Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.878515
2A:A:L36 3.3825417
3A:A:L37 5.175429
4A:A:K46 4.0825409
5A:A:I49 4.265487
6A:A:Q52 5.3725489
7A:A:M53 5.8525418
8A:A:F191 7.9325415
9A:A:L194 4.756514
10A:A:F196 8.78517
11A:A:M198 4.778517
12A:A:F199 8.48425
13A:A:V201 5.025429
14A:A:Q204 7.69429
15A:A:S206 5.1428
16A:A:R208 4.63509
17A:A:K210 5.81333629
18A:A:W211 6.85667629
19A:A:H213 7.13428
20A:A:F215 5.45167629
21A:A:I221 5.214528
22A:A:V225 4.025127
23A:A:L227 5.8454127
24A:A:D229 6.024108
25A:A:Y230 9.0945108
26A:A:D231 8.2285109
27A:A:M247 5.844146
28A:A:F250 6.96333609
29A:A:C254 5.36425
30A:A:W258 8.71833625
31A:A:F259 7.2625429
32A:A:I265 3.256508
33A:A:L266 4.8854129
34A:A:F267 6.416589
35A:A:L268 5.145128
36A:A:F274 7.1975409
37A:A:Y287 6.9745147
38A:A:Y290 9.96407
39A:A:Y302 10.63254146
40A:A:N311 5.02408
41A:A:Y320 9.294157
42A:A:H322 8.486589
43A:A:F323 4.60254124
44A:A:C325 3.2375407
45A:A:N331 8.952588
46A:A:F336 6.312518
47A:A:I343 5.128517
48A:A:N347 4.2625418
49A:A:C351 4.6575414
50A:A:F354 4.0954135
51B:B:L30 4.34535
52B:B:T34 5.57435
53B:B:V40 6.075433
54B:B:I43 3.34533
55B:B:M45 3.4225434
56B:B:L51 7.484559
57B:B:H54 9.87459
58B:B:I58 4.02659
59B:B:Y59 7.436528
60B:B:M61 3.7775456
61B:B:W63 6.24833657
62B:B:L70 4.68555
63B:B:V71 4.024178
64B:B:S72 5.3325459
65B:B:D76 4.6725409
66B:B:L79 4.6954177
67B:B:I80 9.58458
68B:B:W82 12.056559
69B:B:S84 5.185455
70B:B:N88 6.29407
71B:B:K89 7.03714759
72B:B:H91 5.275405
73B:B:I93 7.27407
74B:B:L95 3.9725408
75B:B:W99 8.034529
76B:B:Y105 3.995606
77B:B:N110 8.2054164
78B:B:V112 3.61254178
79B:B:I123 3.51626
80B:B:Y124 4.38667606
81B:B:L126 4.105405
82B:B:E138 6.21754186
83B:B:L139 6.7725409
84B:B:H142 6.67714729
85B:B:Y145 6.04333928
86B:B:F151 5.284529
87B:B:L152 5.4625443
88B:B:Q156 6.61445
89B:B:I157 4.855427
90B:B:T159 6.25429
91B:B:S161 7.005429
92B:B:D163 8.1125429
93B:B:C166 4.16448
94B:B:L168 5.472546
95B:B:W169 10.332528
96B:B:I171 3.56426
97B:B:F180 8.876547
98B:B:H183 6.6725849
99B:B:D186 5.332529
100B:B:V187 4.96549
101B:B:M188 5.5325428
102B:B:L190 4.25405
103B:B:A193 2.3325404
104B:B:F199 9.3375449
105B:B:S201 4.915449
106B:B:C204 6.238527
107B:B:D205 6.058549
108B:B:K209 9.276546
109B:B:W211 9.21667648
110B:B:C218 4.445445
111B:B:F222 7.2975468
112B:B:H225 8.17769
113B:B:D228 7.6125429
114B:B:I229 4.075467
115B:B:I232 5.4825468
116B:B:F235 5.20429796
117B:B:P236 5.295497
118B:B:F241 9.062566
119B:B:T243 5.1775468
120B:B:D247 6.628569
121B:B:T249 5.682566
122B:B:R251 9.09667668
123B:B:F253 6.7675466
124B:B:Q259 3.18406
125B:B:M262 5.625404
126B:B:T263 5.5525461
127B:B:Y264 5.445605
128B:B:F278 5.7625497
129B:B:R283 7.108539
130B:B:L284 4.3975435
131B:B:L285 5.1525496
132B:B:L286 3.62437
133B:B:Y289 7.701676117
134B:B:C294 4.09535
135B:B:N295 7.775116
136B:B:V296 3.8475435
137B:B:L300 5.35536
138B:B:K301 4.948505
139B:B:H311 8.54539
140B:B:L318 4.4675436
141B:B:T329 6.1675438
142B:B:W332 11.8871729
143B:B:D333 8.1675439
144B:B:K337 8.8275436
145B:B:W339 9.8639
146B:B:N340 6.44409
147G:G:L19 3.1475409
148G:G:Y40 9.6525496
149G:G:D48 7.35409
150G:G:L51 4.3875436
151G:G:P60 7.1125459
152G:G:F61 6.12286758
153L:L:R1 7.96143710
154R:R:P33 2.7075404
155R:R:I37 5.27476
156R:R:L55 6.485418
157R:R:F64 5.4975417
158R:R:Y67 7.916517
159R:R:F78 4.99833676
160R:R:Q82 5.58475
161R:R:I83 3.3075406
162R:R:F101 4.794504
163R:R:Y113 7.598578
164R:R:M119 4.496516
165R:R:L120 6.674519
166R:R:T122 4.515417
167R:R:R127 5.068519
168R:R:I135 3.5075416
169R:R:Y137 6.425617
170R:R:R141 5.36714718
171R:R:L160 4.65414
172R:R:F170 7.2025403
173R:R:F183 5.374214
174R:R:W190 6.828517
175R:R:I209 3.5654136
176R:R:L216 4.055134
177R:R:P217 3.76254135
178R:R:L221 3.63254138
179R:R:F232 8.3075409
180R:R:F239 7.208576
181R:R:Q242 7.765401
182R:R:W243 9.676504
183R:R:F244 7.03333615
184R:R:W248 6.89167603
185R:R:N271 5.562519
186R:R:N275 7.6675419
187R:R:Y279 5.08833619
188R:R:F280 5.54618
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:S316 25.06283.44NoNo079
2B:B:S316 B:B:W332 25.17154.94NoYes099
3A:A:W258 B:B:W332 24.86663.75YesYes259
4A:A:N256 A:A:W258 34.98494.52NoYes085
5A:A:I212 A:A:N256 35.08922.83NoNo088
6A:A:I212 A:A:R208 35.17763.76NoYes089
7A:A:L249 A:A:R208 97.133.64NoYes099
8A:A:F223 A:A:L249 97.22636.09NoNo099
9A:A:F223 A:A:F250 97.322716.08NoYes099
10A:A:F250 A:A:L266 32.97493.65YesYes099
11A:A:L266 A:A:L268 32.95385.54YesYes1298
12A:A:L227 A:A:L268 33.17286.92YesYes1278
13A:A:F274 A:A:L227 33.33038.53YesYes097
14A:A:F274 A:A:Y230 33.54176.19YesYes098
15A:A:D231 A:A:Y230 99.836722.99YesYes1098
16A:A:D231 A:A:L232 1002.71YesNo1098
17A:A:D229 A:A:L232 99.97195.43YesNo1088
18A:A:A226 A:A:D229 49.8926.18NoYes088
19A:A:A226 A:A:K270 49.88823.21NoNo089
20A:A:G45 A:A:K270 99.97241.74NoNo099
21A:A:G45 A:A:N269 99.94783.39NoNo099
22A:A:I49 A:A:N269 99.2992.83YesNo879
23A:A:F267 A:A:I49 99.14236.28YesYes897
24A:A:F267 A:A:I265 98.97773.77YesYes098
25A:A:I222 A:A:I265 98.36052.94NoYes078
26A:A:I222 A:A:L36 98.48372.85NoYes077
27A:A:L36 A:A:V34 49.40832.98YesYes175
28A:A:L194 A:A:V34 24.7214.47YesYes145
29A:A:I343 A:A:L194 49.11672.85YesYes174
30B:B:C317 B:B:M61 17.95353.24NoYes076
31A:A:F250 A:A:F307 33.02856.43YesNo098
32A:A:F307 A:A:M247 33.0236.22NoYes086
33A:A:M247 A:A:Y287 66.14045.99YesYes1467
34A:A:C286 A:A:Y287 66.3044.03NoYes067
35A:A:C286 A:A:Y230 66.36554.03NoYes068
36A:A:F250 A:A:L310 33.00994.87YesNo094
37A:A:L310 A:A:M247 33.19347.07NoYes046
38A:A:D229 A:A:S228 50.16172.94YesNo089
39A:A:K270 A:A:S228 50.1097.65NoNo099
40A:A:F196 A:A:L36 49.28244.87YesYes177
41A:A:F196 A:A:L194 24.77918.53YesYes174
42A:A:V339 A:A:V34 24.55296.41NoYes185
43A:A:I343 A:A:V339 49.08373.07YesNo178
44A:A:F196 A:A:V339 24.61075.24YesNo178
45A:A:R208 A:A:W211 63.85268YesYes099
46A:A:N347 R:R:Y137 57.72646.98YesYes187
47A:A:I343 A:A:N347 96.7644.25YesYes178
48A:A:W211 B:B:Y145 61.83565.79YesYes298
49B:B:L190 B:B:S160 12.11223YesNo056
50B:B:S147 B:B:S160 16.70664.89NoNo096
51A:A:K210 B:B:Y145 41.00763.58YesYes298
52A:A:K210 B:B:D228 20.56626.91YesYes299
53A:A:K210 B:B:D246 20.5665.53YesNo299
54A:A:N347 R:R:S130 38.70914.47YesNo188
55A:A:C351 R:R:S130 38.54263.44YesNo148
56A:A:C351 R:R:R127 63.29714.18YesYes149
57A:A:L353 R:R:R127 14.20217.29NoYes079
58A:A:C351 R:R:Y137 38.56414.03YesYes147
59A:A:C351 R:R:F64 13.47436.98YesYes147
60B:B:D228 B:B:S227 20.80845.89YesNo096
61B:B:D247 B:B:S227 41.04664.42YesNo096
62B:B:D247 B:B:H225 21.30065.04YesYes699
63B:B:H225 B:B:T243 11.53926.85YesYes698
64B:B:F222 B:B:F253 31.06774.29YesYes686
65B:B:F222 B:B:Q220 29.29578.2YesNo087
66B:B:D258 B:B:Q220 23.082710.44NoNo077
67B:B:D258 B:B:R22 20.419810.72NoNo076
68B:B:I18 B:B:R22 13.31813.76NoNo076
69B:B:I18 G:G:L19 10.65482.85NoYes079
70B:B:D246 B:B:S227 20.45884.42NoNo096
71B:B:F253 B:B:R251 25.29773.21YesYes668
72R:R:R127 R:R:Y279 48.54724.12YesYes199
73R:R:L120 R:R:Y279 44.17729.38YesYes199
74R:R:F232 R:R:L120 41.49016.09YesYes099
75R:R:F232 R:R:L117 39.49938.53YesNo098
76R:R:L117 R:R:Y113 35.46015.86NoYes088
77R:R:F239 R:R:Y113 13.524316.5YesYes768
78R:R:T122 R:R:Y67 16.17997.49YesYes177
79R:R:L153 R:R:T122 11.45934.42NoYes177
80R:R:L153 R:R:S118 11.14277.51NoNo178
81R:R:F78 R:R:Y113 17.59456.19YesYes768
82R:R:F64 R:R:V68 12.84323.93YesNo178
83R:R:F78 R:R:M109 12.18567.46YesNo764
84R:R:F81 R:R:M109 11.85894.98NoNo054
85R:R:F81 R:R:I84 11.18172.51NoNo055
86R:R:F101 R:R:I84 10.50452.51YesNo045
87B:B:S147 B:B:Y145 16.14543.82NoYes298
88B:B:M61 B:B:W63 10.71435.82YesYes567
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R1 R:R:C168 5.57 1 Yes No 0 6 0 1
L:L:R1 R:R:C180 4.18 1 Yes No 0 9 0 1
L:L:R1 R:R:W243 24.99 1 Yes Yes 0 4 0 1
L:L:R1 R:R:L247 6.07 1 Yes No 0 3 0 1
L:L:R1 R:R:W248 4 1 Yes Yes 0 3 0 1
L:L:P2 R:R:F170 10.11 0 No Yes 0 3 0 1
L:L:K3 R:R:L247 2.82 1 No No 0 3 0 1
R:R:F170 R:R:S103 6.61 0 Yes No 3 5 1 2
R:R:F170 R:R:T106 9.08 0 Yes No 3 5 1 2
R:R:C168 R:R:E164 3.04 1 No No 6 4 1 2
R:R:E164 R:R:F244 9.33 1 No Yes 4 5 2 2
R:R:C168 R:R:C180 7.28 1 No No 6 9 1 1
R:R:D174 R:R:G169 3.35 0 No No 2 1 2 1
R:R:F170 R:R:W243 3.01 0 Yes Yes 3 4 1 1
R:R:Q181 R:R:W248 18.62 0 No Yes 3 3 2 1
R:R:D184 R:R:F244 7.17 1 No Yes 3 5 2 2
R:R:D184 R:R:W248 8.93 1 No Yes 3 3 2 1
R:R:F185 R:R:W248 5.01 0 No Yes 3 3 2 1
R:R:F239 R:R:W243 3.01 7 Yes Yes 6 4 2 1
R:R:F244 R:R:W243 11.02 1 Yes Yes 5 4 2 1
R:R:H261 R:R:W243 6.35 0 No Yes 2 4 2 1
R:R:L247 R:R:L256 4.15 1 No No 3 2 1 2
R:R:S177 R:R:W248 2.47 0 No Yes 3 3 2 1
R:R:K251 R:R:W248 2.32 0 No Yes 1 3 2 1
L:L:P2 R:R:G169 2.03 0 No No 0 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
55.56Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
50.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
50.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
45.45Single7VV6C48/807VV6-MRGPRX2-C48/80
44.44Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
42.86Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
40.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
36.36Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
36.36Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
33.33Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
33.33Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
28.57Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
27.78Single8DWGBAM8-228DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.67Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
26.67Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
26.67Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
25.00Single8DWCBAM8-228DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
25.00Single9WXMGPR15L(CT)9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
23.53Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
23.53Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
23.08Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
22.22Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
22.22Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
22.22Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
22.22Single8PWNTheophylline8PWN-A2A-Theophylline
22.22Single9JF4PD1683689JF4-BB1-PD168368
21.43Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
21.05Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
21.05Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
21.05Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single7W41PD1762527W41-BB2-PD176252
20.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
20.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
20.00Single8K6ONeuropeptide-Y8K6O-Y1-Neuropeptide-Y-Gi2/β1/γ1
20.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
20.00Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
20.00Single9M42A1L8O9M42-GPR139-A1L8O-chim(Gs-CtGq)/β1/γ2
20.00Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
20.00Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
20.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.00Consensusbombesin_offOrthosteric Ligandbb2_off
19.05Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.05Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.05Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.75Single6J21Aprepitant6J21-NK1-Aprepitant
18.75Single7R0CAVP7R0C-V2-AVP-Arrestin2
18.75Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
18.75Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
18.75Single8I9LC3a8I9L-C3aB-C3a-Go/β1/γ2
18.75Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
18.75Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.18Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.18Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.18Single8J6QPubChem 251012238J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
18.18Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
17.65Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
17.65Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
17.65Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.65Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
17.65Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
17.65Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
17.65Single8ID9Icosapent8ID9-FFA4-Icosapent-Gi1/β1/γ2
17.65Single8JJPChemerin-98JJP-CML2-Chemerin-9-Gi1/β1/γ2
17.65Single8XQJJN2418XQJ-Apelin; Apelin-JN241
17.65Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
17.65Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.65Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.39Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.39Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
16.67Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
16.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.67Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
16.67Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
16.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
16.67Single8J6PPubChem 251012238J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
16.67Single8JHYPubChem 251012238JHY-HCA2-PubChem 25101223-Gi1/β1/γ2
16.67Single8JIIPubChem 251012238JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
16.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
16.67Single8XBES3E-Lysophosphatidylserine 8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single9J0BUDP-Glucose9J0B-P2Y14-UDP-Glucose-Gi1/β1/γ2
16.67Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9KUGEP679KUG-C5a1-EP67-Go/β1/γ2
16.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
16.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
16.67Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
16.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.00Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
15.79Single5VBLAMG3054 5VBL-Apelin-AMG3054
15.79Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
15.79Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
15.79Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
15.79Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
15.79Single8XQJJN2418XQJ-Apelin; Apelin-JN241
15.79Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
15.79Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
15.79Single9KZ2EP679KZ2-C3aB-EP67-Go/β1/γ2
15.38Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
15.38Single3PWHZM-2413853PWH-A2A-ZM-241385
15.38Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
15.38Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
15.38Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
15.38Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.38Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
15.38Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.38Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
15.38Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.38Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
15.38Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
15.38Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
15.38Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.38Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
15.38Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
15.38Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.38Single8GNGIstradefylline8GNG-A2A-Istradefylline
15.38Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
15.38Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
15.38Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
15.38Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
15.38Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
15.38Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
15.38Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
15.38Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.38Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
15.38Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
15.38Single9H2XPubChem 1756706449H2X-A2A-PubChem 175670644-Na
15.38Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
15.38Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
15.38Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
15.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
15.00Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
15.00Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
15.00Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
15.00Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
15.00Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
15.00Single8IZBLysophosphatidylserine (UBL)8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
15.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
15.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
15.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
15.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
15.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
14.81Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.81Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
14.81Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
14.29Single2YDOAdenosine2YDO-A2A-Adenosine
14.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
14.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
14.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.29Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
14.29Single5UVIZM-2413855UVI-A2A-ZM-241385
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.29Single6HLOAprepitant6HLO-NK1-Aprepitant
14.29Single6MH8ZM-2413856MH8-A2A-ZM-241385
14.29Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.29Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single7AROLUF58337ARO-A2A-LUF5833-Na
14.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
14.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
14.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
14.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
14.29Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8K4NPubChem 1687197658K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
14.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
14.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
14.29Single8WSSMCH8WSS-MCH1-MCH-Gi1/β1/γ1
14.29Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
14.29Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
14.29Single9IK8Pasireotide9IK8-SST1-Pasireotide-Gi1/β1/γ2
14.29Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
14.29Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
14.29Single9KXSEP679KXS-C5a1-EP67-Go/β1/γ2
14.29Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
14.29Single9P1TZM-2413859P1T-A2A-ZM-241385
14.29Single9U80Conivaptan9U80-V2-Conivaptan
14.29Single9W33S5A19W33-SST5-S5A1
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA47070-Na 5N2R-A2A-PSB36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-Etrumadenant-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-PubChem 984073-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
14.29Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
14.29Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
14.29Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
14.29Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.79Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
13.64Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
13.64Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
13.64Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
13.64Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
13.64Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
13.64Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single9UYIChemerin-99UYI-CML2-Chemerin-9-Arrestin2
13.64Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
13.64Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.64Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.64Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
13.64Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
13.33Single3EMLZM-2413853EML-A2A-ZM-241385
13.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
13.33Single4QIMANTA XV4QIM-SMO-ANTA XV
13.33Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
13.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.33Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.33Single5UENDU1725UEN-A1-DU172
13.33Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.33Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.33Single6S0LZM-2413856S0L-A2A-ZM-241385
13.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
13.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
13.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
13.33Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.33Single7JOZPubChem 752020227JOZ-D1-PubChem 75202022-Gs/β1/γ2
13.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
13.33Single7LJCSKF812977LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
13.33Single7PYRPSB-21157PYR-A2A-PSB-2115
13.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
13.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.33Single8CU6LJ-45178CU6-A2A-LJ-4517
13.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.33Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
13.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
13.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.33Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
13.33Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
13.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
13.33Single8XBGS3E-Lysophosphatidylserine 8XBG-GPR34-S3E-Lysophosphatidylserine
13.33Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
13.33Single8ZQEGPR15L(CT)8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
13.33Single9CHXCarazolol9CHX-β2-Carazolol
13.33Single9H37PubChem 1756706469H37-A2A-PubChem 175670646-Na
13.33Single9IYAONO-97105319IYA-GPR55-ONO-9710531
13.33Single9P1SZM-2413859P1S-A2A-ZM-241385
13.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.33Consensusa3_onOrthosteric Liganda3a_on
13.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
13.33Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
13.33Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
13.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
13.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
13.04Single6METGp160; CD46MET-CCR5-Gp160; CD4
13.04Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.04Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
13.04Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
13.04Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
13.04Single8WSTMCH8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
13.04Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
13.04Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
13.04Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
12.50Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.50Single5N2RPSB365N2R-A2A-PSB36-Na
12.50Single5N2SPSB365N2S-A1-PSB36
12.50Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
12.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
12.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.50Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
12.50Single6HLPNetupitant6HLP-NK1-Netupitant
12.50Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
12.50Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
12.50Single6S0QZM-2413856S0Q-A2A-ZM-241385
12.50Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
12.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
12.50Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
12.50Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
12.50Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
12.50Single7EPFNAM5977EPF-mGlu2-NAM597
12.50Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
12.50Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
12.50Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
12.50Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
12.50Single7WIGL-0542647WIG-SST2-L-054264-Gi1/β1/γ2
12.50Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.50Single7XV3Lysophosphatidylserine (WJS)7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
12.50Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
12.50Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
12.50Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.50Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
12.50Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
12.50Single8IZ4Lysophosphatidylserine (TJR)8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
12.50Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.50Single8S4DCMF-0198S4D-Apelin-CMF-019
12.50Single8TF5Oleic acid8TF5-GPR6-Oleic acid
12.50Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
12.50Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
12.50Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
12.50Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
12.50Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.50Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.50Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Single8ZRTEndothelin-18ZRT-ETB-Endothelin-1
12.50Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
12.50Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
12.50Single9EHSLUF76029EHS-A3A-LUF7602
12.50Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
12.50Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
12.50Single9L74S1P d16:19L74-S1P3-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
12.50Consensusa3_on_gpOrthosteric Liganda3a_on_gp
12.50Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
12.50Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
12.50Consensusadenosine_offOrthosteric Liganda1_off a2_off
12.50Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
12.50Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.50Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
12.50Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
12.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
12.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
11.76Single2YDVNECA2YDV-A2A-NECA
11.76Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
11.76Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
11.76Single4UHRCGS216804UHR-A2A-CGS21680
11.76Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
11.76Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
11.76Single5G53NECA5G53-A2A-NECA-Gs
11.76Single5V56TC1145V56-SMO-TC114
11.76Single5XRAAM115425XRA-CB1-AM11542
11.76Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.76Single6E59L-7607356E59-NK1-L-760735
11.76Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
11.76Single6J20Aprepitant6J20-NK1-Aprepitant
11.76Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
11.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
11.76Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.76Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
11.76Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
11.76Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
11.76Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
11.76Single7FEECP559407FEE-CB1-CP55940-ZCZ011
11.76Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
11.76Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
11.76Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
11.76Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
11.76Single7PX4PSB-21137PX4-A2A-PSB-2113
11.76Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
11.76Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
11.76Single7TUYGSK682753A7TUY-GPR183-GSK682753A
11.76Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
11.76Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
11.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7XOWSulfated Gastrin-(10-17)7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
11.76Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
11.76Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
11.76Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
11.76Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
11.76Single8HPTC5a (C-terminal peptide)8HPT-C5a1-C5a (C-terminal peptide)-Go/β1/γ2
11.76Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
11.76Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
11.76Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
11.76Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
11.76Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
11.76Single8UGWCGS216808UGW-A2A-CGS21680
11.76Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
11.76Single8XBIPubChem 1626566368XBI-GPR34-PubChem 162656636
11.76Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.76Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
11.76Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
11.76Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
11.76Single9B65MDMB-Fubinaca9B65-CB1-MDMB-Fubinaca-Gi1/β1/γ2
11.76Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single9I54PubChem 1764520919I54-D1-PubChem 176452091-Gs/β1/γ2
11.76Single9IK9Lanreotide9IK9-SST1-Lanreotide-Gi1/β1/γ2
11.76Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9RHGC4079RHG-FZD7-C407
11.76Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9YDVMRS29059YDV-P2Y14-MRS2905-Gi1/β1/γ2
11.76Consensusa2_onOrthosteric Liganda2b_on
11.76Consensusa2_on_gpOrthosteric Liganda2b_on_gp
11.76Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
11.76Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
11.76Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
11.76Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
11.76Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
11.76Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.76Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.76Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
11.76Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
11.76Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
11.76Consensuslpa_onOrthosteric Ligandlpa1_on
11.76Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
11.76Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusneurotensin_onOrthosteric Ligandnts1_on
11.76Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.76Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
11.76Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
11.76Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.76Consensustachykinin_offOrthosteric Ligandnk1_off
11.54Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
11.54Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.54Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
11.54Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
11.54Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
11.54Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
11.54Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.54Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.11Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
11.11Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
11.11Single4N4WSANT-14N4W-SMO-SANT-1
11.11Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
11.11Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.11Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
11.11Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
11.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
11.11Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.11Single6KQICP559406KQI-CB1-CP55940-Org27569
11.11Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
11.11Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.11Single7EO4Siponimod7EO4-S1P1-Siponimod-Gi1/β1/γ2
11.11Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
11.11Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
11.11Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
11.11Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
11.11Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.11Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8HK2C3a8HK2-C3aB-C3a-Gi1/β1/γ2
11.11Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
11.11Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
11.11Single8IY6Endothelin-18IY6-ETB-Endothelin-1
11.11Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
11.11Single8JWY2-1188JWY-A2A-2-118
11.11Single8KGGLysophosphatidylserine (WJS)8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
11.11Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
11.11Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
11.11Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
11.11Single8WRBLysophosphatidylserine (UBL)8WRB-GPR34-Lysophosphatidylserine (UBL)-Gi1/β1/γ2
11.11Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
11.11Single8XWACXCL18XWA-CXCR2-CXCL1
11.11Single8XWMCXCL68XWM-CXCR2-CXCL6
11.11Single8XWSCXCL58XWS-CXCR2-CXCL5
11.11Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
11.11Single9CM3TUG-13759CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
11.11Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
11.11Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
11.11Single9L3WChemerin9L3W-CML1-Chemerin-Gi1/β1/γ2
11.11Single9YDUUDP-Glucose9YDU-P2Y14-UDP-Glucose-Gi1/β1/γ2
11.11Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
11.11Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
11.11Consensusbradykinin_onOrthosteric Ligandbk2_on
11.11Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
11.11Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
11.11Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.11Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
11.11Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
11.11Consensusendothelin_onOrthosteric Ligandetb_on eta_on
11.11Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
11.11Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
11.11Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.11Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
11.11Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
11.11Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
11.11Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
11.11Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
11.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
11.11Consensuslpa_offOrthosteric Ligandlpa1_off
11.11Consensuslpl_offOrthosteric Ligands1p_off lpa_off
11.11Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
11.11Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
11.11Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
11.11Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
11.11Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.11Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
11.11Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
11.11Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
10.53Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
10.53Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
10.53Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
10.53Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
10.53Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
10.53Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
10.53Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
10.53Single7EZCUK-4320977EZC-A2A-UK-432097
10.53Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
10.53Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
10.53Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
10.53Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
10.53Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7Y65C5a (C-terminal peptide)7Y65-C5a1-C5a (C-terminal peptide)-Gi1/β1/γ2
10.53Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Single8E0GBU728E0G-μ-BU72
10.53Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
10.53Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.53Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
10.53Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
10.53Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
10.53Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8WRZAM8418WRZ-CB1-AM841-Arrestin2
10.53Single8XGSKisspeptin-18XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
10.53Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.53Single8XVUCXCL28XVU-CXCR2-CXCL2
10.53Single8XWFCXCL38XWF-CXCR2-CXCL3
10.53Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
10.53Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
10.53Single8ZPLHF511168ZPL-CXCR4-HF51116
10.53Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
10.53Single9M54Neuropeptide-VF9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
10.53Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
10.53Single9VI9RFRP-39VI9-NPFF1-RFRP-3-Gi1/β1/γ2
10.53Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
10.53Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
10.53Consensuscck_onOrthosteric Ligandccka_on cckb_on
10.53Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
10.53Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
10.53Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
10.53Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
10.53Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
10.34Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
10.34Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
10.34Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
10.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
10.00Single4UG2CGS216804UG2-A2A-CGS21680
10.00Single5WF6UK-4320975WF6-A2A-UK-432097
10.00Single5ZTYAM102575ZTY-CB2-AM10257
10.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
10.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
10.00Single6KNMJN241-96KNM-Apelin-JN241-9
10.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
10.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
10.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
10.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
10.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
10.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
10.00Single7XKDDehydroepiandrosterone7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
10.00Single7XKEDehydroepiandrosterone7XKE-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
10.00Single7XN9L-0545227XN9-SST2-L-054522
10.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
10.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
10.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
10.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
10.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
10.00Single8SAILysophosphatidylserine (S12)8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
10.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
10.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
10.00Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
10.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
10.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9KZ8EP679KZ8-C3aB-EP67-Go/β1/γ2
10.00Single9M0RNeuropeptide-VF9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
10.00Single9NS9TUG-13759NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
10.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
10.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
10.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
10.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
10.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
10.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
10.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
10.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
10.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
10.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.52Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.52Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
9.52Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
9.52Single7F8XNN90567F8X-CCKA-NN9056
9.52Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
9.52Single7NA7Ghrelin7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2
9.52Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
9.52Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
9.52Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.52Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
9.52Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
9.52Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
9.52Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
9.52Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.52Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
9.52Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
9.52Single8WDTphotoNECA8WDT-A2A-photoNECA
9.52Single8WKYPG-9348WKY-MC4-PG-934
9.52Single8XBHPubChem 1626566368XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
9.52Single8XWNCXCL88XWN-CXCR2-CXCL8
9.52Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
9.52Single8ZJDKisspeptin-18ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
9.52Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
9.52Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
9.52Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
9.52Single9MEJGp1209MEJ-CXCR4-Gp120
9.52Single9UMRC5a-pep9UMR-C5a1-C5a-pep-Go/β1/γ2
9.52Single9UYLChemerin-99UYL-CML2-Chemerin-9-Arrestin2
9.52Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.52Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.52Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
9.52Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
9.52Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
9.52Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
9.52Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
9.52Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
9.52Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
9.52Consensuslpl_onOrthosteric Ligands1p_on lpa_on
9.52Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
9.52Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
9.52Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.52Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.09Single3QAKUK-4320973QAK-A2A-UK-432097
9.09Single3RFMCaffeine3RFM-A2A-Caffeine
9.09Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
9.09Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
9.09Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
9.09Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
9.09Single7XNACYN1548067XNA-SST2-CYN154806
9.09Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
9.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
9.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
9.09Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
9.09Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
9.09Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
9.09Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
9.09Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
9.09Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
9.09Single9JFK(Pen5)-Urotensin II9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single9KV6TLQP219KV6-C3aB-TLQP21-Go/β1/γ2
9.09Single9L0HJR14a9L0H-C3aB-JR14a-Go/β1/γ2
9.09Single9L60Dynorphin9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
9.09Single9ME1CXCL129ME1-CXCR4-CXCL12
9.09Single9UMXEP549UMX-C5a1-EP54-Go/β1/γ2
9.09Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
9.09Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
9.09Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
9.09Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
9.09Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
9.09Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
9.09Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
9.09Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
9.09Consensusp2y_offOrthosteric Ligandp2y1_off
9.09Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
9.09Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
9.09Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
9.09Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
9.09Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
8.70Single3OE0CVX153OE0-CXCR4-CVX15
8.70Single5WF5UK-4320975WF5-A2A-UK-432097
8.70Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
8.70Single6W25SHU91196W25-MC4-SHU9119-Ca
8.70Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
8.70Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
8.70Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
8.70Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
8.70Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
8.70Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
8.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
8.70Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
8.70Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.70Single8XZGApelin-138XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
8.70Single9B54VIP369B54-CB1-VIP36-Gi1/β1/γ2
8.70Single9MEUCXCL129MEU-CXCR4-CXCL12
8.70Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.70Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
8.70Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
8.70Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
8.70Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
8.70Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
8.70Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
8.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
8.33Single3OE6IT1t3OE6-CXCR4-IT1t
8.33Single3UZAGTPL92363UZA-A2A-GTPL9236
8.33Single4XNWMRS25004XNW-P2Y1-MRS2500
8.33Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
8.33Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
8.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
8.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.33Single6PWCNeurotensin-(9-13)6PWC-NTS1-Neurotensin-(9-13)-Arrestin2
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
8.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
8.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
8.33Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
8.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
8.33Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
8.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
8.33Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
8.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
8.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
8.33Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
8.33Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
8.33Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
8.33Single8X8LCortistatin-148X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
8.33Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9IJRC179IJR-GPR52-C17-Arrestin2
8.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
8.33Single9KT93,5-DHBA9KT9-HCA1-3,5-DHBA-Gi1/β1/γ2
8.33Consensus5ht2_onOrthosteric Ligand5ht2b_on
8.33Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensusapelin_onOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
8.33Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
8.33Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
8.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.33Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.33Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
8.33Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
8.33Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
8.33Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
8.33Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
8.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
8.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
8.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
8.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
8.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
8.00Single5YQZNNC17025YQZ-Glucagon-NNC1702
8.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
8.00Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
8.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
8.00Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
8.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
8.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
8.00Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
8.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
8.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
8.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
8.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
8.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
8.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
8.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
8.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
8.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
8.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.69Single3OE9IT1t3OE9-CXCR4-IT1t
7.69Single3PBLEticlopride3PBL-D3-Eticlopride
7.69Single4O9RCyclopamine4O9R-SMO-Cyclopamine
7.69Single5L7IVismodegib5L7I-SMO-Vismodegib
7.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
7.69Single6HLLCP999946HLL-NK1-CP99994
7.69Single6LI0C176LI0-GPR52-C17
7.69Single6TP4ACT-4622066TP4-OX1-ACT-462206
7.69Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2
7.69Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
7.69Single7SK3CXCL127SK3-ACKR3-CXCL12
7.69Single7SRQLSD7SRQ-5-HT2B-LSD
7.69Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
7.69Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
7.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
7.69Single7XKFDehydroepiandrosterone7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
7.69Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
7.69Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
7.69Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
7.69Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.69Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
7.69Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
7.69Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.69Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
7.69Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
7.69Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
7.69Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
7.69Single8K5BNiacin8K5B-HCA2-Niacin
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.69Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
7.69Single8W892-Phenylethylamine8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
7.69Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
7.69Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
7.69Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
7.69Single8ZYUNeurotensin-(8-13)8ZYU-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
7.69Single9B9YTaranabant9B9Y-CB1-Taranabant
7.69Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
7.69Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
7.69Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
7.69Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
7.69Single9U9VMETH9U9V-β2-METH-Gs/β1/γ2
7.69Single9YDAAll-trans-Retinal9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
7.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
7.69Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
7.69Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.69Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
7.69Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
7.69Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.69Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.69Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
7.69Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
7.41Single7EIBKallidin-des-Arg107EIB-BK1-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7.41Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
7.41Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
7.41Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
7.41Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
7.41Single9KDFRES-701-39KDF-ETB-RES-701-3
7.41Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
7.41Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
7.41Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
7.41Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
7.14Single3ODUIT1t3ODU-CXCR4-IT1t
7.14Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
7.14Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
7.14Single4QINSAG1.54QIN-SMO-SAG1.5
7.14Single4S0VSuvorexant4S0V-OX2-Suvorexant
7.14Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
7.14Single5OLVLUAA470705OLV-A2A-LUAA47070-Na
7.14Single5U09Taranabant5U09-CB1-Taranabant
7.14Single5WS3EMPA5WS3-OX2-EMPA
7.14Single5ZKQABT-4915ZKQ-PAF-ABT-491
7.14Single6AKXA4R6AKX-CCR5-A4R
7.14Single6AKYMaraviroc6AKY-CCR5-Maraviroc
7.14Single6B73MP11046B73-κ-MP1104
7.14Single6DS0LY2660976DS0-5-HT2B-LY266097
7.14Single6IGLIRL16206IGL-ETB-IRL1620
7.14Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
7.14Single6ME2Ramelteon6ME2-MT1-Ramelteon
7.14Single6ME9Ramelteon6ME9-MT2-Ramelteon
7.14Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
7.14Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.14Single6TODEMPA6TOD-OX1-EMPA-Na
7.14Single6TPJSuvorexant6TPJ-OX2-Suvorexant
7.14Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
7.14Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
7.14Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
7.14Single7BR3Elagolix7BR3-GnRH1-Elagolix
7.14Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
7.14Single7EJ0Norepinephrine7EJ0-α2a-Norepinephrine-Go/β1/γ2
7.14Single7F8ULintitript7F8U-CCKA-Lintitript
7.14Single7F8YDevazepide7F8Y-CCKA-Devazepide
7.14Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
7.14Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
7.14Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
7.14Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
7.14Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
7.14Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
7.14Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
7.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
7.14Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
7.14Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
7.14Single7XRRLemborexant7XRR-OX2-Lemborexant
7.14Single8DWGML3828DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
7.14Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
7.14Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
7.14Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
7.14Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
7.14Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
7.14Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
7.14Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
7.14Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
7.14Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
7.14Single8TZQDopamine8TZQ-D2-Dopamine-Go/β1/γ2
7.14Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.14Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
7.14Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8YNFCXCL88YNF-ACKR1-CXCL8
7.14Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
7.14Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
7.14Single8Z87CHBA8Z87-HCA1-CHBA-Gi1/β1/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
7.14Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
7.14Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
7.14Single9JKXAcifran9JKX-HCA3-Acifran-Gi1/β1/γ2
7.14Single9K6LSalicin9K6L-TAS2R16-Salicin-Gi2/β1/γ2
7.14Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
7.14Single9KO6CCL199KO6-CCR7-CCL19
7.14Single9KPESalicin9KPE-TAS2R16-Salicin-Gi1/β1/γ2
7.14Single9LL9DOI9LL9-5-HT2A-DOI-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9LLBDOI-NBOMe9LLB-5-HT2A-DOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
7.14Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
7.14Single9PXUNaloxone9PXU-μ-Naloxone-Na
7.14Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
7.14Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
7.14Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
7.14Consensusalpha2_offOrthosteric Ligandalpha2c_off
7.14Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.14Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.14Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
7.14Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
7.14Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
7.14Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
7.14Consensusorexin_offOrthosteric Ligandox2_off ox1_off
7.14Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
7.14Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
7.14Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.14Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
7.14Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.90Single5GLHEndothelin-15GLH-ETB-Endothelin-1
6.90Single6IGKEndothelin-36IGK-ETB-Endothelin-3
6.90Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
6.90Single8ZJETAK4488ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
6.90Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.90Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.90Consensusbombesin_onOrthosteric Ligandbb2_on
6.90Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
6.90Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
6.90Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
6.90Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
6.67Single3REYPubChem 56973REY-A2A-PubChem 5697
6.67Single3RZECidoxepin3RZE-H1-Cidoxepin
6.67Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
6.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.67Single4LDOEpinephrine4LDO-β2-Epinephrine
6.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
6.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
6.67Single6IQLL7458706IQL-D4-L745870
6.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
6.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
6.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
6.67Single6PS0Carazolol6PS0-β2-Carazolol
6.67Single6PS4ICI118-5516PS4-β2-ICI118-551
6.67Single6PS5Propranolol6PS5-β2-Propranolol
6.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
6.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
6.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
6.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
6.67Single6TPGEMPA6TPG-OX2-EMPA
6.67Single6TPKRetosiban6TPK-OT-Retosiban
6.67Single6TPNHTL66416TPN-OX2-HTL6641
6.67Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.67Single6V9SGTPL114036V9S-OX1-GTPL11403
6.67Single6VI4JDTic6VI4-κ-JDTic
6.67Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
6.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
6.67Single6ZINSR486926ZIN-NTS1-SR48692
6.67Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
6.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
6.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
6.67Single7F61PF-036547467F61-H3-PF-03654746
6.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
6.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single7T32ZM-2413857T32-A2A-ZM-241385
6.67Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
6.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
6.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
6.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
6.67Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
6.67Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
6.67Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
6.67Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
6.67Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
6.67Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
6.67Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
6.67Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
6.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
6.67Single8GURCP559408GUR-CB2-CP55940-Gi1/β1/γ2
6.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
6.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
6.67Single8IHKAcifran8IHK-HCA3-Acifran
6.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
6.67Single8JEIPubChem 117155568JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
6.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
6.67Single8JIMMonomethyl fumarate8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2
6.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
6.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
6.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8K5CAcipimox8K5C-HCA2-Acipimox
6.67Single8K9KDAMGO8K9K-μ-DAMGO-Gi3/β1/γ1
6.67Single8K9LDAMGO8K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
6.67Single8RLNLUF58348RLN-A2A-LUF5834
6.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8U02Dopamine8U02-D2-Dopamine-Go/β1/γ2
6.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
6.67Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
6.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
6.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.67Single8Y01All-trans-Retinal8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
6.67Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
6.67Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
6.67Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
6.67Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
6.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.67Single9ARXSerotonin9ARX-5-HT2A-Serotonin
6.67Single9AS3LSD9AS3-5-HT2A-LSD
6.67Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AS5Mescaline9AS5-5-HT2A-Mescaline
6.67Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9BA0MRI-18919BA0-CB1-MRI-1891
6.67Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
6.67Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
6.67Single9JKYAcifran9JKY-HCA2-Acifran-Gi1/β1/γ2
6.67Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
6.67Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9K1DButyric acid9K1D-FFA2-Butyric acid-Gi1/β1/γ2
6.67Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
6.67Single9KPDSalicin9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
6.67Single9L84Epinephrine9L84-β1-Epinephrine-Atazanavir-Gs/β1/γ2
6.67Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
6.67Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
6.67Single9ODJMitragynine Pseudoindoxyl9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
6.67Single9ODLMitragynine Pseudoindoxyl9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
6.67Single9PXVNaloxone9PXV-μ-Naloxone-Gi1/β1/γ2
6.67Single9PXXNaloxone9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
6.67Single9W6W5-CT9W6W-5-HT5A-5-CT-Gi1/β1/γ2
6.67Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
6.67Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
6.67Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.67Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
6.67Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
6.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
6.67Consensusgrh_offOrthosteric Ligandgnrh1_off
6.67Consensushca_onOrthosteric Ligandhca2_on
6.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
6.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
6.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
6.67Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.67Consensussensory_offOrthosteric Ligandopsins_off
6.67Consensusvasop-oxy_offOrthosteric Ligandot_off
6.45Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
6.25Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
6.25Single2Y02Carmoterol2Y02-β1-Carmoterol
6.25Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
6.25Single3NY8ICI118-5513NY8-β2-ICI118-551
6.25Single3NYAAlprenolol3NYA-β2-Alprenolol
6.25Single3ZPQPubChem 5945903ZPQ-β1-PubChem 594590-Na
6.25Single3ZPRPubChem 5987543ZPR-β1-PubChem 598754-Na
6.25Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
6.25Single4EJ4Naltrindole4EJ4-δ-Naltrindole
6.25Single4GBRCarazolol4GBR-β2-Carazolol
6.25Single5DHGC-355DHG-NOP-C-35
6.25Single5DHHSB-6121115DHH-NOP-SB-612111
6.25Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
6.25Single5TGZAM65385TGZ-CB1-AM6538
6.25Single5UIGPubChem 1240811965UIG-A2A-PubChem 124081196
6.25Single6IIVDaltroban6IIV-TXA2-Daltroban
6.25Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.25Single6KPFAM120336KPF-CB2-AM12033-Gi1/β1/γ2
6.25Single6PRZAlprenolol6PRZ-β2-Alprenolol
6.25Single6PS1Timolol6PS1-β2-Timolol
6.25Single6PS2Alprenolol6PS2-β2-Alprenolol
6.25Single6TOTLemborexant6TOT-OX1-Lemborexant
6.25Single7BTSEpinephrine7BTS-β1-Epinephrine
6.25Single7BU6Norepinephrine7BU6-β1-Norepinephrine
6.25Single7BU7BI1671077BU7-β1-BI167107
6.25Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
6.25Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.25Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
6.25Single7NA8Ibutamoren7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
6.25Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
6.25Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
6.25Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
6.25Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
6.25Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
6.25Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
6.25Single7UL4Alvimopan7UL4-μ-Alvimopan
6.25Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
6.25Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
6.25Single7V3ZCP559407V3Z-CB1-CP55940
6.25Single7VGZRamelteon7VGZ-MT1-Ramelteon-Gi1/β1/γ2
6.25Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
6.25Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.25Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
6.25Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
6.25Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
6.25Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.25Single8EFQDAMGO8EFQ-μ-DAMGO-Gi1/β1/γ2
6.25Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8GCML-9026888GCM-EP4-L-902688-Gi1/β1/γ2
6.25Single8GE2Constrained Epinephrine8GE2-β2-Constrained Epinephrine-Gs/β1/γ1
6.25Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
6.25Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
6.25Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
6.25Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
6.25Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
6.25Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
6.25Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
6.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
6.25Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
6.25Single8J6PNiacin8J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
6.25Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
6.25Single8JHNMonomethyl fumarate8JHN-HCA2-Monomethyl fumarate-Go/β1/γ2
6.25Single8JIINiacin8JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
6.25Single8JJOAlprenolol8JJO-β2-Alprenolol
6.25Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.25Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
6.25Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
6.25Single8T1WCVN4248T1W-GPR6-CVN424
6.25Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
6.25Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.25Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
6.25Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
6.25Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
6.25Single8X63Mepyramine8X63-H1-Mepyramine
6.25Single8X64Desloratadine8X64-H1-Desloratadine
6.25Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
6.25Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
6.25Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
6.25Single8Y71A1D6F8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
6.25Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
6.25Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.25Single8ZYYNeurotensin-(8-13)8ZYY-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
6.25Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
6.25Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
6.25Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
6.25Single9IMATalquetamab9IMA-GPRC5D; GPRC5D-Talquetamab
6.25Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
6.25Single9JQZGrapiprant 9JQZ-EP4-Grapiprant
6.25Single9JROPF-044189489JRO-EP2-PF-04418948
6.25Single9LLAAriadne9LLA-5-HT2A-Ariadne-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single9METGp120; CD49MET-CXCR4-Gp120; CD4
6.25Single9PLNPubChem 1682595949PLN-α2a-PubChem 168259594
6.25Single9PLOPubChem 1682595949PLO-α2a-PubChem 168259594-Go/β1/γ2
6.25Single9PQDPubChem 1764919279PQD-α2a-PubChem 176491927
6.25Single9PXWNaloxone9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
6.25Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.25Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.25Consensus5ht5_onOrthosteric Ligand5ht5a_on
6.25Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.25Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.25Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.25Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
6.25Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
6.25Consensusalpha2_onOrthosteric Ligandalpha2b_on
6.25Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
6.25Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.25Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.25Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
6.25Consensuscck_offOrthosteric Ligandccka_off
6.25Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.25Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
6.25Consensusdopamine_offOrthosteric Ligandd2_off d3_off
6.25Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
6.25Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
6.25Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.25Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.25Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
6.25Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.25Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
6.25Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
6.25Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
6.25Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
6.25Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
6.25Consensushca_on_gpOrthosteric Ligandhca2_on_gp
6.25Consensushistamine_offOrthosteric Ligandh1_off
5.88Single2RH1Carazolol2RH1-β2-Carazolol
5.88Single2YCWCarazolol2YCW-β1-Carazolol
5.88Single4JKVTaladegib4JKV-SMO-Taladegib
5.88Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.88Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
5.88Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
5.88Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
5.88Single5C1MBU725C1M-μ-BU72
5.88Single5D6LCarazolol5D6L-β2-Carazolol
5.88Single5JQHCarazolol5JQH-β2-Carazolol
5.88Single5TVNLSD5TVN-5-HT2B-LSD
5.88Single5WQCEMPA5WQC-OX2-EMPA
5.88Single5X7DCarazolol5X7D-β2-Carazolol-PubChem 129318963
5.88Single5XPRBosentan5XPR-ETB-Bosentan
5.88Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
5.88Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
5.88Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
5.88Single6D26Fevipiprant6D26-DP2-Fevipiprant
5.88Single6E67BI1671076E67-β2-BI167107-Gs(CT)
5.88Single6KPCAM120336KPC-CB2-AM12033
5.88Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
5.88Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
5.88Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
5.88Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
5.88Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
5.88Single6PS3Carvedilol6PS3-β2-Carvedilol
5.88Single6PS6Timolol6PS6-β2-Timolol
5.88Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
5.88Single6TP6Filorexant6TP6-OX1-Filorexant
5.88Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.88Single6Z4SSR486926Z4S-NTS1-SR48692
5.88Single7BVQCarazolol7BVQ-β1-Carazolol
5.88Single7C61Ergotamine7C61-5-HT1B-Ergotamine
5.88Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
5.88Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.88Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
5.88Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.88Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
5.88Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
5.88Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
5.88Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
5.88Single7WC6LSD7WC6-5-HT2A-LSD
5.88Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
5.88Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
5.88Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
5.88Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.88Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.88Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
5.88Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
5.88Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.88Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
5.88Single8JXSPF-61428JXS-D1-PF-6142
5.88Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
5.88Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.88Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
5.88Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
5.88Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
5.88Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
5.88Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.88Single9B9ZMRI-18679B9Z-CB1-MRI-1867
5.88Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
5.88Single9EKHONO-30302979EKH-DP1-ONO-3030297
5.88Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
5.88Single9HAPTolvaptan9HAP-V2-Tolvaptan
5.88Single9HC04YI9HC0-mGlu5-4YI
5.88Single9IYBPGD29IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
5.88Single9JKSPubChem 442501769JKS-HCA3-PubChem 44250176-Gi1/β1/γ2
5.88Single9JRTTG6-1299JRT-EP2-TG6-129
5.88Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
5.88Single9KPFSalicin9KPF-TAS2R16-Salicin-Gi1/β1/γ2
5.88Single9KT6Acifran9KT6-HCA3-Acifran-Gi1/β1/γ2
5.88Single9KUTJR14a9KUT-C3aB-JR14a-Go/β1/γ2
5.88Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
5.88Single9PXYNaloxone9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
5.88Single9U81Tolvaptan9U81-V2-Tolvaptan
5.88Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.88Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.88Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.88Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
5.88Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.88Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
5.88Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
5.88Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
5.88Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
5.88Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
5.88Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
5.88Consensusamine_offonOrthosteric Ligandamine_off amine_on
5.88Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
5.88Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
5.88Consensusbeta2_offOrthosteric Ligand2RH1-β2-Carazolol 6PS3-β2-Carvedilol 6PS5-β2-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-PubChem 913103 6PRZ-β2-Alprenolol
5.88Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
5.88Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
5.88Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
5.88Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.88Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
5.88Consensusdp_offOrthosteric Liganddp2_off
5.88Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
5.88Consensusep_offOrthosteric Ligandep4_off
5.88Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.88Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
5.88Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
5.88Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
5.88Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.88Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.88Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.88Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.88Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
5.88Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
5.88Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
5.88Consensustrace-amine_onOrthosteric Ligandta1_on
5.56Single3P0GBI1671073P0G-β2-BI167107
5.56Single3PDSFAUC503PDS-β2-FAUC50
5.56Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
5.56Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
5.56Single4DJHJDTic4DJH-κ-JDTic
5.56Single5D5ACarazolol5D5A-β2-Carazolol
5.56Single5D5BCarazolol5D5B-β2-Carazolol
5.56Single5TZRMK86665TZR-FFA1-MK8666
5.56Single5V57TC1145V57-SMO-TC114
5.56Single5XR8AM120335XR8-CB1-AM12033
5.56Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
5.56Single6DDEDAMGO6DDE-μ-DAMGO-Gi1/β1/γ2
5.56Single6H7JIsoprenaline6H7J-β1-Isoprenaline
5.56Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
5.56Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
5.56Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
5.56Single6OS1TRV0266OS1-AT1-TRV026
5.56Single6TQ7SB-3348676TQ7-OX1-SB-334867
5.56Single6WGTLSD6WGT-5-HT2A-LSD
5.56Single7EW4CYM-55417EW4-S1P3-CYM-5541-Gi1/β1/γ2
5.56Single7F1TCCL37F1T-CCR5-CCL3
5.56Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
5.56Single7P2L4YI7P2L-mGlu5-4YI
5.56Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
5.56Single7U2LC5-guano7U2L-μ-C5-guano-Gi1/β1/γ2
5.56Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
5.56Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
5.56Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
5.56Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
5.56Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
5.56Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
5.56Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
5.56Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
5.56Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
5.56Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
5.56Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
5.56Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
5.56Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
5.56Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.56Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
5.56Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.56Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
5.56Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
5.56Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
5.56Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
5.56Single8WU1MDMB-Fubinaca8WU1-CB1-MDMB-Fubinaca-Arrestin2
5.56Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0FVU298X0F-mGlu5; mGlu5-Quisqualate-VU29
5.56Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
5.56Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
5.56Single8XVLZibotentan8XVL-ETA-Zibotentan
5.56Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
5.56Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
5.56Single8ZWFJR14a8ZWF-C3aB-JR14a
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.56Single9BJKNaloxone9BJK-μ-Naloxone-PubChem 171642066
5.56Single9BS9LSD9BS9-D2-LSD
5.56Single9BSBLSD9BSB-D2-LSD-chim(NtGi1-Go)/β1/γ2
5.56Single9E9SPGD29E9S-DP1-PGD2-Gs/β1/γ1
5.56Single9EGOZ85267113509EGO-CB1-Z8526711350-Gi1/β1/γ2
5.56Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
5.56Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
5.56Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
5.56Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
5.56Single9KVPSB2901579KVP-C3aB-SB290157-Go/β1/γ2
5.56Single9L16CCL219L16-CCR7-CCL21
5.56Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
5.56Single9PY3Loperamide9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
5.56Single9PY4Loperamide9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
5.56Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
5.56Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-PubChem 594590-Na 3ZPR-β1-PubChem 598754-Na
5.56Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
5.56Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
5.56Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.56Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.56Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
5.56Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
5.56Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.56Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
5.56Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
5.56Consensusrelaxin_onOrthosteric Ligandrxfp4_on
5.56Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
5.56Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
5.56Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
5.26Single3D4STimolol3D4S-β2-Timolol
5.26Single4AMIBucindolol4AMI-β1-Bucindolol
5.26Single4LDEBI1671074LDE-β2-BI167107
5.26Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.26Single4RWADIPP-NH24RWA-δ-DIPP-NH2
5.26Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
5.26Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
5.26Single6AK3PGE26AK3-EP3-PGE2
5.26Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
5.26Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
5.26Single6IIURamatroban6IIU-TXA2-Ramatroban
5.26Single6MXTSalmeterol6MXT-β2-Salmeterol
5.26Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
5.26Single6OS2TRV0266OS2-AT1-TRV026
5.26Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
5.26Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
5.26Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
5.26Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
5.26Single7EPENAM5637EPE-mGlu2-NAM563
5.26Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
5.26Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
5.26Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
5.26Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
5.26Single7YITNalfurafine7YIT-κ-Nalfurafine
5.26Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
5.26Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
5.26Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
5.26Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
5.26Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
5.26Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
5.26Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
5.26Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.26Single8JJ8Arformoterol8JJ8-β2-Arformoterol
5.26Single8JJLOlodaterol8JJL-β2-Olodaterol
5.26Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
5.26Single8JWZEtrumadenant8JWZ-A2A-Etrumadenant-Na
5.26Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
5.26Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.26Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.26Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
5.26Single9DGIZ85267113509DGI-CB1-Z8526711350
5.26Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single9KVG5-MeO-DMT9KVG-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
5.26Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
5.26Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
5.26Single9V6ONalfurafine9V6O-κ-Nalfurafine-Gi1/β1/γ2
5.26Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
5.26Single9W32SSTR5 antagonist 19W32-SST5-SSTR5 antagonist 1
5.26Single9WSVDAMGO9WSV-μ-DAMGO-Arrestin2
5.26Single9YDQDADLE9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
5.26Consensusalpha1_offOrthosteric Ligandalpha1a_off
5.26Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
5.26Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
5.26Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
5.26Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
5.26Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
5.26Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
5.26Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
5.26Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
5.26Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
5.26Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
5.26Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
5.26Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
5.26Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.26Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
5.26Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
5.26Consensusorexin_onOrthosteric Ligandox2_on
5.26Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
5.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
5.00Single5X93K-87945X93-ETB-K-8794
5.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
5.00Single6DDFDAMGO6DDF-μ-DAMGO-Gi1/β1/γ2
5.00Single6H7LDobutamine6H7L-β1-Dobutamine
5.00Single6IBLArformoterol6IBL-β1-Arformoterol
5.00Single6K1QIRL25006K1Q-ETB-IRL2500
5.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
5.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
5.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
5.00Single7D7MPGE27D7M-EP4-PGE2-Gs/β1/γ1
5.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
5.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
5.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
5.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
5.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
5.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
5.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
5.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
5.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8GAGZ85267113508GAG-CB1-Z8526711350-Gi1/β1/γ2
5.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
5.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
5.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
5.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
5.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
5.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8XVJMacitentan8XVJ-ETA-Macitentan
5.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
5.00Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
5.00Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
5.00Single9KT8Acifran9KT8-HCA2-Acifran-Gi1/β1/γ2
5.00Single9KV8TLQP219KV8-C3aB-TLQP21-Go/β1/γ2
5.00Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
5.00Single9M1HPGE29M1H-EP1-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9UYHChemerin-99UYH-CML2-Chemerin-9-Arrestin2
5.00Single9YDPDADLE9YDP-δ-DADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ2
5.00Single9YDRDADLE9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
5.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.00Consensuschemerin_onOrthosteric Ligandcml1_on
5.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
5.00Consensusendothelin_offOrthosteric Ligandetb_off
5.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
5.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
5.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
5.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
5.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
5.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
5.00Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.76Single6PT3DPI-2876PT3-δ-DPI-287
4.76Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
4.76Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
4.76Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
4.76Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.76Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
4.76Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
4.76Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
4.76Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
4.76Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
4.76Single8X5YAstemizole8X5Y-H1-Astemizole
4.76Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.76Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.76Single8XZFWN5618XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
4.76Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
4.76Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
4.76Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
4.76Single9IPYJR14a9IPY-C3aB-JR14a
4.76Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
4.76Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9KX6C5a-des-Arg9KX6-C5a1-C5a-des-Arg-Go/β1/γ2
4.76Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
4.76Single9WSXEndomorphin9WSX-μ-Endomorphin-Arrestin2
4.76Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
4.76Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
4.55Single4AMJCarvedilol4AMJ-β1-Carvedilol
4.55Single4IARErgotamine4IAR-5-HT1B-Ergotamine
4.55Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
4.55Single4XT1CX3CL14XT1-US28-CX3CL1
4.55Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
4.55Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
4.55Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
4.55Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.55Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
4.55Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
4.55Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
4.55Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
4.55Single8KIGSHU91198KIG-MC3-SHU9119-Ca
4.55Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
4.55Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
4.55Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.55Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
4.55Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
4.55Single9M4TSilodosin9M4T-Alpha1A-Silodosin
4.55Single9UYJChemerin-99UYJ-CML2-Chemerin-9-Arrestin2
4.55Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
4.55Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.55Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.55Consensussomatostatin_offOrthosteric Ligandsst2_off
4.55Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
4.35Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
4.35Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
4.35Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
4.35Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
4.35Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
4.35Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
4.35Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
4.35Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
4.35Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
4.35Single9E82CXCL12 (fragment)9E82-ACKR3-CXCL12 (fragment)-Arrestin2
4.35Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
4.35Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
4.35Single9KT7MK68929KT7-HCA2-MK6892-Gi1/β1/γ2
4.35Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
4.35Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
4.35Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.35Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
4.17Single6PT2KGCHM076PT2-δ-KGCHM07
4.17Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
4.17Single6VN7PACAP276VN7-VPAC1-PACAP27-Gs/β1/γ2
4.17Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
4.17Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
4.17Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
4.17Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
4.17Single9B5YLA-PTH Analog9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
4.17Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.17Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
4.17Consensusangiotensin_onOrthosteric Ligandat1_on
4.17Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
4.17Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
4.17Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
4.17Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
4.17Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
4.00Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
4.00Single6NIYCalcitonin-16NIY-CT-Calcitonin-1-Gs/β1/γ2
4.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
4.00Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
4.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
4.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
4.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
4.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
4.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
4.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
4.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
4.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
4.00Single9BLCCagrilintide (non-acylated)9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
4.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
4.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
4.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
4.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
4.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
4.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
4.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
4.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
3.85Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
3.85Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
3.85Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
3.85Single7TYHCalcitonin7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
3.85Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
3.85Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.85Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
3.85Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
3.85Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
3.85Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.85Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
3.85Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
3.85Consensuscalcitonin_onOrthosteric Ligandctlike_on
3.85Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
3.85Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
3.85Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.85Consensuspac_onOrthosteric Ligandpac1_on
3.85Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
3.85Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
3.70Single4XT3CX3CL14XT3-US28-CX3CL1
3.70Single6FJ3PTH6FJ3-PTH1-PTH
3.70Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
3.70Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
3.70Single6P9YPACAP276P9Y-PAC1-PACAP27-Gs/β1/γ2
3.70Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.70Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
3.70Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.70Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
3.70Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.70Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.70Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.70Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
3.70Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
3.70Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.70Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.70Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
3.70Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
3.70Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
3.70Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
3.70Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.70Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
3.70Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
3.70Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
3.70Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.70Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.70Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.70Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.70Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
3.70Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.70Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
3.70Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
3.57Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.57Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
3.57Single6P9XCorticoliberin-16P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
3.57Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
3.57Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.57Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.57Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
3.57Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.57Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
3.57Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
3.57Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
3.57Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
3.57Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
3.57Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
3.57Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
3.57Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
3.57Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.57Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
3.57Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
3.57Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
3.57Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
3.57Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
3.57Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.57Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
3.57Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.45Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
3.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.45Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.45Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
3.45Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
3.45Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.45Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
3.45Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
3.45Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.45Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
3.45Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.45Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
3.45Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.45Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
3.45Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.45Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
3.45Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.45Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
3.45Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
3.45Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
3.45Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
3.45Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.45Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.45Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
3.45Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
3.45Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
3.45Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
3.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
3.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.33Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
3.33Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
3.33Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.33Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.23Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
3.23Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.23Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.23Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.23Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.23Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
3.23Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.23Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
3.12Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
3.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.12Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.12Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.12Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.12Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
3.12Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
3.12Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
3.12Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.03Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.03Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.03Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
3.03Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.03Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.03Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.03Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.03Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
3.03Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
3.03Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.94Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.94Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.94Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.94Consensuspth_onOrthosteric Ligandpth1_on pth2_on
2.86Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.78Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.78Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.78Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.70Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.63Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.63Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
2.50Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp

PDB Summary
PDB 7VDM
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRX2
Species Homo Sapiens
Ligand Substance-P
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.98
Date 2021-12-01
D.O.I. doi.org/10.1038/s41586-021-04077-y
Net Summary
Imin 2.71
Number of Linked Nodes 812
Number of Links 1036
Number of Hubs 188
Number of Links mediated by Hubs 664
Number of Communities 21
Number of Nodes involved in Communities 277
Number of Links involved in Communities 423
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 15148889
Length Of Smallest Path 3
Average Path Length 46.235
Length of Longest Path 68
Minimum Path Strength 1.305
Average Path Strength 5.54121
Maximum Path Strength 25.52
Minimum Path Correlation 0.7
Average Path Correlation 0.997152
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 27.4177
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.7548
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • multicellular organismal process   • response to stress   • multicellular organismal response to stress   • response to pain   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • system process   • circulatory system process   • regulation of blood pressure   • blood circulation   • detection of stimulus   • response to abiotic stimulus   • detection of abiotic stimulus   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of acute inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • positive regulation of defense response   • regulation of acute inflammatory response   • inflammatory response   • acute inflammatory response   • positive regulation of cell communication   • modulation of chemical synaptic transmission   • positive regulation of synaptic transmission, GABAergic   • synaptic signaling   • positive regulation of cellular process   • trans-synaptic signaling   • regulation of signaling   • synaptic transmission, GABAergic   • positive regulation of synaptic transmission   • cell-cell signaling   • chemical synaptic transmission   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • positive regulation of signaling   • regulation of synaptic transmission, GABAergic   • cellular response to endogenous stimulus   • cellular response to growth factor stimulus   • response to endogenous stimulus   • cellular response to nerve growth factor stimulus   • response to nerve growth factor   • response to growth factor   • behavior   • learning or memory   • long-term memory   • nervous system process   • cognition   • memory   • regulation of action potential   • positive regulation of action potential   • action potential   • regulation of membrane potential   • positive regulation of cell population proliferation   • regulation of leukocyte activation   • regulation of cell activation   • lymphocyte activation   • leukocyte proliferation   • leukocyte activation   • positive regulation of lymphocyte activation   • positive regulation of cell activation   • lymphocyte proliferation   • positive regulation of leukocyte activation   • positive regulation of mononuclear cell proliferation   • regulation of immune system process   • regulation of multicellular organismal process   • positive regulation of immune system process   • regulation of lymphocyte proliferation   • regulation of leukocyte proliferation   • cell population proliferation   • cell activation   • positive regulation of lymphocyte proliferation   • regulation of cell population proliferation   • mononuclear cell proliferation   • immune system process   • positive regulation of leukocyte proliferation   • regulation of mononuclear cell proliferation   • positive regulation of multicellular organismal process   • regulation of lymphocyte activation   • learning   • associative learning   • ossification   • positive regulation of ossification   • regulation of ossification   • tachykinin receptor signaling pathway   • sensory perception   • sensory perception of pain   • heart process   • negative regulation of heart rate   • regulation of heart contraction   • regulation of system process   • negative regulation of biological process   • negative regulation of blood circulation   • negative regulation of heart contraction   • regulation of blood circulation   • heart contraction   • negative regulation of multicellular organismal process   • regulation of heart rate   • positive regulation of synaptic transmission, cholinergic   • synaptic transmission, cholinergic   • regulation of synaptic transmission, cholinergic   • multi-multicellular organism process   • reproductive process   • multicellular organismal reproductive process   • reproductive behavior   • insemination   • mating behavior   • multi-organism reproductive process   • copulation   • regulation of localization   • corticosterone secretion   • positive regulation of steroid hormone secretion   • localization   • regulation of glucocorticoid secretion   • positive regulation of glucocorticoid secretion   • regulation of steroid hormone secretion   • positive regulation of corticosteroid hormone secretion   • regulation of hormone levels   • lipid transport   • regulation of corticosteroid hormone secretion   • establishment of localization   • regulation of secretion   • endocrine hormone secretion   • positive regulation of lipid transport   • lipid export from cell   • glucocorticoid secretion   • regulation of endocrine process   • corticosteroid hormone secretion   • regulation of corticosterone secretion   • regulation of hormone secretion   • transport   • steroid hormone secretion   • regulation of lipid transport   • positive regulation of secretion by cell   • organic hydroxy compound transport   • hormone secretion   • positive regulation of corticosterone secretion   • secretion by cell   • positive regulation of hormone secretion   • regulation of secretion by cell   • positive regulation of secretion   • signal release   • secretion   • regulation of transport   • lipid localization   • export from cell   • positive regulation of lipid localization   • endocrine process   • positive regulation of transport   • regulation of lipid localization   • macromolecule localization   • hormone transport   • biological process involved in interspecies interaction between organisms   • response to lipid   • response to other organism   • response to oxygen-containing compound   • response to lipopolysaccharide   • response to biotic stimulus   • response to bacterium   • response to chemical   • response to external biotic stimulus   • response to molecule of bacterial origin   • positive regulation of organelle organization   • regulation of cytoskeleton organization   • regulation of cellular component organization   • regulation of actin filament-based process   • positive regulation of cellular component organization   • regulation of actin filament bundle assembly   • cellular component biogenesis   • cellular component organization   • cellular component assembly   • positive regulation of actin filament bundle assembly   • actin filament bundle organization   • positive regulation of stress fiber assembly   • actin filament-based process   • cellular component organization or biogenesis   • stress fiber assembly   • regulation of actin filament organization   • actin cytoskeleton organization   • actomyosin structure organization   • positive regulation of cellular component biogenesis   • positive regulation of cytoskeleton organization   • actin filament organization   • regulation of cellular component biogenesis   • positive regulation of supramolecular fiber organization   • regulation of organelle organization   • regulation of stress fiber assembly   • organelle organization   • contractile actin filament bundle assembly   • regulation of actomyosin structure organization   • regulation of actin cytoskeleton organization   • actin filament bundle assembly   • regulation of supramolecular fiber organization   • supramolecular fiber organization   • cytoskeleton organization   • response to hormone   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • positive regulation of epithelial cell migration   • tissue migration   • ameboidal-type cell migration   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • epithelial cell migration   • cell motility   • regulation of epithelial cell migration   • locomotion   • epithelium migration   • regulation of locomotion   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cellular anatomical structure   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle
Gene OntologyCellular Component• membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cellular anatomical structure   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • extracellular region   • synapse   • cell junction   • somatodendritic compartment   • cell body   • neuronal cell body   • axon   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • extracellular space   • binding   • neuropeptide binding   • peptide binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • mast cell secretagogue receptor activity   • G protein-coupled opioid receptor activity   • multicellular organismal process   • sleep   • response to stimulus   • response to stress   • multicellular organismal response to stress   • response to pain   • regulation of cytokinesis   • regulation of biological process   • regulation of cellular process   • positive regulation of cell division   • regulation of cell cycle process   • biological regulation   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cellular process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of macromolecule metabolic process   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of chemokine production   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • chemokine production   • positive regulation of chemokine production   • positive regulation of multicellular organismal process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • establishment of organelle localization   • regulated exocytosis   • cellular localization   • transport   • cell activation involved in immune response   • leukocyte degranulation   • myeloid leukocyte activation   • myeloid leukocyte mediated immunity   • vesicle-mediated transport   • leukocyte activation   • localization   • secretion by cell   • organelle localization   • leukocyte activation involved in immune response   • establishment of localization in cell   • mast cell activation   • leukocyte mediated immunity   • mast cell mediated immunity   • immune response   • secretion   • cell activation   • vacuolar localization   • export from cell   • mast cell degranulation   • establishment of localization   • myeloid cell activation involved in immune response   • immune effector process   • mast cell activation involved in immune response   • exocytosis   • immune system process   • lysosome localization   • cellular response to stimulus   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • positive regulation of cell motility   • regulation of cell migration   • myeloid leukocyte migration   • cell migration   • regulation of immune system process   • cell motility   • positive regulation of immune system process   • locomotion   • regulation of leukocyte migration   • positive regulation of neutrophil migration   • positive regulation of leukocyte migration   • neutrophil migration   • granulocyte migration   • leukocyte migration   • regulation of locomotion   • regulation of neutrophil migration   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • system process   • sensory perception   • nervous system process   • sensory perception of pain   • membrane   • cell periphery   • plasma membrane   • protein binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • response to peptide hormone   • mononuclear cell migration   • lymphocyte migration   • T cell migration   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cellular component organization or biogenesis   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • sperm principal piece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • Golgi apparatus   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VDM_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKITGI VETHFTFKD LHFKMFDVG GQRSERKKW IHCFEGVTA 
IIFCVALSD YDLVNRMHE SMKLFDSIC NNKWFTDTS IILFLNKKD 
LFEEKIKKS PLTICYPEY AGSNTYEEA AAYIQCQFE DLNKRKDTK 
EIYTHFTCA TDTKNVQFV FDAVTDVII KNNLKDCGL F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VDM_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VDM_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinSubstance-P
UniProtP20366
Sequence
>7VDM_Chain_L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB1
Sequence
>7VDM_Chain_R
IPVFLILFI ALVGLVGNG FVLWLLGFR MRRNAFSVY VLSLAGADF 
LFLCFQIIN CLVYLSNFF CSISINFPS FFTTVMTCA YLAGLSMLS 
TVSTERCLS VLWPIWYRC RRPRHLSAV VCVLLWALS LLLSILEGK 
FCGFLFSDG DSGWCQTFD FITAAWLIF LFMVLCGSS LALLVRILC 
GSRGLPLTR LYLTILLTV LVFLLCGLP FGIQWFLIL WIWKDSDVL 
FCHIHPVSV VLSSLNSSA NPIIYFFVG S


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7S8LAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ22.452021-11-17doi.org/10.1038/s41586-021-04126-6
7S8L (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.452021-11-17doi.org/10.1038/s41586-021-04126-6
7S8MAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ22.542021-11-17doi.org/10.1038/s41586-021-04126-6
7S8M (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.542021-11-17doi.org/10.1038/s41586-021-04126-6
7S8NAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ22.92021-11-17doi.org/10.1038/s41586-021-04126-6
7S8N (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.92021-11-17doi.org/10.1038/s41586-021-04126-6
7S8OAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-Gi1/β1/γ22.582021-11-17doi.org/10.1038/s41586-021-04126-6
7S8O (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.582021-11-17doi.org/10.1038/s41586-021-04126-6
7VDHAOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.92021-12-01doi.org/10.1038/s41586-021-04077-y
7VDH (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.92021-12-01doi.org/10.1038/s41586-021-04077-y
7VDLAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ23.222021-12-01doi.org/10.1038/s41586-021-04077-y
7VDL (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-3.222021-12-01doi.org/10.1038/s41586-021-04077-y
7VDMAOrphanOrphanMRGPRX2Homo sapiensSubstance-P-Gi1/β1/γ22.982021-12-01doi.org/10.1038/s41586-021-04077-y
7VDM (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensSubstance-P-2.982021-12-01doi.org/10.1038/s41586-021-04077-y
7VUYAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.842021-12-01doi.org/10.1038/s41586-021-04077-y
7VUY (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.842021-12-01doi.org/10.1038/s41586-021-04077-y
7VUZAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.892021-12-01doi.org/10.1038/s41586-021-04077-y
7VUZ (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.892021-12-01doi.org/10.1038/s41586-021-04077-y
7VV0AOrphanOrphanMRGPRX2Homo sapiensPAMP-12--3.52021-12-01doi.org/10.1038/s41586-021-04077-y
7VV3AOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.972021-12-01doi.org/10.1038/s41586-021-04077-y
7VV3 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.972021-12-01doi.org/10.1038/s41586-021-04077-y
7VV4AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14--2.972021-12-01doi.org/10.1038/s41586-021-04077-y
7VV5AOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.762021-12-01doi.org/10.1038/s41586-021-04077-y
7VV5 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.762021-12-01doi.org/10.1038/s41586-021-04077-y
7VV6AOrphanOrphanMRGPRX2Homo sapiensC48/80--3.32021-12-01doi.org/10.1038/s41586-021-04077-y




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