psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E164	2.5	Yes	No	3	0	4
2	L:L:?1	R:R:C180	3	Yes	Yes	3	0	9
3	L:L:?1	R:R:D184	10.25	Yes	Yes	3	0	3
4	L:L:?1	R:R:W243	6.45	Yes	Yes	0	0	4
5	L:L:?1	R:R:L247	6.54	Yes	No	0	0	3
6	L:L:?1	R:R:W248	48.4	Yes	Yes	3	0	3
7	R:R:P33	R:R:T30	6.99	No	No	5	4	3
8	R:R:T30	R:R:Y89	2.5	No	Yes	0	3	2
9	R:R:P262	R:R:T30	3.5	No	No	5	1	3
10	R:R:I32	R:R:P33	5.08	No	No	0	5	4
11	R:R:I32	R:R:L36	2.85	No	No	0	5	5
12	R:R:P262	R:R:P33	3.9	No	No	5	1	4
13	R:R:C86	R:R:V34	3.42	No	No	0	5	4
14	R:R:V34	R:R:Y89	2.52	No	Yes	0	4	2
15	R:R:I37	R:R:V265	3.07	No	Yes	0	6	4
16	R:R:I37	R:R:V266	3.07	No	No	0	6	5
17	R:R:F39	R:R:L38	2.44	No	No	0	5	5
18	R:R:C86	R:R:L38	4.76	No	No	0	5	5
19	R:R:I40	R:R:S269	3.1	No	No	0	7	5
20	R:R:A41	R:R:I83	3.25	No	No	0	5	6
21	R:R:G44	R:R:V43	3.68	No	No	0	9	5
22	R:R:G44	R:R:S273	3.71	No	No	0	9	8
23	R:R:F76	R:R:L45	7.31	No	Yes	2	7	7
24	R:R:L45	R:R:L79	4.15	Yes	Yes	2	7	7
25	R:R:C80	R:R:L45	3.17	No	Yes	2	4	7
26	R:R:I83	R:R:L45	2.85	No	Yes	0	6	7
27	R:R:G47	R:R:V46	3.68	No	No	0	8	5
28	R:R:F50	R:R:V46	7.87	No	No	0	5	5
29	R:R:D75	R:R:N48	12.12	No	No	0	9	9
30	R:R:N48	R:R:P276	8.15	No	No	0	9	9
31	R:R:F280	R:R:V51	3.93	Yes	Yes	4	8	9
32	R:R:F281	R:R:V51	2.62	No	Yes	4	6	9
33	R:R:F57	R:R:W53	6.01	No	No	0	5	6
34	R:R:L54	R:R:R58	14.58	No	No	0	8	5
35	R:R:L55	R:R:S65	3	Yes	No	0	8	8
36	R:R:L55	R:R:V68	2.98	Yes	No	4	8	8
37	R:R:L55	R:R:L69	8.3	Yes	No	0	8	7
38	R:R:F280	R:R:L55	9.74	Yes	Yes	4	8	8
39	R:R:R61	R:R:S65	2.64	No	No	0	7	8
40	R:R:N62	R:R:S65	4.47	No	No	0	8	8
41	R:R:A63	R:R:R141	4.15	No	Yes	0	7	8
42	R:R:F64	R:R:Y67	3.09	No	Yes	1	7	7
43	R:R:F64	R:R:V123	6.55	No	No	1	7	9
44	R:R:S146	R:R:V66	4.85	No	No	0	9	6
45	R:R:T122	R:R:Y67	4.99	No	Yes	0	7	7
46	R:R:V123	R:R:Y67	2.52	No	Yes	1	9	7
47	R:R:E126	R:R:Y67	6.73	No	Yes	1	9	7
48	R:R:S146	R:R:Y67	7.63	No	Yes	0	9	7
49	R:R:C150	R:R:Y67	2.69	No	Yes	1	7	7
50	R:R:F280	R:R:V68	2.62	Yes	No	4	8	8
51	R:R:M119	R:R:S70	6.13	No	No	1	6	9
52	R:R:C150	R:R:S70	5.16	No	No	1	7	9
53	R:R:S70	R:R:W154	2.47	No	No	0	9	9
54	R:R:L120	R:R:L71	4.15	No	No	6	9	9
55	R:R:L71	R:R:N275	4.12	No	Yes	6	9	9
56	R:R:A74	R:R:W154	3.89	No	No	0	9	9
57	R:R:D75	R:R:L79	2.71	No	Yes	2	9	7
58	R:R:D75	R:R:S272	10.31	No	No	2	9	9
59	R:R:C80	R:R:F76	6.98	No	No	2	4	7
60	R:R:F78	R:R:Q82	9.37	Yes	No	2	6	5
61	R:R:F78	R:R:M109	4.98	Yes	Yes	2	6	4
62	R:R:F78	R:R:Y113	3.09	Yes	Yes	0	6	8
63	R:R:F78	R:R:S272	2.64	Yes	No	2	6	9
64	R:R:L79	R:R:S272	7.51	Yes	No	2	7	9
65	R:R:F105	R:R:F81	11.79	Yes	No	0	5	5
66	R:R:F81	R:R:V108	7.87	No	No	0	5	6
67	R:R:F81	R:R:M109	2.49	No	Yes	0	5	4
68	R:R:M109	R:R:Q82	4.08	Yes	No	2	4	5
69	R:R:Q82	R:R:V265	4.3	No	Yes	0	5	4
70	R:R:I83	R:R:L87	2.85	No	No	0	6	4
71	R:R:F101	R:R:I84	11.3	Yes	No	0	4	5
72	R:R:F101	R:R:N85	7.25	Yes	No	7	4	4
73	R:R:F105	R:R:N85	13.29	Yes	No	7	5	4
74	R:R:L90	R:R:Y89	3.52	No	Yes	0	4	2
75	R:R:N92	R:R:S98	8.94	No	No	0	3	6
76	R:R:F93	R:R:F94	11.79	No	No	0	1	3
77	R:R:F101	R:R:P102	10.11	Yes	No	0	4	5
78	R:R:F101	R:R:F105	23.58	Yes	Yes	7	4	5
79	R:R:F104	R:R:V108	3.93	No	No	0	4	6
80	R:R:F104	R:R:L171	2.44	No	No	0	4	1
81	R:R:F105	R:R:T106	10.38	Yes	No	0	5	5
82	R:R:F170	R:R:T106	3.89	No	No	0	3	5
83	R:R:S161	R:R:T107	3.2	No	No	0	7	4
84	R:R:F170	R:R:T107	3.89	No	No	0	3	4
85	R:R:F239	R:R:M109	2.49	Yes	Yes	0	6	4
86	R:R:C111	R:R:S157	5.16	No	No	0	5	8
87	R:R:C111	R:R:L158	3.17	No	No	0	5	4
88	R:R:C111	R:R:S161	5.16	No	No	0	5	7
89	R:R:L117	R:R:Y113	3.52	No	Yes	0	8	8
90	R:R:F239	R:R:Y113	6.19	Yes	Yes	0	6	8
91	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
92	R:R:L114	R:R:S157	6.01	No	No	0	6	8
93	R:R:A115	R:R:W154	7.78	No	No	0	7	9
94	R:R:A115	R:R:S157	3.42	No	No	0	7	8
95	R:R:F232	R:R:L117	2.44	Yes	No	0	9	8
96	R:R:L153	R:R:S118	9.01	No	No	0	7	8
97	R:R:C150	R:R:M119	4.86	No	No	1	7	6
98	R:R:L153	R:R:M119	4.24	No	No	0	7	6
99	R:R:F232	R:R:L120	4.87	Yes	No	0	9	9
100	R:R:L120	R:R:N275	2.75	No	Yes	6	9	9
101	R:R:L194	R:R:S121	4.5	No	No	0	8	7
102	R:R:L198	R:R:S121	3	No	No	0	8	7
103	R:R:R127	R:R:V123	6.54	No	No	0	9	9
104	R:R:S124	R:R:S201	4.89	No	No	0	9	8
105	R:R:S201	R:R:T125	3.2	No	No	0	8	7
106	R:R:E126	R:R:Y137	5.61	No	No	1	9	7
107	R:R:E126	R:R:R141	5.82	No	Yes	1	9	8
108	R:R:C128	R:R:L132	3.17	No	No	0	8	6
109	R:R:S130	R:R:Y137	7.63	No	No	0	8	7
110	R:R:L205	R:R:V131	4.47	No	No	0	8	8
111	R:R:R208	R:R:V131	2.62	No	No	0	7	8
112	R:R:L132	R:R:W133	3.42	No	No	0	6	5
113	R:R:R140	R:R:W136	4	No	No	0	6	6
114	R:R:R141	R:R:W136	3	Yes	No	0	8	6
115	R:R:R141	R:R:Y137	8.23	Yes	No	1	8	7
116	R:R:C139	R:R:R138	2.79	No	No	0	7	7
117	R:R:P142	R:R:R141	2.88	No	Yes	0	7	8
118	R:R:L145	R:R:R141	4.86	No	Yes	0	5	8
119	R:R:H144	R:R:R143	16.93	No	No	0	5	5
120	R:R:L153	R:R:V149	2.98	No	No	0	7	6
121	R:R:L156	R:R:W190	3.42	No	No	0	6	7
122	R:R:I162	R:R:L158	4.28	No	No	0	4	4
123	R:R:L159	R:R:L163	2.77	No	No	0	4	8
124	R:R:L160	R:R:T187	7.37	No	No	0	4	4
125	R:R:I162	R:R:K166	2.91	No	No	0	4	3
126	R:R:F183	R:R:L163	8.53	No	No	0	4	8
127	R:R:D184	R:R:E164	6.5	Yes	No	3	3	4
128	R:R:E164	R:R:F244	8.16	No	Yes	3	4	5
129	R:R:F170	R:R:G165	3.01	No	No	0	3	3
130	R:R:K166	R:R:L171	7.05	No	No	0	3	1
131	R:R:F167	R:R:W179	11.02	No	No	0	4	2
132	R:R:C168	R:R:C180	7.28	No	Yes	0	6	9
133	R:R:D176	R:R:W179	4.47	No	No	0	3	2
134	R:R:G178	R:R:S177	3.71	No	No	0	3	3
135	R:R:C180	R:R:D184	4.67	Yes	Yes	3	9	3
136	R:R:C180	R:R:W248	2.61	Yes	Yes	3	9	3
137	R:R:Q181	R:R:W248	17.52	No	Yes	0	3	3
138	R:R:D184	R:R:F244	5.97	Yes	Yes	3	3	5
139	R:R:D184	R:R:W248	7.82	Yes	Yes	3	3	3
140	R:R:F185	R:R:L245	2.44	No	No	0	3	5
141	R:R:F244	R:R:T187	9.08	Yes	No	0	5	4
142	R:R:F193	R:R:W190	4.01	No	No	0	5	7
143	R:R:I192	R:R:M196	2.92	No	No	0	5	5
144	R:R:F193	R:R:M196	2.49	No	No	0	5	5
145	R:R:F193	R:R:V197	5.24	No	No	0	5	6
146	R:R:C199	R:R:F195	6.98	No	No	0	5	6
147	R:R:F195	R:R:F232	5.36	No	Yes	0	6	9
148	R:R:F195	R:R:L233	8.53	No	No	0	6	7
149	R:R:L198	R:R:V229	4.47	No	No	0	8	8
150	R:R:F232	R:R:L198	3.65	Yes	No	0	9	8
151	R:R:I225	R:R:S202	3.1	No	No	0	7	8
152	R:R:S202	R:R:V229	3.23	No	No	0	8	8
153	R:R:I209	R:R:L205	4.28	Yes	No	0	6	8
154	R:R:L206	R:R:Y222	8.21	No	Yes	0	5	6
155	R:R:I225	R:R:L206	5.71	No	No	0	7	5
156	R:R:I209	R:R:S213	4.64	Yes	No	0	6	7
157	R:R:L210	R:R:Y222	9.38	No	Yes	0	5	6
158	R:R:L216	R:R:S213	3	No	No	0	4	7
159	R:R:I278	R:R:L227	4.28	No	No	0	8	7
160	R:R:T228	R:R:Y279	3.75	No	No	0	7	9
161	R:R:N271	R:R:V231	2.96	Yes	No	0	9	7
162	R:R:F232	R:R:L237	3.65	Yes	No	0	9	6
163	R:R:C235	R:R:N271	3.15	No	Yes	0	7	9
164	R:R:F239	R:R:W243	5.01	Yes	Yes	0	6	4
165	R:R:F239	R:R:S264	2.64	Yes	No	0	6	5
166	R:R:F239	R:R:S268	5.28	Yes	No	0	6	8
167	R:R:F244	R:R:G240	3.01	Yes	No	0	5	7
168	R:R:I241	R:R:I246	2.94	No	No	0	6	4
169	R:R:L247	R:R:Q242	2.66	No	Yes	0	3	1
170	R:R:I260	R:R:Q242	8.23	No	Yes	0	3	1
171	R:R:H261	R:R:Q242	4.95	Yes	Yes	0	2	1
172	R:R:Q242	R:R:S264	7.22	Yes	No	0	1	5
173	R:R:F244	R:R:W243	9.02	Yes	Yes	0	5	4
174	R:R:H261	R:R:W243	4.23	Yes	Yes	0	2	4
175	R:R:I249	R:R:L245	4.28	No	No	0	1	5
176	R:R:I246	R:R:L256	5.71	No	Yes	0	4	2
177	R:R:F257	R:R:L247	2.44	No	No	0	3	3
178	R:R:S253	R:R:W250	2.47	No	No	8	1	1
179	R:R:L256	R:R:W250	3.42	Yes	No	8	2	1
180	R:R:L256	R:R:S253	3	Yes	No	8	2	1
181	R:R:D254	R:R:V255	5.84	No	No	0	1	1
182	R:R:I260	R:R:L256	2.85	No	Yes	0	3	2
183	R:R:H261	R:R:P262	3.05	Yes	No	0	2	1
184	R:R:H261	R:R:V265	2.77	Yes	Yes	0	2	4
185	R:R:L267	R:R:V263	2.98	No	No	0	7	5
186	R:R:N271	R:R:N275	9.54	Yes	Yes	0	9	9
187	R:R:N275	R:R:Y279	4.65	Yes	No	0	9	9
188	R:R:I278	R:R:Y279	9.67	No	No	0	8	9
189	R:R:F280	R:R:F281	4.29	Yes	No	4	8	6
190	R:R:L132	R:R:R208	2.43	No	No	0	6	7
191	R:R:I209	R:R:Y222	2.42	Yes	Yes	0	6	6
192	R:R:L218	R:R:Y222	2.34	No	Yes	0	7	6
193	R:R:L129	R:R:W133	2.28	No	No	0	6	5
194	R:R:L194	R:R:W190	2.28	No	No	0	8	7
195	R:R:F167	R:R:F183	2.14	No	No	0	4	4
196	R:R:G236	R:R:P238	2.03	No	No	0	7	9
197	R:R:C199	R:R:G200	1.96	No	No	0	5	4
198	R:R:C211	R:R:G212	1.96	No	No	0	5	5
199	R:R:A72	R:R:G73	1.95	No	No	0	9	5
200	R:R:A74	R:R:G116	1.95	No	No	0	9	9
201	R:R:A115	R:R:G116	1.95	No	No	0	7	9
202	R:R:G212	R:R:S213	1.86	No	No	0	5	7
203	R:R:A204	R:R:C128	1.81	No	No	0	6	8
204	R:R:P276	R:R:V51	1.77	No	Yes	0	9	9
205	R:R:G27	R:R:K28	1.74	No	No	0	1	2
206	R:R:C128	R:R:S201	1.72	No	No	0	8	8
207	R:R:G44	R:R:L79	1.71	No	Yes	0	9	7
208	R:R:G49	R:R:L52	1.71	No	No	0	6	8
209	R:R:G240	R:R:L191	1.71	No	No	0	7	7
210	R:R:C211	R:R:V207	1.71	No	No	0	5	5
211	R:R:A72	R:R:V51	1.7	No	Yes	0	9	9
212	R:R:G236	R:R:N271	1.7	No	Yes	0	7	9
213	R:R:C139	R:R:I135	1.64	No	No	0	7	6
214	R:R:L216	R:R:P217	1.64	No	No	0	4	5
215	R:R:S91	R:R:S98	1.63	No	No	0	2	6
216	R:R:S269	R:R:V265	1.62	No	Yes	0	5	4
217	R:R:S161	R:R:T110	1.6	No	No	0	7	2
218	R:R:A72	R:R:L52	1.58	No	No	0	9	8
219	R:R:A112	R:R:L77	1.58	No	No	0	7	6
220	R:R:T224	R:R:T228	1.57	No	No	0	7	7
221	R:R:I84	R:R:V88	1.54	No	No	0	5	3
222	R:R:I277	R:R:V282	1.54	No	No	0	6	7
223	R:R:L152	R:R:V148	1.49	No	No	0	4	4
224	R:R:L267	R:R:V266	1.49	No	No	0	7	5
225	R:R:D174	R:R:S173	1.47	No	No	0	2	1
226	R:R:D176	R:R:S177	1.47	No	No	0	3	3
227	R:R:L223	R:R:T219	1.47	No	No	0	6	5
228	R:R:I40	R:R:L270	1.43	No	No	0	7	6
229	R:R:I209	R:R:L221	1.43	Yes	No	0	6	8
230	R:R:I225	R:R:L226	1.43	No	No	0	7	5
231	L:L:?1	R:R:S177	1.42	Yes	No	0	0	3
232	R:R:C95	R:R:F94	1.4	No	No	0	4	3
233	R:R:A112	R:R:F78	1.39	No	Yes	0	7	6
234	R:R:L233	R:R:L234	1.38	No	No	0	7	5
235	R:R:H259	R:R:V255	1.38	No	No	0	2	1
236	R:R:P134	R:R:W133	1.35	No	No	0	9	5
237	R:R:F281	R:R:I277	1.26	No	No	0	6	6
238	R:R:M59	R:R:R58	1.24	No	No	0	6	5
239	R:R:F280	R:R:M59	1.24	Yes	No	0	8	6
240	R:R:F35	R:R:L90	1.22	No	No	0	4	4
241	R:R:D184	R:R:F185	1.19	Yes	No	0	3	3
242	R:R:L31	R:R:Y89	1.17	No	Yes	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.2229	7	3	0
2	R:R:L45	4.37	4	2	7
3	R:R:V51	2.505	4	4	9
4	R:R:L55	6.005	4	4	8
5	R:R:Y67	4.60833	6	1	7
6	R:R:F78	4.294	5	2	6
7	R:R:L79	4.02	4	2	7
8	R:R:Y89	2.4275	4	0	2
9	R:R:F101	13.06	4	7	4
10	R:R:F105	14.76	4	7	5
11	R:R:M109	3.51	4	2	4
12	R:R:Y113	4.2875	4	0	8
13	R:R:R141	4.82333	6	1	8
14	R:R:C180	4.39	4	3	9
15	R:R:D184	6.06667	6	3	3
16	R:R:I209	3.1925	4	0	6
17	R:R:Y222	5.5875	4	0	6
18	R:R:F232	3.994	5	0	9
19	R:R:F239	4.322	5	0	6
20	R:R:Q242	5.765	4	0	1
21	R:R:W243	6.1775	4	0	4
22	R:R:F244	7.048	5	3	5
23	R:R:W248	19.0875	4	3	3
24	R:R:L256	3.745	4	8	2
25	R:R:H261	3.75	4	0	2
26	R:R:V265	2.94	4	0	4
27	R:R:N271	4.3375	4	0	9
28	R:R:N275	5.265	4	6	9
29	R:R:F280	4.364	5	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W243	29.897	6.45	Yes	Yes	0	0	4
2	R:R:H261	R:R:W243	19.0686	4.23	Yes	Yes	0	2	4
3	R:R:H261	R:R:P262	26.8329	3.05	Yes	No	0	2	1
4	R:R:P262	R:R:T30	18.6359	3.5	No	No	5	1	3
5	R:R:T30	R:R:Y89	16.9826	2.5	No	Yes	0	3	2
6	R:R:H261	R:R:V265	16.7835	2.77	Yes	Yes	0	2	4
7	R:R:F239	R:R:W243	44.3002	5.01	Yes	Yes	0	6	4
8	R:R:F239	R:R:M109	58.1754	2.49	Yes	Yes	0	6	4
9	R:R:F78	R:R:M109	49.6927	4.98	Yes	Yes	2	6	4
10	R:R:F78	R:R:S272	59.0496	2.64	Yes	No	2	6	9
11	R:R:L79	R:R:S272	18.3848	7.51	Yes	No	2	7	9
12	R:R:L45	R:R:L79	12.2392	4.15	Yes	Yes	2	7	7
13	R:R:F239	R:R:Y113	55.9422	6.19	Yes	Yes	0	6	8
14	R:R:F78	R:R:Y113	61.4472	3.09	Yes	Yes	0	6	8
15	R:R:D75	R:R:S272	39.0721	10.31	No	No	2	9	9
16	R:R:D75	R:R:N48	39.1154	12.12	No	No	0	9	9
17	R:R:N48	R:R:P276	37.3236	8.15	No	No	0	9	9
18	R:R:P276	R:R:V51	35.5146	1.77	No	Yes	0	9	9
19	R:R:F280	R:R:V51	20.1593	3.93	Yes	Yes	4	8	9
20	R:R:F280	R:R:L55	10.3783	9.74	Yes	Yes	4	8	8
21	R:R:F81	R:R:M109	98.6843	2.49	No	Yes	0	5	4
22	R:R:F105	R:R:F81	85.0688	11.79	Yes	No	0	5	5
23	R:R:F105	R:R:T106	74.9156	10.38	Yes	No	0	5	5
24	R:R:F170	R:R:T106	73.0979	3.89	No	No	0	3	5
25	R:R:F170	R:R:T107	69.4452	3.89	No	No	0	3	4
26	R:R:S161	R:R:T107	67.6101	3.2	No	No	0	7	4
27	R:R:C111	R:R:S161	63.9228	5.16	No	No	0	5	7
28	R:R:C111	R:R:S157	63.2823	5.16	No	No	0	5	8
29	R:R:A115	R:R:S157	59.3179	3.42	No	No	0	7	8
30	R:R:A115	R:R:W154	53.0252	7.78	No	No	0	7	9
31	R:R:S70	R:R:W154	49.1041	2.47	No	No	0	9	9
32	R:R:C150	R:R:S70	37.869	5.16	No	No	1	7	9
33	R:R:C150	R:R:Y67	36.2763	2.69	No	Yes	1	7	7
34	R:R:E126	R:R:Y67	20.7219	6.73	No	Yes	1	9	7
35	R:R:E126	R:R:R141	14.0916	5.82	No	Yes	1	9	8
36	R:R:L117	R:R:Y113	100	3.52	No	Yes	0	8	8
37	R:R:F232	R:R:L117	98.7536	2.44	Yes	No	0	9	8
38	R:R:F232	R:R:L120	27.2224	4.87	Yes	No	0	9	9
39	R:R:L120	R:R:N275	23.0589	2.75	No	Yes	6	9	9
40	R:R:F81	R:R:V108	12.672	7.87	No	No	0	5	6
41	R:R:F104	R:R:V108	10.8284	3.93	No	No	0	4	6
42	R:R:F244	R:R:G240	11.0361	3.01	Yes	No	0	5	7
43	R:R:D184	R:R:F244	10.0407	5.97	Yes	Yes	3	3	5
44	R:R:F232	R:R:L198	70.6397	3.65	Yes	No	0	9	8
45	R:R:L198	R:R:S121	17.3548	3	No	No	0	8	7
46	R:R:L194	R:R:S121	15.2428	4.5	No	No	0	8	7
47	R:R:L198	R:R:V229	55.5094	4.47	No	No	0	8	8
48	R:R:S202	R:R:V229	53.7263	3.23	No	No	0	8	8
49	R:R:I225	R:R:S202	51.9346	3.1	No	No	0	7	8
50	R:R:I225	R:R:L206	48.5502	5.71	No	No	0	7	5
51	R:R:L206	R:R:Y222	46.7065	8.21	No	Yes	0	5	6
52	R:R:I209	R:R:Y222	41.0889	2.42	Yes	Yes	0	6	6
53	R:R:I209	R:R:L205	25.3873	4.28	Yes	No	0	6	8
54	R:R:L205	R:R:V131	23.3359	4.47	No	No	0	8	8
55	R:R:R208	R:R:V131	21.5269	2.62	No	No	0	7	8
56	R:R:L132	R:R:R208	19.4581	2.43	No	No	0	6	7
57	R:R:C128	R:R:L132	10.9842	3.17	No	No	0	8	6
58	R:R:L194	R:R:W190	13.1135	2.28	No	No	0	8	7
59	L:L:?1	R:R:S177	16.7489	1.42	Yes	No	0	0	3
60	R:R:D176	R:R:S177	12.6634	1.47	No	No	0	3	3
61	R:R:D176	R:R:W179	10.5947	4.47	No	No	0	3	2
62	R:R:F195	R:R:F232	10.9842	5.36	No	Yes	0	6	9
63	R:R:I209	R:R:S213	13.1308	4.64	Yes	No	0	6	7
64	R:R:N275	R:R:Y279	10.5341	4.65	Yes	No	0	9	9
65	R:R:N271	R:R:N275	10.9842	9.54	Yes	Yes	0	9	9
66	R:R:F239	R:R:S264	15.8054	2.64	Yes	No	0	6	5
67	R:R:Q242	R:R:S264	14.4032	7.22	Yes	No	0	1	5
68	R:R:I260	R:R:Q242	13.78	8.23	No	Yes	0	3	1
69	R:R:I260	R:R:L256	11.6593	2.85	No	Yes	0	3	2
70	R:R:G240	R:R:Y113	13.4251	4.35	No	Yes	0	7	8
71	R:R:F78	R:R:Q82	14.4292	9.37	Yes	No	2	6	5
72	R:R:Q82	R:R:V265	23.2407	4.3	No	Yes	0	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:E164	2.5	3	Yes	No	0	4	0	1
L:L:?1	R:R:C180	3	3	Yes	Yes	0	9	0	1
L:L:?1	R:R:D184	10.25	3	Yes	Yes	0	3	0	1
L:L:?1	R:R:W243	6.45	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:L247	6.54	3	Yes	No	0	3	0	1
L:L:?1	R:R:W248	48.4	3	Yes	Yes	0	3	0	1
R:R:D184	R:R:E164	6.5	3	Yes	No	3	4	1	1
R:R:E164	R:R:F244	8.16	3	No	Yes	4	5	1	2
R:R:C168	R:R:C180	7.28	0	No	Yes	6	9	2	1
R:R:G178	R:R:S177	3.71	0	No	No	3	3	2	1
R:R:C180	R:R:D184	4.67	3	Yes	Yes	9	3	1	1
R:R:C180	R:R:W248	2.61	3	Yes	Yes	9	3	1	1
R:R:Q181	R:R:W248	17.52	0	No	Yes	3	3	2	1
R:R:D184	R:R:F244	5.97	3	Yes	Yes	3	5	1	2
R:R:D184	R:R:W248	7.82	3	Yes	Yes	3	3	1	1
R:R:F239	R:R:W243	5.01	0	Yes	Yes	6	4	2	1
R:R:L247	R:R:Q242	2.66	0	No	Yes	3	1	1	2
R:R:H261	R:R:Q242	4.95	0	Yes	Yes	2	1	2	2
R:R:F244	R:R:W243	9.02	3	Yes	Yes	5	4	2	1
R:R:H261	R:R:W243	4.23	0	Yes	Yes	2	4	2	1
R:R:F257	R:R:L247	2.44	0	No	No	3	3	2	1
R:R:D176	R:R:S177	1.47	0	No	No	3	3	2	1
L:L:?1	R:R:S177	1.42	3	Yes	No	0	3	0	1
R:R:D184	R:R:F185	1.19	3	Yes	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7S8O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	229
Number of Links	242
Number of Hubs	29
Number of Links mediated by Hubs	107
Number of Communities	8
Number of Nodes involved in Communities	41
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	26230
Length Of Smallest Path	3
Average Path Length	14.4754
Length of Longest Path	36
Minimum Path Strength	1.24
Average Path Strength	4.84323
Maximum Path Strength	32.96
Minimum Path Correlation	0.7
Average Path Correlation	0.91904
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.836
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.7077
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • mast cell secretagogue receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • sleep • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • sleep • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • establishment of organelle localization • regulated exocytosis • cellular localization • response to stimulus • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • system process • sensory perception • nervous system process • sensory perception of pain • cellular anatomical structure • periplasmic space • membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cellular component organization or biogenesis • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8IU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8IU
Name	(3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine
Synonyms
Identifier
Formula	C18 H21 N5
Molecular Weight	307.393
SMILES
PubChem	95882507
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	1
Total Bonds	47
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7S8O_nogp_Chain_R G K E T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G S R G L P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W S D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	10.1038/s41586-021-04077-y
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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