Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 4.1875449
2A:A:L23 3.54446
3A:A:E25 6.47254144
4A:A:V34 5.238515
5A:A:L36 4.045417
6A:A:L37 6.305409
7A:A:L38 5.57254158
8A:A:L39 5.485409
9A:A:K46 4.784159
10A:A:Q52 6.11254169
11A:A:F191 10.3575415
12A:A:L194 5.042514
13A:A:F196 9.238517
14A:A:K197 5.802566
15A:A:M198 4.538507
16A:A:F199 9.878565
17A:A:Q204 6.1075469
18A:A:K210 5.905469
19A:A:W211 5.268569
20A:A:H213 5.625478
21A:A:I221 5.1425478
22A:A:F223 7.6725409
23A:A:C224 2.99507
24A:A:V225 4.606537
25A:A:L227 5.2225437
26A:A:S228 3.78409
27A:A:D229 4.78438
28A:A:Y230 9.424538
29A:A:L232 6.2025438
30A:A:F250 5.98333679
31A:A:C254 4.676575
32A:A:W258 7.36833675
33A:A:F259 6.9075479
34A:A:I264 3.95476
35A:A:L266 5.2525439
36A:A:L268 5.416538
37A:A:K277 6.38439
38A:A:I278 4.16536
39A:A:L283 4.474537
40A:A:C286 4.7525436
41A:A:Y287 6.2275837
42A:A:Y290 5.57333637
43A:A:E298 3.845434
44A:A:Y320 7.6045127
45A:A:T321 7.9435
46A:A:N331 7.9154168
47A:A:Q333 6.3225415
48A:A:F336 4.962518
49A:A:I343 5.3725417
50A:A:C351 3.96414
51A:A:L353 8.0625407
52A:A:F354 7.065407
53B:B:L7 2.555408
54B:B:V40 3.7985133
55B:B:M45 4.2575404
56B:B:L51 8.165409
57B:B:H54 10.5175449
58B:B:Y59 8.372578
59B:B:M61 3.588546
60B:B:W63 6.46667647
61B:B:L70 4.8725445
62B:B:V71 4.27754118
63B:B:D76 6.43409
64B:B:L79 4.4654117
65B:B:I80 7.528548
66B:B:I81 4.3285117
67B:B:W82 11.144549
68B:B:D83 7.47448
69B:B:N88 5.542547
70B:B:K89 6.60143749
71B:B:I93 5.57507
72B:B:L95 5.0554118
73B:B:W99 8.21667669
74B:B:Y105 4.632867116
75B:B:N110 7.5875484
76B:B:Y111 6.44584
77B:B:V112 4.1985118
78B:B:C114 3.84254118
79B:B:L117 4.5125469
80B:B:N119 4.5375469
81B:B:I120 4.04754116
82B:B:I123 4.284586
83B:B:Y124 4.5756116
84B:B:H142 8.14689
85B:B:Y145 5.73556968
86B:B:C148 5.0825496
87B:B:C149 4.7375488
88B:B:F151 3.705609
89B:B:L152 3.805403
90B:B:I157 4.01487
91B:B:T159 6.032589
92B:B:S160 4.42496
93B:B:D163 7.902589
94B:B:C166 3.81498
95B:B:L168 4.646596
96B:B:W169 9.61833688
97B:B:F180 8.618597
98B:B:H183 8.59333699
99B:B:D186 4.702569
100B:B:V187 4.99499
101B:B:L190 5.138595
102B:B:F199 9.435499
103B:B:V200 7.5254106
104B:B:C204 5.5075467
105B:B:D205 6.7325499
106B:B:K209 9.464596
107B:B:L210 5.52405
108B:B:W211 10.58598
109B:B:Q220 7.38754107
110B:B:F222 7.4185108
111B:B:H225 9.653336109
112B:B:I232 6.61754108
113B:B:F234 5.5945105
114B:B:F235 6.05333626
115B:B:P236 5.6675427
116B:B:F241 7.916106
117B:B:D247 8.8625109
118B:B:T249 7.44106
119B:B:R251 11.42836108
120B:B:F253 8.4285106
121B:B:R256 8.8875409
122B:B:D258 10.984107
123B:B:Y264 4.75333625
124B:B:I269 4.56424
125B:B:R283 7.98754139
126B:B:L285 4.42167626
127B:B:Y289 5.98875827
128B:B:D290 9.015406
129B:B:C294 4.408525
130B:B:N295 8.5975426
131B:B:W297 4.09428
132B:B:L300 3.7954196
133B:B:K301 5.755405
134B:B:R304 8.37425
135B:B:H311 8.86529
136B:B:L318 3.025426
137B:B:M325 5.515405
138B:B:V327 3.41406
139B:B:T329 6.5225428
140B:B:W332 13.0186779
141B:B:D333 8.0425429
142B:B:K337 6.38426
143B:B:W339 10.148529
144B:B:N340 4.622509
145G:G:I9 3.175402
146G:G:V16 2.2625407
147G:G:R27 6.66408
148G:G:Y40 10.43426
149G:G:D48 5.75667609
150G:G:L51 6.01254136
151G:G:N59 4.045409
152G:G:F61 5.10667648
153R:R:I37 3.616556
154R:R:L54 5.3675458
155R:R:F64 4.8417
156R:R:Y67 8.418517
157R:R:F76 4.544237
158R:R:F78 6.185656
159R:R:L79 5.4925457
160R:R:Q82 5.4675455
161R:R:M109 4.7525454
162R:R:Y113 6.59833658
163R:R:M119 5.525416
164R:R:L120 6.714519
165R:R:T122 4.92417
166R:R:R127 6.992519
167R:R:S130 4.32418
168R:R:V131 4.195418
169R:R:W136 4.3475416
170R:R:Y137 6.43833617
171R:R:R141 5.69857718
172R:R:V149 4.5725416
173R:R:L153 5.1625417
174R:R:W154 5.3875409
175R:R:F183 4.655264
176R:R:F195 6.9775406
177R:R:I209 3.846516
178R:R:R214 8.2254125
179R:R:L216 3.37414
180R:R:I225 4.7407
181R:R:F232 6.71409
182R:R:F239 6.38656
183R:R:Q242 5.724501
184R:R:W250 4.655401
185R:R:H261 5.845402
186R:R:N271 5.815419
187R:R:N275 8.745419
188R:R:I278 4.44418
189R:R:Y279 5.30833619
190R:R:F280 5.89167658
191R:R:F281 4.09833656
192R:R:F285 3.884556
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:S316 B:B:W332 27.15044.94NoYes099
2A:A:W258 B:B:W332 24.78913.75YesYes759
3A:A:N256 A:A:W258 80.12164.52NoYes785
4A:A:F259 A:A:N256 80.17496.04YesNo798
5A:A:F259 A:A:I221 80.55628.79YesYes798
6A:A:I221 A:A:L39 39.42554.28YesYes089
7A:A:F223 A:A:L39 47.5563.65YesYes099
8A:A:F223 A:A:L266 62.48853.65YesYes099
9A:A:L266 A:A:V225 58.40872.98YesYes397
10A:A:S246 A:A:V225 99.56454.85NoYes097
11A:A:A41 A:A:S246 99.49551.71NoNo079
12A:A:A41 A:A:S44 99.31091.71NoNo079
13A:A:C224 A:A:S44 99.25031.72YesNo079
14A:A:I221 A:A:I264 42.16612.94YesYes786
15A:A:F250 A:A:I264 42.08593.77YesYes796
16A:A:F250 A:A:F307 44.55833.22YesNo098
17A:A:F307 A:A:V225 39.09039.18NoYes087
18A:A:C224 A:A:I49 96.73233.27YesNo077
19A:A:I49 A:A:M53 99.3245.83NoNo078
20A:A:F189 A:A:M53 94.53629.95NoNo098
21A:A:F189 A:A:F196 95.356217.15NoYes097
22A:A:F196 A:A:L194 96.40548.53YesYes174
23B:B:C149 B:B:T159 10.74093.38YesYes889
24B:B:H142 B:B:T159 11.62636.85YesYes899
25A:A:N347 R:R:Y137 55.64729.3NoYes187
26A:A:I343 A:A:N347 99.69434.25YesNo178
27A:A:I343 A:A:L194 1004.28YesYes174
28A:A:W211 B:B:Y145 15.42513.86YesYes698
29A:A:R208 A:A:W211 16.53255NoYes099
30A:A:L249 A:A:R208 16.29474.86NoNo099
31A:A:F223 A:A:L249 16.39557.31YesNo099
32A:A:N347 R:R:S130 43.94742.98NoYes188
33A:A:C351 R:R:S130 39.13593.44YesYes148
34A:A:C351 R:R:R127 67.75054.18YesYes149
35A:A:C351 R:R:Y137 39.52584.03YesYes147
36A:A:C351 R:R:F64 10.55424.19YesYes147
37B:B:N340 G:G:F61 11.86643.62YesYes098
38B:B:L308 B:B:M45 11.94377.07NoYes074
39B:B:C294 B:B:L308 12.19154.76YesNo057
40B:B:C294 B:B:G288 17.65573.92YesNo257
41B:B:G288 B:B:Y289 21.15262.9NoYes277
42B:B:I273 B:B:Y289 30.06529.67NoYes267
43B:B:G244 B:B:I273 29.76465.29NoNo056
44B:B:G244 B:B:T243 29.44873.64NoNo058
45B:B:I232 B:B:T243 23.8759.12YesNo088
46B:B:F241 B:B:I232 16.91865.02YesYes1068
47B:B:F222 B:B:F241 13.314710.72YesYes1086
48B:B:D258 B:B:F222 12.48194.78YesYes1078
49B:B:D258 B:B:R22 11.23115.48YesNo076
50B:B:W297 B:B:Y289 18.77964.82YesYes287
51B:B:W297 B:B:Y264 18.19912.89YesYes285
52B:B:L285 B:B:Y264 11.85524.69YesYes265
53B:B:C317 B:B:M61 16.70383.24NoYes076
54B:B:S84 G:G:F61 10.05515.28NoYes458
55B:B:H142 B:B:S161 16.816816.74YesNo899
56B:B:G162 B:B:Y145 18.17238.69NoYes098
57B:B:G162 B:B:S161 17.8993.71NoNo099
58B:B:D290 B:B:R314 62.765123.82YesNo068
59B:B:C271 B:B:D290 61.91783.11NoYes056
60R:R:R127 R:R:Y279 67.37984.12YesYes199
61R:R:L120 R:R:Y279 62.20798.21YesYes199
62R:R:F232 R:R:L120 60.02856.09YesYes099
63R:R:F232 R:R:L117 56.55766.09YesNo098
64R:R:L117 R:R:Y113 56.177.03NoYes088
65R:R:F78 R:R:Y113 20.43937.22YesYes568
66R:R:F239 R:R:Y113 22.716212.38YesYes568
67R:R:F64 R:R:V68 10.48023.93YesNo078
68R:R:L55 R:R:V68 10.04752.98NoNo088
69R:R:F81 R:R:M109 13.61616.22NoYes054
70R:R:F81 R:R:I84 11.91876.28NoNo055
71R:R:F105 R:R:I84 11.06952.51NoNo055
72R:R:L114 R:R:Y113 13.48113.52NoYes068
73R:R:L114 R:R:S161 12.62093NoNo067
74R:R:C111 R:R:S161 11.75953.44NoNo057
75R:R:C111 R:R:L158 11.32824.76NoNo054
76R:R:I162 R:R:L158 10.89672.85NoNo044
77R:R:I162 R:R:T107 10.46483.04NoNo044
78R:R:L171 R:R:T107 10.03265.9NoNo014
79B:B:C271 B:B:Y289 60.48414.03NoYes257
80B:B:C317 B:B:S316 17.15663.44NoNo079
81A:A:W258 B:B:R314 56.18296YesNo758
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7VUY
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRX2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.84
Date 2021-12-01
D.O.I. 10.1038/s41586-021-04077-y
Net Summary
Imin 2.8
Number of Linked Nodes 840
Number of Links 1077
Number of Hubs 192
Number of Links mediated by Hubs 682
Number of Communities 27
Number of Nodes involved in Communities 301
Number of Links involved in Communities 441
Path Summary
Number Of Nodes in MetaPath 82
Number Of Links MetaPath 81
Number of Shortest Paths 1045034
Length Of Smallest Path 3
Average Path Length 27.9475
Length of Longest Path 66
Minimum Path Strength 1.345
Average Path Strength 5.91271
Maximum Path Strength 27.34
Minimum Path Correlation 0.7
Average Path Correlation 0.977697
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 43.8
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.7981
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • sleep   • regulation of cytokinesis   • regulation of biological process   • regulation of cellular process   • positive regulation of cell division   • regulation of cell cycle process   • biological regulation   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cellular process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • establishment of organelle localization   • regulated exocytosis   • cellular localization   • response to stimulus   • transport   • cell activation involved in immune response   • leukocyte degranulation   • myeloid leukocyte activation   • myeloid leukocyte mediated immunity   • vesicle-mediated transport   • leukocyte activation   • localization   • secretion by cell   • organelle localization   • leukocyte activation involved in immune response   • establishment of localization in cell   • mast cell activation   • leukocyte mediated immunity   • mast cell mediated immunity   • immune response   • secretion   • cell activation   • vacuolar localization   • export from cell   • mast cell degranulation   • establishment of localization   • myeloid cell activation involved in immune response   • immune effector process   • mast cell activation involved in immune response   • exocytosis   • immune system process   • lysosome localization   • cellular response to stimulus   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • system process   • sensory perception   • nervous system process   • sensory perception of pain   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cellular component organization or biogenesis   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VUY_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKTGI VETHFTFKD LHFKMFDVG GQRSERKKW IHCFEGVTA 
IIFCVALSD YDLVLMNRM HESMKLFDS ICNNKWFTD TSIILFLNK 
KDLFEEKIK KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD 
TKEIYTHFT CATDTKNVQ FVFDAVTDV IIKNNLKDC GLFCIAEDE 
E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VUY_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VUY_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB1
Sequence
>7VUY_Chain_R
TLIPVFLIL FIALVGLVG NGFVLWLLG FRMRRNAFS VYVLSLAGA 
DFLFLCFQI INCLVYLSN FFCSISINF PSFFTTVMT CAYLAGLSM 
LSTVSTERC LSVLWPIWY RCRRPRHLS AVVCVLLWA LSLLLSILE 
GKFCGFLFS DGDSGWCQT FDFITAAWL IFLFMVLCG SSLALLVRI 
LCGSRGLPL TRLYLTILL TVLVFLLCG LPFGIQWFL ILWIWKDSD 
VLFCHIHPV SVVLSSLNS SANPIIYFF VGSFRK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VV6AOrphanOrphanMRGPRX2Homo sapiensC48/80--3.32021-12-0110.1038/s41586-021-04077-y
7VV4AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14--2.972021-12-0110.1038/s41586-021-04077-y
7VV0AOrphanOrphanMRGPRX2Homo sapiensPAMP-12--3.52021-12-0110.1038/s41586-021-04077-y
7VV5AOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.762021-12-0110.1038/s41586-021-04077-y
7VV5 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.762021-12-0110.1038/s41586-021-04077-y
7VV3AOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.972021-12-0110.1038/s41586-021-04077-y
7VV3 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.972021-12-0110.1038/s41586-021-04077-y
7VUZAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.892021-12-0110.1038/s41586-021-04077-y
7VUZ (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.892021-12-0110.1038/s41586-021-04077-y
7VUYAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.842021-12-0110.1038/s41586-021-04077-y
7VUY (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.842021-12-0110.1038/s41586-021-04077-y
7VDMAOrphanOrphanMRGPRX2Homo sapiensSubstance-P-Gi1/β1/γ22.982021-12-0110.1038/s41586-021-04077-y
7VDM (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensSubstance-P-2.982021-12-0110.1038/s41586-021-04077-y
7VDLAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ23.222021-12-0110.1038/s41586-021-04077-y
7VDL (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-3.222021-12-0110.1038/s41586-021-04077-y
7VDHAOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.92021-12-0110.1038/s41586-021-04077-y
7VDH (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.92021-12-0110.1038/s41586-021-04077-y
7S8NAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ22.92021-11-1710.1038/s41586-021-04126-6
7S8N (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.92021-11-1710.1038/s41586-021-04126-6
7S8LAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ22.452021-11-1710.1038/s41586-021-04126-6
7S8L (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.452021-11-1710.1038/s41586-021-04126-6
7S8OAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-Gi1/β1/γ22.582021-11-1710.1038/s41586-021-04126-6
7S8O (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.582021-11-1710.1038/s41586-021-04126-6
7S8MAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ22.542021-11-1710.1038/s41586-021-04126-6
7S8M (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.542021-11-1710.1038/s41586-021-04126-6




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