psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E164	3.75	Yes	Yes	1	0	4
2	L:L:?1	R:R:C168	4.5	Yes	No	1	0	6
3	L:L:?1	R:R:F170	3.45	Yes	No	0	0	3
4	L:L:?1	R:R:S177	5.67	Yes	No	0	0	3
5	L:L:?1	R:R:C180	4.5	Yes	No	1	0	9
6	L:L:?1	R:R:D184	12.82	Yes	Yes	1	0	3
7	L:L:?1	R:R:W243	6.45	Yes	Yes	1	0	4
8	L:L:?1	R:R:W248	23.66	Yes	Yes	1	0	3
9	R:R:P33	R:R:T30	6.99	No	No	0	4	3
10	R:R:T30	R:R:Y89	4.99	No	Yes	0	3	2
11	R:R:P262	R:R:T30	3.5	No	No	0	1	3
12	R:R:F35	R:R:L31	10.96	No	No	0	4	3
13	R:R:L31	R:R:Y89	3.52	No	Yes	0	3	2
14	R:R:F94	R:R:L31	6.09	No	No	0	3	3
15	R:R:I32	R:R:P33	5.08	No	No	0	5	4
16	R:R:C86	R:R:V34	3.42	No	No	0	5	4
17	R:R:V34	R:R:Y89	8.83	No	Yes	0	4	2
18	R:R:F35	R:R:L90	7.31	No	No	0	4	4
19	R:R:I37	R:R:V265	3.07	No	No	0	6	4
20	R:R:I37	R:R:V266	3.07	No	No	0	6	5
21	R:R:C86	R:R:L38	7.94	No	No	0	5	5
22	R:R:F39	R:R:I40	2.51	No	No	0	5	7
23	R:R:F39	R:R:V43	6.55	No	No	0	5	5
24	R:R:I40	R:R:S273	3.1	No	No	0	7	8
25	R:R:A41	R:R:I83	3.25	No	No	0	5	6
26	R:R:F76	R:R:L45	9.74	Yes	Yes	2	7	7
27	R:R:L45	R:R:L79	2.77	Yes	Yes	2	7	7
28	R:R:C80	R:R:L45	3.17	No	Yes	2	4	7
29	R:R:F50	R:R:V46	5.24	No	No	0	5	5
30	R:R:D75	R:R:N48	17.5	Yes	Yes	0	9	9
31	R:R:F76	R:R:N48	7.25	Yes	Yes	0	7	9
32	R:R:G49	R:R:L52	3.42	No	No	0	6	8
33	R:R:L55	R:R:V51	2.98	Yes	Yes	3	8	9
34	R:R:F280	R:R:V51	2.62	No	Yes	3	8	9
35	R:R:F281	R:R:V51	2.62	No	Yes	3	6	9
36	R:R:L54	R:R:W53	3.42	No	No	3	8	6
37	R:R:R58	R:R:W53	7	Yes	No	3	5	6
38	R:R:L54	R:R:R58	6.07	No	Yes	3	8	5
39	R:R:L54	R:R:M59	5.65	No	No	3	8	6
40	R:R:L55	R:R:M59	2.83	Yes	No	3	8	6
41	R:R:L55	R:R:S65	7.51	Yes	No	0	8	8
42	R:R:L55	R:R:V68	2.98	Yes	No	0	8	8
43	R:R:F280	R:R:L55	9.74	No	Yes	3	8	8
44	R:R:F57	R:R:R58	3.21	No	Yes	0	5	5
45	R:R:M59	R:R:R58	2.48	No	Yes	3	6	5
46	R:R:R61	R:R:S65	2.64	No	No	0	7	8
47	R:R:R61	R:R:V66	2.62	No	No	0	7	6
48	R:R:F64	R:R:N62	2.42	No	No	0	7	8
49	R:R:A63	R:R:R141	2.77	No	Yes	0	7	8
50	R:R:F64	R:R:V68	5.24	No	No	0	7	8
51	R:R:F64	R:R:V123	2.62	No	No	0	7	9
52	R:R:S146	R:R:V66	4.85	No	No	0	9	6
53	R:R:M119	R:R:Y67	2.39	Yes	Yes	5	6	7
54	R:R:T122	R:R:Y67	6.24	No	Yes	0	7	7
55	R:R:V123	R:R:Y67	3.79	No	Yes	0	9	7
56	R:R:E126	R:R:Y67	5.61	No	Yes	5	9	7
57	R:R:S146	R:R:Y67	7.63	No	Yes	0	9	7
58	R:R:V149	R:R:Y67	3.79	No	Yes	0	6	7
59	R:R:C150	R:R:Y67	2.69	No	Yes	5	7	7
60	R:R:M119	R:R:S70	7.67	Yes	No	0	6	9
61	R:R:S70	R:R:W154	6.18	No	Yes	0	9	9
62	R:R:L120	R:R:L71	2.77	Yes	No	4	9	9
63	R:R:L71	R:R:N275	10.98	No	No	4	9	9
64	R:R:A74	R:R:W154	2.59	No	Yes	0	9	9
65	R:R:D75	R:R:L79	5.43	Yes	Yes	2	9	7
66	R:R:D75	R:R:S272	10.31	Yes	No	2	9	9
67	R:R:D75	R:R:P276	3.22	Yes	No	0	9	9
68	R:R:C80	R:R:F76	2.79	No	Yes	2	4	7
69	R:R:F81	R:R:L77	3.65	Yes	No	2	5	6
70	R:R:L77	R:R:V108	4.47	No	No	2	6	6
71	R:R:A112	R:R:L77	4.73	No	No	0	7	6
72	R:R:F78	R:R:L79	2.44	Yes	Yes	0	6	7
73	R:R:F78	R:R:Q82	3.51	Yes	No	0	6	5
74	R:R:F78	R:R:M109	3.73	Yes	No	0	6	4
75	R:R:L79	R:R:S272	3	Yes	No	2	7	9
76	R:R:F81	R:R:I84	2.51	Yes	No	0	5	5
77	R:R:F81	R:R:V108	9.18	Yes	No	2	5	6
78	R:R:Q82	R:R:V265	5.73	No	No	0	5	4
79	R:R:F101	R:R:I84	3.77	Yes	No	0	4	5
80	R:R:F105	R:R:I84	3.77	No	No	0	5	5
81	R:R:C86	R:R:L90	3.17	No	No	0	5	4
82	R:R:I99	R:R:V88	4.61	No	No	6	1	3
83	R:R:F101	R:R:V88	7.87	Yes	No	6	4	3
84	R:R:L90	R:R:Y89	3.52	No	Yes	0	4	2
85	R:R:N92	R:R:S98	7.45	No	No	0	3	6
86	R:R:F93	R:R:F94	9.65	No	No	0	1	3
87	R:R:F101	R:R:I99	2.51	Yes	No	6	4	1
88	R:R:F101	R:R:P102	4.33	Yes	No	0	4	5
89	R:R:F170	R:R:S103	3.96	No	No	0	3	5
90	R:R:F104	R:R:V108	3.93	No	No	0	4	6
91	R:R:F170	R:R:T106	5.19	No	No	0	3	5
92	R:R:S161	R:R:T107	3.2	Yes	No	0	7	4
93	R:R:C111	R:R:W154	2.61	Yes	Yes	0	5	9
94	R:R:C111	R:R:S157	5.16	Yes	No	0	5	8
95	R:R:C111	R:R:L158	3.17	Yes	No	7	5	4
96	R:R:C111	R:R:S161	5.16	Yes	Yes	7	5	7
97	R:R:L114	R:R:Y113	2.34	No	Yes	0	6	8
98	R:R:L117	R:R:Y113	4.69	No	Yes	0	8	8
99	R:R:F239	R:R:Y113	9.28	Yes	Yes	0	6	8
100	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
101	R:R:L114	R:R:S157	3	No	No	0	6	8
102	R:R:A115	R:R:W154	7.78	No	Yes	0	7	9
103	R:R:L117	R:R:L191	2.77	No	No	0	8	7
104	R:R:F232	R:R:L117	3.65	Yes	No	0	9	8
105	R:R:L153	R:R:S118	7.51	No	No	0	7	8
106	R:R:L194	R:R:S118	3	No	No	0	8	8
107	R:R:C150	R:R:M119	4.86	No	Yes	5	7	6
108	R:R:L153	R:R:M119	2.83	No	Yes	0	7	6
109	R:R:F232	R:R:L120	3.65	Yes	Yes	4	9	9
110	R:R:L120	R:R:N275	5.49	Yes	No	4	9	9
111	R:R:L120	R:R:Y279	3.52	Yes	Yes	4	9	9
112	R:R:L194	R:R:S121	6.01	No	No	0	8	7
113	R:R:R127	R:R:V123	2.62	No	No	0	9	9
114	R:R:L198	R:R:S124	3	No	No	0	8	9
115	R:R:S124	R:R:S201	4.89	No	No	0	9	8
116	R:R:S124	R:R:S202	3.26	No	No	0	9	8
117	R:R:E126	R:R:Y137	4.49	No	Yes	5	9	7
118	R:R:E126	R:R:R141	5.82	No	Yes	5	9	8
119	R:R:R127	R:R:T224	3.88	No	No	0	9	7
120	R:R:C128	R:R:L132	3.17	No	No	0	8	6
121	R:R:C128	R:R:S201	3.44	No	No	0	8	8
122	R:R:S130	R:R:V131	3.23	No	No	0	8	8
123	R:R:S130	R:R:Y137	7.63	No	Yes	0	8	7
124	R:R:L205	R:R:V131	4.47	No	No	0	8	8
125	R:R:I209	R:R:V131	4.61	No	No	0	6	8
126	R:R:L132	R:R:R208	2.43	No	No	0	6	7
127	R:R:R140	R:R:W136	8	No	No	0	6	6
128	R:R:R141	R:R:Y137	5.14	Yes	Yes	5	8	7
129	R:R:C139	R:R:R138	2.79	No	No	0	7	7
130	R:R:P142	R:R:R141	2.88	No	Yes	0	7	8
131	R:R:L145	R:R:R141	6.07	No	Yes	0	5	8
132	R:R:R141	R:R:S146	3.95	Yes	No	0	8	9
133	R:R:L153	R:R:V149	2.98	No	No	0	7	6
134	R:R:L158	R:R:S161	3	No	Yes	7	4	7
135	R:R:I162	R:R:L158	4.28	No	No	0	4	4
136	R:R:L159	R:R:L163	5.54	No	No	0	4	8
137	R:R:I186	R:R:L160	2.85	No	No	0	6	4
138	R:R:L160	R:R:T187	5.9	No	No	0	4	4
139	R:R:F183	R:R:L163	4.87	No	No	0	4	8
140	R:R:D184	R:R:E164	7.8	Yes	Yes	1	3	4
141	R:R:E164	R:R:F244	3.5	Yes	Yes	1	4	5
142	R:R:F167	R:R:K166	6.2	No	No	0	4	3
143	R:R:K166	R:R:S173	9.18	No	No	0	3	1
144	R:R:F167	R:R:W179	19.04	No	No	0	4	2
145	R:R:F167	R:R:F183	4.29	No	No	0	4	4
146	R:R:C168	R:R:C180	7.28	No	No	1	6	9
147	R:R:D176	R:R:W179	8.93	No	No	0	3	2
148	R:R:G178	R:R:S177	3.71	No	No	0	3	3
149	R:R:C180	R:R:W248	5.22	No	Yes	1	9	3
150	R:R:Q181	R:R:W248	18.62	No	Yes	0	3	3
151	R:R:D184	R:R:F244	4.78	Yes	Yes	1	3	5
152	R:R:D184	R:R:W248	6.7	Yes	Yes	1	3	3
153	R:R:F185	R:R:L245	4.87	No	No	0	3	5
154	R:R:F244	R:R:T187	10.38	Yes	No	0	5	4
155	R:R:A188	R:R:L245	4.73	No	No	0	5	5
156	R:R:L194	R:R:W190	3.42	No	No	0	8	7
157	R:R:L191	R:R:L237	2.77	No	No	0	7	6
158	R:R:F193	R:R:V197	2.62	No	No	0	5	6
159	R:R:F195	R:R:L198	2.44	Yes	No	4	6	8
160	R:R:C199	R:R:F195	4.19	No	Yes	0	5	6
161	R:R:F195	R:R:V229	2.62	Yes	No	0	6	8
162	R:R:F195	R:R:F232	7.5	Yes	Yes	4	6	9
163	R:R:F195	R:R:L233	8.53	Yes	No	0	6	7
164	R:R:F232	R:R:L198	4.87	Yes	No	4	9	8
165	R:R:I225	R:R:S202	3.1	No	No	0	7	8
166	R:R:L206	R:R:Y222	3.52	No	Yes	0	5	6
167	R:R:L210	R:R:Y222	3.52	No	Yes	0	5	6
168	R:R:L218	R:R:Y222	11.72	No	Yes	0	7	6
169	R:R:R220	R:R:T224	2.59	No	No	0	8	7
170	R:R:L221	R:R:Y222	4.69	No	Yes	0	8	6
171	R:R:T228	R:R:Y279	2.5	No	Yes	0	7	9
172	R:R:F232	R:R:L237	2.44	Yes	No	0	9	6
173	R:R:L233	R:R:L234	4.15	No	No	0	7	5
174	R:R:C235	R:R:N271	3.15	No	No	0	7	9
175	R:R:F239	R:R:Q242	2.34	Yes	Yes	1	6	1
176	R:R:F239	R:R:W243	7.02	Yes	Yes	1	6	4
177	R:R:F239	R:R:H261	3.39	Yes	Yes	1	6	2
178	R:R:F239	R:R:S268	3.96	Yes	No	0	6	8
179	R:R:F244	R:R:G240	3.01	Yes	No	0	5	7
180	R:R:I241	R:R:I246	2.94	No	No	0	6	4
181	R:R:L247	R:R:Q242	2.66	No	Yes	0	3	1
182	R:R:I260	R:R:Q242	2.74	No	Yes	0	3	1
183	R:R:H261	R:R:Q242	9.89	Yes	Yes	1	2	1
184	R:R:Q242	R:R:S264	7.22	Yes	No	0	1	5
185	R:R:F244	R:R:W243	5.01	Yes	Yes	1	5	4
186	R:R:H261	R:R:W243	3.17	Yes	Yes	1	2	4
187	R:R:L256	R:R:V255	2.98	No	No	0	2	1
188	R:R:F257	R:R:H261	6.79	No	Yes	0	3	2
189	R:R:H261	R:R:P262	4.58	Yes	No	0	2	1
190	R:R:N275	R:R:Y279	10.47	No	Yes	4	9	9
191	R:R:F281	R:R:I277	2.51	No	No	0	6	6
192	R:R:I278	R:R:Y279	2.42	No	Yes	0	8	9
193	R:R:F280	R:R:F281	6.43	No	No	3	8	6
194	R:R:N92	R:R:Y89	2.33	No	Yes	0	3	2
195	R:R:E164	R:R:F183	2.33	Yes	No	0	4	4
196	R:R:L129	R:R:W133	2.28	No	No	0	6	5
197	R:R:L132	R:R:W133	2.28	No	No	0	6	5
198	R:R:L156	R:R:W190	2.28	No	No	0	6	7
199	R:R:H144	R:R:R143	2.26	No	No	0	5	5
200	R:R:R141	R:R:R143	2.13	Yes	No	0	8	5
201	R:R:G169	R:R:G175	2.11	No	No	0	1	3
202	R:R:F78	R:R:Y113	2.06	Yes	Yes	0	6	8
203	R:R:G236	R:R:P238	2.03	No	No	0	7	9
204	R:R:F193	R:R:W190	2	No	No	0	5	7
205	R:R:C199	R:R:G200	1.96	No	No	0	5	4
206	R:R:A74	R:R:G116	1.95	No	No	0	9	9
207	R:R:A115	R:R:G116	1.95	No	No	0	7	9
208	R:R:W136	R:R:Y137	1.93	No	Yes	0	6	7
209	R:R:G44	R:R:S273	1.86	No	No	0	9	8
210	R:R:G47	R:R:V46	1.84	No	No	0	8	5
211	R:R:G165	R:R:T107	1.82	No	No	0	3	4
212	R:R:A204	R:R:C128	1.81	No	No	0	6	8
213	R:R:P238	R:R:S264	1.78	No	No	0	9	5
214	R:R:G165	R:R:L171	1.71	No	No	0	3	1
215	R:R:G200	R:R:L203	1.71	No	No	0	4	5
216	R:R:G44	R:R:N48	1.7	No	Yes	0	9	9
217	R:R:G49	R:R:N48	1.7	No	Yes	0	6	9
218	R:R:A72	R:R:V51	1.7	No	Yes	0	9	9
219	R:R:G236	R:R:N271	1.7	No	No	0	7	9
220	R:R:D174	R:R:G175	1.68	No	No	0	2	3
221	R:R:C95	R:R:I97	1.64	No	No	0	4	5
222	R:R:C139	R:R:I135	1.64	No	No	0	7	6
223	R:R:S269	R:R:V265	1.62	No	No	0	5	4
224	R:R:S161	R:R:T110	1.6	Yes	No	0	7	2
225	R:R:T125	R:R:V197	1.59	No	No	0	7	6
226	R:R:C235	R:R:L267	1.59	No	No	0	7	7
227	R:R:C235	R:R:L270	1.59	No	No	0	7	6
228	R:R:A41	R:R:L45	1.58	No	Yes	2	5	7
229	R:R:A41	R:R:L79	1.58	No	Yes	2	5	7
230	R:R:I186	R:R:T182	1.52	No	No	0	6	2
231	R:R:F76	R:R:G73	1.51	Yes	No	0	7	5
232	R:R:L203	R:R:V207	1.49	No	No	0	5	5
233	R:R:L227	R:R:V231	1.49	No	No	0	7	7
234	R:R:N271	R:R:V231	1.48	No	No	0	9	7
235	R:R:D174	R:R:S173	1.47	No	No	0	2	1
236	R:R:L223	R:R:T219	1.47	No	No	0	6	5
237	R:R:C258	R:R:H259	1.47	No	No	0	1	2
238	R:R:I32	R:R:L36	1.43	No	No	0	5	5
239	R:R:I83	R:R:L42	1.43	No	No	0	6	5
240	R:R:I83	R:R:L87	1.43	No	No	0	6	4
241	R:R:I209	R:R:L218	1.43	No	No	0	6	7
242	R:R:I209	R:R:L221	1.43	No	No	0	6	8
243	R:R:I225	R:R:L221	1.43	No	No	0	7	8
244	R:R:I241	R:R:L245	1.43	No	No	0	6	5
245	R:R:I260	R:R:L256	1.43	No	No	0	3	2
246	R:R:C80	R:R:F81	1.4	No	Yes	2	4	5
247	R:R:C139	R:R:R140	1.39	No	No	0	7	6
248	R:R:L52	R:R:L69	1.38	No	No	0	8	7
249	R:R:L55	R:R:L69	1.38	Yes	No	0	8	7
250	R:R:L230	R:R:L234	1.38	No	No	0	5	5
251	R:R:E29	R:R:K28	1.35	No	No	0	1	2
252	R:R:P134	R:R:W133	1.35	No	No	0	9	5
253	R:R:R220	R:R:V282	1.31	No	No	0	8	7
254	R:R:F93	R:R:K28	1.24	No	No	0	1	2
255	R:R:I246	R:R:W250	1.17	No	No	0	4	1
256	R:R:I249	R:R:W250	1.17	No	No	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.1	8	1	0
2	R:R:L45	4.315	4	2	7
3	R:R:N48	7.0375	4	0	9
4	R:R:V51	2.48	4	3	9
5	R:R:L55	4.57	6	3	8
6	R:R:R58	4.69	4	3	5
7	R:R:Y67	4.59143	7	5	7
8	R:R:D75	9.115	4	2	9
9	R:R:F76	5.3225	4	2	7
10	R:R:F78	2.935	4	0	6
11	R:R:L79	3.044	5	2	7
12	R:R:F81	4.185	4	2	5
13	R:R:Y89	4.638	5	0	2
14	R:R:F101	4.62	4	6	4
15	R:R:C111	4.025	4	7	5
16	R:R:Y113	4.544	5	0	8
17	R:R:M119	4.4375	4	5	6
18	R:R:L120	3.8575	4	4	9
19	R:R:Y137	4.7975	4	5	7
20	R:R:R141	4.10857	7	5	8
21	R:R:W154	4.79	4	0	9
22	R:R:S161	3.24	4	7	7
23	R:R:E164	4.345	4	1	4
24	R:R:D184	8.025	4	1	3
25	R:R:F195	5.056	5	4	6
26	R:R:Y222	5.8625	4	0	6
27	R:R:F232	4.422	5	4	9
28	R:R:F239	5.198	5	1	6
29	R:R:Q242	4.97	5	1	1
30	R:R:W243	5.4125	4	1	4
31	R:R:F244	5.336	5	1	5
32	R:R:W248	13.55	4	1	3
33	R:R:H261	5.564	5	1	2
34	R:R:Y279	4.7275	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W243	35.8289	6.45	Yes	Yes	1	0	4
2	R:R:H261	R:R:W243	19.6206	3.17	Yes	Yes	1	2	4
3	R:R:H261	R:R:P262	57.8177	4.58	Yes	No	0	2	1
4	R:R:P262	R:R:T30	55.2075	3.5	No	No	0	1	3
5	R:R:T30	R:R:Y89	45.0216	4.99	No	Yes	0	3	2
6	R:R:L31	R:R:Y89	17.9017	3.52	No	Yes	0	3	2
7	R:R:F94	R:R:L31	12.2231	6.09	No	No	0	3	3
8	R:R:L90	R:R:Y89	11.1281	3.52	No	Yes	0	4	2
9	R:R:F239	R:R:W243	30.2776	7.02	Yes	Yes	1	6	4
10	R:R:F239	R:R:Y113	100	9.28	Yes	Yes	0	6	8
11	R:R:F78	R:R:Y113	92.7298	2.06	Yes	Yes	0	6	8
12	R:R:F78	R:R:Q82	14.0693	3.51	Yes	No	0	6	5
13	R:R:Q82	R:R:V265	11.2427	5.73	No	No	0	5	4
14	R:R:F78	R:R:L79	82.1874	2.44	Yes	Yes	0	6	7
15	R:R:D75	R:R:L79	45.2763	5.43	Yes	Yes	2	9	7
16	R:R:D75	R:R:N48	43.7357	17.5	Yes	Yes	0	9	9
17	R:R:G44	R:R:N48	15.2024	1.7	No	Yes	0	9	9
18	R:R:G44	R:R:S273	12.2103	1.86	No	No	0	9	8
19	R:R:A41	R:R:L79	10.7079	1.58	No	Yes	2	5	7
20	R:R:A41	R:R:I83	10.0204	3.25	No	No	0	5	6
21	R:R:L45	R:R:L79	27.8584	2.77	Yes	Yes	2	7	7
22	R:R:C80	R:R:L45	22.7527	3.17	No	Yes	2	4	7
23	R:R:G49	R:R:N48	50.4074	1.7	No	Yes	0	6	9
24	R:R:G49	R:R:L52	49.3634	3.42	No	No	0	6	8
25	R:R:L52	R:R:L69	48.6504	1.38	No	No	0	8	7
26	R:R:L55	R:R:L69	48.1538	1.38	Yes	No	0	8	7
27	R:R:L55	R:R:V51	12.7196	2.98	Yes	Yes	3	8	9
28	R:R:L55	R:R:M59	19.1622	2.83	Yes	No	3	8	6
29	R:R:L55	R:R:S65	15.4826	7.51	Yes	No	0	8	8
30	R:R:L55	R:R:V68	24.0514	2.98	Yes	No	0	8	8
31	R:R:L114	R:R:Y113	86.3382	2.34	No	Yes	0	6	8
32	R:R:L114	R:R:S157	85.0267	3	No	No	0	6	8
33	R:R:C111	R:R:S157	84.11	5.16	Yes	No	0	5	8
34	R:R:C111	R:R:W154	77.0817	2.61	Yes	Yes	0	5	9
35	R:R:S70	R:R:W154	72.3071	6.18	No	Yes	0	9	9
36	R:R:M119	R:R:S70	71.3267	7.67	Yes	No	0	6	9
37	R:R:M119	R:R:Y67	59.6129	2.39	Yes	Yes	5	6	7
38	R:R:S146	R:R:Y67	15.6735	7.63	No	Yes	0	9	7
39	R:R:S146	R:R:V66	16.4375	4.85	No	No	0	9	6
40	R:R:R61	R:R:V66	14.8714	2.62	No	No	0	7	6
41	R:R:R61	R:R:S65	14.464	2.64	No	No	0	7	8
42	R:R:V123	R:R:Y67	34.0336	3.79	No	Yes	0	9	7
43	R:R:F64	R:R:V123	26.2923	2.62	No	No	0	7	9
44	R:R:E126	R:R:Y67	40.3361	5.61	No	Yes	5	9	7
45	R:R:R141	R:R:S146	22.1161	3.95	Yes	No	0	8	9
46	R:R:L153	R:R:M119	27.7438	2.83	No	Yes	0	7	6
47	R:R:L153	R:R:V149	10.8734	2.98	No	No	0	7	6
48	R:R:L117	R:R:Y113	78.8261	4.69	No	Yes	0	8	8
49	R:R:F232	R:R:L117	73.0074	3.65	Yes	No	0	9	8
50	R:R:F232	R:R:L120	16.3611	3.65	Yes	Yes	4	9	9
51	R:R:C80	R:R:F81	29.2972	1.4	No	Yes	2	4	5
52	R:R:F81	R:R:I84	15.89	2.51	Yes	No	0	5	5
53	R:R:F101	R:R:I84	10.5169	3.77	Yes	No	0	4	5
54	R:R:C111	R:R:S161	14.5022	5.16	Yes	Yes	7	5	7
55	L:L:?1	R:R:E164	10.2241	3.75	Yes	Yes	1	0	4
56	R:R:E164	R:R:F244	33.779	3.5	Yes	Yes	1	4	5
57	R:R:F244	R:R:G240	41.151	3.01	Yes	No	0	5	7
58	R:R:F244	R:R:W243	13.0761	5.01	Yes	Yes	1	5	4
59	R:R:L153	R:R:S118	31.589	7.51	No	No	0	7	8
60	R:R:L194	R:R:S118	27.6802	3	No	No	0	8	8
61	R:R:F232	R:R:L198	39.9796	4.87	Yes	No	4	9	8
62	R:R:L198	R:R:S124	42.4497	3	No	No	0	8	9
63	R:R:S124	R:R:S201	23.1602	4.89	No	No	0	9	8
64	R:R:S124	R:R:S202	30.0484	3.26	No	No	0	9	8
65	R:R:C128	R:R:S201	20.2699	3.44	No	No	0	8	8
66	R:R:C128	R:R:L132	14.7313	3.17	No	No	0	8	6
67	R:R:E126	R:R:Y137	29.3481	4.49	No	Yes	5	9	7
68	R:R:S130	R:R:Y137	27.1327	7.63	No	Yes	0	8	7
69	R:R:I225	R:R:S202	28.9789	3.1	No	No	0	7	8
70	R:R:I225	R:R:L221	28.4696	1.43	No	No	0	7	8
71	R:R:I209	R:R:L221	23.8095	1.43	No	No	0	6	8
72	R:R:I209	R:R:V131	26.3942	4.61	No	No	0	6	8
73	R:R:S130	R:R:V131	25.8212	3.23	No	No	0	8	8
74	R:R:W136	R:R:Y137	17.3669	1.93	No	Yes	0	6	7
75	R:R:R140	R:R:W136	13.9419	8	No	No	0	6	6
76	R:R:C139	R:R:R140	10.4915	1.39	No	No	0	7	6
77	R:R:E164	R:R:F183	40.3234	2.33	Yes	No	0	4	4
78	R:R:F244	R:R:T187	12.7196	10.38	Yes	No	0	5	4
79	R:R:F167	R:R:F183	29.6155	4.29	No	No	0	4	4
80	R:R:F167	R:R:K166	18.7038	6.2	No	No	0	4	3
81	R:R:K166	R:R:S173	15.0115	9.18	No	No	0	3	1
82	R:R:L194	R:R:W190	19.7861	3.42	No	No	0	8	7
83	R:R:F193	R:R:W190	11.7774	2	No	No	0	5	7
84	R:R:F195	R:R:F232	20.6137	7.5	Yes	Yes	4	6	9
85	R:R:C199	R:R:F195	11.3445	4.19	No	Yes	0	5	6
86	R:R:L221	R:R:Y222	11.3063	4.69	No	Yes	0	8	6
87	R:R:R127	R:R:V123	10.988	2.62	No	No	0	9	9
88	R:R:F239	R:R:Q242	36.1599	2.34	Yes	Yes	1	6	1
89	R:R:Q242	R:R:S264	31.4107	7.22	Yes	No	0	1	5
90	R:R:P238	R:R:S264	28.1003	1.78	No	No	0	9	5
91	R:R:G236	R:R:P238	24.6753	2.03	No	No	0	7	9
92	R:R:G236	R:R:N271	21.2249	1.7	No	No	0	7	9
93	R:R:C235	R:R:N271	10.7207	3.15	No	No	0	7	9
94	R:R:H261	R:R:Q242	11.4209	9.89	Yes	Yes	1	2	1
95	R:R:I260	R:R:Q242	10.3259	2.74	No	Yes	0	3	1
96	R:R:D174	R:R:S173	11.2936	1.47	No	No	0	2	1
97	R:R:G240	R:R:Y113	42.8062	4.35	No	Yes	0	7	8
98	R:R:V149	R:R:Y67	11.5865	3.79	No	Yes	0	6	7
99	R:R:F239	R:R:H261	46.2439	3.39	Yes	Yes	1	6	2
100	R:R:F64	R:R:V68	23.2366	5.24	No	No	0	7	8
101	R:R:F76	R:R:N48	13.8401	7.25	Yes	Yes	0	7	9
102	R:R:R141	R:R:Y137	11.5355	5.14	Yes	Yes	5	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:E164	3.75	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:C168	4.5	1	Yes	No	0	6	0	1
L:L:?1	R:R:F170	3.45	1	Yes	No	0	3	0	1
L:L:?1	R:R:S177	5.67	1	Yes	No	0	3	0	1
L:L:?1	R:R:C180	4.5	1	Yes	No	0	9	0	1
L:L:?1	R:R:D184	12.82	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:W243	6.45	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:W248	23.66	1	Yes	Yes	0	3	0	1
R:R:F170	R:R:S103	3.96	0	No	No	3	5	1	2
R:R:F170	R:R:T106	5.19	0	No	No	3	5	1	2
R:R:D184	R:R:E164	7.8	1	Yes	Yes	3	4	1	1
R:R:E164	R:R:F244	3.5	1	Yes	Yes	4	5	1	2
R:R:C168	R:R:C180	7.28	1	No	No	6	9	1	1
R:R:G178	R:R:S177	3.71	0	No	No	3	3	2	1
R:R:C180	R:R:W248	5.22	1	No	Yes	9	3	1	1
R:R:Q181	R:R:W248	18.62	0	No	Yes	3	3	2	1
R:R:D184	R:R:F244	4.78	1	Yes	Yes	3	5	1	2
R:R:D184	R:R:W248	6.7	1	Yes	Yes	3	3	1	1
R:R:F239	R:R:W243	7.02	1	Yes	Yes	6	4	2	1
R:R:F239	R:R:H261	3.39	1	Yes	Yes	6	2	2	2
R:R:F244	R:R:W243	5.01	1	Yes	Yes	5	4	2	1
R:R:H261	R:R:W243	3.17	1	Yes	Yes	2	4	2	1
R:R:E164	R:R:F183	2.33	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7S8N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.34
Number of Linked Nodes	227
Number of Links	256
Number of Hubs	34
Number of Links mediated by Hubs	127
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	27659
Length Of Smallest Path	3
Average Path Length	11.7007
Length of Longest Path	24
Minimum Path Strength	1.17
Average Path Strength	4.30471
Maximum Path Strength	16.2433
Minimum Path Correlation	0.7
Average Path Correlation	0.917268
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.6581
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.7199
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8IU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8IU
Name	(3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine
Synonyms
Identifier
Formula	C18 H21 N5
Molecular Weight	307.393
SMILES
PubChem	95882507
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	1
Total Bonds	47
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7S8N_nogp_Chain_R K E T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	10.1038/s41586-021-04077-y
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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