Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:K3 8.13167610
2L:L:F6 6.476510
3R:R:L55 5.2675408
4R:R:Y67 6.205627
5R:R:F78 4.66516
6R:R:L79 5.4325417
7R:R:I83 2.9525406
8R:R:F101 5.9325444
9R:R:Y113 5.68418
10R:R:W136 3.82426
11R:R:Y137 7.385427
12R:R:R141 5.72333628
13R:R:E164 6.98414
14R:R:F170 5.082513
15R:R:C180 5.4275419
16R:R:D184 7.598513
17R:R:W190 5.525407
18R:R:L198 4.14408
19R:R:I209 3.8225406
20R:R:F232 6.888509
21R:R:F239 5.786516
22R:R:Q242 8.6525401
23R:R:W243 8.29667614
24R:R:F244 8.332515
25R:R:W248 9.2775413
26R:R:H261 8.356512
27R:R:N271 5.5525409
28R:R:N275 6.585439
29R:R:Y279 5.68639
30R:R:F280 4.954508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:K3 R:R:W243 15.90522.05YesYes104
2R:R:H261 R:R:W243 31.40737.41YesYes124
3R:R:H261 R:R:P262 17.37921.53YesNo021
4R:R:P262 R:R:P33 15.89933.9NoNo014
5R:R:I32 R:R:P33 10.29716.77NoNo054
6R:R:C86 R:R:V34 15.14523.42NoNo054
7R:R:V34 R:R:Y89 13.793.79NoNo042
8R:R:F239 R:R:W243 41.21125.01YesYes164
9R:R:F239 R:R:F78 13.2573.22YesYes166
10R:R:F78 R:R:Q82 13.56889.37YesNo065
11R:R:Q82 R:R:V265 11.66364.3NoNo054
12R:R:F78 R:R:S272 41.57412.64YesNo169
13R:R:L79 R:R:S272 34.50910.51YesNo179
14R:R:L45 R:R:L79 28.2324.15NoYes077
15R:R:I83 R:R:L45 23.10614.28YesNo067
16R:R:I83 R:R:L42 18.26381.43YesNo065
17R:R:L38 R:R:L42 14.89572.77NoNo055
18R:R:F239 R:R:Y113 32.70588.25YesYes168
19R:R:L117 R:R:Y113 99.51247.03NoYes088
20R:R:F232 R:R:L117 1009.74YesNo098
21R:R:F232 R:R:L120 50.86198.53YesNo099
22R:R:L120 R:R:Y279 39.16999.38NoYes399
23R:R:R127 R:R:Y279 33.11413.09NoYes099
24R:R:R127 R:R:V123 32.02546.54NoNo099
25R:R:F64 R:R:V123 30.77237.87NoNo079
26R:R:F64 R:R:N62 29.64393.62NoNo078
27R:R:N62 R:R:S65 28.34544.47NoNo088
28R:R:L55 R:R:S65 27.03563YesNo088
29R:R:F280 R:R:L55 21.68299.74YesYes088
30R:R:F280 R:R:F281 10.43323.22YesNo086
31R:R:F232 R:R:L198 95.71336.09YesYes098
32R:R:L198 R:R:S121 68.21843YesNo087
33R:R:L194 R:R:S121 67.32256.01NoNo087
34R:R:L194 R:R:S118 44.87413NoNo088
35R:R:L153 R:R:S118 43.71747.51NoNo078
36R:R:L153 R:R:T122 29.04854.42NoNo077
37R:R:T122 R:R:Y67 26.45167.49NoYes277
38R:R:R141 R:R:Y67 19.6533.09YesYes287
39R:R:L153 R:R:M119 13.60295.65NoNo076
40R:R:M119 R:R:S70 10.92657.67NoNo269
41R:R:S70 R:R:W154 10.51266.18NoNo099
42R:R:L120 R:R:N275 10.56366.87NoYes399
43L:L:F6 R:R:M109 10.25186.22YesNo004
44R:R:F81 R:R:M109 12.20238.71NoNo054
45R:R:F81 R:R:V108 10.65435.24NoNo056
46R:R:N92 R:R:Y89 12.42353.49NoNo032
47R:R:L194 R:R:W190 29.57597.97NoYes087
48R:R:L160 R:R:W190 24.29124.56NoYes047
49R:R:L159 R:R:L160 21.7682.77NoNo044
50R:R:L159 R:R:L163 20.39584.15NoNo048
51R:R:F183 R:R:L163 19.01229.74NoNo048
52R:R:F183 R:R:W179 16.21126.01NoNo042
53R:R:F167 R:R:W179 13.364710.02NoNo042
54R:R:F167 R:R:K166 11.92456.2NoNo043
55R:R:E164 R:R:T110 10.71674.23YesNo042
56R:R:C111 R:R:S161 11.40853.44NoNo057
57R:R:F244 R:R:T187 16.602412.97YesNo054
58R:R:L114 R:R:T187 14.86734.42NoNo064
59R:R:D184 R:R:F244 10.98897.17YesYes135
60R:R:C111 R:R:L158 10.86986.35NoNo054
61R:R:F244 R:R:G240 28.57793.01YesNo157
62R:R:L198 R:R:S124 31.66253YesNo089
63R:R:S124 R:R:S202 22.21593.26NoNo098
64R:R:I225 R:R:S202 41.13743.1NoNo078
65R:R:I225 R:R:L205 36.27814.28NoNo078
66R:R:L198 R:R:V229 22.64124.47YesNo088
67R:R:S202 R:R:V229 21.41643.23NoNo088
68R:R:D184 R:R:W248 10.682710.05YesYes133
69R:R:H261 R:R:Q242 16.778213.6YesYes021
70R:R:I246 R:R:Q242 10.20074.12NoYes041
71R:R:F195 R:R:F232 16.21126.43NoYes069
72R:R:I209 R:R:L205 28.75944.28YesNo068
73R:R:I209 R:R:S213 15.53643.1YesNo067
74R:R:L216 R:R:S213 10.54661.5NoNo047
75R:R:G240 R:R:Y113 25.82794.35NoYes178
76R:R:F78 R:R:Y113 47.71493.09YesYes168
77R:R:F78 R:R:M109 16.34724.98YesNo064
78R:R:C86 R:R:L38 13.39874.76NoNo055
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K3 R:R:E164 5.4 1 Yes Yes 0 4 0 1
L:L:K3 R:R:C168 4.85 1 Yes No 0 6 0 1
L:L:K3 R:R:F170 4.96 1 Yes Yes 0 3 0 1
L:L:K3 R:R:C180 3.23 1 Yes Yes 0 9 0 1
L:L:K3 R:R:D184 8.3 1 Yes Yes 0 3 0 1
L:L:K3 R:R:W243 22.05 1 Yes Yes 0 4 0 1
L:L:N4 R:R:F257 7.25 0 No No 0 3 0 1
L:L:F5 R:R:T106 9.08 0 No No 0 5 0 1
L:L:F6 R:R:N85 4.83 1 Yes No 0 4 0 1
L:L:F6 R:R:M109 6.22 1 Yes No 0 4 0 1
L:L:F6 R:R:W243 5.01 1 Yes Yes 0 4 0 1
L:L:F6 R:R:H261 4.53 1 Yes Yes 0 2 0 1
R:R:F78 R:R:M109 4.98 1 Yes No 6 4 2 1
R:R:F239 R:R:F78 3.22 1 Yes Yes 6 6 2 2
R:R:F81 R:R:M109 8.71 0 No No 5 4 2 1
R:R:F170 R:R:S103 3.96 1 Yes No 3 5 1 2
R:R:F170 R:R:T106 7.78 1 Yes No 3 5 1 1
R:R:E164 R:R:T110 4.23 1 Yes No 4 2 1 2
R:R:D184 R:R:E164 7.8 1 Yes Yes 3 4 1 1
R:R:E164 R:R:F244 10.49 1 Yes Yes 4 5 1 2
R:R:F170 R:R:G165 4.52 1 Yes No 3 3 1 2
R:R:C168 R:R:F170 4.19 1 No Yes 6 3 1 1
R:R:C168 R:R:C180 7.28 1 No Yes 6 9 1 1
R:R:C180 R:R:D184 4.67 1 Yes Yes 9 3 1 1
R:R:C180 R:R:W248 6.53 1 Yes Yes 9 3 1 2
R:R:D184 R:R:F244 7.17 1 Yes Yes 3 5 1 2
R:R:D184 R:R:W248 10.05 1 Yes Yes 3 3 1 2
R:R:F239 R:R:W243 5.01 1 Yes Yes 6 4 2 1
R:R:H261 R:R:Q242 13.6 1 Yes Yes 2 1 1 2
R:R:F244 R:R:W243 8.02 1 Yes Yes 5 4 2 1
R:R:H261 R:R:W243 7.41 1 Yes Yes 2 4 1 1
R:R:F257 R:R:H261 14.71 0 No Yes 3 2 1 1
R:R:L247 R:R:W243 2.28 0 No Yes 3 4 2 1
R:R:G169 R:R:G175 2.11 0 No No 1 3 1 2
L:L:C2 R:R:G169 1.96 0 No No 0 1 0 1
R:R:H261 R:R:P262 1.53 1 Yes No 2 1 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7S8M_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3
Number of Linked Nodes 241
Number of Links 266
Number of Hubs 30
Number of Links mediated by Hubs 111
Number of Communities 4
Number of Nodes involved in Communities 35
Number of Links involved in Communities 51
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 37401
Length Of Smallest Path 3
Average Path Length 13.5634
Length of Longest Path 33
Minimum Path Strength 1.155
Average Path Strength 5.70168
Maximum Path Strength 15.035
Minimum Path Correlation 0.7
Average Path Correlation 0.923804
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 51.0353
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.8825
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • neuropeptide binding   • peptide binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • mast cell secretagogue receptor activity   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • sleep   • regulation of cytokinesis   • positive regulation of cell division   • regulation of cell cycle process   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • establishment of organelle localization   • regulated exocytosis   • cellular localization   • transport   • cell activation involved in immune response   • leukocyte degranulation   • myeloid leukocyte activation   • myeloid leukocyte mediated immunity   • vesicle-mediated transport   • leukocyte activation   • localization   • secretion by cell   • organelle localization   • leukocyte activation involved in immune response   • establishment of localization in cell   • mast cell activation   • leukocyte mediated immunity   • mast cell mediated immunity   • immune response   • secretion   • cell activation   • vacuolar localization   • export from cell   • mast cell degranulation   • establishment of localization   • myeloid cell activation involved in immune response   • immune effector process   • mast cell activation involved in immune response   • exocytosis   • immune system process   • lysosome localization   • sensory perception of pain   • periplasmic space   • molecular function activator activity   • signaling receptor binding   • neuropeptide activity   • signaling receptor activator activity   • hormone activity   • molecular function regulator activity   • neuropeptide hormone activity   • signaling receptor regulator activity   • receptor ligand activity   • G protein-coupled receptor binding   • regulation of cell motility   • regulation of locomotion   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • trans-synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ96LB1
Sequence
>7S8M_nogp_Chain_R
KETLIPVFL ILFIALVGL VGNGFVLWL LGFRMRRNA FSVYVLSLA 
GADFLFLCF QIINCLVYL SNFFCSISI NFPSFFTTV MTCAYLAGL 
SMLSTVSTE RCLSVLWPI WYRCRRPRH LSAVVCVLL WALSLLLSI 
LEGKFCGFL FSDGDSGWC QTFDFITAA WLIFLFMVL CGSSLALLV 
RILCGSRGL PLTRLYLTI LLTVLVFLL CGLPFGIQW FLILWIWLF 
CHIHPVSVV LSSLNSSAN PIIYFFVGS F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VV6AOrphanOrphanMRGPRX2Homo sapiensC48/80--3.32021-12-0110.1038/s41586-021-04077-y
7VV4AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14--2.972021-12-0110.1038/s41586-021-04077-y
7VV0AOrphanOrphanMRGPRX2Homo sapiensPAMP-12--3.52021-12-0110.1038/s41586-021-04077-y
7VV5AOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.762021-12-0110.1038/s41586-021-04077-y
7VV5 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.762021-12-0110.1038/s41586-021-04077-y
7VV3AOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.972021-12-0110.1038/s41586-021-04077-y
7VV3 (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.972021-12-0110.1038/s41586-021-04077-y
7VUZAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.892021-12-0110.1038/s41586-021-04077-y
7VUZ (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.892021-12-0110.1038/s41586-021-04077-y
7VUYAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.842021-12-0110.1038/s41586-021-04077-y
7VUY (No Gprot) AOrphanOrphanMRGPRX2Homo sapiens--2.842021-12-0110.1038/s41586-021-04077-y
7VDMAOrphanOrphanMRGPRX2Homo sapiensSubstance-P-Gi1/β1/γ22.982021-12-0110.1038/s41586-021-04077-y
7VDM (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensSubstance-P-2.982021-12-0110.1038/s41586-021-04077-y
7VDLAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ23.222021-12-0110.1038/s41586-021-04077-y
7VDL (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-3.222021-12-0110.1038/s41586-021-04077-y
7VDHAOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.92021-12-0110.1038/s41586-021-04077-y
7VDH (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensC48/80-2.92021-12-0110.1038/s41586-021-04077-y
7S8NAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ22.92021-11-1710.1038/s41586-021-04126-6
7S8N (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.92021-11-1710.1038/s41586-021-04126-6
7S8LAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ22.452021-11-1710.1038/s41586-021-04126-6
7S8L (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.452021-11-1710.1038/s41586-021-04126-6
7S8OAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-Gi1/β1/γ22.582021-11-1710.1038/s41586-021-04126-6
7S8O (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-2.582021-11-1710.1038/s41586-021-04126-6
7S8MAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ22.542021-11-1710.1038/s41586-021-04126-6
7S8M (No Gprot) AOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-2.542021-11-1710.1038/s41586-021-04126-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7S8M_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.