psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	12.1	Yes	No	1	0	0
2	L:L:?1	L:L:C7	5.38	Yes	Yes	1	0	0
3	L:L:?1	R:R:Q187	6.77	Yes	Yes	1	0	2
4	L:L:?1	R:R:P286	8.35	Yes	No	1	0	2
5	L:L:C2	L:L:C7	7.28	No	Yes	1	0	0
6	L:L:C2	R:R:F294	13.97	No	Yes	1	0	4
7	L:L:?4	L:L:F3	5.8	Yes	Yes	1	0	0
8	L:L:F3	R:R:Y205	14.44	Yes	No	0	0	4
9	L:L:F3	R:R:F208	7.5	Yes	Yes	1	0	7
10	L:L:?4	L:L:K5	22.39	Yes	Yes	0	0	0
11	L:L:?4	R:R:Q126	6.34	Yes	Yes	1	0	7
12	L:L:?4	R:R:F127	2.9	Yes	Yes	1	0	6
13	L:L:?4	R:R:I177	4.53	Yes	No	1	0	3
14	L:L:?4	R:R:F208	12.57	Yes	Yes	1	0	7
15	L:L:?4	R:R:T212	8.19	Yes	Yes	1	0	4
16	L:L:?4	R:R:F272	3.87	Yes	Yes	1	0	6
17	L:L:?4	R:R:N276	7.63	Yes	Yes	1	0	6
18	L:L:K5	R:R:L99	4.23	Yes	No	0	0	6
19	L:L:K5	R:R:V298	3.04	Yes	No	0	0	6
20	L:L:K5	R:R:Y302	7.17	Yes	Yes	0	0	7
21	L:L:T6	R:R:Q102	9.92	No	Yes	0	0	5
22	L:L:C7	R:R:Q187	3.05	Yes	Yes	1	0	2
23	L:L:C7	R:R:F294	5.59	Yes	Yes	1	0	4
24	R:R:N43	R:R:S42	7.45	No	No	0	3	4
25	R:R:K291	R:R:N43	5.6	Yes	No	0	3	3
26	R:R:F296	R:R:L46	12.18	No	No	0	5	5
27	R:R:A104	R:R:T47	5.03	No	No	0	5	5
28	R:R:F48	R:R:F51	3.22	No	No	0	6	5
29	R:R:I49	R:R:V299	3.07	No	No	0	5	5
30	R:R:L96	R:R:Y50	11.72	Yes	Yes	0	7	7
31	R:R:A100	R:R:Y50	5.34	No	Yes	0	6	7
32	R:R:D295	R:R:Y50	3.45	No	Yes	0	2	7
33	R:R:V298	R:R:Y50	3.79	No	Yes	0	6	7
34	R:R:V299	R:R:Y50	10.09	No	Yes	0	5	7
35	R:R:C54	R:R:F51	4.19	Yes	No	0	6	5
36	R:R:L96	R:R:V53	2.98	Yes	No	0	7	7
37	R:R:V299	R:R:V53	3.21	No	No	0	5	7
38	R:R:C54	R:R:M93	8.1	Yes	No	0	6	6
39	R:R:C54	R:R:L96	3.17	Yes	Yes	0	6	7
40	R:R:C54	R:R:P97	5.65	Yes	No	0	6	8
41	R:R:C306	R:R:I56	8.18	No	No	0	8	4
42	R:R:C306	R:R:G57	3.92	No	No	0	8	8
43	R:R:E90	R:R:L58	6.63	No	No	0	7	6
44	R:R:L58	R:R:M93	5.65	No	No	0	6	6
45	R:R:G60	R:R:L63	3.42	No	No	0	8	6
46	R:R:D89	R:R:N61	17.5	Yes	No	1	9	9
47	R:R:N61	R:R:P309	13.03	No	No	1	9	9
48	R:R:A86	R:R:V64	3.39	No	No	0	9	9
49	R:R:A313	R:R:V64	5.09	No	No	0	7	9
50	R:R:A86	R:R:I65	3.25	No	No	0	9	7
51	R:R:E90	R:R:I65	6.83	No	No	0	7	7
52	R:R:F319	R:R:V67	20.97	Yes	No	0	8	7
53	R:R:I68	R:R:N79	4.25	No	Yes	0	7	8
54	R:R:I68	R:R:L83	7.14	No	No	0	7	6
55	R:R:L69	R:R:M74	4.24	No	No	0	3	7
56	R:R:R70	R:R:Y71	4.12	No	No	0	4	6
57	R:R:V326	R:R:Y71	17.66	No	No	0	5	6
58	R:R:K73	R:R:T76	12.01	No	No	2	5	7
59	R:R:K73	R:R:N79	8.39	No	Yes	2	5	8
60	R:R:K75	R:R:M74	4.32	No	No	0	7	7
61	R:R:I80	R:R:K75	5.82	No	No	0	5	7
62	R:R:T76	R:R:T78	3.14	No	No	2	7	8
63	R:R:N79	R:R:T76	4.39	Yes	No	2	8	7
64	R:R:I77	R:R:R154	18.79	No	Yes	0	4	5
65	R:R:I77	R:R:P156	6.77	No	No	0	4	3
66	R:R:N79	R:R:T78	2.92	Yes	No	2	8	8
67	R:R:D139	R:R:T78	2.89	No	No	0	8	8
68	R:R:I82	R:R:N79	4.25	No	Yes	0	8	8
69	R:R:A159	R:R:I80	3.25	No	No	0	7	5
70	R:R:D139	R:R:Y81	8.05	No	No	0	8	7
71	R:R:A159	R:R:Y81	5.34	No	No	0	7	7
72	R:R:I162	R:R:Y81	8.46	No	No	0	5	7
73	R:R:I82	R:R:M136	7.29	No	No	0	8	9
74	R:R:C132	R:R:N84	3.15	No	No	0	8	9
75	R:R:N84	R:R:T163	13.16	No	No	0	9	7
76	R:R:N84	R:R:W167	6.78	No	No	0	9	9
77	R:R:C132	R:R:L85	7.94	No	No	0	8	9
78	R:R:L133	R:R:L85	4.15	No	No	1	9	9
79	R:R:L85	R:R:N308	8.24	No	Yes	1	9	9
80	R:R:A88	R:R:N125	3.13	No	No	0	8	7
81	R:R:D89	R:R:S305	11.78	Yes	No	0	9	8
82	R:R:D89	R:R:N308	4.04	Yes	Yes	1	9	9
83	R:R:D89	R:R:P309	4.83	Yes	No	1	9	9
84	R:R:L91	R:R:N125	12.36	No	No	0	7	7
85	R:R:D122	R:R:F92	11.94	No	Yes	1	6	6
86	R:R:F92	R:R:N125	6.04	Yes	No	0	6	7
87	R:R:F92	R:R:Q126	10.54	Yes	Yes	1	6	7
88	R:R:F92	R:R:Y302	24.76	Yes	Yes	1	6	7
89	R:R:D122	R:R:G95	5.03	No	No	0	6	6
90	R:R:L96	R:R:Y302	16.41	Yes	Yes	0	7	7
91	R:R:F98	R:R:W108	4.01	No	Yes	0	5	8
92	R:R:F98	R:R:V118	15.73	No	No	0	5	5
93	R:R:Q102	R:R:V103	4.3	Yes	Yes	0	5	4
94	R:R:Q102	R:R:W108	9.86	Yes	Yes	0	5	8
95	R:R:K291	R:R:V103	6.07	Yes	Yes	5	3	4
96	R:R:D295	R:R:V103	11.69	No	Yes	5	2	4
97	R:R:K291	R:R:V106	4.55	Yes	No	0	3	4
98	R:R:P109	R:R:W108	25.67	No	Yes	0	4	8
99	R:R:G111	R:R:W108	4.22	No	Yes	3	7	8
100	R:R:C115	R:R:W108	10.45	No	Yes	3	9	8
101	R:R:C193	R:R:W108	16.98	No	Yes	3	9	8
102	R:R:F110	R:R:K112	9.93	No	No	0	6	3
103	R:R:F110	R:R:I114	3.77	No	No	0	6	6
104	R:R:C115	R:R:G111	3.92	No	No	3	9	7
105	R:R:C115	R:R:C193	3.64	No	No	3	9	9
106	R:R:A181	R:R:R116	5.53	No	No	0	4	6
107	R:R:I177	R:R:M119	2.92	No	No	0	3	5
108	R:R:D122	R:R:Y302	5.75	No	Yes	1	6	7
109	R:R:I124	R:R:L171	4.28	No	No	0	5	3
110	R:R:I124	R:R:I174	5.89	No	No	0	5	7
111	R:R:F127	R:R:Q126	9.37	Yes	Yes	1	6	7
112	R:R:Q126	R:R:W269	9.86	Yes	Yes	1	7	8
113	R:R:F127	R:R:T212	5.19	Yes	Yes	1	6	4
114	R:R:F127	R:R:G216	4.52	Yes	No	0	6	6
115	R:R:T128	R:R:V166	4.76	No	No	0	7	6
116	R:R:T128	R:R:W167	12.13	No	No	0	7	9
117	R:R:S170	R:R:T128	7.99	No	No	0	7	7
118	R:R:S129	R:R:S305	3.26	No	No	0	9	8
119	R:R:C132	R:R:V135	3.42	No	No	0	8	7
120	R:R:L133	R:R:N308	10.98	No	Yes	1	9	9
121	R:R:L133	R:R:Y312	5.86	No	Yes	1	9	9
122	R:R:P220	R:R:T134	3.5	No	No	0	9	7
123	R:R:I223	R:R:T134	4.56	No	No	0	6	7
124	R:R:M136	R:R:Y312	5.99	No	Yes	0	9	9
125	R:R:I224	R:R:S137	7.74	No	No	0	7	9
126	R:R:C227	R:R:S137	3.44	No	No	0	7	9
127	R:R:S137	R:R:Y228	8.9	No	Yes	0	9	9
128	R:R:I138	R:R:I223	2.94	No	No	0	6	6
129	R:R:D139	R:R:R154	9.53	No	Yes	0	8	5
130	R:R:R140	R:R:Y228	12.35	No	Yes	1	9	9
131	R:R:R140	R:R:Y312	9.26	No	Yes	1	9	9
132	R:R:L142	R:R:Y141	3.52	No	Yes	0	4	8
133	R:R:V145	R:R:Y141	11.36	No	Yes	6	7	8
134	R:R:H146	R:R:Y141	7.62	Yes	Yes	6	5	8
135	R:R:C227	R:R:Y141	8.06	No	Yes	0	7	8
136	R:R:F230	R:R:Y141	6.19	No	Yes	0	4	8
137	R:R:A143	R:R:R154	5.53	No	Yes	0	8	5
138	R:R:I231	R:R:V144	6.14	No	No	0	9	8
139	R:R:H146	R:R:V145	5.54	Yes	No	6	5	7
140	R:R:K234	R:R:V145	4.55	No	No	0	5	7
141	R:R:I148	R:R:K149	4.36	No	No	0	5	4
142	R:R:R154	R:R:S150	5.27	Yes	No	0	5	5
143	R:R:R155	R:R:R157	6.4	No	No	0	6	4
144	R:R:K160	R:R:R157	7.43	No	No	0	1	4
145	R:R:M161	R:R:T158	4.52	No	No	0	1	5
146	R:R:K160	R:R:M164	4.32	No	No	0	1	4
147	R:R:V173	R:R:Y211	6.31	No	No	1	4	4
148	R:R:L215	R:R:V173	2.98	No	No	1	4	4
149	R:R:L175	R:R:P176	4.93	No	No	0	4	8
150	R:R:F208	R:R:I177	5.02	Yes	No	1	7	3
151	R:R:I179	R:R:Y180	8.46	No	No	0	4	4
152	R:R:I195	R:R:Y180	3.63	No	No	0	5	4
153	R:R:P198	R:R:Y180	11.13	No	No	0	5	4
154	R:R:G182	R:R:N196	6.79	No	No	0	5	3
155	R:R:L183	R:R:S191	9.01	No	No	0	4	5
156	R:R:N196	R:R:R184	12.05	No	No	0	3	2
157	R:R:R184	R:R:W197	13	No	No	0	2	5
158	R:R:S185	R:R:S191	6.52	No	No	0	2	5
159	R:R:N186	R:R:Q187	6.6	No	Yes	0	1	2
160	R:R:Q187	R:R:W188	16.43	Yes	No	0	2	2
161	R:R:P286	R:R:Q187	3.16	No	Yes	1	2	2
162	R:R:I195	R:R:T194	3.04	No	No	0	5	4
163	R:R:W197	R:R:Y205	8.68	No	No	0	5	4
164	R:R:T206	R:R:V280	4.76	No	No	0	3	4
165	R:R:G207	R:R:I210	3.53	No	No	0	4	5
166	R:R:F208	R:R:I209	3.77	Yes	Yes	1	7	5
167	R:R:F208	R:R:T212	5.19	Yes	Yes	1	7	4
168	R:R:I209	R:R:T212	3.04	Yes	Yes	1	5	4
169	R:R:I209	R:R:N276	11.33	Yes	Yes	1	5	6
170	R:R:L215	R:R:Y211	3.52	No	No	1	4	4
171	R:R:T212	R:R:Y273	8.74	Yes	No	0	4	7
172	R:R:F213	R:R:L218	9.74	No	No	0	5	4
173	R:R:I214	R:R:L215	9.99	No	No	0	4	4
174	R:R:I214	R:R:V219	4.61	No	No	0	4	5
175	R:R:F217	R:R:I266	6.28	Yes	No	1	8	6
176	R:R:F217	R:R:L270	4.87	Yes	Yes	1	8	5
177	R:R:F217	R:R:Y273	6.19	Yes	No	0	8	7
178	R:R:P220	R:R:V219	3.53	No	No	0	9	5
179	R:R:C225	R:R:L221	3.17	No	Yes	1	5	6
180	R:R:L221	R:R:V262	2.98	Yes	No	1	6	7
181	R:R:F265	R:R:L221	7.31	No	Yes	0	9	6
182	R:R:I223	R:R:T222	3.04	No	No	0	6	4
183	R:R:C225	R:R:V262	5.12	No	No	1	5	7
184	R:R:V258	R:R:Y228	6.31	Yes	Yes	1	8	9
185	R:R:Y228	R:R:Y312	4.96	Yes	Yes	1	9	9
186	R:R:I232	R:R:T255	7.6	No	No	1	5	7
187	R:R:I232	R:R:V258	6.14	No	Yes	1	5	8
188	R:R:K234	R:R:S237	7.65	No	No	0	5	5
189	R:R:K236	R:R:S237	3.06	Yes	No	0	4	5
190	R:R:I240	R:R:K236	8.72	No	Yes	4	3	4
191	R:R:E251	R:R:K236	6.75	Yes	Yes	4	6	4
192	R:R:G239	R:R:S238	3.71	No	No	0	5	5
193	R:R:I240	R:R:K248	15.99	No	No	4	3	3
194	R:R:E251	R:R:I240	5.47	Yes	No	4	6	3
195	R:R:R241	R:R:V242	3.92	No	No	0	1	3
196	R:R:G243	R:R:S244	3.71	No	No	0	1	3
197	R:R:K249	R:R:R247	9.9	No	No	0	4	4
198	R:R:E251	R:R:K248	5.4	Yes	No	4	6	3
199	R:R:K249	R:R:K253	10.06	No	No	0	4	7
200	R:R:E251	R:R:S250	4.31	Yes	No	0	6	5
201	R:R:T255	R:R:V258	3.17	No	Yes	1	7	8
202	R:R:L315	R:R:M257	4.24	No	No	0	6	8
203	R:R:L311	R:R:V261	4.47	No	No	0	8	8
204	R:R:L311	R:R:V264	2.98	No	No	0	8	7
205	R:R:I266	R:R:L270	5.71	No	Yes	1	6	5
206	R:R:C268	R:R:W269	9.14	No	Yes	1	8	8
207	R:R:C268	R:R:N304	4.72	No	No	1	8	9
208	R:R:F272	R:R:W269	3.01	Yes	Yes	1	6	8
209	R:R:W269	R:R:Y273	3.86	Yes	No	0	8	7
210	R:R:T301	R:R:W269	19.41	No	Yes	1	7	8
211	R:R:N304	R:R:W269	9.04	No	Yes	1	9	8
212	R:R:L270	R:R:P271	3.28	Yes	No	1	5	9
213	R:R:I274	R:R:L270	5.71	No	Yes	0	5	5
214	R:R:P271	R:R:V297	3.53	No	Yes	1	9	7
215	R:R:L300	R:R:P271	3.28	No	No	1	7	9
216	R:R:F272	R:R:N276	3.62	Yes	Yes	1	6	6
217	R:R:F272	R:R:V297	3.93	Yes	Yes	1	6	7
218	R:R:F272	R:R:T301	5.19	Yes	No	1	6	7
219	R:R:F275	R:R:M293	8.71	No	No	0	4	4
220	R:R:F275	R:R:F294	6.43	No	Yes	0	4	4
221	R:R:F275	R:R:V297	6.55	No	Yes	0	4	7
222	R:R:F294	R:R:N276	8.46	Yes	Yes	1	4	6
223	R:R:M282	R:R:S278	3.07	No	No	0	3	4
224	R:R:M282	R:R:S281	3.07	No	No	0	3	4
225	R:R:P288	R:R:T287	5.25	No	No	0	3	1
226	R:R:L290	R:R:T287	8.84	No	No	0	4	1
227	R:R:D295	R:R:K291	9.68	No	Yes	5	2	3
228	R:R:L300	R:R:V297	2.98	No	Yes	1	7	7
229	R:R:T301	R:R:Y302	3.75	No	Yes	1	7	7
230	R:R:N304	R:R:N308	9.54	No	Yes	1	9	9
231	R:R:F314	R:R:I310	7.54	No	No	0	7	6
232	R:R:L311	R:R:Y312	4.69	No	Yes	0	8	9
233	R:R:F314	R:R:F323	3.22	No	No	0	7	6
234	R:R:N318	R:R:S322	10.43	No	No	0	5	5
235	R:R:F319	R:R:F323	9.65	Yes	No	0	8	6
236	R:R:K320	R:R:K321	7.18	No	No	0	8	5
237	R:R:K321	R:R:Q324	6.78	No	No	0	5	4
238	R:R:I266	R:R:L221	2.85	No	Yes	1	6	6
239	R:R:E251	R:R:V235	2.85	Yes	No	0	6	8
240	R:R:I284	R:R:L290	2.85	No	No	0	1	4
241	R:R:A313	R:R:F319	2.77	No	Yes	0	7	8
242	R:R:F319	R:R:S322	2.64	Yes	No	0	8	5
243	L:L:F3	R:R:V280	2.62	Yes	No	0	0	4
244	R:R:F127	R:R:V173	2.62	Yes	No	1	6	4
245	R:R:F131	R:R:V166	2.62	No	No	0	6	6
246	R:R:H146	R:R:K149	2.62	Yes	No	0	5	4
247	L:L:?1	R:R:S279	2.54	Yes	No	0	0	4
248	L:L:F3	R:R:I195	2.51	Yes	No	0	0	5
249	R:R:F265	R:R:I130	2.51	No	No	0	9	8
250	R:R:M161	R:R:R157	2.48	No	No	0	1	4
251	R:R:K236	R:R:R241	2.48	Yes	No	0	4	1
252	R:R:F319	R:R:L63	2.44	Yes	No	0	8	6
253	L:L:?1	R:R:I284	2.42	Yes	No	0	0	1
254	R:R:I231	R:R:Y228	2.42	No	Yes	0	9	9
255	R:R:I87	R:R:W167	2.35	No	No	0	7	9
256	R:R:H107	R:R:R190	2.26	No	No	0	4	1
257	R:R:F213	R:R:F217	2.14	No	Yes	0	5	8
258	R:R:F110	R:R:W108	2	No	Yes	0	6	8
259	R:R:G189	R:R:S185	1.86	No	No	0	6	2
260	R:R:G239	R:R:S244	1.86	No	No	0	5	3
261	R:R:G243	R:R:V242	1.84	No	No	0	1	3
262	R:R:G207	R:R:T206	1.82	No	No	0	4	3
263	R:R:P286	R:R:S285	1.78	No	No	0	2	2
264	R:R:G123	R:R:I174	1.76	No	No	0	4	7
265	R:R:G57	R:R:M93	1.75	No	No	0	8	6
266	R:R:G292	R:R:L46	1.71	No	No	0	1	5
267	R:R:G111	R:R:L183	1.71	No	No	0	7	4
268	R:R:A151	R:R:S150	1.71	No	No	0	4	5
269	R:R:A307	R:R:V264	1.7	No	No	0	6	7
270	R:R:M101	R:R:P109	1.68	No	No	0	5	4
271	R:R:A289	R:R:T287	1.68	No	No	0	1	1
272	R:R:L94	R:R:P97	1.64	No	No	0	5	8
273	R:R:G123	R:R:Q126	1.64	No	Yes	0	4	7
274	R:R:A72	R:R:M74	1.61	No	No	0	5	7
275	R:R:V52	R:R:V53	1.6	No	No	0	5	7
276	R:R:T41	R:R:V45	1.59	No	No	0	4	5
277	R:R:T47	R:R:V103	1.59	No	Yes	0	5	4
278	R:R:T120	R:R:V117	1.59	No	No	0	6	5
279	R:R:A104	R:R:L105	1.58	No	No	0	5	5
280	R:R:I82	R:R:S316	1.55	No	No	0	8	8
281	R:R:I55	R:R:V52	1.54	No	No	0	4	5
282	R:R:I114	R:R:V117	1.54	No	No	0	6	5
283	R:R:I124	R:R:V121	1.54	No	No	0	5	5
284	R:R:I209	R:R:V277	1.54	Yes	No	0	5	5
285	R:R:I260	R:R:V264	1.54	No	No	0	6	7
286	R:R:H107	R:R:P109	1.53	No	No	0	4	4
287	R:R:H146	R:R:P147	1.53	Yes	No	0	5	8
288	R:R:I65	R:R:T62	1.52	No	No	0	7	5
289	R:R:M257	R:R:V258	1.52	No	Yes	0	8	8
290	R:R:M178	R:R:T120	1.51	No	No	0	5	6
291	R:R:K160	R:R:T163	1.5	No	No	0	1	7
292	R:R:L46	R:R:V45	1.49	No	No	0	5	5
293	R:R:N325	R:R:V326	1.48	No	No	0	4	5
294	R:R:Q102	R:R:S192	1.44	Yes	No	0	5	4
295	R:R:K246	R:R:K248	1.44	No	No	0	3	3
296	R:R:L175	R:R:M178	1.41	No	No	0	4	5
297	R:R:P198	R:R:W204	1.35	No	No	0	5	3
298	R:R:E251	R:R:K252	1.35	Yes	No	0	6	5
299	R:R:D317	R:R:N318	1.35	No	No	0	5	5
300	R:R:R247	R:R:S245	1.32	No	No	0	4	2
301	R:R:R247	R:R:S250	1.32	No	No	0	4	5
302	R:R:F296	R:R:I49	1.26	No	No	0	5	5
303	R:R:F230	R:R:I233	1.26	No	No	0	4	3
304	R:R:T62	R:R:Y66	1.25	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.26	6	1	0
2	L:L:F3	6.574	5	1	0
3	L:L:?4	8.24667	9	1	0
4	L:L:K5	9.2075	4	0	0
5	L:L:C7	5.325	4	1	0
6	R:R:Y50	6.878	5	0	7
7	R:R:C54	5.2775	4	0	6
8	R:R:N79	4.84	5	2	8
9	R:R:D89	9.5375	4	1	9
10	R:R:F92	13.32	4	1	6
11	R:R:L96	8.57	4	0	7
12	R:R:Q102	6.38	4	0	5
13	R:R:V103	5.9125	4	5	4
14	R:R:W108	10.4557	7	3	8
15	R:R:Q126	7.55	5	1	7
16	R:R:F127	4.92	5	1	6
17	R:R:Y141	7.35	5	6	8
18	R:R:H146	4.3275	4	6	5
19	R:R:R154	9.78	4	0	5
20	R:R:Q187	7.202	5	1	2
21	R:R:F208	6.81	5	1	7
22	R:R:I209	4.92	4	1	5
23	R:R:T212	6.07	5	1	4
24	R:R:F217	4.87	4	1	8
25	R:R:L221	4.0775	4	1	6
26	R:R:Y228	6.988	5	1	9
27	R:R:K236	5.2525	4	4	4
28	R:R:E251	4.355	6	4	6
29	R:R:V258	4.285	4	1	8
30	R:R:W269	9.05333	6	1	8
31	R:R:L270	4.8925	4	1	5
32	R:R:F272	3.924	5	1	6
33	R:R:N276	7.76	4	1	6
34	R:R:K291	6.475	4	5	3
35	R:R:F294	8.6125	4	1	4
36	R:R:V297	4.2475	4	1	7
37	R:R:Y302	11.568	5	1	7
38	R:R:N308	8.2	4	1	9
39	R:R:Y312	6.152	5	1	9
40	R:R:F319	7.694	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	13.0055	12.1	Yes	No	1	0	0
2	L:L:C2	R:R:F294	14.3812	13.97	No	Yes	1	0	4
3	L:L:?1	L:L:C7	12.9909	5.38	Yes	Yes	1	0	0
4	L:L:C7	R:R:F294	21.4596	5.59	Yes	Yes	1	0	4
5	R:R:F294	R:R:N276	35.9627	8.46	Yes	Yes	1	4	6
6	L:L:?4	R:R:N276	18.6253	7.63	Yes	Yes	1	0	6
7	L:L:?4	L:L:F3	27.7575	5.8	Yes	Yes	1	0	0
8	L:L:?4	L:L:K5	34.4846	22.39	Yes	Yes	0	0	0
9	L:L:?4	R:R:Q126	15.9471	6.34	Yes	Yes	1	0	7
10	R:R:F272	R:R:N276	19.8449	3.62	Yes	Yes	1	6	6
11	L:L:K5	R:R:V298	21.845	3.04	Yes	No	0	0	6
12	L:L:K5	R:R:Y302	12.586	7.17	Yes	Yes	0	0	7
13	R:R:T301	R:R:Y302	55.8515	3.75	No	Yes	1	7	7
14	R:R:V298	R:R:Y50	20.2839	3.79	No	Yes	0	6	7
15	R:R:D295	R:R:Y50	45.1632	3.45	No	Yes	0	2	7
16	R:R:D295	R:R:V103	38.7677	11.69	No	Yes	5	2	4
17	R:R:Q102	R:R:V103	34.4553	4.3	Yes	Yes	0	5	4
18	R:R:V299	R:R:Y50	10.6103	10.09	No	Yes	0	5	7
19	R:R:I49	R:R:V299	13.4885	3.07	No	No	0	5	5
20	R:R:F296	R:R:I49	11.264	1.26	No	No	0	5	5
21	R:R:L96	R:R:Y302	69.2961	16.41	Yes	Yes	0	7	7
22	R:R:C54	R:R:L96	39.1629	3.17	Yes	Yes	0	6	7
23	R:R:L96	R:R:V53	10.0346	2.98	Yes	No	0	7	7
24	R:R:C54	R:R:M93	32.4309	8.1	Yes	No	0	6	6
25	R:R:L58	R:R:M93	26.8696	5.65	No	No	0	6	6
26	R:R:E90	R:R:L58	25.4549	6.63	No	No	0	7	6
27	R:R:E90	R:R:I65	24.0304	6.83	No	No	0	7	7
28	R:R:A86	R:R:I65	19.7815	3.25	No	No	0	9	7
29	R:R:A86	R:R:V64	18.318	3.39	No	No	0	9	9
30	R:R:A313	R:R:V64	16.8447	5.09	No	No	0	7	9
31	R:R:A313	R:R:F319	15.3617	2.77	No	Yes	0	7	8
32	R:R:F272	R:R:W269	29.0843	3.01	Yes	Yes	1	6	8
33	R:R:N304	R:R:W269	100	9.04	No	Yes	1	9	8
34	R:R:N304	R:R:N308	99.922	9.54	No	Yes	1	9	9
35	R:R:L133	R:R:N308	78.3014	10.98	No	Yes	1	9	9
36	R:R:L133	R:R:Y312	83.648	5.86	No	Yes	1	9	9
37	R:R:M136	R:R:Y312	33.3431	5.99	No	Yes	0	9	9
38	R:R:I82	R:R:M136	32.0845	7.29	No	No	0	8	9
39	R:R:I82	R:R:N79	29.4941	4.25	No	Yes	0	8	8
40	R:R:N79	R:R:T78	22.7816	2.92	Yes	No	2	8	8
41	R:R:D139	R:R:T78	21.5669	2.89	No	No	0	8	8
42	R:R:D139	R:R:Y81	11.7713	8.05	No	No	0	8	7
43	R:R:L85	R:R:N308	18.0741	8.24	No	Yes	1	9	9
44	R:R:C132	R:R:L85	22.8645	7.94	No	No	0	8	9
45	R:R:C132	R:R:N84	20.1424	3.15	No	No	0	8	9
46	R:R:N84	R:R:T163	10.3078	13.16	No	No	0	9	7
47	R:R:F92	R:R:Q126	10.0102	10.54	Yes	Yes	1	6	7
48	R:R:Q102	R:R:W108	30.6893	9.86	Yes	Yes	0	5	8
49	R:R:F110	R:R:W108	11.703	2	No	Yes	0	6	8
50	R:R:F127	R:R:V173	14.4446	2.62	Yes	No	1	6	4
51	R:R:L215	R:R:V173	11.625	2.98	No	No	1	4	4
52	R:R:I214	R:R:L215	10.2395	9.99	No	No	0	4	4
53	R:R:Y228	R:R:Y312	54.1441	4.96	Yes	Yes	1	9	9
54	R:R:S137	R:R:Y228	45.4315	8.9	No	Yes	0	9	9
55	R:R:C227	R:R:S137	43.0606	3.44	No	No	0	7	9
56	R:R:C227	R:R:Y141	41.8606	8.06	No	Yes	0	7	8
57	R:R:V145	R:R:Y141	31.4601	11.36	No	Yes	6	7	8
58	R:R:K234	R:R:V145	30.6161	4.55	No	No	0	5	7
59	L:L:F3	R:R:I195	11.1518	2.51	Yes	No	0	0	5
60	R:R:W269	R:R:Y273	14.108	3.86	Yes	No	0	8	7
61	R:R:F217	R:R:Y273	17.2643	6.19	Yes	No	0	8	7
62	R:R:K234	R:R:S237	29.4063	7.65	No	No	0	5	5
63	R:R:K236	R:R:S237	28.0989	3.06	Yes	No	0	4	5
64	R:R:E251	R:R:K236	14.3373	6.75	Yes	Yes	4	6	4
65	L:L:?1	R:R:I284	14.6056	2.42	Yes	No	0	0	1
66	R:R:I284	R:R:L290	11.703	2.85	No	No	0	1	4
67	R:R:Q126	R:R:W269	23.8841	9.86	Yes	Yes	1	7	8
68	L:L:?4	R:R:F272	14.4788	3.87	Yes	Yes	1	0	6
69	R:R:T301	R:R:W269	47.8462	19.41	No	Yes	1	7	8
70	R:R:L96	R:R:Y50	34.5578	11.72	Yes	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q187	6.77	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:P286	8.35	1	Yes	No	0	2	0	1
L:L:C2	R:R:F294	13.97	1	No	Yes	0	4	0	1
L:L:F3	R:R:Y205	14.44	1	Yes	No	0	4	0	1
L:L:F3	R:R:F208	7.5	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:Q126	6.34	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:F127	2.9	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:I177	4.53	1	Yes	No	0	3	0	1
L:L:?4	R:R:F208	12.57	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:T212	8.19	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:F272	3.87	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N276	7.63	1	Yes	Yes	0	6	0	1
L:L:K5	R:R:L99	4.23	0	Yes	No	0	6	0	1
L:L:K5	R:R:V298	3.04	0	Yes	No	0	6	0	1
L:L:K5	R:R:Y302	7.17	0	Yes	Yes	0	7	0	1
L:L:T6	R:R:Q102	9.92	0	No	Yes	0	5	0	1
L:L:C7	R:R:Q187	3.05	1	Yes	Yes	0	2	0	1
L:L:C7	R:R:F294	5.59	1	Yes	Yes	0	4	0	1
R:R:L96	R:R:Y50	11.72	0	Yes	Yes	7	7	2	2
R:R:V298	R:R:Y50	3.79	0	No	Yes	6	7	1	2
R:R:D122	R:R:F92	11.94	1	No	Yes	6	6	2	2
R:R:F92	R:R:Q126	10.54	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	24.76	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	16.41	0	Yes	Yes	7	7	2	1
R:R:Q102	R:R:V103	4.3	0	Yes	Yes	5	4	1	2
R:R:Q102	R:R:W108	9.86	0	Yes	Yes	5	8	1	2
R:R:I177	R:R:M119	2.92	1	No	No	3	5	1	2
R:R:D122	R:R:Y302	5.75	1	No	Yes	6	7	2	1
R:R:F127	R:R:Q126	9.37	1	Yes	Yes	6	7	1	1
R:R:Q126	R:R:W269	9.86	1	Yes	Yes	7	8	1	2
R:R:F127	R:R:T212	5.19	1	Yes	Yes	6	4	1	1
R:R:F127	R:R:G216	4.52	1	Yes	No	6	6	1	2
R:R:F208	R:R:I177	5.02	1	Yes	No	7	3	1	1
R:R:I195	R:R:Y180	3.63	0	No	No	5	4	1	2
R:R:N186	R:R:Q187	6.6	0	No	Yes	1	2	2	1
R:R:Q187	R:R:W188	16.43	1	Yes	No	2	2	1	2
R:R:P286	R:R:Q187	3.16	1	No	Yes	2	2	1	1
R:R:I195	R:R:T194	3.04	0	No	No	5	4	1	2
R:R:W197	R:R:Y205	8.68	0	No	No	5	4	2	1
R:R:T206	R:R:V280	4.76	0	No	No	3	4	2	1
R:R:F208	R:R:I209	3.77	1	Yes	Yes	7	5	1	2
R:R:F208	R:R:T212	5.19	1	Yes	Yes	7	4	1	1
R:R:I209	R:R:T212	3.04	1	Yes	Yes	5	4	2	1
R:R:I209	R:R:N276	11.33	1	Yes	Yes	5	6	2	1
R:R:T212	R:R:Y273	8.74	1	Yes	No	4	7	1	2
R:R:F272	R:R:W269	3.01	1	Yes	Yes	6	8	1	2
R:R:W269	R:R:Y273	3.86	1	Yes	No	8	7	2	2
R:R:T301	R:R:W269	19.41	1	No	Yes	7	8	2	2
R:R:F272	R:R:N276	3.62	1	Yes	Yes	6	6	1	1
R:R:F272	R:R:V297	3.93	1	Yes	Yes	6	7	1	2
R:R:F272	R:R:T301	5.19	1	Yes	No	6	7	1	2
R:R:F275	R:R:F294	6.43	0	No	Yes	4	4	2	1
R:R:F275	R:R:V297	6.55	0	No	Yes	4	7	2	2
R:R:F294	R:R:N276	8.46	1	Yes	Yes	4	6	1	1
R:R:T301	R:R:Y302	3.75	1	No	Yes	7	7	2	1
R:R:I284	R:R:L290	2.85	0	No	No	1	4	1	2
L:L:F3	R:R:V280	2.62	1	Yes	No	0	4	0	1
R:R:F127	R:R:V173	2.62	1	Yes	No	6	4	1	2
L:L:?1	R:R:S279	2.54	1	Yes	No	0	4	0	1
L:L:F3	R:R:I195	2.51	1	Yes	No	0	5	0	1
L:L:?1	R:R:I284	2.42	1	Yes	No	0	1	0	1
R:R:P286	R:R:S285	1.78	1	No	No	2	2	1	2
R:R:G123	R:R:Q126	1.64	0	No	Yes	4	7	2	1
R:R:Q102	R:R:S192	1.44	0	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XAU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	270
Number of Links	304
Number of Hubs	40
Number of Links mediated by Hubs	149
Number of Communities	6
Number of Nodes involved in Communities	65
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	44342
Length Of Smallest Path	3
Average Path Length	13.6071
Length of Longest Path	34
Minimum Path Strength	1.32
Average Path Strength	6.97709
Maximum Path Strength	21.325
Minimum Path Correlation	0.7
Average Path Correlation	0.93081
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	51.82
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9806
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cerebellum development • metencephalon development • hindbrain development • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	6919011
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid DTR D-Tryptophan (R)-tryptophan
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7XAU_nogp_Chain_R T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

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Download 7XAU_nogp.zip

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