psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C2	L:L:C7	7.28	No	No	0	0	0
2	L:L:C2	R:R:F294	8.38	No	Yes	0	0	4
3	L:L:Y3	R:R:Y205	24.82	Yes	No	0	0	4
4	L:L:Y3	R:R:F208	9.28	Yes	Yes	0	0	7
5	L:L:Y3	R:R:I209	6.04	Yes	Yes	0	0	5
6	L:L:?4	L:L:K5	19.03	Yes	Yes	1	0	0
7	L:L:?4	R:R:Q126	4.23	Yes	Yes	1	0	7
8	L:L:?4	R:R:F127	4.83	Yes	Yes	1	0	6
9	L:L:?4	R:R:F208	13.53	Yes	Yes	1	0	7
10	L:L:?4	R:R:T212	14.04	Yes	Yes	1	0	4
11	L:L:?4	R:R:F272	5.8	Yes	Yes	1	0	6
12	L:L:?4	R:R:N276	5.45	Yes	No	0	0	6
13	L:L:K5	R:R:Q126	4.07	Yes	Yes	1	0	7
14	L:L:K5	R:R:F272	3.72	Yes	Yes	1	0	6
15	L:L:K5	R:R:V298	4.55	Yes	Yes	1	0	6
16	L:L:K5	R:R:Y302	5.97	Yes	Yes	1	0	7
17	L:L:V6	R:R:T194	4.76	No	No	0	0	4
18	R:R:N43	R:R:T47	4.39	No	No	0	3	5
19	R:R:G292	R:R:L46	3.42	No	No	0	1	5
20	R:R:F296	R:R:L46	8.53	No	No	0	5	5
21	R:R:T47	R:R:V103	4.76	No	No	0	5	4
22	R:R:A104	R:R:T47	5.03	No	No	0	5	5
23	R:R:F48	R:R:V52	7.87	No	No	0	6	5
24	R:R:F296	R:R:I49	13.82	No	No	0	5	5
25	R:R:L96	R:R:Y50	4.69	Yes	Yes	0	7	7
26	R:R:V298	R:R:Y50	5.05	Yes	Yes	0	6	7
27	R:R:V299	R:R:Y50	21.45	No	Yes	0	5	7
28	R:R:I56	R:R:V53	3.07	Yes	No	0	4	7
29	R:R:C54	R:R:M93	4.86	No	Yes	1	6	6
30	R:R:C54	R:R:L96	6.35	No	Yes	1	6	7
31	R:R:I55	R:R:I56	4.42	No	Yes	0	4	4
32	R:R:C306	R:R:I56	6.55	No	Yes	0	8	4
33	R:R:G57	R:R:M93	3.49	No	Yes	0	8	6
34	R:R:L58	R:R:M93	8.48	No	Yes	0	6	6
35	R:R:L58	R:R:L94	5.54	No	No	0	6	5
36	R:R:G60	R:R:P309	4.06	No	No	0	8	9
37	R:R:A86	R:R:N61	4.69	No	Yes	0	9	9
38	R:R:D89	R:R:N61	17.5	No	Yes	0	9	9
39	R:R:E90	R:R:N61	9.2	No	Yes	0	7	9
40	R:R:N61	R:R:P309	14.66	Yes	No	0	9	9
41	R:R:E90	R:R:T62	8.47	No	No	0	7	5
42	R:R:F323	R:R:L63	7.31	No	No	0	6	6
43	R:R:A86	R:R:V64	3.39	No	No	0	9	9
44	R:R:A313	R:R:V64	3.39	No	No	4	7	9
45	R:R:F319	R:R:V64	5.24	Yes	No	4	8	9
46	R:R:I65	R:R:L69	5.71	No	No	5	7	3
47	R:R:I65	R:R:L83	4.28	No	Yes	5	7	6
48	R:R:A86	R:R:I65	3.25	No	No	0	9	7
49	R:R:F319	R:R:V67	10.49	Yes	No	0	8	7
50	R:R:F323	R:R:V67	5.24	No	No	0	6	7
51	R:R:I68	R:R:L83	9.99	No	Yes	0	7	6
52	R:R:F319	R:R:I68	5.02	Yes	No	0	8	7
53	R:R:L69	R:R:L83	4.15	No	Yes	5	3	6
54	R:R:R70	R:R:Y71	3.09	No	No	0	4	6
55	R:R:V326	R:R:Y71	15.14	No	No	0	5	6
56	R:R:K73	R:R:T76	16.52	No	No	3	5	7
57	R:R:K73	R:R:N79	13.99	No	Yes	3	5	8
58	R:R:K73	R:R:N318	6.99	No	No	3	5	5
59	R:R:K75	R:R:P156	18.4	No	No	0	7	3
60	R:R:N79	R:R:T76	7.31	Yes	No	3	8	7
61	R:R:I77	R:R:Y81	3.63	No	Yes	6	4	7
62	R:R:I77	R:R:P156	5.08	No	No	0	4	3
63	R:R:A159	R:R:I77	3.25	No	No	6	7	4
64	R:R:N79	R:R:T78	4.39	Yes	No	0	8	8
65	R:R:N318	R:R:N79	4.09	No	Yes	3	5	8
66	R:R:A159	R:R:I80	3.25	No	No	0	7	5
67	R:R:I80	R:R:T163	3.04	No	Yes	0	5	7
68	R:R:M136	R:R:Y81	7.18	Yes	Yes	0	9	7
69	R:R:D139	R:R:Y81	9.2	No	Yes	0	8	7
70	R:R:A159	R:R:Y81	4	No	Yes	6	7	7
71	R:R:I162	R:R:Y81	3.63	No	Yes	0	5	7
72	R:R:T163	R:R:Y81	4.99	Yes	Yes	0	7	7
73	R:R:I82	R:R:M136	5.83	No	Yes	0	8	9
74	R:R:A313	R:R:I82	3.25	No	No	0	7	8
75	R:R:I87	R:R:L83	4.28	No	Yes	0	7	6
76	R:R:C132	R:R:N84	6.3	No	No	0	8	9
77	R:R:N84	R:R:T163	10.24	No	Yes	0	9	7
78	R:R:N84	R:R:W167	11.3	No	Yes	0	9	9
79	R:R:C132	R:R:L85	3.17	No	Yes	0	8	9
80	R:R:L133	R:R:L85	4.15	No	Yes	1	9	9
81	R:R:L85	R:R:M136	4.24	Yes	Yes	0	9	9
82	R:R:L85	R:R:N308	10.98	Yes	Yes	1	9	9
83	R:R:I87	R:R:W167	3.52	No	Yes	0	7	9
84	R:R:A88	R:R:T128	3.36	No	No	0	8	7
85	R:R:D89	R:R:S305	10.31	No	No	0	9	8
86	R:R:D89	R:R:N308	5.39	No	Yes	0	9	9
87	R:R:L91	R:R:L94	5.54	No	No	0	7	5
88	R:R:L91	R:R:N125	13.73	No	Yes	0	7	7
89	R:R:D122	R:R:F92	15.52	No	Yes	1	6	6
90	R:R:F92	R:R:N125	3.62	Yes	Yes	0	6	7
91	R:R:F92	R:R:Q126	14.05	Yes	Yes	1	6	7
92	R:R:F92	R:R:Y302	22.69	Yes	Yes	1	6	7
93	R:R:L96	R:R:M93	5.65	Yes	Yes	1	7	6
94	R:R:D122	R:R:G95	5.03	No	No	0	6	6
95	R:R:L96	R:R:Y302	16.41	Yes	Yes	1	7	7
96	R:R:F98	R:R:W108	17.04	No	Yes	2	5	8
97	R:R:F98	R:R:I114	7.54	No	No	2	5	6
98	R:R:F98	R:R:V118	9.18	No	No	0	5	5
99	R:R:Q102	R:R:W108	18.62	Yes	Yes	2	5	8
100	R:R:Q102	R:R:S192	4.33	Yes	No	0	5	4
101	R:R:C193	R:R:Q102	4.58	No	Yes	2	9	5
102	R:R:D295	R:R:V103	4.38	No	No	0	2	4
103	R:R:H107	R:R:L105	11.57	No	No	0	4	5
104	R:R:R190	R:R:V106	9.15	No	No	0	1	4
105	R:R:H107	R:R:R190	10.16	No	No	0	4	1
106	R:R:P109	R:R:W108	36.48	No	Yes	0	4	8
107	R:R:I114	R:R:W108	15.27	No	Yes	2	6	8
108	R:R:C115	R:R:W108	15.67	No	Yes	2	9	8
109	R:R:C193	R:R:W108	5.22	No	Yes	2	9	8
110	R:R:F110	R:R:K112	4.96	No	No	0	6	3
111	R:R:G111	R:R:L183	5.13	No	No	0	7	4
112	R:R:A113	R:R:K112	4.82	No	No	0	1	3
113	R:R:C115	R:R:C193	7.28	No	No	2	9	9
114	R:R:A181	R:R:R116	6.91	No	No	0	4	6
115	R:R:T120	R:R:V117	4.76	No	No	0	6	5
116	R:R:I174	R:R:T120	4.56	No	No	0	7	6
117	R:R:N125	R:R:V121	4.43	Yes	No	0	7	5
118	R:R:D122	R:R:Y302	9.2	No	Yes	1	6	7
119	R:R:G123	R:R:I174	3.53	No	No	0	4	7
120	R:R:I124	R:R:N125	7.08	No	Yes	0	5	7
121	R:R:I124	R:R:S170	4.64	No	No	0	5	7
122	R:R:N125	R:R:W167	6.78	Yes	Yes	0	7	9
123	R:R:F127	R:R:Q126	7.03	Yes	Yes	1	6	7
124	R:R:Q126	R:R:W269	7.67	Yes	Yes	1	7	8
125	R:R:F127	R:R:V173	3.93	Yes	No	0	6	4
126	R:R:F127	R:R:T212	3.89	Yes	Yes	1	6	4
127	R:R:F127	R:R:G216	3.01	Yes	No	0	6	6
128	R:R:T128	R:R:W167	12.13	No	Yes	0	7	9
129	R:R:S170	R:R:T128	3.2	No	No	0	7	7
130	R:R:S129	R:R:S305	3.26	No	No	0	9	8
131	R:R:I130	R:R:W269	4.7	No	Yes	0	8	8
132	R:R:F131	R:R:T134	3.89	No	Yes	7	6	7
133	R:R:F131	R:R:P220	4.33	No	No	7	6	9
134	R:R:L133	R:R:N308	4.12	No	Yes	1	9	9
135	R:R:L133	R:R:Y312	5.86	No	Yes	1	9	9
136	R:R:P220	R:R:T134	3.5	No	Yes	7	9	7
137	R:R:I223	R:R:T134	4.56	No	Yes	0	6	7
138	R:R:I224	R:R:T134	6.08	No	Yes	0	7	7
139	R:R:M136	R:R:Y312	4.79	Yes	Yes	0	9	9
140	R:R:I224	R:R:S137	6.19	No	No	0	7	9
141	R:R:S137	R:R:Y228	11.45	No	Yes	0	9	9
142	R:R:D139	R:R:R154	10.72	No	No	0	8	5
143	R:R:R140	R:R:Y228	9.26	No	Yes	1	9	9
144	R:R:R140	R:R:Y312	8.23	No	Yes	1	9	9
145	R:R:V145	R:R:Y141	12.62	No	Yes	8	7	8
146	R:R:H146	R:R:Y141	7.62	No	Yes	8	5	8
147	R:R:C227	R:R:Y141	8.06	No	Yes	0	7	8
148	R:R:F230	R:R:Y141	8.25	No	Yes	0	4	8
149	R:R:L142	R:R:S150	4.5	No	No	0	4	5
150	R:R:A143	R:R:R154	5.53	No	No	0	8	5
151	R:R:I231	R:R:V144	9.22	No	No	0	9	8
152	R:R:H146	R:R:V145	9.69	No	No	8	5	7
153	R:R:K234	R:R:V145	4.55	No	No	0	5	7
154	R:R:K152	R:R:W153	8.12	No	No	0	4	3
155	R:R:R155	R:R:R157	4.26	No	No	0	6	4
156	R:R:R155	R:R:T158	3.88	No	No	0	6	5
157	R:R:G168	R:R:L171	3.42	No	No	0	4	3
158	R:R:V173	R:R:Y211	7.57	No	No	0	4	4
159	R:R:I174	R:R:I177	4.42	No	No	0	7	3
160	R:R:L175	R:R:M178	4.24	No	No	0	4	5
161	R:R:F208	R:R:I177	5.02	Yes	No	0	7	3
162	R:R:I179	R:R:Y180	13.3	No	No	0	4	4
163	R:R:W197	R:R:Y180	12.54	Yes	No	9	5	4
164	R:R:P198	R:R:Y180	11.13	No	No	9	5	4
165	R:R:G182	R:R:N196	5.09	No	No	0	5	3
166	R:R:N196	R:R:R184	9.64	No	No	0	3	2
167	R:R:S185	R:R:S191	6.52	No	No	0	2	5
168	R:R:N186	R:R:Q187	5.28	No	No	0	1	2
169	R:R:Q187	R:R:W188	7.67	No	No	0	2	2
170	R:R:I195	R:R:T194	3.04	No	No	0	5	4
171	R:R:I195	R:R:Y205	6.04	No	No	0	5	4
172	R:R:P198	R:R:W197	16.21	No	Yes	9	5	5
173	R:R:T206	R:R:V280	3.17	No	No	0	3	4
174	R:R:G207	R:R:I210	3.53	No	No	0	4	5
175	R:R:F208	R:R:T212	3.89	Yes	Yes	1	7	4
176	R:R:I209	R:R:N276	7.08	Yes	No	0	5	6
177	R:R:I209	R:R:V277	3.07	Yes	No	0	5	5
178	R:R:I209	R:R:V280	3.07	Yes	No	0	5	4
179	R:R:L215	R:R:Y211	3.52	No	No	0	4	4
180	R:R:T212	R:R:Y273	6.24	Yes	Yes	1	4	7
181	R:R:F213	R:R:F217	15	No	Yes	1	5	8
182	R:R:F213	R:R:L218	6.09	No	No	1	5	4
183	R:R:F213	R:R:Y273	20.63	No	Yes	1	5	7
184	R:R:F217	R:R:L218	4.87	Yes	No	1	8	4
185	R:R:F217	R:R:L221	3.65	Yes	Yes	1	8	6
186	R:R:F217	R:R:F265	5.36	Yes	Yes	1	8	9
187	R:R:F217	R:R:I266	3.77	Yes	No	1	8	6
188	R:R:F217	R:R:W269	3.01	Yes	Yes	1	8	8
189	R:R:F217	R:R:L270	3.65	Yes	Yes	1	8	5
190	R:R:F217	R:R:Y273	3.09	Yes	Yes	1	8	7
191	R:R:P220	R:R:V219	3.53	No	No	0	9	5
192	R:R:C225	R:R:L221	3.17	No	Yes	0	5	6
193	R:R:F265	R:R:L221	7.31	Yes	Yes	1	9	6
194	R:R:I266	R:R:L221	4.28	No	Yes	1	6	6
195	R:R:C225	R:R:V262	3.42	No	No	0	5	7
196	R:R:V258	R:R:Y228	8.83	No	Yes	0	8	9
197	R:R:V261	R:R:Y228	3.79	No	Yes	0	8	9
198	R:R:Y228	R:R:Y312	4.96	Yes	Yes	1	9	9
199	R:R:F230	R:R:L229	3.65	No	No	0	4	4
200	R:R:F230	R:R:I233	6.28	No	No	0	4	3
201	R:R:I232	R:R:T255	3.04	No	No	0	5	7
202	R:R:V235	R:R:V254	6.41	No	No	0	8	8
203	R:R:E251	R:R:K236	22.95	Yes	No	0	6	4
204	R:R:I240	R:R:S237	3.1	No	No	0	3	5
205	R:R:G239	R:R:S244	3.71	No	No	0	5	3
206	R:R:G243	R:R:S244	3.71	No	No	0	1	3
207	R:R:K253	R:R:M257	4.32	No	No	0	7	8
208	R:R:L315	R:R:M257	11.31	No	No	0	6	8
209	R:R:I260	R:R:L311	4.28	No	Yes	0	6	8
210	R:R:L311	R:R:V261	7.45	Yes	No	0	8	8
211	R:R:L311	R:R:V264	4.47	Yes	No	0	8	7
212	R:R:F265	R:R:W269	6.01	Yes	Yes	1	9	8
213	R:R:F265	R:R:N304	4.83	Yes	Yes	1	9	9
214	R:R:I266	R:R:L270	4.28	No	Yes	1	6	5
215	R:R:C268	R:R:N304	4.72	No	Yes	0	8	9
216	R:R:W269	R:R:Y273	4.82	Yes	Yes	1	8	7
217	R:R:T301	R:R:W269	12.13	No	Yes	0	7	8
218	R:R:N304	R:R:W269	7.91	Yes	Yes	1	9	8
219	R:R:L270	R:R:P271	8.21	Yes	No	0	5	9
220	R:R:I274	R:R:L270	5.71	No	Yes	0	5	5
221	R:R:P271	R:R:V297	3.53	No	No	0	9	7
222	R:R:F272	R:R:Y273	8.25	Yes	Yes	1	6	7
223	R:R:F272	R:R:V298	3.93	Yes	Yes	1	6	6
224	R:R:F272	R:R:T301	6.49	Yes	No	0	6	7
225	R:R:F275	R:R:F294	3.22	No	Yes	0	4	4
226	R:R:F275	R:R:V297	9.18	No	No	0	4	7
227	R:R:F294	R:R:N276	4.83	Yes	No	0	4	6
228	R:R:P288	R:R:T287	5.25	No	Yes	0	3	1
229	R:R:L290	R:R:T287	5.9	No	Yes	0	4	1
230	R:R:F294	R:R:V298	5.24	Yes	Yes	0	4	6
231	R:R:T301	R:R:Y302	3.75	No	Yes	0	7	7
232	R:R:N304	R:R:N308	8.17	Yes	Yes	1	9	9
233	R:R:A313	R:R:F319	5.55	No	Yes	4	7	8
234	R:R:F314	R:R:K320	7.44	No	No	0	7	8
235	R:R:N318	R:R:S316	5.96	No	No	0	5	8
236	R:R:D317	R:R:K320	6.91	No	No	0	5	8
237	R:R:K160	R:R:T163	3	No	Yes	0	1	7
238	R:R:I138	R:R:I223	2.94	No	No	0	6	6
239	R:R:I240	R:R:K248	2.91	No	No	0	3	3
240	R:R:D139	R:R:T78	2.89	No	No	0	8	8
241	R:R:P156	R:R:R155	2.88	No	No	0	3	6
242	R:R:K249	R:R:K252	2.87	No	No	0	4	5
243	R:R:I138	R:R:L142	2.85	No	No	0	6	4
244	R:R:I214	R:R:L218	2.85	No	No	0	4	4
245	R:R:L105	R:R:M101	2.83	No	No	0	5	5
246	R:R:L171	R:R:L172	2.77	No	No	0	3	3
247	R:R:L172	R:R:L175	2.77	No	No	0	3	4
248	R:R:L46	R:R:N43	2.75	No	No	0	5	3
249	R:R:P176	R:R:W197	2.7	No	Yes	0	8	5
250	R:R:E251	R:R:K248	2.7	Yes	No	0	6	3
251	R:R:A100	R:R:Y50	2.67	No	Yes	0	6	7
252	R:R:L99	R:R:Q102	2.66	No	Yes	0	6	5
253	R:R:F131	R:R:V169	2.62	No	No	0	6	4
254	R:R:F296	R:R:V299	2.62	No	No	0	5	5
255	R:R:V135	R:R:Y81	2.52	No	Yes	0	7	7
256	R:R:F275	R:R:M293	2.49	No	No	0	4	4
257	R:R:K249	R:R:R247	2.48	No	No	0	4	4
258	R:R:I231	R:R:Y228	2.42	No	Yes	0	9	9
259	R:R:N186	R:R:R184	2.41	No	No	0	1	2
260	R:R:F314	R:R:F323	2.14	No	No	0	7	6
261	R:R:C59	R:R:G60	1.96	No	No	0	5	8
262	R:R:C115	R:R:G111	1.96	No	No	0	9	7
263	R:R:W197	R:R:Y205	1.93	Yes	No	0	5	4
264	R:R:C54	R:R:P97	1.88	No	No	0	6	8
265	R:R:G189	R:R:S185	1.86	No	No	0	6	2
266	R:R:G239	R:R:S238	1.86	No	No	0	5	5
267	R:R:G95	R:R:V118	1.84	No	No	0	6	5
268	R:R:G243	R:R:V242	1.84	No	No	0	1	3
269	R:R:G207	R:R:T206	1.82	No	No	0	4	3
270	R:R:P286	R:R:S285	1.78	No	No	0	2	2
271	R:R:G57	R:R:I56	1.76	No	Yes	0	8	4
272	R:R:C227	R:R:S137	1.72	No	No	0	7	9
273	R:R:C132	R:R:V166	1.71	No	No	0	8	6
274	R:R:A44	R:R:V45	1.7	No	No	0	4	5
275	R:R:A307	R:R:V264	1.7	No	No	0	6	7
276	R:R:A289	R:R:T287	1.68	No	Yes	0	1	1
277	R:R:L175	R:R:P176	1.64	No	No	0	4	8
278	R:R:S322	R:R:V67	1.62	No	No	0	5	7
279	R:R:A72	R:R:M74	1.61	No	No	0	5	7
280	R:R:A283	R:R:M282	1.61	No	No	0	4	3
281	R:R:S259	R:R:T255	1.6	No	No	0	4	7
282	R:R:S285	R:R:T287	1.6	No	Yes	0	2	1
283	R:R:A104	R:R:L105	1.58	No	No	0	5	5
284	R:R:I231	R:R:V254	1.54	No	No	0	9	8
285	R:R:I232	R:R:V254	1.54	No	No	0	5	8
286	R:R:I232	R:R:V258	1.54	No	No	0	5	8
287	R:R:H146	R:R:P147	1.53	No	No	0	5	8
288	R:R:M161	R:R:T158	1.51	No	No	0	1	5
289	R:R:G189	R:R:R190	1.5	No	No	0	6	1
290	R:R:L300	R:R:V297	1.49	No	No	0	7	7
291	R:R:N325	R:R:V326	1.48	No	No	0	4	5
292	R:R:L226	R:R:T222	1.47	No	No	0	5	4
293	R:R:I177	R:R:M119	1.46	No	No	0	3	5
294	R:R:K75	R:R:M74	1.44	No	No	0	7	7
295	R:R:E251	R:R:V235	1.43	Yes	No	0	6	8
296	R:R:I284	R:R:L290	1.43	No	No	0	1	4
297	R:R:D295	R:R:K291	1.38	No	No	0	2	3
298	R:R:L311	R:R:L315	1.38	Yes	No	0	8	6
299	R:R:K320	R:R:Q324	1.36	No	No	0	8	4
300	R:R:E251	R:R:K252	1.35	Yes	No	0	6	5
301	R:R:R184	R:R:S185	1.32	No	No	0	2	2
302	R:R:R241	R:R:S237	1.32	No	No	0	1	5
303	L:L:Y3	R:R:S279	1.27	Yes	No	0	0	4
304	R:R:S322	R:R:Y71	1.27	No	No	0	5	6
305	R:R:F110	R:R:I114	1.26	No	No	0	6	6
306	R:R:T206	R:R:W204	1.21	No	No	0	3	3
307	R:R:F48	R:R:F51	1.07	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y3	10.3525	4	0	0
2	L:L:?4	9.55857	7	1	0
3	L:L:K5	7.468	5	1	0
4	R:R:Y50	8.465	4	0	7
5	R:R:I56	3.95	4	0	4
6	R:R:N61	11.5125	4	0	9
7	R:R:N79	7.445	4	3	8
8	R:R:Y81	5.02143	7	6	7
9	R:R:L83	5.675	4	5	6
10	R:R:L85	5.635	4	1	9
11	R:R:F92	13.97	4	1	6
12	R:R:M93	5.62	4	1	6
13	R:R:L96	8.275	4	1	7
14	R:R:Q102	7.5475	4	2	5
15	R:R:W108	18.05	6	2	8
16	R:R:N125	7.128	5	0	7
17	R:R:Q126	7.41	5	1	7
18	R:R:F127	4.538	5	1	6
19	R:R:T134	4.5075	4	7	7
20	R:R:M136	5.51	4	0	9
21	R:R:Y141	9.1375	4	8	8
22	R:R:T163	5.3175	4	0	7
23	R:R:W167	8.4325	4	0	9
24	R:R:W197	8.345	4	9	5
25	R:R:F208	7.93	4	1	7
26	R:R:I209	4.815	4	0	5
27	R:R:T212	7.015	4	1	4
28	R:R:F217	5.3	8	1	8
29	R:R:L221	4.6025	4	1	6
30	R:R:Y228	6.785	6	1	9
31	R:R:E251	7.1075	4	0	6
32	R:R:F265	5.8775	4	1	9
33	R:R:W269	6.60714	7	1	8
34	R:R:L270	5.4625	4	1	5
35	R:R:F272	5.638	5	1	6
36	R:R:Y273	8.606	5	1	7
37	R:R:T287	3.6075	4	0	1
38	R:R:F294	5.4175	4	0	4
39	R:R:V298	4.6925	4	1	6
40	R:R:Y302	11.604	5	1	7
41	R:R:N304	6.4075	4	1	9
42	R:R:N308	7.165	4	1	9
43	R:R:L311	4.395	4	0	8
44	R:R:Y312	5.96	4	1	9
45	R:R:F319	6.575	4	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I209	R:R:N276	12.0009	7.08	Yes	No	0	5	6
2	L:L:Y3	R:R:Y205	27.0191	24.82	Yes	No	0	0	4
3	L:L:?4	R:R:N276	12.8131	5.45	Yes	No	0	0	6
4	L:L:?4	R:R:F208	27.2096	13.53	Yes	Yes	1	0	7
5	R:R:F294	R:R:V298	14.7414	5.24	Yes	Yes	0	4	6
6	R:R:F272	R:R:V298	28.4483	3.93	Yes	Yes	1	6	6
7	L:L:K5	R:R:V298	19.7096	4.55	Yes	Yes	1	0	6
8	R:R:V298	R:R:Y50	40.8485	5.05	Yes	Yes	0	6	7
9	R:R:V299	R:R:Y50	55.5762	21.45	No	Yes	0	5	7
10	R:R:F296	R:R:V299	53.4619	2.62	No	No	0	5	5
11	R:R:F296	R:R:L46	49.206	8.53	No	No	0	5	5
12	R:R:L46	R:R:N43	44.9138	2.75	No	No	0	5	3
13	R:R:N43	R:R:T47	42.7541	4.39	No	No	0	3	5
14	R:R:A104	R:R:T47	34.0245	5.03	No	No	0	5	5
15	R:R:L96	R:R:Y50	20.667	4.69	Yes	Yes	0	7	7
16	L:L:?4	R:R:Q126	28.5163	4.23	Yes	Yes	1	0	7
17	R:R:Q126	R:R:W269	38.8113	7.67	Yes	Yes	1	7	8
18	R:R:N304	R:R:W269	91.8466	7.91	Yes	Yes	1	9	8
19	R:R:N304	R:R:N308	100	8.17	Yes	Yes	1	9	9
20	R:R:D89	R:R:N308	20.4129	5.39	No	Yes	0	9	9
21	R:R:D89	R:R:N61	15.6624	17.5	No	Yes	0	9	9
22	L:L:K5	R:R:Q126	14.6143	4.07	Yes	Yes	1	0	7
23	R:R:F272	R:R:Y273	14.9773	8.25	Yes	Yes	1	6	7
24	R:R:W269	R:R:Y273	23.5889	4.82	Yes	Yes	1	8	7
25	R:R:F272	R:R:T301	12.4909	6.49	Yes	No	0	6	7
26	R:R:T301	R:R:W269	31.4564	12.13	No	Yes	0	7	8
27	R:R:F92	R:R:Q126	25.2541	14.05	Yes	Yes	1	6	7
28	R:R:F92	R:R:N125	32.3593	3.62	Yes	Yes	0	6	7
29	R:R:N125	R:R:W167	35.7895	6.78	Yes	Yes	0	7	9
30	R:R:I87	R:R:W167	14.206	3.52	No	Yes	0	7	9
31	R:R:I87	R:R:L83	12.7858	4.28	No	Yes	0	7	6
32	R:R:I68	R:R:L83	10.1543	9.99	No	Yes	0	7	6
33	R:R:F319	R:R:V67	16.765	10.49	Yes	No	0	8	7
34	R:R:F92	R:R:Y302	12.6679	22.69	Yes	Yes	1	6	7
35	R:R:L85	R:R:N308	23.294	10.98	Yes	Yes	1	9	9
36	R:R:L85	R:R:M136	24.1016	4.24	Yes	Yes	0	9	9
37	R:R:I82	R:R:M136	12.2505	5.83	No	Yes	0	8	9
38	R:R:A313	R:R:I82	10.4764	3.25	No	No	0	7	8
39	R:R:N84	R:R:W167	25.9256	11.3	No	Yes	0	9	9
40	R:R:N84	R:R:T163	19.6461	10.24	No	Yes	0	9	7
41	R:R:T163	R:R:Y81	17.9673	4.99	Yes	Yes	0	7	7
42	R:R:D139	R:R:Y81	14.3966	9.2	No	Yes	0	8	7
43	R:R:M136	R:R:Y81	25.3403	7.18	Yes	Yes	0	9	7
44	R:R:I77	R:R:Y81	14.5327	3.63	No	Yes	6	4	7
45	R:R:I77	R:R:P156	13.0263	5.08	No	No	0	4	3
46	R:R:L133	R:R:N308	64.0744	4.12	No	Yes	1	9	9
47	R:R:D122	R:R:Y302	13.0082	9.2	No	Yes	1	6	7
48	R:R:D122	R:R:G95	25.8757	5.03	No	No	0	6	6
49	R:R:G95	R:R:V118	24.3103	1.84	No	No	0	6	5
50	R:R:F98	R:R:V118	22.863	9.18	No	No	0	5	5
51	R:R:F98	R:R:W108	14.6915	17.04	No	Yes	2	5	8
52	R:R:A104	R:R:L105	31.8194	1.58	No	No	0	5	5
53	R:R:H107	R:R:L105	27.382	11.57	No	No	0	4	5
54	R:R:H107	R:R:R190	25.1497	10.16	No	No	0	4	1
55	R:R:F208	R:R:I177	10.9664	5.02	Yes	No	0	7	3
56	R:R:L133	R:R:Y312	66.4292	5.86	No	Yes	1	9	9
57	R:R:Y228	R:R:Y312	79.5145	4.96	Yes	Yes	1	9	9
58	R:R:S137	R:R:Y228	37.1642	11.45	No	Yes	0	9	9
59	R:R:I224	R:R:S137	19.0971	6.19	No	No	0	7	9
60	R:R:I224	R:R:T134	17.2278	6.08	No	Yes	0	7	7
61	R:R:C227	R:R:S137	17.1007	1.72	No	No	0	7	9
62	R:R:C227	R:R:Y141	15.2223	8.06	No	Yes	0	7	8
63	R:R:I231	R:R:Y228	24.02	2.42	No	Yes	0	9	9
64	R:R:W197	R:R:Y205	19.6869	1.93	Yes	No	0	5	4
65	R:R:P176	R:R:W197	11.9192	2.7	No	Yes	0	8	5
66	R:R:G189	R:R:R190	20.6579	1.5	No	No	0	6	1
67	R:R:G189	R:R:S185	18.3984	1.86	No	No	0	6	2
68	R:R:R184	R:R:S185	13.8521	1.32	No	No	0	2	2
69	R:R:V261	R:R:Y228	15.2813	3.79	No	Yes	0	8	9
70	R:R:I231	R:R:V254	20.4991	1.54	No	No	0	9	8
71	R:R:V235	R:R:V254	18.9338	6.41	No	No	0	8	8
72	R:R:E251	R:R:V235	17.0735	1.43	Yes	No	0	6	8
73	R:R:L311	R:R:V261	13.4165	7.45	Yes	No	0	8	8
74	L:L:Y3	R:R:F208	28.1352	9.28	Yes	Yes	0	0	7
75	R:R:F208	R:R:T212	12.2777	3.89	Yes	Yes	1	7	4
76	R:R:L96	R:R:Y302	28.0127	16.41	Yes	Yes	1	7	7
77	R:R:T212	R:R:Y273	13.2577	6.24	Yes	Yes	1	4	7
78	R:R:D122	R:R:F92	14.4192	15.52	No	Yes	1	6	6
79	R:R:F217	R:R:W269	10.7123	3.01	Yes	Yes	1	8	8
80	R:R:T301	R:R:Y302	20.118	3.75	No	Yes	0	7	7
81	R:R:M136	R:R:Y312	16.6652	4.79	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C2	R:R:F294	8.38	0	No	Yes	0	4	0	1
L:L:Y3	R:R:Y205	24.82	0	Yes	No	0	4	0	1
L:L:Y3	R:R:F208	9.28	0	Yes	Yes	0	7	0	1
L:L:Y3	R:R:I209	6.04	0	Yes	Yes	0	5	0	1
L:L:?4	R:R:Q126	4.23	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:F127	4.83	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:F208	13.53	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:T212	14.04	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:F272	5.8	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N276	5.45	1	Yes	No	0	6	0	1
L:L:K5	R:R:Q126	4.07	1	Yes	Yes	0	7	0	1
L:L:K5	R:R:F272	3.72	1	Yes	Yes	0	6	0	1
L:L:K5	R:R:V298	4.55	1	Yes	Yes	0	6	0	1
L:L:K5	R:R:Y302	5.97	1	Yes	Yes	0	7	0	1
L:L:V6	R:R:T194	4.76	0	No	No	0	4	0	1
R:R:L96	R:R:Y50	4.69	1	Yes	Yes	7	7	2	2
R:R:V298	R:R:Y50	5.05	1	Yes	Yes	6	7	1	2
R:R:D122	R:R:F92	15.52	1	No	Yes	6	6	2	2
R:R:F92	R:R:Q126	14.05	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	22.69	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	16.41	1	Yes	Yes	7	7	2	1
R:R:D122	R:R:Y302	9.2	1	No	Yes	6	7	2	1
R:R:F127	R:R:Q126	7.03	1	Yes	Yes	6	7	1	1
R:R:Q126	R:R:W269	7.67	1	Yes	Yes	7	8	1	2
R:R:F127	R:R:V173	3.93	1	Yes	No	6	4	1	2
R:R:F127	R:R:T212	3.89	1	Yes	Yes	6	4	1	1
R:R:F127	R:R:G216	3.01	1	Yes	No	6	6	1	2
R:R:F208	R:R:I177	5.02	1	Yes	No	7	3	1	2
R:R:I195	R:R:T194	3.04	0	No	No	5	4	2	1
R:R:I195	R:R:Y205	6.04	0	No	No	5	4	2	1
R:R:F208	R:R:T212	3.89	1	Yes	Yes	7	4	1	1
R:R:I209	R:R:N276	7.08	0	Yes	No	5	6	1	1
R:R:I209	R:R:V277	3.07	0	Yes	No	5	5	1	2
R:R:I209	R:R:V280	3.07	0	Yes	No	5	4	1	2
R:R:T212	R:R:Y273	6.24	1	Yes	Yes	4	7	1	2
R:R:W269	R:R:Y273	4.82	1	Yes	Yes	8	7	2	2
R:R:T301	R:R:W269	12.13	0	No	Yes	7	8	2	2
R:R:F272	R:R:Y273	8.25	1	Yes	Yes	6	7	1	2
R:R:F272	R:R:V298	3.93	1	Yes	Yes	6	6	1	1
R:R:F272	R:R:T301	6.49	1	Yes	No	6	7	1	2
R:R:F275	R:R:F294	3.22	0	No	Yes	4	4	2	1
R:R:F294	R:R:N276	4.83	0	Yes	No	4	6	1	1
R:R:F294	R:R:V298	5.24	0	Yes	Yes	4	6	1	1
R:R:T301	R:R:Y302	3.75	0	No	Yes	7	7	2	1
R:R:W197	R:R:Y205	1.93	9	Yes	No	5	4	2	1
L:L:Y3	R:R:S279	1.27	0	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XAV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	268
Number of Links	307
Number of Hubs	45
Number of Links mediated by Hubs	158
Number of Communities	9
Number of Nodes involved in Communities	58
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	50174
Length Of Smallest Path	3
Average Path Length	13.2566
Length of Longest Path	33
Minimum Path Strength	1.39
Average Path Strength	6.83301
Maximum Path Strength	27.55
Minimum Path Correlation	0.7
Average Path Correlation	0.924103
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	50.2718
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.508
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7XAV_nogp_Chain_R S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	doi.org/10.1038/s41421-022-00405-2
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	doi.org/10.1038/s41422-022-00669-z
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	doi.org/10.1038/s41422-022-00679-x
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	doi.org/10.1038/s41467-023-36673-z
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	doi.org/10.7554/eLife.76823
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5

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