Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I37 6.2575406
2R:R:N48 6.9625459
3R:R:L55 5.5165138
4R:R:F64 4.7575467
5R:R:Y67 5.4625407
6R:R:F76 4.112557
7R:R:F78 5.564166
8R:R:L79 3.92507
9R:R:Y113 7.3125168
10R:R:M119 4.762556
11R:R:L120 6.6725459
12R:R:R127 6.7475469
13R:R:S130 5.01468
14R:R:V131 3.4375408
15R:R:W136 6.8466
16R:R:Y137 8.06667667
17R:R:R141 6.5568
18R:R:S146 4.575409
19R:R:L153 3.87457
20R:R:E164 6.0785174
21R:R:F170 4.395403
22R:R:W190 5.388507
23R:R:F195 7.015406
24R:R:R214 10.29254195
25R:R:L216 4.3975464
26R:R:L221 5.052568
27R:R:F232 7.0525409
28R:R:F239 6.696166
29R:R:W243 4.3685174
30R:R:F244 9.3685175
31R:R:N275 7.518559
32R:R:Y279 6.4025409
33R:R:F280 5.728336138
34A:A:V34 4.92585
35A:A:K46 4.665409
36A:A:M53 5.06754228
37A:A:F191 7.2175485
38A:A:L194 3.99684
39A:A:F196 8.78587
40A:A:K197 7.545416
41A:A:F199 8.65515
42A:A:Q204 5.54333619
43A:A:S206 5.375418
44A:A:W211 5.37167619
45A:A:I221 3.8654118
46A:A:F223 7.2285119
47A:A:V225 5.385407
48A:A:D229 7.0725498
49A:A:Y230 6.29333698
50A:A:F250 6.984297119
51A:A:W258 6.59167605
52A:A:F259 5.66254119
53A:A:I264 4.23754116
54A:A:L268 5.75754238
55A:A:C286 4.2375406
56A:A:Y287 4.4356147
57A:A:Y290 7.646147
58A:A:Y296 13.23754254
59A:A:T316 5.224243
60A:A:I319 6.554115
61A:A:Y320 9.0825197
62A:A:T321 6.825405
63A:A:F323 4.89754234
64A:A:C325 5.185407
65A:A:Q333 4.37485
66A:A:F336 5.215488
67A:A:I343 5.33407
68A:A:N347 6.0075468
69A:A:L348 4.205469
70A:A:L353 5.545467
71B:B:L14 3.135408
72B:B:L30 6.49405
73B:B:H54 6.965629
74B:B:K57 12.265419
75B:B:I58 4.715429
76B:B:Y59 8.2675418
77B:B:M61 4.13426
78B:B:W63 5.37714727
79B:B:L70 5.2275425
80B:B:Q75 7.8975419
81B:B:D76 5.614529
82B:B:L79 5.55477
83B:B:I80 6.896528
84B:B:I81 5.43577
85B:B:W82 10.78629
86B:B:D83 8.1975428
87B:B:S84 4.08425
88B:B:Y85 13.1975424
89B:B:N88 5.562527
90B:B:K89 7.03833629
91B:B:I93 6.93577
92B:B:L95 4.365478
93B:B:W99 7.075619
94B:B:Y105 5.01667676
95B:B:N110 6.1325414
96B:B:Y111 7.06514
97B:B:V112 4.838578
98B:B:C114 3.418578
99B:B:L117 5.186519
100B:B:N119 4.925419
101B:B:I123 4.10833616
102B:B:Y124 4.65143776
103B:B:L126 4.835475
104B:B:V133 6.15474
105B:B:H142 6.96857719
106B:B:Y145 5.15778918
107B:B:F151 5.162519
108B:B:Q156 5.605405
109B:B:I157 4.162517
110B:B:T159 4.896519
111B:B:S161 8.095419
112B:B:D163 7.896519
113B:B:C166 4.235448
114B:B:L168 4.614546
115B:B:W169 7.65714718
116B:B:F180 7.946547
117B:B:H183 7.81143749
118B:B:D186 4.13667619
119B:B:V187 5.256549
120B:B:L190 4.3675445
121B:B:F199 7.304549
122B:B:V200 6.8675436
123B:B:S201 4.875449
124B:B:D205 7.4075449
125B:B:S207 5.1375445
126B:B:K209 8.10333646
127B:B:L210 6.92405
128B:B:W211 8.87648
129B:B:Q220 8.685437
130B:B:F222 6.776538
131B:B:H225 9.81167639
132B:B:D228 6.92519
133B:B:I232 7.005438
134B:B:F234 3.51735
135B:B:F235 6.321676126
136B:B:F241 7.06429736
137B:B:T243 6.0625408
138B:B:D246 7.8475419
139B:B:D247 6.7539
140B:B:T249 5.365436
141B:B:R251 10.5867638
142B:B:L252 4.69754267
143B:B:F253 6.76333636
144B:B:D258 9.678537
145B:B:M262 6.99754264
146B:B:Y264 5.3725265
147B:B:F278 9.305407
148B:B:R283 8.59754159
149B:B:Y289 6.518577187
150B:B:D290 8.475406
151B:B:N295 7.79254186
152B:B:D298 8.10754159
153B:B:K301 6.864155
154B:B:H311 9.324109
155B:B:T329 5.37754108
156B:B:W332 12.47619
157B:B:D333 9.14754109
158B:B:L336 5.2875427
159B:B:K337 6.144106
160B:B:I338 4.32425
161B:B:W339 9.458336109
162G:G:R27 5.605408
163G:G:D36 5.65254125
164G:G:Y40 8.86254126
165G:G:L51 7.374156
166G:G:F61 5.07667628
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D75 R:R:S272 14.99111.78NoNo599
2R:R:L79 R:R:S272 14.33733YesNo079
3R:R:V123 R:R:Y279 46.25087.57NoYes099
4R:R:L120 R:R:Y279 44.57868.21YesYes099
5R:R:L120 R:R:N275 22.13728.24YesYes599
6R:R:D75 R:R:N275 20.491410.77NoYes599
7B:B:G288 B:B:V315 15.3063.68NoNo077
8B:B:G288 B:B:Y289 15.59132.9NoYes077
9B:B:D291 B:B:Y289 25.54593.45NoYes087
10B:B:C271 B:B:D291 26.61744.67NoNo058
11B:B:C271 B:B:D290 27.03876.22NoYes056
12B:B:D290 B:B:R314 28.103221.44YesNo068
13A:A:W258 B:B:R314 25.85194YesNo058
14A:A:N256 A:A:W258 36.14984.52NoYes085
15A:A:F259 A:A:N256 36.09884.83YesNo098
16A:A:F259 A:A:I221 36.09265.02YesYes1198
17A:A:I221 A:A:I253 25.21772.94YesNo088
18A:A:F223 A:A:I253 33.89045.02YesNo098
19A:A:F223 A:A:G40 1003.01YesNo099
20A:A:G40 A:A:K46 99.87483.49NoYes099
21A:A:K46 A:A:L38 97.56135.64YesNo098
22A:A:L38 A:A:M198 96.76554.24NoNo087
23A:A:F189 A:A:M198 96.36313.73NoNo097
24A:A:F189 A:A:F196 94.200216.08NoYes097
25A:A:F196 A:A:L194 93.21438.53YesYes874
26A:A:I343 A:A:L194 92.74452.85YesYes074
27A:A:I343 A:A:N347 92.0224.25YesYes078
28A:A:N347 R:R:S130 34.0724.47YesYes688
29A:A:C351 R:R:S130 28.21833.44NoYes648
30A:A:C351 R:R:R127 56.26354.18NoYes649
31R:R:R127 R:R:V123 46.02736.54YesNo699
32A:A:N347 R:R:Y137 57.658413.96YesYes687
33A:A:C351 R:R:Y137 28.47154.03NoYes647
34R:R:E126 R:R:Y137 26.86633.37NoYes697
35R:R:E126 R:R:Y67 26.87046.73NoYes097
36R:R:T122 R:R:Y67 25.69956.24NoYes077
37R:R:M119 R:R:T122 13.48983.01YesNo567
38R:R:L71 R:R:M119 12.16735.65NoYes596
39R:R:L71 R:R:N275 11.29168.24NoYes599
40R:R:F78 R:R:M109 10.05456.22YesNo064
41R:R:F78 R:R:Y113 10.71926.19YesYes1668
42R:R:L117 R:R:Y113 16.19077.03NoYes088
43R:R:F232 R:R:L117 17.88047.31YesNo098
44R:R:L153 R:R:W190 12.36492.28YesYes077
45B:B:D76 B:B:H54 14.43083.78YesYes299
46B:B:A56 B:B:D76 20.08833.09NoYes079
47B:B:A56 B:B:Q75 20.43283.03NoYes079
48B:B:Q75 B:B:W99 30.92933.29YesYes199
49B:B:L117 B:B:W99 25.30755.69YesYes199
50A:A:R208 A:A:W211 75.47786NoYes099
51A:A:L249 A:A:R208 75.34214.86NoNo099
52A:A:F223 A:A:L249 75.32427.31YesNo099
53A:A:K277 A:A:L232 18.80165.64NoNo998
54A:A:K277 A:A:Y230 19.78433.58NoYes998
55A:A:L266 A:A:T321 10.56877.37NoYes095
56A:A:C286 A:A:Y230 21.18545.38YesYes068
57A:A:F307 A:A:V225 10.24699.18NoYes087
58A:A:F250 A:A:F307 24.4516.43YesNo098
59A:A:F223 A:A:F250 35.025917.15YesYes1199
60A:A:C286 A:A:Y287 17.81795.38YesYes067
61A:A:M247 A:A:Y287 27.54125.99NoYes067
62A:A:F307 A:A:M247 14.02834.98NoNo086
63A:A:L310 A:A:M247 14.03457.07NoNo046
64A:A:F250 A:A:L310 15.03283.65YesNo094
65A:A:D229 A:A:S228 13.86587.36YesNo089
66A:A:D229 A:A:L232 15.83579.5YesNo988
67A:A:Q204 B:B:G144 14.97413.29YesNo198
68A:A:W211 B:B:Y145 58.11523.86YesYes198
69A:A:K210 B:B:Y145 44.73695.97NoYes198
70B:B:M188 B:B:Y145 16.26993.59NoYes088
71A:A:K210 B:B:D246 44.21975.53NoYes199
72B:B:R314 B:B:W332 21.687323.99NoYes089
73A:A:F250 A:A:I264 10.8523.77YesYes1196
74B:B:L7 G:G:V16 11.30194.47NoNo087
75B:B:A11 G:G:V16 12.32731.7NoNo057
76B:B:A11 G:G:L19 14.37711.58NoNo059
77B:B:L14 G:G:L19 16.42554.15YesNo089
78B:B:L14 G:G:A23 28.68681.58YesNo088
79B:B:I18 G:G:A23 29.70643.25NoNo078
80B:B:I18 B:B:R22 15.36293.76NoNo076
81B:B:D258 B:B:R22 15.86968.34YesNo076
82B:B:D258 B:B:F222 32.45664.78YesYes378
83B:B:F222 B:B:F253 34.7469.65YesYes386
84B:B:F253 B:B:R251 38.81148.55YesYes368
85B:B:H225 B:B:R251 13.408924.83YesYes398
86B:B:D247 B:B:H225 17.40373.78YesYes399
87B:B:D247 B:B:S227 45.23845.89YesNo096
88B:B:D246 B:B:S227 45.37174.42YesNo096
89B:B:I18 G:G:E22 15.36294.1NoNo079
90B:B:D258 G:G:E22 15.86963.9YesNo079
91B:B:E226 B:B:R251 13.390810.47NoYes038
92B:B:D247 B:B:E226 13.55917.8YesNo093
93B:B:R251 B:B:T249 13.43353.88YesYes386
94B:B:D247 B:B:T249 13.93738.67YesYes396
95B:B:L14 B:B:Q17 10.27623.99YesNo084
96B:B:C250 B:B:Y264 11.3934.03NoYes085
97B:B:C250 B:B:I273 11.6226.55NoNo086
98B:B:I273 B:B:Y289 14.07468.46NoYes067
99B:B:C294 B:B:V315 12.07825.12NoNo057
100B:B:N340 G:G:F61 10.73113.62NoYes098
101B:B:S84 G:G:F61 15.245.28YesYes258
102B:B:M61 B:B:W63 19.04265.82YesYes267
103B:B:C317 B:B:M61 28.31293.24NoYes076
104B:B:C317 B:B:S316 28.64863.44NoNo079
105B:B:S316 B:B:W332 28.99077.41NoYes099
106B:B:I338 G:G:F61 10.05043.77YesYes258
107B:B:L190 B:B:S160 11.78163YesNo056
108B:B:S147 B:B:S160 16.55214.89NoNo096
109B:B:M188 B:B:S147 16.75814.6NoNo089
110B:B:I157 B:B:W169 18.42543.52YesYes178
111B:B:H142 B:B:W169 30.1223.17YesYes198
112B:B:H142 B:B:S161 19.848415.34YesYes199
113B:B:G162 B:B:S161 21.57043.71NoYes199
114B:B:G162 B:B:Y145 21.75335.79NoYes198
115B:B:D163 B:B:H142 13.893212.61YesYes199
116B:B:D163 B:B:G144 14.7355.03YesNo198
117B:B:I123 B:B:Y111 12.31293.63YesYes164
118R:R:F232 R:R:L120 22.33556.09YesYes099
119R:R:L153 R:R:T122 12.01142.95YesNo577
120A:A:I221 A:A:I264 11.43392.94YesYes1186
121B:B:L117 B:B:Y145 11.59273.52YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7VUY
Class A
SubFamily Orphan
Type A orphans
SubType MRGPRX2
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.84
Date 2021-12-01
D.O.I. 10.1038/s41586-021-04077-y
Net Summary
Imin 2.9
Number of Linked Nodes 817
Number of Links 1015
Number of Hubs 166
Number of Links mediated by Hubs 606
Number of Communities 27
Number of Nodes involved in Communities 252
Number of Links involved in Communities 370
Path Summary
Number Of Nodes in MetaPath 122
Number Of Links MetaPath 121
Number of Shortest Paths 1170030
Length Of Smallest Path 3
Average Path Length 25.6165
Length of Longest Path 59
Minimum Path Strength 1.235
Average Path Strength 6.10665
Maximum Path Strength 25.34
Minimum Path Correlation 0.7
Average Path Correlation 0.981598
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 48.0493
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.5994
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ96LB1
Sequence
>7VUY_Chain_R
VFLILFIAL VGLVGNGFV LWLLGFRMR RNAFSVYVL SLAGADFLF 
LCFQIINCL VYLSNFFCS ISINFPSFF TTVMTCAYL AGLSMLSTV 
STERCLSVL WPIWYRCRR PRHLSAVVC VLLWALSLL LSILEGKFC 
GFLFSDGDS GWCQTFDFI TAAWLIFLF MVLCGSSLA LLVRILCGS 
RGLPLTRLY LTILLTVLV FLLCGLPFG IQWFLILWI WKDSDVLFC 
HIHPVSVVL SSLNSSANP IIYFFVGS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VUY_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKTGI VETHFTFKD LHFKMFDVG GQRSERKKW IHCFEGVTA 
IIFCVALSD YDLVLMNRM HESMKLFDS ICNNKWFTD TSIILFLNK 
KDLFEEKIK KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD 
TKEIYTHFT CATDTKNVQ FVFDAVTDV IIKNNLKDC GL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VUY_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VUY_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7S8LAOrphanA orphansMRGPRX2Homo sapiensCortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;22.452021-11-1710.1038/s41586-021-04126-6
7S8MAOrphanA orphansMRGPRX2Homo sapiensCortistatin-14-Gi1/&β;1/&γ;22.542021-11-1710.1038/s41586-021-04126-6
7S8NAOrphanA orphansMRGPRX2Homo sapiens(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;22.92021-11-1710.1038/s41586-021-04126-6
7S8OAOrphanA orphansMRGPRX2Homo sapiens(R)-Zinc-3573-Gi1/&β;1/&γ;22.582021-11-1710.1038/s41586-021-04126-6
7VDHAOrphanA orphansMRGPRX2Homo sapiensC48/80-Gi1/&β;1/&γ;22.92021-12-0110.1038/s41586-021-04077-y
7VDLAOrphanA orphansMRGPRX2Homo sapiensCortistatin-14-Gi1/&β;1/&γ;23.222021-12-0110.1038/s41586-021-04077-y
7VDMAOrphanA orphansMRGPRX2Homo sapiensSubstance P-Gi1/&β;1/&γ;22.982021-12-0110.1038/s41586-021-04077-y
7VUYAOrphanA orphansMRGPRX2Homo sapiens--Gi1/&β;1/&γ;22.842021-12-0110.1038/s41586-021-04077-y
7VUZAOrphanA orphansMRGPRX2Homo sapiens--Gi1/&β;1/&γ;22.892021-12-0110.1038/s41586-021-04077-y
7VV0AOrphanA orphansMRGPRX2Homo sapiensPAMP-12--3.52021-12-0110.1038/s41586-021-04077-y
7VV3AOrphanA orphansMRGPRX2Homo sapiens--Gi1/&β;1/&γ;22.972021-12-0110.1038/s41586-021-04077-y
7VV4AOrphanA orphansMRGPRX2Homo sapiensCortistatin-14--2.972021-12-0110.1038/s41586-021-04077-y
7VV5AOrphanA orphansMRGPRX2Homo sapiensC48/80-Gi1/&β;1/&γ;22.762021-12-0110.1038/s41586-021-04077-y
7VV6AOrphanA orphansMRGPRX2Homo sapiensC48/80--3.32021-12-0110.1038/s41586-021-04077-y




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VUY.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.