psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T341	R:R:Y45	4.99	No	No	0	5	4
2	R:R:L49	R:R:Y53	4.69	No	Yes	0	5	7
3	R:R:I108	R:R:L49	5.71	No	No	0	5	5
4	R:R:L49	R:R:T341	4.42	No	No	0	5	5
5	R:R:I108	R:R:I50	5.89	No	No	0	5	7
6	R:R:A52	R:R:W345	5.19	No	Yes	0	4	7
7	R:R:L100	R:R:Y53	8.21	Yes	Yes	1	8	7
8	R:R:S103	R:R:Y53	3.82	No	Yes	1	7	7
9	R:R:L104	R:R:Y53	16.41	No	Yes	0	7	7
10	R:R:D107	R:R:Y53	4.6	No	Yes	0	6	7
11	R:R:W345	R:R:Y53	11.58	Yes	Yes	1	7	7
12	R:R:Y348	R:R:Y53	4.96	Yes	Yes	1	7	7
13	R:R:V56	R:R:W345	4.9	No	Yes	0	7	7
14	R:R:F57	R:R:L61	6.09	No	Yes	1	7	6
15	R:R:F57	R:R:T96	3.89	No	No	1	7	7
16	R:R:F57	R:R:L100	6.09	No	Yes	1	7	8
17	R:R:A60	R:R:T96	5.03	No	No	0	8	7
18	R:R:L61	R:R:T96	4.42	Yes	No	1	6	7
19	R:R:G63	R:R:P355	4.06	No	No	0	9	9
20	R:R:N64	R:R:S89	8.94	No	No	0	9	9
21	R:R:D92	R:R:N64	12.12	Yes	No	0	9	9
22	R:R:N64	R:R:P355	9.77	No	No	0	9	9
23	R:R:F369	R:R:L66	3.65	No	Yes	0	7	6
24	R:R:S89	R:R:V67	8.08	No	No	0	9	9
25	R:R:V67	R:R:Y358	5.05	No	Yes	2	9	9
26	R:R:F365	R:R:V67	3.93	Yes	No	2	8	9
27	R:R:V71	R:R:V86	4.81	No	No	0	8	6
28	R:R:Q368	R:R:R73	10.51	No	No	0	7	6
29	R:R:H76	R:R:N74	5.1	No	No	0	5	6
30	R:R:M77	R:R:N74	14.02	Yes	No	0	8	6
31	R:R:N74	R:R:Q368	10.56	No	No	0	6	7
32	R:R:H75	R:R:R78	25.95	No	No	0	6	7
33	R:R:M77	R:R:N82	5.61	Yes	Yes	2	8	9
34	R:R:K364	R:R:M77	7.2	No	Yes	0	6	8
35	R:R:F365	R:R:M77	8.71	Yes	Yes	2	8	8
36	R:R:R78	R:R:Y83	9.26	No	No	0	7	4
37	R:R:N82	R:R:T79	5.85	Yes	No	0	9	7
38	R:R:D143	R:R:V80	11.69	No	No	0	9	6
39	R:R:R144	R:R:T81	3.88	No	No	0	9	8
40	R:R:L300	R:R:T81	4.42	Yes	No	0	8	8
41	R:R:F365	R:R:N82	6.04	Yes	Yes	2	8	9
42	R:R:F84	R:R:T136	3.89	Yes	No	0	8	8
43	R:R:F139	R:R:F84	8.57	No	Yes	0	7	8
44	R:R:F84	R:R:I140	5.02	Yes	No	0	8	8
45	R:R:F84	R:R:S164	3.96	Yes	No	0	8	6
46	R:R:F84	R:R:I165	5.02	Yes	No	0	8	8
47	R:R:L85	R:R:Y358	15.24	No	Yes	0	8	9
48	R:R:N87	R:R:T136	7.31	Yes	No	0	9	8
49	R:R:I165	R:R:N87	15.58	No	Yes	0	8	9
50	R:R:I168	R:R:N87	4.25	Yes	Yes	0	7	9
51	R:R:N87	R:R:W169	9.04	Yes	No	0	9	9
52	R:R:D92	R:R:L88	4.07	Yes	No	2	9	9
53	R:R:L88	R:R:N354	5.49	No	Yes	2	9	9
54	R:R:D92	R:R:S351	11.78	Yes	No	0	9	9
55	R:R:D92	R:R:N354	6.73	Yes	Yes	2	9	9
56	R:R:C99	R:R:Q126	6.1	No	Yes	1	8	8
57	R:R:C99	R:R:Y348	4.03	No	Yes	1	8	7
58	R:R:L100	R:R:P101	4.93	Yes	No	0	8	8
59	R:R:L100	R:R:Y348	11.72	Yes	Yes	1	8	7
60	R:R:S103	R:R:Y348	8.9	No	Yes	1	7	7
61	L:L:?1	R:R:S103	13.07	Yes	No	1	0	7
62	R:R:F114	R:R:L105	6.09	No	No	0	6	5
63	L:L:?1	R:R:V106	3.7	Yes	No	0	0	6
64	R:R:D107	R:R:T341	13.01	No	No	0	6	5
65	R:R:D107	R:R:H344	13.87	No	Yes	0	6	7
66	R:R:S111	R:R:T109	4.8	No	No	6	4	5
67	R:R:L113	R:R:T109	4.42	No	No	6	3	5
68	R:R:E110	R:R:Y337	11.22	No	No	0	4	3
69	R:R:L113	R:R:S111	6.01	No	No	6	3	4
70	R:R:F114	R:R:W112	18.04	No	Yes	0	6	8
71	R:R:C119	R:R:W112	5.22	No	Yes	5	9	8
72	R:R:I122	R:R:W112	4.7	Yes	Yes	0	6	8
73	R:R:C185	R:R:W112	5.22	No	Yes	5	4	8
74	R:R:C202	R:R:W112	14.37	No	Yes	5	9	8
75	R:R:F114	R:R:L118	6.09	No	No	0	6	6
76	R:R:G115	R:R:R197	7.51	No	No	0	8	3
77	R:R:H116	R:R:K120	6.55	No	No	7	4	7
78	R:R:E184	R:R:H116	3.69	No	No	7	5	4
79	R:R:I122	R:R:L118	5.71	Yes	No	0	6	6
80	R:R:C119	R:R:C185	5.46	No	No	5	9	4
81	R:R:C119	R:R:C202	7.28	No	No	5	9	9
82	R:R:E184	R:R:K120	5.4	No	No	7	5	7
83	R:R:M183	R:R:P123	8.39	No	No	0	4	6
84	L:L:?1	R:R:P123	10.21	Yes	No	0	0	6
85	R:R:V128	R:R:Y124	8.83	No	Yes	8	6	6
86	R:R:L173	R:R:Y124	5.86	No	Yes	8	5	6
87	R:R:A180	R:R:Y124	4	No	Yes	0	5	6
88	R:R:Q126	R:R:V130	4.3	Yes	No	1	8	7
89	R:R:Q126	R:R:Y348	6.76	Yes	Yes	1	8	7
90	L:L:?1	R:R:Q126	24.82	Yes	Yes	1	0	8
91	R:R:A127	R:R:M176	6.44	No	Yes	0	6	8
92	R:R:L173	R:R:V128	4.47	No	No	8	5	6
93	R:R:V130	R:R:Y311	6.31	No	No	0	7	8
94	L:L:?1	R:R:V130	3.7	Yes	No	1	0	7
95	R:R:S131	R:R:S172	6.52	No	No	0	8	8
96	R:R:I175	R:R:S131	4.64	No	No	0	6	8
97	R:R:M176	R:R:S131	4.6	Yes	No	0	8	8
98	R:R:I168	R:R:V132	4.61	Yes	Yes	0	7	7
99	R:R:V132	R:R:W169	17.16	Yes	No	0	7	9
100	R:R:S172	R:R:V132	4.85	No	Yes	0	8	7
101	R:R:F307	R:R:V134	5.24	Yes	No	0	9	8
102	R:R:I168	R:R:L135	5.71	Yes	No	0	7	7
103	R:R:F307	R:R:L137	6.09	Yes	No	0	9	9
104	R:R:M231	R:R:S138	4.6	Yes	No	0	8	7
105	R:R:F139	R:R:I168	8.79	No	Yes	0	7	7
106	R:R:I140	R:R:L300	4.28	No	Yes	0	8	8
107	R:R:A141	R:R:Y235	4	No	Yes	0	9	8
108	R:R:L142	R:R:Y146	4.69	No	Yes	0	6	5
109	R:R:D143	R:R:R144	9.53	No	No	0	9	9
110	R:R:D143	R:R:S156	4.42	No	No	0	9	5
111	R:R:A147	R:R:R144	5.53	No	No	0	8	9
112	R:R:W145	R:R:Y146	10.61	Yes	Yes	0	8	5
113	R:R:C149	R:R:W145	5.22	No	Yes	9	7	8
114	R:R:H150	R:R:W145	14.81	No	Yes	9	6	8
115	R:R:Q237	R:R:W145	8.76	No	Yes	0	5	8
116	R:R:F154	R:R:Y146	12.38	No	Yes	0	7	5
117	R:R:I148	R:R:L242	4.28	Yes	No	0	9	8
118	R:R:I148	R:R:R293	10.02	Yes	No	0	9	8
119	R:R:C149	R:R:H150	4.42	No	No	9	7	6
120	R:R:K155	R:R:R160	3.71	No	No	0	6	7
121	R:R:R160	R:R:T157	14.23	No	No	0	7	8
122	R:R:F219	R:R:M176	3.73	Yes	Yes	0	6	8
123	R:R:E204	R:R:Q179	6.37	Yes	No	0	5	7
124	R:R:Q179	R:R:Y215	10.15	No	Yes	0	7	7
125	R:R:E204	R:R:V182	5.7	Yes	No	3	5	6
126	R:R:V182	R:R:W206	9.81	No	Yes	3	6	7
127	R:R:E184	R:R:R205	8.14	No	No	0	5	4
128	R:R:R205	R:R:S186	7.91	No	No	0	4	2
129	R:R:L192	R:R:S187	6.01	No	Yes	0	2	5
130	R:R:F199	R:R:L192	6.09	No	No	0	3	2
131	R:R:A198	R:R:T196	5.03	No	No	0	4	3
132	R:R:A198	R:R:F199	5.55	No	No	0	4	3
133	R:R:D203	R:R:R322	10.72	No	Yes	0	5	6
134	R:R:E204	R:R:W206	9.81	Yes	Yes	3	5	7
135	R:R:E204	R:R:H216	9.85	Yes	No	3	5	6
136	R:R:E204	R:R:R322	19.77	Yes	Yes	3	5	6
137	R:R:P212	R:R:W206	24.32	No	Yes	0	5	7
138	R:R:W206	R:R:Y215	6.75	Yes	Yes	0	7	7
139	R:R:A211	R:R:D208	4.63	No	No	0	4	4
140	R:R:I214	R:R:L210	5.71	No	No	0	4	3
141	R:R:H216	R:R:Y215	7.62	No	Yes	0	6	7
142	R:R:F219	R:R:Y215	5.16	Yes	Yes	0	6	7
143	R:R:H216	R:R:R322	20.31	No	Yes	3	6	6
144	R:R:S217	R:R:V323	4.85	No	No	0	6	5
145	R:R:F219	R:R:T223	14.27	Yes	No	0	6	6
146	L:L:?1	R:R:F219	4.54	Yes	Yes	0	0	6
147	R:R:F220	R:R:Y224	8.25	No	Yes	0	6	8
148	R:R:F220	R:R:L225	6.09	No	No	0	6	6
149	R:R:F220	R:R:V319	5.24	No	No	0	6	6
150	R:R:L228	R:R:Y224	8.21	Yes	Yes	0	6	8
151	R:R:L312	R:R:Y224	7.03	No	Yes	0	6	8
152	R:R:S315	R:R:Y224	8.9	No	Yes	0	7	8
153	R:R:F307	R:R:L228	4.87	Yes	Yes	0	9	6
154	R:R:M231	R:R:V304	4.56	Yes	No	0	8	8
155	R:R:I238	R:R:Y235	4.84	No	Yes	0	9	8
156	R:R:L300	R:R:Y235	8.21	Yes	Yes	0	8	8
157	R:R:M301	R:R:Y235	7.18	No	Yes	0	6	8
158	R:R:F236	R:R:R240	13.9	No	No	0	3	5
159	R:R:F239	R:R:W243	12.03	No	Yes	0	6	6
160	R:R:L242	R:R:W243	4.56	No	Yes	0	8	6
161	R:R:R294	R:R:W243	27.99	No	Yes	0	6	6
162	R:R:Q246	R:R:T250	5.67	No	No	0	5	3
163	R:R:M290	R:R:Q246	13.59	No	No	0	5	5
164	R:R:E286	R:R:T250	7.06	No	No	0	4	3
165	R:R:E286	R:R:T251	11.29	No	No	0	4	4
166	R:R:Q289	R:R:R293	17.52	No	No	0	6	8
167	R:R:M290	R:R:R294	4.96	No	No	0	5	6
168	R:R:K298	R:R:L361	4.23	No	No	0	7	7
169	R:R:M299	R:R:Y358	4.79	No	Yes	0	8	9
170	R:R:L361	R:R:M299	7.07	No	No	0	7	8
171	R:R:M299	R:R:S362	4.6	No	No	0	8	8
172	R:R:I357	R:R:V302	6.14	No	No	0	8	7
173	R:R:L361	R:R:V302	4.47	No	No	0	7	7
174	R:R:N354	R:R:V303	5.91	Yes	No	0	9	8
175	R:R:I357	R:R:V303	4.61	No	No	0	8	8
176	R:R:I357	R:R:V306	4.61	No	No	0	8	6
177	R:R:F307	R:R:Y311	21.66	Yes	No	0	9	8
178	R:R:F307	R:R:N350	4.83	Yes	No	0	9	9
179	R:R:C310	R:R:N350	9.45	No	No	0	8	9
180	R:R:V347	R:R:Y311	10.09	No	No	0	7	8
181	R:R:I314	R:R:S343	7.74	Yes	No	1	7	6
182	R:R:H344	R:R:I314	3.98	Yes	Yes	1	7	7
183	R:R:I314	R:R:V347	4.61	Yes	No	1	7	7
184	L:L:?1	R:R:I314	17.74	Yes	Yes	1	0	7
185	R:R:F327	R:R:L317	3.65	Yes	No	4	3	5
186	R:R:F340	R:R:L317	17.05	No	No	4	5	5
187	R:R:V319	R:R:V323	6.41	No	No	0	6	5
188	R:R:L320	R:R:M326	8.48	No	No	4	5	1
189	R:R:F327	R:R:L320	3.65	Yes	No	4	3	5
190	R:R:K321	R:R:R322	8.66	No	Yes	0	5	6
191	R:R:F327	R:R:K321	3.72	Yes	No	0	3	5
192	R:R:F324	R:R:V323	6.55	No	No	0	4	5
193	R:R:G325	R:R:R328	7.51	No	No	0	2	4
194	R:R:F327	R:R:M326	7.46	Yes	No	4	3	1
195	R:R:F327	R:R:V336	7.87	Yes	No	0	3	4
196	R:R:F327	R:R:F340	5.36	Yes	No	4	3	5
197	R:R:D332	R:R:S331	4.42	No	No	0	3	5
198	R:R:R333	R:R:Y337	12.35	No	No	0	5	3
199	R:R:F342	R:R:W345	4.01	No	Yes	1	6	7
200	R:R:F342	R:R:L346	7.31	No	No	1	6	7
201	R:R:H344	R:R:S343	4.18	Yes	No	1	7	6
202	L:L:?1	R:R:H344	31.17	Yes	Yes	1	0	7
203	R:R:L346	R:R:W345	5.69	No	Yes	1	7	7
204	R:R:A349	R:R:W345	7.78	No	Yes	0	5	7
205	L:L:?1	R:R:V347	3.7	Yes	No	1	0	7
206	L:L:?1	R:R:Y348	4.37	Yes	Yes	1	0	7
207	R:R:N350	R:R:N354	6.81	No	Yes	0	9	9
208	R:R:N354	R:R:Y358	5.81	Yes	Yes	2	9	9
209	R:R:F365	R:R:Y358	10.32	Yes	Yes	2	8	9
210	R:R:F360	R:R:N359	7.25	No	No	0	5	7
211	R:R:N359	R:R:R366	3.62	No	No	0	7	9
212	R:R:F369	R:R:N359	8.46	No	No	0	7	7
213	R:R:F365	R:R:S362	9.25	Yes	No	0	8	8
214	R:R:G363	R:R:R366	6	No	No	0	6	9
215	R:R:F365	R:R:F369	5.36	Yes	No	0	8	7
216	R:R:W375	R:R:W376	5.62	No	No	0	9	3
217	R:R:P227	R:R:V134	3.53	No	No	0	9	8
218	R:R:L125	R:R:Y124	3.52	No	Yes	0	6	6
219	R:R:L153	R:R:Y146	3.52	No	Yes	0	5	5
220	R:R:C68	R:R:V86	3.42	No	No	0	7	6
221	R:R:A95	R:R:S129	3.42	No	No	0	8	7
222	R:R:A352	R:R:V59	3.39	No	No	0	7	5
223	R:R:A161	R:R:V80	3.39	No	No	0	7	6
224	R:R:A91	R:R:V132	3.39	No	Yes	0	8	7
225	R:R:I122	R:R:P123	3.39	Yes	No	0	6	6
226	R:R:I247	R:R:P248	3.39	No	No	0	5	3
227	R:R:L152	R:R:P151	3.28	No	No	0	7	9
228	R:R:L312	R:R:P313	3.28	No	No	0	6	9
229	R:R:L346	R:R:P313	3.28	No	No	0	7	9
230	R:R:C99	R:R:I98	3.27	No	No	0	8	5
231	R:R:S187	R:R:S200	3.26	Yes	No	10	5	3
232	R:R:A102	R:R:I122	3.25	No	Yes	0	5	6
233	R:R:A372	R:R:L66	3.15	No	Yes	0	6	6
234	R:R:A308	R:R:L228	3.15	No	Yes	0	5	6
235	R:R:E191	R:R:P190	3.14	No	No	0	1	1
236	R:R:I356	R:R:V59	3.07	No	No	0	7	5
237	R:R:M176	R:R:V128	3.04	Yes	No	0	8	6
238	R:R:A70	R:R:Q368	3.03	No	No	0	7	7
239	R:R:R73	R:R:W72	3	No	No	0	6	3
240	R:R:L61	R:R:V93	2.98	Yes	No	0	6	7
241	R:R:L66	R:R:V62	2.98	Yes	No	0	6	4
242	R:R:L125	R:R:V121	2.98	No	No	0	6	4
243	R:R:L135	R:R:V171	2.98	No	No	0	7	5
244	R:R:L312	R:R:V316	2.98	No	No	0	6	6
245	R:R:L320	R:R:V316	2.98	No	No	0	5	6
246	R:R:N82	R:R:V71	2.96	Yes	No	0	9	8
247	R:R:L300	R:R:T296	2.95	Yes	No	0	8	8
248	R:R:I148	R:R:I238	2.94	Yes	No	0	9	9
249	R:R:I148	R:R:K241	2.91	Yes	No	0	9	5
250	R:R:L137	R:R:M231	2.83	No	Yes	0	9	8
251	R:R:L228	R:R:M231	2.83	Yes	Yes	0	6	8
252	R:R:G115	R:R:W112	2.81	No	Yes	0	8	8
253	R:R:L105	R:R:L113	2.77	No	No	0	5	3
254	R:R:A338	R:R:Y45	2.67	No	No	0	2	4
255	R:R:A158	R:R:Y83	2.67	No	No	0	4	4
256	R:R:A95	R:R:Y348	2.67	No	Yes	0	8	7
257	R:R:R197	R:R:S200	2.64	No	No	0	3	3
258	R:R:A51	R:R:W47	2.59	No	No	0	4	3
259	R:R:A234	R:R:W145	2.59	No	Yes	0	7	8
260	R:R:A211	R:R:W206	2.59	No	Yes	0	4	7
261	R:R:A297	R:R:W243	2.59	No	Yes	0	7	6
262	L:L:?1	R:R:N318	2.56	Yes	No	0	0	7
263	R:R:V71	R:R:Y83	2.52	No	No	0	8	4
264	R:R:F360	R:R:I356	2.51	No	No	0	5	7
265	R:R:V48	R:R:W47	2.45	No	No	0	7	3
266	R:R:F373	R:R:L66	2.44	No	Yes	0	6	6
267	R:R:L94	R:R:W169	2.28	No	No	0	7	9
268	R:R:R291	R:R:R294	2.13	No	No	0	6	6
269	R:R:F373	R:R:W376	2	No	No	0	6	3
270	R:R:A170	R:R:G167	1.95	No	No	0	4	4
271	R:R:A232	R:R:G229	1.95	No	No	0	5	4
272	R:R:A226	R:R:P227	1.87	No	No	0	5	9
273	R:R:A141	R:R:A234	1.79	No	No	0	9	7
274	R:R:P178	R:R:V177	1.77	No	No	0	7	5
275	R:R:A193	R:R:S187	1.71	No	Yes	10	1	5
276	R:R:A193	R:R:S200	1.71	No	No	10	1	3
277	R:R:A353	R:R:V306	1.7	No	No	0	6	6
278	R:R:A253	R:R:T251	1.68	No	No	0	7	4
279	R:R:L189	R:R:P190	1.64	No	No	0	3	1
280	R:R:C218	R:R:I214	1.64	No	No	0	4	4
281	R:R:A46	R:R:I108	1.62	No	No	0	7	5
282	R:R:S187	R:R:V188	1.62	Yes	No	0	5	1
283	R:R:A226	R:R:I221	1.62	No	No	0	5	5
284	R:R:A46	R:R:K43	1.61	No	No	0	7	4
285	R:R:V58	R:R:V62	1.6	No	No	0	5	4
286	R:R:T65	R:R:V93	1.59	No	No	0	4	7
287	R:R:C68	R:R:L90	1.59	No	No	0	7	5
288	R:R:T223	R:R:V222	1.59	No	No	0	6	5
289	R:R:T250	R:R:V287	1.59	No	No	0	3	4
290	R:R:A97	R:R:L61	1.58	No	Yes	0	5	6
291	R:R:A133	R:R:L88	1.58	No	No	0	9	9
292	R:R:A339	R:R:L317	1.58	No	No	0	5	5
293	R:R:I50	R:R:V54	1.54	No	No	0	7	3
294	R:R:L189	R:R:V188	1.49	No	No	0	3	1
295	R:R:D203	R:R:V201	1.46	No	No	0	5	4
296	R:R:D332	R:R:V336	1.46	No	No	0	3	4
297	R:R:K120	R:R:M183	1.44	No	No	0	7	4
298	R:R:Q329	R:R:S331	1.44	No	No	0	3	5
299	R:R:L230	R:R:M233	1.41	No	No	0	7	5
300	R:R:P178	R:R:Y215	1.39	No	Yes	0	7	7
301	R:R:L66	R:R:L69	1.38	Yes	No	0	6	4
302	R:R:A371	R:R:R73	1.38	No	No	0	4	6
303	R:R:L305	R:R:L309	1.38	No	No	0	5	5
304	R:R:D208	R:R:L210	1.36	No	No	0	4	3
305	R:R:R159	R:R:T157	1.29	No	No	0	5	8
306	R:R:Q329	R:R:R328	1.17	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y53	7.75286	7	1	7
2	R:R:L61	3.7675	4	1	6
3	R:R:L66	2.72	5	0	6
4	R:R:M77	8.885	4	2	8
5	R:R:N82	5.115	4	2	9
6	R:R:F84	5.292	5	0	8
7	R:R:N87	9.045	4	0	9
8	R:R:D92	8.675	4	2	9
9	R:R:L100	7.7375	4	1	8
10	R:R:W112	8.39333	6	5	8
11	R:R:I122	4.2625	4	0	6
12	R:R:Y124	5.5525	4	8	6
13	R:R:Q126	10.495	4	1	8
14	R:R:V132	7.5025	4	0	7
15	R:R:W145	8.398	5	9	8
16	R:R:Y146	7.8	4	0	5
17	R:R:I148	5.0375	4	0	9
18	R:R:I168	5.84	4	0	7
19	R:R:M176	4.4525	4	0	8
20	R:R:S187	3.15	4	10	5
21	R:R:E204	10.3	5	3	5
22	R:R:W206	10.656	5	3	7
23	R:R:Y215	6.214	5	0	7
24	R:R:F219	6.925	4	0	6
25	R:R:Y224	8.0975	4	0	8
26	R:R:L228	4.765	4	0	6
27	R:R:M231	3.705	4	0	8
28	R:R:Y235	6.0575	4	0	8
29	R:R:W243	11.7925	4	0	6
30	R:R:L300	4.965	4	0	8
31	R:R:F307	8.538	5	0	9
32	R:R:I314	8.5175	4	1	7
33	R:R:R322	14.865	4	3	6
34	R:R:F327	5.285	6	4	3
35	R:R:H344	13.3	4	1	7
36	R:R:W345	6.525	6	1	7
37	R:R:Y348	6.20143	7	1	7
38	R:R:N354	6.15	5	2	9
39	R:R:Y358	8.242	5	2	9
40	R:R:F365	7.26833	6	2	8
41	L:L:?1	10.8709	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L49	R:R:Y53	14.2126	4.69	No	Yes	0	5	7
2	R:R:I108	R:R:L49	11.5905	5.71	No	No	0	5	5
3	R:R:W345	R:R:Y53	14.2615	11.58	Yes	Yes	1	7	7
4	R:R:S103	R:R:Y53	12.8265	3.82	No	Yes	1	7	7
5	R:R:Y348	R:R:Y53	16.1954	4.96	Yes	Yes	1	7	7
6	R:R:N350	R:R:N354	81.7728	6.81	No	Yes	0	9	9
7	R:R:F307	R:R:N350	84.147	4.83	Yes	No	0	9	9
8	R:R:F307	R:R:Y311	100	21.66	Yes	No	0	9	8
9	R:R:V130	R:R:Y311	52.94	6.31	No	No	0	7	8
10	L:L:?1	R:R:V130	46.5153	3.7	Yes	No	1	0	7
11	R:R:V347	R:R:Y311	48.0123	10.09	No	No	0	7	8
12	L:L:?1	R:R:V347	46.5219	3.7	Yes	No	1	0	7
13	R:R:N354	R:R:Y358	63.6696	5.81	Yes	Yes	2	9	9
14	R:R:F365	R:R:F369	24.5214	5.36	Yes	No	0	8	7
15	R:R:F365	R:R:Y358	53.0672	10.32	Yes	Yes	2	8	9
16	R:R:F369	R:R:L66	12.4678	3.65	No	Yes	0	7	6
17	R:R:F365	R:R:N82	15.2268	6.04	Yes	Yes	2	8	9
18	R:R:N82	R:R:V71	12.4678	2.96	Yes	No	0	9	8
19	R:R:M77	R:R:N74	10.9317	14.02	Yes	No	0	8	6
20	R:R:F365	R:R:M77	13.7038	8.71	Yes	Yes	2	8	8
21	R:R:I140	R:R:L300	42.2724	4.28	No	Yes	0	8	8
22	R:R:F84	R:R:I140	43.2313	5.02	Yes	No	0	8	8
23	R:R:F139	R:R:F84	44.04	8.57	No	Yes	0	7	8
24	R:R:F139	R:R:I168	44.963	8.79	No	Yes	0	7	7
25	R:R:I168	R:R:V132	50.7941	4.61	Yes	Yes	0	7	7
26	R:R:S172	R:R:V132	57.6852	4.85	No	Yes	0	8	7
27	R:R:S131	R:R:S172	58.5331	6.52	No	No	0	8	8
28	R:R:M176	R:R:S131	60.2094	4.6	Yes	No	0	8	8
29	R:R:F219	R:R:M176	66.621	3.73	Yes	Yes	0	6	8
30	L:L:?1	R:R:F219	79.7378	4.54	Yes	Yes	0	0	6
31	R:R:I122	R:R:W112	24.7203	4.7	Yes	Yes	0	6	8
32	R:R:I122	R:R:P123	33.4442	3.39	Yes	No	0	6	6
33	L:L:?1	R:R:P123	40.4396	10.21	Yes	No	0	0	6
34	R:R:G115	R:R:W112	15.217	2.81	No	Yes	0	8	8
35	R:R:G115	R:R:R197	14.0854	7.51	No	No	0	8	3
36	R:R:F307	R:R:L228	21.371	4.87	Yes	Yes	0	9	6
37	R:R:A141	R:R:Y235	11.8351	4	No	Yes	0	9	8
38	R:R:L300	R:R:Y235	33.3496	8.21	Yes	Yes	0	8	8
39	R:R:A141	R:R:A234	10.6806	1.79	No	No	0	9	7
40	R:R:I148	R:R:I238	19.5186	2.94	Yes	No	0	9	9
41	R:R:I238	R:R:Y235	20.6307	4.84	No	Yes	0	9	8
42	R:R:I148	R:R:L242	15.1649	4.28	Yes	No	0	9	8
43	R:R:F219	R:R:Y215	25.702	5.16	Yes	Yes	0	6	7
44	R:R:H216	R:R:Y215	10.9089	7.62	No	Yes	0	6	7
45	R:R:S187	R:R:S200	10.6219	3.26	Yes	No	10	5	3
46	R:R:R197	R:R:S200	12.9472	2.64	No	No	0	3	3
47	R:R:L242	R:R:W243	14.0397	4.56	No	Yes	0	8	6
48	R:R:R294	R:R:W243	10.5926	27.99	No	Yes	0	6	6
49	R:R:F369	R:R:N359	10.9317	8.46	No	No	0	7	7
50	L:L:?1	R:R:Y348	25.4672	4.37	Yes	Yes	1	0	7
51	L:L:?1	R:R:S103	13.6386	13.07	Yes	No	1	0	7
52	R:R:L228	R:R:Y224	15.3149	8.21	Yes	Yes	0	6	8
53	R:R:L100	R:R:Y348	11.2089	11.72	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L100	R:R:Y53	8.21	1	Yes	Yes	8	7	2	2
R:R:S103	R:R:Y53	3.82	1	No	Yes	7	7	1	2
R:R:D107	R:R:Y53	4.6	0	No	Yes	6	7	2	2
R:R:Y348	R:R:Y53	4.96	1	Yes	Yes	7	7	1	2
R:R:C99	R:R:Q126	6.1	1	No	Yes	8	8	2	1
R:R:C99	R:R:Y348	4.03	1	No	Yes	8	7	2	1
R:R:L100	R:R:Y348	11.72	1	Yes	Yes	8	7	2	1
R:R:S103	R:R:Y348	8.9	1	No	Yes	7	7	1	1
L:L:?1	R:R:S103	13.07	1	Yes	No	0	7	0	1
L:L:?1	R:R:V106	3.7	1	Yes	No	0	6	0	1
R:R:D107	R:R:H344	13.87	0	No	Yes	6	7	2	1
R:R:M183	R:R:P123	8.39	0	No	No	4	6	2	1
L:L:?1	R:R:P123	10.21	1	Yes	No	0	6	0	1
R:R:Q126	R:R:V130	4.3	1	Yes	No	8	7	1	1
R:R:Q126	R:R:Y348	6.76	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:Q126	24.82	1	Yes	Yes	0	8	0	1
R:R:V130	R:R:Y311	6.31	1	No	No	7	8	1	2
L:L:?1	R:R:V130	3.7	1	Yes	No	0	7	0	1
R:R:F219	R:R:M176	3.73	0	Yes	Yes	6	8	1	2
R:R:F219	R:R:Y215	5.16	0	Yes	Yes	6	7	1	2
R:R:F219	R:R:T223	14.27	0	Yes	No	6	6	1	2
L:L:?1	R:R:F219	4.54	1	Yes	Yes	0	6	0	1
R:R:V347	R:R:Y311	10.09	1	No	No	7	8	1	2
R:R:I314	R:R:S343	7.74	1	Yes	No	7	6	1	2
R:R:H344	R:R:I314	3.98	1	Yes	Yes	7	7	1	1
R:R:I314	R:R:V347	4.61	1	Yes	No	7	7	1	1
L:L:?1	R:R:I314	17.74	1	Yes	Yes	0	7	0	1
R:R:H344	R:R:S343	4.18	1	Yes	No	7	6	1	2
L:L:?1	R:R:H344	31.17	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V347	3.7	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y348	4.37	1	Yes	Yes	0	7	0	1
R:R:I122	R:R:P123	3.39	0	Yes	No	6	6	2	1
R:R:A95	R:R:Y348	2.67	0	No	Yes	8	7	2	1
L:L:?1	R:R:N318	2.56	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
76.92	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
76.92	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
76.92	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
75.00	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
75.00	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
75.00	Single	6TPG	EMPA	6TPG-OX₂-EMPA
75.00	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
71.43	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
69.23	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
66.67	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
66.67	Single	5WS3	EMPA	5WS3-OX₂-EMPA
66.67	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
66.67	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
66.67	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
66.67	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
66.67	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
66.67	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
64.29	Single	5WQC	EMPA	5WQC-OX₂-EMPA
64.29	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
64.29	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
64.29	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
62.50	Consensus	endothelin_off	Orthosteric Ligand	etb_off
62.50	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
61.54	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
61.54	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
61.54	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
61.54	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
60.00	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
60.00	Single	8E0G	BU72	8E0G-μ-BU72
60.00	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
58.33	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
57.14	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
57.14	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
57.14	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
57.14	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
57.14	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
56.25	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
56.25	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
56.25	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
56.25	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
56.25	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
56.25	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
55.56	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
53.85	Single	6AKX	A4R	6AKX-CCR5-A4R
53.85	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
53.85	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
53.85	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33	Single	5C1M	BU72	5C1M-μ-BU72
53.33	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
53.33	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
52.94	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
52.94	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
52.94	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
52.94	Consensus	orexin_on	Orthosteric Ligand	ox2_on
50.00	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
50.00	Single	2YDV	NECA	2YDV-A_2A-NECA
50.00	Single	4DJH	JDTic	4DJH-κ-JDTic
50.00	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
50.00	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
50.00	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
50.00	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
50.00	Single	5G53	NECA	5G53-A_2A-NECA-Gs
50.00	Single	5X93	K-8794	5X93-ET_B-K-8794
50.00	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
50.00	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
50.00	Single	6IQL	L745870	6IQL-D₄-L745870
50.00	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
50.00	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
50.00	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
50.00	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
50.00	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
50.00	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
50.00	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
50.00	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
50.00	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
50.00	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
50.00	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
50.00	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
50.00	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
50.00	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
50.00	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
50.00	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
50.00	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
50.00	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
50.00	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
50.00	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
50.00	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
50.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
50.00	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
50.00	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
50.00	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
50.00	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.37	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
47.37	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
47.37	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
47.06	Single	4LDE	BI167107	4LDE-β₂-BI167107
47.06	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
47.06	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
47.06	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
47.06	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
47.06	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
46.67	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
46.67	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
46.67	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
46.67	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
46.67	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
46.67	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
46.67	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
46.67	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
46.67	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
46.67	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
46.67	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
46.67	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
46.67	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
46.67	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
46.67	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
46.67	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
46.67	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
46.67	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
46.67	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
46.67	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
46.67	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
46.67	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
46.67	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
46.67	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
46.67	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
46.67	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
46.67	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
46.67	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
46.67	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
46.67	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
46.67	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
46.67	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
46.67	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
46.15	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
46.15	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
46.15	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
46.15	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
46.15	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
45.83	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
45.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
44.44	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
44.44	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
44.44	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
44.44	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
44.44	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
44.44	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
44.44	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
44.44	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
44.44	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
43.75	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
43.75	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
43.75	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
43.75	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
43.75	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
43.75	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
43.75	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
43.75	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
43.75	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
43.75	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
43.75	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
43.75	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
43.75	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
43.75	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
43.75	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
43.75	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
43.75	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
43.75	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
43.75	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
43.75	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
43.75	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
43.75	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
43.75	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
43.75	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
43.75	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
43.75	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
43.75	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
43.75	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
43.75	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
43.75	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
43.75	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
43.48	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
42.86	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
42.86	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
42.86	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
42.86	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
42.86	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
42.86	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
42.86	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
42.86	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
42.86	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
42.86	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
42.86	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
42.86	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
42.86	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
42.86	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
42.86	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
42.86	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
42.86	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
42.86	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
42.86	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
42.86	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
42.86	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
42.86	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
42.86	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
42.86	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
42.86	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
42.86	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
42.86	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
42.86	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
42.11	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
42.11	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
42.11	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
42.11	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
42.11	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
42.11	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
42.11	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
42.11	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
41.67	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
41.18	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
41.18	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
41.18	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
41.18	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
41.18	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
41.18	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
41.18	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
41.18	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
41.18	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
41.18	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
41.18	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
41.18	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
41.18	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
41.18	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
41.18	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
41.18	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
41.18	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
41.18	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
41.18	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
41.18	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
41.18	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
41.18	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
41.18	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
41.18	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
41.18	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
41.18	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
41.18	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
41.18	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
41.18	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
41.18	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
41.18	Consensus	histamine_off	Orthosteric Ligand	h1_off
41.18	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
41.18	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
41.18	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
41.18	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
40.91	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
40.91	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
40.00	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
40.00	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
40.00	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
40.00	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
40.00	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
40.00	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
40.00	Single	6VI4	JDTic	6VI4-κ-JDTic
40.00	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
40.00	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
40.00	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
40.00	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
40.00	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
40.00	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
40.00	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
40.00	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
40.00	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
40.00	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
40.00	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
40.00	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
40.00	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
40.00	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
40.00	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
40.00	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
40.00	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
40.00	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
40.00	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
40.00	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
40.00	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
40.00	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
40.00	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
40.00	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
40.00	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
40.00	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
40.00	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
40.00	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
40.00	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
40.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
40.00	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
40.00	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
40.00	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
40.00	Consensus	hcar_on	Orthosteric Ligand	hca_on
40.00	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
40.00	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
39.13	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
39.13	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
38.89	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
38.89	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
38.89	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
38.89	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
38.89	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
38.89	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
38.89	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
38.89	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
38.89	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
38.89	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
38.89	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
38.89	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
38.89	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
38.89	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
38.89	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
38.89	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
38.89	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
38.89	Consensus	blt_off	Orthosteric Ligand	blt1_off
38.89	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
38.89	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
38.89	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.89	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.89	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
38.89	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
38.89	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
38.46	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
38.46	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
38.46	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
38.46	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
38.46	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
38.46	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
38.46	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
38.10	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
38.10	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
38.10	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
38.10	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
38.10	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
37.50	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
37.50	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
37.50	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
37.50	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
37.50	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
37.50	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
37.50	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
37.50	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
37.50	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
37.50	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
37.50	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
37.50	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
37.50	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
37.50	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
37.50	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
37.50	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
37.50	Single	6PS1	Timolol	6PS1-β₂-Timolol
37.50	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
37.50	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50	Single	7BU7	BI167107	7BU7-β₁-BI167107
37.50	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
37.50	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
37.50	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
37.50	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
37.50	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
37.50	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
37.50	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
37.50	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
37.50	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
37.50	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
37.50	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
37.50	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
37.50	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
37.50	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
37.50	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
37.50	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
37.50	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
37.50	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
37.50	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
37.50	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
37.50	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
37.50	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
37.50	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
37.50	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
37.50	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
37.50	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
37.50	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
37.50	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
37.50	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
37.50	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
37.50	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
37.50	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
37.50	Consensus	tar_on	Orthosteric Ligand	ta1_on
36.84	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
36.84	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
36.84	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
36.84	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
36.84	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
36.84	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
36.84	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
36.84	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
36.84	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
36.84	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
36.84	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
36.84	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
36.84	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
36.84	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
36.36	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
36.36	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
36.36	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
36.36	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
36.36	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
35.71	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
35.71	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
35.71	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
35.71	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
35.71	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
35.71	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
35.71	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
35.71	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
35.71	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
35.71	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
35.71	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
35.71	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
35.71	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
35.71	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
35.71	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
35.71	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
35.71	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
35.71	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
35.71	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
35.71	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
35.29	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
35.29	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
35.29	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
35.29	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
35.29	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
35.29	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
35.29	Single	6PS6	Timolol	6PS6-β₂-Timolol
35.29	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
35.29	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
35.29	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
35.29	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
35.29	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
35.29	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
35.29	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
35.29	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
35.29	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
35.29	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
35.29	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
35.29	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
35.29	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
35.29	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
35.29	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
35.29	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.29	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
35.29	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.29	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
35.29	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.29	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
35.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
35.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
35.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
35.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
35.00	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
35.00	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
35.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
35.00	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
34.62	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
34.62	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
33.33	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
33.33	Single	3P0G	BI167107	3P0G-β₂-BI167107
33.33	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
33.33	Single	3PXO	All-trans-retinal	3PXO-Rhodopsin-All-trans-retinal
33.33	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
33.33	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
33.33	Single	5DYS	All-trans-retinal	5DYS-Rhodopsin-All-trans-retinal
33.33	Single	5XRA	AM11542	5XRA-CB₁-AM11542
33.33	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
33.33	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
33.33	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
33.33	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
33.33	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
33.33	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
33.33	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
33.33	Single	7EPE	NAM563	7EPE-mGlu-NAM563
33.33	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
33.33	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
33.33	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
33.33	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33	Single	7QA8	Peptide	7QA8-STE2-Peptide
33.33	Single	7QA8	Peptide	7QA8-STE2-Peptide
33.33	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
33.33	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
33.33	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
33.33	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
33.33	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
33.33	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
33.33	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
33.33	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
33.33	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
33.33	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
33.33	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
33.33	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
33.33	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
33.33	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
33.33	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
33.33	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
33.33	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
33.33	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
33.33	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
33.33	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
33.33	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
33.33	Consensus	class-d_off	Orthosteric Ligand	ste2_off
33.33	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
33.33	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
33.33	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
33.33	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
33.33	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
33.33	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
32.00	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
32.00	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
32.00	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
31.82	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
31.82	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
31.82	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.82	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.82	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
31.82	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
31.58	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
31.58	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
31.58	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
31.58	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
31.58	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
31.58	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
31.58	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
31.58	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
31.58	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
31.58	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
31.58	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.58	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
31.58	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
31.58	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
31.58	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
31.58	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
31.58	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
31.58	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
31.58	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
31.58	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
31.58	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
31.58	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
31.58	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
31.58	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
31.58	Consensus	gi_class-f	Other Ligand	gi_frizzled
31.58	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
31.58	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
31.58	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
31.58	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
31.58	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
31.58	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
31.25	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
31.25	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
31.25	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
31.25	Single	6TPK	Retosiban	6TPK-OT-Retosiban
31.25	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
31.25	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
31.25	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
31.25	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.25	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
31.25	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
31.25	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
31.25	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
31.25	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
31.25	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
31.25	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
31.25	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
31.25	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
31.25	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
31.25	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
31.25	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
31.25	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
31.25	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
31.25	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
31.25	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
30.77	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.77	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
30.77	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.77	Single	7MTB	All-trans-retinal	7MTB-Rhodopsin-All-trans-retinal-GRK1
30.77	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
30.77	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
30.77	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
30.77	Consensus	sensory_on	Orthosteric Ligand	opsin_on
30.43	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
30.43	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
30.43	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.43	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
30.43	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
30.43	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
30.43	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.43	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
30.43	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
30.00	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
30.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
30.00	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
30.00	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
30.00	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
30.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
30.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
30.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
30.00	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
30.00	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
30.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
30.00	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.00	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
30.00	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
30.00	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
30.00	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
30.00	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
29.63	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
29.63	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
29.41	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
29.41	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
29.41	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
29.41	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
29.41	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
29.41	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
29.41	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
29.41	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
29.41	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
29.41	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
29.41	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
29.41	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
29.41	Single	6GPS	MK0812	6GPS-CCR2-MK0812
29.41	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
29.41	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
29.41	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
29.41	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.41	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
29.41	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
29.41	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
29.41	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
29.41	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
29.41	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
29.41	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
29.41	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
29.41	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
29.41	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
29.41	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
29.41	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
29.41	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
29.41	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
29.41	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
29.41	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
29.41	Consensus	blt_on	Orthosteric Ligand	blt1_on
29.41	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
29.41	Consensus	cck_off	Orthosteric Ligand	ccka_off
29.41	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
29.41	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
29.41	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
29.41	Consensus	hcar_off	Orthosteric Ligand	succinate_off
29.41	Consensus	leuko_on	Orthosteric Ligand	blt_on
29.41	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
29.41	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
29.41	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
29.41	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
29.17	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
29.17	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
29.17	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
29.17	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
29.17	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
29.17	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
29.17	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
29.17	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
29.17	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
29.17	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
28.57	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
28.57	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
28.57	Single	6FUF	All-trans-retinal	6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
28.57	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
28.57	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
28.57	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
28.57	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
28.57	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
28.57	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
28.57	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
28.57	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
28.57	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
28.57	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
28.57	Consensus	class-d_off	Orthosteric Ligand	ste2_off
28.57	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
28.57	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
28.57	Consensus	opsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
28.00	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
28.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.00	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.00	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
27.78	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
27.78	Single	5N2S	PSB36	5N2S-A₁-PSB36
27.78	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
27.78	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
27.78	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
27.78	Single	6GPX	MK0812	6GPX-CCR2-MK0812
27.78	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
27.78	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
27.78	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
27.78	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.78	Single	7C4S	S1P	7C4S-S1P₃-S1P
27.78	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
27.78	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
27.78	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
27.78	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
27.78	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
27.78	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
27.78	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
27.78	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
27.78	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
27.78	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
27.78	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
27.78	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
27.78	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
27.78	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
27.59	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
27.27	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
27.27	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
27.27	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
27.27	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
27.27	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
27.27	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
27.27	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
27.27	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
27.27	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
27.27	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
26.92	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
26.92	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
26.92	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
26.92	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.67	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
26.67	Single	6HLL	CP99994	6HLL-NK₁-CP99994
26.67	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
26.67	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
26.67	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
26.67	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
26.67	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
26.67	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
26.67	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
26.67	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
26.67	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
26.67	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
26.67	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
26.67	Consensus	class-t_on	Orthosteric Ligand	taste2_on
26.67	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
26.67	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
26.67	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
26.32	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
26.32	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
26.32	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
26.32	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
26.32	Single	5XR8	AM841	5XR8-CB₁-AM841
26.32	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
26.32	Single	6E59	L-760735	6E59-NK₁-L-760735
26.32	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
26.32	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
26.32	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
26.32	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
26.32	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
26.32	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
26.32	Single	7P2L	4YI	7P2L-mGlu₅-4YI
26.32	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
26.32	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
26.32	Single	7W41	PD176252	7W41-BB₂-PD176252
26.32	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
26.32	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
26.32	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
26.32	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
26.32	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.32	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
26.32	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
26.32	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
26.32	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
26.32	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
26.32	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
26.32	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
26.32	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
26.32	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
26.32	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.32	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
26.32	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
26.32	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
26.32	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
26.32	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
26.32	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
26.32	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
26.09	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
26.09	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
26.09	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
26.09	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
26.09	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
26.09	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
26.09	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
26.09	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
26.09	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
25.93	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
25.93	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
25.81	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
25.00	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
25.00	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
25.00	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
25.00	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
25.00	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
25.00	Single	4A4M	All-trans-retinal	4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
25.00	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
25.00	Single	5EN0	All-trans-retinal	5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
25.00	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
25.00	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
25.00	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
25.00	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
25.00	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
25.00	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
25.00	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
25.00	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
25.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
25.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
25.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
25.00	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
25.00	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
25.00	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
25.00	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
25.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
25.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
25.00	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
25.00	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
25.00	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
25.00	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
25.00	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
25.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
25.00	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
25.00	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
25.00	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
25.00	Consensus	dp_off	Orthosteric Ligand	dp2_off
25.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
25.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
25.00	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
25.00	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
25.00	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
24.14	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
24.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
24.00	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
24.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
24.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
24.00	Consensus	class-d_on	Orthosteric Ligand	ste2_on
24.00	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
24.00	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.00	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
24.00	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.81	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
23.81	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
23.81	Single	7EZC	UKA	7EZC-A_2A-UKA
23.81	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.81	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
23.81	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
23.81	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
23.81	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
23.81	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
23.81	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
23.81	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
23.53	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
23.53	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
23.53	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
23.53	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
23.53	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
23.53	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
23.53	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
23.53	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.53	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
23.53	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
23.53	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
23.53	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
23.53	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
23.53	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
23.53	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
23.53	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
23.53	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
23.53	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
23.33	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
23.33	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
23.08	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
23.08	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
23.08	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
23.08	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
23.08	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
23.08	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.08	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
23.08	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
23.08	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
23.08	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
22.73	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
22.73	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
22.73	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
22.73	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
22.22	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
22.22	Single	5UEN	DU172	5UEN-A₁-DU172
22.22	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
22.22	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
22.22	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
22.22	Single	6D27	CAY10471	6D27-DP₂-CAY10471
22.22	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
22.22	Single	6IIV	Daltroban	6IIV-TP-Daltroban
22.22	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
22.22	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
22.22	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
22.22	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
22.22	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
22.22	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
22.22	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
22.22	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
22.22	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
22.22	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
22.22	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
22.22	Consensus	class-d_on	Orthosteric Ligand	ste2_on
22.22	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.22	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
22.22	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
22.22	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
21.88	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
21.74	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
21.74	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.74	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
21.74	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
21.74	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.74	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
21.74	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
21.74	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
21.62	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.43	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
21.43	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.43	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
21.43	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
21.43	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
21.43	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.43	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
21.43	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
21.43	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
21.43	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.21	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
21.05	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
21.05	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
21.05	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
21.05	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
21.05	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
21.05	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.05	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.05	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
21.05	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.05	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
21.05	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
21.05	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
21.05	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
21.05	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
21.05	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
21.05	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
21.05	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
21.05	Consensus	ep_off	Orthosteric Ligand	ep4_off
21.05	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
20.83	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.83	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
20.69	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
20.69	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
20.69	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
20.00	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
20.00	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
20.00	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
20.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
20.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
20.00	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
20.00	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
20.00	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
20.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
20.00	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
20.00	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
20.00	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
20.00	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
20.00	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
20.00	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
20.00	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
20.00	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
20.00	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
20.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
20.00	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.00	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
20.00	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
20.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
20.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
20.00	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.00	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
20.00	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
19.23	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.23	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
19.23	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.23	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
19.05	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
19.05	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
19.05	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
19.05	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
19.05	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
19.05	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
19.05	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
19.05	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
19.05	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
19.05	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
19.05	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
19.05	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
19.05	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
18.75	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
18.75	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
18.75	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
18.75	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
18.75	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
18.75	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
18.75	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
18.75	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
18.75	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
18.75	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
18.75	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
18.75	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.75	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
18.75	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
18.75	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
18.75	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.75	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
18.75	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.75	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
18.52	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
18.52	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
18.52	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
18.52	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
18.52	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.52	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
18.18	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
18.18	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
18.18	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
18.18	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
18.18	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
18.18	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
18.18	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
18.18	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
17.86	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
17.86	Single	6FJ3	PTH	6FJ3-PTH1-PTH
17.86	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
17.86	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
17.65	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
17.65	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
17.65	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
17.65	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
17.65	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
17.65	Single	5U09	Taranabant	5U09-CB₁-Taranabant
17.65	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
17.65	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
17.65	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
17.65	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
17.65	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.65	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
17.65	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
17.65	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
17.65	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
17.65	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.65	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
17.65	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
17.65	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
17.65	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
17.65	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
17.65	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
17.65	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.65	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
17.65	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
17.65	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
17.65	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
17.65	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
17.39	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.39	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.39	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
17.24	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
17.24	Consensus	go_class-b1	Orthosteric Ligand	go_crf
17.24	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
16.67	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
16.67	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
16.67	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
16.67	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
16.67	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
16.67	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
16.67	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
16.67	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
16.67	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
16.67	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
16.67	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
16.67	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
16.67	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
16.67	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
16.67	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
16.67	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
16.67	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
16.67	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
16.67	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
16.67	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
16.67	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
16.67	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
16.67	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
16.67	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
16.67	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.67	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
16.67	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
16.67	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
16.67	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.67	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
16.67	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
16.67	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
16.67	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67	Consensus	sensory_off	Orthosteric Ligand	opsin_off
16.13	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.13	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.13	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
16.00	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
16.00	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
16.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.00	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79	Single	3EML	ZM241385	3EML-A_2A-ZM241385
15.79	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
15.79	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
15.79	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
15.79	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
15.79	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
15.79	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
15.79	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
15.79	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
15.79	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
15.79	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
15.79	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
15.79	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
15.79	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
15.79	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
15.79	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
15.79	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
15.79	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
15.79	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.79	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.79	Consensus	a2_off	Orthosteric Ligand	a2a_off
15.79	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
15.79	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
15.79	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
15.79	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
15.79	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
15.79	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
15.79	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.62	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
15.62	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.62	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
15.38	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
15.38	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
15.38	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.38	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
15.38	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
15.38	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.15	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.00	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
15.00	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
15.00	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
15.00	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
15.00	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
15.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
15.00	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
15.00	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
15.00	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
15.00	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
15.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
15.00	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
15.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
15.00	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
14.81	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
14.81	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
14.81	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.71	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
14.71	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
14.29	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.29	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.29	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
14.29	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
14.29	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
14.29	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
14.29	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
14.29	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
14.29	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
14.29	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
14.29	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.79	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
13.79	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.79	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
13.79	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.64	Single	6OS2	TRV026	6OS2-AT₁-TRV026
13.64	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
13.64	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
13.64	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.64	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.64	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
13.64	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
13.64	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
13.64	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.33	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
13.33	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
13.33	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.33	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.33	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.33	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
13.33	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
13.33	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.04	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
13.04	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.04	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
13.04	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
13.04	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
13.04	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
13.04	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.90	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.90	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.90	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.90	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.90	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.90	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.90	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
12.90	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.90	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
12.50	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.50	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
12.50	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
12.50	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
12.50	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
12.50	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
12.50	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.50	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
12.50	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
12.50	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
12.50	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
12.50	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.50	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
12.50	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
12.12	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
12.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
12.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
12.00	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
12.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
11.76	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
11.76	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
11.76	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
11.76	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
11.54	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.54	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.54	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Consensus	sst_off	Orthosteric Ligand	sst2_off
11.11	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
11.11	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
11.11	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.11	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.11	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
11.11	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
11.11	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
11.11	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
10.71	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.71	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
10.53	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
10.53	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
10.53	Single	7T32	ZM241385	7T32-A_2A-ZM241385
10.53	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.53	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
10.53	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
10.53	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
10.53	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.34	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.34	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.34	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.34	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.26	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.26	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
10.00	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.00	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
10.00	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.00	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
10.00	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
10.00	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.00	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.00	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
10.00	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.68	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
9.68	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
9.68	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.52	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
9.52	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
9.52	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
9.52	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
9.52	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.52	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.52	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
9.38	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
9.38	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
9.09	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
9.09	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
9.09	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
9.09	Single	5V56	TC114	5V56-SMO-TC114
9.09	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
9.09	Single	6OS1	TRV026	6OS1-AT₁-TRV026
9.09	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
9.09	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
9.09	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
9.09	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	class-c_off	Other Ligand	gabab_off mglu_off
9.09	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.82	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
8.70	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
8.70	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
8.70	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
8.70	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
8.70	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.70	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
8.70	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
8.70	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
8.70	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
8.70	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.70	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.70	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.70	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
8.70	Consensus	nts_off	Orthosteric Ligand	nts1_off
8.57	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.57	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
8.33	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
8.33	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
8.33	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
8.33	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
8.33	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.33	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.00	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
8.00	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.00	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.00	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
7.89	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.69	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
7.41	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.41	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
6.90	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.45	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.45	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.25	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.25	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
6.25	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
5.88	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.88	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
5.88	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.88	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.88	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
5.88	Consensus	adgrg3_on	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
5.71	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.56	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
5.56	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
5.56	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
5.56	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.56	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.41	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.26	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.26	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.26	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.26	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
5.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
5.00	Single	8JD6	N-(3-chlorophenyl)pyridine-2-carboxamide	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
5.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.88	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.76	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
4.76	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.55	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
4.55	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.35	Single	5V57	TC114	5V57-SMO-TC114
4.35	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
4.35	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
4.17	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
4.17	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
4.17	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.17	Consensus	nts_on	Orthosteric Ligand	nts1_on
4.00	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.00	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.85	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
3.70	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.70	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.57	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
3.57	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.03	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.94	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.94	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
2.86	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.86	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.78	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.33	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	6TOT
Class	A
SubFamily	Peptide
Type	Orexin
SubType	OX1
Species	Homo sapiens
Ligand	Lemborexant
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.22
Date	2020-01-15
D.O.I.	10.1021/acs.jmedchem.9b01787

Net Summary
I_min	3.62
Number of Linked Nodes	277
Number of Links	306
Number of Hubs	41
Number of Links mediated by Hubs	164
Number of Communities	10
Number of Nodes involved in Communities	55
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	55655
Length Of Smallest Path	3
Average Path Length	14.1415
Length of Longest Path	36
Minimum Path Strength	1.305
Average Path Strength	6.86128
Maximum Path Strength	27.995
Minimum Path Correlation	0.7
Average Path Correlation	0.934681
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	56.1793
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0115
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NRK
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NRK
Name	Lemborexant
Synonyms	Lemborexant
Identifier	(1~{R},2~{S})-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-~{N}-(5-fluoranylpyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide
Formula	C22 H20 F2 N4 O2
Molecular Weight	410.417
SMILES	Cc1c(cnc(n1)C)OC[C@]2(C[C@H]2C(=O)Nc3ccc(cn3)F)c4cccc(c4)F
PubChem	56944144
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	2
Total Bonds	53
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43613
Sequence	>6TOT_Chain_R K Q Y A W V L I A A Y V A V F V V A L V G N T L V C L A V W R N H H M R T V T N Y F L V N L S L A D V L A T A I C L P A S L L V D I T E S W L F G H A L C K V I P Y L Q A V S V S V A V L T L S F I A L D R W Y A I C H P L L F K S T A R R A L G S I L G I W A V S L A I M V P Q A A V M E C S S V L P E L A A R T R A F S V C D E R W A D D L A P K I Y H S C F F I V T Y L A P L G L M A M A Y F Q I F R K L W G R Q I P G T T S A E V K Q M R A R R K T A K M L M V V V L V F A L C Y L P I S V L N V L K R V F G M F R Q A S D R E A V Y A A F T F S H W L V Y A N S A A N P I I Y N F L S G K F R E Q F K A A F S W W L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This network is also present in following consensuses:
	Id	Components
	ox1_off	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4ZJ8	A	Peptide	Orexin	OX₁	Homo sapiens	Suvorexant	-	-	2.75	2016-03-09	10.1038/nsmb.3183
	4ZJC	A	Peptide	Orexin	OX₁	Homo sapiens	SB-674042	-	-	2.83	2016-03-09	10.1038/nsmb.3183
	6TO7	A	Peptide	Orexin	OX₁	Homo sapiens	Suvorexant	Na	-	2.26	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TOD	A	Peptide	Orexin	OX₁	Homo sapiens	EMPA	Na	-	2.11	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TOS	A	Peptide	Orexin	OX₁	Homo sapiens	GSK1059865	Na	-	2.13	2020-01-15	10.1021/acs.jmedchem.9b01787
	6TP3	A	Peptide	Orexin	OX₁	Homo sapiens	Nemorexant	-	-	3.04	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TP6	A	Peptide	Orexin	OX₁	Homo sapiens	Filorexant	-	-	2.34	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TQ4	A	Peptide	Orexin	OX₁	Homo sapiens	PubChem 16046844	Na	-	2.3	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TQ6	A	Peptide	Orexin	OX₁	Homo sapiens	PubChem 145714283	-	-	2.55	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TQ7	A	Peptide	Orexin	OX₁	Homo sapiens	SB-334867	-	-	2.66	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TQ9	A	Peptide	Orexin	OX₁	Homo sapiens	SB-408124	-	-	2.65	2020-01-01	10.1021/acs.jmedchem.9b01787
	6V9S	A	Peptide	Orexin	OX₁	Homo sapiens	GTPL11403	-	-	3.5	2020-07-15	10.1073/pnas.2002704117

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