psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T30	R:R:Y89	8.74	No	Yes	0	3	2
2	R:R:F35	R:R:L31	6.09	No	Yes	0	4	3
3	R:R:F93	R:R:L31	3.65	No	Yes	0	1	3
4	R:R:I32	R:R:P33	3.39	No	No	0	5	4
5	R:R:P262	R:R:P33	3.9	No	No	0	1	4
6	R:R:V34	R:R:Y89	5.05	No	Yes	0	4	2
7	R:R:C86	R:R:I37	3.27	No	No	0	5	6
8	R:R:I37	R:R:V265	4.61	No	No	0	6	4
9	R:R:I37	R:R:V266	4.61	No	No	0	6	5
10	R:R:I40	R:R:S269	3.1	Yes	No	0	7	5
11	R:R:I40	R:R:L270	5.71	Yes	No	0	7	6
12	R:R:I40	R:R:S273	3.1	Yes	No	0	7	8
13	R:R:A41	R:R:I83	3.25	No	No	0	5	6
14	R:R:G44	R:R:S273	3.71	No	No	0	9	8
15	R:R:F76	R:R:L45	8.53	No	No	0	7	7
16	R:R:I83	R:R:L45	4.28	No	No	0	6	7
17	R:R:D75	R:R:N48	12.12	No	No	0	9	9
18	R:R:N48	R:R:P276	8.15	No	No	0	9	9
19	R:R:A72	R:R:V51	3.39	No	No	0	9	9
20	R:R:F280	R:R:V51	10.49	Yes	No	4	8	9
21	R:R:F281	R:R:V51	3.93	Yes	No	4	6	9
22	R:R:A72	R:R:L52	3.15	No	Yes	0	9	8
23	R:R:G73	R:R:L52	3.42	No	Yes	0	5	8
24	R:R:F76	R:R:L52	4.87	No	Yes	0	7	8
25	R:R:L54	R:R:W53	5.69	No	No	0	8	6
26	R:R:F57	R:R:W53	6.01	No	No	0	5	6
27	R:R:L54	R:R:R58	6.07	No	No	0	8	5
28	R:R:F280	R:R:L54	3.65	Yes	No	0	8	8
29	R:R:L55	R:R:S65	7.51	No	No	0	8	8
30	R:R:L55	R:R:L69	4.15	No	No	0	8	7
31	R:R:F280	R:R:L55	9.74	Yes	No	0	8	8
32	R:R:G56	R:R:R61	4.5	No	No	0	6	7
33	R:R:F280	R:R:M59	3.73	Yes	No	0	8	6
34	R:R:R61	R:R:S65	5.27	No	No	0	7	8
35	R:R:A63	R:R:R141	4.15	No	Yes	0	7	8
36	R:R:F64	R:R:V68	3.93	No	No	0	7	8
37	R:R:F64	R:R:V123	7.87	No	No	1	7	9
38	R:R:F64	R:R:R127	3.21	No	No	1	7	9
39	R:R:S146	R:R:V66	8.08	No	No	0	9	6
40	R:R:T122	R:R:Y67	6.24	No	Yes	0	7	7
41	R:R:E126	R:R:Y67	12.35	No	Yes	0	9	7
42	R:R:S146	R:R:Y67	13.99	No	Yes	0	9	7
43	R:R:V149	R:R:Y67	5.05	No	Yes	0	6	7
44	R:R:F280	R:R:V68	3.93	Yes	No	0	8	8
45	R:R:M119	R:R:S70	7.67	No	No	6	6	9
46	R:R:C150	R:R:S70	5.16	No	No	6	7	9
47	R:R:S70	R:R:W154	4.94	No	No	0	9	9
48	R:R:L71	R:R:M119	5.65	No	No	0	9	6
49	R:R:L71	R:R:N275	4.12	No	Yes	0	9	9
50	R:R:A74	R:R:W154	3.89	No	No	0	9	9
51	R:R:D75	R:R:S272	8.83	No	No	0	9	9
52	R:R:C80	R:R:F76	8.38	No	No	0	4	7
53	R:R:A112	R:R:L77	3.15	No	No	0	7	6
54	R:R:F78	R:R:Q82	8.2	Yes	No	0	6	5
55	R:R:F78	R:R:M109	7.46	Yes	No	0	6	4
56	R:R:F78	R:R:Y113	5.16	Yes	Yes	2	6	8
57	R:R:F78	R:R:S268	3.96	Yes	No	2	6	8
58	R:R:L79	R:R:S272	9.01	No	No	0	7	9
59	R:R:F81	R:R:V108	5.24	No	No	0	5	6
60	R:R:F81	R:R:M109	8.71	No	No	0	5	4
61	R:R:Q82	R:R:V265	5.73	No	No	0	5	4
62	R:R:F101	R:R:I84	3.77	Yes	No	0	4	5
63	R:R:F101	R:R:V88	9.18	Yes	No	0	4	3
64	R:R:C95	R:R:I97	3.27	No	No	0	4	5
65	R:R:I97	R:R:I99	7.36	No	Yes	0	5	1
66	R:R:F101	R:R:P102	5.78	Yes	No	3	4	5
67	R:R:F101	R:R:F105	5.36	Yes	No	3	4	5
68	R:R:F104	R:R:P102	5.78	No	No	3	4	5
69	R:R:F105	R:R:P102	8.67	No	No	3	5	5
70	R:R:F170	R:R:S103	5.28	No	No	0	3	5
71	R:R:F104	R:R:F105	3.22	No	No	3	4	5
72	R:R:F170	R:R:T106	15.56	No	No	0	3	5
73	R:R:S161	R:R:T107	4.8	No	Yes	0	7	4
74	R:R:S161	R:R:T110	4.8	No	No	0	7	2
75	R:R:C111	R:R:S157	5.16	No	No	0	5	8
76	R:R:C111	R:R:L158	6.35	No	No	0	5	4
77	R:R:C111	R:R:S161	3.44	No	No	0	5	7
78	R:R:L114	R:R:Y113	3.52	No	Yes	0	6	8
79	R:R:L117	R:R:Y113	7.03	No	Yes	0	8	8
80	R:R:F239	R:R:Y113	10.32	Yes	Yes	2	6	8
81	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
82	R:R:S268	R:R:Y113	6.36	No	Yes	2	8	8
83	R:R:L114	R:R:S157	6.01	No	No	0	6	8
84	R:R:A115	R:R:W154	11.67	No	No	0	7	9
85	R:R:A115	R:R:S157	3.42	No	No	0	7	8
86	R:R:F232	R:R:L117	6.09	Yes	No	0	9	8
87	R:R:L153	R:R:S118	6.01	No	No	0	7	8
88	R:R:S118	R:R:W190	3.71	No	No	0	8	7
89	R:R:L194	R:R:S118	7.51	No	No	0	8	8
90	R:R:C150	R:R:M119	3.24	No	No	6	7	6
91	R:R:F232	R:R:L120	4.87	Yes	No	0	9	9
92	R:R:L120	R:R:N275	8.24	No	Yes	0	9	9
93	R:R:L120	R:R:Y279	5.86	No	Yes	0	9	9
94	R:R:L194	R:R:S121	6.01	No	No	0	8	7
95	R:R:S121	R:R:V197	3.23	No	No	0	7	6
96	R:R:T122	R:R:T125	3.14	No	No	0	7	7
97	R:R:R127	R:R:V123	6.54	No	No	1	9	9
98	R:R:V123	R:R:Y279	3.79	No	Yes	1	9	9
99	R:R:L198	R:R:S124	9.01	No	No	0	8	9
100	R:R:S124	R:R:S202	3.26	No	No	0	9	8
101	R:R:S201	R:R:T125	4.8	No	No	0	8	7
102	R:R:E126	R:R:Y137	5.61	No	No	5	9	7
103	R:R:E126	R:R:R141	6.98	No	Yes	5	9	8
104	R:R:R127	R:R:Y279	4.12	No	Yes	1	9	9
105	R:R:C128	R:R:L132	3.17	No	No	0	8	6
106	R:R:C128	R:R:S201	3.44	No	No	0	8	8
107	R:R:L129	R:R:W133	4.56	No	No	0	6	5
108	R:R:S130	R:R:V131	3.23	No	No	0	8	8
109	R:R:S130	R:R:Y137	7.63	No	No	0	8	7
110	R:R:L205	R:R:V131	8.94	No	No	0	8	8
111	R:R:L132	R:R:W133	3.42	No	No	0	6	5
112	R:R:R141	R:R:W136	4	Yes	No	0	8	6
113	R:R:R141	R:R:Y137	7.2	Yes	No	5	8	7
114	R:R:L145	R:R:P142	8.21	No	No	0	5	7
115	R:R:H144	R:R:R143	5.64	No	No	0	5	5
116	R:R:L156	R:R:W190	7.97	No	No	0	6	7
117	R:R:L160	R:R:W190	5.69	No	No	0	4	7
118	R:R:F183	R:R:L163	9.74	No	No	0	4	8
119	R:R:E164	R:R:F244	7	No	Yes	0	4	5
120	R:R:F167	R:R:K166	6.2	No	No	0	4	3
121	R:R:F167	R:R:W179	7.02	No	No	0	4	2
122	R:R:C168	R:R:C180	7.28	No	No	0	6	9
123	R:R:D174	R:R:G169	5.03	No	No	0	2	1
124	R:R:D176	R:R:W179	5.58	No	No	0	3	2
125	R:R:S177	R:R:W248	4.94	No	Yes	0	3	3
126	R:R:C180	R:R:W248	5.22	No	Yes	0	9	3
127	R:R:Q181	R:R:W248	14.24	No	Yes	0	3	3
128	R:R:D184	R:R:F244	14.33	No	Yes	0	3	5
129	R:R:D184	R:R:W248	5.58	No	Yes	0	3	3
130	R:R:F185	R:R:L245	6.09	No	No	8	3	5
131	R:R:F185	R:R:I249	3.77	No	No	8	3	1
132	R:R:F244	R:R:T187	9.08	Yes	No	0	5	4
133	R:R:A188	R:R:L245	4.73	No	No	0	5	5
134	R:R:F193	R:R:V197	7.87	No	No	0	5	6
135	R:R:F195	R:R:F232	5.36	Yes	Yes	7	6	9
136	R:R:F195	R:R:L233	4.87	Yes	No	0	6	7
137	R:R:F195	R:R:L237	3.65	Yes	Yes	7	6	6
138	R:R:F232	R:R:L198	18.27	Yes	No	0	9	8
139	R:R:I225	R:R:S202	3.1	No	No	0	7	8
140	R:R:S202	R:R:V229	3.23	No	No	0	8	8
141	R:R:I209	R:R:L205	4.28	Yes	No	0	6	8
142	R:R:I209	R:R:S213	4.64	Yes	No	0	6	7
143	R:R:I209	R:R:L218	4.28	Yes	No	0	6	7
144	R:R:I209	R:R:L221	5.71	Yes	No	0	6	8
145	R:R:L210	R:R:L218	4.15	No	No	0	5	7
146	R:R:L216	R:R:S213	7.51	No	No	0	4	7
147	R:R:T219	R:R:Y222	3.75	No	No	0	5	6
148	R:R:I225	R:R:L221	4.28	No	No	0	7	8
149	R:R:I278	R:R:L227	4.28	Yes	No	0	8	7
150	R:R:T228	R:R:Y279	4.99	No	Yes	0	7	9
151	R:R:I278	R:R:V231	4.61	Yes	No	0	8	7
152	R:R:F232	R:R:L237	7.31	Yes	Yes	7	9	6
153	R:R:C235	R:R:N271	3.15	No	No	0	7	9
154	R:R:G236	R:R:N271	5.09	No	No	0	7	9
155	R:R:I241	R:R:L237	4.28	No	Yes	0	6	6
156	R:R:L267	R:R:P238	3.28	No	No	0	7	9
157	R:R:F239	R:R:S264	6.61	Yes	No	0	6	5
158	R:R:F239	R:R:V265	6.55	Yes	No	0	6	4
159	R:R:F239	R:R:S268	9.25	Yes	No	2	6	8
160	R:R:I241	R:R:I246	4.42	No	No	0	6	4
161	R:R:I260	R:R:Q242	4.12	No	No	0	3	1
162	R:R:H261	R:R:Q242	14.84	Yes	No	0	2	1
163	R:R:Q242	R:R:S264	11.55	No	No	0	1	5
164	R:R:F244	R:R:W243	10.02	Yes	No	0	5	4
165	R:R:H261	R:R:W243	6.35	Yes	No	0	2	4
166	R:R:I249	R:R:L245	4.28	No	No	8	1	5
167	R:R:L247	R:R:L256	6.92	No	No	0	3	2
168	R:R:I260	R:R:L256	4.28	No	No	0	3	2
169	R:R:F257	R:R:H261	10.18	No	Yes	0	3	2
170	R:R:N271	R:R:N275	9.54	No	Yes	0	9	9
171	R:R:S272	R:R:S273	3.26	No	No	0	9	8
172	R:R:I278	R:R:Y279	4.84	Yes	Yes	0	8	9
173	R:R:F280	R:R:F281	7.5	Yes	Yes	4	8	6
174	R:R:F280	R:R:S284	7.93	Yes	No	0	8	7
175	R:R:F281	R:R:F285	6.43	Yes	No	0	6	6
176	R:R:F285	R:R:S284	3.96	No	No	0	6	7
177	R:R:F285	R:R:Q288	15.23	No	No	0	6	4
178	R:R:I162	R:R:T107	3.04	No	Yes	0	4	4
179	R:R:L198	R:R:S121	3	No	No	0	8	7
180	R:R:L145	R:R:V149	2.98	No	No	0	5	6
181	R:R:I192	R:R:M196	2.92	No	No	0	5	5
182	R:R:I162	R:R:L163	2.85	No	No	0	4	8
183	R:R:I209	R:R:L206	2.85	Yes	No	0	6	5
184	R:R:K166	R:R:L163	2.82	No	No	0	3	8
185	R:R:C199	R:R:F195	2.79	No	Yes	0	5	6
186	R:R:L191	R:R:L237	2.77	No	Yes	0	7	6
187	R:R:L226	R:R:L230	2.77	No	No	0	5	5
188	R:R:L233	R:R:L234	2.77	No	No	0	7	5
189	R:R:D75	R:R:N275	2.69	No	Yes	0	9	9
190	R:R:F39	R:R:V43	2.62	No	No	0	5	5
191	R:R:R208	R:R:V131	2.62	No	No	0	7	8
192	R:R:F39	R:R:I40	2.51	No	Yes	0	5	7
193	R:R:F81	R:R:I84	2.51	No	No	0	5	5
194	R:R:F101	R:R:I99	2.51	Yes	Yes	0	4	1
195	R:R:F35	R:R:L38	2.44	No	No	0	4	5
196	R:R:F35	R:R:L90	2.44	No	No	0	4	4
197	R:R:I249	R:R:W250	2.35	No	No	0	1	1
198	R:R:L31	R:R:Y89	2.34	Yes	Yes	0	3	2
199	R:R:D252	R:R:W250	2.23	No	No	0	1	1
200	R:R:G236	R:R:P238	2.03	No	No	0	7	9
201	R:R:R140	R:R:W136	2	No	No	0	6	6
202	R:R:F185	R:R:W248	2	No	Yes	0	3	3
203	R:R:C211	R:R:G212	1.96	No	No	0	5	5
204	R:R:A74	R:R:G116	1.95	No	No	0	9	9
205	R:R:A204	R:R:C128	1.81	No	No	0	6	8
206	R:R:C86	R:R:V34	1.71	No	No	0	5	4
207	R:R:G49	R:R:L52	1.71	No	Yes	0	6	8
208	R:R:C211	R:R:V207	1.71	No	No	0	5	5
209	R:R:D174	R:R:G175	1.68	No	No	0	2	3
210	R:R:D176	R:R:G175	1.68	No	No	0	3	3
211	R:R:C139	R:R:I135	1.64	No	No	0	7	6
212	R:R:E164	R:R:G165	1.64	No	No	0	4	3
213	R:R:L216	R:R:P217	1.64	No	No	0	4	5
214	R:R:S96	R:R:S98	1.63	No	No	0	5	6
215	R:R:A274	R:R:I278	1.62	No	Yes	0	7	8
216	R:R:T106	R:R:T107	1.57	No	Yes	0	5	4
217	R:R:I99	R:R:S91	1.55	Yes	No	0	1	2
218	R:R:H261	R:R:P262	1.53	Yes	No	0	2	1
219	R:R:C258	R:R:E29	1.52	No	No	0	1	1
220	R:R:I225	R:R:T224	1.52	No	No	0	7	7
221	R:R:G215	R:R:R214	1.5	No	No	0	5	5
222	R:R:N62	R:R:S65	1.49	No	No	0	8	8
223	R:R:N92	R:R:S98	1.49	No	No	0	3	6
224	R:R:L152	R:R:V148	1.49	No	No	0	4	4
225	R:R:L203	R:R:V207	1.49	No	No	0	5	5
226	R:R:L267	R:R:V263	1.49	No	No	0	7	5
227	R:R:L171	R:R:T107	1.47	No	Yes	0	1	4
228	R:R:I192	R:R:I241	1.47	No	No	0	5	6
229	R:R:L223	R:R:T219	1.47	No	No	0	6	5
230	R:R:C258	R:R:H259	1.47	No	No	0	1	2
231	R:R:G27	R:R:Y89	1.45	No	Yes	0	1	2
232	R:R:I99	R:R:N92	1.42	Yes	No	0	1	3
233	R:R:K28	R:R:L31	1.41	No	Yes	0	2	3
234	R:R:E29	R:R:T30	1.41	No	No	0	1	3
235	R:R:C95	R:R:F94	1.4	No	No	0	4	3
236	R:R:A112	R:R:F78	1.39	No	Yes	0	7	6
237	R:R:C139	R:R:R138	1.39	No	No	0	7	7
238	R:R:L42	R:R:L45	1.38	No	No	0	5	7
239	R:R:L159	R:R:L160	1.38	No	No	0	4	4
240	R:R:P134	R:R:W133	1.35	No	No	0	9	5
241	R:R:F281	R:R:I277	1.26	Yes	No	0	6	6
242	R:R:L206	R:R:Y222	1.17	No	No	0	5	6
243	R:R:F281	R:R:F50	1.07	Yes	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L31	3.3725	4	0	3
2	R:R:I40	3.605	4	0	7
3	R:R:L52	3.2875	4	0	8
4	R:R:Y67	9.4075	4	0	7
5	R:R:F78	5.234	5	2	6
6	R:R:Y89	4.395	4	0	2
7	R:R:I99	3.21	4	0	1
8	R:R:F101	5.32	5	3	4
9	R:R:T107	2.72	4	0	4
10	R:R:Y113	6.12333	6	2	8
11	R:R:R141	5.5825	4	5	8
12	R:R:F195	4.1675	4	7	6
13	R:R:I209	4.352	5	0	6
14	R:R:F232	8.38	5	7	9
15	R:R:L237	4.5025	4	7	6
16	R:R:F239	8.1825	4	2	6
17	R:R:F244	10.1075	4	0	5
18	R:R:W248	6.396	5	0	3
19	R:R:H261	8.225	4	0	2
20	R:R:N275	6.1475	4	0	9
21	R:R:I278	3.8375	4	0	8
22	R:R:Y279	4.72	5	1	9
23	R:R:F280	6.71	7	4	8
24	R:R:F281	4.038	5	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H261	R:R:Q242	36.8341	14.84	Yes	No	0	2	1
2	R:R:Q242	R:R:S264	42.7883	11.55	No	No	0	1	5
3	R:R:F239	R:R:S264	44.3	6.61	Yes	No	0	6	5
4	R:R:F239	R:R:V265	24.4307	6.55	Yes	No	0	6	4
5	R:R:I37	R:R:V265	25.2228	4.61	No	No	0	6	4
6	R:R:C86	R:R:I37	22.3183	3.27	No	No	0	5	6
7	R:R:C86	R:R:V34	20.8925	1.71	No	No	0	5	4
8	R:R:V34	R:R:Y89	19.3412	5.05	No	Yes	0	4	2
9	R:R:S272	R:R:S273	12.4695	3.26	No	No	0	9	8
10	R:R:D75	R:R:S272	15.9152	8.83	No	No	0	9	9
11	R:R:D75	R:R:N275	20.9849	2.69	No	Yes	0	9	9
12	R:R:L120	R:R:N275	36.6691	8.24	No	Yes	0	9	9
13	R:R:F232	R:R:L120	100	4.87	Yes	No	0	9	9
14	R:R:F232	R:R:L117	97.6434	6.09	Yes	No	0	9	8
15	R:R:L117	R:R:Y113	97.2143	7.03	No	Yes	0	8	8
16	R:R:F239	R:R:Y113	59.6607	10.32	Yes	Yes	2	6	8
17	R:R:F76	R:R:L45	10.5882	8.53	No	No	0	7	7
18	R:R:F76	R:R:L52	15.9086	4.87	No	Yes	0	7	8
19	R:R:A72	R:R:L52	23.7969	3.15	No	Yes	0	9	8
20	R:R:A72	R:R:V51	26.3978	3.39	No	No	0	9	9
21	R:R:F280	R:R:V51	28.6224	10.49	Yes	No	4	8	9
22	R:R:F280	R:R:V68	78.3748	3.93	Yes	No	0	8	8
23	R:R:F64	R:R:V68	80.6984	3.93	No	No	0	7	8
24	R:R:F64	R:R:V123	41.3889	7.87	No	No	1	7	9
25	R:R:V123	R:R:Y279	42.412	3.79	No	Yes	1	9	9
26	R:R:L120	R:R:Y279	89.3062	5.86	No	Yes	0	9	9
27	R:R:F64	R:R:R127	41.3823	3.21	No	No	1	7	9
28	R:R:R127	R:R:Y279	42.3064	4.12	No	Yes	1	9	9
29	R:R:F280	R:R:F281	13.0834	7.5	Yes	Yes	4	8	6
30	R:R:F280	R:R:L54	10.8456	3.65	Yes	No	0	8	8
31	R:R:F280	R:R:L55	16.1925	9.74	Yes	No	0	8	8
32	R:R:L55	R:R:S65	10.8456	7.51	No	No	0	8	8
33	R:R:S130	R:R:Y137	32.9197	7.63	No	No	0	8	7
34	R:R:S130	R:R:V131	34.3521	3.23	No	No	0	8	8
35	R:R:L205	R:R:V131	37.0784	8.94	No	No	0	8	8
36	R:R:I209	R:R:L205	38.4976	4.28	Yes	No	0	6	8
37	R:R:I209	R:R:L221	51.614	5.71	Yes	No	0	6	8
38	R:R:I225	R:R:L221	52.9012	4.28	No	No	0	7	8
39	R:R:I225	R:R:S202	55.2248	3.1	No	No	0	7	8
40	R:R:S124	R:R:S202	57.6672	3.26	No	No	0	9	8
41	R:R:L198	R:R:S124	58.8488	9.01	No	No	0	8	9
42	R:R:F232	R:R:L198	70.8892	18.27	Yes	No	0	9	8
43	R:R:E126	R:R:Y67	24.0412	12.35	No	Yes	0	9	7
44	R:R:E126	R:R:Y137	25.1568	5.61	No	No	5	9	7
45	R:R:T122	R:R:Y67	14.9053	6.24	No	Yes	0	7	7
46	R:R:L114	R:R:S157	35.5733	6.01	No	No	0	6	8
47	R:R:L114	R:R:Y113	36.9001	3.52	No	Yes	0	6	8
48	R:R:L71	R:R:M119	10.0073	5.65	No	No	0	9	6
49	R:R:L71	R:R:N275	11.3341	4.12	No	Yes	0	9	9
50	R:R:F78	R:R:M109	31.3222	7.46	Yes	No	0	6	4
51	R:R:F81	R:R:M109	29.6653	8.71	No	No	0	5	4
52	R:R:F101	R:R:I84	24.5627	3.77	Yes	No	0	4	5
53	R:R:F81	R:R:I84	26.2856	2.51	No	No	0	5	5
54	R:R:F101	R:R:I99	14.2188	2.51	Yes	Yes	0	4	1
55	R:R:S161	R:R:T107	25.7047	4.8	No	Yes	0	7	4
56	R:R:C111	R:R:S161	28.926	3.44	No	No	0	5	7
57	R:R:C111	R:R:S157	32.0945	5.16	No	No	0	5	8
58	R:R:L194	R:R:S121	11.5453	6.01	No	No	0	8	7
59	R:R:L198	R:R:S121	16.3575	3	No	No	0	8	7
60	R:R:T122	R:R:T125	13.3012	3.14	No	No	0	7	7
61	R:R:S201	R:R:T125	11.6839	4.8	No	No	0	8	7
62	R:R:C128	R:R:S201	10.0535	3.44	No	No	0	8	8
63	R:R:I162	R:R:L163	15.7238	2.85	No	No	0	4	8
64	R:R:I162	R:R:T107	17.4203	3.04	No	Yes	0	4	4
65	R:R:F244	R:R:W243	27.6058	10.02	Yes	No	0	5	4
66	R:R:H261	R:R:W243	29.2164	6.35	Yes	No	0	2	4
67	R:R:F167	R:R:K166	10.6872	6.2	No	No	0	4	3
68	R:R:K166	R:R:L163	12.4233	2.82	No	No	0	3	8
69	R:R:D184	R:R:W248	19.427	5.58	No	Yes	0	3	3
70	R:R:D184	R:R:F244	21.1433	14.33	No	Yes	0	3	5
71	R:R:F185	R:R:W248	10.773	2	No	Yes	0	3	3
72	R:R:N271	R:R:N275	10.7268	9.54	No	Yes	0	9	9
73	R:R:F78	R:R:Y113	31.0978	5.16	Yes	Yes	2	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7VV3_nogp

PDB Summary
PDB	7VV3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	236
Number of Links	243
Number of Hubs	24
Number of Links mediated by Hubs	99
Number of Communities	8
Number of Nodes involved in Communities	27
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	31939
Length Of Smallest Path	3
Average Path Length	14.8088
Length of Longest Path	36
Minimum Path Strength	1.165
Average Path Strength	5.99244
Maximum Path Strength	13.64
Minimum Path Correlation	0.7
Average Path Correlation	0.921599
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.2827
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.7888
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • mast cell secretagogue receptor activity • multicellular organismal process • sleep • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • system process • sensory perception • nervous system process • sensory perception of pain • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7VV3_nogp_Chain_R G K E T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G S R G L P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W K D S D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F R K Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VV3_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.