psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F35	R:R:L31	8.53	No	No	0	4	3
2	R:R:F93	R:R:L31	7.31	No	No	0	1	3
3	R:R:I32	R:R:P33	3.39	No	No	0	5	4
4	R:R:P262	R:R:P33	3.9	No	No	0	1	4
5	R:R:V34	R:R:Y89	7.57	No	No	0	4	2
6	R:R:F35	R:R:L90	6.09	No	No	0	4	4
7	R:R:I37	R:R:Q82	4.12	Yes	Yes	1	6	5
8	R:R:I37	R:R:V265	4.61	Yes	No	1	6	4
9	R:R:I37	R:R:S269	4.64	Yes	No	0	6	5
10	R:R:C86	R:R:L38	4.76	No	No	0	5	5
11	R:R:I40	R:R:S269	4.64	No	No	0	7	5
12	R:R:I40	R:R:L270	4.28	No	No	0	7	6
13	R:R:I40	R:R:S273	4.64	No	No	0	7	8
14	R:R:A41	R:R:L79	6.3	No	Yes	0	5	7
15	R:R:A41	R:R:I83	3.25	No	No	0	5	6
16	R:R:G44	R:R:S273	3.71	No	No	0	9	8
17	R:R:F76	R:R:L45	7.31	Yes	No	5	7	7
18	R:R:C80	R:R:L45	3.17	No	No	5	4	7
19	R:R:A72	R:R:N48	3.13	No	No	0	9	9
20	R:R:D75	R:R:N48	16.16	No	No	1	9	9
21	R:R:N48	R:R:P276	13.03	No	No	1	9	9
22	R:R:A72	R:R:V51	3.39	No	No	0	9	9
23	R:R:F280	R:R:V51	6.55	Yes	No	2	8	9
24	R:R:F281	R:R:V51	3.93	Yes	No	2	6	9
25	R:R:F76	R:R:L52	3.65	Yes	No	0	7	8
26	R:R:L54	R:R:W53	5.69	Yes	No	2	8	6
27	R:R:F57	R:R:W53	7.02	No	No	2	5	6
28	R:R:R58	R:R:W53	5	No	No	2	5	6
29	R:R:L54	R:R:M59	8.48	Yes	No	2	8	6
30	R:R:F280	R:R:L54	3.65	Yes	Yes	2	8	8
31	R:R:F285	R:R:L54	3.65	Yes	Yes	2	6	8
32	R:R:L55	R:R:S65	6.01	No	No	0	8	8
33	R:R:F280	R:R:L55	7.31	Yes	No	0	8	8
34	R:R:F57	R:R:R58	3.21	No	No	2	5	5
35	R:R:F280	R:R:M59	4.98	Yes	No	2	8	6
36	R:R:F285	R:R:M59	3.73	Yes	No	2	6	6
37	R:R:N62	R:R:S65	4.47	No	No	0	8	8
38	R:R:F64	R:R:V68	3.93	No	No	0	7	8
39	R:R:F64	R:R:V123	7.87	No	No	3	7	9
40	R:R:F64	R:R:R127	3.21	No	No	3	7	9
41	R:R:S146	R:R:V66	9.7	No	No	0	9	6
42	R:R:T122	R:R:Y67	7.49	No	Yes	4	7	7
43	R:R:E126	R:R:Y67	11.22	No	Yes	4	9	7
44	R:R:S146	R:R:Y67	12.72	No	Yes	0	9	7
45	R:R:V149	R:R:Y67	7.57	No	Yes	4	6	7
46	R:R:M119	R:R:S70	9.2	No	No	0	6	9
47	R:R:C150	R:R:S70	5.16	No	No	0	7	9
48	R:R:S70	R:R:W154	3.71	No	Yes	0	9	9
49	R:R:L71	R:R:M119	5.65	No	No	0	9	6
50	R:R:L120	R:R:L71	5.54	Yes	No	3	9	9
51	R:R:L71	R:R:N275	10.98	No	Yes	3	9	9
52	R:R:A74	R:R:W154	3.89	No	Yes	0	9	9
53	R:R:D75	R:R:S272	5.89	No	No	1	9	9
54	R:R:D75	R:R:P276	4.83	No	No	1	9	9
55	R:R:C80	R:R:F76	4.19	No	Yes	5	4	7
56	R:R:F78	R:R:L79	3.65	Yes	Yes	1	6	7
57	R:R:F78	R:R:Q82	9.37	Yes	Yes	1	6	5
58	R:R:F78	R:R:M109	4.98	Yes	Yes	1	6	4
59	R:R:F78	R:R:Y113	7.22	Yes	Yes	1	6	8
60	R:R:F78	R:R:S268	6.61	Yes	No	1	6	8
61	R:R:F78	R:R:S272	5.28	Yes	No	1	6	9
62	R:R:L79	R:R:S269	6.01	Yes	No	0	7	5
63	R:R:L79	R:R:S272	6.01	Yes	No	1	7	9
64	R:R:F81	R:R:I84	6.28	No	No	0	5	5
65	R:R:F81	R:R:V108	6.55	No	No	0	5	6
66	R:R:F81	R:R:M109	6.22	No	Yes	0	5	4
67	R:R:M109	R:R:Q82	4.08	Yes	Yes	1	4	5
68	R:R:Q82	R:R:V265	4.3	Yes	No	1	5	4
69	R:R:F101	R:R:N85	3.62	No	No	0	4	4
70	R:R:C95	R:R:I97	6.55	No	No	0	4	5
71	R:R:F104	R:R:P102	4.33	No	No	6	4	5
72	R:R:F105	R:R:P102	18.78	No	No	6	5	5
73	R:R:F104	R:R:F105	9.65	No	No	6	4	5
74	R:R:F170	R:R:T106	5.19	No	No	0	3	5
75	R:R:L171	R:R:T107	5.9	No	No	0	1	4
76	R:R:F239	R:R:M109	3.73	Yes	Yes	1	6	4
77	R:R:S161	R:R:T110	6.4	No	No	0	7	2
78	R:R:C111	R:R:L158	4.76	No	No	0	5	4
79	R:R:C111	R:R:S161	3.44	No	No	0	5	7
80	R:R:L114	R:R:Y113	3.52	No	Yes	0	6	8
81	R:R:L117	R:R:Y113	7.03	No	Yes	0	8	8
82	R:R:F239	R:R:Y113	12.38	Yes	Yes	1	6	8
83	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
84	R:R:S268	R:R:Y113	5.09	No	Yes	1	8	8
85	R:R:A115	R:R:W154	11.67	No	Yes	0	7	9
86	R:R:A115	R:R:S157	3.42	No	No	0	7	8
87	R:R:F232	R:R:L117	6.09	Yes	No	0	9	8
88	R:R:L153	R:R:S118	9.01	No	No	0	7	8
89	R:R:L194	R:R:S118	4.5	No	No	0	8	8
90	R:R:L153	R:R:M119	4.24	No	No	0	7	6
91	R:R:F232	R:R:L120	6.09	Yes	Yes	0	9	9
92	R:R:L120	R:R:N271	4.12	Yes	Yes	3	9	9
93	R:R:L120	R:R:N275	9.61	Yes	Yes	3	9	9
94	R:R:L120	R:R:Y279	8.21	Yes	Yes	3	9	9
95	R:R:L194	R:R:S121	4.5	No	No	0	8	7
96	R:R:S121	R:R:V197	3.23	No	No	0	7	6
97	R:R:T122	R:R:V149	4.76	No	No	4	7	6
98	R:R:L153	R:R:T122	4.42	No	No	0	7	7
99	R:R:R127	R:R:V123	5.23	No	No	3	9	9
100	R:R:V123	R:R:Y279	3.79	No	Yes	3	9	9
101	R:R:L198	R:R:S124	4.5	No	No	0	8	9
102	R:R:S124	R:R:S201	4.89	No	No	0	9	8
103	R:R:S124	R:R:S202	3.26	No	No	0	9	8
104	R:R:S201	R:R:T125	6.4	No	No	0	8	7
105	R:R:E126	R:R:Y137	4.49	No	No	4	9	7
106	R:R:E126	R:R:R141	8.14	No	Yes	4	9	8
107	R:R:R127	R:R:Y279	4.12	No	Yes	3	9	9
108	R:R:C128	R:R:L132	3.17	No	No	0	8	6
109	R:R:C128	R:R:S201	5.16	No	No	0	8	8
110	R:R:S130	R:R:V131	3.23	No	No	0	8	8
111	R:R:S130	R:R:Y137	7.63	No	No	0	8	7
112	R:R:L205	R:R:V131	4.47	No	No	0	8	8
113	R:R:I209	R:R:V131	4.61	No	No	0	6	8
114	R:R:L132	R:R:R208	6.07	No	No	0	6	7
115	R:R:W133	R:R:W136	7.5	No	No	0	5	6
116	R:R:R140	R:R:W136	4	No	No	0	6	6
117	R:R:R141	R:R:Y137	10.29	Yes	No	4	8	7
118	R:R:C139	R:R:R138	4.18	No	No	0	7	7
119	R:R:L145	R:R:R141	9.72	No	Yes	0	5	8
120	R:R:L145	R:R:P142	4.93	No	No	0	5	7
121	R:R:H144	R:R:R143	9.03	No	No	0	5	5
122	R:R:L156	R:R:W190	5.69	No	No	0	6	7
123	R:R:L160	R:R:T187	4.42	No	No	0	4	4
124	R:R:F183	R:R:L163	6.09	Yes	No	0	4	8
125	R:R:E164	R:R:G165	3.27	No	No	0	4	3
126	R:R:C168	R:R:E164	6.08	No	No	0	6	4
127	R:R:G165	R:R:L171	5.13	No	No	0	3	1
128	R:R:F167	R:R:K166	3.72	No	No	0	4	3
129	R:R:F172	R:R:K166	11.17	No	No	0	1	3
130	R:R:F167	R:R:W179	5.01	No	No	8	4	2
131	R:R:F167	R:R:F183	4.29	No	Yes	8	4	4
132	R:R:C168	R:R:C180	7.28	No	No	0	6	9
133	R:R:D174	R:R:G175	3.35	No	No	0	2	3
134	R:R:D176	R:R:W179	3.35	No	No	0	3	2
135	R:R:F183	R:R:W179	9.02	Yes	No	8	4	2
136	R:R:Q181	R:R:T182	5.67	No	No	0	3	2
137	R:R:F185	R:R:Q181	9.37	No	No	9	3	3
138	R:R:Q181	R:R:W248	4.38	No	No	9	3	3
139	R:R:D184	R:R:T187	4.34	No	No	7	3	4
140	R:R:D184	R:R:F244	11.94	No	No	7	3	5
141	R:R:F185	R:R:L245	7.31	No	No	0	3	5
142	R:R:F185	R:R:W248	4.01	No	No	9	3	3
143	R:R:F244	R:R:T187	11.67	No	No	7	5	4
144	R:R:A188	R:R:L245	4.73	No	No	0	5	5
145	R:R:L194	R:R:W190	14.81	No	No	0	8	7
146	R:R:F193	R:R:M196	3.73	No	No	0	5	5
147	R:R:F193	R:R:V197	5.24	No	No	0	5	6
148	R:R:C199	R:R:F195	8.38	No	Yes	0	5	6
149	R:R:F195	R:R:F232	8.57	Yes	Yes	0	6	9
150	R:R:F195	R:R:L233	4.87	Yes	No	0	6	7
151	R:R:F195	R:R:L237	6.09	Yes	No	0	6	6
152	R:R:L198	R:R:V229	5.96	No	No	0	8	8
153	R:R:F232	R:R:L198	6.09	Yes	No	0	9	8
154	R:R:S202	R:R:V229	3.23	No	No	0	8	8
155	R:R:I225	R:R:L205	4.28	No	No	0	7	8
156	R:R:L206	R:R:Y222	7.03	No	No	0	5	6
157	R:R:I225	R:R:L206	7.14	No	No	0	7	5
158	R:R:I209	R:R:S213	4.64	No	No	0	6	7
159	R:R:I209	R:R:L221	4.28	No	No	0	6	8
160	R:R:L210	R:R:L218	5.54	No	No	0	5	7
161	R:R:L216	R:R:S213	4.5	No	No	0	4	7
162	R:R:L216	R:R:P217	3.28	No	No	0	4	5
163	R:R:R220	R:R:R286	8.53	No	No	0	8	7
164	R:R:I225	R:R:L221	4.28	No	No	0	7	8
165	R:R:L226	R:R:Y222	4.69	No	No	0	5	6
166	R:R:I278	R:R:L227	4.28	Yes	No	0	8	7
167	R:R:T228	R:R:Y279	4.99	No	Yes	0	7	9
168	R:R:I278	R:R:V231	4.61	Yes	No	0	8	7
169	R:R:C235	R:R:N271	3.15	No	Yes	0	7	9
170	R:R:G236	R:R:N271	5.09	No	Yes	0	7	9
171	R:R:F239	R:R:Q242	4.68	Yes	Yes	0	6	1
172	R:R:F239	R:R:V265	6.55	Yes	No	1	6	4
173	R:R:F239	R:R:S268	7.93	Yes	No	1	6	8
174	R:R:H261	R:R:Q242	11.13	Yes	Yes	0	2	1
175	R:R:Q242	R:R:S264	10.11	Yes	No	0	1	5
176	R:R:F244	R:R:W243	4.01	No	No	0	5	4
177	R:R:H261	R:R:W243	8.46	Yes	No	0	2	4
178	R:R:I246	R:R:W250	8.22	No	Yes	0	4	1
179	R:R:D252	R:R:W250	5.58	No	Yes	0	1	1
180	R:R:D254	R:R:V255	4.38	No	No	0	1	1
181	R:R:N271	R:R:N275	10.9	Yes	Yes	3	9	9
182	R:R:N275	R:R:Y279	3.49	Yes	Yes	3	9	9
183	R:R:I278	R:R:Y279	7.25	Yes	Yes	0	8	9
184	R:R:F280	R:R:F281	8.57	Yes	Yes	2	8	6
185	R:R:F280	R:R:F285	4.29	Yes	Yes	2	8	6
186	R:R:F281	R:R:F285	6.43	Yes	Yes	2	6	6
187	R:R:I37	R:R:V266	3.07	Yes	No	0	6	5
188	R:R:I99	R:R:V88	3.07	No	No	0	1	3
189	R:R:I162	R:R:T107	3.04	No	No	0	4	4
190	R:R:F76	R:R:G49	3.01	Yes	No	0	7	6
191	R:R:F57	R:R:G56	3.01	No	No	0	5	6
192	R:R:L114	R:R:S161	3	No	No	0	6	7
193	R:R:R141	R:R:W136	3	Yes	No	0	8	6
194	R:R:L218	R:R:S213	3	No	No	0	7	7
195	R:R:G215	R:R:R214	3	No	No	0	5	5
196	R:R:G283	R:R:R286	3	No	No	0	9	7
197	R:R:L90	R:R:V34	2.98	No	No	0	4	4
198	R:R:L203	R:R:V207	2.98	No	No	0	5	5
199	R:R:I97	R:R:I99	2.94	No	No	0	5	1
200	R:R:I192	R:R:I241	2.94	No	No	0	5	6
201	R:R:I241	R:R:I246	2.94	No	No	0	6	4
202	R:R:I83	R:R:L42	2.85	No	No	0	6	5
203	R:R:I83	R:R:L45	2.85	No	No	0	6	7
204	R:R:I162	R:R:L158	2.85	No	No	0	4	4
205	R:R:I241	R:R:L237	2.85	No	No	0	6	6
206	R:R:A63	R:R:R141	2.77	No	Yes	0	7	8
207	R:R:L114	R:R:L191	2.77	No	No	0	6	7
208	R:R:R61	R:R:S65	2.64	No	No	0	7	8
209	R:R:F39	R:R:V43	2.62	No	No	0	5	5
210	R:R:F183	R:R:T182	2.59	Yes	No	0	4	2
211	R:R:F105	R:R:I84	2.51	No	No	0	5	5
212	R:R:T30	R:R:Y89	2.5	No	No	0	3	2
213	R:R:S177	R:R:W248	2.47	No	No	0	3	3
214	R:R:S253	R:R:W250	2.47	No	Yes	0	1	1
215	R:R:L69	R:R:R61	2.43	No	No	0	7	7
216	R:R:T106	R:R:W243	2.43	No	No	0	5	4
217	R:R:F101	R:R:N100	2.42	No	No	0	4	1
218	R:R:I249	R:R:W250	2.35	No	Yes	0	1	1
219	R:R:L223	R:R:Y222	2.34	No	No	0	6	6
220	R:R:L77	R:R:W154	2.28	No	Yes	0	6	9
221	R:R:F257	R:R:H261	2.26	No	Yes	0	3	2
222	R:R:G169	R:R:G175	2.11	No	No	0	1	3
223	R:R:G236	R:R:P238	2.03	No	No	0	7	9
224	R:R:C199	R:R:G200	1.96	No	No	0	5	4
225	R:R:C211	R:R:G212	1.96	No	No	0	5	5
226	R:R:A74	R:R:G116	1.95	No	No	0	9	9
227	R:R:G283	R:R:V282	1.84	No	No	0	9	7
228	R:R:A204	R:R:C128	1.81	No	No	0	6	8
229	R:R:C86	R:R:V34	1.71	No	No	0	5	4
230	R:R:G73	R:R:L52	1.71	No	No	0	5	8
231	R:R:G215	R:R:L216	1.71	No	No	0	5	4
232	R:R:C258	R:R:T30	1.69	No	No	0	1	3
233	R:R:D176	R:R:G175	1.68	No	No	0	3	3
234	R:R:C86	R:R:I37	1.64	No	Yes	0	5	6
235	R:R:L267	R:R:P238	1.64	No	No	0	7	9
236	R:R:A274	R:R:I278	1.62	No	Yes	0	7	8
237	R:R:C235	R:R:L234	1.59	No	No	0	7	5
238	R:R:A112	R:R:L77	1.58	No	No	0	7	6
239	R:R:I260	R:R:V263	1.54	No	No	0	3	5
240	R:R:H261	R:R:P262	1.53	Yes	No	0	2	1
241	R:R:F281	R:R:G47	1.51	Yes	No	0	6	8
242	R:R:L36	R:R:V266	1.49	No	No	0	5	5
243	R:R:N92	R:R:S91	1.49	No	No	0	3	2
244	R:R:L152	R:R:V148	1.49	No	No	0	4	4
245	R:R:L256	R:R:V255	1.49	No	No	0	2	1
246	R:R:N85	R:R:V88	1.48	No	No	0	4	3
247	R:R:L129	R:R:T125	1.47	No	No	0	6	7
248	R:R:L223	R:R:T219	1.47	No	No	0	6	5
249	R:R:I249	R:R:K251	1.45	No	No	0	1	1
250	R:R:F101	R:R:P102	1.44	No	No	0	4	5
251	R:R:I260	R:R:L256	1.43	No	No	0	3	2
252	R:R:I99	R:R:N92	1.42	No	No	0	1	3
253	R:R:K166	R:R:L171	1.41	No	No	0	3	1
254	R:R:C95	R:R:F94	1.4	No	No	0	4	3
255	R:R:C139	R:R:R140	1.39	No	No	0	7	6
256	R:R:L159	R:R:L160	1.38	No	No	0	4	4
257	R:R:H259	R:R:V263	1.38	No	No	0	2	5
258	R:R:I260	R:R:Q242	1.37	No	Yes	0	3	1
259	R:R:P134	R:R:W133	1.35	No	No	0	9	5
260	R:R:L247	R:R:Q242	1.33	No	Yes	0	3	1
261	R:R:F285	R:R:S284	1.32	Yes	No	0	6	7
262	R:R:F183	R:R:I186	1.26	Yes	No	0	4	6
263	R:R:F281	R:R:I277	1.26	Yes	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I37	3.616	5	1	6
2	R:R:L54	5.3675	4	2	8
3	R:R:Y67	9.75	4	4	7
4	R:R:F76	4.54	4	5	7
5	R:R:F78	6.185	6	1	6
6	R:R:L79	5.4925	4	1	7
7	R:R:Q82	5.4675	4	1	5
8	R:R:M109	4.7525	4	1	4
9	R:R:Y113	6.59833	6	1	8
10	R:R:L120	6.714	5	3	9
11	R:R:R141	6.784	5	4	8
12	R:R:W154	5.3875	4	0	9
13	R:R:F183	4.65	5	8	4
14	R:R:F195	6.9775	4	0	6
15	R:R:F232	6.71	4	0	9
16	R:R:F239	7.054	5	1	6
17	R:R:Q242	5.724	5	0	1
18	R:R:W250	4.655	4	0	1
19	R:R:H261	5.845	4	0	2
20	R:R:N271	5.815	4	3	9
21	R:R:N275	8.745	4	3	9
22	R:R:I278	4.44	4	0	8
23	R:R:Y279	5.30833	6	3	9
24	R:R:F280	5.89167	6	2	8
25	R:R:F281	4.34	5	2	6
26	R:R:F285	3.884	5	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C86	R:R:V34	18.89	1.71	No	No	0	5	4
2	R:R:C86	R:R:I37	23.2765	1.64	No	Yes	0	5	6
3	R:R:I37	R:R:V265	13.4706	4.61	Yes	No	1	6	4
4	R:R:F239	R:R:V265	14.5097	6.55	Yes	No	1	6	4
5	R:R:F239	R:R:Q242	38.1098	4.68	Yes	Yes	0	6	1
6	R:R:H261	R:R:Q242	23.1272	11.13	Yes	Yes	0	2	1
7	R:R:I37	R:R:Q82	14.8519	4.12	Yes	Yes	1	6	5
8	R:R:A41	R:R:L79	14.9515	6.3	No	Yes	0	5	7
9	R:R:A41	R:R:I83	13.3213	3.25	No	No	0	5	6
10	R:R:I83	R:R:L45	10.0174	2.85	No	No	0	6	7
11	R:R:A72	R:R:N48	35.2725	3.13	No	No	0	9	9
12	R:R:D75	R:R:N48	36.6787	16.16	No	No	1	9	9
13	R:R:D75	R:R:S272	39.8644	5.89	No	No	1	9	9
14	R:R:F78	R:R:S272	37.0147	5.28	Yes	No	1	6	9
15	R:R:F78	R:R:Q82	14.1488	9.37	Yes	Yes	1	6	5
16	R:R:A72	R:R:V51	33.717	3.39	No	No	0	9	9
17	R:R:F280	R:R:V51	23.6872	6.55	Yes	No	2	8	9
18	R:R:F78	R:R:Y113	65.0759	7.22	Yes	Yes	1	6	8
19	R:R:L117	R:R:Y113	100	7.03	No	Yes	0	8	8
20	R:R:F232	R:R:L117	99.6329	6.09	Yes	No	0	9	8
21	R:R:F232	R:R:L120	85.8387	6.09	Yes	Yes	0	9	9
22	R:R:L120	R:R:Y279	17.938	8.21	Yes	Yes	3	9	9
23	R:R:F239	R:R:Y113	49.5893	12.38	Yes	Yes	1	6	8
24	R:R:L120	R:R:L71	69.562	5.54	Yes	No	3	9	9
25	R:R:L71	R:R:M119	74.9378	5.65	No	No	0	9	6
26	R:R:L153	R:R:M119	63.6137	4.24	No	No	0	7	6
27	R:R:L153	R:R:T122	52.3519	4.42	No	No	0	7	7
28	R:R:T122	R:R:Y67	49.5147	7.49	No	Yes	4	7	7
29	R:R:E126	R:R:Y67	45.5575	11.22	No	Yes	4	9	7
30	R:R:M119	R:R:S70	15.1692	9.2	No	No	0	6	9
31	R:R:S70	R:R:W154	11.884	3.71	No	Yes	0	9	9
32	R:R:F81	R:R:M109	35.0859	6.22	No	Yes	0	5	4
33	R:R:F81	R:R:I84	30.7989	6.28	No	No	0	5	5
34	R:R:F101	R:R:P102	22.3432	1.44	No	No	0	4	5
35	R:R:F105	R:R:P102	24.4711	18.78	No	No	6	5	5
36	R:R:F105	R:R:I84	28.6274	2.51	No	No	0	5	5
37	R:R:F101	R:R:N85	18.1994	3.62	No	No	0	4	4
38	R:R:I99	R:R:V88	13.732	3.07	No	No	0	1	3
39	R:R:N85	R:R:V88	15.9781	1.48	No	No	0	4	3
40	R:R:H261	R:R:W243	14.4599	8.46	Yes	No	0	2	4
41	R:R:L114	R:R:Y113	44.0767	3.52	No	Yes	0	6	8
42	R:R:L114	R:R:S161	41.563	3	No	No	0	6	7
43	R:R:C111	R:R:S161	39.1737	3.44	No	No	0	5	7
44	R:R:C111	R:R:L158	37.8733	4.76	No	No	0	5	4
45	R:R:I162	R:R:L158	36.5605	2.85	No	No	0	4	4
46	R:R:I162	R:R:T107	35.2352	3.04	No	No	0	4	4
47	R:R:L171	R:R:T107	33.8975	5.9	No	No	0	1	4
48	R:R:L153	R:R:S118	13.5329	9.01	No	No	0	7	8
49	R:R:L194	R:R:S118	11.884	4.5	No	No	0	8	8
50	R:R:F232	R:R:L198	18.3798	6.09	Yes	No	0	9	8
51	R:R:L198	R:R:S124	13.8191	4.5	No	No	0	8	9
52	R:R:S124	R:R:S201	10.8076	4.89	No	No	0	9	8
53	R:R:E126	R:R:Y137	28.9447	4.49	No	No	4	9	7
54	R:R:E126	R:R:R141	15.3435	8.14	No	Yes	4	9	8
55	R:R:S130	R:R:Y137	28.6772	7.63	No	No	0	8	7
56	R:R:S130	R:R:V131	27.1528	3.23	No	No	0	8	8
57	R:R:L205	R:R:V131	11.268	4.47	No	No	0	8	8
58	R:R:I209	R:R:V131	14.4102	4.61	No	No	0	6	8
59	R:R:R141	R:R:W136	10.2227	3	Yes	No	0	8	6
60	R:R:F167	R:R:F183	15.051	4.29	No	Yes	8	4	4
61	R:R:F167	R:R:K166	24.1849	3.72	No	No	0	4	3
62	R:R:K166	R:R:L171	27.0222	1.41	No	No	0	3	1
63	R:R:F183	R:R:T182	10.9445	2.59	Yes	No	0	4	2
64	R:R:F195	R:R:F232	20.1344	8.57	Yes	Yes	0	6	9
65	R:R:F195	R:R:L237	14.1613	6.09	Yes	No	0	6	6
66	R:R:I209	R:R:S213	11.7409	4.64	No	No	0	6	7
67	R:R:I241	R:R:L237	12.6369	2.85	No	No	0	6	6
68	R:R:I260	R:R:Q242	10.9756	1.37	No	Yes	0	3	1
69	R:R:F239	R:R:M109	21.889	3.73	Yes	Yes	1	6	4
70	R:R:F78	R:R:L79	18.6287	3.65	Yes	Yes	1	6	7
71	R:R:F78	R:R:M109	23.6063	4.98	Yes	Yes	1	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7VUY_nogp

PDB Summary
PDB	7VUY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.13
Number of Linked Nodes	241
Number of Links	263
Number of Hubs	26
Number of Links mediated by Hubs	97
Number of Communities	9
Number of Nodes involved in Communities	51
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	33334
Length Of Smallest Path	3
Average Path Length	13.9991
Length of Longest Path	34
Minimum Path Strength	1.35
Average Path Strength	5.60219
Maximum Path Strength	11.97
Minimum Path Correlation	0.7
Average Path Correlation	0.917295
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	50.5561
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.7761
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • sleep • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cellular process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • establishment of organelle localization • regulated exocytosis • cellular localization • response to stimulus • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • system process • sensory perception • nervous system process • sensory perception of pain • cellular anatomical structure • membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cellular component organization or biogenesis • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7VUY_nogp_Chain_R T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G S R G L P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W K D S D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F R K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VUY_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.