Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 6.6025445
2A:A:K46 3.735409
3A:A:L194 5.2325444
4A:A:F196 8.762547
5A:A:M198 6.66447
6A:A:F199 6.93615
7A:A:E207 5.432519
8A:A:R208 5.615419
9A:A:K210 5.8719
10A:A:W211 5.92429719
11A:A:I212 4.1375418
12A:A:F215 6.442519
13A:A:Y230 4.703336108
14A:A:D231 5.89754109
15A:A:F250 7.12667689
16A:A:W258 7.968336125
17A:A:T262 3.5225417
18A:A:L266 5.62489
19A:A:F267 5.838579
20A:A:N269 5.3525479
21A:A:L283 3.62407
22A:A:C286 4.9375406
23A:A:Y287 6.482867137
24A:A:Y290 9.834137
25A:A:Y296 6.66504
26A:A:F307 6.4075488
27A:A:Y320 7.55177
28A:A:T324 6.552579
29A:A:D328 6.92479
30A:A:N331 10.596578
31A:A:F336 6.754548
32A:A:C351 4.6575464
33A:A:L353 8.43407
34A:A:F354 2.406505
35B:B:L7 2.54408
36B:B:L14 2.822508
37B:B:L51 8.0925429
38B:B:H54 8.796529
39B:B:I58 4.4275409
40B:B:Y59 8.1985128
41B:B:W63 7.872507
42B:B:V71 4.3354188
43B:B:L79 5.13407
44B:B:I80 8.3475428
45B:B:I81 5.394187
46B:B:W82 8.91857729
47B:B:N88 5.5475407
48B:B:K89 7.08667629
49B:B:H91 5.2725405
50B:B:I93 5.3775407
51B:B:W99 7.45619
52B:B:Y105 4.684297186
53B:B:N110 6.9154194
54B:B:Y111 7.04254194
55B:B:V112 4.50254188
56B:B:Y124 4.458506
57B:B:T128 3.9665243
58B:B:E138 6.16754236
59B:B:Y145 5.975818
60B:B:F151 5.285409
61B:B:L152 4.252503
62B:B:Q156 4.95405
63B:B:T159 6.0925159
64B:B:C166 4.235438
65B:B:L168 5.472536
66B:B:W169 9.5265158
67B:B:F180 7.732537
68B:B:H183 8.01667639
69B:B:D186 6.31419
70B:B:V187 5.01439
71B:B:A193 3.0275404
72B:B:F199 7.122539
73B:B:C204 6.6325417
74B:B:D205 6.1125409
75B:B:K209 9.97436
76B:B:W211 8.47333638
77B:B:F222 9.3754118
78B:B:H225 7.778577169
79B:B:D228 7.2875419
80B:B:F234 6.46754115
81B:B:F235 6.795266
82B:B:F241 6.892867116
83B:B:D247 7.455169
84B:B:T249 5.9754166
85B:B:R251 10.6365168
86B:B:F253 10.354116
87B:B:R256 7.57409
88B:B:D258 9.16254117
89B:B:M262 6.4175404
90B:B:Y264 8.05595
91B:B:R283 7.243336149
92B:B:L285 4.748596
93B:B:Y289 6.71714797
94B:B:C294 4.295455
95B:B:N295 8.4575496
96B:B:V296 4.3754275
97B:B:W297 6.656598
98B:B:H311 8.832559
99B:B:R314 12.13754128
100B:B:T329 6.0875408
101B:B:W332 11.52297129
102B:B:D333 6.57459
103B:B:L336 5.1575427
104B:B:K337 6.92556
105B:B:I338 5.125425
106B:B:W339 9.824559
107G:G:V16 3.34407
108G:G:R27 7.17408
109G:G:Y40 10.364266
110G:G:D48 7.248509
111G:G:L51 5.025406
112G:G:F61 5.48728
113R:R:L31 3.3725403
114R:R:I40 3.605407
115R:R:V51 4.8954299
116R:R:L52 3.2875408
117R:R:F64 5.4975467
118R:R:Y67 9.4075407
119R:R:F78 5.2345206
120R:R:Y89 4.395402
121R:R:I99 3.21401
122R:R:F101 5.325214
123R:R:T107 2.72404
124R:R:Y113 6.123336208
125R:R:R127 7.254569
126R:R:S130 5.065468
127R:R:Y137 6.522567
128R:R:R141 5.5825468
129R:R:F195 4.16754316
130R:R:I209 4.352506
131R:R:F232 8.385319
132R:R:L237 4.50254316
133R:R:F239 8.18254206
134R:R:F244 10.1075405
135R:R:W248 6.396503
136R:R:H261 8.225402
137R:R:I278 3.8375408
138R:R:Y279 4.72569
139R:R:F280 6.717298
140R:R:F281 4.0385296
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I58 14.50216.63YesYes099
2B:B:C317 B:B:I58 22.19313.27NoYes079
3B:B:C317 B:B:S316 32.74413.44NoNo079
4B:B:S316 B:B:W332 32.89624.94NoYes099
5B:B:K89 B:B:W82 13.585511.6YesYes299
6A:A:W258 B:B:W332 26.0483.75YesYes1259
7A:A:N256 A:A:W258 49.48116.78NoYes085
8A:A:I212 A:A:N256 49.60594.25YesNo088
9A:A:I212 A:A:R208 44.97455.01YesYes189
10A:A:L249 A:A:R208 99.95654.86NoYes099
11A:A:F223 A:A:L249 99.97186.09NoNo099
12A:A:F223 A:A:F250 10012.86NoYes099
13A:A:F250 A:A:L266 83.54366.09YesYes899
14A:A:L266 A:A:L268 83.634.15YesNo098
15A:A:F323 A:A:L268 84.52977.31NoNo048
16A:A:F323 A:A:Y296 85.27335.16NoYes044
17A:A:K271 A:A:Y296 85.03439.55NoYes054
18A:A:C325 A:A:K271 84.99853.23NoNo075
19A:A:C325 A:A:D328 84.88893.11NoYes079
20A:A:D328 A:A:T324 43.77477.23YesYes799
21A:A:F267 A:A:T324 40.79595.19YesYes799
22A:A:F267 A:A:I265 81.21893.77YesNo098
23A:A:I265 A:A:V335 77.37053.07NoNo088
24A:A:I222 A:A:V335 77.11573.07NoNo078
25A:A:I222 A:A:L36 76.86264.28NoNo077
26A:A:F196 A:A:L36 76.61146.09YesNo077
27A:A:D328 A:A:N331 40.926712.12YesYes798
28A:A:F267 A:A:N331 40.58749.67YesYes798
29A:A:F196 A:A:V339 74.3423.93YesNo478
30R:R:I209 R:R:S213 71.89274.64YesNo067
31R:R:L216 R:R:S213 72.16427.51NoNo047
32A:A:I344 R:R:L216 74.05314.28NoNo064
33A:A:I344 R:R:P134 74.32145.08NoNo069
34A:A:I343 R:R:P134 74.58923.39NoNo079
35A:A:I343 A:A:V339 75.12383.07NoNo078
36A:A:W211 B:B:Y145 57.43134.82YesYes198
37A:A:K210 B:B:Y145 32.34343.58YesYes198
38A:A:K210 B:B:D228 15.65996.91YesYes199
39A:A:K210 B:B:D246 15.66015.53YesNo199
40A:A:D231 A:A:Y230 12.93345.75YesYes1098
41A:A:M247 A:A:Y287 16.53183.59NoYes067
42R:R:I209 R:R:L221 61.42495.71YesNo068
43A:A:L353 R:R:L221 60.87215.54YesNo078
44A:A:L353 R:R:R127 60.042318.22YesYes079
45R:R:F64 R:R:R127 15.61883.21YesYes679
46B:B:D290 B:B:R314 18.5216.68NoYes068
47B:B:C271 B:B:D290 18.07056.22NoNo056
48B:B:C271 B:B:Y289 16.84534.03NoYes957
49B:B:F253 B:B:T243 22.79215.19YesNo068
50B:B:F222 B:B:F253 14.926812.86YesYes1186
51B:B:D258 B:B:F222 13.20353.58YesYes1178
52B:B:D258 B:B:R22 11.79459.53YesNo076
53B:B:I18 B:B:R22 10.06543.76NoNo076
54B:B:W297 B:B:Y289 10.62025.79YesYes987
55B:B:R314 B:B:T274 14.86883.88YesNo088
56B:B:S275 B:B:T274 14.61414.8NoNo088
57B:B:L318 B:B:S275 14.35937.51NoNo068
58B:B:L318 B:B:T329 14.10484.42NoYes068
59B:B:H62 B:B:Y105 10.88533.27NoYes066
60B:B:H62 B:B:R150 11.093414.67NoNo066
61B:B:C148 B:B:R150 11.30328.36NoNo066
62B:B:C148 B:B:L190 11.35883.17NoNo065
63B:B:H142 B:B:S161 10.55869.76NoNo099
64B:B:G162 B:B:Y145 10.64425.79NoYes198
65B:B:G162 B:B:S161 12.38623.71NoNo099
66B:B:L190 B:B:S160 15.68224.5NoNo056
67B:B:S147 B:B:S160 22.7263.26NoNo096
68B:B:H225 B:B:T243 23.93788.21YesNo098
69B:B:D228 B:B:S227 17.6165.89YesNo096
70B:B:D247 B:B:S227 32.64944.42YesNo096
71B:B:D246 B:B:S227 15.4855.89NoNo096
72B:B:D247 B:B:H225 26.8183.78YesYes1699
73R:R:R127 R:R:Y279 46.75764.12YesYes699
74R:R:L120 R:R:Y279 46.13725.86NoYes099
75R:R:F232 R:R:L120 40.87794.87YesNo099
76R:R:F232 R:R:L117 32.67226.09YesNo098
77R:R:L117 R:R:Y113 32.33977.03NoYes088
78R:R:F239 R:R:Y113 16.200210.32YesYes2068
79R:R:F64 R:R:V68 16.7573.93YesNo078
80R:R:F280 R:R:V68 16.38473.93YesNo088
81B:B:S147 B:B:Y145 22.95613.82NoYes098
82A:A:R208 A:A:W211 54.95156YesYes199
83B:B:C317 B:B:M61 10.46774.86NoNo076
84A:A:W258 B:B:R314 22.55054YesYes1258
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7VV3
Class A
SubFamily Orphan
Type A orphans
SubType MRGPRX2
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.97
Date 2021-12-01
D.O.I. 10.1038/s41586-021-04077-y
Net Summary
Imin 3.11
Number of Linked Nodes 813
Number of Links 958
Number of Hubs 140
Number of Links mediated by Hubs 530
Number of Communities 32
Number of Nodes involved in Communities 205
Number of Links involved in Communities 279
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 792106
Length Of Smallest Path 3
Average Path Length 30.9917
Length of Longest Path 70
Minimum Path Strength 1.115
Average Path Strength 5.92614
Maximum Path Strength 23.02
Minimum Path Correlation 0.7
Average Path Correlation 0.976189
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 45.3841
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.0946
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VV3_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKITG IVETHFTFK DLHFKMFDV GGQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC ATDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VV3_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VV3_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB1
Sequence
>7VV3_Chain_R
GKETLIPVF LILFIALVG LVGNGFVLW LLGFRMRRN AFSVYVLSL 
AGADFLFLC FQIINCLVY LSNFFCSIS INFPSFFTT VMTCAYLAG 
LSMLSTVST ERCLSVLWP IWYRCRRPR HLSAVVCVL LWALSLLLS 
ILEGKFCGF LFSDGDSGW CQTFDFITA AWLIFLFMV LCGSSLALL 
VRILCGSRG LPLTRLYLT ILLTVLVFL LCGLPFGIQ WFLILWIWK 
DSDVLFCHI HPVSVVLSS LNSSANPII YFFVGSFRK Q


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7S8LAOrphanA orphansMRGPRX2Homo sapiensCortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;22.452021-11-1710.1038/s41586-021-04126-6
7S8MAOrphanA orphansMRGPRX2Homo sapiensCortistatin-14-Gi1/&β;1/&γ;22.542021-11-1710.1038/s41586-021-04126-6
7S8NAOrphanA orphansMRGPRX2Homo sapiens(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;22.92021-11-1710.1038/s41586-021-04126-6
7S8OAOrphanA orphansMRGPRX2Homo sapiens(R)-Zinc-3573-Gi1/&β;1/&γ;22.582021-11-1710.1038/s41586-021-04126-6
7VDHAOrphanA orphansMRGPRX2Homo sapiensC48/80-Gi1/&β;1/&γ;22.92021-12-0110.1038/s41586-021-04077-y
7VDLAOrphanA orphansMRGPRX2Homo sapiensCortistatin-14-Gi1/&β;1/&γ;23.222021-12-0110.1038/s41586-021-04077-y
7VDMAOrphanA orphansMRGPRX2Homo sapiensSubstance P-Gi1/&β;1/&γ;22.982021-12-0110.1038/s41586-021-04077-y
7VUYAOrphanA orphansMRGPRX2Homo sapiens--Gi1/&β;1/&γ;22.842021-12-0110.1038/s41586-021-04077-y
7VUZAOrphanA orphansMRGPRX2Homo sapiens--Gi1/&β;1/&γ;22.892021-12-0110.1038/s41586-021-04077-y
7VV0AOrphanA orphansMRGPRX2Homo sapiensPAMP-12--3.52021-12-0110.1038/s41586-021-04077-y
7VV3AOrphanA orphansMRGPRX2Homo sapiens--Gi1/&β;1/&γ;22.972021-12-0110.1038/s41586-021-04077-y
7VV4AOrphanA orphansMRGPRX2Homo sapiensCortistatin-14--2.972021-12-0110.1038/s41586-021-04077-y
7VV5AOrphanA orphansMRGPRX2Homo sapiensC48/80-Gi1/&β;1/&γ;22.762021-12-0110.1038/s41586-021-04077-y
7VV6AOrphanA orphansMRGPRX2Homo sapiensC48/80--3.32021-12-0110.1038/s41586-021-04077-y




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Download 7VV3.zip



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