psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C14	L:L:C3	7.28	Yes	No	3	0	0
2	L:L:C3	R:R:R184	4.18	No	Yes	3	0	2
3	L:L:K4	R:R:P286	3.35	No	No	0	0	2
4	L:L:N5	R:R:Y205	4.65	No	Yes	0	0	4
5	L:L:N5	R:R:S279	2.98	No	No	0	0	4
6	L:L:F11	L:L:F6	4.29	No	No	0	0	0
7	L:L:F6	R:R:F294	6.43	No	No	0	0	4
8	L:L:F7	R:R:Y205	12.38	No	Yes	0	0	4
9	L:L:F7	R:R:F208	3.22	No	Yes	0	0	7
10	L:L:K9	L:L:W8	15.08	Yes	No	1	0	0
11	L:L:W8	R:R:F208	8.02	No	Yes	1	0	7
12	L:L:W8	R:R:T212	3.64	No	No	1	0	4
13	L:L:K9	R:R:D122	11.06	Yes	Yes	1	0	6
14	L:L:K9	R:R:Q126	8.14	Yes	Yes	1	0	7
15	L:L:K9	R:R:Y302	4.78	Yes	Yes	1	0	7
16	L:L:F11	R:R:K291	13.65	No	No	0	0	3
17	L:L:T12	R:R:R184	5.17	Yes	Yes	0	0	2
18	L:L:T12	R:R:S192	3.2	Yes	No	0	0	4
19	L:L:T12	R:R:T194	3.14	Yes	No	0	0	4
20	L:L:C14	L:L:S13	3.44	Yes	No	3	0	0
21	L:L:S13	R:R:R190	9.22	No	Yes	3	0	1
22	L:L:C14	R:R:R184	5.57	Yes	Yes	3	0	2
23	L:L:C14	R:R:N186	6.3	Yes	No	3	0	1
24	L:L:C14	R:R:R190	6.96	Yes	Yes	3	0	1
25	R:R:N43	R:R:T47	4.39	No	No	0	3	5
26	R:R:N43	R:R:V103	4.43	No	No	0	3	4
27	R:R:A104	R:R:N43	4.69	No	No	0	5	3
28	R:R:D295	R:R:L46	19	No	No	0	2	5
29	R:R:A100	R:R:Y50	5.34	No	Yes	0	6	7
30	R:R:D295	R:R:Y50	6.9	No	Yes	0	2	7
31	R:R:V298	R:R:Y50	5.05	No	Yes	0	6	7
32	R:R:V299	R:R:Y50	3.79	No	Yes	0	5	7
33	R:R:F51	R:R:P97	4.33	No	No	0	5	8
34	R:R:C306	R:R:V53	3.42	No	No	0	8	7
35	R:R:C54	R:R:L58	6.35	No	No	0	6	6
36	R:R:G57	R:R:M93	3.49	No	No	0	8	6
37	R:R:E90	R:R:L58	9.28	No	No	0	7	6
38	R:R:L58	R:R:M93	2.83	No	No	0	6	6
39	R:R:I65	R:R:N61	2.83	No	No	0	7	9
40	R:R:A86	R:R:N61	3.13	No	No	0	9	9
41	R:R:E90	R:R:N61	14.46	No	No	0	7	9
42	R:R:F323	R:R:L63	10.96	No	No	0	6	6
43	R:R:I65	R:R:I68	4.42	No	No	4	7	7
44	R:R:I65	R:R:L69	7.14	No	No	4	7	3
45	R:R:R70	R:R:Y66	9.26	No	No	0	4	3
46	R:R:F319	R:R:V67	9.18	Yes	No	5	8	7
47	R:R:F323	R:R:V67	20.97	No	No	5	6	7
48	R:R:V326	R:R:V67	4.81	No	No	0	5	7
49	R:R:I68	R:R:L69	4.28	No	No	4	7	3
50	R:R:I68	R:R:M74	4.37	No	Yes	0	7	7
51	R:R:R70	R:R:V326	3.92	No	No	0	4	5
52	R:R:N325	R:R:Y71	6.98	No	No	0	4	6
53	R:R:V326	R:R:Y71	11.36	No	No	0	5	6
54	R:R:M74	R:R:N79	2.8	Yes	No	0	7	8
55	R:R:I80	R:R:M74	2.92	No	Yes	0	5	7
56	R:R:L83	R:R:M74	4.24	No	Yes	0	6	7
57	R:R:T76	R:R:T78	3.14	No	No	0	7	8
58	R:R:N79	R:R:T76	8.77	No	No	0	8	7
59	R:R:I77	R:R:R154	3.76	No	No	0	4	5
60	R:R:A159	R:R:I80	3.25	No	No	0	7	5
61	R:R:D139	R:R:Y81	6.9	No	No	0	8	7
62	R:R:I162	R:R:Y81	6.04	No	No	0	5	7
63	R:R:L83	R:R:N84	2.75	No	No	0	6	9
64	R:R:I87	R:R:L83	4.28	No	No	0	7	6
65	R:R:N84	R:R:T163	8.77	No	No	0	9	7
66	R:R:L85	R:R:N308	6.87	No	No	0	9	9
67	R:R:I87	R:R:L91	2.85	No	No	0	7	7
68	R:R:D89	R:R:S305	5.89	No	No	0	9	8
69	R:R:D89	R:R:P309	4.83	No	No	0	9	9
70	R:R:L91	R:R:N125	5.49	No	Yes	0	7	7
71	R:R:D122	R:R:F92	5.97	Yes	Yes	1	6	6
72	R:R:F92	R:R:N125	4.83	Yes	Yes	0	6	7
73	R:R:F92	R:R:Q126	12.88	Yes	Yes	1	6	7
74	R:R:F92	R:R:Y302	12.38	Yes	Yes	1	6	7
75	R:R:F92	R:R:S305	5.28	Yes	No	0	6	8
76	R:R:L96	R:R:M93	2.83	Yes	No	0	7	6
77	R:R:G95	R:R:L94	3.42	No	No	0	6	5
78	R:R:L96	R:R:Y302	11.72	Yes	Yes	0	7	7
79	R:R:F98	R:R:I114	6.28	No	No	2	5	6
80	R:R:F98	R:R:V118	5.24	No	Yes	2	5	5
81	R:R:L105	R:R:M101	7.07	No	No	2	5	5
82	R:R:M101	R:R:P109	8.39	No	Yes	2	5	4
83	R:R:F110	R:R:M101	9.95	No	No	2	6	5
84	R:R:Q102	R:R:W108	4.38	No	Yes	0	5	8
85	R:R:Q102	R:R:S192	8.66	No	No	0	5	4
86	R:R:A104	R:R:L105	3.15	No	No	0	5	5
87	R:R:L105	R:R:P109	3.28	No	Yes	2	5	4
88	R:R:P109	R:R:W108	4.05	Yes	Yes	2	4	8
89	R:R:F110	R:R:W108	16.04	No	Yes	2	6	8
90	R:R:G111	R:R:W108	2.81	No	Yes	0	7	8
91	R:R:C193	R:R:W108	7.84	No	Yes	0	9	8
92	R:R:F110	R:R:P109	11.56	No	Yes	2	6	4
93	R:R:K112	R:R:L183	5.64	No	No	0	3	4
94	R:R:I114	R:R:V118	4.61	No	Yes	2	6	5
95	R:R:C115	R:R:M119	3.24	No	No	0	9	5
96	R:R:C115	R:R:C193	7.28	No	No	0	9	9
97	R:R:A181	R:R:R116	2.77	No	No	0	4	6
98	R:R:I174	R:R:T120	3.04	No	No	0	7	6
99	R:R:M178	R:R:T120	3.01	No	No	0	5	6
100	R:R:N125	R:R:V121	4.43	Yes	No	0	7	5
101	R:R:D122	R:R:G123	3.35	Yes	No	0	6	4
102	R:R:D122	R:R:Q126	3.92	Yes	Yes	1	6	7
103	R:R:D122	R:R:Y302	5.75	Yes	Yes	1	6	7
104	R:R:G123	R:R:I174	3.53	No	No	0	4	7
105	R:R:I124	R:R:N125	2.83	No	Yes	0	5	7
106	R:R:I124	R:R:L171	2.85	No	No	0	5	3
107	R:R:F127	R:R:Q126	3.51	No	Yes	0	6	7
108	R:R:Q126	R:R:W269	8.76	Yes	Yes	0	7	8
109	R:R:T128	R:R:W167	8.49	Yes	No	0	7	9
110	R:R:S170	R:R:T128	6.4	No	Yes	0	7	7
111	R:R:I130	R:R:P220	3.39	No	No	0	8	9
112	R:R:I130	R:R:W269	5.87	No	Yes	0	8	8
113	R:R:L133	R:R:N308	2.75	No	No	0	9	9
114	R:R:L133	R:R:Y312	3.52	No	No	0	9	9
115	R:R:I223	R:R:T134	4.56	No	No	0	6	7
116	R:R:M136	R:R:Y312	5.99	No	No	0	9	9
117	R:R:I224	R:R:S137	3.1	No	No	0	7	9
118	R:R:S137	R:R:Y228	3.82	No	Yes	0	9	9
119	R:R:R140	R:R:Y228	4.12	No	Yes	0	9	9
120	R:R:M257	R:R:R140	3.72	No	No	0	8	9
121	R:R:R140	R:R:Y312	9.26	No	No	0	9	9
122	R:R:V145	R:R:Y141	8.83	No	Yes	0	7	8
123	R:R:C227	R:R:Y141	6.72	No	Yes	0	7	8
124	R:R:F230	R:R:Y141	4.13	No	Yes	0	4	8
125	R:R:I231	R:R:Y141	3.63	No	Yes	0	9	8
126	R:R:A143	R:R:R154	2.77	No	No	0	8	5
127	R:R:H146	R:R:V145	4.15	No	No	0	5	7
128	R:R:H146	R:R:S150	2.79	No	No	0	5	5
129	R:R:K149	R:R:K152	2.87	No	No	0	4	4
130	R:R:K152	R:R:W153	32.49	No	No	0	4	3
131	R:R:R157	R:R:T158	5.17	No	No	6	4	5
132	R:R:M161	R:R:R157	7.44	No	No	6	1	4
133	R:R:M161	R:R:T158	3.01	No	No	6	1	5
134	R:R:K160	R:R:T163	6.01	No	No	0	1	7
135	R:R:V173	R:R:Y211	6.31	No	No	0	4	4
136	R:R:I174	R:R:I177	8.83	No	No	0	7	3
137	R:R:L175	R:R:P176	3.28	No	No	0	4	8
138	R:R:I179	R:R:L175	5.71	No	No	0	4	4
139	R:R:I177	R:R:I195	4.42	No	No	0	3	5
140	R:R:F208	R:R:I177	3.77	Yes	No	0	7	3
141	R:R:I179	R:R:Y180	7.25	No	No	0	4	4
142	R:R:W197	R:R:Y180	5.79	No	No	0	5	4
143	R:R:L183	R:R:S185	4.5	No	No	0	4	2
144	R:R:C193	R:R:L183	4.76	No	No	0	9	4
145	R:R:N186	R:R:R184	7.23	No	Yes	3	1	2
146	R:R:S185	R:R:S191	4.89	No	No	0	2	5
147	R:R:N186	R:R:R190	12.05	No	Yes	3	1	1
148	R:R:R190	R:R:W188	5	Yes	No	0	1	2
149	R:R:N196	R:R:T194	2.92	No	No	0	3	4
150	R:R:N196	R:R:Y205	11.63	No	Yes	0	3	4
151	R:R:P198	R:R:W197	12.16	No	No	0	5	5
152	R:R:T206	R:R:V280	4.76	No	No	0	3	4
153	R:R:F208	R:R:T212	7.78	Yes	No	1	7	4
154	R:R:I209	R:R:N276	5.66	No	No	0	5	6
155	R:R:L215	R:R:Y211	4.69	No	No	0	4	4
156	R:R:T212	R:R:Y273	4.99	No	No	0	4	7
157	R:R:F213	R:R:L218	3.65	No	No	0	5	4
158	R:R:F213	R:R:Y273	11.35	No	No	0	5	7
159	R:R:I214	R:R:L215	2.85	No	No	0	4	4
160	R:R:I214	R:R:L218	4.28	No	No	0	4	4
161	R:R:G216	R:R:Y273	2.9	No	No	0	6	7
162	R:R:F217	R:R:F265	3.22	No	No	0	8	9
163	R:R:F217	R:R:W269	3.01	No	Yes	0	8	8
164	R:R:F217	R:R:L270	6.09	No	No	0	8	5
165	R:R:P220	R:R:V219	3.53	No	No	0	9	5
166	R:R:I223	R:R:V219	3.07	No	No	0	6	5
167	R:R:C225	R:R:L221	3.17	No	No	0	5	6
168	R:R:L226	R:R:T222	2.95	No	No	0	5	4
169	R:R:V258	R:R:Y228	7.57	No	Yes	0	8	9
170	R:R:V261	R:R:Y228	3.79	No	Yes	0	8	9
171	R:R:I233	R:R:L229	2.85	No	No	0	3	4
172	R:R:I232	R:R:V254	4.61	No	No	0	5	8
173	R:R:I232	R:R:T255	3.04	No	No	0	5	7
174	R:R:E251	R:R:K236	8.1	No	No	0	6	4
175	R:R:R256	R:R:S259	6.59	No	No	0	6	4
176	R:R:I260	R:R:R256	3.76	No	No	0	6	6
177	R:R:I260	R:R:L311	7.14	No	No	0	6	8
178	R:R:C268	R:R:N304	3.15	No	No	0	8	9
179	R:R:N304	R:R:W269	4.52	No	Yes	0	9	8
180	R:R:L270	R:R:P271	3.28	No	No	0	5	9
181	R:R:F272	R:R:N276	12.08	No	No	0	6	6
182	R:R:F272	R:R:T301	3.89	No	No	0	6	7
183	R:R:F275	R:R:V297	7.87	No	No	0	4	7
184	R:R:M282	R:R:S281	3.07	No	No	0	3	4
185	R:R:I284	R:R:L290	2.85	No	No	0	1	4
186	R:R:P288	R:R:T287	5.25	No	No	0	3	1
187	R:R:L290	R:R:T287	5.9	No	No	0	4	1
188	R:R:F296	R:R:L300	8.53	No	No	0	5	7
189	R:R:N308	R:R:P309	3.26	No	No	0	9	9
190	R:R:F319	R:R:F323	7.5	Yes	No	5	8	6
191	R:R:N325	R:R:Q324	11.88	No	No	0	4	4
192	L:L:F11	L:L:S13	2.64	No	No	0	0	0
193	R:R:R154	R:R:S150	2.64	No	No	0	5	5
194	R:R:F319	R:R:S316	2.64	Yes	No	0	8	8
195	R:R:F319	R:R:V64	2.62	Yes	No	0	8	9
196	R:R:F272	R:R:V297	2.62	No	No	0	6	7
197	R:R:F294	R:R:V298	2.62	No	No	0	4	6
198	R:R:F275	R:R:I274	2.51	No	No	0	4	5
199	R:R:F230	R:R:L229	2.44	No	No	0	4	4
200	R:R:I114	R:R:W108	2.35	No	Yes	2	6	8
201	R:R:R155	R:R:R157	2.13	No	No	0	6	4
202	R:R:C306	R:R:G57	1.96	No	No	0	8	8
203	R:R:C59	R:R:G60	1.96	No	No	0	5	8
204	R:R:G207	R:R:T206	1.82	No	No	0	4	3
205	R:R:A303	R:R:C268	1.81	No	No	0	5	8
206	R:R:P286	R:R:S285	1.78	No	No	0	2	2
207	R:R:P271	R:R:V297	1.77	No	No	0	9	7
208	R:R:G57	R:R:I56	1.76	No	No	0	8	4
209	R:R:G292	R:R:K291	1.74	No	No	0	1	3
210	R:R:C227	R:R:S137	1.72	No	No	0	7	9
211	R:R:G95	R:R:L96	1.71	No	Yes	0	6	7
212	R:R:G168	R:R:L171	1.71	No	No	0	4	3
213	R:R:A313	R:R:V64	1.7	No	No	0	7	9
214	R:R:C132	R:R:T128	1.69	No	Yes	0	8	7
215	R:R:I148	R:R:P147	1.69	No	No	0	5	8
216	R:R:A88	R:R:T128	1.68	No	Yes	0	8	7
217	R:R:A289	R:R:T287	1.68	No	No	0	1	1
218	R:R:L96	R:R:P97	1.64	Yes	No	0	7	8
219	R:R:N196	R:R:P198	1.63	No	No	0	3	5
220	R:R:S278	R:R:S281	1.63	No	No	0	4	4
221	R:R:S170	R:R:V166	1.62	No	No	0	7	6
222	R:R:A289	R:R:M293	1.61	No	No	0	1	4
223	R:R:V117	R:R:V118	1.6	No	Yes	0	5	5
224	R:R:V169	R:R:V173	1.6	No	No	0	4	4
225	R:R:V258	R:R:V262	1.6	No	No	0	8	7
226	R:R:T41	R:R:V45	1.59	No	No	0	4	5
227	R:R:C132	R:R:L85	1.59	No	No	0	8	9
228	R:R:A303	R:R:L300	1.58	No	No	0	5	7
229	L:L:T10	L:L:T12	1.57	No	Yes	0	0	0
230	R:R:I138	R:R:V135	1.54	No	No	0	6	7
231	R:R:I162	R:R:V135	1.54	No	No	0	5	7
232	R:R:I231	R:R:V144	1.54	No	No	0	9	8
233	R:R:I209	R:R:V277	1.54	No	No	0	5	5
234	R:R:I209	R:R:V280	1.54	No	No	0	5	4
235	R:R:I266	R:R:V262	1.54	No	No	0	6	7
236	R:R:H146	R:R:P147	1.53	No	No	0	5	8
237	R:R:I82	R:R:T78	1.52	No	No	0	8	8
238	R:R:I162	R:R:T163	1.52	No	No	0	5	7
239	R:R:I223	R:R:T222	1.52	No	No	0	6	4
240	R:R:L85	R:R:S129	1.5	No	No	0	9	9
241	R:R:L142	R:R:S150	1.5	No	No	0	4	5
242	R:R:L46	R:R:V45	1.49	No	No	0	5	5
243	R:R:L99	R:R:V118	1.49	No	Yes	0	6	5
244	R:R:L221	R:R:V262	1.49	No	No	0	6	7
245	R:R:L311	R:R:V261	1.49	No	No	0	8	8
246	R:R:N318	R:R:S316	1.49	No	No	0	5	8
247	R:R:L40	R:R:T41	1.47	No	No	0	2	4
248	R:R:I232	R:R:I233	1.47	No	No	0	5	3
249	R:R:I148	R:R:K149	1.45	No	No	0	5	4
250	R:R:G202	R:R:Y205	1.45	No	Yes	0	2	4
251	R:R:P156	R:R:R155	1.44	No	No	0	3	6
252	R:R:K160	R:R:M164	1.44	No	No	0	1	4
253	R:R:I49	R:R:L46	1.43	No	No	0	5	5
254	R:R:H107	R:R:S191	1.39	No	No	0	4	5
255	R:R:F131	R:R:S170	1.32	No	No	0	6	7
256	R:R:F275	R:R:S278	1.32	No	No	0	4	4
257	R:R:R116	R:R:V117	1.31	No	No	0	6	5
258	R:R:F48	R:R:T47	1.3	No	No	0	6	5
259	R:R:S322	R:R:Y71	1.27	No	No	0	5	6
260	R:R:F314	R:R:I310	1.26	No	No	0	7	6
261	R:R:F314	R:R:L315	1.22	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:K9	9.765	4	1	0
2	L:L:T12	3.27	4	0	0
3	L:L:C14	5.91	5	3	0
4	R:R:Y50	5.27	4	0	7
5	R:R:M74	3.5825	4	0	7
6	R:R:F92	8.268	5	1	6
7	R:R:L96	4.475	4	0	7
8	R:R:W108	6.245	6	2	8
9	R:R:P109	6.82	4	2	4
10	R:R:V118	3.235	4	2	5
11	R:R:D122	6.01	5	1	6
12	R:R:N125	4.395	4	0	7
13	R:R:Q126	7.442	5	1	7
14	R:R:T128	4.565	4	0	7
15	R:R:Y141	5.8275	4	0	8
16	R:R:R184	5.5375	4	3	2
17	R:R:R190	8.3075	4	3	1
18	R:R:Y205	7.5275	4	0	4
19	R:R:F208	5.6975	4	1	7
20	R:R:Y228	4.825	4	0	9
21	R:R:W269	5.54	4	0	8
22	R:R:Y302	8.6575	4	1	7
23	R:R:F319	5.485	4	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C14	R:R:R184	28.4043	5.57	Yes	Yes	3	0	2
2	L:L:T12	R:R:R184	35.9733	5.17	Yes	Yes	0	0	2
3	L:L:T12	R:R:T194	75.8026	3.14	Yes	No	0	0	4
4	R:R:N196	R:R:T194	76.9637	2.92	No	No	0	3	4
5	R:R:N196	R:R:Y205	84.5934	11.63	No	Yes	0	3	4
6	L:L:C14	L:L:S13	24.1974	3.44	Yes	No	3	0	0
7	L:L:F11	L:L:S13	22.8933	2.64	No	No	0	0	0
8	L:L:F11	L:L:F6	18.5391	4.29	No	No	0	0	0
9	L:L:F6	R:R:F294	17.001	6.43	No	No	0	0	4
10	L:L:F7	R:R:Y205	88.913	12.38	No	Yes	0	0	4
11	L:L:F7	R:R:F208	89.9528	3.22	No	Yes	0	0	7
12	L:L:W8	R:R:F208	86.712	8.02	No	Yes	1	0	7
13	L:L:K9	L:L:W8	100	15.08	Yes	No	1	0	0
14	L:L:K9	R:R:D122	27.6115	11.06	Yes	Yes	1	0	6
15	L:L:K9	R:R:Q126	41.5407	8.14	Yes	Yes	1	0	7
16	L:L:K9	R:R:Y302	36.4412	4.78	Yes	Yes	1	0	7
17	L:L:T12	R:R:S192	43.7199	3.2	Yes	No	0	0	4
18	R:R:Q102	R:R:S192	42.3335	8.66	No	No	0	5	4
19	R:R:Q102	R:R:W108	40.9384	4.38	No	Yes	0	5	8
20	R:R:P109	R:R:W108	12.7161	4.05	Yes	Yes	2	4	8
21	R:R:F294	R:R:V298	15.6449	2.62	No	No	0	4	6
22	R:R:V298	R:R:Y50	14.1068	5.05	No	Yes	0	6	7
23	R:R:L96	R:R:Y302	18.6777	11.72	Yes	Yes	0	7	7
24	R:R:L96	R:R:M93	13.3053	2.83	Yes	No	0	7	6
25	R:R:D122	R:R:F92	29.6391	5.97	Yes	Yes	1	6	6
26	R:R:F92	R:R:N125	37.741	4.83	Yes	Yes	0	6	7
27	R:R:L91	R:R:N125	30.6139	5.49	No	Yes	0	7	7
28	R:R:I87	R:R:L91	29.1755	2.85	No	No	0	7	7
29	R:R:I87	R:R:L83	27.7414	4.28	No	No	0	7	6
30	R:R:L83	R:R:M74	13.5869	4.24	No	Yes	0	6	7
31	R:R:F92	R:R:Q126	41.2807	12.88	Yes	Yes	1	6	7
32	R:R:F92	R:R:Y302	34.7472	12.38	Yes	Yes	1	6	7
33	R:R:F92	R:R:S305	74.3079	5.28	Yes	No	0	6	8
34	R:R:D89	R:R:S305	73.1121	5.89	No	No	0	9	8
35	R:R:D89	R:R:P309	71.9076	4.83	No	No	0	9	9
36	R:R:N308	R:R:P309	70.6945	3.26	No	No	0	9	9
37	R:R:L133	R:R:N308	58.0824	2.75	No	No	0	9	9
38	R:R:L133	R:R:Y312	56.748	3.52	No	No	0	9	9
39	R:R:R140	R:R:Y312	54.0618	9.26	No	No	0	9	9
40	R:R:R140	R:R:Y228	51.6182	4.12	No	Yes	0	9	9
41	R:R:S137	R:R:Y228	36.6622	3.82	No	Yes	0	9	9
42	R:R:C227	R:R:S137	33.7767	1.72	No	No	0	7	9
43	R:R:C227	R:R:Y141	32.3123	6.72	No	Yes	0	7	8
44	R:R:V145	R:R:Y141	19.0243	8.83	No	Yes	0	7	8
45	R:R:H146	R:R:V145	17.4732	4.15	No	No	0	5	7
46	R:R:L83	R:R:N84	14.2628	2.75	No	No	0	6	9
47	R:R:N84	R:R:T163	12.6598	8.77	No	No	0	9	7
48	R:R:L85	R:R:N308	14.5011	6.87	No	No	0	9	9
49	R:R:I114	R:R:W108	11.217	2.35	No	Yes	2	6	8
50	R:R:C193	R:R:W108	12.7854	7.84	No	Yes	0	9	8
51	R:R:Q126	R:R:W269	30.081	8.76	Yes	Yes	0	7	8
52	R:R:C132	R:R:L85	11.3383	1.59	No	No	0	8	9
53	R:R:T212	R:R:Y273	14.2238	4.99	No	No	0	4	7
54	R:R:F213	R:R:Y273	11.087	11.35	No	No	0	5	7
55	R:R:F217	R:R:W269	18.4784	3.01	No	Yes	0	8	8
56	R:R:F217	R:R:L270	16.5634	6.09	No	No	0	8	5
57	R:R:L270	R:R:P271	15.5929	3.28	No	No	0	5	9
58	R:R:P271	R:R:V297	14.6138	1.77	No	No	0	9	7
59	L:L:W8	R:R:T212	12.3825	3.64	No	No	1	0	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C3	R:R:R184	4.18	3	No	Yes	0	2	0	1
L:L:K4	R:R:P286	3.35	0	No	No	0	2	0	1
L:L:N5	R:R:Y205	4.65	0	No	Yes	0	4	0	1
L:L:N5	R:R:S279	2.98	0	No	No	0	4	0	1
L:L:F6	R:R:F294	6.43	0	No	No	0	4	0	1
L:L:F7	R:R:Y205	12.38	0	No	Yes	0	4	0	1
L:L:F7	R:R:F208	3.22	0	No	Yes	0	7	0	1
L:L:W8	R:R:F208	8.02	1	No	Yes	0	7	0	1
L:L:W8	R:R:T212	3.64	1	No	No	0	4	0	1
L:L:K9	R:R:D122	11.06	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:Q126	8.14	1	Yes	Yes	0	7	0	1
L:L:K9	R:R:Y302	4.78	1	Yes	Yes	0	7	0	1
L:L:F11	R:R:K291	13.65	0	No	No	0	3	0	1
L:L:T12	R:R:R184	5.17	0	Yes	Yes	0	2	0	1
L:L:T12	R:R:S192	3.2	0	Yes	No	0	4	0	1
L:L:T12	R:R:T194	3.14	0	Yes	No	0	4	0	1
L:L:S13	R:R:R190	9.22	3	No	Yes	0	1	0	1
L:L:C14	R:R:R184	5.57	3	Yes	Yes	0	2	0	1
L:L:C14	R:R:N186	6.3	3	Yes	No	0	1	0	1
L:L:C14	R:R:R190	6.96	3	Yes	Yes	0	1	0	1
R:R:D122	R:R:F92	5.97	1	Yes	Yes	6	6	1	2
R:R:F92	R:R:Q126	12.88	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	12.38	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	11.72	0	Yes	Yes	7	7	2	1
R:R:Q102	R:R:S192	8.66	0	No	No	5	4	2	1
R:R:D122	R:R:G123	3.35	1	Yes	No	6	4	1	2
R:R:D122	R:R:Q126	3.92	1	Yes	Yes	6	7	1	1
R:R:D122	R:R:Y302	5.75	1	Yes	Yes	6	7	1	1
R:R:F127	R:R:Q126	3.51	0	No	Yes	6	7	2	1
R:R:Q126	R:R:W269	8.76	1	Yes	Yes	7	8	1	2
R:R:F208	R:R:I177	3.77	1	Yes	No	7	3	1	2
R:R:N186	R:R:R184	7.23	3	No	Yes	1	2	1	1
R:R:N186	R:R:R190	12.05	3	No	Yes	1	1	1	1
R:R:R190	R:R:W188	5	3	Yes	No	1	2	1	2
R:R:N196	R:R:T194	2.92	0	No	No	3	4	2	1
R:R:N196	R:R:Y205	11.63	0	No	Yes	3	4	2	1
R:R:F208	R:R:T212	7.78	1	Yes	No	7	4	1	1
R:R:T212	R:R:Y273	4.99	1	No	No	4	7	1	2
R:R:F294	R:R:V298	2.62	0	No	No	4	6	1	2
R:R:P286	R:R:S285	1.78	0	No	No	2	2	1	2
R:R:G292	R:R:K291	1.74	0	No	No	1	3	2	1
R:R:G202	R:R:Y205	1.45	0	No	Yes	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y27_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	251
Number of Links	261
Number of Hubs	23
Number of Links mediated by Hubs	83
Number of Communities	6
Number of Nodes involved in Communities	31
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	37328
Length Of Smallest Path	3
Average Path Length	17.9686
Length of Longest Path	41
Minimum Path Strength	1.24
Average Path Strength	5.90762
Maximum Path Strength	17.68
Minimum Path Correlation	0.7
Average Path Correlation	0.928254
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	40.4195
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.2817
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • binding • neuropeptide binding • peptide binding • protein binding • PDZ domain binding • protein domain specific binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to prostaglandin E • cellular response to ketone • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • response to acid chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • regulation of biological quality • somatostatin signaling pathway • hormone-mediated signaling pathway • somatostatin receptor signaling pathway • cell-cell signaling • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • response to osmotic stress • hyperosmotic response • response to stress • response to abiotic stimulus • cell surface receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient levels • response to nutrient • response to pH • response to acidic pH • multicellular organismal process • digestion • dense core granule • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • GABA-ergic synapse • somatodendritic compartment • cell body • neuronal cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Somatostatin-14
UniProt	P61278
Sequence	>7Y27_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7Y27_nogp_Chain_R L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V P A I S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

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