.92	No	No	0	3	4
142	R:R:N196	R:R:Y205	11.63	No	No	0	3	4
143	R:R:P198	R:R:W197	12.16	No	No	0	5	5
144	R:R:G207	R:R:T206	1.82	No	No	0	4	3
145	R:R:T206	R:R:V280	4.76	No	No	0	3	4
146	R:R:F208	R:R:T212	7.78	No	No	0	7	4
147	R:R:I209	R:R:N276	5.66	No	No	0	5	6
148	R:R:L215	R:R:Y211	4.69	No	No	0	4	4
149	R:R:T212	R:R:Y273	4.99	No	No	0	4	7
150	R:R:F213	R:R:L218	3.65	No	No	0	5	4
151	R:R:F213	R:R:Y273	11.35	No	No	0	5	7
152	R:R:I214	R:R:L215	2.85	No	No	0	4	4
153	R:R:I214	R:R:L218	4.28	No	No	0	4	4
154	R:R:G216	R:R:Y273	2.9	No	No	0	6	7
155	R:R:F217	R:R:F265	3.22	No	No	0	8	9
156	R:R:F217	R:R:W269	3.01	No	Yes	0	8	8
157	R:R:F217	R:R:L270	6.09	No	No	0	8	5
158	R:R:P220	R:R:V219	3.53	No	No	0	9	5
159	R:R:I223	R:R:V219	3.07	No	No	0	6	5
160	R:R:C225	R:R:L221	3.17	No	No	0	5	6
161	R:R:L226	R:R:T222	2.95	No	No	0	5	4
162	R:R:V258	R:R:Y228	7.57	No	Yes	0	8	9
163	R:R:V261	R:R:Y228	3.79	No	Yes	0	8	9
164	R:R:F230	R:R:L229	2.44	No	No	0	4	4
165	R:R:I233	R:R:L229	2.85	No	No	0	3	4
166	R:R:I232	R:R:V254	4.61	No	No	0	5	8
167	R:R:I232	R:R:T255	3.04	No	No	0	5	7
168	R:R:E251	R:R:K236	8.1	No	No	0	6	4
169	R:R:R256	R:R:S259	6.59	No	No	0	6	4
170	R:R:I260	R:R:R256	3.76	No	No	0	6	6
171	R:R:I260	R:R:L311	7.14	No	No	0	6	8
172	R:R:C268	R:R:W269	2.61	No	Yes	2	8	8
173	R:R:A303	R:R:C268	1.81	No	No	0	5	8
174	R:R:C268	R:R:N304	3.15	No	No	2	8	9
175	R:R:N304	R:R:W269	4.52	No	Yes	2	9	8
176	R:R:L270	R:R:P271	3.28	No	No	0	5	9
177	R:R:P271	R:R:V297	1.77	No	No	0	9	7
178	R:R:F272	R:R:N276	12.08	No	No	0	6	6
179	R:R:F272	R:R:V297	2.62	No	No	0	6	7
180	R:R:F272	R:R:T301	3.89	No	No	0	6	7
181	R:R:F275	R:R:I274	2.51	No	No	0	4	5
182	R:R:F275	R:R:V297	7.87	No	No	0	4	7
183	R:R:M282	R:R:S281	3.07	No	No	0	3	4
184	R:R:I284	R:R:L290	2.85	No	No	0	1	4
185	R:R:P286	R:R:S285	1.78	No	No	0	2	2
186	R:R:P288	R:R:T287	5.25	No	No	0	3	1
187	R:R:L290	R:R:T287	5.9	No	No	0	4	1
188	R:R:G292	R:R:K291	1.74	No	No	0	1	3
189	R:R:F294	R:R:V298	2.62	No	No	0	4	6
190	R:R:F296	R:R:L300	8.53	No	No	0	5	7
191	R:R:N308	R:R:P309	3.26	Yes	No	0	9	9
192	R:R:N308	R:R:Y312	2.33	Yes	Yes	5	9	9
193	R:R:F319	R:R:S316	2.64	Yes	No	0	8	8
194	R:R:F319	R:R:F323	7.5	Yes	No	4	8	6
195	R:R:N325	R:R:Q324	11.88	No	No	0	4	4
196	R:R:G95	R:R:L96	1.71	No	Yes	0	6	7
197	R:R:G168	R:R:L171	1.71	No	No	0	4	3
198	R:R:A313	R:R:V64	1.7	No	No	0	7	9
199	R:R:C132	R:R:T128	1.69	No	Yes	0	8	7
200	R:R:I148	R:R:P147	1.69	No	No	0	5	8
201	R:R:A88	R:R:T128	1.68	No	Yes	0	8	7
202	R:R:A289	R:R:T287	1.68	No	No	0	1	1
203	R:R:L96	R:R:P97	1.64	Yes	No	0	7	8
204	R:R:N196	R:R:P198	1.63	No	No	0	3	5
205	R:R:S278	R:R:S281	1.63	No	No	0	4	4
206	R:R:S170	R:R:V166	1.62	No	No	0	7	6
207	R:R:A289	R:R:M293	1.61	No	No	0	1	4
208	R:R:V117	R:R:V118	1.6	No	Yes	0	5	5
209	R:R:V169	R:R:V173	1.6	No	No	0	4	4
210	R:R:V258	R:R:V262	1.6	No	No	0	8	7
211	R:R:T41	R:R:V45	1.59	No	No	0	4	5
212	R:R:C132	R:R:L85	1.59	No	No	0	8	9
213	R:R:A303	R:R:L300	1.58	No	No	0	5	7
214	R:R:I138	R:R:V135	1.54	No	No	0	6	7
215	R:R:I162	R:R:V135	1.54	No	No	0	5	7
216	R:R:I231	R:R:V144	1.54	No	No	0	9	8
217	R:R:I209	R:R:V277	1.54	No	No	0	5	5
218	R:R:I209	R:R:V280	1.54	No	No	0	5	4
219	R:R:I266	R:R:V262	1.54	No	No	0	6	7
220	R:R:H146	R:R:P147	1.53	No	No	0	5	8
221	R:R:I82	R:R:T78	1.52	No	No	0	8	8
222	R:R:I162	R:R:T163	1.52	No	No	0	5	7
223	R:R:I223	R:R:T222	1.52	No	No	0	6	4
224	R:R:L85	R:R:S129	1.5	No	No	0	9	9
225	R:R:L142	R:R:S150	1.5	No	No	0	4	5
226	R:R:L46	R:R:V45	1.49	Yes	No	0	5	5
227	R:R:L46	R:R:V103	1.49	Yes	No	0	5	4
228	R:R:L99	R:R:V118	1.49	No	Yes	0	6	5
229	R:R:L221	R:R:V262	1.49	No	No	0	6	7
230	R:R:L311	R:R:V261	1.49	No	No	0	8	8
231	R:R:N318	R:R:S316	1.49	No	No	0	5	8
232	R:R:L40	R:R:T41	1.47	No	No	0	2	4
233	R:R:I232	R:R:I233	1.47	No	No	0	5	3
234	R:R:I179	R:R:M178	1.46	No	No	0	4	5
235	R:R:I148	R:R:K149	1.45	No	No	0	5	4
236	R:R:G202	R:R:Y205	1.45	No	No	0	2	4
237	R:R:P156	R:R:R155	1.44	No	No	0	3	6
238	R:R:K160	R:R:M164	1.44	No	No	0	1	4
239	R:R:I49	R:R:L46	1.43	No	Yes	0	5	5
240	R:R:H107	R:R:S191	1.39	No	No	0	4	5
241	R:R:F131	R:R:S170	1.32	No	No	0	6	7
242	R:R:F275	R:R:S278	1.32	No	No	0	4	4
243	R:R:R116	R:R:V117	1.31	No	No	0	6	5
244	R:R:F48	R:R:T47	1.3	No	No	0	6	5
245	R:R:R184	R:R:T194	1.29	No	No	0	2	4
246	R:R:S322	R:R:Y71	1.27	No	No	0	5	6
247	R:R:F314	R:R:I310	1.26	No	No	0	7	6
248	R:R:F314	R:R:L315	1.22	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L46	5.8525	4	0	5
2	R:R:Y50	4.684	5	0	7
3	R:R:M74	3.5825	4	0	7
4	R:R:F92	8.268	5	2	6
5	R:R:L96	4.048	5	0	7
6	R:R:W108	6.245	6	1	8
7	R:R:P109	6.82	4	1	4
8	R:R:V118	3.235	4	1	5
9	R:R:D122	4.7475	4	2	6
10	R:R:N125	4.395	4	0	7
11	R:R:Q126	7.2675	4	2	7
12	R:R:T128	4.565	4	0	7
13	R:R:Y141	5.8275	4	0	8
14	R:R:Y228	4.825	4	0	9
15	R:R:W269	4.954	5	2	8
16	R:R:N308	3.8025	4	5	9
17	R:R:Y312	5.275	4	5	9
18	R:R:F319	5.485	4	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D295	R:R:L46	71.501	19	No	Yes	0	2	5
2	R:R:L46	R:R:V103	62.3709	1.49	Yes	No	0	5	4
3	R:R:N43	R:R:V103	60.4876	4.43	No	No	0	3	4
4	R:R:L96	R:R:Y50	81.826	2.34	Yes	Yes	0	7	7
5	R:R:D295	R:R:Y50	73.2696	6.9	No	Yes	0	2	7
6	R:R:L96	R:R:M93	27.2945	2.83	Yes	No	0	7	6
7	R:R:L58	R:R:M93	17.6386	2.83	No	No	0	6	6
8	R:R:E90	R:R:L58	13.8719	9.28	No	No	0	7	6
9	R:R:E90	R:R:N61	11.9694	14.46	No	No	0	7	9
10	R:R:L83	R:R:M74	17.3327	4.24	No	Yes	0	6	7
11	R:R:I87	R:R:L83	32.7247	4.28	No	No	0	7	6
12	R:R:I87	R:R:L91	34.2256	2.85	No	No	0	7	7
13	R:R:L91	R:R:N125	35.7361	5.49	No	Yes	0	7	7
14	R:R:F92	R:R:N125	43.1453	4.83	Yes	Yes	0	6	7
15	R:R:F92	R:R:Y302	63.9293	12.38	Yes	No	2	6	7
16	R:R:L96	R:R:Y302	100	11.72	Yes	No	0	7	7
17	R:R:H146	R:R:V145	20.6023	4.15	No	No	0	5	7
18	R:R:V145	R:R:Y141	22.3614	8.83	No	Yes	0	7	8
19	R:R:C227	R:R:Y141	37.3327	6.72	No	Yes	0	7	8
20	R:R:C227	R:R:S137	38.9006	1.72	No	No	0	7	9
21	R:R:S137	R:R:Y228	41.979	3.82	No	Yes	0	9	9
22	R:R:R140	R:R:Y228	57.4379	4.12	No	Yes	0	9	9
23	R:R:R140	R:R:Y312	59.8948	9.26	No	Yes	0	9	9
24	R:R:N308	R:R:Y312	62.0363	2.33	Yes	Yes	5	9	9
25	R:R:N308	R:R:P309	74.8757	3.26	Yes	No	0	9	9
26	R:R:D89	R:R:P309	75.8509	4.83	No	No	0	9	9
27	R:R:D89	R:R:S305	76.8929	5.89	No	No	0	9	8
28	R:R:F92	R:R:S305	77.9254	5.28	Yes	No	0	6	8
29	R:R:N84	R:R:T163	15.5163	8.77	No	No	0	9	7
30	R:R:L83	R:R:N84	17.3709	2.75	No	No	0	6	9
31	R:R:L85	R:R:N308	16.8356	6.87	No	Yes	0	9	9
32	R:R:D122	R:R:Y302	37.2849	5.75	Yes	No	2	6	7
33	R:R:F92	R:R:Q126	56.0994	12.88	Yes	Yes	2	6	7
34	R:R:D122	R:R:Q126	32.2849	3.92	Yes	Yes	2	6	7
35	R:R:I114	R:R:W108	16.5201	2.35	No	Yes	1	6	8
36	R:R:P109	R:R:W108	42.3136	4.05	Yes	Yes	1	4	8
37	R:R:L105	R:R:P109	46.3671	3.28	No	Yes	1	5	4
38	R:R:A104	R:R:L105	52.7629	3.15	No	No	0	5	5
39	R:R:A104	R:R:N43	54.7228	4.69	No	No	0	5	3
40	R:R:I114	R:R:V118	11.8451	4.61	No	Yes	1	6	5
41	R:R:C193	R:R:W108	18.805	7.84	No	Yes	0	9	8
42	R:R:C193	R:R:L183	11.8929	4.76	No	No	0	9	4
43	R:R:G123	R:R:I174	40.7457	3.53	No	No	0	4	7
44	R:R:D122	R:R:G123	42.2275	3.35	Yes	No	0	6	4
45	R:R:I174	R:R:T120	29.0535	3.04	No	No	0	7	6
46	R:R:M178	R:R:T120	27.3805	3.01	No	No	0	5	6
47	R:R:F127	R:R:Q126	17.5335	3.51	No	Yes	0	6	7
48	R:R:Q126	R:R:W269	74.3403	8.76	Yes	Yes	2	7	8
49	R:R:F127	R:R:V173	15.2008	2.62	No	No	0	6	4
50	R:R:C132	R:R:L85	13.2983	1.59	No	No	0	8	9
51	R:R:C132	R:R:T128	11.5201	1.69	No	Yes	0	8	7
52	R:R:I130	R:R:W269	24.1683	5.87	No	Yes	0	8	8
53	R:R:I130	R:R:P220	21.8451	3.39	No	No	0	8	9
54	R:R:F230	R:R:Y141	11.5201	4.13	No	Yes	0	4	8
55	R:R:V173	R:R:Y211	10.5163	6.31	No	No	0	4	4
56	R:R:I174	R:R:I177	12.9541	8.83	No	No	0	7	3
57	R:R:I179	R:R:M178	25.6883	1.46	No	No	0	4	5
58	R:R:I179	R:R:Y180	20.4971	7.25	No	No	0	4	4
59	R:R:W197	R:R:Y180	18.7285	5.79	No	No	0	5	4
60	R:R:N196	R:R:P198	15.1338	1.63	No	No	0	3	5
61	R:R:P198	R:R:W197	16.9407	12.16	No	No	0	5	5
62	R:R:I209	R:R:N276	12.3231	5.66	No	No	0	5	6
63	R:R:F272	R:R:N276	14.7323	12.08	No	No	0	6	6
64	R:R:F272	R:R:V297	19.4933	2.62	No	No	0	6	7
65	R:R:P271	R:R:V297	33.3174	1.77	No	No	0	9	7
66	R:R:L270	R:R:P271	35.5545	3.28	No	No	0	5	9
67	R:R:F217	R:R:L270	37.7725	6.09	No	No	0	8	5
68	R:R:F217	R:R:W269	42.1511	3.01	No	Yes	0	8	8
69	R:R:F275	R:R:V297	12.3231	7.87	No	No	0	4	7
70	R:R:D122	R:R:F92	19.8757	5.97	Yes	Yes	2	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7Y27_nogp

PDB Summary
PDB	7Y27_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.72
Number of Linked Nodes	245
Number of Links	248
Number of Hubs	18
Number of Links mediated by Hubs	70
Number of Communities	6
Number of Nodes involved in Communities	27
Number of Links involved in Communities	32

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	23706
Length Of Smallest Path	3
Average Path Length	14.7138
Length of Longest Path	34
Minimum Path Strength	1.24
Average Path Strength	5.32563
Maximum Path Strength	17.68
Minimum Path Correlation	0.7
Average Path Correlation	0.971942
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	69.9394
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.455
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • binding • neuropeptide binding • peptide binding • protein binding • PDZ domain binding • protein domain specific binding • multicellular organismal process • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cerebellum development • metencephalon development • hindbrain development • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to prostaglandin E • cellular response to ketone • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • response to acid chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • regulation of biological quality • somatostatin signaling pathway • hormone-mediated signaling pathway • somatostatin receptor signaling pathway • cell-cell signaling • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • response to osmotic stress • hyperosmotic response • response to abiotic stimulus • cell surface receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient • response to pH • response to acidic pH • digestion • dense core granule • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • GABA-ergic synapse • somatodendritic compartment • cell body • neuronal cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	6919011
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid DTR D-Tryptophan (R)-tryptophan
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7Y27_nogp_Chain_R L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V P A I S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y27_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.