psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K3	R:R:C168	4.85	Yes	No	1	0	6
2	L:L:K3	R:R:C180	3.23	Yes	Yes	1	0	9
3	L:L:K3	R:R:D184	8.3	Yes	Yes	1	0	3
4	L:L:K3	R:R:W243	9.28	Yes	Yes	1	0	4
5	L:L:K3	R:R:F244	2.48	Yes	Yes	1	0	5
6	L:L:K3	R:R:W248	3.48	Yes	Yes	1	0	3
7	L:L:N4	R:R:W243	5.65	No	Yes	0	0	4
8	L:L:N4	R:R:F257	3.62	No	No	0	0	3
9	L:L:F5	R:R:S103	10.57	No	No	3	0	5
10	L:L:F5	R:R:F170	9.65	No	Yes	3	0	3
11	L:L:F6	R:R:N85	6.04	Yes	No	0	0	4
12	L:L:F6	R:R:T106	7.78	Yes	Yes	0	0	5
13	L:L:F6	R:R:M109	4.98	Yes	No	0	0	4
14	L:L:F6	R:R:H261	5.66	Yes	Yes	0	0	2
15	L:L:W7	R:R:N85	11.3	No	No	0	0	4
16	L:L:W7	R:R:F105	28.06	No	Yes	0	0	5
17	L:L:W7	R:R:T106	6.06	No	Yes	0	0	5
18	L:L:K8	R:R:Y89	4.78	No	Yes	0	0	2
19	R:R:C258	R:R:T30	3.38	No	No	0	1	3
20	R:R:F35	R:R:L31	10.96	No	No	0	4	3
21	R:R:L31	R:R:Y89	4.69	No	Yes	0	3	2
22	R:R:I32	R:R:P33	5.08	No	No	0	5	4
23	R:R:P262	R:R:P33	3.9	No	No	0	1	4
24	R:R:C86	R:R:V34	3.42	No	No	0	5	4
25	R:R:V34	R:R:Y89	8.83	No	Yes	0	4	2
26	R:R:F35	R:R:L90	2.44	No	No	0	4	4
27	R:R:I37	R:R:Q82	4.12	No	No	4	6	5
28	R:R:I37	R:R:V265	6.14	No	Yes	4	6	4
29	R:R:I37	R:R:V266	3.07	No	No	0	6	5
30	R:R:C86	R:R:L38	7.94	No	No	0	5	5
31	R:R:I40	R:R:S273	3.1	No	No	0	7	8
32	R:R:A41	R:R:L79	3.15	No	Yes	0	5	7
33	R:R:A41	R:R:I83	3.25	No	Yes	0	5	6
34	R:R:I83	R:R:L42	2.85	Yes	No	0	6	5
35	R:R:G44	R:R:V43	3.68	No	No	0	9	5
36	R:R:G44	R:R:S273	3.71	No	No	0	9	8
37	R:R:F76	R:R:L45	2.44	No	No	0	7	7
38	R:R:L45	R:R:L79	4.15	No	Yes	0	7	7
39	R:R:F50	R:R:V46	3.93	No	No	0	5	5
40	R:R:D75	R:R:N48	17.5	Yes	No	5	9	9
41	R:R:N48	R:R:P276	3.26	No	No	5	9	9
42	R:R:F280	R:R:V51	3.93	Yes	No	2	8	9
43	R:R:F281	R:R:V51	3.93	Yes	No	2	6	9
44	R:R:L52	R:R:L69	2.77	No	No	0	8	7
45	R:R:L54	R:R:W53	3.42	No	No	0	8	6
46	R:R:L54	R:R:M59	4.24	No	No	2	8	6
47	R:R:F280	R:R:L54	2.44	Yes	No	2	8	8
48	R:R:L55	R:R:S65	4.5	Yes	No	0	8	8
49	R:R:L55	R:R:V68	2.98	Yes	No	0	8	8
50	R:R:L55	R:R:L69	2.77	Yes	No	0	8	7
51	R:R:F280	R:R:L55	7.31	Yes	Yes	0	8	8
52	R:R:M59	R:R:R58	2.48	No	No	0	6	5
53	R:R:F280	R:R:M59	3.73	Yes	No	2	8	6
54	R:R:R60	R:R:R61	4.26	No	Yes	0	6	7
55	R:R:R61	R:R:S65	5.27	Yes	No	0	7	8
56	R:R:R61	R:R:V66	5.23	Yes	No	0	7	6
57	R:R:L69	R:R:R61	4.86	No	Yes	0	7	7
58	R:R:N62	R:R:S65	5.96	No	No	0	8	8
59	R:R:A63	R:R:R141	4.15	No	Yes	0	7	8
60	R:R:F64	R:R:V123	5.24	No	No	0	7	9
61	R:R:S146	R:R:V66	4.85	No	No	0	9	6
62	R:R:T122	R:R:Y67	7.49	No	Yes	0	7	7
63	R:R:V123	R:R:Y67	3.79	No	Yes	0	9	7
64	R:R:E126	R:R:Y67	5.61	No	Yes	0	9	7
65	R:R:S146	R:R:Y67	8.9	No	Yes	0	9	7
66	R:R:C150	R:R:Y67	2.69	No	Yes	0	7	7
67	R:R:M119	R:R:S70	7.67	Yes	No	0	6	9
68	R:R:S70	R:R:W154	6.18	No	Yes	0	9	9
69	R:R:L71	R:R:M119	4.24	No	Yes	0	9	6
70	R:R:L120	R:R:L71	4.15	No	No	0	9	9
71	R:R:L71	R:R:N275	6.87	No	No	0	9	9
72	R:R:A74	R:R:W154	2.59	No	Yes	0	9	9
73	R:R:D75	R:R:L79	5.43	Yes	Yes	0	9	7
74	R:R:D75	R:R:S272	8.83	Yes	No	0	9	9
75	R:R:D75	R:R:P276	3.22	Yes	No	5	9	9
76	R:R:C80	R:R:F76	5.59	No	No	0	4	7
77	R:R:F78	R:R:L79	3.65	Yes	Yes	0	6	7
78	R:R:F78	R:R:M109	6.22	Yes	No	0	6	4
79	R:R:F78	R:R:S268	2.64	Yes	No	0	6	8
80	R:R:F78	R:R:S272	3.96	Yes	No	0	6	9
81	R:R:L79	R:R:S273	3	Yes	No	0	7	8
82	R:R:F105	R:R:F81	35.37	Yes	No	0	5	5
83	R:R:F81	R:R:V108	6.55	No	No	0	5	6
84	R:R:Q82	R:R:V265	8.6	No	Yes	4	5	4
85	R:R:I83	R:R:L87	2.85	Yes	No	0	6	4
86	R:R:F105	R:R:I84	8.79	Yes	No	0	5	5
87	R:R:I99	R:R:V88	4.61	No	No	7	1	3
88	R:R:F101	R:R:V88	2.62	No	No	7	4	3
89	R:R:L90	R:R:Y89	3.52	No	Yes	0	4	2
90	R:R:F93	R:R:Y89	3.09	No	Yes	0	1	2
91	R:R:N92	R:R:S98	5.96	No	No	0	3	6
92	R:R:F93	R:R:F94	5.36	No	No	0	1	3
93	R:R:F101	R:R:I99	11.3	No	No	7	4	1
94	R:R:F101	R:R:P102	4.33	No	No	0	4	5
95	R:R:F172	R:R:P102	4.33	No	No	0	1	5
96	R:R:S103	R:R:T106	4.8	No	Yes	3	5	5
97	R:R:F170	R:R:S103	7.93	Yes	No	3	3	5
98	R:R:F104	R:R:T107	3.89	No	No	0	4	4
99	R:R:F104	R:R:L171	3.65	No	No	0	4	1
100	R:R:F105	R:R:M109	3.73	Yes	No	0	5	4
101	R:R:F170	R:R:T106	3.89	Yes	Yes	3	3	5
102	R:R:S161	R:R:T107	3.2	No	No	0	7	4
103	R:R:L114	R:R:T110	2.95	No	No	0	6	2
104	R:R:C111	R:R:W154	2.61	Yes	Yes	0	5	9
105	R:R:C111	R:R:S157	3.44	Yes	No	0	5	8
106	R:R:C111	R:R:L158	3.17	Yes	No	0	5	4
107	R:R:C111	R:R:S161	5.16	Yes	No	0	5	7
108	R:R:L117	R:R:Y113	8.21	No	No	0	8	8
109	R:R:F239	R:R:Y113	13.41	No	No	0	6	8
110	R:R:G240	R:R:Y113	4.35	No	No	0	7	8
111	R:R:L114	R:R:T187	2.95	No	No	0	6	4
112	R:R:A115	R:R:W154	7.78	No	Yes	0	7	9
113	R:R:F232	R:R:L117	2.44	Yes	No	0	9	8
114	R:R:S118	R:R:W190	2.47	No	Yes	9	8	7
115	R:R:L194	R:R:S118	3	No	No	9	8	8
116	R:R:C150	R:R:M119	3.24	No	Yes	0	7	6
117	R:R:L153	R:R:M119	2.83	No	Yes	0	7	6
118	R:R:F232	R:R:L120	6.09	Yes	No	0	9	9
119	R:R:L120	R:R:Y279	7.03	No	No	0	9	9
120	R:R:L194	R:R:S121	6.01	No	No	0	8	7
121	R:R:R127	R:R:V123	3.92	No	No	0	9	9
122	R:R:L198	R:R:S124	3	No	No	0	8	9
123	R:R:S124	R:R:S201	4.89	No	Yes	0	9	8
124	R:R:S201	R:R:T125	4.8	Yes	No	0	8	7
125	R:R:E126	R:R:Y137	6.73	No	Yes	6	9	7
126	R:R:E126	R:R:R141	5.82	No	Yes	6	9	8
127	R:R:R127	R:R:T224	3.88	No	No	0	9	7
128	R:R:S130	R:R:Y137	7.63	No	Yes	0	8	7
129	R:R:L132	R:R:V131	2.98	No	No	0	6	8
130	R:R:L205	R:R:V131	8.94	No	No	0	8	8
131	R:R:I209	R:R:V131	3.07	No	No	0	6	8
132	R:R:L132	R:R:R208	4.86	No	No	0	6	7
133	R:R:W136	R:R:Y137	3.86	No	Yes	0	6	7
134	R:R:R140	R:R:W136	13	No	No	0	6	6
135	R:R:R141	R:R:Y137	11.32	Yes	Yes	6	8	7
136	R:R:C139	R:R:R138	2.79	No	No	0	7	7
137	R:R:P142	R:R:R141	2.88	No	Yes	0	7	8
138	R:R:L145	R:R:R141	6.07	No	Yes	0	5	8
139	R:R:R141	R:R:S146	5.27	Yes	No	0	8	9
140	R:R:L153	R:R:V149	2.98	No	No	0	7	6
141	R:R:I162	R:R:L158	4.28	No	No	0	4	4
142	R:R:L160	R:R:T187	2.95	No	No	0	4	4
143	R:R:F183	R:R:L163	8.53	No	No	0	4	8
144	R:R:E164	R:R:G165	3.27	Yes	No	0	4	3
145	R:R:D184	R:R:E164	7.8	Yes	Yes	1	3	4
146	R:R:E164	R:R:F244	7	Yes	Yes	1	4	5
147	R:R:F170	R:R:G165	3.01	Yes	No	0	3	3
148	R:R:F167	R:R:K166	9.93	No	No	0	4	3
149	R:R:K166	R:R:S173	7.65	No	No	0	3	1
150	R:R:F167	R:R:W179	4.01	No	No	0	4	2
151	R:R:C168	R:R:C180	7.28	No	Yes	1	6	9
152	R:R:D174	R:R:G175	6.71	No	No	0	2	3
153	R:R:C180	R:R:D184	4.67	Yes	Yes	1	9	3
154	R:R:C180	R:R:W248	2.61	Yes	Yes	1	9	3
155	R:R:F185	R:R:Q181	9.37	No	No	0	3	3
156	R:R:Q181	R:R:W248	10.95	No	Yes	0	3	3
157	R:R:F183	R:R:I186	2.51	No	No	0	4	6
158	R:R:D184	R:R:F244	9.55	Yes	Yes	1	3	5
159	R:R:D184	R:R:W248	6.7	Yes	Yes	1	3	3
160	R:R:F244	R:R:T187	3.89	Yes	No	0	5	4
161	R:R:A188	R:R:L245	3.15	No	No	0	5	5
162	R:R:F193	R:R:W190	3.01	No	Yes	0	5	7
163	R:R:L194	R:R:W190	7.97	No	Yes	9	8	7
164	R:R:F193	R:R:V197	5.24	No	No	0	5	6
165	R:R:F195	R:R:L198	2.44	Yes	No	8	6	8
166	R:R:C199	R:R:F195	6.98	No	Yes	0	5	6
167	R:R:F195	R:R:F232	6.43	Yes	Yes	8	6	9
168	R:R:F195	R:R:L233	9.74	Yes	No	0	6	7
169	R:R:F232	R:R:L198	4.87	Yes	No	8	9	8
170	R:R:I225	R:R:S202	3.1	No	No	0	7	8
171	R:R:S202	R:R:V229	3.23	No	No	0	8	8
172	R:R:L205	R:R:L221	2.77	No	No	0	8	8
173	R:R:L206	R:R:L210	5.54	No	No	0	5	5
174	R:R:I209	R:R:L221	4.28	No	No	0	6	8
175	R:R:L210	R:R:Y222	4.69	No	No	0	5	6
176	R:R:L218	R:R:Y222	11.72	No	No	0	7	6
177	R:R:R220	R:R:V282	5.23	No	No	0	8	7
178	R:R:I225	R:R:L221	4.28	No	No	0	7	8
179	R:R:L226	R:R:L230	2.77	No	No	0	5	5
180	R:R:L227	R:R:V231	2.98	No	No	0	7	7
181	R:R:T228	R:R:Y279	3.75	No	No	0	7	9
182	R:R:L230	R:R:V229	2.98	No	No	0	5	8
183	R:R:N271	R:R:V231	2.96	Yes	No	0	9	7
184	R:R:L233	R:R:L234	4.15	No	No	0	7	5
185	R:R:L233	R:R:L237	2.77	No	No	0	7	6
186	R:R:C235	R:R:N271	3.15	No	Yes	0	7	9
187	R:R:L267	R:R:P238	3.28	No	No	0	7	9
188	R:R:F239	R:R:S268	5.28	No	No	0	6	8
189	R:R:F244	R:R:G240	3.01	Yes	No	0	5	7
190	R:R:I241	R:R:Q242	2.74	No	Yes	0	6	1
191	R:R:I241	R:R:L245	2.85	No	No	0	6	5
192	R:R:I246	R:R:Q242	5.49	No	Yes	0	4	1
193	R:R:I260	R:R:Q242	4.12	No	Yes	0	3	1
194	R:R:Q242	R:R:S264	7.22	Yes	No	0	1	5
195	R:R:F244	R:R:W243	6.01	Yes	Yes	1	5	4
196	R:R:L247	R:R:W243	3.42	No	Yes	0	3	4
197	R:R:L256	R:R:V255	4.47	No	No	0	2	1
198	R:R:H259	R:R:L256	5.14	No	No	0	2	2
199	R:R:F257	R:R:H261	16.97	No	Yes	0	3	2
200	R:R:H261	R:R:P262	3.05	Yes	No	0	2	1
201	R:R:H261	R:R:V265	4.15	Yes	Yes	0	2	4
202	R:R:L267	R:R:V263	2.98	No	No	0	7	5
203	R:R:N271	R:R:N275	8.17	Yes	No	0	9	9
204	R:R:I277	R:R:I278	2.94	No	No	0	6	8
205	R:R:F281	R:R:I277	3.77	Yes	No	0	6	6
206	R:R:I278	R:R:Y279	4.84	No	No	0	8	9
207	R:R:F280	R:R:F281	6.43	Yes	Yes	2	8	6
208	R:R:I246	R:R:W250	2.35	No	No	0	4	1
209	R:R:E164	R:R:F183	2.33	Yes	No	0	4	4
210	R:R:L129	R:R:W133	2.28	No	No	0	6	5
211	R:R:L132	R:R:W133	2.28	No	No	0	6	5
212	R:R:G236	R:R:P238	2.03	No	No	0	7	9
213	R:R:C199	R:R:G200	1.96	No	No	0	5	4
214	R:R:A72	R:R:G73	1.95	No	No	0	9	5
215	R:R:A74	R:R:G116	1.95	No	No	0	9	9
216	R:R:A115	R:R:G116	1.95	No	No	0	7	9
217	R:R:G47	R:R:V46	1.84	No	No	0	8	5
218	R:R:G283	R:R:V282	1.84	No	No	0	9	7
219	R:R:A204	R:R:C128	1.81	No	No	0	6	8
220	R:R:P238	R:R:S264	1.78	No	No	0	9	5
221	R:R:P33	R:R:T30	1.75	No	No	0	4	3
222	R:R:C128	R:R:S201	1.72	No	Yes	0	8	8
223	R:R:G49	R:R:L52	1.71	No	No	0	6	8
224	R:R:G240	R:R:L191	1.71	No	No	0	7	7
225	R:R:A72	R:R:V51	1.7	No	No	0	9	9
226	R:R:G236	R:R:N271	1.7	No	Yes	0	7	9
227	R:R:C95	R:R:I97	1.64	No	No	0	4	5
228	R:R:G178	R:R:Q181	1.64	No	No	0	3	3
229	R:R:S124	R:R:S202	1.63	No	No	0	9	8
230	R:R:S201	R:R:V197	1.62	Yes	No	0	8	6
231	R:R:S269	R:R:V265	1.62	No	Yes	0	5	4
232	R:R:A274	R:R:I277	1.62	No	No	0	7	6
233	R:R:A112	R:R:L77	1.58	No	No	0	7	6
234	R:R:I97	R:R:S91	1.55	No	No	0	5	2
235	R:R:L77	R:R:V108	1.49	No	No	0	6	6
236	R:R:L203	R:R:V207	1.49	No	No	0	5	5
237	R:R:D176	R:R:S177	1.47	No	No	0	3	3
238	R:R:L223	R:R:T219	1.47	No	No	0	6	5
239	R:R:C258	R:R:H259	1.47	No	No	0	1	2
240	R:R:D254	R:R:V255	1.46	No	No	0	1	1
241	R:R:I32	R:R:L36	1.43	No	No	0	5	5
242	R:R:I83	R:R:L38	1.43	Yes	No	0	6	5
243	R:R:I225	R:R:L206	1.43	No	No	0	7	5
244	R:R:I209	R:R:L218	1.43	No	No	0	6	7
245	R:R:K166	R:R:L171	1.41	No	No	0	3	1
246	R:R:L159	R:R:L163	1.38	No	No	0	4	8
247	R:R:E29	R:R:K28	1.35	No	No	0	1	2
248	R:R:P134	R:R:W133	1.35	No	No	0	9	5
249	R:R:R220	R:R:T224	1.29	No	No	0	8	7
250	R:R:I135	R:R:R140	1.25	No	No	0	6	6
251	R:R:F195	R:R:M196	1.24	Yes	No	0	6	5
252	R:R:F93	R:R:N92	1.21	No	No	0	1	3
253	R:R:I249	R:R:W250	1.17	No	No	0	1	1
254	R:R:L156	R:R:W190	1.14	No	Yes	0	6	7
255	R:R:H144	R:R:R143	1.13	No	No	0	5	5
256	R:R:D176	R:R:W179	1.12	No	No	0	3	2
257	R:R:F281	R:R:F50	1.07	Yes	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:K3	5.27	6	1	0
2	L:L:F6	6.115	4	0	0
3	R:R:L55	4.39	4	0	8
4	R:R:R61	4.905	4	0	7
5	R:R:Y67	5.696	5	0	7
6	R:R:D75	8.745	4	5	9
7	R:R:F78	4.1175	4	0	6
8	R:R:L79	3.876	5	0	7
9	R:R:I83	2.595	4	0	6
10	R:R:Y89	4.982	5	0	2
11	R:R:F105	18.9875	4	0	5
12	R:R:T106	5.6325	4	3	5
13	R:R:C111	3.595	4	0	5
14	R:R:M119	4.495	4	0	6
15	R:R:Y137	7.385	4	6	7
16	R:R:R141	5.91833	6	6	8
17	R:R:W154	4.79	4	0	9
18	R:R:E164	5.1	4	1	4
19	R:R:F170	6.12	4	3	3
20	R:R:C180	4.4475	4	1	9
21	R:R:D184	7.404	5	1	3
22	R:R:W190	3.6475	4	9	7
23	R:R:F195	5.366	5	8	6
24	R:R:S201	3.2575	4	0	8
25	R:R:F232	4.9575	4	8	9
26	R:R:Q242	4.8925	4	0	1
27	R:R:W243	6.09	4	1	4
28	R:R:F244	5.32333	6	1	5
29	R:R:W248	5.935	4	1	3
30	R:R:H261	7.4575	4	0	2
31	R:R:V265	5.1275	4	4	4
32	R:R:N271	3.995	4	0	9
33	R:R:F280	4.768	5	2	8
34	R:R:F281	3.8	4	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N4	R:R:W243	19.3359	5.65	No	Yes	0	0	4
2	L:L:N4	R:R:F257	18.7739	3.62	No	No	0	0	3
3	R:R:E164	R:R:F244	11.6028	7	Yes	Yes	1	4	5
4	L:L:F6	R:R:H261	21.507	5.66	Yes	Yes	0	0	2
5	R:R:F257	R:R:H261	18.2886	16.97	No	Yes	0	3	2
6	L:L:F6	R:R:M109	25.2043	4.98	Yes	No	0	0	4
7	R:R:F244	R:R:G240	48.9464	3.01	Yes	No	0	5	7
8	R:R:G240	R:R:Y113	50.6322	4.35	No	No	0	7	8
9	R:R:F239	R:R:Y113	61.3793	13.41	No	No	0	6	8
10	R:R:F239	R:R:S268	60.6897	5.28	No	No	0	6	8
11	R:R:F78	R:R:S268	60.0192	2.64	Yes	No	0	6	8
12	R:R:F78	R:R:L79	37.8672	3.65	Yes	Yes	0	6	7
13	R:R:A41	R:R:L79	24.1571	3.15	No	Yes	0	5	7
14	R:R:A41	R:R:I83	22.8161	3.25	No	Yes	0	5	6
15	R:R:I83	R:R:L38	18.9017	1.43	Yes	No	0	6	5
16	R:R:C86	R:R:L38	17.5096	7.94	No	No	0	5	5
17	R:R:C86	R:R:V34	16.1047	3.42	No	No	0	5	4
18	R:R:V34	R:R:Y89	14.6743	8.83	No	Yes	0	4	2
19	R:R:H261	R:R:P262	23.7484	3.05	Yes	No	0	2	1
20	R:R:P262	R:R:P33	21.4304	3.9	No	No	0	1	4
21	R:R:P33	R:R:T30	14.3997	1.75	No	No	0	4	3
22	R:R:C258	R:R:T30	12.0307	3.38	No	No	0	1	3
23	R:R:H261	R:R:V265	11.7752	4.15	Yes	Yes	0	2	4
24	R:R:L117	R:R:Y113	99.8276	8.21	No	No	0	8	8
25	R:R:F232	R:R:L117	100	2.44	Yes	No	0	9	8
26	R:R:F232	R:R:L120	94.8212	6.09	Yes	No	0	9	9
27	R:R:L120	R:R:Y279	29.2912	7.03	No	No	0	9	9
28	R:R:I278	R:R:Y279	26.9157	4.84	No	No	0	8	9
29	R:R:I277	R:R:I278	25.6258	2.94	No	No	0	6	8
30	R:R:F281	R:R:I277	23.378	3.77	Yes	No	0	6	6
31	R:R:F280	R:R:F281	15.613	6.43	Yes	Yes	2	8	6
32	R:R:F280	R:R:L55	11.9093	7.31	Yes	Yes	0	8	8
33	R:R:L120	R:R:L71	75.9132	4.15	No	No	0	9	9
34	R:R:L71	R:R:M119	61.0728	4.24	No	Yes	0	9	6
35	R:R:C150	R:R:M119	37.7203	3.24	No	Yes	0	7	6
36	R:R:C150	R:R:Y67	36.6858	2.69	No	Yes	0	7	7
37	R:R:S146	R:R:Y67	14.8404	8.9	No	Yes	0	9	7
38	R:R:S146	R:R:V66	10.9259	4.85	No	No	0	9	6
39	R:R:E126	R:R:Y67	13.3653	5.61	No	Yes	0	9	7
40	R:R:V123	R:R:Y67	11.0728	3.79	No	Yes	0	9	7
41	R:R:M119	R:R:S70	30.1341	7.67	Yes	No	0	6	9
42	R:R:S70	R:R:W154	28.7484	6.18	No	Yes	0	9	9
43	R:R:L71	R:R:N275	26.9349	6.87	No	No	0	9	9
44	R:R:C111	R:R:W154	21.6284	2.61	Yes	Yes	0	5	9
45	R:R:C111	R:R:S161	15.7024	5.16	Yes	No	0	5	7
46	R:R:S161	R:R:T107	14.189	3.2	No	No	0	7	4
47	R:R:F104	R:R:T107	12.6628	3.89	No	No	0	4	4
48	R:R:F104	R:R:L171	11.1239	3.65	No	No	0	4	1
49	R:R:F232	R:R:L198	48.7037	4.87	Yes	No	8	9	8
50	R:R:L198	R:R:S124	49.2976	3	No	No	0	8	9
51	R:R:S124	R:R:S201	16.8391	4.89	No	Yes	0	9	8
52	R:R:S201	R:R:V197	10.9962	1.62	Yes	No	0	8	6
53	R:R:S124	R:R:S202	34.5402	1.63	No	No	0	9	8
54	R:R:I225	R:R:S202	29.1443	3.1	No	No	0	7	8
55	R:R:I225	R:R:L221	23.5824	4.28	No	No	0	7	8
56	R:R:L205	R:R:L221	10.447	2.77	No	No	0	8	8
57	R:R:L132	R:R:V131	15.3065	2.98	No	No	0	6	8
58	R:R:I209	R:R:L221	11.7241	4.28	No	No	0	6	8
59	R:R:N271	R:R:N275	25.5364	8.17	Yes	No	0	9	9
60	R:R:G236	R:R:N271	19.8148	1.7	No	Yes	0	7	9
61	R:R:G236	R:R:P238	18.3525	2.03	No	No	0	7	9
62	R:R:P238	R:R:S264	13.8889	1.78	No	No	0	9	5
63	R:R:Q242	R:R:S264	12.3691	7.22	Yes	No	0	1	5
64	R:R:F244	R:R:W243	19.9808	6.01	Yes	Yes	1	5	4
65	R:R:F78	R:R:M109	32.8416	6.22	Yes	No	0	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K3	R:R:C168	4.85	1	Yes	No	0	6	0	1
L:L:K3	R:R:C180	3.23	1	Yes	Yes	0	9	0	1
L:L:K3	R:R:D184	8.3	1	Yes	Yes	0	3	0	1
L:L:K3	R:R:W243	9.28	1	Yes	Yes	0	4	0	1
L:L:K3	R:R:F244	2.48	1	Yes	Yes	0	5	0	1
L:L:K3	R:R:W248	3.48	1	Yes	Yes	0	3	0	1
L:L:N4	R:R:W243	5.65	0	No	Yes	0	4	0	1
L:L:N4	R:R:F257	3.62	0	No	No	0	3	0	1
L:L:F5	R:R:S103	10.57	3	No	No	0	5	0	1
L:L:F5	R:R:F170	9.65	3	No	Yes	0	3	0	1
L:L:F6	R:R:N85	6.04	0	Yes	No	0	4	0	1
L:L:F6	R:R:T106	7.78	0	Yes	Yes	0	5	0	1
L:L:F6	R:R:M109	4.98	0	Yes	No	0	4	0	1
L:L:F6	R:R:H261	5.66	0	Yes	Yes	0	2	0	1
L:L:W7	R:R:N85	11.3	0	No	No	0	4	0	1
L:L:W7	R:R:F105	28.06	0	No	Yes	0	5	0	1
L:L:W7	R:R:T106	6.06	0	No	Yes	0	5	0	1
L:L:K8	R:R:Y89	4.78	0	No	Yes	0	2	0	1
R:R:L31	R:R:Y89	4.69	0	No	Yes	3	2	2	1
R:R:V34	R:R:Y89	8.83	0	No	Yes	4	2	2	1
R:R:F78	R:R:M109	6.22	0	Yes	No	6	4	2	1
R:R:F105	R:R:F81	35.37	0	Yes	No	5	5	1	2
R:R:F105	R:R:I84	8.79	0	Yes	No	5	5	1	2
R:R:L90	R:R:Y89	3.52	0	No	Yes	4	2	2	1
R:R:F93	R:R:Y89	3.09	0	No	Yes	1	2	2	1
R:R:S103	R:R:T106	4.8	3	No	Yes	5	5	1	1
R:R:F170	R:R:S103	7.93	3	Yes	No	3	5	1	1
R:R:F105	R:R:M109	3.73	0	Yes	No	5	4	1	1
R:R:F170	R:R:T106	3.89	3	Yes	Yes	3	5	1	1
R:R:E164	R:R:G165	3.27	1	Yes	No	4	3	2	2
R:R:D184	R:R:E164	7.8	1	Yes	Yes	3	4	1	2
R:R:E164	R:R:F244	7	1	Yes	Yes	4	5	2	1
R:R:F170	R:R:G165	3.01	3	Yes	No	3	3	1	2
R:R:C168	R:R:C180	7.28	1	No	Yes	6	9	1	1
R:R:C180	R:R:D184	4.67	1	Yes	Yes	9	3	1	1
R:R:C180	R:R:W248	2.61	1	Yes	Yes	9	3	1	1
R:R:Q181	R:R:W248	10.95	0	No	Yes	3	3	2	1
R:R:D184	R:R:F244	9.55	1	Yes	Yes	3	5	1	1
R:R:D184	R:R:W248	6.7	1	Yes	Yes	3	3	1	1
R:R:F244	R:R:T187	3.89	1	Yes	No	5	4	1	2
R:R:F244	R:R:G240	3.01	1	Yes	No	5	7	1	2
R:R:F244	R:R:W243	6.01	1	Yes	Yes	5	4	1	1
R:R:L247	R:R:W243	3.42	0	No	Yes	3	4	2	1
R:R:F257	R:R:H261	16.97	0	No	Yes	3	2	1	1
R:R:H261	R:R:P262	3.05	0	Yes	No	2	1	1	2
R:R:H261	R:R:V265	4.15	0	Yes	Yes	2	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7S8L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	237
Number of Links	257
Number of Hubs	34
Number of Links mediated by Hubs	125
Number of Communities	9
Number of Nodes involved in Communities	35
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	30001
Length Of Smallest Path	3
Average Path Length	13.8271
Length of Longest Path	32
Minimum Path Strength	1.295
Average Path Strength	4.93314
Maximum Path Strength	23.3267
Minimum Path Correlation	0.7
Average Path Correlation	0.914844
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	45.6495
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.28
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • sleep • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cellular process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • establishment of organelle localization • regulated exocytosis • cellular localization • response to stimulus • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • system process • sensory perception • nervous system process • sensory perception of pain • cellular anatomical structure • membrane • cell periphery • plasma membrane • molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • G protein-coupled receptor binding • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • extracellular region • extracellular space • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7S8L_nogp_Chain_R K E T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	10.1038/s41586-021-04077-y
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	10.1038/s41586-021-04077-y
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	10.1038/s41586-021-04126-6
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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