psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C2	L:L:C7	7.28	No	No	0	0	0
2	L:L:C2	R:R:F294	8.38	No	Yes	0	0	4
3	L:L:Y3	R:R:Y205	24.82	Yes	No	0	0	4
4	L:L:Y3	R:R:F208	9.28	Yes	Yes	0	0	7
5	L:L:Y3	R:R:I209	6.04	Yes	Yes	0	0	5
6	L:L:?4	L:L:K5	19.03	Yes	Yes	1	0	0
7	L:L:?4	R:R:Q126	4.23	Yes	Yes	1	0	7
8	L:L:?4	R:R:F127	4.83	Yes	Yes	1	0	6
9	L:L:?4	R:R:F208	13.53	Yes	Yes	1	0	7
10	L:L:?4	R:R:T212	14.04	Yes	Yes	1	0	4
11	L:L:?4	R:R:F272	5.8	Yes	Yes	1	0	6
12	L:L:?4	R:R:N276	5.45	Yes	No	0	0	6
13	L:L:K5	R:R:Q126	4.07	Yes	Yes	1	0	7
14	L:L:K5	R:R:F272	3.72	Yes	Yes	1	0	6
15	L:L:K5	R:R:V298	4.55	Yes	Yes	1	0	6
16	L:L:K5	R:R:Y302	5.97	Yes	Yes	1	0	7
17	L:L:V6	R:R:T194	4.76	No	No	0	0	4
18	R:R:N43	R:R:T47	4.39	No	No	0	3	5
19	R:R:G292	R:R:L46	3.42	No	No	0	1	5
20	R:R:F296	R:R:L46	8.53	No	No	0	5	5
21	R:R:T47	R:R:V103	4.76	No	No	0	5	4
22	R:R:A104	R:R:T47	5.03	No	No	0	5	5
23	R:R:F48	R:R:V52	7.87	No	No	0	6	5
24	R:R:F296	R:R:I49	13.82	No	No	0	5	5
25	R:R:L96	R:R:Y50	4.69	Yes	Yes	0	7	7
26	R:R:V298	R:R:Y50	5.05	Yes	Yes	0	6	7
27	R:R:V299	R:R:Y50	21.45	No	Yes	0	5	7
28	R:R:I56	R:R:V53	3.07	Yes	No	0	4	7
29	R:R:C54	R:R:M93	4.86	No	Yes	1	6	6
30	R:R:C54	R:R:L96	6.35	No	Yes	1	6	7
31	R:R:I55	R:R:I56	4.42	No	Yes	0	4	4
32	R:R:C306	R:R:I56	6.55	No	Yes	0	8	4
33	R:R:G57	R:R:M93	3.49	No	Yes	0	8	6
34	R:R:L58	R:R:M93	8.48	No	Yes	0	6	6
35	R:R:L58	R:R:L94	5.54	No	No	0	6	5
36	R:R:G60	R:R:P309	4.06	No	No	0	8	9
37	R:R:A86	R:R:N61	4.69	No	Yes	0	9	9
38	R:R:D89	R:R:N61	17.5	No	Yes	0	9	9
39	R:R:E90	R:R:N61	9.2	No	Yes	0	7	9
40	R:R:N61	R:R:P309	14.66	Yes	No	0	9	9
41	R:R:E90	R:R:T62	8.47	No	No	0	7	5
42	R:R:F323	R:R:L63	7.31	No	No	0	6	6
43	R:R:A86	R:R:V64	3.39	No	No	0	9	9
44	R:R:A313	R:R:V64	3.39	No	No	4	7	9
45	R:R:F319	R:R:V64	5.24	Yes	No	4	8	9
46	R:R:I65	R:R:L69	5.71	No	No	5	7	3
47	R:R:I65	R:R:L83	4.28	No	Yes	5	7	6
48	R:R:A86	R:R:I65	3.25	No	No	0	9	7
49	R:R:F319	R:R:V67	10.49	Yes	No	0	8	7
50	R:R:F323	R:R:V67	5.24	No	No	0	6	7
51	R:R:I68	R:R:L83	9.99	No	Yes	0	7	6
52	R:R:F319	R:R:I68	5.02	Yes	No	0	8	7
53	R:R:L69	R:R:L83	4.15	No	Yes	5	3	6
54	R:R:R70	R:R:Y71	3.09	No	No	0	4	6
55	R:R:V326	R:R:Y71	15.14	No	No	0	5	6
56	R:R:K73	R:R:T76	16.52	No	No	3	5	7
57	R:R:K73	R:R:N79	13.99	No	Yes	3	5	8
58	R:R:K73	R:R:N318	6.99	No	No	3	5	5
59	R:R:K75	R:R:P156	18.4	No	No	0	7	3
60	R:R:N79	R:R:T76	7.31	Yes	No	3	8	7
61	R:R:I77	R:R:Y81	3.63	No	Yes	6	4	7
62	R:R:I77	R:R:P156	5.08	No	No	0	4	3
63	R:R:A159	R:R:I77	3.25	No	No	6	7	4
64	R:R:N79	R:R:T78	4.39	Yes	No	0	8	8
65	R:R:N318	R:R:N79	4.09	No	Yes	3	5	8
66	R:R:A159	R:R:I80	3.25	No	No	0	7	5
67	R:R:I80	R:R:T163	3.04	No	Yes	0	5	7
68	R:R:M136	R:R:Y81	7.18	Yes	Yes	0	9	7
69	R:R:D139	R:R:Y81	9.2	No	Yes	0	8	7
70	R:R:A159	R:R:Y81	4	No	Yes	6	7	7
71	R:R:I162	R:R:Y81	3.63	No	Yes	0	5	7
72	R:R:T163	R:R:Y81	4.99	Yes	Yes	0	7	7
73	R:R:I82	R:R:M136	5.83	No	Yes	0	8	9
74	R:R:A313	R:R:I82	3.25	No	No	0	7	8
75	R:R:I87	R:R:L83	4.28	No	Yes	0	7	6
76	R:R:C132	R:R:N84	6.3	No	No	0	8	9
77	R:R:N84	R:R:T163	10.24	No	Yes	0	9	7
78	R:R:N84	R:R:W167	11.3	No	Yes	0	9	9
79	R:R:C132	R:R:L85	3.17	No	Yes	0	8	9
80	R:R:L133	R:R:L85	4.15	No	Yes	1	9	9
81	R:R:L85	R:R:M136	4.24	Yes	Yes	0	9	9
82	R:R:L85	R:R:N308	10.98	Yes	Yes	1	9	9
83	R:R:I87	R:R:W167	3.52	No	Yes	0	7	9
84	R:R:A88	R:R:T128	3.36	No	No	0	8	7
85	R:R:D89	R:R:S305	10.31	No	No	0	9	8
86	R:R:D89	R:R:N308	5.39	No	Yes	0	9	9
87	R:R:L91	R:R:L94	5.54	No	No	0	7	5
88	R:R:L91	R:R:N125	13.73	No	Yes	0	7	7
89	R:R:D122	R:R:F92	15.52	No	Yes	1	6	6
90	R:R:F92	R:R:N125	3.62	Yes	Yes	0	6	7
91	R:R:F92	R:R:Q126	14.05	Yes	Yes	1	6	7
92	R:R:F92	R:R:Y302	22.69	Yes	Yes	1	6	7
93	R:R:L96	R:R:M93	5.65	Yes	Yes	1	7	6
94	R:R:D122	R:R:G95	5.03	No	No	0	6	6
95	R:R:L96	R:R:Y302	16.41	Yes	Yes	1	7	7
96	R:R:F98	R:R:W108	17.04	No	Yes	2	5	8
97	R:R:F98	R:R:I114	7.54	No	No	2	5	6
98	R:R:F98	R:R:V118	9.18	No	No	0	5	5
99	R:R:Q102	R:R:W108	18.62	Yes	Yes	2	5	8
100	R:R:Q102	R:R:S192	4.33	Yes	No	0	5	4
101	R:R:C193	R:R:Q102	4.58	No	Yes	2	9	5
102	R:R:D295	R:R:V103	4.38	No	No	0	2	4
103	R:R:H107	R:R:L105	11.57	No	No	0	4	5
104	R:R:R190	R:R:V106	9.15	No	No	0	1	4
105	R:R:H107	R:R:R190	10.16	No	No	0	4	1
106	R:R:P109	R:R:W108	36.48	No	Yes	0	4	8
107	R:R:I114	R:R:W108	15.27	No	Yes	2	6	8
108	R:R:C115	R:R:W108	15.67	No	Yes	2	9	8
109	R:R:C193	R:R:W108	5.22	No	Yes	2	9	8
110	R:R:F110	R:R:K112	4.96	No	No	0	6	3
111	R:R:G111	R:R:L183	5.13	No	No	0	7	4
112	R:R:A113	R:R:K112	4.82	No	No	0	1	3
113	R:R:C115	R:R:C193	7.28	No	No	2	9	9
114	R:R:A181	R:R:R116	6.91	No	No	0	4	6
115	R:R:T120	R:R:V117	4.76	No	No	0	6	5
116	R:R:I174	R:R:T120	4.56	No	No	0	7	6
117	R:R:N125	R:R:V121	4.43	Yes	No	0	7	5
118	R:R:D122	R:R:Y302	9.2	No	Yes	1	6	7
119	R:R:G123	R:R:I174	3.53	No	No	0	4	7
120	R:R:I124	R:R:N125	7.08	No	Yes	0	5	7
121	R:R:I124	R:R:S170	4.64	No	No	0	5	7
122	R:R:N125	R:R:W167	6.78	Yes	Yes	0	7	9
123	R:R:F127	R:R:Q126	7.03	Yes	Yes	1	6	7
124	R:R:Q126	R:R:W269	7.67	Yes	Yes	1	7	8
125	R:R:F127	R:R:V173	3.93	Yes	No	0	6	4
126	R:R:F127	R:R:T212	3.89	Yes	Yes	1	6	4
127	R:R:F127	R:R:G216	3.01	Yes	No	0	6	6
128	R:R:T128	R:R:W167	12.13	No	Yes	0	7	9
129	R:R:S170	R:R:T128	3.2	No	No	0	7	7
130	R:R:S129	R:R:S305	3.26	No	No	0	9	8
131	R:R:I130	R:R:W269	4.7	No	Yes	0	8	8
132	R:R:F131	R:R:T134	3.89	No	Yes	7	6	7
133	R:R:F131	R:R:P220	4.33	No	No	7	6	9
134	R:R:L133	R:R:N308	4.12	No	Yes	1	9	9
135	R:R:L133	R:R:Y312	5.86	No	Yes	1	9	9
136	R:R:P220	R:R:T134	3.5	No	Yes	7	9	7
137	R:R:I223	R:R:T134	4.56	No	Yes	0	6	7
138	R:R:I224	R:R:T134	6.08	No	Yes	0	7	7
139	R:R:M136	R:R:Y312	4.79	Yes	Yes	0	9	9
140	R:R:I224	R:R:S137	6.19	No	No	0	7	9
141	R:R:S137	R:R:Y228	11.45	No	Yes	0	9	9
142	R:R:D139	R:R:R154	10.72	No	No	0	8	5
143	R:R:R140	R:R:Y228	9.26	No	Yes	1	9	9
144	R:R:R140	R:R:Y312	8.23	No	Yes	1	9	9
145	R:R:V145	R:R:Y141	12.62	No	Yes	8	7	8
146	R:R:H146	R:R:Y141	7.62	No	Yes	8	5	8
147	R:R:C227	R:R:Y141	8.06	No	Yes	0	7	8
148	R:R:F230	R:R:Y141	8.25	No	Yes	0	4	8
149	R:R:L142	R:R:S150	4.5	No	No	0	4	5
150	R:R:A143	R:R:R154	5.53	No	No	0	8	5
151	R:R:I231	R:R:V144	9.22	No	No	0	9	8
152	R:R:H146	R:R:V145	9.69	No	No	8	5	7
153	R:R:K234	R:R:V145	4.55	No	No	0	5	7
154	R:R:K152	R:R:W153	8.12	No	No	0	4	3
155	R:R:R155	R:R:R157	4.26	No	No	0	6	4
156	R:R:R155	R:R:T158	3.88	No	No	0	6	5
157	R:R:G168	R:R:L171	3.42	No	No	0	4	3
158	R:R:V173	R:R:Y211	7.57	No	No	0	4	4
159	R:R:I174	R:R:I177	4.42	No	No	0	7	3
160	R:R:L175	R:R:M178	4.24	No	No	0	4	5
161	R:R:F208	R:R:I177	5.02	Yes	No	0	7	3
162	R:R:I179	R:R:Y180	13.3	No	No	0	4	4
163	R:R:W197	R:R:Y180	12.54	Yes	No	9	5	4
164	R:R:P198	R:R:Y180	11.13	No	No	9	5	4
165	R:R:G182	R:R:N196	5.09	No	No	0	5	3
166	R:R:N196	R:R:R184	9.64	No	No	0	3	2
167	R:R:S185	R:R:S191	6.52	No	No	0	2	5
168	R:R:N186	R:R:Q187	5.28	No	No	0	1	2
169	R:R:Q187	R:R:W188	7.67	No	No	0	2	2
170	R:R:I195	R:R:T194	3.04	No	No	0	5	4
171	R:R:I195	R:R:Y205	6.04	No	No	0	5	4
172	R:R:P198	R:R:W197	16.21	No	Yes	9	5	5
173	R:R:T206	R:R:V280	3.17	No	No	0	3	4
174	R:R:G207	R:R:I210	3.53	No	No	0	4	5
175	R:R:F208	R:R:T212	3.89	Yes	Yes	1	7	4
176	R:R:I209	R:R:N276	7.08	Yes	No	0	5	6
177	R:R:I209	R:R:V277	3.07	Yes	No	0	5	5
178	R:R:I209	R:R:V280	3.07	Yes	No	0	5	4
179	R:R:L215	R:R:Y211	3.52	No	No	0	4	4
180	R:R:T212	R:R:Y273	6.24	Yes	Yes	1	4	7
181	R:R:F213	R:R:F217	15	No	Yes	1	5	8
182	R:R:F213	R:R:L218	6.09	No	No	1	5	4
183	R:R:F213	R:R:Y273	20.63	No	Yes	1	5	7
184	R:R:F217	R:R:L218	4.87	Yes	No	1	8	4
185	R:R:F217	R:R:L221	3.65	Yes	Yes	1	8	6
186	R:R:F217	R:R:F265	5.36	Yes	Yes	1	8	9
187	R:R:F217	R:R:I266	3.77	Yes	No	1	8	6
188	R:R:F217	R:R:W269	3.01	Yes	Yes	1	8	8
189	R:R:F217	R:R:L270	3.65	Yes	Yes	1	8	5
190	R:R:F217	R:R:Y273	3.09	Yes	Yes	1	8	7
191	R:R:P220	R:R:V219	3.53	No	No	0	9	5
192	R:R:C225	R:R:L221	3.17	No	Yes	0	5	6
193	R:R:F265	R:R:L221	7.31	Yes	Yes	1	9	6
194	R:R:I266	R:R:L221	4.28	No	Yes	1	6	6
195	R:R:C225	R:R:V262	3.42	No	No	0	5	7
196	R:R:V258	R:R:Y228	8.83	No	Yes	0	8	9
197	R:R:V261	R:R:Y228	3.79	No	Yes	0	8	9
198	R:R:Y228	R:R:Y312	4.96	Yes	Yes	1	9	9
199	R:R:F230	R:R:L229	3.65	No	No	0	4	4
200	R:R:F230	R:R:I233	6.28	No	No	0	4	3
201	R:R:I232	R:R:T255	3.04	No	No	0	5	7
202	R:R:V235	R:R:V254	6.41	No	No	0	8	8
203	R:R:E251	R:R:K236	22.95	Yes	No	0	6	4
204	R:R:I240	R:R:S237	3.1	No	No	0	3	5
205	R:R:G239	R:R:S244	3.71	No	No	0	5	3
206	R:R:G243	R:R:S244	3.71	No	No	0	1	3
207	R:R:K253	R:R:M257	4.32	No	No	0	7	8
208	R:R:L315	R:R:M257	11.31	No	No	0	6	8
209	R:R:I260	R:R:L311	4.28	No	Yes	0	6	8
210	R:R:L311	R:R:V261	7.45	Yes	No	0	8	8
211	R:R:L311	R:R:V264	4.47	Yes	No	0	8	7
212	R:R:F265	R:R:W269	6.01	Yes	Yes	1	9	8
213	R:R:F265	R:R:N304	4.83	Yes	Yes	1	9	9
214	R:R:I266	R:R:L270	4.28	No	Yes	1	6	5
215	R:R:C268	R:R:N304	4.72	No	Yes	0	8	9
216	R:R:W269	R:R:Y273	4.82	Yes	Yes	1	8	7
217	R:R:T301	R:R:W269	12.13	No	Yes	0	7	8
218	R:R:N304	R:R:W269	7.91	Yes	Yes	1	9	8
219	R:R:L270	R:R:P271	8.21	Yes	No	0	5	9
220	R:R:I274	R:R:L270	5.71	No	Yes	0	5	5
221	R:R:P271	R:R:V297	3.53	No	No	0	9	7
222	R:R:F272	R:R:Y273	8.25	Yes	Yes	1	6	7
223	R:R:F272	R:R:V298	3.93	Yes	Yes	1	6	6
224	R:R:F272	R:R:T301	6.49	Yes	No	0	6	7
225	R:R:F275	R:R:F294	3.22	No	Yes	0	4	4
226	R:R:F275	R:R:V297	9.18	No	No	0	4	7
227	R:R:F294	R:R:N276	4.83	Yes	No	0	4	6
228	R:R:P288	R:R:T287	5.25	No	Yes	0	3	1
229	R:R:L290	R:R:T287	5.9	No	Yes	0	4	1
230	R:R:F294	R:R:V298	5.24	Yes	Yes	0	4	6
231	R:R:T301	R:R:Y302	3.75	No	Yes	0	7	7
232	R:R:N304	R:R:N308	8.17	Yes	Yes	1	9	9
233	R:R:A313	R:R:F319	5.55	No	Yes	4	7	8
234	R:R:F314	R:R:K320	7.44	No	No	0	7	8
235	R:R:N318	R:R:S316	5.96	No	No	0	5	8
236	R:R:D317	R:R:K320	6.91	No	No	0	5	8
237	R:R:K160	R:R:T163	3	No	Yes	0	1	7
238	R:R:I138	R:R:I223	2.94	No	No	0	6	6
239	R:R:I240	R:R:K248	2.91	No	No	0	3	3
240	R:R:D139	R:R:T78	2.89	No	No	0	8	8
241	R:R:P156	R:R:R155	2.88	No	No	0	3	6
242	R:R:K249	R:R:K252	2.87	No	No	0	4	5
243	R:R:I138	R:R:L142	2.85	No	No	0	6	4
244	R:R:I214	R:R:L218	2.85	No	No	0	4	4
245	R:R:L105	R:R:M101	2.83	No	No	0	5	5
246	R:R:L171	R:R:L172	2.77	No	No	0	3	3
247	R:R:L172	R:R:L175	2.77	No	No	0	3	4
248	R:R:L46	R:R:N43	2.75	No	No	0	5	3
249	R:R:P176	R:R:W197	2.7	No	Yes	0	8	5
250	R:R:E251	R:R:K248	2.7	Yes	No	0	6	3
251	R:R:A100	R:R:Y50	2.67	No	Yes	0	6	7
252	R:R:L99	R:R:Q102	2.66	No	Yes	0	6	5
253	R:R:F131	R:R:V169	2.62	No	No	0	6	4
254	R:R:F296	R:R:V299	2.62	No	No	0	5	5
255	R:R:V135	R:R:Y81	2.52	No	Yes	0	7	7
256	R:R:F275	R:R:M293	2.49	No	No	0	4	4
257	R:R:K249	R:R:R247	2.48	No	No	0	4	4
258	R:R:I231	R:R:Y228	2.42	No	Yes	0	9	9
259	R:R:N186	R:R:R184	2.41	No	No	0	1	2
260	R:R:F314	R:R:F323	2.14	No	No	0	7	6
261	R:R:C59	R:R:G60	1.96	No	No	0	5	8
262	R:R:C115	R:R:G111	1.96	No	No	0	9	7
263	R:R:W197	R:R:Y205	1.93	Yes	No	0	5	4
264	R:R:C54	R:R:P97	1.88	No	No	0	6	8
265	R:R:G189	R:R:S185	1.86	No	No	0	6	2
266	R:R:G239	R:R:S238	1.86	No	No	0	5	5
267	R:R:G95	R:R:V118	1.84	No	No	0	6	5
268	R:R:G243	R:R:V242	1.84	No	No	0	1	3
269	R:R:G207	R:R:T206	1.82	No	No	0	4	3
270	R:R:P286	R:R:S285	1.78	No	No	0	2	2
271	R:R:G57	R:R:I56	1.76	No	Yes	0	8	4
272	R:R:C227	R:R:S137	1.72	No	No	0	7	9
273	R:R:C132	R:R:V166	1.71	No	No	0	8	6
274	R:R:A44	R:R:V45	1.7	No	No	0	4	5
275	R:R:A307	R:R:V264	1.7	No	No	0	6	7
276	R:R:A289	R:R:T287	1.68	No	Yes	0	1	1
277	R:R:L175	R:R:P176	1.64	No	No	0	4	8
278	R:R:S322	R:R:V67	1.62	No	No	0	5	7
279	R:R:A72	R:R:M74	1.61	No	No	0	5	7
280	R:R:A283	R:R:M282	1.61	No	No	0	4	3
281	R:R:S259	R:R:T255	1.6	No	No	0	4	7
282	R:R:S285	R:R:T287	1.6	No	Yes	0	2	1
283	R:R:A104	R:R:L105	1.58	No	No	0	5	5
284	R:R:I231	R:R:V254	1.54	No	No	0	9	8
285	R:R:I232	R:R:V254	1.54	No	No	0	5	8
286	R:R:I232	R:R:V258	1.54	No	No	0	5	8
287	R:R:H146	R:R:P147	1.53	No	No	0	5	8
288	R:R:M161	R:R:T158	1.51	No	No	0	1	5
289	R:R:G189	R:R:R190	1.5	No	No	0	6	1
290	R:R:L300	R:R:V297	1.49	No	No	0	7	7
291	R:R:N325	R:R:V326	1.48	No	No	0	4	5
292	R:R:L226	R:R:T222	1.47	No	No	0	5	4
293	R:R:I177	R:R:M119	1.46	No	No	0	3	5
294	R:R:K75	R:R:M74	1.44	No	No	0	7	7
295	R:R:E251	R:R:V235	1.43	Yes	No	0	6	8
296	R:R:I284	R:R:L290	1.43	No	No	0	1	4
297	R:R:D295	R:R:K291	1.38	No	No	0	2	3
298	R:R:L311	R:R:L315	1.38	Yes	No	0	8	6
299	R:R:K320	R:R:Q324	1.36	No	No	0	8	4
300	R:R:E251	R:R:K252	1.35	Yes	No	0	6	5
301	R:R:R184	R:R:S185	1.32	No	No	0	2	2
302	R:R:R241	R:R:S237	1.32	No	No	0	1	5
303	L:L:Y3	R:R:S279	1.27	Yes	No	0	0	4
304	R:R:S322	R:R:Y71	1.27	No	No	0	5	6
305	R:R:F110	R:R:I114	1.26	No	No	0	6	6
306	R:R:T206	R:R:W204	1.21	No	No	0	3	3
307	R:R:F48	R:R:F51	1.07	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y3	10.3525	4	0	0
2	L:L:?4	9.55857	7	1	0
3	L:L:K5	7.468	5	1	0
4	R:R:Y50	8.465	4	0	7
5	R:R:I56	3.95	4	0	4
6	R:R:N61	11.5125	4	0	9
7	R:R:N79	7.445	4	3	8
8	R:R:Y81	5.02143	7	6	7
9	R:R:L83	5.675	4	5	6
10	R:R:L85	5.635	4	1	9
11	R:R:F92	13.97	4	1	6
12	R:R:M93	5.62	4	1	6
13	R:R:L96	8.275	4	1	7
14	R:R:Q102	7.5475	4	2	5
15	R:R:W108	18.05	6	2	8
16	R:R:N125	7.128	5	0	7
17	R:R:Q126	7.41	5	1	7
18	R:R:F127	4.538	5	1	6
19	R:R:T134	4.5075	4	7	7
20	R:R:M136	5.51	4	0	9
21	R:R:Y141	9.1375	4	8	8
22	R:R:T163	5.3175	4	0	7
23	R:R:W167	8.4325	4	0	9
24	R:R:W197	8.345	4	9	5
25	R:R:F208	7.93	4	1	7
26	R:R:I209	4.815	4	0	5
27	R:R:T212	7.015	4	1	4
28	R:R:F217	5.3	8	1	8
29	R:R:L221	4.6025	4	1	6
30	R:R:Y228	6.785	6	1	9
31	R:R:E251	7.1075	4	0	6
32	R:R:F265	5.8775	4	1	9
33	R:R:W269	6.60714	7	1	8
34	R:R:L270	5.4625	4	1	5
35	R:R:F272	5.638	5	1	6
36	R:R:Y273	8.606	5	1	7
37	R:R:T287	3.6075	4	0	1
38	R:R:F294	5.4175	4	0	4
39	R:R:V298	4.6925	4	1	6
40	R:R:Y302	11.604	5	1	7
41	R:R:N304	6.4075	4	1	9
42	R:R:N308	7.165	4	1	9
43	R:R:L311	4.395	4	0	8
44	R:R:Y312	5.96	4	1	9
45	R:R:F319	6.575	4	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I209	R:R:N276	12.0009	7.08	Yes	No	0	5	6
2	L:L:Y3	R:R:Y205	27.0191	24.82	Yes	No	0	0	4
3	L:L:?4	R:R:N276	12.8131	5.45	Yes	No	0	0	6
4	L:L:?4	R:R:F208	27.2096	13.53	Yes	Yes	1	0	7
5	R:R:F294	R:R:V298	14.7414	5.24	Yes	Yes	0	4	6
6	R:R:F272	R:R:V298	28.4483	3.93	Yes	Yes	1	6	6
7	L:L:K5	R:R:V298	19.7096	4.55	Yes	Yes	1	0	6
8	R:R:V298	R:R:Y50	40.8485	5.05	Yes	Yes	0	6	7
9	R:R:V299	R:R:Y50	55.5762	21.45	No	Yes	0	5	7
10	R:R:F296	R:R:V299	53.4619	2.62	No	No	0	5	5
11	R:R:F296	R:R:L46	49.206	8.53	No	No	0	5	5
12	R:R:L46	R:R:N43	44.9138	2.75	No	No	0	5	3
13	R:R:N43	R:R:T47	42.7541	4.39	No	No	0	3	5
14	R:R:A104	R:R:T47	34.0245	5.03	No	No	0	5	5
15	R:R:L96	R:R:Y50	20.667	4.69	Yes	Yes	0	7	7
16	L:L:?4	R:R:Q126	28.5163	4.23	Yes	Yes	1	0	7
17	R:R:Q126	R:R:W269	38.8113	7.67	Yes	Yes	1	7	8
18	R:R:N304	R:R:W269	91.8466	7.91	Yes	Yes	1	9	8
19	R:R:N304	R:R:N308	100	8.17	Yes	Yes	1	9	9
20	R:R:D89	R:R:N308	20.4129	5.39	No	Yes	0	9	9
21	R:R:D89	R:R:N61	15.6624	17.5	No	Yes	0	9	9
22	L:L:K5	R:R:Q126	14.6143	4.07	Yes	Yes	1	0	7
23	R:R:F272	R:R:Y273	14.9773	8.25	Yes	Yes	1	6	7
24	R:R:W269	R:R:Y273	23.5889	4.82	Yes	Yes	1	8	7
25	R:R:F272	R:R:T301	12.4909	6.49	Yes	No	0	6	7
26	R:R:T301	R:R:W269	31.4564	12.13	No	Yes	0	7	8
27	R:R:F92	R:R:Q126	25.2541	14.05	Yes	Yes	1	6	7
28	R:R:F92	R:R:N125	32.3593	3.62	Yes	Yes	0	6	7
29	R:R:N125	R:R:W167	35.7895	6.78	Yes	Yes	0	7	9
30	R:R:I87	R:R:W167	14.206	3.52	No	Yes	0	7	9
31	R:R:I87	R:R:L83	12.7858	4.28	No	Yes	0	7	6
32	R:R:I68	R:R:L83	10.1543	9.99	No	Yes	0	7	6
33	R:R:F319	R:R:V67	16.765	10.49	Yes	No	0	8	7
34	R:R:F92	R:R:Y302	12.6679	22.69	Yes	Yes	1	6	7
35	R:R:L85	R:R:N308	23.294	10.98	Yes	Yes	1	9	9
36	R:R:L85	R:R:M136	24.1016	4.24	Yes	Yes	0	9	9
37	R:R:I82	R:R:M136	12.2505	5.83	No	Yes	0	8	9
38	R:R:A313	R:R:I82	10.4764	3.25	No	No	0	7	8
39	R:R:N84	R:R:W167	25.9256	11.3	No	Yes	0	9	9
40	R:R:N84	R:R:T163	19.6461	10.24	No	Yes	0	9	7
41	R:R:T163	R:R:Y81	17.9673	4.99	Yes	Yes	0	7	7
42	R:R:D139	R:R:Y81	14.3966	9.2	No	Yes	0	8	7
43	R:R:M136	R:R:Y81	25.3403	7.18	Yes	Yes	0	9	7
44	R:R:I77	R:R:Y81	14.5327	3.63	No	Yes	6	4	7
45	R:R:I77	R:R:P156	13.0263	5.08	No	No	0	4	3
46	R:R:L133	R:R:N308	64.0744	4.12	No	Yes	1	9	9
47	R:R:D122	R:R:Y302	13.0082	9.2	No	Yes	1	6	7
48	R:R:D122	R:R:G95	25.8757	5.03	No	No	0	6	6
49	R:R:G95	R:R:V118	24.3103	1.84	No	No	0	6	5
50	R:R:F98	R:R:V118	22.863	9.18	No	No	0	5	5
51	R:R:F98	R:R:W108	14.6915	17.04	No	Yes	2	5	8
52	R:R:A104	R:R:L105	31.8194	1.58	No	No	0	5	5
53	R:R:H107	R:R:L105	27.382	11.57	No	No	0	4	5
54	R:R:H107	R:R:R190	25.1497	10.16	No	No	0	4	1
55	R:R:F208	R:R:I177	10.9664	5.02	Yes	No	0	7	3
56	R:R:L133	R:R:Y312	66.4292	5.86	No	Yes	1	9	9
57	R:R:Y228	R:R:Y312	79.5145	4.96	Yes	Yes	1	9	9
58	R:R:S137	R:R:Y228	37.1642	11.45	No	Yes	0	9	9
59	R:R:I224	R:R:S137	19.0971	6.19	No	No	0	7	9
60	R:R:I224	R:R:T134	17.2278	6.08	No	Yes	0	7	7
61	R:R:C227	R:R:S137	17.1007	1.72	No	No	0	7	9
62	R:R:C227	R:R:Y141	15.2223	8.06	No	Yes	0	7	8
63	R:R:I231	R:R:Y228	24.02	2.42	No	Yes	0	9	9
64	R:R:W197	R:R:Y205	19.6869	1.93	Yes	No	0	5	4
65	R:R:P176	R:R:W197	11.9192	2.7	No	Yes	0	8	5
66	R:R:G189	R:R:R190	20.6579	1.5	No	No	0	6	1
67	R:R:G189	R:R:S185	18.3984	1.86	No	No	0	6	2
68	R:R:R184	R:R:S185	13.8521	1.32	No	No	0	2	2
69	R:R:V261	R:R:Y228	15.2813	3.79	No	Yes	0	8	9
70	R:R:I231	R:R:V254	20.4991	1.54	No	No	0	9	8
71	R:R:V235	R:R:V254	18.9338	6.41	No	No	0	8	8
72	R:R:E251	R:R:V235	17.0735	1.43	Yes	No	0	6	8
73	R:R:L311	R:R:V261	13.4165	7.45	Yes	No	0	8	8
74	L:L:Y3	R:R:F208	28.1352	9.28	Yes	Yes	0	0	7
75	R:R:F208	R:R:T212	12.2777	3.89	Yes	Yes	1	7	4
76	R:R:L96	R:R:Y302	28.0127	16.41	Yes	Yes	1	7	7
77	R:R:T212	R:R:Y273	13.2577	6.24	Yes	Yes	1	4	7
78	R:R:D122	R:R:F92	14.4192	15.52	No	Yes	1	6	6
79	R:R:F217	R:R:W269	10.7123	3.01	Yes	Yes	1	8	8
80	R:R:T301	R:R:Y302	20.118	3.75	No	Yes	0	7	7
81	R:R:M136	R:R:Y312	16.6652	4.79	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C2	R:R:F294	8.38	0	No	Yes	0	4	0	1
L:L:Y3	R:R:Y205	24.82	0	Yes	No	0	4	0	1
L:L:Y3	R:R:F208	9.28	0	Yes	Yes	0	7	0	1
L:L:Y3	R:R:I209	6.04	0	Yes	Yes	0	5	0	1
L:L:?4	R:R:Q126	4.23	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:F127	4.83	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:F208	13.53	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:T212	14.04	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:F272	5.8	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N276	5.45	1	Yes	No	0	6	0	1
L:L:K5	R:R:Q126	4.07	1	Yes	Yes	0	7	0	1
L:L:K5	R:R:F272	3.72	1	Yes	Yes	0	6	0	1
L:L:K5	R:R:V298	4.55	1	Yes	Yes	0	6	0	1
L:L:K5	R:R:Y302	5.97	1	Yes	Yes	0	7	0	1
L:L:V6	R:R:T194	4.76	0	No	No	0	4	0	1
R:R:L96	R:R:Y50	4.69	1	Yes	Yes	7	7	2	2
R:R:V298	R:R:Y50	5.05	1	Yes	Yes	6	7	1	2
R:R:D122	R:R:F92	15.52	1	No	Yes	6	6	2	2
R:R:F92	R:R:Q126	14.05	1	Yes	Yes	6	7	2	1
R:R:F92	R:R:Y302	22.69	1	Yes	Yes	6	7	2	1
R:R:L96	R:R:Y302	16.41	1	Yes	Yes	7	7	2	1
R:R:D122	R:R:Y302	9.2	1	No	Yes	6	7	2	1
R:R:F127	R:R:Q126	7.03	1	Yes	Yes	6	7	1	1
R:R:Q126	R:R:W269	7.67	1	Yes	Yes	7	8	1	2
R:R:F127	R:R:V173	3.93	1	Yes	No	6	4	1	2
R:R:F127	R:R:T212	3.89	1	Yes	Yes	6	4	1	1
R:R:F127	R:R:G216	3.01	1	Yes	No	6	6	1	2
R:R:F208	R:R:I177	5.02	1	Yes	No	7	3	1	2
R:R:I195	R:R:T194	3.04	0	No	No	5	4	2	1
R:R:I195	R:R:Y205	6.04	0	No	No	5	4	2	1
R:R:F208	R:R:T212	3.89	1	Yes	Yes	7	4	1	1
R:R:I209	R:R:N276	7.08	0	Yes	No	5	6	1	1
R:R:I209	R:R:V277	3.07	0	Yes	No	5	5	1	2
R:R:I209	R:R:V280	3.07	0	Yes	No	5	4	1	2
R:R:T212	R:R:Y273	6.24	1	Yes	Yes	4	7	1	2
R:R:W269	R:R:Y273	4.82	1	Yes	Yes	8	7	2	2
R:R:T301	R:R:W269	12.13	0	No	Yes	7	8	2	2
R:R:F272	R:R:Y273	8.25	1	Yes	Yes	6	7	1	2
R:R:F272	R:R:V298	3.93	1	Yes	Yes	6	6	1	1
R:R:F272	R:R:T301	6.49	1	Yes	No	6	7	1	2
R:R:F275	R:R:F294	3.22	0	No	Yes	4	4	2	1
R:R:F294	R:R:N276	4.83	0	Yes	No	4	6	1	1
R:R:F294	R:R:V298	5.24	0	Yes	Yes	4	6	1	1
R:R:T301	R:R:Y302	3.75	0	No	Yes	7	7	2	1
R:R:W197	R:R:Y205	1.93	9	Yes	No	5	4	2	1
L:L:Y3	R:R:S279	1.27	0	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XAV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	268
Number of Links	307
Number of Hubs	45
Number of Links mediated by Hubs	158
Number of Communities	9
Number of Nodes involved in Communities	58
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	50174
Length Of Smallest Path	3
Average Path Length	13.2566
Length of Longest Path	33
Minimum Path Strength	1.39
Average Path Strength	6.83301
Maximum Path Strength	27.55
Minimum Path Correlation	0.7
Average Path Correlation	0.924095
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	50.2038
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.508
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cerebellum development • metencephalon development • hindbrain development • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to hormone • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid DTR D-Tryptophan (R)-tryptophan
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7XAV_nogp_Chain_R S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W P W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S G I R V G S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M A I S P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

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Download 7XAV_nogp.zip

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