psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P262	R:R:V34	3.53	No	No	0	1	4
2	R:R:I37	R:R:Q82	10.98	Yes	No	0	6	5
3	R:R:C86	R:R:I37	3.27	No	Yes	0	5	6
4	R:R:I37	R:R:V266	6.14	Yes	No	0	6	5
5	R:R:I37	R:R:S269	4.64	Yes	No	0	6	5
6	R:R:I40	R:R:S269	3.1	No	No	0	7	5
7	R:R:I40	R:R:L270	4.28	No	No	0	7	6
8	R:R:A41	R:R:L79	4.73	No	Yes	0	5	7
9	R:R:G44	R:R:S273	3.71	No	No	0	9	8
10	R:R:F76	R:R:L45	4.87	Yes	No	0	7	7
11	R:R:L45	R:R:L79	4.15	No	Yes	0	7	7
12	R:R:D75	R:R:N48	6.73	No	Yes	1	9	9
13	R:R:F76	R:R:N48	3.62	Yes	Yes	0	7	9
14	R:R:N48	R:R:S272	4.47	Yes	No	1	9	9
15	R:R:N48	R:R:P276	13.03	Yes	No	0	9	9
16	R:R:G49	R:R:L52	5.13	No	No	0	6	8
17	R:R:F50	R:R:L54	4.87	No	No	0	5	8
18	R:R:F281	R:R:F50	4.29	No	No	0	6	5
19	R:R:A72	R:R:V51	3.39	No	No	0	9	9
20	R:R:F280	R:R:V51	5.24	Yes	No	0	8	9
21	R:R:G73	R:R:L52	3.42	No	No	0	5	8
22	R:R:F76	R:R:L52	4.87	Yes	No	0	7	8
23	R:R:L54	R:R:W53	5.69	No	No	0	8	6
24	R:R:F57	R:R:W53	4.01	No	No	0	5	6
25	R:R:F280	R:R:L54	4.87	Yes	No	0	8	8
26	R:R:L55	R:R:S65	6.01	Yes	No	0	8	8
27	R:R:L55	R:R:L69	8.3	Yes	No	0	8	7
28	R:R:F280	R:R:L55	7.31	Yes	Yes	0	8	8
29	R:R:F280	R:R:M59	4.98	Yes	No	0	8	6
30	R:R:R61	R:R:S65	3.95	No	No	0	7	8
31	R:R:A63	R:R:R141	4.15	No	Yes	0	7	8
32	R:R:A63	R:R:S146	3.42	No	Yes	0	7	9
33	R:R:F64	R:R:V68	5.24	No	No	0	7	8
34	R:R:F64	R:R:V123	3.93	No	No	5	7	9
35	R:R:F64	R:R:R127	5.34	No	No	5	7	9
36	R:R:S146	R:R:V66	8.08	Yes	No	0	9	6
37	R:R:T122	R:R:Y67	6.24	No	Yes	0	7	7
38	R:R:E126	R:R:Y67	6.73	No	Yes	0	9	7
39	R:R:S146	R:R:Y67	5.09	Yes	Yes	0	9	7
40	R:R:V149	R:R:Y67	3.79	No	Yes	0	6	7
41	R:R:M119	R:R:S70	7.67	Yes	No	1	6	9
42	R:R:C150	R:R:S70	3.44	No	No	1	7	9
43	R:R:S70	R:R:W154	6.18	No	No	0	9	9
44	R:R:L71	R:R:M119	5.65	No	Yes	1	9	6
45	R:R:L120	R:R:L71	4.15	Yes	No	1	9	9
46	R:R:L71	R:R:N275	8.24	No	Yes	1	9	9
47	R:R:D75	R:R:S272	11.78	No	No	1	9	9
48	R:R:D75	R:R:N275	10.77	No	Yes	1	9	9
49	R:R:C80	R:R:F76	4.19	No	Yes	0	4	7
50	R:R:F81	R:R:L77	3.65	No	No	0	5	6
51	R:R:A112	R:R:L77	4.73	No	No	0	7	6
52	R:R:F78	R:R:M109	6.22	Yes	No	0	6	4
53	R:R:F78	R:R:Y113	6.19	Yes	Yes	3	6	8
54	R:R:F239	R:R:F78	3.22	Yes	Yes	3	6	6
55	R:R:F78	R:R:S268	6.61	Yes	No	3	6	8
56	R:R:L79	R:R:S269	6.01	Yes	No	0	7	5
57	R:R:F81	R:R:V108	5.24	No	No	0	5	6
58	R:R:F81	R:R:M109	7.46	No	No	0	5	4
59	R:R:M109	R:R:Q82	4.08	No	No	0	4	5
60	R:R:Q82	R:R:V265	7.16	No	No	0	5	4
61	R:R:F105	R:R:I84	3.77	No	No	0	5	5
62	R:R:F101	R:R:N85	12.08	No	No	0	4	4
63	R:R:F101	R:R:V88	5.24	No	No	0	4	3
64	R:R:F93	R:R:L90	3.65	No	No	0	1	4
65	R:R:C95	R:R:I97	3.27	No	No	0	4	5
66	R:R:F105	R:R:P102	13	No	No	0	5	5
67	R:R:F170	R:R:S103	5.28	Yes	No	0	3	5
68	R:R:F104	R:R:F105	5.36	No	No	0	4	5
69	R:R:F104	R:R:V108	3.93	No	No	0	4	6
70	R:R:F104	R:R:L171	3.65	No	No	0	4	1
71	R:R:F170	R:R:T106	7.78	Yes	No	0	3	5
72	R:R:L171	R:R:T107	4.42	No	No	0	1	4
73	R:R:S161	R:R:T110	6.4	No	No	0	7	2
74	R:R:E164	R:R:T110	5.64	Yes	No	2	4	2
75	R:R:F244	R:R:T110	3.89	Yes	No	2	5	2
76	R:R:C111	R:R:L158	6.35	No	No	0	5	4
77	R:R:C111	R:R:S161	3.44	No	No	0	5	7
78	R:R:L114	R:R:Y113	3.52	No	Yes	0	6	8
79	R:R:L117	R:R:Y113	7.03	No	Yes	0	8	8
80	R:R:F239	R:R:Y113	15.47	Yes	Yes	3	6	8
81	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
82	R:R:L114	R:R:L191	4.15	No	No	0	6	7
83	R:R:A115	R:R:W154	10.37	No	No	0	7	9
84	R:R:A115	R:R:S157	3.42	No	No	0	7	8
85	R:R:F232	R:R:L117	7.31	Yes	No	0	9	8
86	R:R:G236	R:R:L117	5.13	No	No	0	7	8
87	R:R:L153	R:R:S118	6.01	No	No	0	7	8
88	R:R:C150	R:R:M119	3.24	No	Yes	1	7	6
89	R:R:L153	R:R:M119	4.24	No	Yes	0	7	6
90	R:R:F232	R:R:L120	6.09	Yes	Yes	0	9	9
91	R:R:L120	R:R:N275	8.24	Yes	Yes	1	9	9
92	R:R:L120	R:R:Y279	8.21	Yes	Yes	0	9	9
93	R:R:L194	R:R:S121	4.5	No	No	0	8	7
94	R:R:S121	R:R:V197	3.23	No	No	0	7	6
95	R:R:R127	R:R:V123	6.54	No	No	5	9	9
96	R:R:V123	R:R:Y279	7.57	No	Yes	0	9	9
97	R:R:L198	R:R:S124	6.01	No	No	0	8	9
98	R:R:S124	R:R:S202	3.26	No	No	0	9	8
99	R:R:S201	R:R:T125	6.4	No	No	0	8	7
100	R:R:E126	R:R:Y137	3.37	No	Yes	4	9	7
101	R:R:E126	R:R:R141	8.14	No	Yes	4	9	8
102	R:R:C128	R:R:S201	6.89	No	No	0	8	8
103	R:R:L129	R:R:W136	3.42	No	No	0	6	6
104	R:R:S130	R:R:V131	3.23	No	No	0	8	8
105	R:R:S130	R:R:Y137	8.9	No	Yes	0	8	7
106	R:R:L205	R:R:V131	4.47	No	No	0	8	8
107	R:R:L132	R:R:W133	15.94	No	No	0	6	5
108	R:R:L132	R:R:R208	8.5	No	No	0	6	7
109	R:R:W136	R:R:Y137	5.79	No	Yes	0	6	7
110	R:R:R140	R:R:W136	14.99	No	No	0	6	6
111	R:R:R141	R:R:Y137	12.35	Yes	Yes	4	8	7
112	R:R:L145	R:R:R141	4.86	No	Yes	0	5	8
113	R:R:L145	R:R:P142	6.57	No	No	0	5	7
114	R:R:H144	R:R:R143	6.77	No	No	0	5	5
115	R:R:L156	R:R:W190	4.56	No	Yes	0	6	7
116	R:R:L160	R:R:T187	5.9	No	No	0	4	4
117	R:R:F183	R:R:L163	9.74	No	No	0	4	8
118	R:R:C168	R:R:E164	4.56	No	Yes	0	6	4
119	R:R:D184	R:R:E164	6.5	No	Yes	2	3	4
120	R:R:E164	R:R:W243	4.36	Yes	Yes	2	4	4
121	R:R:E164	R:R:F244	9.33	Yes	Yes	2	4	5
122	R:R:F167	R:R:W179	7.02	No	No	0	4	2
123	R:R:F167	R:R:F183	5.36	No	No	0	4	4
124	R:R:C168	R:R:C180	7.28	No	No	0	6	9
125	R:R:T182	R:R:W179	8.49	No	No	0	2	2
126	R:R:C180	R:R:D184	4.67	No	No	0	9	3
127	R:R:C180	R:R:W248	3.92	No	No	0	9	3
128	R:R:F185	R:R:Q181	7.03	No	No	0	3	3
129	R:R:Q181	R:R:W248	5.48	No	No	0	3	3
130	R:R:D184	R:R:F244	15.52	No	Yes	2	3	5
131	R:R:F185	R:R:L245	3.65	No	No	0	3	5
132	R:R:F244	R:R:T187	9.08	Yes	No	0	5	4
133	R:R:L194	R:R:W190	14.81	No	Yes	0	8	7
134	R:R:F193	R:R:V197	6.55	No	No	0	5	6
135	R:R:C199	R:R:F195	8.38	No	Yes	0	5	6
136	R:R:F195	R:R:F232	7.5	Yes	Yes	0	6	9
137	R:R:F195	R:R:L233	7.31	Yes	No	0	6	7
138	R:R:F195	R:R:L237	4.87	Yes	No	0	6	6
139	R:R:F232	R:R:L198	7.31	Yes	No	0	9	8
140	R:R:I225	R:R:S202	3.1	No	No	0	7	8
141	R:R:S202	R:R:V229	3.23	No	No	0	8	8
142	R:R:I225	R:R:L205	4.28	No	No	0	7	8
143	R:R:L206	R:R:Y222	7.03	No	No	0	5	6
144	R:R:I209	R:R:L221	7.14	No	No	0	6	8
145	R:R:L216	R:R:S213	6.01	No	No	0	4	7
146	R:R:L218	R:R:S213	4.5	No	No	0	7	7
147	R:R:L216	R:R:P217	3.28	No	No	0	4	5
148	R:R:L216	R:R:L221	4.15	No	No	0	4	8
149	R:R:I225	R:R:L221	4.28	No	No	0	7	8
150	R:R:L226	R:R:Y222	3.52	No	No	0	5	6
151	R:R:T228	R:R:Y279	4.99	No	Yes	0	7	9
152	R:R:C235	R:R:L270	3.17	No	No	0	7	6
153	R:R:C235	R:R:N271	4.72	No	No	0	7	9
154	R:R:G236	R:R:N271	5.09	No	No	0	7	9
155	R:R:L267	R:R:P238	3.28	No	No	0	7	9
156	R:R:F239	R:R:S264	3.96	Yes	No	0	6	5
157	R:R:F239	R:R:V265	6.55	Yes	No	0	6	4
158	R:R:F239	R:R:S268	7.93	Yes	No	3	6	8
159	R:R:H261	R:R:Q242	13.6	No	No	0	2	1
160	R:R:Q242	R:R:S264	10.11	No	No	0	1	5
161	R:R:F244	R:R:W243	9.02	Yes	Yes	2	5	4
162	R:R:H261	R:R:W243	3.17	No	Yes	0	2	4
163	R:R:I246	R:R:W250	5.87	No	No	0	4	1
164	R:R:F257	R:R:L247	12.18	No	No	0	3	3
165	R:R:D252	R:R:W250	18.98	No	No	6	1	1
166	R:R:L256	R:R:W250	3.42	No	No	6	2	1
167	R:R:D252	R:R:L256	14.93	No	No	6	1	2
168	R:R:C258	R:R:D254	3.11	No	No	0	1	1
169	R:R:C258	R:R:F257	4.19	No	No	0	1	3
170	R:R:N271	R:R:N275	5.45	No	Yes	0	9	9
171	R:R:N275	R:R:P276	4.89	Yes	No	0	9	9
172	R:R:I278	R:R:Y279	4.84	No	Yes	0	8	9
173	R:R:F280	R:R:F281	5.36	Yes	No	0	8	6
174	R:R:F280	R:R:S284	6.61	Yes	No	0	8	7
175	R:R:F170	R:R:W243	3.01	Yes	Yes	0	3	4
176	R:R:L55	R:R:V68	2.98	Yes	No	0	8	8
177	R:R:N92	R:R:S91	2.98	No	No	0	3	2
178	R:R:I241	R:R:I246	2.94	No	No	0	6	4
179	R:R:I162	R:R:L158	2.85	No	No	0	4	4
180	R:R:I278	R:R:L227	2.85	No	No	0	8	7
181	R:R:L206	R:R:L210	2.77	No	No	0	5	5
182	R:R:L210	R:R:L218	2.77	No	No	0	5	7
183	R:R:L226	R:R:L230	2.77	No	No	0	5	5
184	R:R:L233	R:R:L234	2.77	No	No	0	7	5
185	R:R:I260	R:R:Q242	2.74	No	No	0	3	1
186	R:R:A74	R:R:W154	2.59	No	No	0	9	9
187	R:R:I135	R:R:R140	2.51	No	No	0	6	6
188	R:R:F193	R:R:M196	2.49	No	No	0	5	5
189	R:R:M59	R:R:R58	2.48	No	No	0	6	5
190	R:R:L129	R:R:W133	2.28	No	No	0	6	5
191	R:R:L153	R:R:W190	2.28	No	Yes	0	7	7
192	R:R:L160	R:R:W190	2.28	No	Yes	0	4	7
193	R:R:L247	R:R:W243	2.28	No	Yes	0	3	4
194	R:R:G169	R:R:G175	2.11	No	No	0	1	3
195	R:R:G47	R:R:P276	2.03	No	No	0	8	9
196	R:R:G236	R:R:P238	2.03	No	No	0	7	9
197	R:R:C211	R:R:G212	1.96	No	No	0	5	5
198	R:R:A74	R:R:G116	1.95	No	No	0	9	9
199	R:R:G283	R:R:S284	1.86	No	No	0	9	7
200	R:R:G165	R:R:T107	1.82	No	No	0	3	4
201	R:R:A204	R:R:C128	1.81	No	No	0	6	8
202	R:R:C86	R:R:V34	1.71	No	No	0	5	4
203	R:R:G44	R:R:L79	1.71	No	Yes	0	9	7
204	R:R:A147	R:R:S146	1.71	No	Yes	0	5	9
205	R:R:G200	R:R:L203	1.71	No	No	0	4	5
206	R:R:C235	R:R:V231	1.71	No	No	0	7	7
207	R:R:A274	R:R:V231	1.7	No	No	0	7	7
208	R:R:D176	R:R:G178	1.68	No	No	0	3	3
209	R:R:S96	R:R:S98	1.63	No	No	0	5	6
210	R:R:A41	R:R:I83	1.62	No	No	0	5	6
211	R:R:S273	R:R:V43	1.62	No	No	0	8	5
212	R:R:S91	R:R:V88	1.62	No	No	0	2	3
213	R:R:S201	R:R:V197	1.62	No	No	0	8	6
214	R:R:V148	R:R:V149	1.6	No	No	0	4	6
215	R:R:A188	R:R:L245	1.58	No	No	0	5	5
216	R:R:I277	R:R:S273	1.55	No	No	0	6	8
217	R:R:I186	R:R:T182	1.52	No	No	0	6	2
218	R:R:F57	R:R:G56	1.51	No	No	0	5	6
219	R:R:F170	R:R:G169	1.51	Yes	No	0	3	1
220	R:R:G215	R:R:R214	1.5	No	No	0	5	5
221	R:R:L36	R:R:V266	1.49	No	No	0	5	5
222	R:R:N92	R:R:S98	1.49	No	No	0	3	6
223	R:R:L203	R:R:V207	1.49	No	No	0	5	5
224	R:R:F101	R:R:P102	1.44	No	No	0	4	5
225	R:R:I83	R:R:L38	1.43	No	No	0	6	5
226	R:R:I162	R:R:L163	1.43	No	No	0	4	8
227	R:R:I241	R:R:L237	1.43	No	No	0	6	6
228	R:R:L38	R:R:L90	1.38	No	No	0	5	4
229	R:R:L159	R:R:L163	1.38	No	No	0	4	8
230	R:R:N100	R:R:N92	1.36	No	No	0	1	3
231	R:R:P134	R:R:W133	1.35	No	No	0	9	5
232	R:R:R220	R:R:V282	1.31	No	No	0	8	7
233	R:R:V34	R:R:Y89	1.26	No	No	0	4	2
234	R:R:F167	R:R:K166	1.24	No	No	0	4	3
235	R:R:F35	R:R:L90	1.22	No	No	0	4	4
236	R:R:F39	R:R:L38	1.22	No	No	0	5	5
237	R:R:D176	R:R:W179	1.12	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I37	6.2575	4	0	6
2	R:R:N48	6.9625	4	1	9
3	R:R:L55	6.15	4	0	8
4	R:R:Y67	5.4625	4	0	7
5	R:R:F76	4.3875	4	0	7
6	R:R:F78	5.56	4	3	6
7	R:R:L79	4.15	4	0	7
8	R:R:Y113	7.312	5	3	8
9	R:R:M119	5.2	4	1	6
10	R:R:L120	6.6725	4	1	9
11	R:R:Y137	7.6025	4	4	7
12	R:R:R141	7.375	4	4	8
13	R:R:S146	4.575	4	0	9
14	R:R:E164	6.078	5	2	4
15	R:R:F170	4.395	4	0	3
16	R:R:W190	5.9825	4	0	7
17	R:R:F195	7.015	4	0	6
18	R:R:F232	7.0525	4	0	9
19	R:R:F239	7.426	5	3	6
20	R:R:W243	4.368	5	2	4
21	R:R:F244	9.368	5	2	5
22	R:R:N275	7.518	5	1	9
23	R:R:Y279	6.4025	4	0	9
24	R:R:F280	5.72833	6	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C86	R:R:I37	12.4775	3.27	No	Yes	0	5	6
2	R:R:I37	R:R:Q82	34.9279	10.98	Yes	No	0	6	5
3	R:R:I37	R:R:S269	23.2252	4.64	Yes	No	0	6	5
4	R:R:A41	R:R:L79	21.8198	4.73	No	Yes	0	5	7
5	R:R:L79	R:R:S269	17.1261	6.01	Yes	No	0	7	5
6	R:R:G44	R:R:L79	12.7117	1.71	No	Yes	0	9	7
7	R:R:F76	R:R:L45	29.3333	4.87	Yes	No	0	7	7
8	R:R:L45	R:R:L79	27.9459	4.15	No	Yes	0	7	7
9	R:R:D75	R:R:N48	21.5495	6.73	No	Yes	1	9	9
10	R:R:F76	R:R:N48	41.027	3.62	Yes	Yes	0	7	9
11	R:R:N48	R:R:P276	21.8198	13.03	Yes	No	0	9	9
12	R:R:F76	R:R:L52	10.3514	4.87	Yes	No	0	7	8
13	R:R:F280	R:R:L54	11.5586	4.87	Yes	No	0	8	8
14	R:R:F280	R:R:L55	31.3964	7.31	Yes	Yes	0	8	8
15	R:R:L55	R:R:V68	39.5045	2.98	Yes	No	0	8	8
16	R:R:F64	R:R:V68	41.5405	5.24	No	No	0	7	8
17	R:R:F64	R:R:V123	43.3784	3.93	No	No	5	7	9
18	R:R:V123	R:R:Y279	47.3333	7.57	No	Yes	0	9	9
19	R:R:L120	R:R:Y279	54.991	8.21	Yes	Yes	0	9	9
20	R:R:F232	R:R:L120	84.0901	6.09	Yes	Yes	0	9	9
21	R:R:F232	R:R:L117	84.2342	7.31	Yes	No	0	9	8
22	R:R:L117	R:R:Y113	85.7748	7.03	No	Yes	0	8	8
23	R:R:F78	R:R:Y113	32.3153	6.19	Yes	Yes	3	6	8
24	R:R:F78	R:R:M109	43.3874	6.22	Yes	No	0	6	4
25	R:R:M109	R:R:Q82	14.3604	4.08	No	No	0	4	5
26	R:R:F239	R:R:Y113	53.1622	15.47	Yes	Yes	3	6	8
27	R:R:F239	R:R:V265	24.8108	6.55	Yes	No	0	6	4
28	R:R:Q82	R:R:V265	23.3874	7.16	No	No	0	5	4
29	R:R:L120	R:R:N275	40.964	8.24	Yes	Yes	1	9	9
30	R:R:N271	R:R:N275	15.7297	5.45	No	Yes	0	9	9
31	R:R:C235	R:R:N271	15.7027	4.72	No	No	0	7	9
32	R:R:C235	R:R:L270	10.1351	3.17	No	No	0	7	6
33	R:R:A63	R:R:R141	10.2973	4.15	No	Yes	0	7	8
34	R:R:R141	R:R:Y137	17.8018	12.35	Yes	Yes	4	8	7
35	R:R:S130	R:R:Y137	59.9459	8.9	No	Yes	0	8	7
36	R:R:S130	R:R:V131	62.2342	3.23	No	No	0	8	8
37	R:R:L205	R:R:V131	64.3694	4.47	No	No	0	8	8
38	R:R:I225	R:R:L205	66.6396	4.28	No	No	0	7	8
39	R:R:I225	R:R:S202	91.964	3.1	No	No	0	7	8
40	R:R:S124	R:R:S202	96.0541	3.26	No	No	0	9	8
41	R:R:L198	R:R:S124	98.036	6.01	No	No	0	8	9
42	R:R:F232	R:R:L198	100	7.31	Yes	No	0	9	8
43	R:R:E126	R:R:Y137	20.7027	3.37	No	Yes	4	9	7
44	R:R:E126	R:R:Y67	18.2613	6.73	No	Yes	0	9	7
45	R:R:L71	R:R:M119	62.3964	5.65	No	Yes	1	9	6
46	R:R:L71	R:R:N275	19.7117	8.24	No	Yes	1	9	9
47	R:R:M119	R:R:S70	12.4775	7.67	Yes	No	1	6	9
48	R:R:S70	R:R:W154	10.4865	6.18	No	No	0	9	9
49	R:R:F81	R:R:M109	39.5495	7.46	No	No	0	5	4
50	R:R:F81	R:R:V108	33.6577	5.24	No	No	0	5	6
51	R:R:F104	R:R:F105	23.5225	5.36	No	No	0	4	5
52	R:R:F104	R:R:V108	31.6667	3.93	No	No	0	4	6
53	R:R:F101	R:R:P102	17.2162	1.44	No	No	0	4	5
54	R:R:F105	R:R:P102	19.3333	13	No	No	0	5	5
55	R:R:I83	R:R:L38	15.6036	1.43	No	No	0	6	5
56	R:R:A41	R:R:I83	18.7207	1.62	No	No	0	5	6
57	R:R:F170	R:R:W243	12.2613	3.01	Yes	Yes	0	3	4
58	R:R:H261	R:R:W243	69.0631	3.17	No	Yes	0	2	4
59	R:R:H261	R:R:Q242	69.6757	13.6	No	No	0	2	1
60	R:R:Q242	R:R:S264	71.0541	10.11	No	No	0	1	5
61	R:R:F239	R:R:S264	71.955	3.96	Yes	No	0	6	5
62	R:R:E164	R:R:W243	33.009	4.36	Yes	Yes	2	4	4
63	R:R:E164	R:R:T110	18.5495	5.64	Yes	No	2	4	2
64	R:R:S161	R:R:T110	50.3063	6.4	No	No	0	7	2
65	R:R:F244	R:R:W243	33.3153	9.02	Yes	Yes	2	5	4
66	R:R:F244	R:R:T110	35.045	3.89	Yes	No	2	5	2
67	R:R:C111	R:R:S161	46.8288	3.44	No	No	0	5	7
68	R:R:C111	R:R:L158	43.3333	6.35	No	No	0	5	4
69	R:R:G236	R:R:L117	12.955	5.13	No	No	0	7	8
70	R:R:G236	R:R:N271	10.3063	5.09	No	No	0	7	9
71	R:R:L153	R:R:M119	53.4595	4.24	No	Yes	0	7	6
72	R:R:L194	R:R:W190	18.7207	14.81	No	Yes	0	8	7
73	R:R:L153	R:R:W190	51.045	2.28	No	Yes	0	7	7
74	R:R:L194	R:R:S121	16.7117	4.5	No	No	0	8	7
75	R:R:S121	R:R:V197	14.6847	3.23	No	No	0	7	6
76	R:R:L129	R:R:W136	13.3784	3.42	No	No	0	6	6
77	R:R:W136	R:R:Y137	21.2162	5.79	No	Yes	0	6	7
78	R:R:L129	R:R:W133	10.7297	2.28	No	No	0	6	5
79	R:R:L160	R:R:T187	36.5225	5.9	No	No	0	4	4
80	R:R:F244	R:R:T187	35.9189	9.08	Yes	No	0	5	4
81	R:R:F183	R:R:L163	29.1622	9.74	No	No	0	4	8
82	R:R:I162	R:R:L163	36.2883	1.43	No	No	0	4	8
83	R:R:I162	R:R:L158	39.8198	2.85	No	No	0	4	4
84	R:R:D184	R:R:F244	16.8919	15.52	No	Yes	2	3	5
85	R:R:F167	R:R:F183	25.5856	5.36	No	No	0	4	4
86	R:R:F167	R:R:W179	18.3694	7.02	No	No	0	4	2
87	R:R:C180	R:R:D184	22.036	4.67	No	No	0	9	3
88	R:R:C180	R:R:W248	24.6757	3.92	No	No	0	9	3
89	R:R:F185	R:R:Q181	14.8829	7.03	No	No	0	3	3
90	R:R:Q181	R:R:W248	19.8018	5.48	No	No	0	3	3
91	R:R:F195	R:R:F232	26.2162	7.5	Yes	Yes	0	6	9
92	R:R:F195	R:R:L237	15.8739	4.87	Yes	No	0	6	6
93	R:R:L206	R:R:L210	10.7568	2.77	No	No	0	5	5
94	R:R:L210	R:R:L218	13.3964	2.77	No	No	0	5	7
95	R:R:L218	R:R:S213	16.036	4.5	No	No	0	7	7
96	R:R:L216	R:R:S213	18.6577	6.01	No	No	0	4	7
97	R:R:L216	R:R:L221	23.8288	4.15	No	No	0	4	8
98	R:R:I225	R:R:L221	28.7477	4.28	No	No	0	7	8
99	R:R:I241	R:R:I246	10.5946	2.94	No	No	0	6	4
100	R:R:I241	R:R:L237	13.2432	1.43	No	No	0	6	6
101	R:R:S91	R:R:V88	11.1081	1.62	No	No	0	2	3
102	R:R:F101	R:R:V88	13.0991	5.24	No	No	0	4	3
103	R:R:L120	R:R:L71	43.7387	4.15	Yes	No	1	9	9
104	R:R:L160	R:R:W190	37.2613	2.28	No	Yes	0	4	7
105	R:R:D75	R:R:N275	25.2252	10.77	No	Yes	1	9	9
106	R:R:N275	R:R:P276	25.2252	4.89	Yes	No	0	9	9
107	R:R:F239	R:R:F78	13.0901	3.22	Yes	Yes	3	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7VUZ_nogp

PDB Summary
PDB	7VUZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	224
Number of Links	237
Number of Hubs	24
Number of Links mediated by Hubs	89
Number of Communities	6
Number of Nodes involved in Communities	27
Number of Links involved in Communities	32

Path Summary
Number Of Nodes in MetaPath	108
Number Of Links MetaPath	107
Number of Shortest Paths	32205
Length Of Smallest Path	3
Average Path Length	14.864
Length of Longest Path	33
Minimum Path Strength	1.27333
Average Path Strength	5.76057
Maximum Path Strength	12.425
Minimum Path Correlation	0.7
Average Path Correlation	0.926252
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	48.2598
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.4258
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • sleep • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cellular process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • establishment of organelle localization • regulated exocytosis • cellular localization • response to stimulus • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • system process • sensory perception • nervous system process • sensory perception of pain • cellular anatomical structure • membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cellular component organization or biogenesis • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7VUZ_nogp_Chain_R V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G S R G L P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W K D S D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	10.1038/s41586-021-04077-y
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VUZ_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.