Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 4.92585
2A:A:K46 4.665409
3A:A:M53 5.06754218
4A:A:F191 7.2175485
5A:A:L194 3.99684
6A:A:F196 8.78587
7A:A:K197 7.545416
8A:A:F199 8.65515
9A:A:Q204 5.54333619
10A:A:S206 5.375418
11A:A:K209 4.982518
12A:A:K210 7.0775419
13A:A:W211 5.37167619
14A:A:H213 5.485418
15A:A:I221 3.8654118
16A:A:F223 7.2285119
17A:A:V225 5.385407
18A:A:D229 7.0725498
19A:A:Y230 6.29333698
20A:A:F250 6.984297119
21A:A:W258 7.17167615
22A:A:F259 5.66254119
23A:A:I264 4.23754116
24A:A:L268 5.75754228
25A:A:C286 4.2375406
26A:A:Y287 4.4356137
27A:A:Y290 7.646137
28A:A:Y296 13.23754244
29A:A:T316 5.224233
30A:A:I319 6.554115
31A:A:Y320 9.0825197
32A:A:T321 6.825405
33A:A:F323 4.89754224
34A:A:C325 5.185407
35A:A:Q333 4.37485
36A:A:F336 5.215488
37A:A:I343 5.33407
38A:A:N347 6.0075458
39A:A:L348 4.205459
40A:A:L353 5.545457
41B:B:L14 3.135408
42B:B:L30 6.49405
43B:B:H54 6.965629
44B:B:K57 12.265419
45B:B:I58 4.715429
46B:B:Y59 8.2675418
47B:B:M61 4.13426
48B:B:W63 5.37714727
49B:B:L70 5.2275425
50B:B:Q75 7.8975419
51B:B:D76 5.614529
52B:B:L79 5.55477
53B:B:I80 6.896528
54B:B:I81 5.43577
55B:B:W82 10.78629
56B:B:D83 8.1975428
57B:B:S84 4.08425
58B:B:Y85 13.1975424
59B:B:N88 5.562527
60B:B:K89 7.03833629
61B:B:I93 6.93577
62B:B:L95 4.365478
63B:B:W99 7.075619
64B:B:Y105 5.01667676
65B:B:N110 6.1325414
66B:B:Y111 7.06514
67B:B:V112 4.838578
68B:B:C114 3.418578
69B:B:L117 5.186519
70B:B:N119 4.925419
71B:B:I123 4.10833616
72B:B:Y124 4.65143776
73B:B:L126 4.835475
74B:B:V133 6.15474
75B:B:H142 6.96857719
76B:B:Y145 5.15778918
77B:B:F151 5.162519
78B:B:Q156 5.605405
79B:B:I157 4.162517
80B:B:T159 4.896519
81B:B:S161 8.095419
82B:B:D163 7.896519
83B:B:C166 4.235448
84B:B:L168 4.614546
85B:B:W169 7.65714718
86B:B:F180 7.946547
87B:B:H183 7.81143749
88B:B:D186 4.13667619
89B:B:V187 5.256549
90B:B:L190 4.3675445
91B:B:F199 7.304549
92B:B:V200 6.8675436
93B:B:S201 4.875449
94B:B:D205 7.4075449
95B:B:S207 5.1375445
96B:B:K209 8.10333646
97B:B:L210 6.92405
98B:B:W211 8.87648
99B:B:Q220 8.685437
100B:B:F222 6.776538
101B:B:H225 9.81167639
102B:B:D228 6.92519
103B:B:I232 7.005438
104B:B:F234 3.51735
105B:B:F235 6.321676126
106B:B:N237 8.01754125
107B:B:F241 7.06429736
108B:B:T243 6.0625408
109B:B:D246 7.8475419
110B:B:D247 6.7539
111B:B:T249 5.365436
112B:B:R251 10.5867638
113B:B:L252 4.69754257
114B:B:F253 6.76333636
115B:B:D258 9.678537
116B:B:M262 6.99754254
117B:B:Y264 5.3725255
118B:B:F278 9.305407
119B:B:R283 8.59754149
120B:B:Y289 6.518577167
121B:B:D290 8.475406
122B:B:N295 7.79254166
123B:B:D298 8.10754149
124B:B:K301 6.864145
125B:B:H311 9.324109
126B:B:T329 5.37754108
127B:B:W332 12.47619
128B:B:D333 9.14754109
129B:B:L336 5.2875427
130B:B:K337 6.144106
131B:B:I338 4.32425
132B:B:W339 9.458336109
133G:G:R27 5.605408
134G:G:D36 4.984125
135G:G:Y40 6.82754126
136G:G:L51 7.374146
137G:G:F61 5.07667628
138R:R:I37 6.2575406
139R:R:N48 6.9625469
140R:R:L55 5.5165158
141R:R:F64 4.7575457
142R:R:Y67 5.4625407
143R:R:F76 4.112567
144R:R:F78 5.564176
145R:R:L79 3.92507
146R:R:Y113 7.3125178
147R:R:M119 4.762566
148R:R:L120 6.6725469
149R:R:R127 6.7475459
150R:R:S130 5.01458
151R:R:V131 3.4375408
152R:R:W136 6.8456
153R:R:Y137 8.06667657
154R:R:R141 6.5558
155R:R:S146 4.575409
156R:R:L153 3.87467
157R:R:E164 6.0785184
158R:R:F170 4.395403
159R:R:W190 5.388507
160R:R:F195 7.015406
161R:R:R214 10.29254195
162R:R:L216 4.3975454
163R:R:L221 5.052558
164R:R:F232 7.0525409
165R:R:F239 6.696176
166R:R:W243 4.3685184
167R:R:F244 9.3685185
168R:R:N275 7.518569
169R:R:Y279 6.4025409
170R:R:F280 5.728336158
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:H54 10.593.78YesYes299
2B:B:A56 B:B:D76 15.39693.09NoYes079
3B:B:A56 B:B:Q75 15.71693.03NoYes079
4B:B:Q75 B:B:W99 17.19913.29YesYes199
5A:A:F223 A:A:I253 36.0885.02YesNo098
6A:A:F223 A:A:G40 1003.01YesNo099
7A:A:G40 A:A:K46 99.8683.49NoYes099
8A:A:K46 A:A:L38 97.43725.64YesNo098
9A:A:L38 A:A:M198 96.60434.24NoNo087
10A:A:F189 A:A:M198 96.18373.73NoNo097
11A:A:F189 A:A:F196 93.976516.08NoYes097
12B:B:L117 B:B:W99 12.27935.69YesYes199
13A:A:R208 A:A:W211 72.37846NoYes099
14A:A:L249 A:A:R208 72.23014.86NoNo099
15A:A:F223 A:A:L249 72.17547.31YesNo099
16A:A:F196 A:A:L194 92.96918.53YesYes874
17A:A:F223 A:A:F250 31.987817.15YesYes1199
18A:A:F250 A:A:F307 28.99716.43YesNo098
19A:A:F307 A:A:V225 12.11619.18NoYes087
20A:A:M243 A:A:V225 10.81073.04NoYes087
21A:A:C286 A:A:M243 10.51033.24YesNo068
22A:A:C286 A:A:Y230 25.10585.38YesYes068
23A:A:K277 A:A:Y230 22.46933.58NoYes998
24A:A:K277 A:A:L232 21.35185.64NoNo998
25A:A:F307 A:A:M247 16.64974.98NoNo086
26A:A:M247 A:A:Y287 32.68665.99NoYes067
27A:A:C286 A:A:Y287 21.10645.38YesYes067
28A:A:F250 A:A:L310 17.85133.65YesNo094
29A:A:L310 A:A:M247 16.65547.07NoNo046
30A:A:L266 A:A:T321 10.25237.37NoYes095
31A:A:D229 A:A:L232 17.9839.5YesNo988
32A:A:D229 A:A:S228 15.74397.36YesNo089
33B:B:S84 G:G:F61 17.56845.28YesYes258
34B:B:M61 B:B:W63 23.89345.82YesYes267
35B:B:C317 B:B:M61 35.79553.24NoYes076
36B:B:C317 B:B:S316 36.24563.44NoNo079
37B:B:S316 B:B:W332 36.70167.41NoYes099
38A:A:H213 B:B:W332 23.34885.29YesYes189
39A:A:H213 A:A:K209 15.12885.24YesYes188
40B:B:L70 B:B:M61 10.97154.24YesYes256
41A:A:K209 A:A:K210 18.5555.75YesYes189
42A:A:K210 B:B:Y145 47.98335.97YesYes198
43A:A:I212 A:A:K209 18.73352.91NoYes088
44B:B:R314 B:B:W332 15.838623.99NoYes089
45A:A:W258 B:B:R314 26.69984YesNo058
46B:B:C148 B:B:L190 10.32856.35NoYes065
47B:B:L190 B:B:S160 11.96613YesNo056
48B:B:S147 B:B:S160 16.69244.89NoNo096
49B:B:M188 B:B:S147 16.90044.6NoNo089
50B:B:M188 B:B:Y145 15.50713.59NoYes088
51A:A:K210 B:B:D246 56.72285.53YesYes199
52A:A:F259 A:A:I212 18.67915.02YesNo098
53A:A:N256 A:A:W258 31.57944.52NoYes085
54A:A:F259 A:A:N256 31.51444.83YesNo098
55A:A:F259 A:A:I221 49.92035.02YesYes1198
56A:A:I221 A:A:I253 28.28582.94YesNo088
57A:A:I221 A:A:I264 21.94822.94YesYes1186
58A:A:I343 A:A:L194 92.41842.85YesYes074
59A:A:I343 A:A:N347 91.66984.25YesYes078
60A:A:N347 R:R:S130 33.93734.47YesYes588
61A:A:N347 R:R:Y137 57.430613.96YesYes587
62A:A:C351 R:R:S130 28.10343.44NoYes548
63A:A:C351 R:R:R127 56.01374.18NoYes549
64A:A:C351 R:R:Y137 28.33584.03NoYes547
65B:B:D258 B:B:R22 17.90398.34YesNo076
66B:B:I18 B:B:R22 17.33113.76NoNo076
67B:B:I18 G:G:A23 33.51123.25NoNo078
68B:B:L14 G:G:A23 32.36011.58YesNo088
69B:B:L14 G:G:L19 18.52184.15YesNo089
70B:B:A11 G:G:L19 16.2111.58NoNo059
71B:B:A11 G:G:V16 13.89891.7NoNo057
72B:B:L7 G:G:V16 12.74244.47NoNo087
73B:B:L7 G:G:A12 10.42841.58NoNo085
74B:B:D258 G:G:E22 17.90393.9YesNo079
75B:B:I18 G:G:E22 17.33114.1NoNo079
76B:B:L14 B:B:Q17 11.58553.99YesNo084
77B:B:D290 B:B:R314 25.006621.44YesNo068
78B:B:C271 B:B:D290 24.09996.22NoYes056
79B:B:C271 B:B:D291 23.7414.67NoNo058
80B:B:D291 B:B:Y289 22.77313.45NoYes087
81B:B:I273 B:B:Y289 11.67578.46NoYes067
82B:B:G288 B:B:Y289 13.56532.9NoYes077
83B:B:G288 B:B:V315 13.31753.68NoNo077
84B:B:C294 B:B:V315 10.50935.12NoNo057
85B:B:N340 G:G:F61 11.79093.62NoYes098
86B:B:H142 B:B:W169 23.08673.17YesYes198
87B:B:I157 B:B:W169 14.12893.52YesYes178
88B:B:G162 B:B:Y145 17.17595.79NoYes198
89B:B:G162 B:B:S161 19.41583.71NoYes199
90B:B:H142 B:B:S161 17.6815.34YesYes199
91B:B:D246 B:B:S227 57.44664.42YesNo096
92B:B:D247 B:B:S227 57.32915.89YesNo096
93B:B:D247 B:B:H225 20.4263.78YesYes399
94B:B:H225 B:B:R251 17.973324.83YesYes398
95B:B:F253 B:B:R251 52.22738.55YesYes368
96B:B:D247 B:B:E226 18.10387.8YesNo093
97B:B:E226 B:B:R251 17.947410.47NoYes038
98B:B:D247 B:B:T249 18.49178.67YesYes396
99B:B:R251 B:B:T249 17.98583.88YesYes386
100R:R:R127 R:R:V123 45.79866.54YesNo599
101R:R:V123 R:R:Y279 45.96977.57NoYes099
102R:R:L120 R:R:Y279 44.29828.21YesYes099
103R:R:L120 R:R:N275 21.99248.24YesYes699
104R:R:D75 R:R:N275 20.345210.77NoYes699
105R:R:D75 R:R:S272 14.886711.78NoNo699
106R:R:L79 R:R:S272 14.23553YesNo079
107R:R:E126 R:R:Y137 26.72583.37NoYes597
108R:R:E126 R:R:Y67 26.71266.73NoYes097
109R:R:T122 R:R:Y67 25.53536.24NoYes077
110R:R:M119 R:R:T122 13.40643.01YesNo667
111R:R:L71 R:R:M119 12.02175.65NoYes696
112R:R:L71 R:R:N275 11.20098.24NoYes699
113R:R:F232 R:R:L120 22.17446.09YesYes099
114R:R:F232 R:R:L117 17.70967.31YesNo098
115R:R:L117 R:R:Y113 16.0227.03NoYes088
116R:R:F78 R:R:Y113 10.62436.19YesYes1768
117R:R:L153 R:R:T122 11.92992.95YesNo677
118R:R:L153 R:R:W190 12.22022.28YesYes077
119B:B:F241 B:B:F253 15.09759.65YesYes366
120B:B:F222 B:B:F253 39.28679.65YesYes386
121B:B:D258 B:B:F222 36.8974.78YesYes378
122B:B:F234 B:B:F241 12.65544.29YesYes356
123A:A:W211 B:B:Y145 56.64533.86YesYes198
124A:A:F250 A:A:I264 19.68073.77YesYes1196
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7VUZ
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRX2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.89
Date 2021-12-01
D.O.I. 10.1038/s41586-021-04077-y
Net Summary
Imin 2.9
Number of Linked Nodes 818
Number of Links 1021
Number of Hubs 170
Number of Links mediated by Hubs 613
Number of Communities 27
Number of Nodes involved in Communities 255
Number of Links involved in Communities 376
Path Summary
Number Of Nodes in MetaPath 125
Number Of Links MetaPath 124
Number of Shortest Paths 1300349
Length Of Smallest Path 3
Average Path Length 25.8484
Length of Longest Path 59
Minimum Path Strength 1.235
Average Path Strength 5.9991
Maximum Path Strength 25.34
Minimum Path Correlation 0.7
Average Path Correlation 0.983755
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 47.4833
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.0345
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • sleep   • regulation of cytokinesis   • regulation of biological process   • regulation of cellular process   • positive regulation of cell division   • regulation of cell cycle process   • biological regulation   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cellular process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • establishment of organelle localization   • regulated exocytosis   • cellular localization   • response to stimulus   • transport   • cell activation involved in immune response   • leukocyte degranulation   • myeloid leukocyte activation   • myeloid leukocyte mediated immunity   • vesicle-mediated transport   • leukocyte activation   • localization   • secretion by cell   • organelle localization   • leukocyte activation involved in immune response   • establishment of localization in cell   • mast cell activation   • leukocyte mediated immunity   • mast cell mediated immunity   • immune response   • secretion   • cell activation   • vacuolar localization   • export from cell   • mast cell degranulation   • establishment of localization   • myeloid cell activation involved in immune response   • immune effector process   • mast cell activation involved in immune response   • exocytosis   • immune system process   • lysosome localization   • cellular response to stimulus   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • system process   • sensory perception   • nervous system process   • sensory perception of pain   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cellular component organization or biogenesis   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VUZ_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKTGI VETHFTFKD LHFKMFDVG GQRSERKKW IHCFEGVTA 
IIFCVALSD YDLVLMNRM HESMKLFDS ICNNKWFTD TSIILFLNK 
KDLFEEKIK KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD 
TKEIYTHFT CATDTKNVQ FVFDAVTDV IIKNNLKDC GL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VUZ_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VUZ_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB1
Sequence
>7VUZ_Chain_R
VFLILFIAL VGLVGNGFV LWLLGFRMR RNAFSVYVL SLAGADFLF 
LCFQIINCL VYLSNFFCS ISINFPSFF TTVMTCAYL AGLSMLSTV 
STERCLSVL WPIWYRCRR PRHLSAVVC VLLWALSLL LSILEGKFC 
GFLFSDGDS GWCQTFDFI TAAWLIFLF MVLCGSSLA LLVRILCGS 
RGLPLTRLY LTILLTVLV FLLCGLPFG IQWFLILWI WKDSDVLFC 
HIHPVSVVL SSLNSSANP IIYFFVGS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VV6AOrphanOrphanMRGPRX2Homo sapiensC48/80--3.32021-12-0110.1038/s41586-021-04077-y
7VV4AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14--2.972021-12-0110.1038/s41586-021-04077-y
7VV0AOrphanOrphanMRGPRX2Homo sapiensPAMP-12--3.52021-12-0110.1038/s41586-021-04077-y
7VV5AOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.762021-12-0110.1038/s41586-021-04077-y
7VV5 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.762021-12-0110.1038/s41586-021-04077-y
7VV3AOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.972021-12-0110.1038/s41586-021-04077-y
7VV3 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.972021-12-0110.1038/s41586-021-04077-y
7VUZAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.892021-12-0110.1038/s41586-021-04077-y
7VUZ (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.892021-12-0110.1038/s41586-021-04077-y
7VUYAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.842021-12-0110.1038/s41586-021-04077-y
7VUY (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.842021-12-0110.1038/s41586-021-04077-y
7VDMAOrphanOrphanMRGPRX2Homo sapiensSubstance-P-Gi1/β1/γ22.982021-12-0110.1038/s41586-021-04077-y
7VDM (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensSubstance-P-2.982021-12-0110.1038/s41586-021-04077-y
7VDLAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ23.222021-12-0110.1038/s41586-021-04077-y
7VDL (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-3.222021-12-0110.1038/s41586-021-04077-y
7VDHAOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.92021-12-0110.1038/s41586-021-04077-y
7VDH (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.92021-12-0110.1038/s41586-021-04077-y
7S8NAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ22.92021-11-1710.1038/s41586-021-04126-6
7S8N (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.92021-11-1710.1038/s41586-021-04126-6
7S8LAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ22.452021-11-1710.1038/s41586-021-04126-6
7S8L (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.452021-11-1710.1038/s41586-021-04126-6
7S8OAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-Gi1/β1/γ22.582021-11-1710.1038/s41586-021-04126-6
7S8O (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.582021-11-1710.1038/s41586-021-04126-6
7S8MAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ22.542021-11-1710.1038/s41586-021-04126-6
7S8M (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.542021-11-1710.1038/s41586-021-04126-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VUZ.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.