psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L46	R:R:N43	4.12	No	No	0	5	3
2	R:R:A44	R:R:F48	2.77	No	No	0	4	6
3	R:R:D295	R:R:L46	6.79	No	No	0	2	5
4	R:R:F48	R:R:T47	5.19	No	No	0	6	5
5	R:R:L96	R:R:Y50	9.38	No	Yes	0	7	7
6	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
7	R:R:V299	R:R:Y50	5.05	No	Yes	0	5	7
8	R:R:F51	R:R:I55	7.54	No	No	0	5	4
9	R:R:A303	R:R:V53	3.39	No	No	0	5	7
10	R:R:C54	R:R:L96	4.76	No	No	0	6	7
11	R:R:C306	R:R:I56	3.27	No	No	0	8	4
12	R:R:G57	R:R:M93	3.49	No	No	0	8	6
13	R:R:E90	R:R:L58	10.6	No	No	0	7	6
14	R:R:C59	R:R:G60	3.92	No	No	0	5	8
15	R:R:D89	R:R:N61	6.73	Yes	No	0	9	9
16	R:R:E90	R:R:N61	6.57	No	No	0	7	9
17	R:R:N61	R:R:P309	4.89	No	No	0	9	9
18	R:R:F314	R:R:V64	3.93	No	No	0	7	9
19	R:R:I65	R:R:L69	7.14	Yes	No	4	7	3
20	R:R:I65	R:R:L83	2.85	Yes	Yes	4	7	6
21	R:R:I65	R:R:I87	2.94	Yes	No	0	7	7
22	R:R:R70	R:R:Y66	8.23	No	No	0	4	3
23	R:R:V67	R:R:Y71	5.05	No	No	0	7	6
24	R:R:S322	R:R:V67	3.23	No	No	0	5	7
25	R:R:A72	R:R:I68	4.87	No	No	0	5	7
26	R:R:I68	R:R:L83	2.85	No	Yes	0	7	6
27	R:R:L69	R:R:L83	2.77	No	Yes	4	3	6
28	R:R:R70	R:R:Y71	7.2	No	No	0	4	6
29	R:R:K321	R:R:Y71	4.78	No	No	0	5	6
30	R:R:A72	R:R:N79	4.69	No	Yes	0	5	8
31	R:R:K73	R:R:K75	7.18	No	Yes	0	5	7
32	R:R:M74	R:R:P156	5.03	No	No	0	7	3
33	R:R:K160	R:R:M74	7.2	No	No	0	1	7
34	R:R:K75	R:R:T76	4.5	Yes	No	7	7	7
35	R:R:K75	R:R:N79	8.39	Yes	Yes	7	7	8
36	R:R:K321	R:R:K75	5.75	No	Yes	0	5	7
37	R:R:T76	R:R:T78	4.71	No	No	0	7	8
38	R:R:N79	R:R:T76	4.39	Yes	No	7	8	7
39	R:R:D139	R:R:I77	4.2	No	No	8	8	4
40	R:R:I77	R:R:R154	3.76	No	No	8	4	5
41	R:R:I82	R:R:T78	4.56	No	No	0	8	8
42	R:R:N318	R:R:N79	2.72	No	Yes	0	5	8
43	R:R:I80	R:R:N84	2.83	Yes	No	4	5	9
44	R:R:A159	R:R:I80	6.5	No	Yes	0	7	5
45	R:R:I80	R:R:K160	4.36	Yes	No	0	5	1
46	R:R:I80	R:R:T163	3.04	Yes	No	4	5	7
47	R:R:V135	R:R:Y81	5.05	No	Yes	0	7	7
48	R:R:M136	R:R:Y81	4.79	No	Yes	0	9	7
49	R:R:D139	R:R:Y81	6.9	No	Yes	0	8	7
50	R:R:A159	R:R:Y81	5.34	No	Yes	0	7	7
51	R:R:L83	R:R:N84	4.12	Yes	No	4	6	9
52	R:R:N84	R:R:T163	11.7	No	No	4	9	7
53	R:R:L133	R:R:L85	5.54	No	No	5	9	9
54	R:R:L85	R:R:N308	5.49	No	Yes	5	9	9
55	R:R:D89	R:R:S129	2.94	Yes	No	0	9	9
56	R:R:D89	R:R:S305	8.83	Yes	No	0	9	8
57	R:R:D89	R:R:N308	4.04	Yes	Yes	0	9	9
58	R:R:E90	R:R:M93	2.71	No	No	0	7	6
59	R:R:L91	R:R:N125	6.87	No	Yes	0	7	7
60	R:R:D122	R:R:F92	11.94	No	Yes	1	6	6
61	R:R:F92	R:R:N125	3.62	Yes	Yes	0	6	7
62	R:R:F92	R:R:Q126	9.37	Yes	Yes	1	6	7
63	R:R:F92	R:R:Y302	12.38	Yes	Yes	1	6	7
64	R:R:F92	R:R:S305	2.64	Yes	No	0	6	8
65	R:R:L96	R:R:P97	4.93	No	No	0	7	8
66	R:R:F98	R:R:P97	2.89	Yes	No	0	5	8
67	R:R:F98	R:R:W108	3.01	Yes	Yes	2	5	8
68	R:R:F110	R:R:F98	16.08	Yes	Yes	2	6	5
69	R:R:F98	R:R:V118	5.24	Yes	No	0	5	5
70	R:R:F110	R:R:M101	4.98	Yes	No	0	6	5
71	R:R:Q102	R:R:W108	6.57	Yes	Yes	2	5	8
72	R:R:Q102	R:R:S192	5.78	Yes	No	0	5	4
73	R:R:C193	R:R:Q102	6.1	No	Yes	2	9	5
74	L:L:T6	R:R:Q102	14.17	No	Yes	0	0	5
75	R:R:D295	R:R:V103	8.76	No	No	0	2	4
76	R:R:H107	R:R:L105	6.43	Yes	No	2	4	5
77	R:R:L105	R:R:P109	3.28	No	No	2	5	4
78	R:R:V106	R:R:W188	3.68	No	No	0	4	2
79	R:R:H107	R:R:P109	6.1	Yes	No	2	4	4
80	R:R:H107	R:R:R190	15.8	Yes	No	0	4	1
81	R:R:F110	R:R:W108	19.04	Yes	Yes	2	6	8
82	R:R:G111	R:R:W108	2.81	No	Yes	0	7	8
83	R:R:C115	R:R:W108	3.92	No	Yes	2	9	8
84	R:R:C193	R:R:W108	18.28	No	Yes	2	9	8
85	R:R:F110	R:R:P109	2.89	Yes	No	2	6	4
86	R:R:F110	R:R:I114	3.77	Yes	No	0	6	6
87	R:R:K112	R:R:R116	8.66	No	No	0	3	6
88	R:R:K112	R:R:L183	2.82	No	No	0	3	4
89	R:R:C115	R:R:C193	7.28	No	No	2	9	9
90	R:R:G182	R:R:R116	4.5	No	No	0	5	6
91	R:R:I177	R:R:M119	2.92	No	No	0	3	5
92	R:R:A181	R:R:M119	3.22	No	No	1	4	5
93	R:R:I195	R:R:M119	4.37	Yes	No	1	5	5
94	R:R:I124	R:R:T120	3.04	Yes	No	0	5	6
95	R:R:M178	R:R:T120	7.53	No	No	0	5	6
96	R:R:N125	R:R:V121	2.96	Yes	No	0	7	5
97	R:R:D122	R:R:Y302	11.49	No	Yes	1	6	7
98	L:L:K5	R:R:D122	4.15	Yes	No	1	0	6
99	R:R:I124	R:R:N125	2.83	Yes	Yes	0	5	7
100	R:R:I124	R:R:I174	5.89	Yes	Yes	0	5	7
101	R:R:Q126	R:R:W269	3.29	Yes	Yes	0	7	8
102	L:L:?4	R:R:Q126	7.4	Yes	Yes	1	0	7
103	L:L:K5	R:R:Q126	5.42	Yes	Yes	1	0	7
104	R:R:F127	R:R:V173	5.24	No	No	9	6	4
105	R:R:F127	R:R:I174	3.77	No	Yes	9	6	7
106	R:R:F127	R:R:L215	3.65	No	No	0	6	4
107	R:R:T128	R:R:W167	14.55	No	No	0	7	9
108	R:R:S170	R:R:T128	4.8	No	No	0	7	7
109	R:R:I130	R:R:P220	3.39	No	No	0	8	9
110	R:R:I130	R:R:W269	5.87	No	Yes	0	8	8
111	R:R:L133	R:R:N308	6.87	No	Yes	5	9	9
112	R:R:L133	R:R:Y312	11.72	No	Yes	5	9	9
113	R:R:I138	R:R:T134	3.04	No	No	3	6	7
114	R:R:P220	R:R:T134	3.5	No	No	0	9	7
115	R:R:I223	R:R:T134	3.04	No	No	3	6	7
116	R:R:I162	R:R:V135	3.07	No	No	0	5	7
117	R:R:M136	R:R:Y312	4.79	No	Yes	0	9	9
118	R:R:I224	R:R:S137	9.29	No	No	10	7	9
119	R:R:S137	R:R:Y228	5.09	No	Yes	10	9	9
120	R:R:I138	R:R:I223	2.94	No	No	3	6	6
121	R:R:D139	R:R:R154	15.48	No	No	8	8	5
122	R:R:R140	R:R:Y228	5.14	No	Yes	0	9	9
123	R:R:R140	R:R:Y312	4.12	No	Yes	0	9	9
124	R:R:V145	R:R:Y141	6.31	Yes	Yes	3	7	8
125	R:R:H146	R:R:Y141	4.36	No	Yes	3	5	8
126	R:R:C227	R:R:Y141	6.72	No	Yes	3	7	8
127	R:R:F230	R:R:Y141	6.19	No	Yes	0	4	8
128	R:R:I231	R:R:Y141	3.63	Yes	Yes	3	9	8
129	R:R:L142	R:R:S150	3	No	No	0	4	5
130	R:R:A143	R:R:R154	6.91	No	No	0	8	5
131	R:R:I231	R:R:V144	4.61	Yes	No	0	9	8
132	R:R:H146	R:R:V145	4.15	No	Yes	3	5	7
133	R:R:I231	R:R:V145	3.07	Yes	Yes	3	9	7
134	R:R:K234	R:R:V145	12.14	No	Yes	0	5	7
135	R:R:K152	R:R:W153	17.4	No	No	0	4	3
136	R:R:R155	R:R:W153	3	No	No	0	6	3
137	R:R:P156	R:R:R155	2.88	No	No	0	3	6
138	R:R:I162	R:R:T158	3.04	No	No	0	5	5
139	R:R:I162	R:R:M161	2.92	No	No	0	5	1
140	R:R:I174	R:R:V173	3.07	Yes	No	9	7	4
141	R:R:I174	R:R:I177	4.42	Yes	No	0	7	3
142	R:R:L175	R:R:P176	4.93	No	No	0	4	8
143	R:R:L175	R:R:M178	2.83	No	No	0	4	5
144	R:R:I179	R:R:L175	4.28	No	No	0	4	4
145	R:R:P176	R:R:Y180	2.78	No	Yes	0	8	4
146	R:R:F208	R:R:I177	6.28	Yes	No	0	7	3
147	R:R:I179	R:R:Y180	12.09	No	Yes	0	4	4
148	R:R:P198	R:R:Y180	9.74	Yes	Yes	1	5	4
149	R:R:E200	R:R:Y180	8.98	No	Yes	1	4	4
150	R:R:W204	R:R:Y180	8.68	Yes	Yes	1	3	4
151	R:R:A181	R:R:I195	4.87	No	Yes	1	4	5
152	R:R:N196	R:R:R184	7.23	No	No	0	3	2
153	R:R:R184	R:R:W197	7	No	No	0	2	5
154	R:R:N186	R:R:S192	7.45	No	No	0	1	4
155	R:R:I195	R:R:T194	3.04	Yes	No	0	5	4
156	L:L:?8	R:R:T194	7.65	Yes	No	0	0	4
157	L:L:F3	R:R:I195	3.77	Yes	Yes	1	0	5
158	R:R:P198	R:R:W197	2.7	Yes	No	0	5	5
159	R:R:W197	R:R:Y205	6.75	No	Yes	0	5	4
160	R:R:P198	R:R:W204	10.81	Yes	Yes	1	5	3
161	R:R:E200	R:R:S201	2.87	No	No	1	4	2
162	R:R:E200	R:R:W204	4.36	No	Yes	1	4	3
163	R:R:S201	R:R:W204	6.18	No	Yes	1	2	3
164	R:R:A203	R:R:Y205	4	No	Yes	0	1	4
165	R:R:F208	R:R:W204	11.02	Yes	Yes	1	7	3
166	L:L:F3	R:R:W204	3.01	Yes	Yes	1	0	3
167	R:R:V280	R:R:Y205	7.57	No	Yes	0	4	4
168	L:L:F3	R:R:Y205	7.22	Yes	Yes	0	0	4
169	R:R:T206	R:R:V280	4.76	No	No	0	3	4
170	R:R:F208	R:R:T212	7.78	Yes	No	0	7	4
171	L:L:F3	R:R:F208	5.36	Yes	Yes	1	0	7
172	R:R:I209	R:R:I210	2.94	Yes	No	0	5	5
173	R:R:I209	R:R:N276	8.5	Yes	No	0	5	6
174	R:R:I209	R:R:V280	6.14	Yes	No	0	5	4
175	R:R:T212	R:R:Y273	4.99	No	No	0	4	7
176	R:R:F213	R:R:I214	3.77	No	No	0	5	4
177	R:R:F213	R:R:F217	11.79	No	No	0	5	8
178	R:R:F213	R:R:Y273	11.35	No	No	0	5	7
179	R:R:I214	R:R:L218	2.85	No	No	0	4	4
180	R:R:G216	R:R:L215	3.42	No	No	0	6	4
181	R:R:F217	R:R:L221	3.65	No	Yes	0	8	6
182	R:R:F217	R:R:L270	6.09	No	No	0	8	5
183	R:R:P220	R:R:V219	3.53	No	No	0	9	5
184	R:R:C225	R:R:L221	3.17	No	Yes	0	5	6
185	R:R:F265	R:R:L221	3.65	No	Yes	0	9	6
186	R:R:I266	R:R:L221	4.28	No	Yes	0	6	6
187	R:R:L226	R:R:T222	2.95	No	No	0	5	4
188	R:R:I224	R:R:Y228	10.88	No	Yes	10	7	9
189	R:R:C225	R:R:V262	3.42	No	No	0	5	7
190	R:R:V258	R:R:Y228	12.62	No	Yes	0	8	9
191	R:R:V261	R:R:Y228	3.79	No	Yes	0	8	9
192	R:R:I232	R:R:V254	4.61	No	No	0	5	8
193	R:R:I232	R:R:T255	4.56	No	No	0	5	7
194	R:R:E251	R:R:V235	2.85	No	No	0	6	8
195	R:R:E251	R:R:K236	16.2	No	No	0	6	4
196	R:R:G239	R:R:S244	3.71	No	No	11	5	3
197	R:R:G239	R:R:R247	6	No	Yes	11	5	4
198	R:R:I240	R:R:K248	2.91	No	No	0	3	3
199	R:R:R247	R:R:S244	9.22	Yes	No	11	4	3
200	R:R:K248	R:R:S244	3.06	No	No	0	3	3
201	R:R:K246	R:R:K249	7.18	No	No	0	3	4
202	R:R:R247	R:R:S250	2.64	Yes	No	0	4	5
203	R:R:L311	R:R:V261	2.98	No	No	0	8	8
204	R:R:I266	R:R:V262	3.07	No	No	0	6	7
205	R:R:F265	R:R:W269	9.02	No	Yes	0	9	8
206	R:R:I266	R:R:L270	5.71	No	No	0	6	5
207	R:R:C268	R:R:N304	12.6	No	No	0	8	9
208	R:R:T301	R:R:W269	4.85	No	Yes	0	7	8
209	R:R:N304	R:R:W269	5.65	No	Yes	0	9	8
210	R:R:L300	R:R:P271	6.57	No	No	0	7	9
211	R:R:F272	R:R:Y273	5.16	No	No	0	6	7
212	L:L:?4	R:R:F272	6.77	Yes	No	0	0	6
213	R:R:F275	R:R:S278	3.96	No	No	0	4	4
214	R:R:F275	R:R:M293	4.98	No	No	0	4	4
215	L:L:?4	R:R:N276	7.63	Yes	No	0	0	6
216	R:R:I284	R:R:L290	4.28	No	No	0	1	4
217	R:R:P286	R:R:S285	5.34	No	No	0	2	2
218	L:L:?1	R:R:P286	5.57	Yes	No	0	0	2
219	R:R:P288	R:R:T287	3.5	No	No	0	3	1
220	R:R:L290	R:R:T287	5.9	No	No	0	4	1
221	R:R:F294	R:R:V298	6.55	Yes	No	0	4	6
222	L:L:?4	R:R:F294	3.87	Yes	Yes	0	0	4
223	L:L:C7	R:R:F294	2.79	Yes	Yes	0	0	4
224	L:L:K5	R:R:Y302	3.58	Yes	Yes	1	0	7
225	R:R:N308	R:R:P309	4.89	Yes	No	0	9	9
226	R:R:N308	R:R:Y312	5.81	Yes	Yes	5	9	9
227	R:R:L311	R:R:Y312	3.52	No	Yes	0	8	9
228	R:R:A313	R:R:F314	2.77	No	No	0	7	7
229	R:R:D317	R:R:S316	5.89	No	No	0	5	8
230	R:R:N318	R:R:S316	2.98	No	No	0	5	8
231	R:R:K321	R:R:N318	8.39	No	No	0	5	5
232	L:L:?1	L:L:C2	10.76	Yes	No	6	0	0
233	L:L:?1	L:L:C7	13.45	Yes	Yes	6	0	0
234	L:L:?1	L:L:?8	16.74	Yes	Yes	6	0	0
235	L:L:C2	L:L:C7	7.28	No	Yes	6	0	0
236	L:L:?4	L:L:F3	4.83	Yes	Yes	1	0	0
237	L:L:?4	L:L:K5	23.5	Yes	Yes	1	0	0
238	L:L:?8	L:L:C7	4.12	Yes	Yes	6	0	0
239	R:R:R190	R:R:V106	2.62	No	No	0	1	4
240	R:R:F131	R:R:V166	2.62	No	No	0	6	6
241	R:R:R247	R:R:V235	2.62	Yes	No	0	4	8
242	R:R:V103	R:R:Y50	2.52	No	Yes	0	4	7
243	R:R:F296	R:R:L300	2.44	No	No	0	5	7
244	R:R:T163	R:R:W167	2.43	No	No	0	7	9
245	L:L:?1	R:R:I284	2.42	Yes	No	0	0	1
246	R:R:F275	R:R:F294	2.14	No	Yes	0	4	4
247	R:R:G95	R:R:P97	2.03	No	No	0	6	8
248	R:R:G199	R:R:P198	2.03	No	Yes	0	3	5
249	R:R:C306	R:R:G57	1.96	No	No	0	8	8
250	R:R:A181	R:R:G182	1.95	No	No	0	4	5
251	L:L:?8	R:R:S192	1.95	Yes	No	0	0	4
252	R:R:G207	R:R:T206	1.82	No	No	0	4	3
253	R:R:P309	R:R:V64	1.77	No	No	0	9	9
254	R:R:P271	R:R:V297	1.77	No	No	0	9	7
255	R:R:G123	R:R:I174	1.76	No	Yes	0	4	7
256	L:L:C2	R:R:S279	1.72	No	No	0	0	4
257	R:R:A88	R:R:S129	1.71	No	No	0	8	9
258	R:R:G168	R:R:L171	1.71	No	No	0	4	3
259	R:R:C268	R:R:V264	1.71	No	No	0	8	7
260	R:R:A86	R:R:V64	1.7	No	No	0	9	9
261	R:R:A100	R:R:T47	1.68	No	No	0	6	5
262	R:R:A104	R:R:T47	1.68	No	No	0	5	5
263	R:R:K234	R:R:P147	1.67	No	No	0	5	8
264	R:R:C227	R:R:I138	1.64	No	No	3	7	6
265	R:R:C227	R:R:I223	1.64	No	No	3	7	6
266	R:R:L270	R:R:P271	1.64	No	No	0	5	9
267	L:L:C7	R:R:K291	1.62	Yes	No	0	0	3
268	R:R:V117	R:R:V121	1.6	No	No	0	5	5
269	R:R:V144	R:R:V235	1.6	No	No	0	8	8
270	R:R:S259	R:R:T255	1.6	No	No	0	4	7
271	R:R:C132	R:R:L85	1.59	No	No	0	8	9
272	R:R:A289	R:R:L290	1.58	No	No	0	1	4
273	R:R:I49	R:R:V45	1.54	No	No	0	5	5
274	R:R:I49	R:R:V53	1.54	No	No	0	5	7
275	R:R:I49	R:R:V299	1.54	No	No	0	5	5
276	R:R:I209	R:R:V277	1.54	Yes	No	0	5	5
277	R:R:I231	R:R:V254	1.54	Yes	No	0	9	8
278	R:R:I232	R:R:V258	1.54	No	No	0	5	8
279	R:R:I274	R:R:V277	1.54	No	No	0	5	5
280	R:R:K246	R:R:S250	1.53	No	No	0	3	5
281	R:R:I65	R:R:T62	1.52	Yes	No	0	7	5
282	R:R:N43	R:R:S42	1.49	No	No	0	3	4
283	R:R:I124	R:R:L171	1.43	Yes	No	0	5	3
284	R:R:I260	R:R:L311	1.43	No	No	0	6	8
285	R:R:L315	R:R:M257	1.41	No	No	0	6	8
286	R:R:H107	R:R:S191	1.39	Yes	No	0	4	5
287	R:R:R247	R:R:S238	1.32	Yes	No	0	4	5
288	R:R:F314	R:R:I310	1.26	No	No	0	7	6
289	R:R:T212	R:R:Y211	1.25	No	No	0	4	4
290	R:R:V166	R:R:W167	1.23	No	No	0	6	9
291	R:R:L99	R:R:Y50	1.17	No	Yes	0	6	7
292	R:R:L99	R:R:Y302	1.17	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y50	4.424	5	0	7
2	R:R:I65	3.6125	4	4	7
3	R:R:K75	6.455	4	7	7
4	R:R:N79	5.0475	4	7	8
5	R:R:I80	4.1825	4	4	5
6	R:R:Y81	5.52	4	0	7
7	R:R:L83	3.1475	4	4	6
8	R:R:D89	5.635	4	0	9
9	R:R:F92	7.99	5	1	6
10	R:R:F98	6.805	4	2	5
11	R:R:Q102	8.155	4	2	5
12	R:R:H107	7.43	4	2	4
13	R:R:W108	8.93833	6	2	8
14	R:R:F110	9.352	5	2	6
15	R:R:I124	3.2975	4	0	5
16	R:R:N125	4.07	4	0	7
17	R:R:Q126	6.37	4	1	7
18	R:R:Y141	5.442	5	3	8
19	R:R:V145	6.4175	4	3	7
20	R:R:I174	3.782	5	9	7
21	R:R:Y180	8.454	5	1	4
22	R:R:I195	4.0125	4	1	5
23	R:R:P198	6.32	4	1	5
24	R:R:W204	7.34333	6	1	3
25	R:R:Y205	6.385	4	0	4
26	R:R:F208	7.61	4	1	7
27	R:R:I209	4.78	4	0	5
28	R:R:L221	3.6875	4	0	6
29	R:R:Y228	7.504	5	10	9
30	R:R:I231	3.2125	4	3	9
31	R:R:R247	4.36	5	11	4
32	R:R:W269	5.736	5	0	8
33	R:R:F294	3.8375	4	0	4
34	R:R:Y302	7.155	4	1	7
35	R:R:N308	5.42	5	5	9
36	R:R:Y312	5.992	5	5	9
37	L:L:?1	9.788	5	6	0
38	L:L:F3	4.838	5	1	0
39	L:L:?4	9	6	1	0
40	L:L:K5	9.1625	4	1	0
41	L:L:C7	5.852	5	6	0
42	L:L:?8	7.615	4	6	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A100	R:R:T47	10.0701	1.68	No	No	0	6	5
2	R:R:A100	R:R:Y50	12.5547	4	No	Yes	0	6	7
3	R:R:V103	R:R:Y50	12.5477	2.52	No	Yes	0	4	7
4	R:R:D295	R:R:V103	10.0632	8.76	No	No	0	2	4
5	R:R:L96	R:R:Y50	33.8955	9.38	No	Yes	0	7	7
6	R:R:V299	R:R:Y50	12.5547	5.05	No	Yes	0	5	7
7	R:R:I49	R:R:V299	10.0701	1.54	No	No	0	5	5
8	R:R:E90	R:R:N61	14.7338	6.57	No	No	0	7	9
9	R:R:D89	R:R:N61	19.2172	6.73	Yes	No	0	9	9
10	R:R:D89	R:R:S305	99.5558	8.83	Yes	No	0	9	8
11	R:R:F92	R:R:S305	100	2.64	Yes	No	0	6	8
12	R:R:F92	R:R:Y302	45.0135	12.38	Yes	Yes	1	6	7
13	R:R:L99	R:R:Y302	69.0749	1.17	No	Yes	0	6	7
14	R:R:L99	R:R:Y50	67.319	1.17	No	Yes	0	6	7
15	R:R:N61	R:R:P309	11.4928	4.89	No	No	0	9	9
16	R:R:D89	R:R:N308	88.0908	4.04	Yes	Yes	0	9	9
17	R:R:N308	R:R:P309	15.0323	4.89	Yes	No	0	9	9
18	R:R:P309	R:R:V64	14.7755	1.77	No	No	0	9	9
19	R:R:L83	R:R:N84	48.3795	4.12	Yes	No	4	6	9
20	R:R:I80	R:R:N84	48.6987	2.83	Yes	No	4	5	9
21	R:R:A159	R:R:I80	68.3462	6.5	No	Yes	0	7	5
22	R:R:A159	R:R:Y81	69.6787	5.34	No	Yes	0	7	7
23	R:R:M136	R:R:Y81	81.0535	4.79	No	Yes	0	9	7
24	R:R:M136	R:R:Y312	82.1223	4.79	No	Yes	0	9	9
25	R:R:N308	R:R:Y312	86.3072	5.81	Yes	Yes	5	9	9
26	R:R:I68	R:R:L83	40.5372	2.85	No	Yes	0	7	6
27	R:R:A72	R:R:I68	38.9271	4.87	No	No	0	5	7
28	R:R:A72	R:R:N79	37.3031	4.69	No	Yes	0	5	8
29	R:R:K75	R:R:N79	14.3036	8.39	Yes	Yes	7	7	8
30	R:R:K321	R:R:K75	10.9445	5.75	No	Yes	0	5	7
31	R:R:K321	R:R:Y71	18.1414	4.78	No	No	0	5	6
32	R:R:N318	R:R:N79	16.1496	2.72	No	Yes	0	5	8
33	R:R:K321	R:R:N318	10.8613	8.39	No	No	0	5	5
34	R:R:I80	R:R:K160	11.1319	4.36	Yes	No	0	5	1
35	R:R:I80	R:R:T163	10.0701	3.04	Yes	No	4	5	7
36	R:R:F92	R:R:N125	26.7125	3.62	Yes	Yes	0	6	7
37	R:R:F92	R:R:Q126	87.3621	9.37	Yes	Yes	1	6	7
38	L:L:K5	R:R:Y302	27.1358	3.58	Yes	Yes	1	0	7
39	L:L:K5	R:R:Q126	17.5377	5.42	Yes	Yes	1	0	7
40	R:R:L96	R:R:P97	29.8147	4.93	No	No	0	7	8
41	R:R:F98	R:R:P97	26.0115	2.89	Yes	No	0	5	8
42	R:R:F110	R:R:F98	17.2739	16.08	Yes	Yes	2	6	5
43	R:R:Q102	R:R:W108	15.067	6.57	Yes	Yes	2	5	8
44	R:R:Q102	R:R:S192	20.6538	5.78	Yes	No	0	5	4
45	R:R:H107	R:R:P109	13.6998	6.1	Yes	No	2	4	4
46	R:R:F110	R:R:P109	19.1339	2.89	Yes	No	2	6	4
47	L:L:F3	R:R:I195	17.3988	3.77	Yes	Yes	1	0	5
48	L:L:?4	L:L:F3	41.8627	4.83	Yes	Yes	1	0	0
49	L:L:?4	L:L:K5	11.3054	23.5	Yes	Yes	1	0	0
50	R:R:I124	R:R:I174	11.7843	5.89	Yes	Yes	0	5	7
51	R:R:I124	R:R:N125	20.4109	2.83	Yes	Yes	0	5	7
52	R:R:Q126	R:R:W269	90.6864	3.29	Yes	Yes	0	7	8
53	R:R:I130	R:R:W269	69.4982	5.87	No	Yes	0	8	8
54	R:R:I130	R:R:P220	67.9298	3.39	No	No	0	8	9
55	R:R:I138	R:R:T134	31.7093	3.04	No	No	3	6	7
56	R:R:P220	R:R:T134	64.9039	3.5	No	No	0	9	7
57	R:R:I223	R:R:T134	31.7093	3.04	No	No	3	6	7
58	R:R:R140	R:R:Y228	25.5257	5.14	No	Yes	0	9	9
59	R:R:R140	R:R:Y312	26.8652	4.12	No	Yes	0	9	9
60	R:R:C227	R:R:I138	30.7516	1.64	No	No	3	7	6
61	R:R:C227	R:R:Y141	59.2616	6.72	No	Yes	3	7	8
62	R:R:C227	R:R:I223	30.7516	1.64	No	No	3	7	6
63	R:R:I231	R:R:Y141	45.0413	3.63	Yes	Yes	3	9	8
64	R:R:I231	R:R:V144	45.1523	4.61	Yes	No	0	9	8
65	L:L:F3	R:R:W204	16.337	3.01	Yes	Yes	1	0	3
66	L:L:F3	R:R:Y205	16.2399	7.22	Yes	Yes	0	0	4
67	R:R:I195	R:R:T194	10.8404	3.04	Yes	No	0	5	4
68	L:L:?8	L:L:C7	17.2253	4.12	Yes	Yes	6	0	0
69	L:L:C7	R:R:F294	35.7207	2.79	Yes	Yes	0	0	4
70	L:L:?4	R:R:F294	42.8552	3.87	Yes	Yes	0	0	4
71	L:L:?8	R:R:S192	23.3326	1.95	Yes	No	0	0	4
72	L:L:?4	R:R:N276	13.8941	7.63	Yes	No	0	0	6
73	R:R:I209	R:R:N276	12.0411	8.5	Yes	No	0	5	6
74	L:L:?4	R:R:F272	13.7969	6.77	Yes	No	0	0	6
75	R:R:F272	R:R:Y273	12.2493	5.16	No	No	0	6	7
76	R:R:F213	R:R:Y273	12.166	11.35	No	No	0	5	7
77	R:R:F217	R:R:L221	11.1805	3.65	No	Yes	0	8	6
78	R:R:F265	R:R:L221	28.4267	3.65	No	Yes	0	9	6
79	R:R:F265	R:R:W269	30.4601	9.02	No	Yes	0	9	8
80	R:R:F217	R:R:L270	12.9641	6.09	No	No	0	8	5
81	R:R:I266	R:R:L221	12.1938	4.28	No	Yes	0	6	6
82	R:R:V258	R:R:Y228	22.0418	12.62	No	Yes	0	8	9
83	R:R:I232	R:R:V258	20.5635	1.54	No	No	0	5	8
84	R:R:I232	R:R:V254	17.6418	4.61	No	No	0	5	8
85	R:R:V144	R:R:V235	41.7447	1.6	No	No	0	8	8
86	R:R:R247	R:R:V235	31.5705	2.62	Yes	No	0	4	8
87	R:R:R247	R:R:S244	10.6947	9.22	Yes	No	11	4	3
88	R:R:R247	R:R:S250	10.7155	2.64	Yes	No	0	4	5
89	R:R:L270	R:R:P271	16.1496	1.64	No	No	0	5	9
90	L:L:?1	R:R:I284	10.8196	2.42	Yes	No	0	0	1
91	L:L:?1	L:L:C7	13.1515	13.45	Yes	Yes	6	0	0
92	L:L:?4	R:R:Q126	78.8396	7.4	Yes	Yes	1	0	7
93	R:R:I231	R:R:V254	18.0373	1.54	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D122	R:R:F92	11.94	1	No	Yes	6	6	1	2
R:R:F92	R:R:Q126	9.37	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	12.38	1	Yes	Yes	6	7	2	1
R:R:Q102	R:R:W108	6.57	2	Yes	Yes	5	8	1	2
R:R:Q102	R:R:S192	5.78	2	Yes	No	5	4	1	1
R:R:C193	R:R:Q102	6.1	2	No	Yes	9	5	2	1
L:L:T6	R:R:Q102	14.17	0	No	Yes	0	5	0	1
R:R:C193	R:R:W108	18.28	2	No	Yes	9	8	2	2
R:R:I177	R:R:M119	2.92	0	No	No	3	5	2	2
R:R:A181	R:R:M119	3.22	1	No	No	4	5	2	2
R:R:I195	R:R:M119	4.37	1	Yes	No	5	5	1	2
R:R:D122	R:R:Y302	11.49	1	No	Yes	6	7	1	1
L:L:K5	R:R:D122	4.15	1	Yes	No	0	6	0	1
R:R:Q126	R:R:W269	3.29	1	Yes	Yes	7	8	1	2
L:L:?4	R:R:Q126	7.4	1	Yes	Yes	0	7	0	1
L:L:K5	R:R:Q126	5.42	1	Yes	Yes	0	7	0	1
R:R:F208	R:R:I177	6.28	1	Yes	No	7	3	1	2
R:R:P198	R:R:Y180	9.74	1	Yes	Yes	5	4	2	2
R:R:E200	R:R:Y180	8.98	1	No	Yes	4	4	2	2
R:R:W204	R:R:Y180	8.68	1	Yes	Yes	3	4	1	2
R:R:A181	R:R:I195	4.87	1	No	Yes	4	5	2	1
R:R:N186	R:R:S192	7.45	0	No	No	1	4	2	1
R:R:I195	R:R:T194	3.04	1	Yes	No	5	4	1	1
L:L:?8	R:R:T194	7.65	6	Yes	No	0	4	0	1
L:L:F3	R:R:I195	3.77	1	Yes	Yes	0	5	0	1
R:R:P198	R:R:W197	2.7	1	Yes	No	5	5	2	2
R:R:W197	R:R:Y205	6.75	0	No	Yes	5	4	2	1
R:R:P198	R:R:W204	10.81	1	Yes	Yes	5	3	2	1
R:R:E200	R:R:S201	2.87	1	No	No	4	2	2	2
R:R:E200	R:R:W204	4.36	1	No	Yes	4	3	2	1
R:R:S201	R:R:W204	6.18	1	No	Yes	2	3	2	1
R:R:A203	R:R:Y205	4	0	No	Yes	1	4	2	1
R:R:F208	R:R:W204	11.02	1	Yes	Yes	7	3	1	1
L:L:F3	R:R:W204	3.01	1	Yes	Yes	0	3	0	1
R:R:V280	R:R:Y205	7.57	0	No	Yes	4	4	2	1
L:L:F3	R:R:Y205	7.22	1	Yes	Yes	0	4	0	1
R:R:F208	R:R:T212	7.78	1	Yes	No	7	4	1	2
L:L:F3	R:R:F208	5.36	1	Yes	Yes	0	7	0	1
R:R:I209	R:R:N276	8.5	0	Yes	No	5	6	2	1
R:R:I209	R:R:V280	6.14	0	Yes	No	5	4	2	2
R:R:T212	R:R:Y273	4.99	0	No	No	4	7	2	2
R:R:F272	R:R:Y273	5.16	0	No	No	6	7	1	2
L:L:?4	R:R:F272	6.77	1	Yes	No	0	6	0	1
L:L:?4	R:R:N276	7.63	1	Yes	No	0	6	0	1
R:R:I284	R:R:L290	4.28	0	No	No	1	4	1	2
R:R:P286	R:R:S285	5.34	0	No	No	2	2	1	2
L:L:?1	R:R:P286	5.57	6	Yes	No	0	2	0	1
R:R:F294	R:R:V298	6.55	0	Yes	No	4	6	1	2
L:L:?4	R:R:F294	3.87	1	Yes	Yes	0	4	0	1
L:L:C7	R:R:F294	2.79	6	Yes	Yes	0	4	0	1
L:L:K5	R:R:Y302	3.58	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I284	2.42	6	Yes	No	0	1	0	1
R:R:F275	R:R:F294	2.14	0	No	Yes	4	4	2	1
L:L:?8	R:R:S192	1.95	6	Yes	No	0	4	0	1
L:L:C2	R:R:S279	1.72	6	No	No	0	4	0	1
L:L:C7	R:R:K291	1.62	6	Yes	No	0	3	0	1
R:R:L99	R:R:Y302	1.17	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YAE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	254
Number of Links	292
Number of Hubs	42
Number of Links mediated by Hubs	153
Number of Communities	11
Number of Nodes involved in Communities	62
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	43016
Length Of Smallest Path	3
Average Path Length	13.4088
Length of Longest Path	31
Minimum Path Strength	1.17
Average Path Strength	5.13698
Maximum Path Strength	18.66
Minimum Path Correlation	0.7
Average Path Correlation	0.927292
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.5538
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.3647
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • neuropeptide binding • peptide binding • PDZ domain binding • protein domain specific binding • neuropeptide signaling pathway • negative regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to estradiol • cellular response to estradiol stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • response to corticosteroid • response to steroid hormone • cellular response to steroid hormone stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	THO
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	THO
Name	L-Threoninol
Synonyms	L-Threoninol
Identifier
Formula	C4 H11 N O2
Molecular Weight	105.136
SMILES
PubChem	2033049
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	2
Total Bonds	17
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7YAE_nogp_Chain_R S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P G E S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

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