psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L22	4.91	Yes	No	2	0	1
2	L:L:?1	R:R:E164	3.52	Yes	Yes	2	0	4
3	L:L:?1	R:R:F170	5.4	Yes	No	0	0	3
4	L:L:?1	R:R:S177	5.32	Yes	No	0	0	3
5	L:L:?1	R:R:C180	4.22	Yes	No	2	0	9
6	L:L:?1	R:R:D184	8.42	Yes	Yes	2	0	3
7	L:L:?1	R:R:W243	22.2	Yes	Yes	2	0	4
8	L:L:?1	R:R:L247	4.91	Yes	No	0	0	3
9	L:L:?1	R:R:W248	16.15	Yes	Yes	2	0	3
10	L:L:?1	R:R:S253	7.98	Yes	No	0	0	1
11	R:R:L22	R:R:W243	4.56	No	Yes	2	1	4
12	R:R:L23	R:R:Y89	10.55	No	Yes	0	3	2
13	R:R:L24	R:R:Y89	7.03	No	Yes	0	5	2
14	R:R:L24	R:R:N92	9.61	No	No	0	5	3
15	R:R:F257	R:R:L25	7.31	No	No	0	3	2
16	R:R:C26	R:R:E29	6.08	No	No	0	1	1
17	R:R:C258	R:R:C26	7.28	No	No	0	1	1
18	R:R:G27	R:R:Y89	4.35	No	Yes	0	1	2
19	R:R:F93	R:R:K28	4.96	No	No	0	1	2
20	R:R:T30	R:R:Y89	6.24	No	Yes	0	3	2
21	R:R:P262	R:R:T30	3.5	No	No	0	1	3
22	R:R:F35	R:R:L31	4.87	No	No	0	4	3
23	R:R:L31	R:R:Y89	5.86	No	Yes	0	3	2
24	R:R:F93	R:R:L31	8.53	No	No	0	1	3
25	R:R:I32	R:R:P33	5.08	No	No	0	5	4
26	R:R:P262	R:R:P33	3.9	No	No	0	1	4
27	R:R:V34	R:R:Y89	10.09	No	Yes	0	4	2
28	R:R:L36	R:R:V266	4.47	No	No	0	5	5
29	R:R:I37	R:R:V265	6.14	No	No	0	6	4
30	R:R:L38	R:R:L42	4.15	No	No	0	5	5
31	R:R:C86	R:R:L38	7.94	No	No	0	5	5
32	R:R:I40	R:R:L270	5.71	No	No	0	7	6
33	R:R:I40	R:R:S273	4.64	No	No	0	7	8
34	R:R:I83	R:R:L42	5.71	No	No	0	6	5
35	R:R:G44	R:R:S273	3.71	No	No	0	9	8
36	R:R:F76	R:R:L45	9.74	No	No	0	7	7
37	R:R:I83	R:R:L45	4.28	No	No	0	6	7
38	R:R:A72	R:R:N48	4.69	No	No	0	9	9
39	R:R:D75	R:R:N48	10.77	Yes	No	0	9	9
40	R:R:N48	R:R:P276	13.03	No	No	0	9	9
41	R:R:F280	R:R:V51	10.49	Yes	No	4	8	9
42	R:R:F281	R:R:V51	3.93	Yes	No	4	6	9
43	R:R:F76	R:R:L52	4.87	No	No	0	7	8
44	R:R:L54	R:R:W53	6.83	No	No	0	8	6
45	R:R:F57	R:R:W53	5.01	No	No	0	5	6
46	R:R:R58	R:R:W53	7	No	No	0	5	6
47	R:R:F280	R:R:L54	4.87	Yes	No	0	8	8
48	R:R:L55	R:R:S65	6.01	No	No	0	8	8
49	R:R:L55	R:R:L69	5.54	No	No	0	8	7
50	R:R:F280	R:R:L55	9.74	Yes	No	0	8	8
51	R:R:F57	R:R:G56	4.52	No	No	0	5	6
52	R:R:F285	R:R:M59	3.73	Yes	No	0	6	6
53	R:R:R61	R:R:S65	3.95	No	No	0	7	8
54	R:R:L69	R:R:R61	3.64	No	No	0	7	7
55	R:R:N62	R:R:S65	5.96	No	No	0	8	8
56	R:R:A63	R:R:R141	4.15	No	Yes	0	7	8
57	R:R:F64	R:R:V68	3.93	No	No	0	7	8
58	R:R:F64	R:R:V123	7.87	No	No	1	7	9
59	R:R:F64	R:R:R127	6.41	No	No	1	7	9
60	R:R:S146	R:R:V66	9.7	No	No	0	9	6
61	R:R:T122	R:R:Y67	4.99	No	Yes	0	7	7
62	R:R:E126	R:R:Y67	13.47	No	Yes	0	9	7
63	R:R:S146	R:R:Y67	5.09	No	Yes	0	9	7
64	R:R:V149	R:R:Y67	3.79	No	Yes	0	6	7
65	R:R:F280	R:R:V68	3.93	Yes	No	0	8	8
66	R:R:M119	R:R:S70	4.6	Yes	No	1	6	9
67	R:R:C150	R:R:S70	5.16	No	No	1	7	9
68	R:R:S70	R:R:W154	4.94	No	Yes	0	9	9
69	R:R:D75	R:R:L71	5.43	Yes	Yes	1	9	9
70	R:R:L71	R:R:M119	4.24	Yes	Yes	1	9	6
71	R:R:L120	R:R:L71	5.54	Yes	Yes	1	9	9
72	R:R:L71	R:R:N275	6.87	Yes	Yes	1	9	9
73	R:R:L71	R:R:Y279	4.69	Yes	Yes	1	9	9
74	R:R:D75	R:R:S272	11.78	Yes	No	0	9	9
75	R:R:D75	R:R:N275	8.08	Yes	Yes	1	9	9
76	R:R:F78	R:R:Q82	11.71	Yes	No	5	6	5
77	R:R:F78	R:R:M109	3.73	Yes	No	5	6	4
78	R:R:F78	R:R:Y113	5.16	Yes	Yes	0	6	8
79	R:R:F78	R:R:S268	3.96	Yes	No	0	6	8
80	R:R:F78	R:R:S272	5.28	Yes	No	0	6	9
81	R:R:L79	R:R:S272	4.5	No	No	0	7	9
82	R:R:F105	R:R:F81	12.86	Yes	No	0	5	5
83	R:R:F81	R:R:V108	6.55	No	No	0	5	6
84	R:R:F81	R:R:M109	4.98	No	No	0	5	4
85	R:R:M109	R:R:Q82	6.8	No	No	5	4	5
86	R:R:Q82	R:R:V265	5.73	No	No	0	5	4
87	R:R:F101	R:R:I84	3.77	Yes	No	0	4	5
88	R:R:I97	R:R:S91	6.19	No	No	0	5	2
89	R:R:I99	R:R:S91	6.19	No	No	0	1	2
90	R:R:F93	R:R:F94	12.86	No	No	0	1	3
91	R:R:N100	R:R:S98	4.47	No	No	0	1	6
92	R:R:F101	R:R:I99	3.77	Yes	No	0	4	1
93	R:R:F101	R:R:P102	4.33	Yes	No	3	4	5
94	R:R:F101	R:R:F105	6.43	Yes	Yes	3	4	5
95	R:R:F104	R:R:P102	5.78	No	No	3	4	5
96	R:R:F105	R:R:P102	8.67	Yes	No	3	5	5
97	R:R:F104	R:R:F105	7.5	No	Yes	3	4	5
98	R:R:F170	R:R:T106	14.27	No	No	0	3	5
99	R:R:S161	R:R:T107	6.4	No	No	0	7	4
100	R:R:L171	R:R:T107	4.42	No	No	0	1	4
101	R:R:S161	R:R:T110	4.8	No	No	0	7	2
102	R:R:C111	R:R:L158	4.76	No	No	0	5	4
103	R:R:L117	R:R:Y113	7.03	No	Yes	0	8	8
104	R:R:F239	R:R:Y113	15.47	Yes	Yes	0	6	8
105	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
106	R:R:L114	R:R:L191	4.15	No	No	0	6	7
107	R:R:A115	R:R:W154	11.67	No	Yes	0	7	9
108	R:R:F232	R:R:L117	7.31	Yes	No	0	9	8
109	R:R:L153	R:R:S118	9.01	No	No	0	7	8
110	R:R:M119	R:R:T122	4.52	Yes	No	0	6	7
111	R:R:C150	R:R:M119	4.86	No	Yes	1	7	6
112	R:R:F232	R:R:L120	7.31	Yes	Yes	0	9	9
113	R:R:L120	R:R:N275	9.61	Yes	Yes	1	9	9
114	R:R:L120	R:R:Y279	5.86	Yes	Yes	1	9	9
115	R:R:L194	R:R:S121	7.51	No	No	0	8	7
116	R:R:L153	R:R:T122	4.42	No	No	0	7	7
117	R:R:R127	R:R:V123	6.54	No	No	1	9	9
118	R:R:V123	R:R:Y279	3.79	No	Yes	1	9	9
119	R:R:L198	R:R:S124	7.51	No	No	0	8	9
120	R:R:S124	R:R:S202	4.89	No	No	0	9	8
121	R:R:S201	R:R:T125	6.4	No	No	0	8	7
122	R:R:E126	R:R:R141	5.82	No	Yes	0	9	8
123	R:R:R127	R:R:Y279	6.17	No	Yes	1	9	9
124	R:R:C128	R:R:S201	6.89	No	No	0	8	8
125	R:R:L129	R:R:W133	6.83	No	No	0	6	5
126	R:R:S130	R:R:Y137	8.9	No	No	0	8	7
127	R:R:L205	R:R:V131	4.47	No	No	0	8	8
128	R:R:L132	R:R:R208	6.07	No	No	0	6	7
129	R:R:W133	R:R:W136	4.69	No	No	0	5	6
130	R:R:R140	R:R:W136	4	No	No	0	6	6
131	R:R:R141	R:R:W136	8	Yes	No	0	8	6
132	R:R:R141	R:R:Y137	7.2	Yes	No	0	8	7
133	R:R:C139	R:R:R138	4.18	No	No	0	7	7
134	R:R:L145	R:R:R141	8.5	No	Yes	0	5	8
135	R:R:H144	R:R:R143	14.67	No	No	0	5	5
136	R:R:L156	R:R:W190	5.69	No	Yes	0	6	7
137	R:R:L160	R:R:T187	5.9	No	No	0	4	4
138	R:R:F183	R:R:L163	9.74	No	No	0	4	8
139	R:R:C168	R:R:E164	4.56	No	Yes	0	6	4
140	R:R:D184	R:R:E164	7.8	Yes	Yes	2	3	4
141	R:R:E164	R:R:F244	5.83	Yes	Yes	2	4	5
142	R:R:F167	R:R:K166	13.65	No	No	0	4	3
143	R:R:D176	R:R:F167	7.17	No	No	0	3	4
144	R:R:F167	R:R:W179	13.03	No	No	0	4	2
145	R:R:C168	R:R:C180	7.28	No	No	0	6	9
146	R:R:F172	R:R:L171	4.87	No	No	0	1	1
147	R:R:G178	R:R:S177	3.71	No	No	0	3	3
148	R:R:T182	R:R:W179	3.64	No	No	0	2	2
149	R:R:C180	R:R:W248	3.92	No	Yes	2	9	3
150	R:R:F185	R:R:Q181	4.68	No	No	0	3	3
151	R:R:Q181	R:R:W248	17.52	No	Yes	0	3	3
152	R:R:F183	R:R:I186	7.54	No	No	0	4	6
153	R:R:D184	R:R:F244	11.94	Yes	Yes	2	3	5
154	R:R:D184	R:R:W248	6.7	Yes	Yes	2	3	3
155	R:R:F244	R:R:T187	15.56	Yes	No	0	5	4
156	R:R:A188	R:R:L245	4.73	No	No	0	5	5
157	R:R:F193	R:R:W190	5.01	No	Yes	0	5	7
158	R:R:L194	R:R:W190	12.53	No	Yes	0	8	7
159	R:R:F193	R:R:M196	3.73	No	No	0	5	5
160	R:R:F193	R:R:V197	5.24	No	No	0	5	6
161	R:R:C199	R:R:F195	5.59	No	Yes	0	5	6
162	R:R:F195	R:R:F232	7.5	Yes	Yes	0	6	9
163	R:R:F195	R:R:L233	10.96	Yes	No	0	6	7
164	R:R:F195	R:R:L237	6.09	Yes	No	0	6	6
165	R:R:F232	R:R:L198	8.53	Yes	No	0	9	8
166	R:R:I225	R:R:L205	5.71	No	No	0	7	8
167	R:R:L206	R:R:Y222	8.21	No	No	0	5	6
168	R:R:I225	R:R:L206	8.56	No	No	0	7	5
169	R:R:L216	R:R:S213	7.51	No	No	0	4	7
170	R:R:P217	R:R:R220	4.32	No	No	0	5	8
171	R:R:L226	R:R:Y222	9.38	No	No	0	5	6
172	R:R:T228	R:R:Y279	7.49	No	Yes	0	7	9
173	R:R:C235	R:R:N271	4.72	No	No	0	7	9
174	R:R:G236	R:R:N271	6.79	No	No	0	7	9
175	R:R:I241	R:R:L237	5.71	No	No	0	6	6
176	R:R:F239	R:R:Q242	4.68	Yes	Yes	0	6	1
177	R:R:F239	R:R:W243	7.02	Yes	Yes	0	6	4
178	R:R:F239	R:R:S268	5.28	Yes	No	0	6	8
179	R:R:I260	R:R:Q242	4.12	No	Yes	0	3	1
180	R:R:H261	R:R:Q242	12.36	Yes	Yes	0	2	1
181	R:R:Q242	R:R:S264	10.11	Yes	No	0	1	5
182	R:R:F244	R:R:W243	9.02	Yes	Yes	2	5	4
183	R:R:H261	R:R:W243	4.23	Yes	Yes	0	2	4
184	R:R:I246	R:R:W250	4.7	No	No	0	4	1
185	R:R:F257	R:R:L247	6.09	No	No	0	3	3
186	R:R:I249	R:R:W250	4.7	No	No	0	1	1
187	R:R:L256	R:R:W250	4.56	No	No	0	2	1
188	R:R:D252	R:R:L256	5.43	No	No	0	1	2
189	R:R:F257	R:R:H261	7.92	No	Yes	0	3	2
190	R:R:H261	R:R:P262	4.58	Yes	No	0	2	1
191	R:R:H261	R:R:V265	4.15	Yes	No	0	2	4
192	R:R:N271	R:R:N275	10.9	No	Yes	0	9	9
193	R:R:N275	R:R:Y279	6.98	Yes	Yes	1	9	9
194	R:R:I278	R:R:Y279	6.04	Yes	Yes	0	8	9
195	R:R:F280	R:R:F281	6.43	Yes	Yes	4	8	6
196	R:R:F280	R:R:S284	9.25	Yes	No	0	8	7
197	R:R:G283	R:R:R286	4.5	No	No	0	9	7
198	R:R:F285	R:R:S284	6.61	Yes	No	0	6	7
199	R:R:F285	R:R:K287	12.41	Yes	No	0	6	6
200	R:R:Q288	R:R:W289	6.57	No	No	0	4	5
201	R:R:C111	R:R:S157	3.44	No	No	0	5	8
202	R:R:C111	R:R:S161	3.44	No	No	0	5	7
203	R:R:C86	R:R:V34	3.42	No	No	0	5	4
204	R:R:G73	R:R:L52	3.42	No	No	0	5	8
205	R:R:A115	R:R:S157	3.42	No	No	0	7	8
206	R:R:L160	R:R:W190	3.42	No	Yes	0	4	7
207	R:R:L145	R:R:P142	3.28	No	No	0	5	7
208	R:R:L221	R:R:P217	3.28	No	No	0	8	5
209	R:R:L267	R:R:P238	3.28	No	No	0	7	9
210	R:R:E164	R:R:G165	3.27	Yes	No	0	4	3
211	R:R:S124	R:R:S201	3.26	No	No	0	9	8
212	R:R:A41	R:R:I83	3.25	No	No	0	5	6
213	R:R:S202	R:R:V229	3.23	No	No	0	8	8
214	R:R:C86	R:R:L90	3.17	No	No	0	5	4
215	R:R:C235	R:R:L234	3.17	No	No	0	7	5
216	R:R:I225	R:R:S202	3.1	No	No	0	7	8
217	R:R:I37	R:R:V266	3.07	No	No	0	6	5
218	R:R:I99	R:R:V88	3.07	No	No	0	1	3
219	R:R:I278	R:R:V231	3.07	Yes	No	0	8	7
220	R:R:I162	R:R:T107	3.04	No	No	0	4	4
221	R:R:F76	R:R:G49	3.01	No	No	0	7	6
222	R:R:F183	R:R:W179	3.01	No	No	0	4	2
223	R:R:L79	R:R:S269	3	No	No	0	7	5
224	R:R:L114	R:R:S157	3	No	No	0	6	8
225	R:R:L218	R:R:S213	3	No	No	0	7	7
226	R:R:D254	R:R:S253	2.94	No	No	0	1	1
227	R:R:I186	R:R:L160	2.85	No	No	0	6	4
228	R:R:I209	R:R:L205	2.85	Yes	No	0	6	8
229	R:R:I209	R:R:L210	2.85	Yes	No	0	6	5
230	R:R:I209	R:R:L216	2.85	Yes	No	0	6	4
231	R:R:I209	R:R:L221	2.85	Yes	No	0	6	8
232	R:R:I278	R:R:L227	2.85	Yes	No	0	8	7
233	R:R:I249	R:R:L245	2.85	No	No	0	1	5
234	R:R:I260	R:R:L256	2.85	No	No	0	3	2
235	R:R:L159	R:R:L163	2.77	No	No	0	4	8
236	R:R:L230	R:R:L234	2.77	No	No	0	5	5
237	R:R:R208	R:R:V131	2.62	No	No	0	7	8
238	R:R:A74	R:R:W154	2.59	No	Yes	0	9	9
239	R:R:F285	R:R:Q288	2.34	Yes	No	0	6	4
240	R:R:L77	R:R:W154	2.28	No	Yes	0	6	9
241	R:R:G47	R:R:P276	2.03	No	No	0	8	9
242	R:R:G236	R:R:P238	2.03	No	No	0	7	9
243	R:R:C211	R:R:G212	1.96	No	No	0	5	5
244	R:R:A74	R:R:G116	1.95	No	No	0	9	9
245	R:R:G44	R:R:V43	1.84	No	No	0	9	5
246	R:R:G47	R:R:V46	1.84	No	No	0	8	5
247	R:R:G283	R:R:V282	1.84	No	No	0	9	7
248	R:R:A204	R:R:C128	1.81	No	No	0	6	8
249	R:R:G44	R:R:L79	1.71	No	No	0	9	7
250	R:R:G200	R:R:L203	1.71	No	No	0	4	5
251	R:R:C26	R:R:T30	1.69	No	No	0	1	3
252	R:R:I135	R:R:P134	1.69	No	No	0	6	9
253	R:R:D176	R:R:G175	1.68	No	No	0	3	3
254	R:R:C95	R:R:I97	1.64	No	No	0	4	5
255	R:R:A274	R:R:I278	1.62	No	Yes	0	7	8
256	R:R:C80	R:R:L45	1.59	No	No	0	4	7
257	R:R:C80	R:R:L77	1.59	No	No	0	4	6
258	R:R:A112	R:R:L77	1.58	No	No	0	7	6
259	R:R:I277	R:R:V282	1.54	No	No	0	6	7
260	R:R:G215	R:R:R214	1.5	No	No	0	5	5
261	R:R:N92	R:R:S98	1.49	No	No	0	3	6
262	R:R:L152	R:R:V148	1.49	No	No	0	4	4
263	R:R:L203	R:R:V207	1.49	No	No	0	5	5
264	R:R:L227	R:R:T224	1.47	No	No	0	7	7
265	R:R:I192	R:R:M196	1.46	No	No	0	5	5
266	R:R:D254	R:R:V255	1.46	No	No	0	1	1
267	R:R:L38	R:R:L87	1.38	No	No	0	5	4
268	R:R:L87	R:R:L90	1.38	No	No	0	4	4
269	R:R:L223	R:R:L226	1.38	No	No	0	6	5
270	R:R:D252	R:R:K251	1.38	No	No	0	1	1
271	R:R:L23	R:R:N85	1.37	No	No	0	3	4
272	R:R:P134	R:R:W133	1.35	No	No	0	9	5
273	R:R:F170	R:R:S103	1.32	No	No	0	3	5
274	R:R:F39	R:R:I40	1.26	No	No	0	5	7
275	R:R:F281	R:R:I277	1.26	Yes	No	0	6	6
276	R:R:E29	R:R:H259	1.23	No	No	0	1	2
277	R:R:D174	R:R:F172	1.19	No	No	0	2	1
278	R:R:F281	R:R:F50	1.07	Yes	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.303	10	2	0
2	R:R:Y67	6.835	4	0	7
3	R:R:L71	5.354	5	1	9
4	R:R:D75	9.015	4	1	9
5	R:R:F78	5.968	5	5	6
6	R:R:Y89	7.35333	6	0	2
7	R:R:F101	4.575	4	3	4
8	R:R:F105	8.865	4	3	5
9	R:R:Y113	8.0025	4	0	8
10	R:R:M119	4.555	4	1	6
11	R:R:L120	7.08	4	1	9
12	R:R:R141	6.734	5	0	8
13	R:R:W154	5.37	4	0	9
14	R:R:E164	4.996	5	2	4
15	R:R:D184	8.715	4	2	3
16	R:R:W190	6.6625	4	0	7
17	R:R:F195	7.535	4	0	6
18	R:R:I209	2.85	4	0	6
19	R:R:F232	7.6625	4	0	9
20	R:R:F239	8.1125	4	0	6
21	R:R:Q242	7.8175	4	0	1
22	R:R:W243	9.406	5	2	4
23	R:R:F244	10.5875	4	2	5
24	R:R:W248	11.0725	4	2	3
25	R:R:H261	6.648	5	0	2
26	R:R:N275	8.488	5	1	9
27	R:R:I278	3.395	4	0	8
28	R:R:Y279	5.86	7	1	9
29	R:R:F280	7.45167	6	4	8
30	R:R:F281	3.1725	4	4	6
31	R:R:F285	6.2725	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W243	40.305	22.2	Yes	Yes	2	0	4
2	R:R:H261	R:R:W243	30.8515	4.23	Yes	Yes	0	2	4
3	R:R:H261	R:R:P262	61.8712	4.58	Yes	No	0	2	1
4	R:R:P262	R:R:T30	54.8217	3.5	No	No	0	1	3
5	R:R:T30	R:R:Y89	43.7185	6.24	No	Yes	0	3	2
6	R:R:L24	R:R:Y89	10.9133	7.03	No	Yes	0	5	2
7	R:R:C26	R:R:T30	10.8916	1.69	No	No	0	1	3
8	R:R:L31	R:R:Y89	13.6159	5.86	No	Yes	0	3	2
9	R:R:V34	R:R:Y89	13.9849	10.09	No	Yes	0	4	2
10	R:R:H261	R:R:V265	33.337	4.15	Yes	No	0	2	4
11	R:R:C86	R:R:V34	11.8467	3.42	No	No	0	5	4
12	R:R:C86	R:R:L38	10.0613	7.94	No	No	0	5	5
13	R:R:L38	R:R:L42	10.4738	4.15	No	No	0	5	5
14	R:R:F239	R:R:W243	94.1119	7.02	Yes	Yes	0	6	4
15	R:R:F239	R:R:Y113	100	15.47	Yes	Yes	0	6	8
16	R:R:F78	R:R:Y113	31.1445	5.16	Yes	Yes	0	6	8
17	R:R:F78	R:R:S272	89.6293	5.28	Yes	No	0	6	9
18	R:R:L79	R:R:S272	19.835	4.5	No	No	0	7	9
19	R:R:G44	R:R:L79	14.94	1.71	No	No	0	9	7
20	R:R:G44	R:R:S273	10.0016	3.71	No	No	0	9	8
21	R:R:F239	R:R:S268	25.8371	5.28	Yes	No	0	6	8
22	R:R:F78	R:R:S268	26.3581	3.96	Yes	No	0	6	8
23	R:R:I83	R:R:L42	10.7614	5.71	No	No	0	6	5
24	R:R:I83	R:R:L45	11.5428	4.28	No	No	0	6	7
25	R:R:D75	R:R:S272	92.2668	11.78	Yes	No	0	9	9
26	R:R:D75	R:R:N48	11.6622	10.77	Yes	No	0	9	9
27	R:R:L117	R:R:Y113	80.496	7.03	No	Yes	0	8	8
28	R:R:F232	R:R:L117	80.5394	7.31	Yes	No	0	9	8
29	R:R:F232	R:R:L120	81.2232	7.31	Yes	Yes	0	9	9
30	R:R:L120	R:R:Y279	48.4235	5.86	Yes	Yes	1	9	9
31	R:R:V123	R:R:Y279	50.4586	3.79	No	Yes	1	9	9
32	R:R:F64	R:R:V123	48.8251	7.87	No	No	1	7	9
33	R:R:F64	R:R:V68	94.4049	3.93	No	No	0	7	8
34	R:R:F280	R:R:V68	90.8992	3.93	Yes	No	0	8	8
35	R:R:R127	R:R:Y279	50.3717	6.17	No	Yes	1	9	9
36	R:R:F64	R:R:R127	48.8305	6.41	No	No	1	7	9
37	R:R:F280	R:R:F281	22.4616	6.43	Yes	Yes	4	8	6
38	R:R:F280	R:R:L54	18.7714	4.87	Yes	No	0	8	8
39	R:R:L54	R:R:W53	15.0377	6.83	No	No	0	8	6
40	R:R:F280	R:R:L55	22.4942	9.74	Yes	No	0	8	8
41	R:R:L55	R:R:S65	11.2715	6.01	No	No	0	8	8
42	R:R:F280	R:R:S284	22.2283	9.25	Yes	No	0	8	7
43	R:R:F285	R:R:S284	18.5055	6.61	Yes	No	0	6	7
44	R:R:D75	R:R:L71	63.7706	5.43	Yes	Yes	1	9	9
45	R:R:L71	R:R:M119	83.9692	4.24	Yes	Yes	1	9	6
46	R:R:M119	R:R:T122	40.5166	4.52	Yes	No	0	6	7
47	R:R:T122	R:R:Y67	34.6231	4.99	No	Yes	0	7	7
48	R:R:E126	R:R:Y67	26.7379	13.47	No	Yes	0	9	7
49	R:R:E126	R:R:R141	24.8548	5.82	No	Yes	0	9	8
50	R:R:L120	R:R:L71	26.141	5.54	Yes	Yes	1	9	9
51	R:R:M119	R:R:S70	47.5064	4.6	Yes	No	1	6	9
52	R:R:S70	R:R:W154	46.1008	4.94	No	Yes	0	9	9
53	R:R:D75	R:R:N275	30.998	8.08	Yes	Yes	1	9	9
54	R:R:F78	R:R:M109	24.6595	3.73	Yes	No	5	6	4
55	R:R:Q82	R:R:V265	36.5822	5.73	No	No	0	5	4
56	R:R:F81	R:R:M109	28.9467	4.98	No	No	0	5	4
57	R:R:F105	R:R:F81	24.1819	12.86	Yes	No	0	5	5
58	R:R:F101	R:R:F105	17.1596	6.43	Yes	Yes	3	4	5
59	R:R:F101	R:R:I99	12.3677	3.77	Yes	No	0	4	1
60	R:R:A115	R:R:W154	27.2264	11.67	No	Yes	0	7	9
61	R:R:A115	R:R:S157	25.1967	3.42	No	No	0	7	8
62	R:R:C111	R:R:S157	19.0427	3.44	No	No	0	5	8
63	R:R:C111	R:R:S161	14.8858	3.44	No	No	0	5	7
64	R:R:S161	R:R:T107	10.6854	6.4	No	No	0	7	4
65	R:R:F244	R:R:T187	47.2079	15.56	Yes	No	0	5	4
66	R:R:L160	R:R:T187	44.9503	5.9	No	No	0	4	4
67	R:R:L160	R:R:W190	19.3955	3.42	No	Yes	0	4	7
68	R:R:F244	R:R:W243	54.2085	9.02	Yes	Yes	2	5	4
69	R:R:F232	R:R:L198	42.009	8.53	Yes	No	0	9	8
70	R:R:L198	R:R:S124	40.4461	7.51	No	No	0	8	9
71	R:R:S124	R:R:S202	32.4687	4.89	No	No	0	9	8
72	R:R:R141	R:R:W136	12.791	8	Yes	No	0	8	6
73	R:R:I225	R:R:S202	29.1746	3.1	No	No	0	7	8
74	R:R:I225	R:R:L205	20.9204	5.71	No	No	0	7	8
75	R:R:I186	R:R:L160	24.1439	2.85	No	No	0	6	4
76	R:R:F183	R:R:I186	21.7778	7.54	No	No	0	4	6
77	R:R:F183	R:R:W179	14.6144	3.01	No	No	0	4	2
78	R:R:F239	R:R:Q242	35.6542	4.68	Yes	Yes	0	6	1
79	R:R:I260	R:R:Q242	22.3422	4.12	No	Yes	0	3	1
80	R:R:I260	R:R:L256	20.0467	2.85	No	No	0	3	2
81	R:R:L256	R:R:W250	12.6065	4.56	No	No	0	2	1
82	R:R:H261	R:R:Q242	20.6653	12.36	Yes	Yes	0	2	1
83	R:R:I209	R:R:L205	14.1423	2.85	Yes	No	0	6	8
84	R:R:N271	R:R:N275	14.9617	10.9	No	Yes	0	9	9
85	R:R:I278	R:R:Y279	10.2458	6.04	Yes	Yes	0	8	9
86	R:R:F281	R:R:I277	15.0377	1.26	Yes	No	0	6	6
87	R:R:I277	R:R:V282	11.2932	1.54	No	No	0	6	7
88	R:R:L77	R:R:W154	18.9233	2.28	No	Yes	0	6	9
89	R:R:C80	R:R:L77	15.3959	1.59	No	No	0	4	6
90	R:R:C80	R:R:L45	13.9795	1.59	No	No	0	4	7
91	R:R:F78	R:R:Q82	30.8352	11.71	Yes	No	5	6	5
92	R:R:L71	R:R:Y279	39.4693	4.69	Yes	Yes	1	9	9
93	R:R:N275	R:R:Y279	23.1291	6.98	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L22	4.91	2	Yes	No	0	1	0	1
L:L:?1	R:R:E164	3.52	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:F170	5.4	2	Yes	No	0	3	0	1
L:L:?1	R:R:S177	5.32	2	Yes	No	0	3	0	1
L:L:?1	R:R:C180	4.22	2	Yes	No	0	9	0	1
L:L:?1	R:R:D184	8.42	2	Yes	Yes	0	3	0	1
L:L:?1	R:R:W243	22.2	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:L247	4.91	2	Yes	No	0	3	0	1
L:L:?1	R:R:W248	16.15	2	Yes	Yes	0	3	0	1
L:L:?1	R:R:S253	7.98	2	Yes	No	0	1	0	1
R:R:L22	R:R:W243	4.56	2	No	Yes	1	4	1	1
R:R:F170	R:R:T106	14.27	0	No	No	3	5	1	2
R:R:C168	R:R:E164	4.56	0	No	Yes	6	4	2	1
R:R:D184	R:R:E164	7.8	2	Yes	Yes	3	4	1	1
R:R:E164	R:R:F244	5.83	2	Yes	Yes	4	5	1	2
R:R:C168	R:R:C180	7.28	0	No	No	6	9	2	1
R:R:G178	R:R:S177	3.71	0	No	No	3	3	2	1
R:R:C180	R:R:W248	3.92	2	No	Yes	9	3	1	1
R:R:Q181	R:R:W248	17.52	0	No	Yes	3	3	2	1
R:R:D184	R:R:F244	11.94	2	Yes	Yes	3	5	1	2
R:R:D184	R:R:W248	6.7	2	Yes	Yes	3	3	1	1
R:R:F239	R:R:W243	7.02	0	Yes	Yes	6	4	2	1
R:R:F244	R:R:W243	9.02	2	Yes	Yes	5	4	2	1
R:R:H261	R:R:W243	4.23	0	Yes	Yes	2	4	2	1
R:R:F257	R:R:L247	6.09	0	No	No	3	3	2	1
R:R:F257	R:R:H261	7.92	0	No	Yes	3	2	2	2
R:R:E164	R:R:G165	3.27	2	Yes	No	4	3	1	2
R:R:D254	R:R:S253	2.94	0	No	No	1	1	2	1
R:R:F170	R:R:S103	1.32	0	No	No	3	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VV5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	259
Number of Links	278
Number of Hubs	31
Number of Links mediated by Hubs	115
Number of Communities	5
Number of Nodes involved in Communities	29
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	55638
Length Of Smallest Path	3
Average Path Length	13.3348
Length of Longest Path	27
Minimum Path Strength	1.165
Average Path Strength	6.51104
Maximum Path Strength	18.6233
Minimum Path Correlation	0.7
Average Path Correlation	0.922364
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	49.1661
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.0606
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • mast cell secretagogue receptor activity • sleep • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • sensory perception of pain
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	6IB
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	6IB
Name	2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine
Synonyms
Identifier
Formula	C32 H45 N3 O3
Molecular Weight	519.718
SMILES
PubChem	2855
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	0
Total Bonds	85
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7VV5_nogp_Chain_R L L L L C G K E T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G S R G L P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W K D S D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F R K Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6

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