psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D12	R:R:R16	13.1	No	No	0	2	3
2	R:R:C13	R:R:Q180	9.16	No	Yes	3	6	4
3	R:R:C13	R:R:C182	7.28	No	No	3	6	3
4	R:R:E14	R:R:V179	4.28	No	No	0	2	4
5	R:R:P20	R:R:R16	4.32	Yes	No	0	2	3
6	R:R:Q97	R:R:W18	5.48	No	No	0	3	1
7	R:R:L19	R:R:P20	4.93	Yes	Yes	0	5	2
8	R:R:E23	R:R:L19	3.98	No	Yes	1	1	5
9	R:R:L19	R:R:Y93	4.69	Yes	Yes	1	5	7
10	R:R:G184	R:R:P20	4.06	No	Yes	0	5	2
11	R:R:E23	R:R:Y93	8.98	No	Yes	1	1	7
12	R:R:E23	R:R:T185	4.23	No	No	1	1	8
13	R:R:P25	R:R:Y93	11.13	No	Yes	0	5	7
14	R:R:I27	R:R:M31	4.37	No	No	1	4	8
15	L:L:?1	R:R:I27	4.81	Yes	No	1	0	4
16	R:R:S28	R:R:V89	4.85	No	No	1	7	7
17	L:L:?1	R:R:S28	9.11	Yes	No	1	0	7
18	R:R:I309	R:R:M31	7.29	No	No	0	9	8
19	L:L:?1	R:R:M31	11.44	Yes	No	1	0	8
20	R:R:F32	R:R:V36	6.55	No	No	0	8	7
21	R:R:F32	R:R:S86	10.57	No	No	0	8	8
22	R:R:I41	R:R:L37	5.71	No	No	0	5	5
23	R:R:L37	R:R:W313	6.83	No	No	0	5	6
24	R:R:G38	R:R:W313	8.44	No	No	0	9	6
25	R:R:L79	R:R:N39	13.73	No	Yes	0	8	9
26	R:R:N39	R:R:P312	8.15	Yes	No	0	9	9
27	R:R:A42	R:R:V75	5.09	No	No	0	9	9
28	R:R:L45	R:R:R48	6.07	No	No	0	7	5
29	R:R:L46	R:R:T72	8.84	No	No	0	9	5
30	R:R:F315	R:R:L46	6.09	No	No	0	9	9
31	R:R:H68	R:R:R49	9.03	No	No	0	8	7
32	R:R:H68	R:R:S65	11.16	No	No	0	8	8
33	R:R:L66	R:R:L70	4.15	No	No	0	6	7
34	R:R:E133	R:R:L66	5.3	Yes	No	0	9	6
35	R:R:F67	R:R:V71	3.93	Yes	No	0	8	8
36	R:R:F67	R:R:M130	6.22	Yes	No	0	8	9
37	R:R:E133	R:R:F67	5.83	Yes	Yes	2	9	8
38	R:R:F67	R:R:R134	4.28	Yes	Yes	2	8	9
39	R:R:F67	R:R:L265	6.09	Yes	No	0	8	8
40	R:R:H262	R:R:H68	7.17	No	No	0	8	8
41	R:R:E73	R:R:V69	4.28	No	No	0	7	7
42	R:R:L70	R:R:M126	4.24	No	Yes	0	7	8
43	R:R:L70	R:R:M130	7.07	No	No	0	7	9
44	R:R:E73	R:R:M126	4.06	No	Yes	0	7	8
45	R:R:E73	R:R:L157	23.85	No	No	0	7	7
46	R:R:D78	R:R:L74	6.79	No	No	4	9	9
47	R:R:L74	R:R:T123	4.42	No	No	4	9	8
48	R:R:L74	R:R:M126	5.65	No	Yes	0	9	8
49	R:R:F76	R:R:L80	12.18	No	No	0	6	5
50	R:R:T77	R:R:Y161	11.24	No	No	0	9	7
51	R:R:D78	R:R:T123	8.67	No	No	4	9	8
52	R:R:D311	R:R:D78	5.32	Yes	No	0	9	9
53	R:R:F119	R:R:G81	9.03	Yes	No	0	8	9
54	R:R:L84	R:R:Y111	4.69	No	No	0	5	6
55	R:R:F112	R:R:I85	6.28	No	No	0	5	6
56	L:L:?1	R:R:I85	25.01	Yes	No	0	0	6
57	R:R:F112	R:R:V88	5.24	No	No	0	5	5
58	L:L:?1	R:R:V89	9.04	Yes	No	1	0	7
59	R:R:S92	R:R:Y93	3.82	No	Yes	0	5	7
60	R:R:T185	R:R:Y93	6.24	No	Yes	1	8	7
61	L:L:?1	R:R:Y93	3.95	Yes	Yes	1	0	7
62	R:R:A101	R:R:Q97	6.06	No	No	0	3	3
63	R:R:Q180	R:R:T98	4.25	Yes	No	0	4	4
64	R:R:S106	R:R:V100	4.85	No	No	0	2	3
65	R:R:E105	R:R:R107	5.82	No	No	0	4	2
66	R:R:C109	R:R:S106	5.16	No	No	0	9	2
67	R:R:C109	R:R:C187	7.28	No	No	0	9	9
68	R:R:T110	R:R:Y178	4.99	No	Yes	0	4	6
69	R:R:A113	R:R:Y178	6.67	No	Yes	0	7	6
70	R:R:F114	R:R:F118	5.36	No	Yes	0	7	7
71	R:R:C168	R:R:F114	4.19	No	No	0	8	7
72	R:R:M116	R:R:W186	5.82	No	Yes	0	7	7
73	R:R:F188	R:R:M116	7.46	Yes	No	0	8	7
74	R:R:C168	R:R:T117	5.07	No	No	0	8	7
75	R:R:F118	R:R:F119	10.72	Yes	Yes	0	7	8
76	R:R:F118	R:R:Y161	6.19	Yes	No	0	7	7
77	R:R:F118	R:R:S164	7.93	Yes	No	0	7	7
78	R:R:F118	R:R:L165	6.09	Yes	No	0	7	4
79	R:R:S120	R:R:Y200	5.09	No	Yes	0	7	7
80	R:R:L304	R:R:S120	9.01	No	No	0	8	7
81	R:R:L121	R:R:L125	5.54	Yes	Yes	0	7	6
82	R:R:L121	R:R:S164	4.5	Yes	No	0	7	7
83	R:R:L121	R:R:Y200	7.03	Yes	Yes	0	7	7
84	R:R:L121	R:R:L203	4.15	Yes	No	0	7	5
85	R:R:L204	R:R:M124	4.24	No	No	0	7	7
86	R:R:F273	R:R:M124	7.46	Yes	No	0	8	7
87	R:R:I160	R:R:L125	7.14	No	Yes	0	6	6
88	R:R:L125	R:R:L207	5.54	Yes	No	0	6	7
89	R:R:L127	R:R:V211	5.96	No	Yes	0	8	8
90	R:R:F273	R:R:L127	15.83	Yes	No	0	8	8
91	R:R:F128	R:R:S210	3.96	No	No	0	6	5
92	R:R:L132	R:R:L136	4.15	No	No	0	6	5
93	R:R:E133	R:R:R134	15.12	Yes	Yes	2	9	9
94	R:R:E133	R:R:Y144	4.49	Yes	No	0	9	8
95	R:R:R134	R:R:S137	7.91	Yes	No	2	9	9
96	R:R:H262	R:R:R134	7.9	No	Yes	0	8	9
97	R:R:S217	R:R:Y135	5.09	No	No	0	6	6
98	R:R:I138	R:R:S137	6.19	Yes	No	2	8	9
99	R:R:E259	R:R:S137	4.31	No	No	2	8	9
100	R:R:I138	R:R:N221	5.66	Yes	No	0	8	6
101	R:R:E259	R:R:I138	5.47	No	Yes	2	8	8
102	R:R:F143	R:R:R146	12.83	No	No	0	4	5
103	R:R:L157	R:R:Y161	4.69	No	No	0	7	7
104	R:R:F167	R:R:Y196	4.13	No	Yes	0	6	6
105	R:R:F167	R:R:Y200	6.19	No	Yes	0	6	7
106	R:R:F167	R:R:L203	8.53	No	No	0	6	5
107	R:R:L170	R:R:Y175	5.86	No	No	0	7	4
108	R:R:L170	R:R:Y196	7.03	No	Yes	0	7	6
109	R:R:P171	R:R:Y178	13.91	No	Yes	0	9	6
110	R:R:P171	R:R:Y196	13.91	No	Yes	0	9	6
111	R:R:Q177	R:R:R190	7.01	No	No	0	3	5
112	R:R:I189	R:R:Y178	7.25	Yes	Yes	0	6	6
113	R:R:V179	R:R:Y181	8.83	No	No	0	4	8
114	R:R:R190	R:R:V179	13.08	No	No	0	5	4
115	R:R:C182	R:R:Q180	9.16	No	Yes	3	3	4
116	R:R:C187	R:R:Q180	4.58	No	Yes	0	9	4
117	R:R:R292	R:R:Y181	9.26	No	No	0	1	8
118	R:R:D297	R:R:Y181	9.2	No	No	0	6	8
119	R:R:C182	R:R:G184	3.92	No	No	0	3	5
120	R:R:P183	R:R:W186	5.4	No	Yes	0	8	7
121	L:L:?1	R:R:T185	7.95	Yes	No	1	0	8
122	R:R:L301	R:R:W186	7.97	No	Yes	0	7	7
123	R:R:S305	R:R:W186	4.94	No	Yes	1	8	7
124	L:L:?1	R:R:W186	19.96	Yes	Yes	1	0	7
125	R:R:F188	R:R:I189	11.3	Yes	Yes	0	8	6
126	R:R:F188	R:R:F280	4.29	Yes	No	0	8	8
127	R:R:F188	R:R:L301	12.18	Yes	No	0	8	7
128	R:R:I189	R:R:Y196	6.04	Yes	Yes	0	6	6
129	R:R:I189	R:R:L197	7.14	Yes	No	0	6	7
130	R:R:R190	R:R:T194	5.17	No	No	0	5	3
131	R:R:H191	R:R:L197	3.86	No	No	0	6	7
132	R:R:H191	R:R:Q198	6.18	No	No	0	6	4
133	R:R:E288	R:R:H191	7.39	No	No	0	5	6
134	R:R:L204	R:R:Y200	10.55	No	Yes	0	7	7
135	R:R:F280	R:R:Y200	4.13	No	Yes	0	8	7
136	R:R:T202	R:R:Y285	4.99	No	No	0	4	5
137	R:R:L203	R:R:L207	5.54	No	No	0	5	7
138	R:R:L205	R:R:Y285	4.69	No	No	0	6	5
139	R:R:N215	R:R:V211	4.43	No	Yes	5	9	8
140	R:R:T270	R:R:V211	4.76	No	Yes	5	8	8
141	R:R:L266	R:R:N215	8.24	No	No	0	8	9
142	R:R:N215	R:R:T270	7.31	No	No	5	9	8
143	R:R:L263	R:R:V218	4.47	Yes	No	0	7	9
144	R:R:I219	R:R:L263	4.28	No	Yes	0	7	7
145	R:R:L222	R:R:L263	4.15	No	Yes	0	8	7
146	R:R:D261	R:R:T260	4.34	No	No	0	8	5
147	R:R:D261	R:R:V322	4.38	No	No	0	8	7
148	R:R:D261	R:R:M326	4.16	No	No	0	8	4
149	R:R:L265	R:R:L318	4.15	No	No	0	8	6
150	R:R:F273	R:R:M269	3.73	Yes	No	0	8	9
151	R:R:I310	R:R:T272	6.08	No	No	0	7	7
152	R:R:D311	R:R:F273	9.55	Yes	Yes	0	9	8
153	R:R:C276	R:R:N307	11.02	No	No	0	9	9
154	R:R:F303	R:R:P279	7.22	No	No	0	6	9
155	R:R:F280	R:R:F283	4.29	No	Yes	0	8	4
156	R:R:T281	R:R:Y285	6.24	No	No	0	7	5
157	R:R:I282	R:R:W296	4.7	No	Yes	0	6	3
158	R:R:F283	R:R:S291	5.28	Yes	No	0	4	1
159	R:R:F283	R:R:W296	4.01	Yes	Yes	0	4	3
160	R:R:D297	R:R:F283	8.36	No	Yes	0	6	4
161	R:R:E294	R:R:M286	4.06	No	No	0	3	4
162	R:R:N287	R:R:T289	10.24	No	No	0	6	3
163	R:R:N287	R:R:S290	4.47	No	No	0	6	2
164	R:R:E288	R:R:R292	11.63	No	No	0	5	1
165	R:R:E294	R:R:W296	4.36	No	Yes	0	3	3
166	R:R:Q299	R:R:W296	10.95	No	Yes	0	4	3
167	R:R:F303	R:R:Q299	7.03	No	No	0	6	4
168	L:L:?1	R:R:R302	15.56	Yes	No	0	0	8
169	L:L:?1	R:R:S305	9.11	Yes	No	1	0	8
170	R:R:I306	R:R:I310	5.89	No	No	0	4	7
171	R:R:D311	R:R:N307	14.81	Yes	No	0	9	9
172	L:L:?1	R:R:S308	8.1	Yes	No	0	0	8
173	R:R:P320	R:R:P321	5.84	No	No	0	7	7
174	R:R:L325	R:R:V322	4.47	No	No	0	5	7
175	R:R:L323	R:R:M326	4.24	No	No	0	7	4
176	R:R:G153	R:R:V156	3.68	No	No	0	7	4
177	R:R:F112	R:R:L99	3.65	No	No	0	5	4
178	R:R:F128	R:R:L207	3.65	No	No	0	6	7
179	R:R:F143	R:R:L136	3.65	No	No	0	4	5
180	R:R:F315	R:R:L265	3.65	No	No	0	9	8
181	R:R:L154	R:R:R150	3.64	No	No	0	5	4
182	R:R:G176	R:R:T194	3.64	No	No	0	8	3
183	R:R:N221	R:R:R224	3.62	No	No	0	6	5
184	R:R:A131	R:R:C214	3.61	No	No	0	9	7
185	R:R:A122	R:R:S164	3.42	No	No	0	7	7
186	R:R:A131	R:R:V211	3.39	No	Yes	0	9	8
187	R:R:A201	R:R:T281	3.36	No	No	0	7	7
188	R:R:L157	R:R:P158	3.28	No	No	0	7	3
189	R:R:H140	R:R:Y135	3.27	No	No	0	5	6
190	R:R:S149	R:R:S151	3.26	No	No	0	6	4
191	R:R:A237	R:R:M326	3.22	No	No	0	2	4
192	R:R:C83	R:R:L79	3.17	No	No	0	7	8
193	R:R:A274	R:R:L278	3.15	No	No	0	6	6
194	R:R:M124	R:R:S277	3.07	No	No	0	7	9
195	R:R:L206	R:R:S210	3	No	No	0	4	5
196	R:R:L40	R:R:V36	2.98	No	No	0	5	7
197	R:R:L43	R:R:V75	2.98	No	No	0	8	9
198	R:R:L205	R:R:V209	2.98	No	No	0	6	4
199	R:R:N221	R:R:S217	2.98	No	No	0	6	6
200	R:R:N39	R:R:V75	2.96	Yes	No	0	9	9
201	R:R:D12	R:R:T15	2.89	No	No	0	2	4
202	R:R:D311	R:R:T272	2.89	Yes	No	0	9	7
203	L:L:?1	R:R:I306	2.89	Yes	No	0	0	4
204	R:R:P320	R:R:R49	2.88	No	No	0	7	7
205	R:R:P320	R:R:R319	2.88	No	No	0	7	9
206	R:R:I41	R:R:L45	2.85	No	No	0	5	7
207	R:R:I208	R:R:L212	2.85	No	No	0	8	7
208	R:R:I268	R:R:L318	2.85	No	No	0	5	6
209	R:R:I317	R:R:L318	2.85	No	No	0	8	6
210	R:R:L19	R:R:N96	2.75	Yes	No	0	5	5
211	R:R:F303	R:R:V275	2.62	No	No	0	6	5
212	R:R:F315	R:R:L45	2.44	No	No	0	9	7
213	R:R:F119	R:R:L80	2.44	Yes	No	0	8	5
214	R:R:F119	R:R:L84	2.44	Yes	No	0	8	5
215	R:R:L102	R:R:R95	2.43	No	No	0	3	4
216	R:R:L298	R:R:R302	2.43	No	No	0	6	8
217	R:R:Q97	R:R:R95	2.34	No	No	0	3	4
218	R:R:F143	R:R:H140	2.26	No	No	0	4	5
219	R:R:G152	R:R:G153	2.11	No	No	0	5	7
220	R:R:P20	R:R:P21	1.95	Yes	No	0	2	1
221	R:R:A34	R:R:G35	1.95	No	No	0	6	9
222	R:R:A103	R:R:P104	1.87	Yes	No	0	5	3
223	R:R:A300	R:R:P279	1.87	No	No	0	7	9
224	R:R:A103	R:R:A108	1.79	Yes	No	6	5	5
225	R:R:A201	R:R:A284	1.79	No	No	0	7	5
226	R:R:P25	R:R:S24	1.78	No	No	0	5	6
227	R:R:P87	R:R:S86	1.78	No	No	0	7	8
228	R:R:G139	R:R:I138	1.76	No	Yes	0	7	8
229	R:R:G153	R:R:L66	1.71	No	No	0	7	6
230	R:R:G35	R:R:N39	1.7	No	Yes	0	9	9
231	R:R:A101	R:R:T98	1.68	No	No	0	3	4
232	R:R:E288	R:R:G192	1.64	No	No	0	5	3
233	R:R:L278	R:R:P279	1.64	No	No	0	6	9
234	R:R:S290	R:R:S291	1.63	No	No	0	2	1
235	R:R:A34	R:R:I309	1.62	No	No	0	6	9
236	R:R:A316	R:R:I41	1.62	No	No	0	9	5
237	R:R:A115	R:R:I85	1.62	No	No	0	5	6
238	R:R:A129	R:R:M126	1.61	No	Yes	0	7	8
239	R:R:S86	R:R:T82	1.6	No	No	0	8	8
240	R:R:S308	R:R:T82	1.6	No	No	0	8	8
241	R:R:V159	R:R:V163	1.6	No	No	0	3	3
242	R:R:T272	R:R:V314	1.59	No	No	0	7	8
243	R:R:A108	R:R:L99	1.58	No	No	0	5	4
244	R:R:A103	R:R:L102	1.58	Yes	No	6	5	3
245	R:R:A108	R:R:L102	1.58	No	No	6	5	3
246	R:R:A284	R:R:L197	1.58	No	No	0	5	7
247	R:R:I208	R:R:S277	1.55	No	No	0	8	9
248	R:R:I271	R:R:V275	1.54	No	No	0	6	5
249	R:R:H140	R:R:P141	1.53	No	No	0	5	9
250	R:R:K293	R:R:S290	1.53	No	No	0	3	2
251	R:R:A101	R:R:Q17	1.52	No	No	0	3	2
252	R:R:A195	R:R:Q198	1.52	No	No	0	5	4
253	R:R:L90	R:R:S29	1.5	No	No	0	7	4
254	R:R:L166	R:R:S169	1.5	No	No	0	3	5
255	R:R:L64	R:R:V69	1.49	No	No	0	6	7
256	R:R:L154	R:R:V69	1.49	No	No	0	5	7
257	R:R:L125	R:R:V163	1.49	Yes	No	0	6	3
258	R:R:L172	R:R:T110	1.47	No	No	0	4	4
259	R:R:I219	R:R:I223	1.47	No	No	0	7	5
260	R:R:L222	R:R:T260	1.47	No	No	0	8	5
261	R:R:I264	R:R:I268	1.47	No	No	0	6	5
262	R:R:I264	R:R:L263	1.43	No	Yes	0	6	7
263	R:R:I264	R:R:L325	1.43	No	No	0	6	5
264	R:R:A103	R:R:R107	1.38	Yes	No	0	5	2
265	R:R:R146	R:R:V148	1.31	No	No	0	5	5
266	R:R:L199	R:R:Y175	1.17	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L19	4.0875	4	1	5
2	R:R:P20	3.815	4	0	2
3	R:R:N39	6.635	4	0	9
4	R:R:F67	5.27	5	2	8
5	R:R:Y93	6.46833	6	1	7
6	R:R:A103	1.655	4	6	5
7	R:R:F118	7.258	5	0	7
8	R:R:F119	6.1575	4	0	8
9	R:R:L121	5.305	4	0	7
10	R:R:L125	4.9275	4	0	6
11	R:R:M126	3.89	4	0	8
12	R:R:E133	7.685	4	2	9
13	R:R:R134	8.8025	4	2	9
14	R:R:I138	4.77	4	2	8
15	R:R:Y178	8.205	4	0	6
16	R:R:Q180	6.7875	4	3	4
17	R:R:W186	8.818	5	1	7
18	R:R:F188	8.8075	4	0	8
19	R:R:I189	7.9325	4	0	6
20	R:R:Y196	7.7775	4	0	6
21	R:R:Y200	6.598	5	0	7
22	R:R:V211	4.635	4	5	8
23	R:R:L263	3.5825	4	0	7
24	R:R:F273	9.1425	4	0	8
25	R:R:F283	5.485	4	0	4
26	R:R:W296	6.005	4	0	3
27	R:R:D311	8.1425	4	0	9
28	L:L:?1	10.5775	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C182	R:R:G184	13.9307	3.92	No	No	0	3	5
2	R:R:G184	R:R:P20	15.2584	4.06	No	Yes	0	5	2
3	R:R:C182	R:R:Q180	11.2019	9.16	No	Yes	3	3	4
4	R:R:L19	R:R:P20	21.9741	4.93	Yes	Yes	0	5	2
5	R:R:L19	R:R:Y93	24.4745	4.69	Yes	Yes	1	5	7
6	L:L:?1	R:R:Y93	30.5593	3.95	Yes	Yes	1	0	7
7	L:L:?1	R:R:W186	53.0172	19.96	Yes	Yes	1	0	7
8	R:R:M116	R:R:W186	27.1221	5.82	No	Yes	0	7	7
9	R:R:F188	R:R:M116	26.9596	7.46	Yes	No	0	8	7
10	R:R:F188	R:R:F280	54.4765	4.29	Yes	No	0	8	8
11	R:R:F280	R:R:F283	43.4256	4.29	No	Yes	0	8	4
12	R:R:D297	R:R:F283	15.9667	8.36	No	Yes	0	6	4
13	R:R:D297	R:R:Y181	14.4029	9.2	No	No	0	6	8
14	R:R:L301	R:R:W186	27.0563	7.97	No	Yes	0	7	7
15	R:R:F188	R:R:L301	26.9131	12.18	Yes	No	0	8	7
16	L:L:?1	R:R:M31	15.7925	11.44	Yes	No	1	0	8
17	R:R:I309	R:R:M31	14.4339	7.29	No	No	0	9	8
18	L:L:?1	R:R:S308	10.1374	8.1	Yes	No	0	0	8
19	L:L:?1	R:R:I306	31.3296	2.89	Yes	No	0	0	4
20	R:R:I306	R:R:I310	30.8264	5.89	No	No	0	4	7
21	R:R:I310	R:R:T272	30.7645	6.08	No	No	0	7	7
22	R:R:D311	R:R:T272	31.4147	2.89	Yes	No	0	9	7
23	R:R:D311	R:R:D78	59.6013	5.32	Yes	No	0	9	9
24	R:R:D78	R:R:L74	58.5407	6.79	No	No	4	9	9
25	R:R:L74	R:R:M126	58.684	5.65	No	Yes	0	9	8
26	R:R:L70	R:R:M126	100	4.24	No	Yes	0	7	8
27	R:R:L70	R:R:M130	63.9675	7.07	No	No	0	7	9
28	R:R:F67	R:R:M130	62.8527	6.22	Yes	No	0	8	9
29	R:R:F67	R:R:L265	35.5293	6.09	Yes	No	0	8	8
30	R:R:F315	R:R:L265	13.8997	3.65	No	No	0	9	8
31	R:R:F315	R:R:L45	10.1026	2.44	No	No	0	9	7
32	R:R:A34	R:R:I309	13.025	1.62	No	No	0	6	9
33	R:R:A34	R:R:G35	11.6083	1.95	No	No	0	6	9
34	R:R:G35	R:R:N39	10.1839	1.7	No	Yes	0	9	9
35	R:R:L66	R:R:L70	35.1384	4.15	No	No	0	6	7
36	R:R:E133	R:R:L66	30.9657	5.3	Yes	No	0	9	6
37	R:R:E133	R:R:R134	28.3995	15.12	Yes	Yes	2	9	9
38	R:R:H262	R:R:R134	17.8556	7.9	No	Yes	0	8	9
39	R:R:H262	R:R:H68	15.5022	7.17	No	No	0	8	8
40	R:R:F67	R:R:R134	30.2535	4.28	Yes	Yes	2	8	9
41	R:R:H68	R:R:R49	10.1684	9.03	No	No	0	8	7
42	R:R:E73	R:R:M126	49.2859	4.06	No	Yes	0	7	8
43	R:R:E73	R:R:L157	48.6085	23.85	No	No	0	7	7
44	R:R:F280	R:R:Y200	64.761	4.13	No	Yes	0	8	7
45	R:R:L121	R:R:Y200	53.2224	7.03	Yes	Yes	0	7	7
46	R:R:L121	R:R:S164	58.7691	4.5	Yes	No	0	7	7
47	R:R:F118	R:R:S164	57.4144	7.93	Yes	No	0	7	7
48	R:R:F118	R:R:Y161	49.7465	6.19	Yes	No	0	7	7
49	L:L:?1	R:R:I85	21.2425	25.01	Yes	No	0	0	6
50	R:R:F112	R:R:I85	18.6956	6.28	No	No	0	5	6
51	R:R:F112	R:R:L99	16.3925	3.65	No	No	0	5	4
52	R:R:A108	R:R:L99	15.2584	1.58	No	No	0	5	4
53	R:R:F188	R:R:I189	34.1126	11.3	Yes	Yes	0	8	6
54	R:R:I189	R:R:Y178	12.0302	7.25	Yes	Yes	0	6	6
55	R:R:L121	R:R:L125	10.6019	5.54	Yes	Yes	0	7	6
56	R:R:I189	R:R:Y196	30.0871	6.04	Yes	Yes	0	6	6
57	R:R:F167	R:R:Y196	38.3046	4.13	No	Yes	0	6	6
58	R:R:F167	R:R:L203	19.1175	8.53	No	No	0	6	5
59	R:R:F167	R:R:Y200	28.1595	6.19	No	Yes	0	6	7
60	R:R:L121	R:R:L203	17.6272	4.15	Yes	No	0	7	5
61	R:R:L204	R:R:Y200	35.7383	10.55	No	Yes	0	7	7
62	R:R:D311	R:R:F273	37.7201	9.55	Yes	Yes	0	9	8
63	R:R:F273	R:R:M124	35.9783	7.46	Yes	No	0	8	7
64	R:R:L203	R:R:L207	10.8187	5.54	No	No	0	5	7
65	R:R:F128	R:R:L207	11.3644	3.65	No	No	0	6	7
66	R:R:R134	R:R:S137	39.1949	7.91	Yes	No	2	9	9
67	R:R:I138	R:R:S137	34.2442	6.19	Yes	No	2	8	9
68	R:R:I138	R:R:N221	29.0497	5.66	Yes	No	0	8	6
69	R:R:N221	R:R:S217	23.7778	2.98	No	No	0	6	6
70	R:R:S217	R:R:Y135	21.1303	5.09	No	No	0	6	6
71	R:R:H140	R:R:Y135	18.4749	3.27	No	No	0	5	6
72	R:R:F143	R:R:H140	13.1411	2.26	No	No	0	4	5
73	R:R:I189	R:R:L197	37.8788	7.14	Yes	No	0	6	7
74	R:R:H191	R:R:L197	15.4984	3.86	No	No	0	6	7
75	R:R:A284	R:R:L197	20.4529	1.58	No	No	0	5	7
76	R:R:A201	R:R:A284	17.5537	1.79	No	No	0	7	5
77	R:R:A201	R:R:T281	14.6468	3.36	No	No	0	7	7
78	R:R:T281	R:R:Y285	11.7321	6.24	No	No	0	7	5
79	R:R:L265	R:R:L318	21.6876	4.15	No	No	0	8	6
80	R:R:I268	R:R:L318	19.1368	2.85	No	No	0	5	6
81	R:R:I264	R:R:I268	17.7589	1.47	No	No	0	6	5
82	R:R:F283	R:R:W296	19.8684	4.01	Yes	Yes	0	4	3
83	R:R:Q299	R:R:W296	13.3578	10.95	No	Yes	0	4	3
84	R:R:F303	R:R:Q299	11.7128	7.03	No	No	0	6	4
85	R:R:L157	R:R:Y161	48.384	4.69	No	No	0	7	7
86	R:R:L204	R:R:M124	35.1732	4.24	No	No	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E23	R:R:L19	3.98	1	No	Yes	1	5	2	2
R:R:L19	R:R:Y93	4.69	1	Yes	Yes	5	7	2	1
R:R:E23	R:R:Y93	8.98	1	No	Yes	1	7	2	1
R:R:E23	R:R:T185	4.23	1	No	No	1	8	2	1
R:R:P25	R:R:Y93	11.13	0	No	Yes	5	7	2	1
R:R:I27	R:R:M31	4.37	1	No	No	4	8	1	1
L:L:?1	R:R:I27	4.81	1	Yes	No	0	4	0	1
R:R:S28	R:R:V89	4.85	1	No	No	7	7	1	1
L:L:?1	R:R:S28	9.11	1	Yes	No	0	7	0	1
R:R:I309	R:R:M31	7.29	0	No	No	9	8	2	1
L:L:?1	R:R:M31	11.44	1	Yes	No	0	8	0	1
R:R:F112	R:R:I85	6.28	0	No	No	5	6	2	1
L:L:?1	R:R:I85	25.01	1	Yes	No	0	6	0	1
L:L:?1	R:R:V89	9.04	1	Yes	No	0	7	0	1
R:R:S92	R:R:Y93	3.82	0	No	Yes	5	7	2	1
R:R:T185	R:R:Y93	6.24	1	No	Yes	8	7	1	1
L:L:?1	R:R:Y93	3.95	1	Yes	Yes	0	7	0	1
R:R:M116	R:R:W186	5.82	0	No	Yes	7	7	2	1
R:R:P183	R:R:W186	5.4	0	No	Yes	8	7	2	1
L:L:?1	R:R:T185	7.95	1	Yes	No	0	8	0	1
R:R:L301	R:R:W186	7.97	0	No	Yes	7	7	2	1
R:R:S305	R:R:W186	4.94	1	No	Yes	8	7	1	1
L:L:?1	R:R:W186	19.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R302	15.56	1	Yes	No	0	8	0	1
L:L:?1	R:R:S305	9.11	1	Yes	No	0	8	0	1
R:R:I306	R:R:I310	5.89	0	No	No	4	7	1	2
L:L:?1	R:R:S308	8.1	1	Yes	No	0	8	0	1
L:L:?1	R:R:I306	2.89	1	Yes	No	0	4	0	1
R:R:L298	R:R:R302	2.43	0	No	No	6	8	2	1
R:R:A115	R:R:I85	1.62	0	No	No	5	6	2	1
R:R:S308	R:R:T82	1.6	0	No	No	8	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
76.92	Single	9JRT	TG6-129	9JRT-EP₂-TG6-129
61.54	Single	9JQY	TG6-129	9JQY-EP₄-TG6-129
57.14	Single	9JQZ	Grapiprant	9JQZ-EP₄-Grapiprant
56.25	Single	6AK3	PGE2	6AK3-EP₃-PGE2
56.25	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
53.33	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
52.94	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
50.00	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
50.00	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
50.00	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
50.00	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
47.37	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
47.06	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
47.06	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
46.67	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
44.44	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.44	Single	9M1H	PGE2	9M1H-EP₁-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
44.44	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
44.44	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
43.75	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
43.75	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
43.75	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
43.75	Consensus	ep_off	Orthosteric Ligand	ep4_off
41.18	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
41.18	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
41.18	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
41.18	Single	9E9S	PGD2	9E9S-DP₁-PGD2-Gs/β1/γ1
38.89	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
36.84	Single	7D7M	PGE2	7D7M-EP₄-PGE2-Gs/β1/γ1
36.84	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
35.29	Single	9EE5	ONO-2550289	9EE5-DP₁-ONO-2550289
35.29	Single	9EKH	ONO-3030297	9EKH-DP₁-ONO-3030297
35.00	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41	Single	8GCM	L-902688	8GCM-EP₄-L-902688-Gi1/β1/γ2
27.78	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
27.78	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
26.67	Single	7XKF	Dehydroepiandrosterone	7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
25.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
25.00	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
25.00	Single	9BJK	PubChem 171642066	9BJK-μ-Naloxone-PubChem 171642066
23.81	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
22.22	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
22.22	Single	6KPF	AM12033	6KPF-CB₂-AM12033-Gi1/β1/γ2
22.22	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
21.05	Single	6KPC	AM12033	6KPC-CB₂-AM12033
21.05	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.05	Single	9B9Z	MRI-1867	9B9Z-CB₁-MRI-1867
21.05	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
20.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
20.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
20.00	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
20.00	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
20.00	Single	9RHG	C407	9RHG-FZD₇-C407
19.05	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
19.05	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
19.05	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
19.05	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
19.05	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
18.75	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
18.75	Single	6LI0	C17	6LI0-GPR52-C17
18.75	Single	8YKD	Dehydroepiandrosterone	8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
18.75	Single	9B9Y	Taranabant	9B9Y-CB₁-Taranabant
18.75	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg4_on
18.75	Consensus	adgrg_on_gp	Orthosteric Ligand	adgrg2_on_gp adgrg4_on_gp
18.52	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
18.18	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
18.18	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
17.86	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
17.65	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
17.65	Single	9K6L	Salicin	9K6L-TAS2R16-Salicin-Gi2/β1/γ2
16.67	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
16.67	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
16.67	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.67	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
16.67	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
16.67	Single	9BA0	MRI-1891	9BA0-CB₁-MRI-1891
16.67	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
16.67	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
15.79	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
15.79	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
15.79	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
15.79	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
15.00	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
15.00	Single	5T1A	BMS-681	5T1A-CCR2-BMS-681-PubChem 12093170
15.00	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
15.00	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
15.00	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
15.00	Single	9JKS	PubChem 44250176	9JKS-HCA₃-PubChem 44250176-Gi1/β1/γ2
15.00	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
15.00	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
15.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
14.81	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.81	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.81	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
14.29	Single	5V56	TC114	5V56-SMO-TC114
14.29	Single	5V57	TC114	5V57-SMO-TC114
14.29	Single	5XR8	AM12033	5XR8-CB₁-AM12033
14.29	Single	5XRA	AM11542	5XRA-CB₁-AM11542
14.29	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
14.29	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
14.29	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
14.29	Single	7XKD	Dehydroepiandrosterone	7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
14.29	Single	8WU1	MDMB-Fubinaca	8WU1-CB₁-MDMB-Fubinaca-Arrestin2
14.29	Single	8XQE	Apelin-13	8XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
14.29	Single	9EGO	Z8526711350	9EGO-CB₁-Z8526711350-Gi1/β1/γ2
14.29	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
13.79	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
13.79	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
13.64	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.64	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
13.64	Single	9WXM	GPR15L(CT)	9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
13.64	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
13.64	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
13.64	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
13.33	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
13.33	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33	Single	6P9X	Corticoliberin-1	6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
13.33	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.33	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
13.04	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
13.04	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
13.04	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Single	8GAG	Z8526711350	8GAG-CB₁-Z8526711350-Gi1/β1/γ2
13.04	Single	8WRZ	AM841	8WRZ-CB₁-AM841-Arrestin2
13.04	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
12.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
12.90	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
12.50	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
12.50	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.50	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
12.50	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
12.50	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
12.50	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
12.50	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
12.50	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
12.50	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
12.50	Single	8JEF	PubChem 11367166	8JEF-HCA₃-PubChem 11367166-Gi1/β1/γ2
12.50	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
12.50	Single	9IJR	C17	9IJR-GPR52-C17-Arrestin2
12.50	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9KT9	3,5-DHBA	9KT9-HCA₁-3,5-DHBA-Gi1/β1/γ2
12.50	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
12.50	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
12.12	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
12.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
12.00	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
12.00	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
12.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
12.00	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
12.00	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.76	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.76	Single	7LD3	MIPS521	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
11.76	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
11.76	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
11.76	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
11.76	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
11.76	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
11.76	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
11.76	Single	8W89	2-Phenylethylamine	8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
11.76	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
11.76	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
11.76	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
11.54	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
11.54	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
11.54	Single	7RKM	CX3CL1	7RKM-US28-CX3CL1-Gi1/β1/γ2
11.54	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
11.54	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
11.54	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.43	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.43	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
11.43	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
11.11	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
11.11	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
11.11	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
11.11	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
11.11	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
11.11	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
11.11	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
11.11	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
11.11	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
11.11	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
11.11	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
11.11	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
11.11	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
11.11	Single	8XZG	Apelin-13	8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
11.11	Single	8YFO	Ac-LA-PTH Analog	8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.11	Single	8Z87	CHBA	8Z87-HCA₁-CHBA-Gi1/β1/γ2
11.11	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
11.11	Single	9JKX	Acifran	9JKX-HCA₃-Acifran-Gi1/β1/γ2
11.11	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
11.11	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
11.11	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
11.11	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.11	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.11	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.11	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
11.11	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
11.11	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.11	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.81	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.81	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.81	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.71	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
10.71	Single	6NIY	Calcitonin-1	6NIY-CT-Calcitonin-1-Gs/β1/γ2
10.71	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
10.71	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.71	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
10.71	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.71	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
10.71	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
10.71	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
10.71	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
10.71	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
10.53	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
10.53	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
10.53	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
10.53	Single	6FFI	MPEP	6FFI-mGlu₅-MPEP
10.53	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
10.53	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
10.53	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
10.53	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
10.53	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
10.53	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
10.53	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.53	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
10.53	Single	8GUR	CP55940	8GUR-CB₂-CP55940-Gi1/β1/γ2
10.53	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
10.53	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
10.53	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
10.53	Single	8JEI	PubChem 11715556	8JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
10.53	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
10.53	Single	8JIM	Monomethyl fumarate	8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2
10.53	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
10.53	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
10.53	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
10.53	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
10.53	Single	9JH3	CMF-019	9JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
10.53	Single	9JKY	Acifran	9JKY-HCA₂-Acifran-Gi1/β1/γ2
10.53	Single	9ODJ	Mitragynine Pseudoindoxyl	9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
10.53	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
10.53	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
10.53	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
10.53	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
10.53	Consensus	hca_on	Orthosteric Ligand	hca2_on
10.53	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
10.53	Consensus	sensory_off	Orthosteric Ligand	opsins_off
10.34	Single	5YQZ	NNC1702	5YQZ-Glucagon-NNC1702
10.34	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
10.34	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
10.34	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.34	Single	7P02	Substance-P	7P02-NK₁-Substance-P-chim(NtGi1-Gs)/β1/γ2
10.34	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
10.34	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
10.34	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.34	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
10.34	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.34	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.34	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
10.00	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
10.00	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
10.00	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
10.00	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
10.00	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
10.00	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
10.00	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
10.00	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
10.00	Single	6NBI	LA-PTH Analog	6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
10.00	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
10.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
10.00	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
10.00	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
10.00	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
10.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
10.00	Single	7LJC	SKF81297	7LJC-D₁-SKF81297-Mevidalen-Gs/β1/γ2
10.00	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.00	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
10.00	Single	7VAB	Tirzepatide (non-acylated)	7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
10.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
10.00	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.00	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
10.00	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
10.00	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
10.00	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
10.00	Single	8JHN	Monomethyl fumarate	8JHN-HCA₂-Monomethyl fumarate-Go/β1/γ2
10.00	Single	8JII	Niacin	8JII-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
10.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
10.00	Single	8T1W	CVN424	8T1W-GPR6-CVN424
10.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
10.00	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.00	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
10.00	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
10.00	Single	8ZQE	GPR15L(CT)	8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
10.00	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
10.00	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.00	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
10.00	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
10.00	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
10.00	Consensus	a3_on	Orthosteric Ligand	a3a_on
10.00	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
10.00	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
10.00	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
10.00	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.00	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
10.00	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
10.00	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
10.00	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
10.00	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
10.00	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
10.00	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
10.00	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.00	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
9.68	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
9.68	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
9.68	Single	7EIB	Kallidin-des-Arg10	7EIB-BK₁-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
9.68	Single	7S1M	Exendin-4-D-Ala	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
9.68	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
9.68	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
9.68	Single	8FU6	ZP3780	8FU6-Glucagon-ZP3780-Gs/β1/γ2
9.68	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
9.68	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
9.68	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
9.68	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
9.68	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
9.68	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
9.68	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
9.68	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
9.52	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
9.52	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
9.52	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
9.52	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
9.52	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
9.52	Single	6GPX	MK0812	6GPX-CCR2-MK0812
9.52	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
9.52	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
9.52	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
9.52	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
9.52	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
9.52	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
9.52	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
9.52	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
9.52	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
9.52	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
9.52	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go/β1/γ2
9.52	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
9.52	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
9.52	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
9.52	Single	9HC0	4YI	9HC0-mGlu₅-4YI
9.52	Single	9KPF	Salicin	9KPF-TAS2R16-Salicin-Gi1/β1/γ2
9.52	Single	9KT6	Acifran	9KT6-HCA₃-Acifran-Gi1/β1/γ2
9.52	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
9.52	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.52	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.52	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
9.52	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
9.52	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
9.52	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
9.52	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
9.52	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
9.52	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.52	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.52	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
9.52	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
9.38	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.38	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
9.38	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.38	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
9.38	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
9.38	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.38	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
9.38	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.38	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
9.38	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
9.38	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
9.38	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
9.38	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
9.38	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
9.38	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
9.38	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
9.38	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
9.30	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09	Single	2YDV	NECA	2YDV-A_2A-NECA
9.09	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
9.09	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
9.09	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
9.09	Single	5G53	NECA	5G53-A_2A-NECA-Gs
9.09	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
9.09	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
9.09	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.09	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
9.09	Single	7P2L	4YI	7P2L-mGlu₅-4YI
9.09	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
9.09	Single	7U2L	C5-guano	7U2L-μ-C5-guano-Gi1/β1/γ2
9.09	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
9.09	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
9.09	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
9.09	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
9.09	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
9.09	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.09	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
9.09	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
9.09	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
9.09	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09	Single	8UGW	CGS21680	8UGW-A_2A-CGS21680
9.09	Single	8W8S	AA-14	8W8S-GPR101-AA-14
9.09	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.09	Single	8XZI	CMF-019	8XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
9.09	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
9.09	Single	9B65	MDMB-Fubinaca	9B65-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
9.09	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
9.09	Consensus	a2_on	Orthosteric Ligand	a2b_on
9.09	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
9.09	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
9.09	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
9.09	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
9.09	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
9.09	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.09	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.09	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.09	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
9.09	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
9.09	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
9.09	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
9.09	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
9.09	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
9.09	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
9.09	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
8.82	Single	6LPB	PACAP27	6LPB-PAC₁-PACAP27-Gs/β1/γ1
8.82	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
8.82	Single	8FLU	LA-PTH Analog	8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
8.82	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.82	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
8.82	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
8.82	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
8.70	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
8.70	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
8.70	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
8.70	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
8.70	Single	6H7N	Xamoterol	6H7N-β₁-Xamoterol
8.70	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.70	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
8.70	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.70	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
8.70	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
8.70	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
8.70	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
8.70	Single	8JJP	Chemerin-9	8JJP-CML2-Chemerin-9-Gi1/β1/γ2
8.70	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
8.70	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
8.70	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
8.70	Single	9M8P	Oleic monoethanolamide	9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
8.70	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
8.70	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.70	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
8.70	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
8.70	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
8.70	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
8.70	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
8.70	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
8.57	Single	6WPW	ZP3780	6WPW-Glucagon-ZP3780-Gs/β1/γ2
8.57	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.57	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
8.57	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.57	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
8.57	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
8.57	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
8.33	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
8.33	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
8.33	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
8.33	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
8.33	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
8.33	Single	7EZC	UK-432097	7EZC-A_2A-UK-432097
8.33	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
8.33	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
8.33	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
8.33	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
8.33	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
8.33	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
8.33	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
8.33	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Single	7Y36	PTH	7Y36-PTH1-PTH-Gs/β1/γ2
8.33	Single	8E0G	BU72	8E0G-μ-BU72
8.33	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
8.33	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
8.33	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
8.33	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
8.33	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
8.33	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
8.33	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
8.33	Single	8XGS	Kisspeptin-1	8XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
8.33	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
8.33	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
8.33	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
8.33	Single	9HYI	DP81	9HYI-5-HT_1A-DP81-Gi1/β1/γ2
8.33	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Single	9KT8	Acifran	9KT8-HCA₂-Acifran-Gi1/β1/γ2
8.33	Single	9KUG	EP67	9KUG-C5a₁-EP67-Go/β1/γ2
8.33	Single	9M54	Neuropeptide-VF	9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
8.33	Single	9UYH	Chemerin-9	9UYH-CML2-Chemerin-9-Arrestin2
8.33	Single	9UYM	Chemerin-9	9UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
8.33	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.33	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.33	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
8.33	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
8.33	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on adgrf_on adgrl_on adgre_on adgrd_on
8.33	Consensus	class-b2_on_gp	Orthosteric Ligand	adgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
8.33	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
8.11	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
8.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
8.00	Single	5VBL	AMG3054	5VBL-Apelin-AMG3054
8.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
8.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
8.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.00	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
8.00	Single	7RKF	CX3CL1	7RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
8.00	Single	7RKN	CX3CL1	7RKN-US28-CX3CL1-Gi1/β1/γ2
8.00	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
8.00	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
8.00	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
8.00	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
8.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
8.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
8.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
8.00	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.00	Single	8XZF	WN561	8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
8.00	Single	9CGK	C5-Quino	9CGK-δ-C5-Quino-Gi1/β1/γ2
8.00	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
8.00	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
8.00	Single	9M0R	Neuropeptide-VF	9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
8.00	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
8.00	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	4AMJ	Carvedilol	4AMJ-β₁-Carvedilol
7.69	Single	4XT1	CX3CL1	4XT1-US28-CX3CL1
7.69	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
7.69	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
7.69	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
7.69	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
7.69	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7.69	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
7.69	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
7.69	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
7.69	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
7.69	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
7.69	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
7.69	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.69	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
7.69	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
7.69	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
7.69	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
7.69	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
7.69	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
7.69	Single	9L3Y	Chemerin	9L3Y-CML2-Chemerin-Gi1/β1/γ2
7.69	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
7.69	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
7.69	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
7.69	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
7.69	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
7.69	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.50	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.41	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
7.41	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
7.41	Single	6DO1	(Sar1,Ile8)-Angiotensin II	6DO1-AT₁-(Sar1,Ile8)-Angiotensin II
7.41	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.41	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
7.41	Single	7PIV	Afamelanotide	7PIV-MC₄-Afamelanotide-Gs/β1/γ2
7.41	Single	7VBI	Tirzepatide (non-acylated)	7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
7.41	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
7.41	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
7.41	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
7.41	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41	Single	8JZZ	C5a-des-Arg	8JZZ-C5a₁-C5a-des-Arg-Go/β1/γ2
7.41	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
7.41	Single	8Z7J	JN241-9	8Z7J-Apelin-JN241-9-Gi1/β1/γ2
7.41	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
7.41	Single	9JFK	(Pen5)-Urotensin II	9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
7.41	Single	9KT7	MK6892	9KT7-HCA₂-MK6892-Gi1/β1/γ2
7.41	Single	9UMX	EP54	9UMX-C5a₁-EP54-Go/β1/γ2
7.41	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.41	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
7.41	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
7.41	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
7.41	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
7.41	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
7.32	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
7.14	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
7.14	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
7.14	Single	6VN7	PACAP27	6VN7-VPAC₁-PACAP27-Gs/β1/γ2
7.14	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
7.14	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
7.14	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
7.14	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.14	Single	9B54	VIP36	9B54-CB₁-VIP36-Gi1/β1/γ2
7.14	Single	9LXR	LA-PTH Analog	9LXR-PTH1-LA-PTH Analog-Arrestin2
7.14	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
7.14	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
7.14	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
7.14	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
7.14	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
6.90	Single	6M1I	PACAP27	6M1I-PAC₁-PACAP27-Gs/β1/γ2
6.90	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
6.90	Single	7F6G	(Sar1)-Angiotensin II	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
6.90	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.90	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
6.90	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
6.90	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.90	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
6.90	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
6.90	Single	8WST	MCH	8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90	Single	8X8L	Cortistatin-14	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.90	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
6.90	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90	Single	9BLC	Cagrilintide (non-acylated)	9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
6.90	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
6.90	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
6.90	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
6.90	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
6.90	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
6.90	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
6.90	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.90	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
6.90	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
6.90	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
6.67	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
6.67	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
6.67	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
6.67	Single	6VCB	LSN3160440	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.67	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
6.67	Single	7TYH	Calcitonin	7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
6.67	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
6.67	Single	7XKE	Dehydroepiandrosterone	7XKE-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.67	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
6.67	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
6.67	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
6.67	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.67	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.67	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
6.67	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
6.67	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
6.67	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
6.67	Single	8YG4	LA-PTH Analog	8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
6.67	Single	9JID	Niacin	9JID-HCA₃-Niacin-Gi1/β1/γ2
6.67	Single	9JKV	PubChem 2736690	9JKV-HCA₃-PubChem 2736690-Gi1/β1/γ2
6.67	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
6.67	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
6.67	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
6.67	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
6.67	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
6.67	Consensus	pac_on	Orthosteric Ligand	pac1_on
6.67	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.67	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
6.45	Single	4XT3	CX3CL1	4XT3-US28-CX3CL1
6.45	Single	6FJ3	PTH	6FJ3-PTH1-PTH
6.45	Single	6NBF	LA-PTH Analog	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
6.45	Single	6P9Y	PACAP27	6P9Y-PAC₁-PACAP27-Gs/β1/γ2
6.45	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
6.45	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.45	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
6.45	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.45	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
6.45	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45	Single	9BLB	Cagrilintide (non-acylated)	9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
6.45	Single	9BLW	Cagrilintide (non-acylated)	9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
6.45	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
6.45	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
6.45	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
6.45	Single	9P92	VIP	9P92-PAC₁-VIP-Gs/β1/γ2
6.45	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
6.45	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
6.45	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.45	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.45	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
6.45	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
6.45	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
6.25	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
6.25	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.25	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.25	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
6.25	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
6.25	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
6.25	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.25	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
6.25	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.25	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
6.25	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.25	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
6.25	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
6.25	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
6.25	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8IWM	2-Phenylethylamine	8IWM-TAA9-2-Phenylethylamine
6.25	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
6.25	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
6.25	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
6.25	Single	8Y02	All-trans-Retinal	8Y02-OPN1SW-All-trans-Retinal-Gi1/β1/γ2
6.25	Single	8Z8A	Lactate	8Z8A-HCA₁-Lactate-Gi1/β1/γ2
6.25	Single	8ZH8	QRFP26	8ZH8-QRFP-QRFP26-Gq/β1/γ1
6.25	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
6.25	Single	9EE9	Adenosine	9EE9-A_2A-Adenosine-Gs/β1/γ2
6.25	Single	9IVM	LSN3318839	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.25	Single	9M42	A1L8O	9M42-GPR139-A1L8O-chim(Gs-CtGq)/β1/γ2
6.25	Single	9P94	PACAP27	9P94-PAC₁-PACAP27-Gs/β1/γ2
6.25	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
6.25	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
6.25	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
6.25	Consensus	sensory_on	Orthosteric Ligand	opsins_on
6.06	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
6.06	Single	6NBH	LA-PTH Analog	6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
6.06	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.06	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
6.06	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
6.06	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.06	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
6.06	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
6.06	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
6.06	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
6.06	Single	9P93	VIP	9P93-PAC₁-VIP-Gs/β1/γ2
6.06	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.06	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.06	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
6.06	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
5.88	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.88	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
5.88	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
5.88	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
5.88	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
5.88	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.88	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
5.88	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
5.88	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
5.88	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
5.88	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.88	Single	6PWC	Neurotensin-(9-13)	6PWC-NTS₁-Neurotensin-(9-13)-Arrestin2
5.88	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.88	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/β1/γ2
5.88	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.88	Single	8ITF	DMCHA	8ITF-TAA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8IU2	All-trans-Retinal	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.88	Single	8IW7	2-Phenylethylamine	8IW7-TAA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8J6Q	PubChem 25101223	8J6Q-HCA₂-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
5.88	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/β1/γ2
5.88	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.88	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
5.88	Single	8Y6W	4-CMTB	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
5.88	Single	8YN9	Histamine	8YN9-H₄-Histamine-Gi1/β1/γ2
5.88	Single	8YUU	Histamine	8YUU-H₃-Histamine-Gi1/β1/γ1
5.88	Single	9JG1	Adriforant	9JG1-H₄-Adriforant
5.88	Single	9JHJ	C18:0 Ceramide	9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
5.88	Single	9JKT	(2R)-2-hydroxy-3-phenylpropanoic acid	9JKT-HCA₃-(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ2
5.88	Single	9LRC	Histamine	9LRC-H₄-Histamine
5.88	Single	9LRE	Histamine	9LRE-H₄-Histamine-Gi1/β1/γ2
5.88	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.88	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.88	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
5.88	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
5.88	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
5.88	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
5.88	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.88	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
5.88	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.88	Consensus	h3_on	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
5.88	Consensus	h3_on_gp	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
5.88	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.88	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.88	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
5.88	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
5.88	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
5.71	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
5.71	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.56	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
5.56	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
5.56	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
5.56	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
5.56	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
5.56	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
5.56	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.56	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
5.56	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.56	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
5.56	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.56	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
5.56	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
5.56	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.56	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.56	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2
5.56	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.56	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
5.56	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
5.56	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.56	Single	7XP6	Strychnine	7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.56	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
5.56	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.56	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
5.56	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
5.56	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
5.56	Single	8J6P	PubChem 25101223	8J6P-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
5.56	Single	8JHY	PubChem 25101223	8JHY-HCA₂-PubChem 25101223-Gi1/β1/γ2
5.56	Single	8JII	PubChem 25101223	8JII-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
5.56	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.56	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
5.56	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
5.56	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.56	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.56	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
5.56	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
5.56	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
5.56	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go/β1/γ2
5.56	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
5.56	Single	8ZYU	Neurotensin-(8-13)	8ZYU-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
5.56	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Single	9EPR	All-trans-Retinal	9EPR-Rhodopsin-All-trans-Retinal-Gi1/β1/γ2
5.56	Single	9IXJ	Histamine	9IXJ-H₂-Histamine-Gs/β1/γ2
5.56	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
5.56	Single	9JED	Histamine	9JED-H₄-Histamine-PO4-Gi1/β1/γ2
5.56	Single	9JEQ	Histamine	9JEQ-H₃-Histamine-Gi1/β1/γ2
5.56	Single	9JLC	AVE 0991	9JLC-MAS1-AVE 0991-Gi1/β1/γ2
5.56	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
5.56	Single	9L42	Histamine	9L42-H₄-Histamine-Gi1/β1/γ2
5.56	Single	9U9V	METH	9U9V-β₂-METH-Gs/β1/γ2
5.56	Single	9YDA	All-trans-Retinal	9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
5.56	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.56	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.56	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
5.56	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.56	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
5.56	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.56	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
5.56	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.56	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
5.41	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
5.41	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
5.26	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.26	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
5.26	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
5.26	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.26	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.26	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.26	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
5.26	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
5.26	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
5.26	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
5.26	Single	4BWB	Neurotensin-(8-12)	4BWB-NTS₁-Neurotensin-(8-12)
5.26	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
5.26	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
5.26	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
5.26	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
5.26	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
5.26	Single	5WS3	EMPA	5WS3-OX₂-EMPA
5.26	Single	6AKX	A4R	6AKX-CCR5-A4R
5.26	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.26	Single	6B73	MP1104	6B73-κ-MP1104
5.26	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.26	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
5.26	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
5.26	Single	6LFO	CXCL8	6LFO-CXCR2-CXCL8-Gi1/β1/γ2
5.26	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.26	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
5.26	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.26	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
5.26	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
5.26	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
5.26	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
5.26	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
5.26	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
5.26	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
5.26	Single	7EJ0	Norepinephrine	7EJ0-α_2a-Norepinephrine-Go/β1/γ2
5.26	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
5.26	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
5.26	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
5.26	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
5.26	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.26	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.26	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
5.26	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
5.26	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.26	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
5.26	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.26	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
5.26	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
5.26	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
5.26	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
5.26	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
5.26	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
5.26	Single	8DWG	ML382	8DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
5.26	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1
5.26	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
5.26	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
5.26	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
5.26	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
5.26	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
5.26	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
5.26	Single	8IW4	Spermidine	8IW4-TAA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8IWE	Spermidine	8IWE-TAA9-Spermidine
5.26	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
5.26	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
5.26	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
5.26	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
5.26	Single	8TZQ	Dopamine	8TZQ-D₂-Dopamine-Go/β1/γ2
5.26	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
5.26	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
5.26	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
5.26	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.26	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
5.26	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
5.26	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
5.26	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
5.26	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go/β1/γ2
5.26	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ2
5.26	Single	8YNF	CXCL8	8YNF-ACKR1-CXCL8
5.26	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
5.26	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
5.26	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
5.26	Single	9CLW	4-CMTB	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	9EBH	Adenosine	9EBH-A_3A-Adenosine-Gi1/β1/γ2
5.26	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
5.26	Single	9H2X	PubChem 175670644	9H2X-A_2A-PubChem 175670644-Na
5.26	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
5.26	Single	9KO2	CCL19	9KO2-CCR7-CCL19-Gi1/β1
5.26	Single	9KO6	CCL19	9KO6-CCR7-CCL19
5.26	Single	9KPE	Salicin	9KPE-TAS2R16-Salicin-Gi1/β1/γ2
5.26	Single	9KVH	Cinobufotenine	9KVH-5-HT_1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
5.26	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
5.26	Single	9PXU	Naloxone	9PXU-μ-Naloxone-Na
5.26	Single	9VJ5	Gepirone	9VJ5-5-HT_1A-Gepirone-Go/β1/γ2
5.26	Single	9VJE	Buspirone	9VJE-5-HT_1A-Buspirone-Go/β1/γ2
5.26	Single	9W49	U-50488H	9W49-κ-U-50488H-Gi1/β1/γ2
5.26	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.26	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
5.26	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
5.26	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
5.26	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
5.26	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.26	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.26	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
5.26	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.26	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
5.26	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
5.26	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.26	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
5.26	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
5.00	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
5.00	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
5.00	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
5.00	Single	4LDO	Epinephrine	4LDO-β₂-Epinephrine
5.00	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
5.00	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.00	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
5.00	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
5.00	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
5.00	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
5.00	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
5.00	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
5.00	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
5.00	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
5.00	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
5.00	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
5.00	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
5.00	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
5.00	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.00	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.00	Single	6IQL	L745870	6IQL-D₄-L745870
5.00	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
5.00	Single	6KUX	RS79948	6KUX-α_2a-RS79948
5.00	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.00	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
5.00	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.00	Single	6PS0	Carazolol	6PS0-β₂-Carazolol
5.00	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
5.00	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
5.00	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.00	Single	6TPG	EMPA	6TPG-OX₂-EMPA
5.00	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
5.00	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
5.00	Single	6VI4	JDTic	6VI4-κ-JDTic
5.00	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.00	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
5.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.00	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
5.00	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
5.00	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
5.00	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
5.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
5.00	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.00	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.00	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
5.00	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
5.00	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
5.00	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
5.00	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
5.00	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
5.00	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
5.00	Single	7F61	PF-03654746	7F61-H₃-PF-03654746
5.00	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
5.00	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.00	Single	7T94	LY2119620	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.00	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
5.00	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.00	Single	7UTZ	DPPC	7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
5.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
5.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
5.00	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
5.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
5.00	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.00	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GE5	Constrained Epinephrine	8GE5-β₂-Constrained Epinephrine-Gs/β1/γ1
5.00	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
5.00	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
5.00	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
5.00	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
5.00	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
5.00	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.00	Single	8JD6	VU0364770	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
5.00	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
5.00	Single	8K4N	PubChem 168719765	8K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
5.00	Single	8PM2	DMCHA	8PM2-TA7-DMCHA-Gs/β1/γ2
5.00	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
5.00	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
5.00	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
5.00	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
5.00	Single	8THK	A-61603	8THK-Alpha1A-A-61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8U02	Dopamine	8U02-D₂-Dopamine-Go/β1/γ2
5.00	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
5.00	Single	8Y01	All-trans-Retinal	8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
5.00	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
5.00	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
5.00	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
5.00	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
5.00	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
5.00	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
5.00	Single	8ZBW	Quin-C1	8ZBW-FPR2-ALX-Quin-C1-Gi2/β1/γ2
5.00	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
5.00	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
5.00	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9AS5	Mescaline	9AS5-5-HT_2A-Mescaline
5.00	Single	9AS6	Mescaline	9AS6-5-HT_2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
5.00	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
5.00	Single	9JMD	Azithromycin	9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
5.00	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
5.00	Single	9KPD	Salicin	9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
5.00	Single	9KVI	Bufotenin	9KVI-5-HT_1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
5.00	Single	9KXS	EP67	9KXS-C5a₁-EP67-Go/β1/γ2
5.00	Single	9LRD	Histamine	9LRD-H₁-Histamine-Gi1/β1/γ2
5.00	Single	9M2F	Neuropeptide-FF	9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
5.00	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
5.00	Single	9ODL	Mitragynine Pseudoindoxyl	9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
5.00	Single	9P1T	ZM-241385	9P1T-A_2A-ZM-241385
5.00	Single	9PXV	Naloxone	9PXV-μ-Naloxone-Gi1/β1/γ2
5.00	Single	9PXX	Naloxone	9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
5.00	Single	9PY2	Loperamide	9PY2-μ-Loperamide-GDPβS-Gi1/β1/γ2
5.00	Single	9VJG	8-OH-DPAT	9VJG-5-HT_1A-8-OH-DPAT-chim(NtGi2-Gz)/β1/γ2
5.00	Single	9VNF	Pindolol	9VNF-5-HT_1A-Pindolol-Go/β1/γ2
5.00	Single	9W33	S5A1	9W33-SST5-S5A1
5.00	Single	9W6W	5-CT	9W6W-5-HT_5A-5-CT-Gi1/β1/γ2
5.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
5.00	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA47070-Na 5N2R-A_2A-PSB36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-Etrumadenant-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-PubChem 984073-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
5.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
5.00	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
5.00	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.00	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
5.00	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.00	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.00	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
5.00	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
5.00	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
4.76	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
4.76	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
4.76	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
4.76	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
4.76	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
4.76	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
4.76	Single	3NYA	Alprenolol	3NYA-β₂-Alprenolol
4.76	Single	3ZPR	PubChem 598754	3ZPR-β₁-PubChem 598754-Na
4.76	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
4.76	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
4.76	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
4.76	Single	4GBR	Carazolol	4GBR-β₂-Carazolol
4.76	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
4.76	Single	4U16	N-methyl-Scopolamine	4U16-M₃-N-methyl-Scopolamine
4.76	Single	5DHG	C-35	5DHG-NOP-C-35
4.76	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
4.76	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
4.76	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
4.76	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
4.76	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
4.76	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
4.76	Single	5T04	Neurotensin-(8-13)	5T04-NTS₁-Neurotensin-(8-13)
4.76	Single	5UEN	DU172	5UEN-A₁-DU172
4.76	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
4.76	Single	5YC8	N-methyl-Scopolamine	5YC8-M₂-N-methyl-Scopolamine
4.76	Single	5ZK8	N-methyl-Scopolamine	5ZK8-M₂-N-methyl-Scopolamine
4.76	Single	5ZKC	N-methyl-Scopolamine	5ZKC-M₂-N-methyl-Scopolamine
4.76	Single	5ZKP	SR27417	5ZKP-PAF-SR27417
4.76	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
4.76	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
4.76	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
4.76	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
4.76	Single	6GPS	MK0812	6GPS-CCR2-MK0812
4.76	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
4.76	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
4.76	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
4.76	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
4.76	Single	6PRZ	Alprenolol	6PRZ-β₂-Alprenolol
4.76	Single	6PS1	Timolol	6PS1-β₂-Timolol
4.76	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
4.76	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
4.76	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	6Z4V	Neurotensin-(9-13)	6Z4V-NTS₁-Neurotensin-(9-13)
4.76	Single	7BTS	Epinephrine	7BTS-β₁-Epinephrine
4.76	Single	7BU6	Norepinephrine	7BU6-β₁-Norepinephrine
4.76	Single	7BU7	BI167107	7BU7-β₁-BI167107
4.76	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
4.76	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
4.76	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
4.76	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7JOZ	PubChem 75202022	7JOZ-D₁-PubChem 75202022-Gs/β1/γ2
4.76	Single	7M3J	NPS-2143; PO4	7M3J-CaS; CaS-NPS-2143; PO4
4.76	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
4.76	Single	7RBT	LSN3556672	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
4.76	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
4.76	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
4.76	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
4.76	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
4.76	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
4.76	Single	7VGZ	Ramelteon	7VGZ-MT₁-Ramelteon-Gi1/β1/γ2
4.76	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
4.76	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.76	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
4.76	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
4.76	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.76	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
4.76	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
4.76	Single	8GE2	Constrained Epinephrine	8GE2-β₂-Constrained Epinephrine-Gs/β1/γ1
4.76	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
4.76	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
4.76	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
4.76	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
4.76	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
4.76	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
4.76	Single	8IC0	CXCL8	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
4.76	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
4.76	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
4.76	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
4.76	Single	8JXR	LSD	8JXR-D₁-LSD
4.76	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
4.76	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.76	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-Gi1/β1/γ1
4.76	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
4.76	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
4.76	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
4.76	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
4.76	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
4.76	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
4.76	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
4.76	Single	8Y71	A1D6F	8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
4.76	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
4.76	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go/β1/γ2
4.76	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
4.76	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
4.76	Single	9CHX	Carazolol	9CHX-β₂-Carazolol
4.76	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
4.76	Single	9DYF	Asenapine	9DYF-5-HT_1A-Asenapine-PtdIns4P-Gi1/β1/γ2
4.76	Single	9H37	PubChem 175670646	9H37-A_2A-PubChem 175670646-Na
4.76	Single	9IMA	Talquetamab	9IMA-GPRC5D; GPRC5D-Talquetamab
4.76	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
4.76	Single	9JEA	Atropine	9JEA-M₁-Atropine
4.76	Single	9KFJ	PubChem 138319674	9KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
4.76	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
4.76	Single	9MET	Gp120; CD4	9MET-CXCR4-Gp120; CD4
4.76	Single	9P1S	ZM-241385	9P1S-A_2A-ZM-241385
4.76	Single	9PLN	PubChem 168259594	9PLN-α_2a-PubChem 168259594
4.76	Single	9PLO	PubChem 168259594	9PLO-α_2a-PubChem 168259594-Go/β1/γ2
4.76	Single	9PQD	PubChem 176491927	9PQD-α_2a-PubChem 176491927
4.76	Single	9PXW	Naloxone	9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
4.76	Single	9UAZ	Atropine	9UAZ-M₁-Atropine
4.76	Single	9VMY	TMU4142	9VMY-5-HT_1A-TMU4142-Go/β1/γ2
4.76	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
4.76	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
4.76	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
4.76	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
4.76	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
4.76	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
4.76	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
4.76	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
4.76	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
4.76	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
4.76	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
4.76	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Consensus	blt_on	Orthosteric Ligand	blt1_on
4.76	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
4.76	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
4.76	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
4.76	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
4.76	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
4.76	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
4.76	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
4.76	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
4.76	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
4.76	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
4.76	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
4.76	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
4.76	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
4.76	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
4.76	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
4.76	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
4.76	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.76	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
4.76	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
4.55	Single	2RH1	Carazolol	2RH1-β₂-Carazolol
4.55	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.55	Single	2YCW	Carazolol	2YCW-β₁-Carazolol
4.55	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
4.55	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
4.55	Single	5C1M	BU72	5C1M-μ-BU72
4.55	Single	5D6L	Carazolol	5D6L-β₂-Carazolol
4.55	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
4.55	Single	5JQH	Carazolol	5JQH-β₂-Carazolol
4.55	Single	5N2R	PSB36	5N2R-A_2A-PSB36-Na
4.55	Single	5N2S	PSB36	5N2S-A₁-PSB36
4.55	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
4.55	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
4.55	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
4.55	Single	5WQC	EMPA	5WQC-OX₂-EMPA
4.55	Single	5X7D	Carazolol	5X7D-β₂-Carazolol-PubChem 129318963
4.55	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
4.55	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
4.55	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
4.55	Single	6LFM	CXCL8	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
4.55	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
4.55	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.55	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
4.55	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
4.55	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.55	Single	6PS3	Carvedilol	6PS3-β₂-Carvedilol
4.55	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.55	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
4.55	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
4.55	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
4.55	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
4.55	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
4.55	Single	7BVQ	Carazolol	7BVQ-β₁-Carazolol
4.55	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
4.55	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
4.55	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
4.55	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
4.55	Single	7EPF	NAM597	7EPF-mGlu₂-NAM597
4.55	Single	7M3J	NPS-2143; PO4	7M3J-CaS; CaS-NPS-2143; PO4
4.55	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
4.55	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
4.55	Single	7SIN	NPS-2143	7SIN-CaS; CaS-NPS-2143
4.55	Single	7SIN	NPS-2143	7SIN-CaS; CaS-NPS-2143
4.55	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
4.55	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
4.55	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
4.55	Single	7W41	PD176252	7W41-BB₂-PD176252
4.55	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
4.55	Single	7WIG	L-054264	7WIG-SST2-L-054264-Gi1/β1/γ2
4.55	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
4.55	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
4.55	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
4.55	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
4.55	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
4.55	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
4.55	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
4.55	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
4.55	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
4.55	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
4.55	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
4.55	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
4.55	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
4.55	Single	8IZ4	Lysophosphatidylserine (TJR)	8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
4.55	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
4.55	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
4.55	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
4.55	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
4.55	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
4.55	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
4.55	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
4.55	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
4.55	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
4.55	Single	8ZMF	PubChem 171920673	8ZMF-5-HT_2C-PubChem 171920673
4.55	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8ZYT	Neurotensin-(8-13)	8ZYT-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
4.55	Single	9ARZ	2-bromo-LSD	9ARZ-5-HT_2A-2-bromo-LSD
4.55	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
4.55	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
4.55	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9DYD	Asenapine	9DYD-5-HT_1A-Asenapine-PtdIns4P-Go/β1/γ2
4.55	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
4.55	Single	9EHS	LUF7602	9EHS-A_3A-LUF7602
4.55	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
4.55	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go/β1/γ2
4.55	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
4.55	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
4.55	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
4.55	Single	9IYB	PGD2	9IYB-DP₂-PGD2-A1D5Q-Gi1/β1/γ2
4.55	Single	9KO4	CCL21	9KO4-CCR7-CCL21-Gi1/β1/γ2
4.55	Single	9KUT	JR14a	9KUT-C3a_B-JR14a-Go/β1/γ2
4.55	Single	9KUV	CMPD644	9KUV-Apelin-CMPD644-Arrestin2
4.55	Single	9L74	S1P d16:1	9L74-S1P₃-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
4.55	Single	9PXY	Naloxone	9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
4.55	Single	9VJF	Buspirone	9VJF-5-HT_1A-Buspirone-Gi3/β1/γ2
4.55	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.55	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.55	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
4.55	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
4.55	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
4.55	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.55	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
4.55	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
4.55	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
4.55	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
4.55	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
4.55	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
4.55	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
4.55	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.55	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
4.55	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
4.55	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.55	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
4.55	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-Carazolol 6PS3-β₂-Carvedilol 6PS5-β₂-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-PubChem 913103 6PRZ-β₂-Alprenolol
4.55	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.55	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
4.55	Consensus	blt_off	Orthosteric Ligand	blt1_off
4.55	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
4.55	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
4.55	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
4.55	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
4.55	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.55	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
4.55	Consensus	dp_off	Orthosteric Ligand	dp2_off
4.55	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
4.55	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
4.35	Single	3PDS	FAUC50	3PDS-β₂-FAUC50
4.35	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
4.35	Single	3ZEV	Neurotensin-(7-13)	3ZEV-NTS₁-Neurotensin-(7-13)
4.35	Single	4BV0	Neurotensin-(7-13)	4BV0-NTS₁-Neurotensin-(7-13)
4.35	Single	4DJH	JDTic	4DJH-κ-JDTic
4.35	Single	4LDL	Hydroxybenzyl Isoproterenol	4LDL-β₂-Hydroxybenzyl Isoproterenol
4.35	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
4.35	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
4.35	Single	5D5A	Carazolol	5D5A-β₂-Carazolol
4.35	Single	5D5B	Carazolol	5D5B-β₂-Carazolol
4.35	Single	5TZR	MK8666	5TZR-FFA1-MK8666
4.35	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
4.35	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.35	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
4.35	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.35	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
4.35	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
4.35	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
4.35	Single	6OS1	TRV026	6OS1-AT₁-TRV026
4.35	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
4.35	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.35	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
4.35	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
4.35	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
4.35	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.35	Single	7F1T	CCL3	7F1T-CCR5-CCL3
4.35	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
4.35	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
4.35	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
4.35	Single	7L0P	Neurotensin-(8-13)	7L0P-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
4.35	Single	7L0Q	Neurotensin-(8-13)	7L0Q-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
4.35	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
4.35	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
4.35	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
4.35	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
4.35	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
4.35	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.35	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
4.35	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
4.35	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.35	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
4.35	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.35	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
4.35	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	7XOW	Sulfated Gastrin-(10-17)	7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
4.35	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
4.35	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
4.35	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
4.35	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
4.35	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
4.35	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
4.35	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
4.35	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
4.35	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
4.35	Single	8FMZ	Neurotensin-(8-13)	8FMZ-NTS₁-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8FN1	Neurotensin-(8-13)	8FN1-NTS₁-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
4.35	Single	8HPT	C5a (C-terminal peptide)	8HPT-C5a₁-C5a (C-terminal peptide)-Go/β1/γ2
4.35	Single	8HQC	C5a	8HQC-C5a₁-C5a-Go/β1/γ2
4.35	Single	8I2G	PubChem 67530240	8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
4.35	Single	8I9L	C3a	8I9L-C3a_B-C3a-Go/β1/γ2
4.35	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
4.35	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
4.35	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
4.35	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.35	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
4.35	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.35	Single	8JZP	C5a	8JZP-C5a₁-C5a-Go/β1/γ2
4.35	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
4.35	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
4.35	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
4.35	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35	Single	8X0F	VU29	8X0F-mGlu5; mGlu5-Quisqualate-VU29
4.35	Single	8XBI	PubChem 162656636	8XBI-GPR34-PubChem 162656636
4.35	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
4.35	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
4.35	Single	9AS9	RS130-180	9AS9-5-HT_2A-RS130-180
4.35	Single	9ASA	RS130-180	9ASA-5-HT_2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
4.35	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
4.35	Single	9BJK	Naloxone	9BJK-μ-Naloxone-PubChem 171642066
4.35	Single	9BS9	LSD	9BS9-D₂-LSD
4.35	Single	9BSB	LSD	9BSB-D₂-LSD-chim(NtGi1-Go)/β1/γ2
4.35	Single	9I54	PubChem 176452091	9I54-D₁-PubChem 176452091-Gs/β1/γ2
4.35	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
4.35	Single	9IK9	Lanreotide	9IK9-SST1-Lanreotide-Gi1/β1/γ2
4.35	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
4.35	Single	9IZG	LPA	9IZG-LPA₁-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9JCL	ADP	9JCL-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
4.35	Single	9L16	CCL21	9L16-CCR7-CCL21
4.35	Single	9MEN	Gp120 (V3 loop)	9MEN-CXCR4-Gp120 (V3 loop)
4.35	Single	9PY3	Loperamide	9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
4.35	Single	9PY4	Loperamide	9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
4.35	Single	9UCP	Iperoxo	9UCP-M₁-Iperoxo-G11(CT)
4.35	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
4.35	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
4.35	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
4.35	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.35	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-PubChem 594590-Na 3ZPR-β₁-PubChem 598754-Na
4.35	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
4.35	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
4.35	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
4.35	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
4.35	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
4.35	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.35	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
4.35	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
4.35	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
4.35	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.35	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
4.35	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
4.35	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
4.35	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
4.35	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
4.35	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
4.35	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
4.35	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.17	Single	3D4S	Timolol	3D4S-β₂-Timolol
4.17	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
4.17	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.17	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
4.17	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.17	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
4.17	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
4.17	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
4.17	Single	4XEE	Neurotensin-(8-13)	4XEE-NTS₁-Neurotensin-(8-13)
4.17	Single	4XES	Neurotensin-(8-13)	4XES-NTS₁-Neurotensin-(8-13)
4.17	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
4.17	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
4.17	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.17	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
4.17	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.17	Single	6DRY	Methylergometrine	6DRY-5-HT_2B-Methylergometrine
4.17	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.17	Single	6OS0	Angiotensin II	6OS0-AT₁-Angiotensin II
4.17	Single	6OS2	TRV026	6OS2-AT₁-TRV026
4.17	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
4.17	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
4.17	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
4.17	Single	6YVR	Neurotensin-(6-13)	6YVR-NTS₁-Neurotensin-(6-13)
4.17	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
4.17	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.17	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
4.17	Single	7EO4	Siponimod	7EO4-S1P₁-Siponimod-Gi1/β1/γ2
4.17	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
4.17	Single	7EW2	FTY720-P	7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
4.17	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.17	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
4.17	Single	7L0S	Neurotensin-(8-13)	7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
4.17	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
4.17	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
4.17	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
4.17	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
4.17	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
4.17	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.17	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.17	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
4.17	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
4.17	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.17	Single	8DWC	BAM8-22	8DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
4.17	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1
4.17	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8HK2	C3a	8HK2-C3a_B-C3a-Gi1/β1/γ2
4.17	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.17	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8ID9	Icosapent	8ID9-FFA4-Icosapent-Gi1/β1/γ2
4.17	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.17	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
4.17	Single	8JJ8	Arformoterol	8JJ8-β₂-Arformoterol
4.17	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
4.17	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
4.17	Single	8JWY	2-118	8JWY-A_2A-2-118
4.17	Single	8U26	Substance-P	8U26-NK₁-Substance-P-Gs/β1/γ2
4.17	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
4.17	Single	8WRB	Lysophosphatidylserine (UBL)	8WRB-GPR34-Lysophosphatidylserine (UBL)-Gi1/β1/γ2
4.17	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17	Single	8XQJ	JN241	8XQJ-Apelin; Apelin-JN241
4.17	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.17	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.17	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
4.17	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
4.17	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
4.17	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
4.17	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
4.17	Single	9ECJ	S-geranylgeranyl-L-glutathione	9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
4.17	Single	9EK0	Iperoxo	9EK0-M₅-Iperoxo-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
4.17	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
4.17	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
4.17	Single	9KVG	5-MeO-DMT	9KVG-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
4.17	Single	9L3W	Chemerin	9L3W-CML1-Chemerin-Gi1/β1/γ2
4.17	Single	9V6O	Nalfurafine	9V6O-κ-Nalfurafine-Gi1/β1/γ2
4.17	Single	9VJ6	F-15599	9VJ6-5-HT_1A-F-15599-Gi3/β1/γ2
4.17	Single	9W32	SSTR5 antagonist 1	9W32-SST5-SSTR5 antagonist 1
4.17	Single	9WSW	Endomorphin	9WSW-μ-Endomorphin-chim(NtGi1-Gz)/β1/γ2
4.17	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
4.17	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
4.17	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
4.17	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
4.17	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.17	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
4.17	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.17	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
4.17	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
4.17	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.17	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.17	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
4.17	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
4.17	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.17	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
4.17	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
4.17	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
4.17	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.17	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
4.17	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
4.17	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
4.17	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
4.17	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
4.17	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
4.17	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.17	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
4.17	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.17	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.17	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00	Single	4BUO	Neurotensin-(8-13)	4BUO-NTS₁-Neurotensin-(8-13)
4.00	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
4.00	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.00	Single	5X93	K-8794	5X93-ET_B-K-8794
4.00	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.00	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
4.00	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.00	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.00	Single	6UP7	Neurotensin-(8-13)	6UP7-NTS₁-Neurotensin-(8-13)-Arrestin2
4.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
4.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
4.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
4.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
4.00	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
4.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
4.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.00	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
4.00	Single	7Y65	C5a (C-terminal peptide)	7Y65-C5a₁-C5a (C-terminal peptide)-Gi1/β1/γ2
4.00	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
4.00	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8FN0	Neurotensin-(8-13)	8FN0-NTS₁-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
4.00	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
4.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
4.00	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
4.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
4.00	Single	8JPF	Neurotensin-(8-13)	8JPF-NTS₁-Neurotensin-(8-13)-SBI-553
4.00	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
4.00	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.00	Single	8XBE	S3E-Lysophosphatidylserine	8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
4.00	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
4.00	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
4.00	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
4.00	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
4.00	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116
4.00	Single	8ZWG	JR14a	8ZWG-C3a_B-JR14a-Gi1/β1/γ2
4.00	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.00	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
4.00	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-PtdIns4P-Go/β1/γ2
4.00	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.00	Single	9J0B	UDP-Glucose	9J0B-P2Y₁₄-UDP-Glucose-Gi1/β1/γ2
4.00	Single	9KV8	TLQP21	9KV8-C3a_B-TLQP21-Go/β1/γ2
4.00	Single	9KWX	C5a-des-Arg	9KWX-C5a₁-C5a-des-Arg-Go/β1/γ2
4.00	Single	9WP9	S1P	9WP9-S1P₃-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.00	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
4.00	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
4.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
4.00	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
4.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
4.00	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
4.00	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.00	Consensus	endothelin_off	Orthosteric Ligand	etb_off
4.00	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
4.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.00	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.00	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
3.85	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
3.85	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
3.85	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
3.85	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
3.85	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
3.85	Single	7XN9	L-054522	7XN9-SST2-L-054522
3.85	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
3.85	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
3.85	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
3.85	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
3.85	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs/β1/γ2
3.85	Single	8SAI	Lysophosphatidylserine (S12)	8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
3.85	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
3.85	Single	8XQJ	JN241	8XQJ-Apelin; Apelin-JN241
3.85	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.85	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
3.85	Single	8Z74	JN241-9	8Z74-Apelin; Apelin-JN241-9
3.85	Single	8Z74	JN241-9	8Z74-Apelin; Apelin-JN241-9
3.85	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
3.85	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
3.85	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	9JF4	PD168368	9JF4-BB₁-PD168368
3.85	Single	9KX6	C5a-des-Arg	9KX6-C5a₁-C5a-des-Arg-Go/β1/γ2
3.85	Single	9KZ2	EP67	9KZ2-C3a_B-EP67-Go/β1/γ2
3.85	Single	9KZ8	EP67	9KZ8-C3a_B-EP67-Go/β1/γ2
3.85	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-PtdIns4P-Gz/β1/γ2
3.85	Single	9UMJ	EP54	9UMJ-C3a_B-EP54-Go/β1/γ2
3.85	Single	9WSX	Endomorphin	9WSX-μ-Endomorphin-Arrestin2
3.85	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
3.85	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.85	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
3.85	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
3.85	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.85	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
3.85	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
3.85	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
3.85	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
3.85	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
3.70	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
3.70	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
3.70	Single	7L0R	Neurotensin-(8-13)	7L0R-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
3.70	Single	7NA7	Ghrelin	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2
3.70	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
3.70	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.70	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
3.70	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	8DWG	BAM8-22	8DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.70	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
3.70	Single	8IEB	PubChem 134746894	8IEB-GPR156; GPR156-PubChem 134746894
3.70	Single	8IEI	PubChem 134746894	8IEI-GPR156; GPR156-PubChem 134746894
3.70	Single	8IEI	PubChem 134746894	8IEI-GPR156; GPR156-PubChem 134746894
3.70	Single	8IEP	PubChem 134746894	8IEP-GPR156; GPR156-PubChem 134746894
3.70	Single	8IEP	PubChem 134746894	8IEP-GPR156; GPR156-PubChem 134746894
3.70	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
3.70	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.70	Single	8XBH	PubChem 162656636	8XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
3.70	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
3.70	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
3.70	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
3.70	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
3.70	Single	8ZJD	Kisspeptin-1	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.70	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
3.70	Single	9KWG	C5a	9KWG-C5a₁-C5a-Go/β1/γ2
3.70	Single	9MEJ	Gp120	9MEJ-CXCR4-Gp120
3.70	Single	9UMR	C5a-pep	9UMR-C5a₁-C5a-pep-Go/β1/γ2
3.70	Single	9UYJ	Chemerin-9	9UYJ-CML2-Chemerin-9-Arrestin2
3.70	Single	9UYL	Chemerin-9	9UYL-CML2-Chemerin-9-Arrestin2
3.70	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.70	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.70	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
3.70	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
3.70	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.70	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.70	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.70	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.70	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
3.70	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
3.70	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
3.70	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
3.70	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.70	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.70	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
3.57	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7F1Q	CCL3	7F1Q-CCR5-CCL3-Gi1/β1/γ2
3.57	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
3.57	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
3.57	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.57	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
3.57	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	8IEB	PubChem 134746894	8IEB-GPR156; GPR156-PubChem 134746894
3.57	Single	8K6O	Neuropeptide-Y	8K6O-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.57	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.57	Single	8WSS	MCH	8WSS-MCH1-MCH-Gi1/β1/γ1
3.57	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
3.57	Single	9E82	CXCL12 (fragment)	9E82-ACKR3-CXCL12 (fragment)-Arrestin2
3.57	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
3.57	Single	9IK8	Pasireotide	9IK8-SST1-Pasireotide-Gi1/β1/γ2
3.57	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
3.57	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
3.57	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
3.57	Single	9KV6	TLQP21	9KV6-C3a_B-TLQP21-Go/β1/γ2
3.57	Single	9L60	Dynorphin	9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
3.57	Single	9ME1	CXCL12	9ME1-CXCR4-CXCL12
3.57	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.57	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
3.57	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.57	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
3.57	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.57	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
3.57	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
3.57	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
3.45	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
3.45	Single	6MEO	Gp160; CD4	6MEO-CCR5-Gp160; CD4
3.45	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.45	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.45	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
3.45	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
3.45	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
3.45	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
3.45	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.45	Single	8K6N	Neuropeptide-Y	8K6N-Y₂-Neuropeptide-Y-Gi2/β1/γ1
3.45	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.45	Single	8XZH	MM07	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
3.45	Single	9B5Y	LA-PTH Analog	9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
3.45	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
3.45	Single	9M1O	Neuropeptide-FF	9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
3.45	Single	9MEU	CXCL12	9MEU-CXCR4-CXCL12
3.45	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45	Single	9UYI	Chemerin-9	9UYI-CML2-Chemerin-9-Arrestin2
3.45	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
3.45	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
3.45	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
3.45	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.45	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
3.45	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
3.45	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.45	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
3.45	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.45	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.45	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
3.33	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.33	Single	6MET	Gp160; CD4	6MET-CCR5-Gp160; CD4
3.33	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.33	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
3.33	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
3.33	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	8IED	PubChem 134746894	8IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
3.33	Single	8IED	PubChem 134746894	8IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
3.33	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
3.33	Single	8XZJ	WN353	8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
3.33	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
3.33	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.33	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
3.33	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
3.33	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
3.33	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
3.33	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
3.23	Single	7F9Y	Ghrelin	7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.23	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.23	Single	7XV3	Lysophosphatidylserine (WJS)	7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7Y64	C5a	7Y64-C5a₁-C5a-Gi1/β1/γ2
3.23	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23	Single	8HK5	C5a	8HK5-C5a₁-C5a-Gi1/β1/γ2
3.23	Single	8IA2	C5a	8IA2-C5a₁-C5a-Go/β1/γ2
3.23	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.23	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.23	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.23	Single	8ZRT	Endothelin-1	8ZRT-ET_B-Endothelin-1
3.23	Single	9E2A	GLP-1	9E2A-GLP-1-GLP-1-Gs/β1/γ2
3.23	Single	9JFY	Neuropeptide-SF	9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
3.23	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
3.23	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
3.23	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.12	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
3.12	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
3.12	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
3.12	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
3.12	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
3.12	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
3.12	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
3.12	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
3.12	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
3.12	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.12	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.12	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
3.03	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.03	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
3.03	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
3.03	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
3.03	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.03	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.03	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.03	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
3.03	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.94	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
2.94	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.94	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
2.94	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
2.94	Single	8KGG	Lysophosphatidylserine (WJS)	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
2.94	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
2.94	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.86	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
2.86	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
2.86	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.86	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
2.86	Single	8ZJE	TAK448	8ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
2.86	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.86	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.86	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.86	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
2.86	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
2.78	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
2.78	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.78	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
2.78	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.63	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2

PDB Summary
PDB	9JRO
Class	A
SubFamily	Lipid
Type	Prostanoid
SubType	EP2
Species	Homo Sapiens
Ligand	PF-04418948
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.5
Date	2025-10-22
D.O.I.	To be published

Net Summary
I_min	3.73
Number of Linked Nodes	247
Number of Links	266
Number of Hubs	28
Number of Links mediated by Hubs	111
Number of Communities	6
Number of Nodes involved in Communities	29
Number of Links involved in Communities	35

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	55177
Length Of Smallest Path	3
Average Path Length	15.1679
Length of Longest Path	31
Minimum Path Strength	1.43
Average Path Strength	6.47431
Maximum Path Strength	18.225
Minimum Path Correlation	0.7
Average Path Correlation	0.908104
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	39.0365
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.8895
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • prostaglandin E receptor activity • prostanoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • response to ketone • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to progesterone • response to oxygen-containing compound • cell population proliferation • regulation of cell population proliferation • defense response • response to stress • inflammatory response • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to external biotic stimulus • response to nematode • response to biotic stimulus • response to lipopolysaccharide • response to bacterium • response to molecule of bacterial origin • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • periplasmic space • cell periphery • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43116
Sequence	>9JRO_Chain_R D C E T R Q W L P P G E S P A I S S V M F S A G V L G N L I A L A L L A R R L S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N Q T L V A L A P E S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H P Y F Y Q R R V S R S G G L A V L P V I Y A V S L L F C S L P L L D Y G Q Y V Q Y C P G T W C F I R H G R T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M N E T S S R K E K W D L Q A L R F L S I N S I I D P W V F A I L R P P V L R L M R S A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7CX2	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX2 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-	Gs/β1/γ2	2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-		2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268
	9JRT	A	Lipid	Prostanoid	EP₂	Homo sapiens	TG6-129	-	-	3.28	2025-10-22	To be published

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