CodeDPN
NameD-Phenylalanine
SynonymsD-Phenylalanine
Identifier(2R)-2-azanyl-3-phenyl-propanoic acid
FormulaC9 H11 N O2
Molecular Weight165.189
SMILESc1ccc(cc1)C[C@H](C(=O)O)N
PubChem6919011
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds23
Total Aromatic Bonds6
Networks15
 missing image

This ligand is also present in the following 15 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7AUE A Peptide Melanocortin MC4 Homo sapiens Setmelanotide - chim(NtGi1L-Gs)/Beta1/Gamma2 2.97 2021-04-28 10.1126/science.abf7958

A 2D representation of the interactions of DPN in 7AUE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I129 R:R:N97 4.25 11 Yes No 5 6 1 2
R:R:E100 R:R:I125 6.83 11 Yes No 5 5 1 2
R:R:D126 R:R:E100 9.09 11 Yes Yes 4 5 1 1
R:R:E100 R:R:I129 2.73 11 Yes Yes 5 5 1 1
L:L:?6 R:R:E100 5.64 11 Yes Yes 0 5 0 1
R:R:D122 R:R:D126 9.31 0 No Yes 8 4 2 1
L:L:?6 R:R:D126 10.4 11 Yes Yes 0 4 0 1
L:L:R7 R:R:D126 5.96 11 Yes Yes 0 4 1 1
R:R:I129 R:R:L133 2.85 11 Yes Yes 5 5 1 2
L:L:?6 R:R:I129 15.79 11 Yes Yes 0 5 0 1
L:L:R7 R:R:I185 6.26 11 Yes No 0 5 1 2
L:L:R7 R:R:S188 9.22 11 Yes No 0 4 1 2
L:L:W8 R:R:S188 8.65 0 No No 0 4 1 2
L:L:W8 R:R:I194 5.87 0 No No 0 4 1 2
R:R:F284 R:R:L288 4.87 18 Yes No 3 4 2 1
L:L:?6 R:R:L288 3.53 11 Yes No 0 4 0 1
L:L:?6 L:L:R7 7.24 11 Yes Yes 0 0 0 1
L:L:?6 L:L:W8 2.91 11 Yes No 0 0 0 1
L:L:R7 R:R:N123 2.41 11 Yes No 0 5 1 2
R:R:I129 R:R:S96 1.55 11 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.59
Average Nodes In Shell17.00
Average Hubs In Shell7.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F4F A Peptide Melanocortin MC1 Homo sapiens Afamelanotide - chim(NtGi1-Gs)/Beta1/Gamma2 2.9 2021-09-08 10.1038/s41422-021-00557-y

A 2D representation of the interactions of DPN in 7F4F
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S90 R:R:T124 4.8 0 No No 5 5 2 1
R:R:D117 R:R:E94 3.9 2 Yes Yes 6 4 2 1
R:R:E94 R:R:I120 5.47 2 Yes No 4 5 1 2
R:R:D121 R:R:E94 6.5 2 Yes Yes 5 4 1 1
L:L:?7 R:R:E94 7.9 2 Yes Yes 0 4 0 1
R:R:D117 R:R:D121 10.65 2 Yes Yes 6 5 2 1
L:L:R8 R:R:D117 7.15 2 Yes Yes 0 6 1 2
R:R:I180 R:R:N118 4.25 2 Yes Yes 5 4 2 2
L:L:R8 R:R:N118 8.44 2 Yes Yes 0 4 1 2
R:R:D121 R:R:I180 4.2 2 Yes Yes 5 5 1 2
L:L:?7 R:R:D121 15.02 2 Yes Yes 0 5 0 1
L:L:R8 R:R:D121 14.29 2 Yes Yes 0 5 1 1
L:L:?7 R:R:T124 11.29 2 Yes No 0 5 0 1
L:L:?7 R:R:C125 6.75 2 Yes No 0 4 0 1
R:R:M128 R:R:W254 5.82 2 Yes Yes 5 7 1 2
R:R:I287 R:R:M128 4.37 2 No Yes 7 5 2 1
L:L:?7 R:R:M128 8.42 2 Yes Yes 0 5 0 1
L:L:R8 R:R:I180 8.77 2 Yes Yes 0 5 1 2
L:L:R8 R:R:Y183 11.32 2 Yes No 0 3 1 2
L:L:W9 R:R:Y183 5.79 2 Yes No 0 3 1 2
L:L:W9 R:R:V188 3.68 2 Yes No 0 4 1 2
R:R:L189 R:R:L261 5.54 2 No Yes 4 5 2 2
L:L:W9 R:R:L189 13.67 2 Yes No 0 4 1 2
R:R:L192 R:R:L261 4.15 2 No Yes 5 5 2 2
L:L:W9 R:R:L192 4.56 2 Yes No 0 5 1 2
R:R:I287 R:R:W254 11.74 2 No Yes 7 7 2 2
R:R:F257 R:R:F258 9.65 0 Yes No 5 5 1 2
R:R:F257 R:R:L261 8.53 0 Yes Yes 5 5 1 2
R:R:F257 R:R:F280 4.29 0 Yes Yes 5 4 1 2
R:R:F257 R:R:I287 5.02 0 Yes No 5 7 1 2
L:L:?7 R:R:F257 6.22 2 Yes Yes 0 5 0 1
L:L:W9 R:R:L261 4.56 2 Yes Yes 0 5 1 2
R:R:F280 R:R:L284 10.96 0 Yes No 4 4 2 1
L:L:?7 R:R:L284 4.71 2 Yes No 0 4 0 1
L:L:?7 L:L:R8 12.41 2 Yes Yes 0 0 0 1
L:L:?7 L:L:W9 6.79 2 Yes Yes 0 0 0 1
L:L:R8 L:L:W9 6 2 Yes Yes 0 0 1 1
R:R:C125 R:R:S176 3.44 0 No No 4 7 1 2
R:R:M128 R:R:V87 3.04 2 Yes No 5 8 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.83
Average Nodes In Shell26.00
Average Hubs In Shell13.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F4H A Peptide Melanocortin MC1 Homo sapiens Afamelanotide - chim(NtGi1-Gs)/Beta1/Gamma2 2.7 2021-09-08 10.1038/s41422-021-00557-y

A 2D representation of the interactions of DPN in 7F4H
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S90 R:R:T124 6.4 0 No Yes 5 5 2 1
R:R:N91 R:R:T124 8.77 2 Yes Yes 7 5 2 1
R:R:D121 R:R:E94 6.5 2 Yes No 5 4 1 1
L:L:H6 R:R:E94 7.39 2 Yes No 0 4 2 1
L:L:?7 R:R:E94 12.41 2 Yes No 0 4 0 1
R:R:D117 R:R:D121 9.31 2 No Yes 6 5 2 1
L:L:R8 R:R:D117 5.96 2 Yes No 0 6 1 2
R:R:I180 R:R:N118 4.25 2 Yes No 5 4 1 2
L:L:?7 R:R:D121 18.48 2 Yes Yes 0 5 0 1
L:L:R8 R:R:D121 14.29 2 Yes Yes 0 5 1 1
R:R:I180 R:R:V122 4.61 2 Yes No 5 5 1 2
R:R:M128 R:R:T124 4.52 2 Yes Yes 5 5 1 1
L:L:?7 R:R:T124 11.29 2 Yes Yes 0 5 0 1
R:R:C125 R:R:S176 6.89 2 No No 4 7 1 2
R:R:C125 R:R:I180 6.55 2 No Yes 4 5 1 1
L:L:?7 R:R:C125 4.05 2 Yes No 0 4 0 1
R:R:M128 R:R:W254 5.82 2 Yes Yes 5 7 1 2
R:R:I287 R:R:M128 4.37 2 Yes Yes 7 5 2 1
L:L:?7 R:R:M128 4.81 2 Yes Yes 0 5 0 1
L:L:?7 R:R:I180 4.86 2 Yes Yes 0 5 0 1
L:L:R8 R:R:I180 5.01 2 Yes Yes 0 5 1 1
L:L:R8 R:R:Y183 23.66 2 Yes No 0 3 1 2
L:L:W9 R:R:Y183 5.79 2 Yes No 0 3 1 2
R:R:L189 R:R:L261 4.15 2 Yes No 4 5 2 2
L:L:W9 R:R:L189 10.25 2 Yes Yes 0 4 1 2
R:R:F258 R:R:W254 6.01 2 Yes Yes 5 7 2 2
R:R:I287 R:R:W254 8.22 2 Yes Yes 7 7 2 2
R:R:F257 R:R:F258 10.72 0 Yes Yes 5 5 1 2
R:R:F257 R:R:L261 13.4 0 Yes No 5 5 1 2
R:R:F257 R:R:F280 6.43 0 Yes Yes 5 4 1 2
R:R:F257 R:R:I287 6.28 0 Yes Yes 5 7 1 2
L:L:?7 R:R:F257 6.22 2 Yes Yes 0 5 0 1
L:L:W9 R:R:L261 6.83 2 Yes No 0 5 1 2
L:L:?7 L:L:R8 11.38 2 Yes Yes 0 0 0 1
L:L:?7 L:L:W9 6.79 2 Yes Yes 0 0 0 1
L:L:R8 L:L:W9 7 2 Yes Yes 0 0 1 1
R:R:D121 R:R:I120 2.8 2 Yes No 5 5 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.92
Average Nodes In Shell25.00
Average Hubs In Shell15.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F54 A Peptide Melanocortin MC4 Homo sapiens Afamelanotide - Gs/Beta1/Gamma2 3 2021-11-03 10.1038/s41422-021-00552-3

A 2D representation of the interactions of DPN in 7F54
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F284 R:R:Q43 3.51 5 Yes No 3 3 1 2
R:R:I129 R:R:S96 6.19 0 No No 5 6 1 2
R:R:I129 R:R:N97 14.16 0 No No 5 6 1 2
R:R:D122 R:R:E100 3.9 5 No Yes 8 5 2 1
R:R:E100 R:R:I125 9.56 5 Yes No 5 5 1 2
R:R:D126 R:R:E100 7.8 5 Yes Yes 4 5 1 1
L:L:?4 R:R:E100 7.52 5 Yes Yes 0 5 2 1
L:L:?7 R:R:E100 5.64 5 Yes Yes 0 5 0 1
R:R:D122 R:R:D126 6.65 5 No Yes 8 4 2 1
L:L:?4 R:R:D122 23.09 5 Yes No 0 8 2 2
R:R:D126 R:R:I185 4.2 5 Yes Yes 4 5 1 2
L:L:?7 R:R:D126 11.55 5 Yes Yes 0 4 0 1
L:L:R8 R:R:D126 10.72 5 Yes Yes 0 4 1 1
L:L:?7 R:R:I129 12.15 5 Yes No 0 5 0 1
L:L:R8 R:R:I185 8.77 5 Yes Yes 0 5 1 2
L:L:R8 R:R:S188 11.86 5 Yes No 0 4 1 2
R:R:I194 R:R:L265 7.14 5 No No 4 5 2 2
L:L:W9 R:R:I194 11.74 5 Yes No 0 4 1 2
L:L:W9 R:R:L197 3.42 5 Yes No 0 5 1 2
R:R:F261 R:R:F262 5.36 5 Yes No 5 5 1 2
R:R:F261 R:R:L265 4.87 5 Yes No 5 5 1 2
R:R:F261 R:R:F284 6.43 5 Yes Yes 5 3 1 1
R:R:F261 R:R:I291 6.28 5 Yes No 5 6 1 2
L:L:?7 R:R:F261 5.18 5 Yes Yes 0 5 0 1
R:R:F284 R:R:H264 10.18 5 Yes No 3 4 1 2
L:L:W9 R:R:L265 4.56 5 Yes No 0 5 1 2
L:L:W9 R:R:Y268 16.4 5 Yes No 0 5 1 2
R:R:F284 R:R:L288 13.4 5 Yes No 3 4 1 2
L:L:?7 R:R:F284 6.22 5 Yes Yes 0 3 0 1
L:L:G10 R:R:F284 6.02 0 No Yes 0 3 2 1
L:L:?7 L:L:R8 11.38 5 Yes Yes 0 0 0 1
L:L:?7 L:L:W9 3.88 5 Yes Yes 0 0 0 1
L:L:R8 L:L:W9 9 5 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.00
Average Nodes In Shell25.00
Average Hubs In Shell9.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F55 A Peptide Melanocortin MC4 Homo sapiens Bremelanotide - Gs/Beta1/Gamma2 3.1 2021-11-03 10.1038/s41422-021-00552-3

A 2D representation of the interactions of DPN in 7F55
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F284 R:R:Q43 3.51 4 Yes No 3 3 1 2
R:R:I129 R:R:S96 4.64 0 No No 5 6 1 2
R:R:I129 R:R:N97 9.91 0 No No 5 6 1 2
R:R:D122 R:R:E100 3.9 4 No Yes 8 5 2 1
R:R:E100 R:R:I125 9.56 4 Yes No 5 5 1 2
R:R:D126 R:R:E100 7.8 4 Yes Yes 4 5 1 1
L:L:?1 R:R:E100 7.52 4 Yes Yes 0 5 2 1
L:L:?4 R:R:E100 5.64 4 Yes Yes 0 5 0 1
R:R:D122 R:R:D126 7.98 4 No Yes 8 4 2 1
L:L:?1 R:R:D122 23.09 4 Yes No 0 8 2 2
R:R:D126 R:R:I185 4.2 4 Yes Yes 4 5 1 2
L:L:?4 R:R:D126 15.02 4 Yes Yes 0 4 0 1
L:L:R5 R:R:D126 8.34 4 Yes Yes 0 4 1 1
L:L:?4 R:R:I129 12.15 4 Yes No 0 5 0 1
L:L:R5 R:R:I185 3.76 4 Yes Yes 0 5 1 2
L:L:R5 R:R:S188 10.54 4 Yes No 0 4 1 2
L:L:W6 R:R:S188 6.18 4 Yes No 0 4 1 2
R:R:I194 R:R:L265 7.14 4 No No 4 5 2 2
L:L:W6 R:R:I194 8.22 4 Yes No 0 4 1 2
R:R:F261 R:R:F262 5.36 4 Yes No 5 5 1 2
R:R:F261 R:R:L265 4.87 4 Yes No 5 5 1 2
R:R:F261 R:R:F284 6.43 4 Yes Yes 5 3 1 1
R:R:F261 R:R:I291 6.28 4 Yes No 5 6 1 2
L:L:?4 R:R:F261 5.18 4 Yes Yes 0 5 0 1
R:R:F284 R:R:H264 10.18 4 Yes No 3 4 1 2
L:L:W6 R:R:L265 3.42 4 Yes No 0 5 1 2
L:L:W6 R:R:Y268 13.5 4 Yes No 0 5 1 2
R:R:F284 R:R:L288 13.4 4 Yes No 3 4 1 2
L:L:?4 R:R:F284 5.18 4 Yes Yes 0 3 0 1
L:L:K7 R:R:F284 11.17 0 No Yes 0 3 2 1
L:L:?4 L:L:R5 5.17 4 Yes Yes 0 0 0 1
L:L:?4 L:L:W6 5.82 4 Yes Yes 0 0 0 1
L:L:R5 L:L:W6 4 4 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.74
Average Nodes In Shell24.00
Average Hubs In Shell9.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F9Z A Peptide Ghrelin Ghrelin Homo sapiens GHRP-6 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.2 2021-08-18 10.1038/s41467-021-25364-2

A 2D representation of the interactions of DPN in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:?3 30.44 3 Yes Yes 0 0 2 2
L:L:?2 L:L:?6 9.62 3 Yes Yes 0 0 2 1
L:L:?2 R:R:D99 5.43 3 Yes No 0 6 2 2
L:L:?2 R:R:F309 9.75 3 Yes Yes 0 5 2 2
L:L:?3 L:L:?4 18.04 3 Yes Yes 0 0 2 1
L:L:?3 R:R:F286 9.91 3 Yes Yes 0 4 2 2
L:L:?4 L:L:?5 14.15 3 Yes Yes 0 0 1 0
L:L:?4 L:L:?6 9.62 3 Yes Yes 0 0 1 1
L:L:?4 R:R:F286 3.9 3 Yes Yes 0 4 1 2
L:L:?4 R:R:S308 4.81 3 Yes No 0 7 1 2
L:L:?4 R:R:F309 8.78 3 Yes Yes 0 5 1 2
L:L:?5 L:L:?6 28.63 3 Yes Yes 0 0 0 1
L:L:?5 L:L:?7 5.87 3 Yes Yes 0 0 0 1
L:L:?5 R:R:E124 5.64 3 Yes Yes 0 4 0 1
L:L:?5 R:R:L181 11.78 3 Yes No 0 4 0 1
L:L:?5 R:R:P200 6.99 3 Yes No 0 4 0 1
L:L:?5 R:R:M213 12.03 3 Yes No 0 5 0 1
L:L:?5 R:R:R283 27.92 3 Yes Yes 0 6 0 1
L:L:?6 L:L:?7 23.95 3 Yes Yes 0 0 1 1
L:L:?6 R:R:D99 4.71 3 Yes No 0 6 1 2
L:L:?6 R:R:Q120 21.95 3 Yes Yes 0 4 1 2
L:L:?6 R:R:E124 6.9 3 Yes Yes 0 4 1 1
L:L:?6 R:R:I178 4.95 3 Yes No 0 4 1 2
L:L:?7 R:R:Q120 9.95 3 Yes Yes 0 4 1 2
L:L:?7 R:R:E124 13.21 3 Yes Yes 0 4 1 1
R:R:D99 R:R:F309 9.55 3 No Yes 6 5 2 2
R:R:E124 R:R:Y128 4.49 3 Yes No 4 6 1 2
R:R:E124 R:R:I178 6.83 3 Yes No 4 4 1 2
R:R:E124 R:R:R283 5.82 3 Yes Yes 4 6 1 1
R:R:S217 R:R:Y128 5.09 0 No No 6 6 2 2
R:R:L181 R:R:M213 7.07 3 No No 4 5 1 1
R:R:R283 R:R:S217 7.91 3 Yes No 6 6 1 2
R:R:F279 R:R:R283 8.55 0 No Yes 6 6 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength14.13
Average Nodes In Shell20.00
Average Hubs In Shell11.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7PIU A Peptide Melanocortin MC4 Homo sapiens Setmelanotide - Gs/Beta1/Gamma2 2.58 2021-11-17 10.1038/s41422-021-00569-8

A 2D representation of the interactions of DPN in 7PIU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F284 R:R:Q43 3.51 2 Yes No 3 3 1 2
R:R:N285 R:R:Q43 7.92 2 No No 4 3 2 2
R:R:F51 R:R:T101 9.08 2 Yes No 6 6 2 2
R:R:F51 R:R:N285 3.62 2 Yes No 6 4 2 2
L:L:H4 R:R:F51 22.63 2 Yes Yes 0 6 1 2
R:R:I129 R:R:S96 4.64 0 Yes No 5 6 1 2
R:R:I129 R:R:N97 11.33 0 Yes No 5 6 1 2
R:R:E100 R:R:I125 4.1 0 No No 5 5 1 2
L:L:?5 R:R:E100 4.51 2 Yes No 0 5 0 1
L:L:H4 R:R:T101 6.85 2 Yes No 0 6 1 2
R:R:D122 R:R:D126 3.99 2 No Yes 8 4 2 1
L:L:R6 R:R:D122 3.57 2 Yes No 0 8 1 2
L:L:R6 R:R:N123 4.82 2 Yes No 0 5 1 2
R:R:D126 R:R:I185 4.2 2 Yes Yes 4 5 1 2
L:L:?5 R:R:D126 10.4 2 Yes Yes 0 4 0 1
L:L:R6 R:R:D126 16.68 2 Yes Yes 0 4 1 1
R:R:I129 R:R:S132 3.1 0 Yes No 5 6 1 2
L:L:?5 R:R:I129 14.58 2 Yes Yes 0 5 0 1
L:L:R6 R:R:I185 6.26 2 Yes Yes 0 5 1 2
L:L:R6 R:R:S188 7.91 2 Yes No 0 4 1 2
L:L:W7 R:R:S188 3.71 2 Yes No 0 4 2 2
R:R:F261 R:R:F262 7.5 2 Yes Yes 5 5 1 2
R:R:F261 R:R:L265 6.09 2 Yes Yes 5 5 1 2
R:R:F261 R:R:F284 4.29 2 Yes Yes 5 3 1 1
R:R:F261 R:R:I291 3.77 2 Yes No 5 6 1 2
L:L:?5 R:R:F261 6.22 2 Yes Yes 0 5 0 1
R:R:F262 R:R:L265 3.65 2 Yes Yes 5 5 2 2
R:R:F284 R:R:H264 15.84 2 Yes No 3 4 1 2
L:L:W7 R:R:L265 3.42 2 Yes Yes 0 5 2 2
R:R:F284 R:R:L288 9.74 2 Yes No 3 4 1 1
L:L:?5 R:R:F284 4.15 2 Yes Yes 0 3 0 1
L:L:C8 R:R:F284 8.38 0 No Yes 0 3 2 1
L:L:H4 R:R:N285 5.1 2 Yes No 0 4 1 2
L:L:?5 R:R:L288 3.53 2 Yes No 0 4 0 1
L:L:?3 L:L:H4 14.39 0 No Yes 0 0 2 1
L:L:?5 L:L:H4 3.28 2 Yes Yes 0 0 0 1
L:L:?5 L:L:R6 6.2 2 Yes Yes 0 0 0 1
L:L:R6 L:L:W7 13.99 2 Yes Yes 0 0 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.61
Average Nodes In Shell28.00
Average Hubs In Shell12.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7PIV A Peptide Melanocortin MC4 Homo sapiens Setmelanotide - Gs/Beta1/Gamma2 2.86 2021-11-17 10.1038/s41422-021-00569-8

A 2D representation of the interactions of DPN in 7PIV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I129 R:R:S96 6.19 0 No No 5 6 1 2
R:R:D122 R:R:E100 3.9 2 No Yes 8 5 2 1
R:R:E100 R:R:I125 8.2 2 Yes No 5 5 1 2
R:R:D126 R:R:E100 5.2 2 Yes Yes 4 5 1 1
L:L:?4 R:R:E100 5.01 2 Yes Yes 0 5 2 1
L:L:?7 R:R:E100 3.38 2 Yes Yes 0 5 0 1
R:R:D122 R:R:D126 6.65 2 No Yes 8 4 2 1
L:L:?4 R:R:D122 16.68 2 Yes No 0 8 2 2
R:R:D126 R:R:I185 4.2 2 Yes Yes 4 5 1 2
L:L:?7 R:R:D126 4.62 2 Yes Yes 0 4 0 1
L:L:R8 R:R:D126 14.29 2 Yes Yes 0 4 1 1
L:L:?7 R:R:I129 13.36 2 Yes No 0 5 0 1
L:L:R8 R:R:I185 5.01 2 Yes Yes 0 5 1 2
L:L:R8 R:R:S188 9.22 2 Yes No 0 4 1 2
L:L:W9 R:R:S188 3.71 2 Yes No 0 4 1 2
R:R:I194 R:R:L265 4.28 2 Yes Yes 4 5 2 2
R:R:I194 R:R:Y268 3.63 2 Yes No 4 5 2 2
L:L:W9 R:R:I194 9.4 2 Yes Yes 0 4 1 2
L:L:W9 R:R:L197 3.42 2 Yes No 0 5 1 2
R:R:F261 R:R:F262 5.36 2 Yes No 5 5 1 2
R:R:F261 R:R:L265 9.74 2 Yes Yes 5 5 1 2
R:R:F261 R:R:F284 3.22 2 Yes Yes 5 3 1 2
R:R:F261 R:R:I291 5.02 2 Yes No 5 6 1 2
L:L:?7 R:R:F261 3.11 2 Yes Yes 0 5 0 1
R:R:F262 R:R:L265 3.65 2 No Yes 5 5 2 2
L:L:W9 R:R:L265 4.56 2 Yes Yes 0 5 1 2
L:L:W9 R:R:Y268 5.79 2 Yes No 0 5 1 2
L:L:?7 L:L:R8 6.2 2 Yes Yes 0 0 0 1
L:L:?7 L:L:W9 2.91 2 Yes Yes 0 0 0 1
L:L:R8 L:L:W9 9 2 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.60
Average Nodes In Shell20.00
Average Hubs In Shell11.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7W40 A Peptide Bombesin BB2 Homo Sapiens Bombesin - chim(NtGi1L-Gq)/Beta1/Gamma2 3 2023-02-22 10.1073/pnas.2216230120

A 2D representation of the interactions of DPN in 7W40
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Q2 R:R:R100 4.67 0 Yes Yes 0 5 1 2
R:R:F301 R:R:Y101 5.16 1 Yes Yes 4 4 2 2
L:L:W3 R:R:Y101 15.43 1 No Yes 0 4 1 2
R:R:D104 R:R:F193 8.36 1 No No 4 1 1 1
L:L:?1 R:R:D104 3.47 1 Yes No 0 4 0 1
L:L:Q2 R:R:W106 8.76 0 Yes Yes 0 8 1 2
R:R:E186 R:R:S188 5.75 0 Yes No 3 3 1 2
R:R:E186 R:R:T189 18.34 0 Yes No 3 1 1 2
R:R:E186 R:R:T296 8.47 0 Yes No 3 3 1 2
L:L:?1 R:R:E186 7.9 1 Yes Yes 0 3 0 1
L:L:?1 R:R:F193 5.18 1 Yes No 0 1 0 1
L:L:Q2 R:R:S195 10.11 0 Yes No 0 4 1 2
L:L:W3 R:R:F301 16.04 1 No Yes 0 4 1 2
L:L:?1 L:L:Q2 5.67 1 Yes Yes 0 0 0 1
L:L:?1 L:L:W3 6.79 1 Yes No 0 0 0 1
L:L:?1 L:L:A4 4.02 1 Yes No 0 0 0 1
R:R:D104 R:R:R105 2.38 1 No No 4 4 1 2
R:R:E186 R:R:E187 1.27 0 Yes No 3 4 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.50
Average Nodes In Shell17.00
Average Hubs In Shell7.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XAU A Peptide Somatostatin SST2 Homo sapiens Octreotide - Gi1/Beta1/Gamma2 2.97 2022-08-31 10.1038/s41421-022-00405-2

A 2D representation of the interactions of DPN in 7XAU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N186 R:R:Q187 23.77 0 No No 1 2 2 1
R:R:Q187 R:R:W188 7.67 0 No No 2 2 1 2
L:L:?1 R:R:Q187 3.4 1 Yes No 0 2 0 1
L:L:?1 R:R:I284 4.86 1 Yes No 0 1 0 1
R:R:P286 R:R:S285 3.56 0 No No 2 2 1 2
L:L:?1 R:R:P286 8.39 1 Yes No 0 2 0 1
R:R:L290 R:R:T287 8.84 0 No No 4 1 1 2
R:R:L290 R:R:M293 7.07 0 No No 4 4 1 2
L:L:C2 R:R:F294 13.97 1 No Yes 0 4 1 2
L:L:C7 R:R:F294 5.59 1 No Yes 0 4 1 2
L:L:?1 L:L:C2 12.16 1 Yes No 0 0 0 1
L:L:?1 L:L:C7 5.4 1 Yes No 0 0 0 1
L:L:C2 L:L:C7 7.28 1 No No 0 0 1 1
L:L:?1 R:R:S279 2.56 1 Yes No 0 4 0 1
L:L:?1 R:R:L290 2.36 1 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.59
Average Nodes In Shell14.00
Average Hubs In Shell2.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell9.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y24 A Peptide Somatostatin SST2 Homo sapiens Octreotide - Go/Beta1/Gamma2 3.25 2022-10-19 10.1038/s41589-022-01130-3

A 2D representation of the interactions of DPN in 7Y24
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:C2 4.05 1 No Yes 0 0 0 1
L:L:?1 L:L:C7 6.75 1 No No 0 0 0 1
L:L:?1 L:L:T8 6.27 1 No No 0 0 0 1
L:L:C2 L:L:C7 7.28 1 Yes No 0 0 1 1
L:L:C2 R:R:F294 12.57 1 Yes No 0 4 1 2
L:L:C7 R:R:K291 6.47 1 No No 0 3 1 2
L:L:T8 R:R:N186 4.39 0 No Yes 0 1 1 2
L:L:T8 R:R:Q187 5.67 0 No No 0 2 1 2
L:L:C2 R:R:S279 1.72 1 Yes No 0 4 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.69
Average Nodes In Shell9.00
Average Hubs In Shell2.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y26 A Peptide Somatostatin SST2 Homo sapiens Octreotide - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.3 2022-10-19 10.1038/s41589-022-01130-3

A 2D representation of the interactions of DPN in 7Y26
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:C2 6.75 0 No No 0 0 0 1
L:L:?1 L:L:T8 5.02 0 No Yes 0 0 0 1
L:L:C2 L:L:C7 7.28 1 No Yes 0 0 1 2
L:L:C2 R:R:F294 9.78 1 No Yes 0 4 1 2
L:L:C7 L:L:T8 1.69 1 Yes Yes 0 0 2 1
L:L:C7 R:R:K291 6.47 1 Yes No 0 3 2 2
L:L:C7 R:R:F294 5.59 1 Yes Yes 0 4 2 2
L:L:T8 R:R:R184 9.06 1 Yes Yes 0 2 1 2
L:L:T8 R:R:N186 4.39 1 Yes No 0 1 1 2
L:L:T8 R:R:Q187 8.5 1 Yes No 0 2 1 2
L:L:T8 R:R:K291 3 1 Yes No 0 3 1 2
R:R:N186 R:R:R184 12.05 1 No Yes 1 2 2 2
L:L:?1 R:R:S279 1.28 0 No No 0 4 0 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength4.35
Average Nodes In Shell10.00
Average Hubs In Shell4.00
Average Links In Shell13.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y27 A Peptide Somatostatin SST2 Homo sapiens Somatostatin-14 - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.48 2022-10-19 10.1038/s41589-022-01130-3

A 2D representation of the interactions of DPN in 7Y27
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:C2 6.75 0 No No 0 0 0 1
L:L:?1 L:L:T8 5.02 0 No Yes 0 0 0 1
L:L:C2 L:L:C7 7.28 1 No Yes 0 0 1 2
L:L:C2 R:R:F294 9.78 1 No Yes 0 4 1 2
L:L:C7 L:L:T8 1.69 1 Yes Yes 0 0 2 1
L:L:C7 R:R:K291 6.47 1 Yes No 0 3 2 2
L:L:C7 R:R:F294 5.59 1 Yes Yes 0 4 2 2
L:L:T8 R:R:R184 9.06 1 Yes Yes 0 2 1 2
L:L:T8 R:R:N186 4.39 1 Yes No 0 1 1 2
L:L:T8 R:R:Q187 8.5 1 Yes No 0 2 1 2
L:L:T8 R:R:K291 3 1 Yes No 0 3 1 2
R:R:N186 R:R:R184 12.05 1 No Yes 1 2 2 2
L:L:?1 R:R:S279 1.28 0 No No 0 4 0 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength4.35
Average Nodes In Shell10.00
Average Hubs In Shell4.00
Average Links In Shell13.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YAE A Peptide Somatostatin SST2 Homo Sapiens Octreotide - Gi1/Beta1/Gamma2 3.37 2023-04-19  10.1038/s41467-023-36673-z

A 2D representation of the interactions of DPN in 7YAE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?8 R:R:T194 7.65 19 Yes No 0 4 1 2
R:R:I284 R:R:L290 4.28 0 No No 1 4 1 2
R:R:P286 R:R:S285 5.34 0 No No 2 2 1 2
L:L:?1 R:R:P286 5.59 19 Yes No 0 2 0 1
L:L:C7 R:R:F294 2.79 19 Yes Yes 0 4 1 2
L:L:?1 L:L:C2 10.81 19 Yes No 0 0 0 1
L:L:?1 L:L:C7 13.51 19 Yes Yes 0 0 0 1
L:L:?1 L:L:?8 16.81 19 Yes Yes 0 0 0 1
L:L:C2 L:L:C7 7.28 19 No Yes 0 0 1 1
L:L:?8 L:L:C7 4.12 19 Yes Yes 0 0 1 1
L:L:?1 R:R:I284 2.43 19 Yes No 0 1 0 1
L:L:?8 R:R:S192 1.95 19 Yes No 0 4 1 2
L:L:C2 R:R:S279 1.72 19 No No 0 4 1 2
L:L:C7 R:R:K291 1.62 19 Yes No 0 3 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.83
Average Nodes In Shell13.00
Average Hubs In Shell4.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FEG A Peptide Opioid KOP Homo Sapiens PRD_002517 - Gi1/Beta1/Gamma2 2.54 2023-12-06 10.1038/s41467-023-43718-w

A 2D representation of the interactions of DPN in 8FEG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q115 R:R:Y66 6.76 1 Yes Yes 7 6 1 2
R:R:Y119 R:R:Y66 5.96 1 Yes Yes 4 6 2 2
R:R:Y320 R:R:Y66 6.95 1 Yes Yes 6 6 2 2
R:R:Q115 R:R:Y119 16.91 1 Yes Yes 7 4 1 2
R:R:Q115 R:R:Y320 5.64 1 Yes Yes 7 6 1 2
L:L:?9 R:R:Q115 7.93 1 Yes Yes 0 7 0 1
R:R:V118 R:R:Y119 3.79 0 No Yes 5 4 2 2
L:L:T8 R:R:V118 7.93 1 Yes No 0 5 1 2
R:R:I316 R:R:Y119 8.46 1 Yes Yes 5 4 2 2
R:R:C131 R:R:W124 6.53 1 No Yes 9 8 2 2
R:R:V134 R:R:W124 3.68 0 No Yes 6 8 1 2
R:R:C210 R:R:W124 20.89 1 Yes Yes 9 8 1 2
L:L:T8 R:R:W124 3.64 1 Yes Yes 0 8 1 2
R:R:C131 R:R:C210 7.28 1 No Yes 9 9 2 1
L:L:?9 R:R:V134 5.07 1 Yes No 0 6 0 1
L:L:?9 R:R:L135 4.71 1 Yes No 0 4 0 1
L:L:?10 R:R:D138 13.51 1 Yes No 0 6 1 2
L:L:?10 R:R:M142 8.21 1 Yes No 0 7 1 2
L:L:T8 R:R:C210 5.07 1 Yes Yes 0 9 1 1
L:L:?9 R:R:C210 5.4 1 Yes Yes 0 9 0 1
R:R:I294 R:R:K227 4.36 1 No Yes 5 4 2 2
L:L:?10 R:R:K227 4.68 1 Yes Yes 0 4 1 2
L:L:?10 R:R:V230 4.94 1 Yes No 0 5 1 2
R:R:I290 R:R:I316 4.42 1 No Yes 6 5 2 2
L:L:?10 R:R:I290 8.29 1 Yes No 0 6 1 2
L:L:?10 R:R:I294 20.13 1 Yes No 0 5 1 2
R:R:I316 R:R:Y312 7.25 1 Yes Yes 5 4 2 2
L:L:?10 R:R:Y312 3.89 1 Yes Yes 0 4 1 2
R:R:I316 R:R:Y320 4.84 1 Yes Yes 5 6 2 2
L:L:?10 R:R:I316 7.1 1 Yes Yes 0 5 1 2
L:L:?10 R:R:Y320 10.7 1 Yes Yes 0 6 1 2
L:L:?9 L:L:T8 10.04 1 Yes Yes 0 0 0 1
L:L:?10 L:L:?9 18.57 1 Yes Yes 0 0 1 0
L:L:?10 R:R:G319 2.84 1 Yes No 0 7 1 2
R:R:G197 R:R:L135 1.71 0 No No 4 4 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.62
Average Nodes In Shell23.00
Average Hubs In Shell12.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.20
Average Number Of Links With An Hub3.73
Average Interaction Strength7.42
Average Nodes In Shell18.73
Average Hubs In Shell8.13
Average Links In Shell25.33
Average Links Mediated by Hubs In Shell22.93

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)