psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:R1	7.21	No	Yes	0	0	0
2	L:L:K3	L:L:R1	3.71	No	Yes	0	0	0
3	L:L:R1	R:R:C168	5.57	Yes	No	4	0	6
4	L:L:R1	R:R:C180	4.18	Yes	No	4	0	9
5	L:L:R1	R:R:W243	24.99	Yes	No	0	0	4
6	L:L:R1	R:R:L247	6.07	Yes	No	0	0	3
7	L:L:R1	R:R:W248	4	Yes	Yes	0	0	3
8	L:L:P2	R:R:F170	10.11	No	No	0	0	3
9	R:R:I32	R:R:P33	3.39	No	Yes	0	5	4
10	R:R:P262	R:R:P33	3.9	No	Yes	0	1	4
11	R:R:L90	R:R:V34	4.47	No	No	0	4	4
12	R:R:F35	R:R:L90	8.53	No	No	0	4	4
13	R:R:I37	R:R:Q82	4.12	Yes	Yes	2	6	5
14	R:R:I37	R:R:V265	4.61	Yes	No	2	6	4
15	R:R:I37	R:R:V266	4.61	Yes	No	0	6	5
16	R:R:I37	R:R:S269	7.74	Yes	No	0	6	5
17	R:R:C86	R:R:L38	6.35	No	No	0	5	5
18	R:R:F39	R:R:V43	5.24	No	No	0	5	5
19	R:R:I40	R:R:L270	4.28	No	No	0	7	6
20	R:R:A41	R:R:L79	3.15	No	No	0	5	7
21	R:R:A41	R:R:I83	3.25	No	Yes	0	5	6
22	R:R:F76	R:R:L45	7.31	No	No	0	7	7
23	R:R:I83	R:R:L45	4.28	Yes	No	0	6	7
24	R:R:G47	R:R:P276	4.06	No	No	0	8	9
25	R:R:A72	R:R:N48	4.69	No	No	0	9	9
26	R:R:D75	R:R:N48	10.77	No	No	0	9	9
27	R:R:N48	R:R:P276	11.4	No	No	0	9	9
28	R:R:G49	R:R:L52	3.42	No	No	0	6	8
29	R:R:A72	R:R:V51	3.39	No	No	0	9	9
30	R:R:F280	R:R:V51	10.49	Yes	No	5	8	9
31	R:R:F281	R:R:V51	3.93	No	No	5	6	9
32	R:R:L52	R:R:L69	4.15	No	No	0	8	7
33	R:R:R58	R:R:W53	12	No	No	0	5	6
34	R:R:L55	R:R:S65	7.51	No	No	0	8	8
35	R:R:L55	R:R:L69	6.92	No	No	0	8	7
36	R:R:F280	R:R:L55	8.53	Yes	No	0	8	8
37	R:R:L69	R:R:R61	4.86	No	No	0	7	7
38	R:R:N62	R:R:S65	4.47	No	No	0	8	8
39	R:R:A63	R:R:R141	5.53	No	Yes	0	7	8
40	R:R:F64	R:R:V68	3.93	No	No	0	7	8
41	R:R:F64	R:R:V123	7.87	No	No	1	7	9
42	R:R:F64	R:R:R127	3.21	No	No	1	7	9
43	R:R:S146	R:R:V66	8.08	No	No	0	9	6
44	R:R:T122	R:R:Y67	7.49	No	Yes	0	7	7
45	R:R:E126	R:R:Y67	11.22	No	Yes	0	9	7
46	R:R:S146	R:R:Y67	13.99	No	Yes	0	9	7
47	R:R:V149	R:R:Y67	3.79	No	Yes	0	6	7
48	R:R:F280	R:R:V68	3.93	Yes	No	0	8	8
49	R:R:M119	R:R:S70	6.13	No	No	1	6	9
50	R:R:C150	R:R:S70	5.16	No	No	1	7	9
51	R:R:L71	R:R:M119	5.65	No	No	1	9	6
52	R:R:L120	R:R:L71	5.54	Yes	No	1	9	9
53	R:R:L71	R:R:N275	8.24	No	Yes	1	9	9
54	R:R:A74	R:R:W154	3.89	No	No	0	9	9
55	R:R:D75	R:R:L79	4.07	No	No	2	9	7
56	R:R:D75	R:R:S272	8.83	No	No	2	9	9
57	R:R:A112	R:R:L77	3.15	No	No	0	7	6
58	R:R:F78	R:R:Q82	7.03	Yes	Yes	2	6	5
59	R:R:F78	R:R:M109	7.46	Yes	No	2	6	4
60	R:R:F78	R:R:Y113	6.19	Yes	Yes	2	6	8
61	R:R:F78	R:R:S268	3.96	Yes	No	2	6	8
62	R:R:F78	R:R:S272	3.96	Yes	No	2	6	9
63	R:R:L79	R:R:S272	7.51	No	No	2	7	9
64	R:R:F81	R:R:V108	5.24	No	No	0	5	6
65	R:R:F81	R:R:M109	4.98	No	No	0	5	4
66	R:R:M109	R:R:Q82	5.44	No	Yes	2	4	5
67	R:R:Q82	R:R:V265	5.73	Yes	No	2	5	4
68	R:R:F101	R:R:V88	6.55	Yes	No	0	4	3
69	R:R:N92	R:R:S98	8.94	No	No	0	3	6
70	R:R:C95	R:R:I97	3.27	No	No	0	4	5
71	R:R:I97	R:R:I99	4.42	No	No	0	5	1
72	R:R:F101	R:R:I99	3.77	Yes	No	0	4	1
73	R:R:F101	R:R:P102	5.78	Yes	No	0	4	5
74	R:R:F101	R:R:F105	5.36	Yes	No	0	4	5
75	R:R:F104	R:R:P102	5.78	No	No	0	4	5
76	R:R:F170	R:R:S103	6.61	No	No	0	3	5
77	R:R:F104	R:R:F105	6.43	No	No	0	4	5
78	R:R:F104	R:R:F172	3.22	No	No	0	4	1
79	R:R:F170	R:R:T106	9.08	No	No	0	3	5
80	R:R:S161	R:R:T107	6.4	No	No	0	7	4
81	R:R:S161	R:R:T110	3.2	No	No	0	7	2
82	R:R:E164	R:R:T110	5.64	No	No	3	4	2
83	R:R:F244	R:R:T110	3.89	Yes	No	3	5	2
84	R:R:C111	R:R:L158	3.17	No	No	0	5	4
85	R:R:C111	R:R:S161	3.44	No	No	0	5	7
86	R:R:L117	R:R:Y113	5.86	No	Yes	0	8	8
87	R:R:F239	R:R:Y113	16.5	Yes	Yes	2	6	8
88	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
89	R:R:S268	R:R:Y113	5.09	No	Yes	2	8	8
90	R:R:A115	R:R:W154	10.37	No	No	0	7	9
91	R:R:A115	R:R:S157	3.42	No	No	0	7	8
92	R:R:F232	R:R:L117	8.53	Yes	No	0	9	8
93	R:R:L153	R:R:S118	7.51	No	No	0	7	8
94	R:R:S118	R:R:W190	4.94	No	Yes	7	8	7
95	R:R:L194	R:R:S118	6.01	No	No	7	8	8
96	R:R:C150	R:R:M119	4.86	No	No	1	7	6
97	R:R:F232	R:R:L120	6.09	Yes	Yes	0	9	9
98	R:R:L120	R:R:N271	4.12	Yes	Yes	1	9	9
99	R:R:L120	R:R:N275	8.24	Yes	Yes	1	9	9
100	R:R:L120	R:R:Y279	9.38	Yes	Yes	1	9	9
101	R:R:L194	R:R:S121	4.5	No	No	0	8	7
102	R:R:S121	R:R:V197	3.23	No	No	0	7	6
103	R:R:L153	R:R:T122	4.42	No	No	0	7	7
104	R:R:R127	R:R:V123	6.54	No	No	1	9	9
105	R:R:V123	R:R:Y279	3.79	No	Yes	1	9	9
106	R:R:S124	R:R:S201	4.89	No	No	0	9	8
107	R:R:S124	R:R:S202	3.26	No	No	0	9	8
108	R:R:S201	R:R:T125	4.8	No	No	0	8	7
109	R:R:E126	R:R:Y137	6.73	No	No	6	9	7
110	R:R:E126	R:R:R141	8.14	No	Yes	6	9	8
111	R:R:R127	R:R:Y279	4.12	No	Yes	1	9	9
112	R:R:C128	R:R:L132	4.76	No	No	0	8	6
113	R:R:C128	R:R:S201	3.44	No	No	0	8	8
114	R:R:S130	R:R:Y137	7.63	No	No	0	8	7
115	R:R:L205	R:R:V131	4.47	No	No	0	8	8
116	R:R:R208	R:R:V131	5.23	No	No	0	7	8
117	R:R:L132	R:R:W133	6.83	No	No	0	6	5
118	R:R:L132	R:R:R208	4.86	No	No	0	6	7
119	R:R:R140	R:R:W136	7	No	No	0	6	6
120	R:R:R141	R:R:W136	4	Yes	No	0	8	6
121	R:R:R141	R:R:Y137	10.29	Yes	No	6	8	7
122	R:R:C139	R:R:R138	4.18	No	No	0	7	7
123	R:R:L145	R:R:R141	3.64	No	Yes	0	5	8
124	R:R:L145	R:R:P142	4.93	No	No	0	5	7
125	R:R:H144	R:R:R143	5.64	No	No	0	5	5
126	R:R:L156	R:R:W190	9.11	No	Yes	0	6	7
127	R:R:L159	R:R:L163	4.15	No	No	0	4	8
128	R:R:L160	R:R:T187	7.37	No	No	0	4	4
129	R:R:L160	R:R:W190	5.69	No	Yes	0	4	7
130	R:R:F183	R:R:L163	8.53	Yes	No	0	4	8
131	R:R:E164	R:R:F244	9.33	No	Yes	3	4	5
132	R:R:F167	R:R:K166	11.17	No	No	0	4	3
133	R:R:F167	R:R:W179	7.02	No	No	8	4	2
134	R:R:F167	R:R:F183	6.43	No	Yes	8	4	4
135	R:R:C168	R:R:C180	7.28	No	No	4	6	9
136	R:R:D174	R:R:G169	3.35	No	No	0	2	1
137	R:R:F172	R:R:L171	3.65	No	No	0	1	1
138	R:R:D174	R:R:G175	3.35	No	No	0	2	3
139	R:R:D176	R:R:W179	5.58	No	No	0	3	2
140	R:R:F183	R:R:W179	4.01	Yes	No	8	4	2
141	R:R:Q181	R:R:W248	18.62	No	Yes	0	3	3
142	R:R:D184	R:R:T187	4.34	No	No	3	3	4
143	R:R:D184	R:R:F244	7.17	No	Yes	3	3	5
144	R:R:D184	R:R:W248	8.93	No	Yes	0	3	3
145	R:R:F185	R:R:W248	5.01	No	Yes	0	3	3
146	R:R:F244	R:R:T187	7.78	Yes	No	3	5	4
147	R:R:A188	R:R:L245	4.73	No	No	0	5	5
148	R:R:L194	R:R:W190	11.39	No	Yes	7	8	7
149	R:R:L191	R:R:L237	5.54	No	No	0	7	6
150	R:R:F193	R:R:V197	6.55	No	No	0	5	6
151	R:R:C199	R:R:F195	8.38	No	No	0	5	6
152	R:R:F195	R:R:F232	6.43	No	Yes	0	6	9
153	R:R:F195	R:R:L233	8.53	No	No	0	6	7
154	R:R:F232	R:R:L198	12.18	Yes	No	0	9	8
155	R:R:S202	R:R:V229	3.23	No	No	0	8	8
156	R:R:I225	R:R:L205	5.71	No	No	0	7	8
157	R:R:I225	R:R:L206	8.56	No	No	0	7	5
158	R:R:I209	R:R:L221	5.71	Yes	No	0	6	8
159	R:R:L216	R:R:S213	9.01	No	No	0	4	7
160	R:R:L218	R:R:S213	6.01	No	No	0	7	7
161	R:R:P217	R:R:R220	7.21	No	No	0	5	8
162	R:R:L221	R:R:P217	3.28	No	No	0	8	5
163	R:R:T219	R:R:Y222	3.75	No	No	0	5	6
164	R:R:I278	R:R:L227	4.28	No	No	0	8	7
165	R:R:T228	R:R:Y279	3.75	No	Yes	0	7	9
166	R:R:L230	R:R:L234	4.15	No	No	0	5	5
167	R:R:C235	R:R:V231	3.42	No	No	1	7	7
168	R:R:N271	R:R:V231	5.91	Yes	No	1	9	7
169	R:R:C235	R:R:N271	3.15	No	Yes	1	7	9
170	R:R:G236	R:R:N271	5.09	No	Yes	0	7	9
171	R:R:I241	R:R:L237	5.71	No	No	0	6	6
172	R:R:P238	R:R:S264	5.34	No	No	0	9	5
173	R:R:F239	R:R:Q242	4.68	Yes	Yes	0	6	1
174	R:R:F239	R:R:V265	5.24	Yes	No	2	6	4
175	R:R:F239	R:R:S268	6.61	Yes	No	2	6	8
176	R:R:I241	R:R:L245	4.28	No	No	0	6	5
177	R:R:I260	R:R:Q242	4.12	No	Yes	0	3	1
178	R:R:H261	R:R:Q242	13.6	No	Yes	0	2	1
179	R:R:Q242	R:R:S264	8.66	Yes	No	0	1	5
180	R:R:F244	R:R:W243	11.02	Yes	No	0	5	4
181	R:R:H261	R:R:W243	6.35	No	No	0	2	4
182	R:R:I246	R:R:W250	4.7	No	No	0	4	1
183	R:R:L247	R:R:L256	4.15	No	No	0	3	2
184	R:R:F257	R:R:H261	6.79	No	No	0	3	2
185	R:R:N271	R:R:N275	9.54	Yes	Yes	1	9	9
186	R:R:N275	R:R:Y279	4.65	Yes	Yes	1	9	9
187	R:R:I278	R:R:Y279	4.84	No	Yes	0	8	9
188	R:R:F280	R:R:F281	5.36	Yes	No	5	8	6
189	R:R:T122	R:R:T125	3.14	No	No	0	7	7
190	R:R:I40	R:R:S269	3.1	No	No	0	7	5
191	R:R:I40	R:R:S273	3.1	No	No	0	7	8
192	R:R:I97	R:R:S91	3.1	No	No	0	5	2
193	R:R:F57	R:R:G56	3.01	No	No	0	5	6
194	R:R:L114	R:R:S157	3	No	No	0	6	8
195	R:R:N92	R:R:S96	2.98	No	No	0	3	5
196	R:R:I241	R:R:I246	2.94	No	No	0	6	4
197	R:R:D254	R:R:V255	2.92	No	No	0	1	1
198	R:R:I83	R:R:L38	2.85	Yes	No	0	6	5
199	R:R:I83	R:R:L42	2.85	Yes	No	0	6	5
200	R:R:I162	R:R:L158	2.85	No	No	0	4	4
201	R:R:I209	R:R:L206	2.85	Yes	No	0	6	5
202	R:R:I209	R:R:L216	2.85	Yes	No	0	6	4
203	R:R:I209	R:R:L218	2.85	Yes	No	0	6	7
204	R:R:I84	R:R:N85	2.83	No	No	0	5	4
205	R:R:K166	R:R:L171	2.82	No	No	0	3	1
206	R:R:L114	R:R:L160	2.77	No	No	0	6	4
207	R:R:L117	R:R:L191	2.77	No	No	0	8	7
208	R:R:D252	R:R:D254	2.66	No	No	0	1	1
209	R:R:F81	R:R:I84	2.51	No	No	0	5	5
210	R:R:F101	R:R:I84	2.51	Yes	No	0	4	5
211	R:R:F183	R:R:I186	2.51	Yes	No	0	4	6
212	R:R:F280	R:R:M59	2.49	Yes	No	0	8	6
213	R:R:S177	R:R:W248	2.47	No	Yes	0	3	3
214	R:R:F280	R:R:L54	2.44	Yes	No	0	8	8
215	R:R:K251	R:R:W248	2.32	No	Yes	0	1	3
216	R:R:L54	R:R:W53	2.28	No	No	0	8	6
217	R:R:L129	R:R:W133	2.28	No	No	0	6	5
218	R:R:D252	R:R:W250	2.23	No	No	0	1	1
219	L:L:P2	R:R:G169	2.03	No	No	0	0	1
220	R:R:C211	R:R:G212	1.96	No	No	0	5	5
221	R:R:A74	R:R:G116	1.95	No	No	0	9	9
222	R:R:G44	R:R:S273	1.86	No	No	0	9	8
223	R:R:G212	R:R:S213	1.86	No	No	0	5	7
224	R:R:G165	R:R:T107	1.82	No	No	0	3	4
225	R:R:A204	R:R:C128	1.81	No	No	0	6	8
226	R:R:P33	R:R:V263	1.77	Yes	No	0	4	5
227	R:R:P33	R:R:V266	1.77	Yes	No	0	4	5
228	R:R:C86	R:R:V34	1.71	No	No	0	5	4
229	R:R:G73	R:R:L52	1.71	No	No	0	5	8
230	R:R:G200	R:R:L203	1.71	No	No	0	4	5
231	R:R:C211	R:R:V207	1.71	No	No	0	5	5
232	R:R:L267	R:R:P238	1.64	No	No	0	7	9
233	R:R:A274	R:R:I278	1.62	No	No	0	7	8
234	R:R:C80	R:R:L45	1.59	No	No	0	4	7
235	R:R:C235	R:R:L234	1.59	No	No	0	7	5
236	R:R:I277	R:R:V282	1.54	No	No	0	6	7
237	R:R:M59	R:R:S284	1.53	No	No	0	6	7
238	R:R:G56	R:R:R61	1.5	No	No	0	6	7
239	R:R:G215	R:R:R214	1.5	No	No	0	5	5
240	R:R:L87	R:R:V88	1.49	No	No	0	4	3
241	R:R:C258	R:R:H259	1.47	No	No	0	1	2
242	R:R:I192	R:R:M196	1.46	No	No	0	5	5
243	R:R:I249	R:R:L245	1.43	No	No	0	1	5
244	R:R:Q181	R:R:T182	1.42	No	No	0	3	2
245	R:R:A112	R:R:F78	1.39	No	Yes	0	7	6
246	R:R:C139	R:R:R140	1.39	No	No	0	7	6
247	R:R:L210	R:R:L218	1.38	No	No	0	5	7
248	R:R:P134	R:R:W133	1.35	No	No	0	9	5
249	R:R:I135	R:R:R140	1.25	No	No	0	6	6
250	R:R:L206	R:R:Y222	1.17	No	No	0	5	6
251	R:R:F281	R:R:F50	1.07	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R1	7.96143	7	4	0
2	R:R:P33	2.7075	4	0	4
3	R:R:I37	5.27	4	2	6
4	R:R:Y67	9.1225	4	0	7
5	R:R:F78	4.99833	6	2	6
6	R:R:Q82	5.58	4	2	5
7	R:R:I83	3.3075	4	0	6
8	R:R:F101	4.794	5	0	4
9	R:R:Y113	7.598	5	2	8
10	R:R:L120	6.674	5	1	9
11	R:R:R141	6.32	5	6	8
12	R:R:F183	5.37	4	8	4
13	R:R:W190	7.7825	4	7	7
14	R:R:I209	3.565	4	0	6
15	R:R:F232	8.3075	4	0	9
16	R:R:F239	8.2575	4	2	6
17	R:R:Q242	7.765	4	0	1
18	R:R:F244	7.838	5	3	5
19	R:R:W248	6.89167	6	0	3
20	R:R:N271	5.562	5	1	9
21	R:R:N275	7.6675	4	1	9
22	R:R:Y279	5.08833	6	1	9
23	R:R:F280	5.54	6	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:R1	11.3606	7.21	No	Yes	0	0	0
2	L:L:R1	R:R:W243	22.841	24.99	Yes	No	0	0	4
3	R:R:H261	R:R:W243	95.8714	6.35	No	No	0	2	4
4	R:R:H261	R:R:Q242	97.0761	13.6	No	Yes	0	2	1
5	R:R:F239	R:R:Q242	100	4.68	Yes	Yes	0	6	1
6	R:R:F239	R:R:V265	22.1269	5.24	Yes	No	2	6	4
7	R:R:F239	R:R:Y113	50.5445	16.5	Yes	Yes	2	6	8
8	R:R:F78	R:R:Y113	42.2953	6.19	Yes	Yes	2	6	8
9	R:R:F78	R:R:S272	41.4695	3.96	Yes	No	2	6	9
10	R:R:L79	R:R:S272	14.3564	7.51	No	No	2	7	9
11	R:R:A41	R:R:L79	14.4322	3.15	No	No	0	5	7
12	R:R:A41	R:R:I83	13.1597	3.25	No	Yes	0	5	6
13	R:R:F239	R:R:S268	31.8242	6.61	Yes	No	2	6	8
14	R:R:F78	R:R:S268	31.7165	3.96	Yes	No	2	6	8
15	R:R:Q82	R:R:V265	15.4773	5.73	Yes	No	2	5	4
16	R:R:D75	R:R:S272	26.0681	8.83	No	No	2	9	9
17	R:R:D75	R:R:N48	26.2795	10.77	No	No	0	9	9
18	R:R:A72	R:R:N48	23.0484	4.69	No	No	0	9	9
19	R:R:A72	R:R:V51	22.1708	3.39	No	No	0	9	9
20	R:R:F280	R:R:V51	18.9996	10.49	Yes	No	5	8	9
21	R:R:F280	R:R:L55	15.234	8.53	Yes	No	0	8	8
22	R:R:L55	R:R:L69	10.7463	6.92	No	No	0	8	7
23	R:R:F244	R:R:W243	80.0152	11.02	Yes	No	0	5	4
24	R:R:F244	R:R:T187	71.9175	7.78	Yes	No	3	5	4
25	R:R:L160	R:R:T187	76.1379	7.37	No	No	0	4	4
26	R:R:L160	R:R:W190	69.4563	5.69	No	Yes	0	4	7
27	R:R:S118	R:R:W190	62.6232	4.94	No	Yes	7	8	7
28	R:R:L153	R:R:S118	62.4237	7.51	No	No	0	7	8
29	R:R:L153	R:R:T122	61.3666	4.42	No	No	0	7	7
30	R:R:T122	R:R:Y67	21.6403	7.49	No	Yes	0	7	7
31	R:R:E126	R:R:Y67	16.315	11.22	No	Yes	0	9	7
32	R:R:E126	R:R:R141	12.3419	8.14	No	Yes	6	9	8
33	R:R:L117	R:R:Y113	28.9641	5.86	No	Yes	0	8	8
34	R:R:F232	R:R:L117	22.8848	8.53	Yes	No	0	9	8
35	R:R:F232	R:R:L120	20.1125	6.09	Yes	Yes	0	9	9
36	R:R:L120	R:R:Y279	12.5653	9.38	Yes	Yes	1	9	9
37	R:R:F78	R:R:M109	41.3459	7.46	Yes	No	2	6	4
38	R:R:M109	R:R:Q82	16.674	5.44	No	Yes	2	4	5
39	R:R:F81	R:R:M109	56.5399	4.98	No	No	0	5	4
40	R:R:F81	R:R:I84	53.5362	2.51	No	No	0	5	5
41	R:R:F101	R:R:I84	50.5046	2.51	Yes	No	0	4	5
42	R:R:F101	R:R:P102	20.0566	5.78	Yes	No	0	4	5
43	R:R:F101	R:R:F105	19.8612	5.36	Yes	No	0	4	5
44	R:R:F104	R:R:P102	18.4291	5.78	No	No	0	4	5
45	R:R:F104	R:R:F105	18.4291	6.43	No	No	0	4	5
46	R:R:F104	R:R:F172	33.5434	3.22	No	No	0	4	1
47	R:R:T122	R:R:T125	42.754	3.14	No	No	0	7	7
48	R:R:S201	R:R:T125	41.5733	4.8	No	No	0	8	7
49	R:R:C128	R:R:S201	36.7745	3.44	No	No	0	8	8
50	R:R:C128	R:R:L132	34.3253	4.76	No	No	0	8	6
51	R:R:L132	R:R:R208	29.3271	4.86	No	No	0	6	7
52	R:R:R208	R:R:V131	28.1663	5.23	No	No	0	7	8
53	R:R:L205	R:R:V131	26.8818	4.47	No	No	0	8	8
54	R:R:F172	R:R:L171	30.2246	3.65	No	No	0	1	1
55	R:R:K166	R:R:L171	26.8978	2.82	No	No	0	3	1
56	R:R:F167	R:R:K166	23.563	11.17	No	No	0	4	3
57	R:R:F167	R:R:F183	13.4788	6.43	No	Yes	8	4	4
58	R:R:L117	R:R:L191	11.229	2.77	No	No	0	8	7
59	R:R:L191	R:R:L237	10.2477	5.54	No	No	0	7	6
60	R:R:I225	R:R:L205	25.5974	5.71	No	No	0	7	8
61	R:R:I225	R:R:L206	24.3967	8.56	No	No	0	7	5
62	R:R:I209	R:R:L206	20.4675	2.85	Yes	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R1	R:R:C168	5.57	4	Yes	No	0	6	0	1
L:L:R1	R:R:C180	4.18	4	Yes	No	0	9	0	1
L:L:R1	R:R:W243	24.99	4	Yes	No	0	4	0	1
L:L:R1	R:R:L247	6.07	4	Yes	No	0	3	0	1
L:L:R1	R:R:W248	4	4	Yes	Yes	0	3	0	1
L:L:P2	R:R:F170	10.11	0	No	No	0	3	0	1
R:R:F170	R:R:S103	6.61	0	No	No	3	5	1	2
R:R:F170	R:R:T106	9.08	0	No	No	3	5	1	2
R:R:C168	R:R:C180	7.28	4	No	No	6	9	1	1
R:R:D174	R:R:G169	3.35	0	No	No	2	1	2	1
R:R:Q181	R:R:W248	18.62	0	No	Yes	3	3	2	1
R:R:D184	R:R:F244	7.17	3	No	Yes	3	5	2	2
R:R:D184	R:R:W248	8.93	3	No	Yes	3	3	2	1
R:R:F185	R:R:W248	5.01	0	No	Yes	3	3	2	1
R:R:F244	R:R:W243	11.02	3	Yes	No	5	4	2	1
R:R:H261	R:R:W243	6.35	0	No	No	2	4	2	1
R:R:L247	R:R:L256	4.15	0	No	No	3	2	1	2
R:R:S177	R:R:W248	2.47	0	No	Yes	3	3	2	1
R:R:K251	R:R:W248	2.32	0	No	Yes	1	3	2	1
L:L:P2	R:R:G169	2.03	0	No	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VDM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	236
Number of Links	251
Number of Hubs	23
Number of Links mediated by Hubs	97
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	40961
Length Of Smallest Path	3
Average Path Length	17.2625
Length of Longest Path	41
Minimum Path Strength	1.32
Average Path Strength	6.32662
Maximum Path Strength	18.005
Minimum Path Correlation	0.7
Average Path Correlation	0.920668
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	39.2191
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.2353
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • mast cell secretagogue receptor activity • sleep • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • sensory perception of pain • signaling receptor binding • substance P receptor binding • neurokinin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • neuropeptide signaling pathway • response to stress • multicellular organismal response to stress • response to pain • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • detection of stimulus • response to abiotic stimulus • detection of abiotic stimulus • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • tachykinin receptor signaling pathway • defense response • inflammatory response • behavior • multi-multicellular organism process • reproductive process • multicellular organismal reproductive process • reproductive behavior • insemination • mating behavior • multi-organism reproductive process • copulation • cellular response to growth factor stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • somatodendritic compartment • cell body • neuronal cell body • axon
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7VDM_nogp_Chain_R I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G S R G L P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W K D S D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	10.1038/s41586-021-04077-y
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VDM_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.