psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	6.72	No	No	0	0	0
2	L:L:?1	L:L:T8	5	No	No	0	0	0
3	L:L:C2	L:L:C7	7.28	No	No	1	0	0
4	L:L:C2	R:R:F294	9.78	No	Yes	1	0	4
5	L:L:?4	L:L:F3	5.8	Yes	Yes	1	0	0
6	L:L:F3	R:R:I195	3.77	Yes	Yes	0	0	5
7	L:L:F3	R:R:Y205	23.73	Yes	Yes	1	0	4
8	L:L:F3	R:R:I209	3.77	Yes	Yes	1	0	5
9	L:L:?4	L:L:K5	12.31	Yes	No	0	0	0
10	L:L:?4	R:R:F272	3.87	Yes	Yes	1	0	6
11	L:L:?4	R:R:N276	4.36	Yes	No	1	0	6
12	L:L:?4	R:R:F294	2.9	Yes	Yes	1	0	4
13	L:L:K5	R:R:Q126	4.07	No	No	0	0	7
14	L:L:C7	R:R:K291	4.85	No	No	0	0	3
15	L:L:C7	R:R:F294	5.59	No	Yes	1	0	4
16	L:L:T8	R:R:N186	4.39	No	No	0	0	1
17	R:R:N43	R:R:S42	4.47	No	No	0	3	4
18	R:R:I49	R:R:V45	3.07	No	No	0	5	5
19	R:R:D295	R:R:L46	8.14	No	No	0	2	5
20	R:R:F48	R:R:V52	6.55	No	No	0	6	5
21	R:R:I49	R:R:V299	6.14	No	No	0	5	5
22	R:R:L96	R:R:Y50	5.86	Yes	Yes	0	7	7
23	R:R:A100	R:R:Y50	4	No	Yes	0	6	7
24	R:R:V299	R:R:Y50	6.31	No	Yes	0	5	7
25	R:R:C54	R:R:L58	3.17	No	No	0	6	6
26	R:R:C54	R:R:L96	7.94	No	Yes	0	6	7
27	R:R:G57	R:R:I56	3.53	No	No	3	8	4
28	R:R:C306	R:R:I56	3.27	No	No	3	8	4
29	R:R:C306	R:R:G57	3.92	No	No	3	8	8
30	R:R:G60	R:R:L63	3.42	No	No	0	8	6
31	R:R:D89	R:R:N61	12.12	No	No	4	9	9
32	R:R:E90	R:R:N61	7.89	No	No	0	7	9
33	R:R:N61	R:R:P309	4.89	No	No	4	9	9
34	R:R:E90	R:R:T62	4.23	No	No	0	7	5
35	R:R:I65	R:R:L83	2.85	No	Yes	2	7	6
36	R:R:I65	R:R:I87	2.94	No	No	2	7	7
37	R:R:E90	R:R:I65	5.47	No	No	0	7	7
38	R:R:R70	R:R:Y66	10.29	No	No	0	4	3
39	R:R:F319	R:R:V67	5.24	No	No	0	8	7
40	R:R:F323	R:R:V67	13.11	No	No	0	6	7
41	R:R:A72	R:R:I68	3.25	No	Yes	0	5	7
42	R:R:I68	R:R:M74	2.92	Yes	Yes	2	7	7
43	R:R:I68	R:R:N79	5.66	Yes	No	2	7	8
44	R:R:I68	R:R:L83	4.28	Yes	Yes	2	7	6
45	R:R:R70	R:R:Y71	9.26	No	No	0	4	6
46	R:R:N325	R:R:Y71	6.98	No	No	0	4	6
47	R:R:V326	R:R:Y71	15.14	No	No	0	5	6
48	R:R:M74	R:R:N79	2.8	Yes	No	2	7	8
49	R:R:I80	R:R:M74	2.92	No	Yes	0	5	7
50	R:R:L83	R:R:M74	9.9	Yes	Yes	2	6	7
51	R:R:K75	R:R:T76	3	No	No	0	7	7
52	R:R:N79	R:R:T76	7.31	No	No	0	8	7
53	R:R:I77	R:R:P156	3.39	No	No	0	4	3
54	R:R:I82	R:R:T78	3.04	No	No	0	8	8
55	R:R:M136	R:R:Y81	2.39	No	No	0	9	7
56	R:R:D139	R:R:Y81	8.05	No	No	0	8	7
57	R:R:I162	R:R:Y81	2.42	No	No	0	5	7
58	R:R:I87	R:R:L83	2.85	No	Yes	2	7	6
59	R:R:N84	R:R:T163	2.92	No	No	0	9	7
60	R:R:N84	R:R:W167	5.65	No	Yes	0	9	9
61	R:R:L85	R:R:N308	5.49	No	No	0	9	9
62	R:R:D89	R:R:S305	10.31	No	No	0	9	8
63	R:R:D89	R:R:P309	3.22	No	No	4	9	9
64	R:R:L91	R:R:L94	5.54	No	No	0	7	5
65	R:R:L91	R:R:N125	2.75	No	No	0	7	7
66	R:R:F92	R:R:N125	6.04	No	No	0	6	7
67	R:R:F92	R:R:Y302	13.41	No	No	0	6	7
68	R:R:L96	R:R:M93	2.83	Yes	No	0	7	6
69	R:R:M93	R:R:S305	4.6	No	No	0	6	8
70	R:R:L96	R:R:Y302	7.03	Yes	No	0	7	7
71	R:R:F110	R:R:F98	5.36	Yes	No	0	6	5
72	R:R:F98	R:R:V118	2.62	No	No	0	5	5
73	R:R:L105	R:R:M101	5.65	No	No	0	5	5
74	R:R:F110	R:R:M101	9.95	Yes	No	0	6	5
75	R:R:Q102	R:R:W108	9.86	No	Yes	0	5	8
76	R:R:Q102	R:R:S192	2.89	No	No	0	5	4
77	R:R:D295	R:R:V103	5.84	No	No	0	2	4
78	R:R:H107	R:R:L105	11.57	No	No	0	4	5
79	R:R:H107	R:R:P109	18.3	No	No	0	4	4
80	R:R:H107	R:R:R190	15.8	No	No	0	4	1
81	R:R:P109	R:R:W108	2.7	No	Yes	0	4	8
82	R:R:F110	R:R:W108	19.04	Yes	Yes	5	6	8
83	R:R:G111	R:R:W108	2.81	No	Yes	0	7	8
84	R:R:I114	R:R:W108	7.05	Yes	Yes	5	6	8
85	R:R:C115	R:R:W108	7.84	No	Yes	0	9	8
86	R:R:F110	R:R:I114	3.77	Yes	Yes	5	6	6
87	R:R:K112	R:R:L183	8.46	No	No	0	3	4
88	R:R:I114	R:R:V118	3.07	Yes	No	0	6	5
89	R:R:C115	R:R:C193	7.28	No	No	0	9	9
90	R:R:R116	R:R:V117	2.62	No	No	0	6	5
91	R:R:M178	R:R:R116	7.44	No	No	0	5	6
92	R:R:M178	R:R:T120	3.01	No	No	0	5	6
93	R:R:G123	R:R:I174	3.53	No	No	0	4	7
94	R:R:I124	R:R:N125	4.25	Yes	No	0	5	7
95	R:R:I124	R:R:W167	2.35	Yes	Yes	0	5	9
96	R:R:I124	R:R:L171	2.85	Yes	No	0	5	3
97	R:R:I124	R:R:I174	2.94	Yes	No	0	5	7
98	R:R:F127	R:R:Q126	3.51	No	No	0	6	7
99	R:R:Q126	R:R:W269	5.48	No	Yes	0	7	8
100	R:R:F127	R:R:F131	3.22	No	No	0	6	6
101	R:R:F127	R:R:V173	2.62	No	Yes	0	6	4
102	R:R:T128	R:R:W167	12.13	No	Yes	0	7	9
103	R:R:I130	R:R:P220	3.39	No	No	0	8	9
104	R:R:I130	R:R:W269	3.52	No	Yes	0	8	8
105	R:R:F131	R:R:V166	2.62	No	No	0	6	6
106	R:R:I224	R:R:L133	2.85	No	No	0	7	9
107	R:R:L133	R:R:Y312	5.86	No	Yes	0	9	9
108	R:R:M136	R:R:Y312	4.79	No	Yes	0	9	9
109	R:R:S137	R:R:Y228	2.54	No	No	0	9	9
110	R:R:I138	R:R:I223	5.89	No	No	0	6	6
111	R:R:D139	R:R:R154	7.15	No	No	0	8	5
112	R:R:R140	R:R:Y228	5.14	No	No	0	9	9
113	R:R:L142	R:R:Y141	3.52	No	Yes	0	4	8
114	R:R:V145	R:R:Y141	15.14	No	Yes	0	7	8
115	R:R:C227	R:R:Y141	8.06	No	Yes	0	7	8
116	R:R:F230	R:R:Y141	6.19	No	Yes	0	4	8
117	R:R:A143	R:R:R154	2.77	No	No	0	8	5
118	R:R:H146	R:R:V145	11.07	No	No	0	5	7
119	R:R:H146	R:R:K149	7.86	No	No	0	5	4
120	R:R:R154	R:R:S150	5.27	No	No	0	5	5
121	R:R:K152	R:R:W153	5.8	No	No	0	4	3
122	R:R:P156	R:R:R155	7.21	No	No	0	3	6
123	R:R:K160	R:R:T163	6.01	No	No	0	1	7
124	R:R:V166	R:R:W167	3.68	No	Yes	0	6	9
125	R:R:V173	R:R:Y211	2.52	Yes	No	6	4	4
126	R:R:L215	R:R:V173	2.98	No	Yes	6	4	4
127	R:R:L175	R:R:P176	3.28	No	No	0	4	8
128	R:R:I179	R:R:P176	3.39	No	No	0	4	8
129	R:R:I177	R:R:I195	5.89	No	Yes	0	3	5
130	R:R:N196	R:R:Y180	9.3	No	No	0	3	4
131	R:R:W197	R:R:Y180	9.65	Yes	No	0	5	4
132	R:R:G182	R:R:W197	4.22	No	Yes	0	5	5
133	R:R:L183	R:R:S191	6.01	No	No	0	4	5
134	R:R:C193	R:R:L183	4.76	No	No	0	9	4
135	R:R:R184	R:R:W197	8	No	Yes	0	2	5
136	R:R:N186	R:R:S192	7.45	No	No	0	1	4
137	R:R:T194	R:R:W197	4.85	No	Yes	0	4	5
138	R:R:I195	R:R:N196	2.83	Yes	No	0	5	3
139	R:R:F208	R:R:I195	5.02	No	Yes	0	7	5
140	R:R:N196	R:R:W204	12.43	No	No	0	3	3
141	R:R:I209	R:R:Y205	4.84	Yes	Yes	1	5	4
142	R:R:V280	R:R:Y205	13.88	No	Yes	0	4	4
143	R:R:T206	R:R:V280	3.17	No	No	0	3	4
144	R:R:G207	R:R:I210	3.53	No	No	0	4	5
145	R:R:F208	R:R:I209	3.77	No	Yes	1	7	5
146	R:R:F208	R:R:T212	3.89	No	No	1	7	4
147	R:R:I209	R:R:T212	3.04	Yes	No	1	5	4
148	R:R:L215	R:R:Y211	3.52	No	No	6	4	4
149	R:R:F213	R:R:F217	5.36	No	Yes	1	5	8
150	R:R:F213	R:R:Y273	9.28	No	No	1	5	7
151	R:R:I214	R:R:L218	8.56	No	No	0	4	4
152	R:R:F217	R:R:W269	5.01	Yes	Yes	0	8	8
153	R:R:F217	R:R:Y273	7.22	Yes	No	1	8	7
154	R:R:P220	R:R:V219	5.3	No	No	0	9	5
155	R:R:I266	R:R:L221	5.71	No	No	0	6	6
156	R:R:C225	R:R:V262	3.42	No	No	0	5	7
157	R:R:V258	R:R:Y228	10.09	No	No	0	8	9
158	R:R:I232	R:R:V254	4.61	No	No	0	5	8
159	R:R:E251	R:R:K236	4.05	No	No	0	6	4
160	R:R:E251	R:R:S250	4.31	No	No	0	6	5
161	R:R:K253	R:R:R256	4.95	No	No	0	7	6
162	R:R:V261	R:R:Y312	2.52	No	Yes	0	8	9
163	R:R:A263	R:R:F267	2.77	No	No	0	5	6
164	R:R:F265	R:R:W269	10.02	No	Yes	0	9	8
165	R:R:F265	R:R:N304	2.42	No	No	0	9	9
166	R:R:F267	R:R:I266	3.77	No	No	0	6	6
167	R:R:C268	R:R:N304	3.15	No	No	0	8	9
168	R:R:T301	R:R:W269	3.64	No	Yes	0	7	8
169	R:R:I274	R:R:L270	7.14	No	No	0	5	5
170	R:R:F272	R:R:Y273	8.25	Yes	No	1	6	7
171	R:R:F272	R:R:N276	4.83	Yes	No	1	6	6
172	R:R:F272	R:R:V297	3.93	Yes	No	0	6	7
173	R:R:F272	R:R:T301	3.89	Yes	No	0	6	7
174	R:R:F275	R:R:L290	2.44	Yes	No	0	4	4
175	R:R:F275	R:R:M293	4.98	Yes	No	0	4	4
176	R:R:F275	R:R:F294	4.29	Yes	Yes	0	4	4
177	R:R:F294	R:R:N276	4.83	Yes	No	1	4	6
178	R:R:M282	R:R:S281	6.13	No	No	0	3	4
179	R:R:L290	R:R:T287	4.42	No	No	0	4	1
180	R:R:N304	R:R:N308	4.09	No	No	0	9	9
181	R:R:N308	R:R:Y312	11.63	No	Yes	0	9	9
182	R:R:F314	R:R:I310	6.28	No	No	0	7	6
183	R:R:L311	R:R:Y312	3.52	No	Yes	0	8	9
184	R:R:F314	R:R:F319	5.36	No	No	0	7	8
185	R:R:F323	R:R:V326	2.62	No	No	0	6	5
186	R:R:L46	R:R:Y50	2.34	No	Yes	0	5	7
187	R:R:G95	R:R:P97	2.03	No	No	0	6	8
188	R:R:C59	R:R:G60	1.96	No	No	0	5	8
189	R:R:G207	R:R:T206	1.82	No	No	0	4	3
190	R:R:A303	R:R:C268	1.81	No	No	0	5	8
191	R:R:P309	R:R:V64	1.77	No	No	0	9	9
192	R:R:G57	R:R:M93	1.75	No	No	0	8	6
193	R:R:P220	R:R:T134	1.75	No	No	0	9	7
194	R:R:P288	R:R:T287	1.75	No	No	0	3	1
195	R:R:G292	R:R:K291	1.74	No	No	0	1	3
196	R:R:G95	R:R:L94	1.71	No	No	0	6	5
197	R:R:C132	R:R:V166	1.71	No	No	0	8	6
198	R:R:C268	R:R:V264	1.71	No	No	0	8	7
199	R:R:A44	R:R:T47	1.68	No	No	0	4	5
200	R:R:A104	R:R:T47	1.68	No	No	0	5	5
201	R:R:A88	R:R:T128	1.68	No	No	0	8	7
202	R:R:D122	R:R:G123	1.68	No	No	0	6	4
203	R:R:A289	R:R:T287	1.68	No	No	0	1	1
204	R:R:C59	R:R:I55	1.64	No	No	0	5	4
205	R:R:C227	R:R:I138	1.64	No	No	0	7	6
206	R:R:L270	R:R:P271	1.64	No	No	0	5	9
207	R:R:A159	R:R:I77	1.62	No	No	0	7	4
208	R:R:A159	R:R:I80	1.62	No	No	0	7	5
209	R:R:A165	R:R:I162	1.62	No	No	0	4	5
210	R:R:S259	R:R:V258	1.62	No	No	0	4	8
211	R:R:S42	R:R:T41	1.6	No	No	0	4	4
212	R:R:V169	R:R:V173	1.6	No	Yes	0	4	4
213	R:R:V258	R:R:V262	1.6	No	No	0	8	7
214	R:R:V277	R:R:V280	1.6	No	No	0	5	4
215	R:R:C225	R:R:L221	1.59	No	No	0	5	6
216	R:R:T255	R:R:V254	1.59	No	No	0	7	8
217	R:R:T301	R:R:V298	1.59	No	No	0	7	6
218	L:L:T6	R:R:T194	1.57	No	No	0	0	4
219	R:R:T76	R:R:T78	1.57	No	No	0	7	8
220	R:R:I124	R:R:S170	1.55	Yes	No	0	5	7
221	R:R:I224	R:R:S137	1.55	No	No	0	7	9
222	R:R:I49	R:R:V53	1.54	No	No	0	5	7
223	R:R:I56	R:R:V53	1.54	No	No	0	4	7
224	R:R:I114	R:R:V117	1.54	Yes	No	0	6	5
225	R:R:I260	R:R:V261	1.54	No	No	0	6	8
226	R:R:I260	R:R:V264	1.54	No	No	0	6	7
227	R:R:H146	R:R:P147	1.53	No	No	0	5	8
228	R:R:M282	R:R:S278	1.53	No	No	0	3	4
229	R:R:M119	R:R:V118	1.52	No	No	0	5	5
230	R:R:I223	R:R:T134	1.52	No	No	0	6	7
231	R:R:K234	R:R:V145	1.52	No	No	0	5	7
232	R:R:I223	R:R:T222	1.52	No	No	0	6	4
233	R:R:F217	R:R:G216	1.51	Yes	No	0	8	6
234	R:R:D122	R:R:V121	1.46	No	No	0	6	5
235	R:R:I162	R:R:M161	1.46	No	No	0	5	1
236	R:R:I179	R:R:M178	1.46	No	No	0	4	5
237	R:R:I68	R:R:L69	1.43	Yes	No	0	7	3
238	R:R:I214	R:R:L215	1.43	No	No	0	4	4
239	R:R:I266	R:R:L270	1.43	No	No	0	6	5
240	R:R:G168	R:R:W167	1.41	No	Yes	0	4	9
241	R:R:A100	R:R:F51	1.39	No	No	0	6	5
242	R:R:A181	R:R:R116	1.38	No	No	0	4	6
243	R:R:K321	R:R:Q324	1.36	No	No	0	5	4
244	R:R:F275	R:R:S278	1.32	Yes	No	0	4	4
245	R:R:N325	R:R:Q324	1.32	No	No	0	4	4
246	R:R:R155	R:R:T158	1.29	No	No	0	6	5
247	L:L:?1	R:R:S279	1.27	No	No	0	0	4
248	R:R:S279	R:R:Y205	1.27	No	Yes	0	4	4
249	R:R:F230	R:R:I233	1.26	No	No	0	4	3
250	R:R:I231	R:R:R140	1.25	No	No	0	9	9
251	R:R:F296	R:R:M293	1.24	No	No	0	5	4
252	R:R:F98	R:R:L99	1.22	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F3	9.2675	4	1	0
2	L:L:?4	5.848	5	1	0
3	R:R:Y50	4.6275	4	0	7
4	R:R:I68	3.508	5	2	7
5	R:R:M74	4.635	4	2	7
6	R:R:L83	4.97	4	2	6
7	R:R:L96	5.915	4	0	7
8	R:R:W108	8.21667	6	5	8
9	R:R:F110	9.53	4	5	6
10	R:R:I114	3.8575	4	5	6
11	R:R:I124	2.788	5	0	5
12	R:R:Y141	8.2275	4	0	8
13	R:R:W167	5.044	5	0	9
14	R:R:V173	2.43	4	6	4
15	R:R:I195	4.3775	4	0	5
16	R:R:W197	6.68	4	0	5
17	R:R:Y205	10.93	4	1	4
18	R:R:I209	3.855	4	1	5
19	R:R:F217	4.775	4	1	8
20	R:R:W269	5.534	5	0	8
21	R:R:F272	4.954	5	1	6
22	R:R:F275	3.2575	4	0	4
23	R:R:F294	5.478	5	1	4
24	R:R:Y312	5.664	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:C2	82.2202	6.72	No	No	0	0	0
2	L:L:C2	R:R:F294	83.432	9.78	No	Yes	1	0	4
3	L:L:?4	R:R:F294	88.4736	2.9	Yes	Yes	1	0	4
4	L:L:F3	R:R:Y205	17.4376	23.73	Yes	Yes	1	0	4
5	L:L:F3	R:R:I195	24.7364	3.77	Yes	Yes	0	0	5
6	L:L:?4	L:L:K5	88.8067	12.31	Yes	No	0	0	0
7	L:L:?4	R:R:F272	41.1841	3.87	Yes	Yes	1	0	6
8	R:R:F294	R:R:N276	27.3728	4.83	Yes	No	1	4	6
9	R:R:F272	R:R:N276	27.5578	4.83	Yes	No	1	6	6
10	L:L:K5	R:R:Q126	89.2599	4.07	No	No	0	0	7
11	L:L:?1	L:L:T8	85.5134	5	No	No	0	0	0
12	L:L:T8	R:R:N186	83.0065	4.39	No	No	0	0	1
13	R:R:F127	R:R:Q126	100	3.51	No	No	0	6	7
14	R:R:F127	R:R:F131	96.0222	3.22	No	No	0	6	6
15	R:R:F131	R:R:V166	95.3377	2.62	No	No	0	6	6
16	R:R:V166	R:R:W167	93.913	3.68	No	Yes	0	6	9
17	R:R:I124	R:R:W167	88.3441	2.35	Yes	Yes	0	5	9
18	R:R:I124	R:R:N125	81.8686	4.25	Yes	No	0	5	7
19	R:R:F92	R:R:N125	76.6883	6.04	No	No	0	6	7
20	R:R:F92	R:R:Y302	75.5967	13.41	No	No	0	6	7
21	R:R:L96	R:R:Y302	74.4866	7.03	Yes	No	0	7	7
22	R:R:L96	R:R:Y50	18.6586	5.86	Yes	Yes	0	7	7
23	R:R:L96	R:R:M93	57.8908	2.83	Yes	No	0	7	6
24	R:R:M93	R:R:S305	51.6189	4.6	No	No	0	6	8
25	R:R:D89	R:R:S305	50.148	10.31	No	No	0	9	8
26	R:R:D89	R:R:N61	45.1434	12.12	No	No	4	9	9
27	R:R:E90	R:R:N61	44.0796	7.89	No	No	0	7	9
28	R:R:E90	R:R:I65	40.9066	5.47	No	No	0	7	7
29	R:R:I65	R:R:L83	37.4653	2.85	No	Yes	2	7	6
30	R:R:I68	R:R:L83	14.6253	4.28	Yes	Yes	2	7	6
31	R:R:L83	R:R:M74	21.5634	9.9	Yes	Yes	2	6	7
32	R:R:I80	R:R:M74	11.2766	2.92	No	Yes	0	5	7
33	R:R:N79	R:R:T76	15.0509	7.31	No	No	0	8	7
34	R:R:Q126	R:R:W269	81.6281	5.48	No	Yes	0	7	8
35	R:R:F265	R:R:W269	99.0564	10.02	No	Yes	0	9	8
36	R:R:F265	R:R:N304	96.6605	2.42	No	No	0	9	9
37	R:R:N304	R:R:N308	83.8298	4.09	No	No	0	9	9
38	R:R:N308	R:R:Y312	78.8344	11.63	No	Yes	0	9	9
39	R:R:M136	R:R:Y312	25.4117	4.79	No	Yes	0	9	9
40	R:R:F272	R:R:T301	63.5523	3.89	Yes	No	0	6	7
41	R:R:T301	R:R:W269	63.8483	3.64	No	Yes	0	7	8
42	R:R:M136	R:R:Y81	22.7475	2.39	No	No	0	9	7
43	R:R:D139	R:R:Y81	11.4524	8.05	No	No	0	8	7
44	R:R:N186	R:R:S192	80.481	7.45	No	No	0	1	4
45	R:R:Q102	R:R:S192	77.9371	2.89	No	No	0	5	4
46	R:R:Q102	R:R:W108	75.7724	9.86	No	Yes	0	5	8
47	R:R:F110	R:R:W108	14.5143	19.04	Yes	Yes	5	6	8
48	R:R:I114	R:R:W108	32.0444	7.05	Yes	Yes	5	6	8
49	R:R:P109	R:R:W108	11.9334	2.7	No	Yes	0	4	8
50	R:R:C115	R:R:W108	14.7179	7.84	No	Yes	0	9	8
51	R:R:C115	R:R:C193	12.1277	7.28	No	No	0	9	9
52	R:R:I114	R:R:V117	24.0426	1.54	Yes	No	0	6	5
53	R:R:R116	R:R:V117	21.1008	2.62	No	No	0	6	5
54	R:R:M178	R:R:R116	15.1619	7.44	No	No	0	5	6
55	R:R:F127	R:R:V173	11.2951	2.62	No	Yes	0	6	4
56	R:R:I130	R:R:W269	49.0749	3.52	No	Yes	0	8	8
57	R:R:I130	R:R:P220	46.4477	3.39	No	No	0	8	9
58	R:R:L133	R:R:Y312	48.8344	5.86	No	Yes	0	9	9
59	R:R:I224	R:R:L133	46.2165	2.85	No	No	0	7	9
60	R:R:I224	R:R:S137	43.654	1.55	No	No	0	7	9
61	R:R:S137	R:R:Y228	40.8326	2.54	No	No	0	9	9
62	R:R:P220	R:R:T134	40.8603	1.75	No	No	0	9	7
63	R:R:I223	R:R:T134	38.0389	1.52	No	No	0	6	7
64	R:R:I138	R:R:I223	32.3312	5.89	No	No	0	6	6
65	R:R:C227	R:R:I138	29.4542	1.64	No	No	0	7	6
66	R:R:C227	R:R:Y141	26.568	8.06	No	Yes	0	7	8
67	R:R:V145	R:R:Y141	14.7919	15.14	No	Yes	0	7	8
68	R:R:I195	R:R:N196	18.8807	2.83	Yes	No	0	5	3
69	R:R:N196	R:R:Y180	14.4218	9.3	No	No	0	3	4
70	R:R:W197	R:R:Y180	12.0259	9.65	Yes	No	0	5	4
71	R:R:V280	R:R:Y205	12.3404	13.88	No	Yes	0	4	4
72	R:R:V258	R:R:Y228	32.3034	10.09	No	No	0	8	9
73	R:R:V258	R:R:V262	26.8733	1.6	No	No	0	8	7
74	R:R:C225	R:R:V262	23.95	3.42	No	No	0	5	7
75	R:R:C225	R:R:L221	21.0268	1.59	No	No	0	5	6
76	R:R:I266	R:R:L221	18.0759	5.71	No	No	0	6	6
77	R:R:C268	R:R:N304	11.5541	3.15	No	No	0	8	9
78	R:R:F275	R:R:F294	29.593	4.29	Yes	Yes	0	4	4
79	R:R:F275	R:R:L290	12.1462	2.44	Yes	No	0	4	4
80	L:L:?4	L:L:F3	42.3127	5.8	Yes	Yes	1	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C2	R:R:F294	9.78	1	No	Yes	0	4	0	1
L:L:F3	R:R:I195	3.77	1	Yes	Yes	0	5	0	1
L:L:F3	R:R:Y205	23.73	1	Yes	Yes	0	4	0	1
L:L:F3	R:R:I209	3.77	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:F272	3.87	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N276	4.36	1	Yes	No	0	6	0	1
L:L:?4	R:R:F294	2.9	1	Yes	Yes	0	4	0	1
L:L:K5	R:R:Q126	4.07	0	No	No	0	7	0	1
L:L:C7	R:R:K291	4.85	1	No	No	0	3	0	1
L:L:C7	R:R:F294	5.59	1	No	Yes	0	4	0	1
L:L:T8	R:R:N186	4.39	0	No	No	0	1	0	1
R:R:F127	R:R:Q126	3.51	0	No	No	6	7	2	1
R:R:Q126	R:R:W269	5.48	0	No	Yes	7	8	1	2
R:R:I177	R:R:I195	5.89	0	No	Yes	3	5	2	1
R:R:N186	R:R:S192	7.45	0	No	No	1	4	1	2
R:R:T194	R:R:W197	4.85	0	No	Yes	4	5	1	2
R:R:I195	R:R:N196	2.83	0	Yes	No	5	3	1	2
R:R:F208	R:R:I195	5.02	1	No	Yes	7	5	2	1
R:R:I209	R:R:Y205	4.84	1	Yes	Yes	5	4	1	1
R:R:V280	R:R:Y205	13.88	0	No	Yes	4	4	2	1
R:R:F208	R:R:I209	3.77	1	No	Yes	7	5	2	1
R:R:F208	R:R:T212	3.89	1	No	No	7	4	2	2
R:R:I209	R:R:T212	3.04	1	Yes	No	5	4	1	2
R:R:T301	R:R:W269	3.64	0	No	Yes	7	8	2	2
R:R:F272	R:R:Y273	8.25	1	Yes	No	6	7	1	2
R:R:F272	R:R:N276	4.83	1	Yes	No	6	6	1	1
R:R:F272	R:R:V297	3.93	1	Yes	No	6	7	1	2
R:R:F272	R:R:T301	3.89	1	Yes	No	6	7	1	2
R:R:F275	R:R:F294	4.29	0	Yes	Yes	4	4	2	1
R:R:F294	R:R:N276	4.83	1	Yes	No	4	6	1	1
R:R:G292	R:R:K291	1.74	0	No	No	1	3	2	1
L:L:T6	R:R:T194	1.57	0	No	No	0	4	0	1
L:L:?1	R:R:S279	1.27	0	No	No	0	4	0	1
R:R:S279	R:R:Y205	1.27	0	No	Yes	4	4	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y26_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.35
Number of Linked Nodes	241
Number of Links	252
Number of Hubs	24
Number of Links mediated by Hubs	89
Number of Communities	6
Number of Nodes involved in Communities	32
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	29269
Length Of Smallest Path	3
Average Path Length	16.7216
Length of Longest Path	41
Minimum Path Strength	1.34
Average Path Strength	5.36759
Maximum Path Strength	18.805
Minimum Path Correlation	0.7
Average Path Correlation	0.927545
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	39.3205
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	28.3277
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	6919011
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid DTR D-Tryptophan (R)-tryptophan
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30874
Sequence	>7Y26_nogp_Chain_R T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y A K M K T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L V H W P F G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H P I K S A K W R R P R T A K M I T M A V W G V S L L V I L P I M I Y A G L R S N Q W G R S S C T I N W G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M P T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F K K S F Q N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YAE	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAE (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.37	2023-04-19	10.1038/s41467-023-36673-z
	7YAC	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-	Gi1/β1/γ2	3.24	2023-04-19	10.1038/s41467-023-36673-z
	7YAC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Paltusotine	-		3.24	2023-04-19	10.1038/s41467-023-36673-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7T11	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi3/β1/γ2	2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T11 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.7	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi3/β1/γ2	2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7T10 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.5	2022-03-09	doi.org/10.1038/s41594-022-00727-5
	7XAV	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAV (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Lanreotide	-		2.87	2022-08-31	10.1038/s41421-022-00405-2
	7XAU	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Gi1/β1/γ2	2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAU (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		2.97	2022-08-31	10.1038/s41421-022-00405-2
	7XAT	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XAT (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.85	2022-08-31	10.1038/s41421-022-00405-2
	7XNA	A	Peptide	Somatostatin	SST2	Homo sapiens	CYN154806	-	-	2.65	2022-08-03	10.1038/s41422-022-00679-x
	7XN9	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,522	-	-	2.6	2022-08-03	10.1038/s41422-022-00679-x
	7XMR	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.1	2022-08-03	10.1038/s41422-022-00679-x
	7XMR (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.1	2022-08-03	10.1038/s41422-022-00679-x
	7WJ5	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	3.72	2022-07-13	10.7554/eLife.76823
	7WJ5 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.72	2022-07-13	10.7554/eLife.76823
	7UL5	A	Peptide	Somatostatin	SST2	Homo sapiens	-	-	-	3.1	2022-06-29	10.1038/s41594-022-00859-8
	7WIG	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-	Gi1/β1/γ2	2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIG (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	L-054,264	-		2.7	2022-06-01	10.1038/s41422-022-00669-z
	7WIC	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.8	2022-06-01	10.1038/s41422-022-00669-z
	7WIC (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		2.8	2022-06-01	10.1038/s41422-022-00669-z

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y26_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.