Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7AUE | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | chim(NtGi1L-Gs)/Beta1/Gamma2 | 2.97 | 2021-04-28 | 10.1126/science.abf7958 |
![](/psngpcr/ligands/DPN/DPN_7AUE_L_L_6.png)
A 2D representation of the interactions of DPN in 7AUE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I129 | R:R:N97 | 4.25 | 11 | Yes | No | 5 | 6 | 1 | 2 | R:R:E100 | R:R:I125 | 6.83 | 11 | Yes | No | 5 | 5 | 1 | 2 | R:R:D126 | R:R:E100 | 9.09 | 11 | Yes | Yes | 4 | 5 | 1 | 1 | R:R:E100 | R:R:I129 | 2.73 | 11 | Yes | Yes | 5 | 5 | 1 | 1 | L:L:?6 | R:R:E100 | 5.64 | 11 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:D122 | R:R:D126 | 9.31 | 0 | No | Yes | 8 | 4 | 2 | 1 | L:L:?6 | R:R:D126 | 10.4 | 11 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:R7 | R:R:D126 | 5.96 | 11 | Yes | Yes | 0 | 4 | 1 | 1 | R:R:I129 | R:R:L133 | 2.85 | 11 | Yes | Yes | 5 | 5 | 1 | 2 | L:L:?6 | R:R:I129 | 15.79 | 11 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R7 | R:R:I185 | 6.26 | 11 | Yes | No | 0 | 5 | 1 | 2 | L:L:R7 | R:R:S188 | 9.22 | 11 | Yes | No | 0 | 4 | 1 | 2 | L:L:W8 | R:R:S188 | 8.65 | 0 | No | No | 0 | 4 | 1 | 2 | L:L:W8 | R:R:I194 | 5.87 | 0 | No | No | 0 | 4 | 1 | 2 | R:R:F284 | R:R:L288 | 4.87 | 18 | Yes | No | 3 | 4 | 2 | 1 | L:L:?6 | R:R:L288 | 3.53 | 11 | Yes | No | 0 | 4 | 0 | 1 | L:L:?6 | L:L:R7 | 7.24 | 11 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?6 | L:L:W8 | 2.91 | 11 | Yes | No | 0 | 0 | 0 | 1 | L:L:R7 | R:R:N123 | 2.41 | 11 | Yes | No | 0 | 5 | 1 | 2 | R:R:I129 | R:R:S96 | 1.55 | 11 | Yes | No | 5 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 7.59 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 20.00 | Average Links Mediated by Hubs In Shell | 18.00 |
| ![](/psngpcr/ligands/DPN/DPN_7AUE_L_L_6_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7AUE_L_L_6_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F4F | A | Peptide | Melanocortin | MC1 | Homo sapiens | Afamelanotide | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.9 | 2021-09-08 | 10.1038/s41422-021-00557-y |
![](/psngpcr/ligands/DPN/DPN_7F4F_L_L_7.png)
A 2D representation of the interactions of DPN in 7F4F colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:S90 | R:R:T124 | 4.8 | 0 | No | No | 5 | 5 | 2 | 1 | R:R:D117 | R:R:E94 | 3.9 | 2 | Yes | Yes | 6 | 4 | 2 | 1 | R:R:E94 | R:R:I120 | 5.47 | 2 | Yes | No | 4 | 5 | 1 | 2 | R:R:D121 | R:R:E94 | 6.5 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?7 | R:R:E94 | 7.9 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D117 | R:R:D121 | 10.65 | 2 | Yes | Yes | 6 | 5 | 2 | 1 | L:L:R8 | R:R:D117 | 7.15 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | R:R:I180 | R:R:N118 | 4.25 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | L:L:R8 | R:R:N118 | 8.44 | 2 | Yes | Yes | 0 | 4 | 1 | 2 | R:R:D121 | R:R:I180 | 4.2 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | L:L:?7 | R:R:D121 | 15.02 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R8 | R:R:D121 | 14.29 | 2 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:?7 | R:R:T124 | 11.29 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:?7 | R:R:C125 | 6.75 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:M128 | R:R:W254 | 5.82 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:I287 | R:R:M128 | 4.37 | 2 | No | Yes | 7 | 5 | 2 | 1 | L:L:?7 | R:R:M128 | 8.42 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R8 | R:R:I180 | 8.77 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:R8 | R:R:Y183 | 11.32 | 2 | Yes | No | 0 | 3 | 1 | 2 | L:L:W9 | R:R:Y183 | 5.79 | 2 | Yes | No | 0 | 3 | 1 | 2 | L:L:W9 | R:R:V188 | 3.68 | 2 | Yes | No | 0 | 4 | 1 | 2 | R:R:L189 | R:R:L261 | 5.54 | 2 | No | Yes | 4 | 5 | 2 | 2 | L:L:W9 | R:R:L189 | 13.67 | 2 | Yes | No | 0 | 4 | 1 | 2 | R:R:L192 | R:R:L261 | 4.15 | 2 | No | Yes | 5 | 5 | 2 | 2 | L:L:W9 | R:R:L192 | 4.56 | 2 | Yes | No | 0 | 5 | 1 | 2 | R:R:I287 | R:R:W254 | 11.74 | 2 | No | Yes | 7 | 7 | 2 | 2 | R:R:F257 | R:R:F258 | 9.65 | 0 | Yes | No | 5 | 5 | 1 | 2 | R:R:F257 | R:R:L261 | 8.53 | 0 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F257 | R:R:F280 | 4.29 | 0 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:F257 | R:R:I287 | 5.02 | 0 | Yes | No | 5 | 7 | 1 | 2 | L:L:?7 | R:R:F257 | 6.22 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:W9 | R:R:L261 | 4.56 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:F280 | R:R:L284 | 10.96 | 0 | Yes | No | 4 | 4 | 2 | 1 | L:L:?7 | R:R:L284 | 4.71 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?7 | L:L:R8 | 12.41 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?7 | L:L:W9 | 6.79 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R8 | L:L:W9 | 6 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | R:R:C125 | R:R:S176 | 3.44 | 0 | No | No | 4 | 7 | 1 | 2 | R:R:M128 | R:R:V87 | 3.04 | 2 | Yes | No | 5 | 8 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 8.83 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 39.00 | Average Links Mediated by Hubs In Shell | 37.00 |
| ![](/psngpcr/ligands/DPN/DPN_7F4F_L_L_7_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7F4F_L_L_7_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F4H | A | Peptide | Melanocortin | MC1 | Homo sapiens | Afamelanotide | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.7 | 2021-09-08 | 10.1038/s41422-021-00557-y |
![](/psngpcr/ligands/DPN/DPN_7F4H_L_L_7.png)
A 2D representation of the interactions of DPN in 7F4H colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:S90 | R:R:T124 | 6.4 | 0 | No | Yes | 5 | 5 | 2 | 1 | R:R:N91 | R:R:T124 | 8.77 | 2 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:D121 | R:R:E94 | 6.5 | 2 | Yes | No | 5 | 4 | 1 | 1 | L:L:H6 | R:R:E94 | 7.39 | 2 | Yes | No | 0 | 4 | 2 | 1 | L:L:?7 | R:R:E94 | 12.41 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:D117 | R:R:D121 | 9.31 | 2 | No | Yes | 6 | 5 | 2 | 1 | L:L:R8 | R:R:D117 | 5.96 | 2 | Yes | No | 0 | 6 | 1 | 2 | R:R:I180 | R:R:N118 | 4.25 | 2 | Yes | No | 5 | 4 | 1 | 2 | L:L:?7 | R:R:D121 | 18.48 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R8 | R:R:D121 | 14.29 | 2 | Yes | Yes | 0 | 5 | 1 | 1 | R:R:I180 | R:R:V122 | 4.61 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:M128 | R:R:T124 | 4.52 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | L:L:?7 | R:R:T124 | 11.29 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:C125 | R:R:S176 | 6.89 | 2 | No | No | 4 | 7 | 1 | 2 | R:R:C125 | R:R:I180 | 6.55 | 2 | No | Yes | 4 | 5 | 1 | 1 | L:L:?7 | R:R:C125 | 4.05 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:M128 | R:R:W254 | 5.82 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:I287 | R:R:M128 | 4.37 | 2 | Yes | Yes | 7 | 5 | 2 | 1 | L:L:?7 | R:R:M128 | 4.81 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?7 | R:R:I180 | 4.86 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R8 | R:R:I180 | 5.01 | 2 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:R8 | R:R:Y183 | 23.66 | 2 | Yes | No | 0 | 3 | 1 | 2 | L:L:W9 | R:R:Y183 | 5.79 | 2 | Yes | No | 0 | 3 | 1 | 2 | R:R:L189 | R:R:L261 | 4.15 | 2 | Yes | No | 4 | 5 | 2 | 2 | L:L:W9 | R:R:L189 | 10.25 | 2 | Yes | Yes | 0 | 4 | 1 | 2 | R:R:F258 | R:R:W254 | 6.01 | 2 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:I287 | R:R:W254 | 8.22 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:F257 | R:R:F258 | 10.72 | 0 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F257 | R:R:L261 | 13.4 | 0 | Yes | No | 5 | 5 | 1 | 2 | R:R:F257 | R:R:F280 | 6.43 | 0 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:F257 | R:R:I287 | 6.28 | 0 | Yes | Yes | 5 | 7 | 1 | 2 | L:L:?7 | R:R:F257 | 6.22 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:W9 | R:R:L261 | 6.83 | 2 | Yes | No | 0 | 5 | 1 | 2 | L:L:?7 | L:L:R8 | 11.38 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?7 | L:L:W9 | 6.79 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R8 | L:L:W9 | 7 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | R:R:D121 | R:R:I120 | 2.8 | 2 | Yes | No | 5 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.92 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 37.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/DPN/DPN_7F4H_L_L_7_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7F4H_L_L_7_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F54 | A | Peptide | Melanocortin | MC4 | Homo sapiens | Afamelanotide | - | Gs/Beta1/Gamma2 | 3 | 2021-11-03 | 10.1038/s41422-021-00552-3 |
![](/psngpcr/ligands/DPN/DPN_7F54_L_L_7.png)
A 2D representation of the interactions of DPN in 7F54 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F284 | R:R:Q43 | 3.51 | 5 | Yes | No | 3 | 3 | 1 | 2 | R:R:I129 | R:R:S96 | 6.19 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:I129 | R:R:N97 | 14.16 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:D122 | R:R:E100 | 3.9 | 5 | No | Yes | 8 | 5 | 2 | 1 | R:R:E100 | R:R:I125 | 9.56 | 5 | Yes | No | 5 | 5 | 1 | 2 | R:R:D126 | R:R:E100 | 7.8 | 5 | Yes | Yes | 4 | 5 | 1 | 1 | L:L:?4 | R:R:E100 | 7.52 | 5 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:?7 | R:R:E100 | 5.64 | 5 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:D122 | R:R:D126 | 6.65 | 5 | No | Yes | 8 | 4 | 2 | 1 | L:L:?4 | R:R:D122 | 23.09 | 5 | Yes | No | 0 | 8 | 2 | 2 | R:R:D126 | R:R:I185 | 4.2 | 5 | Yes | Yes | 4 | 5 | 1 | 2 | L:L:?7 | R:R:D126 | 11.55 | 5 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:R8 | R:R:D126 | 10.72 | 5 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?7 | R:R:I129 | 12.15 | 5 | Yes | No | 0 | 5 | 0 | 1 | L:L:R8 | R:R:I185 | 8.77 | 5 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:R8 | R:R:S188 | 11.86 | 5 | Yes | No | 0 | 4 | 1 | 2 | R:R:I194 | R:R:L265 | 7.14 | 5 | No | No | 4 | 5 | 2 | 2 | L:L:W9 | R:R:I194 | 11.74 | 5 | Yes | No | 0 | 4 | 1 | 2 | L:L:W9 | R:R:L197 | 3.42 | 5 | Yes | No | 0 | 5 | 1 | 2 | R:R:F261 | R:R:F262 | 5.36 | 5 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:L265 | 4.87 | 5 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:F284 | 6.43 | 5 | Yes | Yes | 5 | 3 | 1 | 1 | R:R:F261 | R:R:I291 | 6.28 | 5 | Yes | No | 5 | 6 | 1 | 2 | L:L:?7 | R:R:F261 | 5.18 | 5 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F284 | R:R:H264 | 10.18 | 5 | Yes | No | 3 | 4 | 1 | 2 | L:L:W9 | R:R:L265 | 4.56 | 5 | Yes | No | 0 | 5 | 1 | 2 | L:L:W9 | R:R:Y268 | 16.4 | 5 | Yes | No | 0 | 5 | 1 | 2 | R:R:F284 | R:R:L288 | 13.4 | 5 | Yes | No | 3 | 4 | 1 | 2 | L:L:?7 | R:R:F284 | 6.22 | 5 | Yes | Yes | 0 | 3 | 0 | 1 | L:L:G10 | R:R:F284 | 6.02 | 0 | No | Yes | 0 | 3 | 2 | 1 | L:L:?7 | L:L:R8 | 11.38 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?7 | L:L:W9 | 3.88 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R8 | L:L:W9 | 9 | 5 | Yes | Yes | 0 | 0 | 1 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 8.00 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 30.00 |
| ![](/psngpcr/ligands/DPN/DPN_7F54_L_L_7_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7F54_L_L_7_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F55 | A | Peptide | Melanocortin | MC4 | Homo sapiens | Bremelanotide | - | Gs/Beta1/Gamma2 | 3.1 | 2021-11-03 | 10.1038/s41422-021-00552-3 |
![](/psngpcr/ligands/DPN/DPN_7F55_L_L_4.png)
A 2D representation of the interactions of DPN in 7F55 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F284 | R:R:Q43 | 3.51 | 4 | Yes | No | 3 | 3 | 1 | 2 | R:R:I129 | R:R:S96 | 4.64 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:I129 | R:R:N97 | 9.91 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:D122 | R:R:E100 | 3.9 | 4 | No | Yes | 8 | 5 | 2 | 1 | R:R:E100 | R:R:I125 | 9.56 | 4 | Yes | No | 5 | 5 | 1 | 2 | R:R:D126 | R:R:E100 | 7.8 | 4 | Yes | Yes | 4 | 5 | 1 | 1 | L:L:?1 | R:R:E100 | 7.52 | 4 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:?4 | R:R:E100 | 5.64 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:D122 | R:R:D126 | 7.98 | 4 | No | Yes | 8 | 4 | 2 | 1 | L:L:?1 | R:R:D122 | 23.09 | 4 | Yes | No | 0 | 8 | 2 | 2 | R:R:D126 | R:R:I185 | 4.2 | 4 | Yes | Yes | 4 | 5 | 1 | 2 | L:L:?4 | R:R:D126 | 15.02 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:R5 | R:R:D126 | 8.34 | 4 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?4 | R:R:I129 | 12.15 | 4 | Yes | No | 0 | 5 | 0 | 1 | L:L:R5 | R:R:I185 | 3.76 | 4 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:R5 | R:R:S188 | 10.54 | 4 | Yes | No | 0 | 4 | 1 | 2 | L:L:W6 | R:R:S188 | 6.18 | 4 | Yes | No | 0 | 4 | 1 | 2 | R:R:I194 | R:R:L265 | 7.14 | 4 | No | No | 4 | 5 | 2 | 2 | L:L:W6 | R:R:I194 | 8.22 | 4 | Yes | No | 0 | 4 | 1 | 2 | R:R:F261 | R:R:F262 | 5.36 | 4 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:L265 | 4.87 | 4 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:F284 | 6.43 | 4 | Yes | Yes | 5 | 3 | 1 | 1 | R:R:F261 | R:R:I291 | 6.28 | 4 | Yes | No | 5 | 6 | 1 | 2 | L:L:?4 | R:R:F261 | 5.18 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F284 | R:R:H264 | 10.18 | 4 | Yes | No | 3 | 4 | 1 | 2 | L:L:W6 | R:R:L265 | 3.42 | 4 | Yes | No | 0 | 5 | 1 | 2 | L:L:W6 | R:R:Y268 | 13.5 | 4 | Yes | No | 0 | 5 | 1 | 2 | R:R:F284 | R:R:L288 | 13.4 | 4 | Yes | No | 3 | 4 | 1 | 2 | L:L:?4 | R:R:F284 | 5.18 | 4 | Yes | Yes | 0 | 3 | 0 | 1 | L:L:K7 | R:R:F284 | 11.17 | 0 | No | Yes | 0 | 3 | 2 | 1 | L:L:?4 | L:L:R5 | 5.17 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:W6 | 5.82 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R5 | L:L:W6 | 4 | 4 | Yes | Yes | 0 | 0 | 1 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.74 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 30.00 |
| ![](/psngpcr/ligands/DPN/DPN_7F55_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7F55_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F9Z | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | GHRP-6 | - | chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 | 3.2 | 2021-08-18 | 10.1038/s41467-021-25364-2 |
![](/psngpcr/ligands/DPN/DPN_7F9Z_L_L_5.png)
A 2D representation of the interactions of DPN in 7F9Z colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:?3 | 30.44 | 3 | Yes | Yes | 0 | 0 | 2 | 2 | L:L:?2 | L:L:?6 | 9.62 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?2 | R:R:D99 | 5.43 | 3 | Yes | No | 0 | 6 | 2 | 2 | L:L:?2 | R:R:F309 | 9.75 | 3 | Yes | Yes | 0 | 5 | 2 | 2 | L:L:?3 | L:L:?4 | 18.04 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?3 | R:R:F286 | 9.91 | 3 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:?4 | L:L:?5 | 14.15 | 3 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?4 | L:L:?6 | 9.62 | 3 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?4 | R:R:F286 | 3.9 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?4 | R:R:S308 | 4.81 | 3 | Yes | No | 0 | 7 | 1 | 2 | L:L:?4 | R:R:F309 | 8.78 | 3 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?5 | L:L:?6 | 28.63 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | L:L:?7 | 5.87 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | R:R:E124 | 5.64 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?5 | R:R:L181 | 11.78 | 3 | Yes | No | 0 | 4 | 0 | 1 | L:L:?5 | R:R:P200 | 6.99 | 3 | Yes | No | 0 | 4 | 0 | 1 | L:L:?5 | R:R:M213 | 12.03 | 3 | Yes | No | 0 | 5 | 0 | 1 | L:L:?5 | R:R:R283 | 27.92 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?6 | L:L:?7 | 23.95 | 3 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?6 | R:R:D99 | 4.71 | 3 | Yes | No | 0 | 6 | 1 | 2 | L:L:?6 | R:R:Q120 | 21.95 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?6 | R:R:E124 | 6.9 | 3 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?6 | R:R:I178 | 4.95 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:?7 | R:R:Q120 | 9.95 | 3 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?7 | R:R:E124 | 13.21 | 3 | Yes | Yes | 0 | 4 | 1 | 1 | R:R:D99 | R:R:F309 | 9.55 | 3 | No | Yes | 6 | 5 | 2 | 2 | R:R:E124 | R:R:Y128 | 4.49 | 3 | Yes | No | 4 | 6 | 1 | 2 | R:R:E124 | R:R:I178 | 6.83 | 3 | Yes | No | 4 | 4 | 1 | 2 | R:R:E124 | R:R:R283 | 5.82 | 3 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:S217 | R:R:Y128 | 5.09 | 0 | No | No | 6 | 6 | 2 | 2 | R:R:L181 | R:R:M213 | 7.07 | 3 | No | No | 4 | 5 | 1 | 1 | R:R:R283 | R:R:S217 | 7.91 | 3 | Yes | No | 6 | 6 | 1 | 2 | R:R:F279 | R:R:R283 | 8.55 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 14.13 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 31.00 |
| ![](/psngpcr/ligands/DPN/DPN_7F9Z_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7F9Z_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7PIU | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | Gs/Beta1/Gamma2 | 2.58 | 2021-11-17 | 10.1038/s41422-021-00569-8 |
![](/psngpcr/ligands/DPN/DPN_7PIU_L_L_5.png)
A 2D representation of the interactions of DPN in 7PIU colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F284 | R:R:Q43 | 3.51 | 2 | Yes | No | 3 | 3 | 1 | 2 | R:R:N285 | R:R:Q43 | 7.92 | 2 | No | No | 4 | 3 | 2 | 2 | R:R:F51 | R:R:T101 | 9.08 | 2 | Yes | No | 6 | 6 | 2 | 2 | R:R:F51 | R:R:N285 | 3.62 | 2 | Yes | No | 6 | 4 | 2 | 2 | L:L:H4 | R:R:F51 | 22.63 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | R:R:I129 | R:R:S96 | 4.64 | 0 | Yes | No | 5 | 6 | 1 | 2 | R:R:I129 | R:R:N97 | 11.33 | 0 | Yes | No | 5 | 6 | 1 | 2 | R:R:E100 | R:R:I125 | 4.1 | 0 | No | No | 5 | 5 | 1 | 2 | L:L:?5 | R:R:E100 | 4.51 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:H4 | R:R:T101 | 6.85 | 2 | Yes | No | 0 | 6 | 1 | 2 | R:R:D122 | R:R:D126 | 3.99 | 2 | No | Yes | 8 | 4 | 2 | 1 | L:L:R6 | R:R:D122 | 3.57 | 2 | Yes | No | 0 | 8 | 1 | 2 | L:L:R6 | R:R:N123 | 4.82 | 2 | Yes | No | 0 | 5 | 1 | 2 | R:R:D126 | R:R:I185 | 4.2 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | L:L:?5 | R:R:D126 | 10.4 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:R6 | R:R:D126 | 16.68 | 2 | Yes | Yes | 0 | 4 | 1 | 1 | R:R:I129 | R:R:S132 | 3.1 | 0 | Yes | No | 5 | 6 | 1 | 2 | L:L:?5 | R:R:I129 | 14.58 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R6 | R:R:I185 | 6.26 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:R6 | R:R:S188 | 7.91 | 2 | Yes | No | 0 | 4 | 1 | 2 | L:L:W7 | R:R:S188 | 3.71 | 2 | Yes | No | 0 | 4 | 2 | 2 | R:R:F261 | R:R:F262 | 7.5 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F261 | R:R:L265 | 6.09 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F261 | R:R:F284 | 4.29 | 2 | Yes | Yes | 5 | 3 | 1 | 1 | R:R:F261 | R:R:I291 | 3.77 | 2 | Yes | No | 5 | 6 | 1 | 2 | L:L:?5 | R:R:F261 | 6.22 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F262 | R:R:L265 | 3.65 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:F284 | R:R:H264 | 15.84 | 2 | Yes | No | 3 | 4 | 1 | 2 | L:L:W7 | R:R:L265 | 3.42 | 2 | Yes | Yes | 0 | 5 | 2 | 2 | R:R:F284 | R:R:L288 | 9.74 | 2 | Yes | No | 3 | 4 | 1 | 1 | L:L:?5 | R:R:F284 | 4.15 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | L:L:C8 | R:R:F284 | 8.38 | 0 | No | Yes | 0 | 3 | 2 | 1 | L:L:H4 | R:R:N285 | 5.1 | 2 | Yes | No | 0 | 4 | 1 | 2 | L:L:?5 | R:R:L288 | 3.53 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?3 | L:L:H4 | 14.39 | 0 | No | Yes | 0 | 0 | 2 | 1 | L:L:?5 | L:L:H4 | 3.28 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | L:L:R6 | 6.2 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R6 | L:L:W7 | 13.99 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 6.61 | Average Nodes In Shell | 28.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/DPN/DPN_7PIU_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7PIU_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7PIV | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | Gs/Beta1/Gamma2 | 2.86 | 2021-11-17 | 10.1038/s41422-021-00569-8 |
![](/psngpcr/ligands/DPN/DPN_7PIV_L_L_7.png)
A 2D representation of the interactions of DPN in 7PIV colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I129 | R:R:S96 | 6.19 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:D122 | R:R:E100 | 3.9 | 2 | No | Yes | 8 | 5 | 2 | 1 | R:R:E100 | R:R:I125 | 8.2 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:D126 | R:R:E100 | 5.2 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | L:L:?4 | R:R:E100 | 5.01 | 2 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:?7 | R:R:E100 | 3.38 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:D122 | R:R:D126 | 6.65 | 2 | No | Yes | 8 | 4 | 2 | 1 | L:L:?4 | R:R:D122 | 16.68 | 2 | Yes | No | 0 | 8 | 2 | 2 | R:R:D126 | R:R:I185 | 4.2 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | L:L:?7 | R:R:D126 | 4.62 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:R8 | R:R:D126 | 14.29 | 2 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?7 | R:R:I129 | 13.36 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:R8 | R:R:I185 | 5.01 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:R8 | R:R:S188 | 9.22 | 2 | Yes | No | 0 | 4 | 1 | 2 | L:L:W9 | R:R:S188 | 3.71 | 2 | Yes | No | 0 | 4 | 1 | 2 | R:R:I194 | R:R:L265 | 4.28 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:I194 | R:R:Y268 | 3.63 | 2 | Yes | No | 4 | 5 | 2 | 2 | L:L:W9 | R:R:I194 | 9.4 | 2 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:W9 | R:R:L197 | 3.42 | 2 | Yes | No | 0 | 5 | 1 | 2 | R:R:F261 | R:R:F262 | 5.36 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:L265 | 9.74 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F261 | R:R:F284 | 3.22 | 2 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:F261 | R:R:I291 | 5.02 | 2 | Yes | No | 5 | 6 | 1 | 2 | L:L:?7 | R:R:F261 | 3.11 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F262 | R:R:L265 | 3.65 | 2 | No | Yes | 5 | 5 | 2 | 2 | L:L:W9 | R:R:L265 | 4.56 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:W9 | R:R:Y268 | 5.79 | 2 | Yes | No | 0 | 5 | 1 | 2 | L:L:?7 | L:L:R8 | 6.2 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?7 | L:L:W9 | 2.91 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R8 | L:L:W9 | 9 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 5.60 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 30.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/DPN/DPN_7PIV_L_L_7_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7PIV_L_L_7_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7W40 | A | Peptide | Bombesin | BB2 | Homo Sapiens | Bombesin | - | chim(NtGi1L-Gq)/Beta1/Gamma2 | 3 | 2023-02-22 | 10.1073/pnas.2216230120 |
![](/psngpcr/ligands/DPN/DPN_7W40_L_L_1.png)
A 2D representation of the interactions of DPN in 7W40 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:Q2 | R:R:R100 | 4.67 | 0 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:F301 | R:R:Y101 | 5.16 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | L:L:W3 | R:R:Y101 | 15.43 | 1 | No | Yes | 0 | 4 | 1 | 2 | R:R:D104 | R:R:F193 | 8.36 | 1 | No | No | 4 | 1 | 1 | 1 | L:L:?1 | R:R:D104 | 3.47 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:Q2 | R:R:W106 | 8.76 | 0 | Yes | Yes | 0 | 8 | 1 | 2 | R:R:E186 | R:R:S188 | 5.75 | 0 | Yes | No | 3 | 3 | 1 | 2 | R:R:E186 | R:R:T189 | 18.34 | 0 | Yes | No | 3 | 1 | 1 | 2 | R:R:E186 | R:R:T296 | 8.47 | 0 | Yes | No | 3 | 3 | 1 | 2 | L:L:?1 | R:R:E186 | 7.9 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | L:L:?1 | R:R:F193 | 5.18 | 1 | Yes | No | 0 | 1 | 0 | 1 | L:L:Q2 | R:R:S195 | 10.11 | 0 | Yes | No | 0 | 4 | 1 | 2 | L:L:W3 | R:R:F301 | 16.04 | 1 | No | Yes | 0 | 4 | 1 | 2 | L:L:?1 | L:L:Q2 | 5.67 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?1 | L:L:W3 | 6.79 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?1 | L:L:A4 | 4.02 | 1 | Yes | No | 0 | 0 | 0 | 1 | R:R:D104 | R:R:R105 | 2.38 | 1 | No | No | 4 | 4 | 1 | 2 | R:R:E186 | R:R:E187 | 1.27 | 0 | Yes | No | 3 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.50 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 18.00 | Average Links Mediated by Hubs In Shell | 16.00 |
| ![](/psngpcr/ligands/DPN/DPN_7W40_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7W40_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XAU | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Gi1/Beta1/Gamma2 | 2.97 | 2022-08-31 | 10.1038/s41421-022-00405-2 |
![](/psngpcr/ligands/DPN/DPN_7XAU_L_L_1.png)
A 2D representation of the interactions of DPN in 7XAU colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:N186 | R:R:Q187 | 23.77 | 0 | No | No | 1 | 2 | 2 | 1 | R:R:Q187 | R:R:W188 | 7.67 | 0 | No | No | 2 | 2 | 1 | 2 | L:L:?1 | R:R:Q187 | 3.4 | 1 | Yes | No | 0 | 2 | 0 | 1 | L:L:?1 | R:R:I284 | 4.86 | 1 | Yes | No | 0 | 1 | 0 | 1 | R:R:P286 | R:R:S285 | 3.56 | 0 | No | No | 2 | 2 | 1 | 2 | L:L:?1 | R:R:P286 | 8.39 | 1 | Yes | No | 0 | 2 | 0 | 1 | R:R:L290 | R:R:T287 | 8.84 | 0 | No | No | 4 | 1 | 1 | 2 | R:R:L290 | R:R:M293 | 7.07 | 0 | No | No | 4 | 4 | 1 | 2 | L:L:C2 | R:R:F294 | 13.97 | 1 | No | Yes | 0 | 4 | 1 | 2 | L:L:C7 | R:R:F294 | 5.59 | 1 | No | Yes | 0 | 4 | 1 | 2 | L:L:?1 | L:L:C2 | 12.16 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?1 | L:L:C7 | 5.4 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:C2 | L:L:C7 | 7.28 | 1 | No | No | 0 | 0 | 1 | 1 | L:L:?1 | R:R:S279 | 2.56 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:L290 | 2.36 | 1 | Yes | No | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 5.59 | Average Nodes In Shell | 14.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 15.00 | Average Links Mediated by Hubs In Shell | 9.00 |
| ![](/psngpcr/ligands/DPN/DPN_7XAU_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7XAU_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y24 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Go/Beta1/Gamma2 | 3.25 | 2022-10-19 | 10.1038/s41589-022-01130-3 |
![](/psngpcr/ligands/DPN/DPN_7Y24_L_L_1.png)
A 2D representation of the interactions of DPN in 7Y24 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?1 | L:L:C2 | 4.05 | 1 | No | Yes | 0 | 0 | 0 | 1 | L:L:?1 | L:L:C7 | 6.75 | 1 | No | No | 0 | 0 | 0 | 1 | L:L:?1 | L:L:T8 | 6.27 | 1 | No | No | 0 | 0 | 0 | 1 | L:L:C2 | L:L:C7 | 7.28 | 1 | Yes | No | 0 | 0 | 1 | 1 | L:L:C2 | R:R:F294 | 12.57 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:C7 | R:R:K291 | 6.47 | 1 | No | No | 0 | 3 | 1 | 2 | L:L:T8 | R:R:N186 | 4.39 | 0 | No | Yes | 0 | 1 | 1 | 2 | L:L:T8 | R:R:Q187 | 5.67 | 0 | No | No | 0 | 2 | 1 | 2 | L:L:C2 | R:R:S279 | 1.72 | 1 | Yes | No | 0 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 5.69 | Average Nodes In Shell | 9.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 9.00 | Average Links Mediated by Hubs In Shell | 5.00 |
| ![](/psngpcr/ligands/DPN/DPN_7Y24_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7Y24_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y26 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.3 | 2022-10-19 | 10.1038/s41589-022-01130-3 |
![](/psngpcr/ligands/DPN/DPN_7Y26_L_L_1.png)
A 2D representation of the interactions of DPN in 7Y26 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?1 | L:L:C2 | 6.75 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?1 | L:L:T8 | 5.02 | 0 | No | Yes | 0 | 0 | 0 | 1 | L:L:C2 | L:L:C7 | 7.28 | 1 | No | Yes | 0 | 0 | 1 | 2 | L:L:C2 | R:R:F294 | 9.78 | 1 | No | Yes | 0 | 4 | 1 | 2 | L:L:C7 | L:L:T8 | 1.69 | 1 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:C7 | R:R:K291 | 6.47 | 1 | Yes | No | 0 | 3 | 2 | 2 | L:L:C7 | R:R:F294 | 5.59 | 1 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:T8 | R:R:R184 | 9.06 | 1 | Yes | Yes | 0 | 2 | 1 | 2 | L:L:T8 | R:R:N186 | 4.39 | 1 | Yes | No | 0 | 1 | 1 | 2 | L:L:T8 | R:R:Q187 | 8.5 | 1 | Yes | No | 0 | 2 | 1 | 2 | L:L:T8 | R:R:K291 | 3 | 1 | Yes | No | 0 | 3 | 1 | 2 | R:R:N186 | R:R:R184 | 12.05 | 1 | No | Yes | 1 | 2 | 2 | 2 | L:L:?1 | R:R:S279 | 1.28 | 0 | No | No | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 4.35 | Average Nodes In Shell | 10.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 13.00 | Average Links Mediated by Hubs In Shell | 11.00 |
| ![](/psngpcr/ligands/DPN/DPN_7Y26_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7Y26_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y27 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.48 | 2022-10-19 | 10.1038/s41589-022-01130-3 |
![](/psngpcr/ligands/DPN/DPN_7Y27_L_L_1.png)
A 2D representation of the interactions of DPN in 7Y27 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?1 | L:L:C2 | 6.75 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?1 | L:L:T8 | 5.02 | 0 | No | Yes | 0 | 0 | 0 | 1 | L:L:C2 | L:L:C7 | 7.28 | 1 | No | Yes | 0 | 0 | 1 | 2 | L:L:C2 | R:R:F294 | 9.78 | 1 | No | Yes | 0 | 4 | 1 | 2 | L:L:C7 | L:L:T8 | 1.69 | 1 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:C7 | R:R:K291 | 6.47 | 1 | Yes | No | 0 | 3 | 2 | 2 | L:L:C7 | R:R:F294 | 5.59 | 1 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:T8 | R:R:R184 | 9.06 | 1 | Yes | Yes | 0 | 2 | 1 | 2 | L:L:T8 | R:R:N186 | 4.39 | 1 | Yes | No | 0 | 1 | 1 | 2 | L:L:T8 | R:R:Q187 | 8.5 | 1 | Yes | No | 0 | 2 | 1 | 2 | L:L:T8 | R:R:K291 | 3 | 1 | Yes | No | 0 | 3 | 1 | 2 | R:R:N186 | R:R:R184 | 12.05 | 1 | No | Yes | 1 | 2 | 2 | 2 | L:L:?1 | R:R:S279 | 1.28 | 0 | No | No | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 4.35 | Average Nodes In Shell | 10.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 13.00 | Average Links Mediated by Hubs In Shell | 11.00 |
| ![](/psngpcr/ligands/DPN/DPN_7Y27_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7Y27_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7YAE | A | Peptide | Somatostatin | SST2 | Homo Sapiens | Octreotide | - | Gi1/Beta1/Gamma2 | 3.37 | 2023-04-19 | 10.1038/s41467-023-36673-z |
![](/psngpcr/ligands/DPN/DPN_7YAE_L_L_1.png)
A 2D representation of the interactions of DPN in 7YAE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?8 | R:R:T194 | 7.65 | 19 | Yes | No | 0 | 4 | 1 | 2 | R:R:I284 | R:R:L290 | 4.28 | 0 | No | No | 1 | 4 | 1 | 2 | R:R:P286 | R:R:S285 | 5.34 | 0 | No | No | 2 | 2 | 1 | 2 | L:L:?1 | R:R:P286 | 5.59 | 19 | Yes | No | 0 | 2 | 0 | 1 | L:L:C7 | R:R:F294 | 2.79 | 19 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?1 | L:L:C2 | 10.81 | 19 | Yes | No | 0 | 0 | 0 | 1 | L:L:?1 | L:L:C7 | 13.51 | 19 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?1 | L:L:?8 | 16.81 | 19 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:C2 | L:L:C7 | 7.28 | 19 | No | Yes | 0 | 0 | 1 | 1 | L:L:?8 | L:L:C7 | 4.12 | 19 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?1 | R:R:I284 | 2.43 | 19 | Yes | No | 0 | 1 | 0 | 1 | L:L:?8 | R:R:S192 | 1.95 | 19 | Yes | No | 0 | 4 | 1 | 2 | L:L:C2 | R:R:S279 | 1.72 | 19 | No | No | 0 | 4 | 1 | 2 | L:L:C7 | R:R:K291 | 1.62 | 19 | Yes | No | 0 | 3 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 9.83 | Average Nodes In Shell | 13.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 14.00 | Average Links Mediated by Hubs In Shell | 11.00 |
| ![](/psngpcr/ligands/DPN/DPN_7YAE_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_7YAE_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8FEG | A | Peptide | Opioid | KOP | Homo Sapiens | PRD_002517 | - | Gi1/Beta1/Gamma2 | 2.54 | 2023-12-06 | 10.1038/s41467-023-43718-w |
![](/psngpcr/ligands/DPN/DPN_8FEG_L_L_9.png)
A 2D representation of the interactions of DPN in 8FEG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:Q115 | R:R:Y66 | 6.76 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | R:R:Y119 | R:R:Y66 | 5.96 | 1 | Yes | Yes | 4 | 6 | 2 | 2 | R:R:Y320 | R:R:Y66 | 6.95 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:Q115 | R:R:Y119 | 16.91 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:Q115 | R:R:Y320 | 5.64 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | L:L:?9 | R:R:Q115 | 7.93 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:V118 | R:R:Y119 | 3.79 | 0 | No | Yes | 5 | 4 | 2 | 2 | L:L:T8 | R:R:V118 | 7.93 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:I316 | R:R:Y119 | 8.46 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | R:R:C131 | R:R:W124 | 6.53 | 1 | No | Yes | 9 | 8 | 2 | 2 | R:R:V134 | R:R:W124 | 3.68 | 0 | No | Yes | 6 | 8 | 1 | 2 | R:R:C210 | R:R:W124 | 20.89 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | L:L:T8 | R:R:W124 | 3.64 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | R:R:C131 | R:R:C210 | 7.28 | 1 | No | Yes | 9 | 9 | 2 | 1 | L:L:?9 | R:R:V134 | 5.07 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?9 | R:R:L135 | 4.71 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?10 | R:R:D138 | 13.51 | 1 | Yes | No | 0 | 6 | 1 | 2 | L:L:?10 | R:R:M142 | 8.21 | 1 | Yes | No | 0 | 7 | 1 | 2 | L:L:T8 | R:R:C210 | 5.07 | 1 | Yes | Yes | 0 | 9 | 1 | 1 | L:L:?9 | R:R:C210 | 5.4 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:I294 | R:R:K227 | 4.36 | 1 | No | Yes | 5 | 4 | 2 | 2 | L:L:?10 | R:R:K227 | 4.68 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?10 | R:R:V230 | 4.94 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:I290 | R:R:I316 | 4.42 | 1 | No | Yes | 6 | 5 | 2 | 2 | L:L:?10 | R:R:I290 | 8.29 | 1 | Yes | No | 0 | 6 | 1 | 2 | L:L:?10 | R:R:I294 | 20.13 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:I316 | R:R:Y312 | 7.25 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | L:L:?10 | R:R:Y312 | 3.89 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | R:R:I316 | R:R:Y320 | 4.84 | 1 | Yes | Yes | 5 | 6 | 2 | 2 | L:L:?10 | R:R:I316 | 7.1 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?10 | R:R:Y320 | 10.7 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?9 | L:L:T8 | 10.04 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?10 | L:L:?9 | 18.57 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?10 | R:R:G319 | 2.84 | 1 | Yes | No | 0 | 7 | 1 | 2 | R:R:G197 | R:R:L135 | 1.71 | 0 | No | No | 4 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 8.62 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 35.00 | Average Links Mediated by Hubs In Shell | 34.00 |
| ![](/psngpcr/ligands/DPN/DPN_8FEG_L_L_9_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/DPN/DPN_8FEG_L_L_9_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|