Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 6.26610
2L:L:F3 6.574510
3L:L:?4 8.24667910
4L:L:K5 9.2075400
5L:L:C7 5.325410
6R:R:Y50 6.878507
7R:R:C54 5.2775406
8R:R:N79 4.84528
9R:R:D89 9.5375419
10R:R:F92 13.32416
11R:R:L96 8.57407
12R:R:Q102 6.38405
13R:R:V103 5.9125454
14R:R:W108 10.4557738
15R:R:Q126 7.55517
16R:R:F127 4.92516
17R:R:Y141 7.35568
18R:R:H146 4.3275465
19R:R:R154 9.78405
20R:R:Q187 7.202512
21R:R:F208 6.81517
22R:R:I209 4.92415
23R:R:T212 6.07514
24R:R:F217 4.87418
25R:R:L221 4.0775416
26R:R:Y228 6.988519
27R:R:K236 5.2525444
28R:R:E251 4.355646
29R:R:V258 4.285418
30R:R:W269 9.05333618
31R:R:L270 4.8925415
32R:R:F272 3.924516
33R:R:N276 7.76416
34R:R:K291 6.475453
35R:R:F294 8.6125414
36R:R:V297 4.2475417
37R:R:Y302 11.568517
38R:R:N308 8.2419
39R:R:Y312 6.152519
40R:R:F319 7.694508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 L:L:C2 13.005512.1YesNo100
2L:L:C2 R:R:F294 14.381213.97NoYes104
3L:L:?1 L:L:C7 12.99095.38YesYes100
4L:L:C7 R:R:F294 21.45965.59YesYes104
5R:R:F294 R:R:N276 35.96278.46YesYes146
6L:L:?4 R:R:N276 18.62537.63YesYes106
7L:L:?4 L:L:F3 27.75755.8YesYes100
8L:L:?4 L:L:K5 34.484622.39YesYes000
9L:L:?4 R:R:Q126 15.94716.34YesYes107
10R:R:F272 R:R:N276 19.84493.62YesYes166
11L:L:K5 R:R:V298 21.8453.04YesNo006
12L:L:K5 R:R:Y302 12.5867.17YesYes007
13R:R:T301 R:R:Y302 55.85153.75NoYes177
14R:R:V298 R:R:Y50 20.28393.79NoYes067
15R:R:D295 R:R:Y50 45.16323.45NoYes027
16R:R:D295 R:R:V103 38.767711.69NoYes524
17R:R:Q102 R:R:V103 34.45534.3YesYes054
18R:R:V299 R:R:Y50 10.610310.09NoYes057
19R:R:I49 R:R:V299 13.48853.07NoNo055
20R:R:F296 R:R:I49 11.2641.26NoNo055
21R:R:L96 R:R:Y302 69.296116.41YesYes077
22R:R:C54 R:R:L96 39.16293.17YesYes067
23R:R:L96 R:R:V53 10.03462.98YesNo077
24R:R:C54 R:R:M93 32.43098.1YesNo066
25R:R:L58 R:R:M93 26.86965.65NoNo066
26R:R:E90 R:R:L58 25.45496.63NoNo076
27R:R:E90 R:R:I65 24.03046.83NoNo077
28R:R:A86 R:R:I65 19.78153.25NoNo097
29R:R:A86 R:R:V64 18.3183.39NoNo099
30R:R:A313 R:R:V64 16.84475.09NoNo079
31R:R:A313 R:R:F319 15.36172.77NoYes078
32R:R:F272 R:R:W269 29.08433.01YesYes168
33R:R:N304 R:R:W269 1009.04NoYes198
34R:R:N304 R:R:N308 99.9229.54NoYes199
35R:R:L133 R:R:N308 78.301410.98NoYes199
36R:R:L133 R:R:Y312 83.6485.86NoYes199
37R:R:M136 R:R:Y312 33.34315.99NoYes099
38R:R:I82 R:R:M136 32.08457.29NoNo089
39R:R:I82 R:R:N79 29.49414.25NoYes088
40R:R:N79 R:R:T78 22.78162.92YesNo288
41R:R:D139 R:R:T78 21.56692.89NoNo088
42R:R:D139 R:R:Y81 11.77138.05NoNo087
43R:R:L85 R:R:N308 18.07418.24NoYes199
44R:R:C132 R:R:L85 22.86457.94NoNo089
45R:R:C132 R:R:N84 20.14243.15NoNo089
46R:R:N84 R:R:T163 10.307813.16NoNo097
47R:R:F92 R:R:Q126 10.010210.54YesYes167
48R:R:Q102 R:R:W108 30.68939.86YesYes058
49R:R:F110 R:R:W108 11.7032NoYes068
50R:R:F127 R:R:V173 14.44462.62YesNo164
51R:R:L215 R:R:V173 11.6252.98NoNo144
52R:R:I214 R:R:L215 10.23959.99NoNo044
53R:R:Y228 R:R:Y312 54.14414.96YesYes199
54R:R:S137 R:R:Y228 45.43158.9NoYes099
55R:R:C227 R:R:S137 43.06063.44NoNo079
56R:R:C227 R:R:Y141 41.86068.06NoYes078
57R:R:V145 R:R:Y141 31.460111.36NoYes678
58R:R:K234 R:R:V145 30.61614.55NoNo057
59L:L:F3 R:R:I195 11.15182.51YesNo005
60R:R:W269 R:R:Y273 14.1083.86YesNo087
61R:R:F217 R:R:Y273 17.26436.19YesNo087
62R:R:K234 R:R:S237 29.40637.65NoNo055
63R:R:K236 R:R:S237 28.09893.06YesNo045
64R:R:E251 R:R:K236 14.33736.75YesYes464
65L:L:?1 R:R:I284 14.60562.42YesNo001
66R:R:I284 R:R:L290 11.7032.85NoNo014
67R:R:Q126 R:R:W269 23.88419.86YesYes178
68L:L:?4 R:R:F272 14.47883.87YesYes106
69R:R:T301 R:R:W269 47.846219.41NoYes178
70R:R:L96 R:R:Y50 34.557811.72YesYes077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Q187 6.77 1 Yes Yes 0 2 0 1
L:L:?1 R:R:P286 8.35 1 Yes No 0 2 0 1
L:L:C2 R:R:F294 13.97 1 No Yes 0 4 0 1
L:L:F3 R:R:Y205 14.44 1 Yes No 0 4 0 1
L:L:F3 R:R:F208 7.5 1 Yes Yes 0 7 0 1
L:L:?4 R:R:Q126 6.34 1 Yes Yes 0 7 0 1
L:L:?4 R:R:F127 2.9 1 Yes Yes 0 6 0 1
L:L:?4 R:R:I177 4.53 1 Yes No 0 3 0 1
L:L:?4 R:R:F208 12.57 1 Yes Yes 0 7 0 1
L:L:?4 R:R:T212 8.19 1 Yes Yes 0 4 0 1
L:L:?4 R:R:F272 3.87 1 Yes Yes 0 6 0 1
L:L:?4 R:R:N276 7.63 1 Yes Yes 0 6 0 1
L:L:K5 R:R:L99 4.23 0 Yes No 0 6 0 1
L:L:K5 R:R:V298 3.04 0 Yes No 0 6 0 1
L:L:K5 R:R:Y302 7.17 0 Yes Yes 0 7 0 1
L:L:T6 R:R:Q102 9.92 0 No Yes 0 5 0 1
L:L:C7 R:R:Q187 3.05 1 Yes Yes 0 2 0 1
L:L:C7 R:R:F294 5.59 1 Yes Yes 0 4 0 1
R:R:L96 R:R:Y50 11.72 0 Yes Yes 7 7 2 2
R:R:V298 R:R:Y50 3.79 0 No Yes 6 7 1 2
R:R:D122 R:R:F92 11.94 1 No Yes 6 6 2 2
R:R:F92 R:R:Q126 10.54 1 Yes Yes 6 7 2 1
R:R:F92 R:R:Y302 24.76 1 Yes Yes 6 7 2 1
R:R:L96 R:R:Y302 16.41 0 Yes Yes 7 7 2 1
R:R:Q102 R:R:V103 4.3 0 Yes Yes 5 4 1 2
R:R:Q102 R:R:W108 9.86 0 Yes Yes 5 8 1 2
R:R:I177 R:R:M119 2.92 1 No No 3 5 1 2
R:R:D122 R:R:Y302 5.75 1 No Yes 6 7 2 1
R:R:F127 R:R:Q126 9.37 1 Yes Yes 6 7 1 1
R:R:Q126 R:R:W269 9.86 1 Yes Yes 7 8 1 2
R:R:F127 R:R:T212 5.19 1 Yes Yes 6 4 1 1
R:R:F127 R:R:G216 4.52 1 Yes No 6 6 1 2
R:R:F208 R:R:I177 5.02 1 Yes No 7 3 1 1
R:R:I195 R:R:Y180 3.63 0 No No 5 4 1 2
R:R:N186 R:R:Q187 6.6 0 No Yes 1 2 2 1
R:R:Q187 R:R:W188 16.43 1 Yes No 2 2 1 2
R:R:P286 R:R:Q187 3.16 1 No Yes 2 2 1 1
R:R:I195 R:R:T194 3.04 0 No No 5 4 1 2
R:R:W197 R:R:Y205 8.68 0 No No 5 4 2 1
R:R:T206 R:R:V280 4.76 0 No No 3 4 2 1
R:R:F208 R:R:I209 3.77 1 Yes Yes 7 5 1 2
R:R:F208 R:R:T212 5.19 1 Yes Yes 7 4 1 1
R:R:I209 R:R:T212 3.04 1 Yes Yes 5 4 2 1
R:R:I209 R:R:N276 11.33 1 Yes Yes 5 6 2 1
R:R:T212 R:R:Y273 8.74 1 Yes No 4 7 1 2
R:R:F272 R:R:W269 3.01 1 Yes Yes 6 8 1 2
R:R:W269 R:R:Y273 3.86 1 Yes No 8 7 2 2
R:R:T301 R:R:W269 19.41 1 No Yes 7 8 2 2
R:R:F272 R:R:N276 3.62 1 Yes Yes 6 6 1 1
R:R:F272 R:R:V297 3.93 1 Yes Yes 6 7 1 2
R:R:F272 R:R:T301 5.19 1 Yes No 6 7 1 2
R:R:F275 R:R:F294 6.43 0 No Yes 4 4 2 1
R:R:F275 R:R:V297 6.55 0 No Yes 4 7 2 2
R:R:F294 R:R:N276 8.46 1 Yes Yes 4 6 1 1
R:R:T301 R:R:Y302 3.75 1 No Yes 7 7 2 1
R:R:I284 R:R:L290 2.85 0 No No 1 4 1 2
L:L:F3 R:R:V280 2.62 1 Yes No 0 4 0 1
R:R:F127 R:R:V173 2.62 1 Yes No 6 4 1 2
L:L:?1 R:R:S279 2.54 1 Yes No 0 4 0 1
L:L:F3 R:R:I195 2.51 1 Yes No 0 5 0 1
L:L:?1 R:R:I284 2.42 1 Yes No 0 1 0 1
R:R:P286 R:R:S285 1.78 1 No No 2 2 1 2
R:R:G123 R:R:Q126 1.64 0 No Yes 4 7 2 1
R:R:Q102 R:R:S192 1.44 0 Yes No 5 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7XAU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.89
Number of Linked Nodes 270
Number of Links 304
Number of Hubs 40
Number of Links mediated by Hubs 149
Number of Communities 6
Number of Nodes involved in Communities 65
Number of Links involved in Communities 92
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 44342
Length Of Smallest Path 3
Average Path Length 13.6071
Length of Longest Path 34
Minimum Path Strength 1.32
Average Path Strength 6.97709
Maximum Path Strength 21.325
Minimum Path Correlation 0.7
Average Path Correlation 0.93081
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 51.8208
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.9806
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDPN
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeDPN
NameD-Phenylalanine
SynonymsD-Phenylalanine
Identifier
FormulaC9 H11 N O2
Molecular Weight165.189
SMILES
PubChem71567
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds23
Total Aromatic Bonds6

CodeDTR
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeDTR
NameD-Tryptophan
Synonyms
  • D-Tryptophan
  • (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
  • (R)-tryptophan
  • DTR
Identifier
FormulaC11 H12 N2 O2
Molecular Weight204.225
SMILES
PubChem6923517
Formal Charge0
Total Atoms27
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP30874
Sequence
>7XAU_nogp_Chain_R
TSNAVLTFI YFVVCIIGL CGNTLVIYV ILRYAKMKT ITNIYILNL 
AIADELFML GLPFLAMQV ALVHWPFGK AICRVVMTV DGINQFTSI 
FCLTVMSID RYLAVVHPI KSAKWRRPR TAKMITMAV WGVSLLVIL 
PIMIYAGLR SNQWGRSSC TINWPWYTG FIIYTFILG FLVPLTIIC 
LCYLFIIIK VKSSGIRVG SSKRKKSEK KVTRMVSIV VAVFIFCWL 
PFYIFNVSS VSMAISPTP ALKGMFDFV VVLTYANSC ANPILYAFL 
SDNFKKSFQ NV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XATAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAT (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAUAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ22.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAU (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAVAPeptideSomatostatinSST2Homo sapiensLanreotide-Gi1/β1/γ22.872022-08-31doi.org/10.1038/s41421-022-00405-2
7XAV (No Gprot) APeptideSomatostatinSST2Homo sapiensLanreotide-2.872022-08-31doi.org/10.1038/s41421-022-00405-2
7WICAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIC (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIGAPeptideSomatostatinSST2Homo sapiensL-054,264-Gi1/β1/γ22.72022-06-01doi.org/10.1038/s41422-022-00669-z
7WIG (No Gprot) APeptideSomatostatinSST2Homo sapiensL-054,264-2.72022-06-01doi.org/10.1038/s41422-022-00669-z
7XMRAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XMR (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XN9APeptideSomatostatinSST2Homo sapiensL-054,522--2.62022-08-03doi.org/10.1038/s41422-022-00679-x
7XNAAPeptideSomatostatinSST2Homo sapiensCYN154806--2.652022-08-03doi.org/10.1038/s41422-022-00679-x
7YACAPeptideSomatostatinSST2Homo sapiensPaltusotine-Gi1/β1/γ23.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAC (No Gprot) APeptideSomatostatinSST2Homo sapiensPaltusotine-3.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAEAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ23.372023-04-19doi.org/10.1038/s41467-023-36673-z
7YAE (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.372023-04-19doi.org/10.1038/s41467-023-36673-z
7Y24APeptideSomatostatinSST2Homo sapiensOctreotide-Go/β1/γ23.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y24 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26APeptideSomatostatinSST2Homo sapiensOctreotide-chim(NtGi2L-Gs-CtGq)/β1/γ23.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-3.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27APeptideSomatostatinSST2Homo sapiensSomatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ23.482022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.482022-10-19doi.org/10.1038/s41589-022-01130-3
7UL5APeptideSomatostatinSST2Homo sapiens---3.12022-06-29doi.org/10.1038/s41594-022-00859-8
7WJ5APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.722022-07-13doi.org/10.7554/eLife.76823
7WJ5 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-3.722022-07-13doi.org/10.7554/eLife.76823
7T10APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi3/β1/γ22.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T10 (No Gprot) APeptideSomatostatinSST2Homo sapiensSomatostatin-14-2.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T11APeptideSomatostatinSST2Homo sapiensOctreotide-Gi3/β1/γ22.72022-03-09doi.org/10.1038/s41594-022-00727-5
7T11 (No Gprot) APeptideSomatostatinSST2Homo sapiensOctreotide-2.72022-03-09doi.org/10.1038/s41594-022-00727-5




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