psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K23	R:R:F170	9.93	Yes	Yes	1	0	3
2	L:L:K23	R:R:D184	8.3	Yes	Yes	1	0	3
3	L:L:K23	R:R:W243	6.96	Yes	Yes	1	0	4
4	L:L:K23	R:R:L247	4.23	Yes	No	0	0	3
5	L:L:K23	R:R:W248	4.64	Yes	No	1	0	3
6	L:L:N24	R:R:L247	4.12	No	No	0	0	3
7	L:L:F26	R:R:T106	3.89	Yes	No	1	0	5
8	L:L:F26	R:R:M109	7.46	Yes	Yes	0	0	4
9	L:L:F26	R:R:W243	8.02	Yes	Yes	1	0	4
10	L:L:F26	R:R:H261	6.79	Yes	Yes	1	0	2
11	R:R:F93	R:R:L31	3.65	No	Yes	0	1	3
12	R:R:I32	R:R:P33	3.39	No	No	0	5	4
13	R:R:P262	R:R:P33	3.9	No	No	0	1	4
14	R:R:C86	R:R:V34	3.42	No	No	0	5	4
15	R:R:V34	R:R:Y89	10.09	No	No	0	4	2
16	R:R:F35	R:R:L90	3.65	No	No	0	4	4
17	R:R:I40	R:R:L36	4.28	Yes	No	0	7	5
18	R:R:L36	R:R:V266	4.47	No	No	0	5	5
19	R:R:I37	R:R:Q82	4.12	Yes	Yes	6	6	5
20	R:R:I37	R:R:V265	4.61	Yes	No	6	6	4
21	R:R:I37	R:R:V266	4.61	Yes	No	0	6	5
22	R:R:I37	R:R:S269	7.74	Yes	No	0	6	5
23	R:R:C86	R:R:L38	7.94	No	No	0	5	5
24	R:R:I40	R:R:S269	6.19	Yes	No	0	7	5
25	R:R:I40	R:R:L270	8.56	Yes	No	0	7	6
26	R:R:I40	R:R:S273	4.64	Yes	No	0	7	8
27	R:R:A41	R:R:I83	3.25	No	No	0	5	6
28	R:R:I83	R:R:L42	5.71	No	No	0	6	5
29	R:R:G44	R:R:S273	3.71	No	No	0	9	8
30	R:R:F76	R:R:L45	6.09	Yes	No	0	7	7
31	R:R:I83	R:R:L45	4.28	No	No	0	6	7
32	R:R:A72	R:R:N48	4.69	No	No	0	9	9
33	R:R:D75	R:R:N48	8.08	No	No	0	9	9
34	R:R:N48	R:R:P276	9.77	No	No	0	9	9
35	R:R:F50	R:R:L54	3.65	No	No	0	5	8
36	R:R:P276	R:R:V51	3.53	No	No	0	9	9
37	R:R:F280	R:R:V51	11.8	Yes	No	4	8	9
38	R:R:F281	R:R:V51	6.55	No	No	4	6	9
39	R:R:F76	R:R:L52	4.87	Yes	No	0	7	8
40	R:R:L54	R:R:W53	6.83	No	No	7	8	6
41	R:R:R58	R:R:W53	7	No	No	7	5	6
42	R:R:L54	R:R:R58	6.07	No	No	7	8	5
43	R:R:L55	R:R:R61	4.86	Yes	No	4	8	7
44	R:R:L55	R:R:L69	5.54	Yes	No	4	8	7
45	R:R:F280	R:R:L55	13.4	Yes	Yes	4	8	8
46	R:R:G56	R:R:L69	3.42	No	No	0	6	7
47	R:R:R61	R:R:S65	9.22	No	No	0	7	8
48	R:R:L69	R:R:R61	3.64	No	No	4	7	7
49	R:R:F64	R:R:V68	3.93	No	No	0	7	8
50	R:R:F64	R:R:V123	5.24	No	No	5	7	9
51	R:R:F64	R:R:R127	4.28	No	No	5	7	9
52	R:R:S146	R:R:V66	8.08	No	No	0	9	6
53	R:R:M119	R:R:Y67	3.59	No	Yes	2	6	7
54	R:R:T122	R:R:Y67	3.75	No	Yes	0	7	7
55	R:R:E126	R:R:Y67	13.47	No	Yes	2	9	7
56	R:R:R141	R:R:Y67	5.14	Yes	Yes	2	8	7
57	R:R:S146	R:R:Y67	13.99	No	Yes	0	9	7
58	R:R:V149	R:R:Y67	5.05	No	Yes	0	6	7
59	R:R:F280	R:R:V68	3.93	Yes	No	0	8	8
60	R:R:M119	R:R:S70	9.2	No	No	2	6	9
61	R:R:C150	R:R:S70	6.89	No	No	2	7	9
62	R:R:S70	R:R:W154	7.41	No	No	0	9	9
63	R:R:L71	R:R:N275	8.24	No	Yes	5	9	9
64	R:R:L71	R:R:Y279	5.86	No	Yes	5	9	9
65	R:R:A74	R:R:W154	3.89	No	No	0	9	9
66	R:R:D75	R:R:S272	7.36	No	No	0	9	9
67	R:R:D75	R:R:N275	5.39	No	Yes	0	9	9
68	R:R:A112	R:R:L77	3.15	No	No	0	7	6
69	R:R:F78	R:R:M109	6.22	No	Yes	0	6	4
70	R:R:F78	R:R:Y113	7.22	No	Yes	1	6	8
71	R:R:F239	R:R:F78	4.29	Yes	No	1	6	6
72	R:R:L79	R:R:S272	7.51	No	No	0	7	9
73	R:R:F105	R:R:F81	8.57	No	Yes	0	5	5
74	R:R:F81	R:R:V108	5.24	Yes	No	0	5	6
75	R:R:F81	R:R:M109	7.46	Yes	Yes	0	5	4
76	R:R:N85	R:R:Q82	3.96	No	Yes	0	4	5
77	R:R:M109	R:R:Q82	4.08	Yes	Yes	0	4	5
78	R:R:Q82	R:R:V265	8.6	Yes	No	6	5	4
79	R:R:F101	R:R:I84	3.77	No	No	0	4	5
80	R:R:F93	R:R:F94	6.43	No	No	0	1	3
81	R:R:C95	R:R:I97	3.27	No	No	0	4	5
82	R:R:I97	R:R:I99	4.42	No	No	0	5	1
83	R:R:F101	R:R:P102	11.56	No	No	8	4	5
84	R:R:F101	R:R:F105	8.57	No	No	8	4	5
85	R:R:F105	R:R:P102	5.78	No	No	8	5	5
86	R:R:S103	R:R:T106	3.2	No	No	1	5	5
87	R:R:F170	R:R:S103	3.96	Yes	No	1	3	5
88	R:R:F104	R:R:L171	7.31	No	Yes	0	4	1
89	R:R:F170	R:R:T106	9.08	Yes	No	1	3	5
90	R:R:S161	R:R:T107	4.8	No	No	0	7	4
91	R:R:L171	R:R:T107	5.9	Yes	No	0	1	4
92	R:R:S161	R:R:T110	6.4	No	No	0	7	2
93	R:R:C111	R:R:S157	5.16	No	No	0	5	8
94	R:R:C111	R:R:L158	6.35	No	No	0	5	4
95	R:R:C111	R:R:S161	3.44	No	No	0	5	7
96	R:R:L117	R:R:Y113	8.21	No	Yes	0	8	8
97	R:R:F239	R:R:Y113	17.54	Yes	Yes	1	6	8
98	R:R:G240	R:R:Y113	4.35	No	Yes	0	7	8
99	R:R:S268	R:R:Y113	5.09	No	Yes	1	8	8
100	R:R:A115	R:R:W154	11.67	No	No	0	7	9
101	R:R:A115	R:R:S157	3.42	No	No	0	7	8
102	R:R:L117	R:R:L191	5.54	No	No	0	8	7
103	R:R:F232	R:R:L117	6.09	Yes	No	0	9	8
104	R:R:L153	R:R:S118	4.5	No	No	0	7	8
105	R:R:S118	R:R:W190	4.94	No	No	9	8	7
106	R:R:L194	R:R:S118	7.51	No	No	9	8	8
107	R:R:C150	R:R:M119	4.86	No	No	2	7	6
108	R:R:F232	R:R:L120	8.53	Yes	No	0	9	9
109	R:R:L120	R:R:Y279	17.58	No	Yes	0	9	9
110	R:R:L194	R:R:S121	4.5	No	No	0	8	7
111	R:R:S121	R:R:V197	3.23	No	No	0	7	6
112	R:R:L198	R:R:S121	4.5	No	No	0	8	7
113	R:R:R127	R:R:V123	6.54	No	No	5	9	9
114	R:R:V123	R:R:Y279	3.79	No	Yes	5	9	9
115	R:R:L198	R:R:S124	4.5	No	No	0	8	9
116	R:R:S124	R:R:S201	3.26	No	No	0	9	8
117	R:R:S124	R:R:S202	4.89	No	No	0	9	8
118	R:R:S201	R:R:T125	6.4	No	No	0	8	7
119	R:R:E126	R:R:Y137	5.61	No	No	2	9	7
120	R:R:E126	R:R:R141	9.3	No	Yes	2	9	8
121	R:R:C128	R:R:L132	3.17	No	No	0	8	6
122	R:R:C128	R:R:S201	3.44	No	No	0	8	8
123	R:R:S130	R:R:V131	3.23	No	No	0	8	8
124	R:R:S130	R:R:Y137	7.63	No	No	0	8	7
125	R:R:L205	R:R:V131	4.47	No	No	0	8	8
126	R:R:L132	R:R:W133	4.56	No	No	0	6	5
127	R:R:L132	R:R:R208	3.64	No	No	0	6	7
128	R:R:I135	R:R:P134	3.39	No	No	0	6	9
129	R:R:R140	R:R:W136	7	No	No	0	6	6
130	R:R:R141	R:R:Y137	18.52	Yes	No	2	8	7
131	R:R:C139	R:R:R138	4.18	No	No	0	7	7
132	R:R:L145	R:R:R141	3.64	No	Yes	0	5	8
133	R:R:L145	R:R:P142	8.21	No	No	0	5	7
134	R:R:H144	R:R:R143	10.16	No	No	0	5	5
135	R:R:L156	R:R:W190	7.97	No	No	0	6	7
136	R:R:L160	R:R:T187	5.9	No	No	0	4	4
137	R:R:F167	R:R:L163	9.74	Yes	No	3	4	8
138	R:R:F183	R:R:L163	3.65	Yes	No	3	4	8
139	R:R:C168	R:R:E164	7.6	No	No	0	6	4
140	R:R:E164	R:R:F170	4.66	No	Yes	0	4	3
141	R:R:G165	R:R:L171	3.42	No	Yes	0	3	1
142	R:R:K166	R:R:L171	7.05	Yes	Yes	0	3	1
143	R:R:F172	R:R:K166	4.96	No	Yes	3	1	3
144	R:R:K166	R:R:S173	6.12	Yes	No	3	3	1
145	R:R:F167	R:R:W179	8.02	Yes	No	3	4	2
146	R:R:F167	R:R:F183	7.5	Yes	Yes	3	4	4
147	R:R:C168	R:R:C180	7.28	No	No	0	6	9
148	R:R:F170	R:R:W243	4.01	Yes	Yes	1	3	4
149	R:R:F172	R:R:S173	6.61	No	No	3	1	1
150	R:R:D174	R:R:G175	3.35	No	No	0	2	3
151	R:R:D176	R:R:W179	5.58	No	No	0	3	2
152	R:R:G178	R:R:S177	3.71	No	No	0	3	3
153	R:R:G178	R:R:Q181	4.93	No	No	0	3	3
154	R:R:F183	R:R:W179	12.03	Yes	No	3	4	2
155	R:R:Q181	R:R:W248	13.14	No	No	0	3	3
156	R:R:F183	R:R:T182	3.89	Yes	No	0	4	2
157	R:R:D184	R:R:T187	4.34	Yes	No	1	3	4
158	R:R:D184	R:R:F244	9.55	Yes	No	1	3	5
159	R:R:D184	R:R:W248	4.47	Yes	No	1	3	3
160	R:R:F185	R:R:I249	5.02	No	No	0	3	1
161	R:R:F244	R:R:T187	9.08	No	No	1	5	4
162	R:R:A188	R:R:L245	3.15	No	No	0	5	5
163	R:R:L194	R:R:W190	15.94	No	No	9	8	7
164	R:R:F193	R:R:V197	7.87	No	No	0	5	6
165	R:R:F195	R:R:F232	7.5	Yes	Yes	0	6	9
166	R:R:F195	R:R:L233	7.31	Yes	No	0	6	7
167	R:R:F195	R:R:L237	6.09	Yes	No	0	6	6
168	R:R:F232	R:R:L198	13.4	Yes	No	0	9	8
169	R:R:I225	R:R:S202	3.1	Yes	No	0	7	8
170	R:R:S202	R:R:V229	3.23	No	No	0	8	8
171	R:R:I225	R:R:L205	4.28	Yes	No	0	7	8
172	R:R:I225	R:R:L206	5.71	Yes	No	0	7	5
173	R:R:I209	R:R:S213	9.29	No	No	0	6	7
174	R:R:I209	R:R:L221	5.71	No	No	0	6	8
175	R:R:L216	R:R:S213	4.5	No	No	0	4	7
176	R:R:L216	R:R:P217	3.28	No	No	0	4	5
177	R:R:I225	R:R:L221	4.28	Yes	No	0	7	8
178	R:R:L223	R:R:Y222	8.21	No	No	0	6	6
179	R:R:I278	R:R:L227	4.28	No	No	0	8	7
180	R:R:T228	R:R:Y279	4.99	No	Yes	0	7	9
181	R:R:L230	R:R:L234	6.92	No	No	0	5	5
182	R:R:N271	R:R:V231	4.43	No	No	0	9	7
183	R:R:C235	R:R:L234	3.17	No	No	0	7	5
184	R:R:G236	R:R:N271	5.09	No	No	0	7	9
185	R:R:L267	R:R:P238	4.93	No	No	0	7	9
186	R:R:F239	R:R:Q242	4.68	Yes	Yes	1	6	1
187	R:R:F239	R:R:W243	8.02	Yes	Yes	1	6	4
188	R:R:F239	R:R:S268	5.28	Yes	No	1	6	8
189	R:R:I241	R:R:L245	4.28	No	No	0	6	5
190	R:R:Q242	R:R:W243	3.29	Yes	Yes	1	1	4
191	R:R:H261	R:R:Q242	14.84	Yes	Yes	1	2	1
192	R:R:Q242	R:R:S264	8.66	Yes	No	0	1	5
193	R:R:F244	R:R:W243	9.02	No	Yes	1	5	4
194	R:R:H261	R:R:W243	4.23	Yes	Yes	1	2	4
195	R:R:D252	R:R:D254	3.99	No	No	0	1	1
196	R:R:D254	R:R:V255	4.38	No	No	0	1	1
197	R:R:I260	R:R:S264	3.1	No	No	0	3	5
198	R:R:N271	R:R:N275	5.45	No	Yes	0	9	9
199	R:R:N275	R:R:Y279	8.14	Yes	Yes	5	9	9
200	R:R:I277	R:R:P276	5.08	No	No	0	6	9
201	R:R:F280	R:R:F281	3.22	Yes	No	4	8	6
202	R:R:F280	R:R:S284	3.96	Yes	No	0	8	7
203	R:R:F285	R:R:S284	3.96	No	No	0	6	7
204	R:R:H261	R:R:P262	3.05	Yes	No	0	2	1
205	R:R:F76	R:R:G49	3.01	Yes	No	0	7	6
206	R:R:F57	R:R:W53	3.01	No	No	0	5	6
207	R:R:F57	R:R:G56	3.01	No	No	0	5	6
208	R:R:L114	R:R:S157	3	No	No	0	6	8
209	R:R:R141	R:R:W136	3	Yes	No	0	8	6
210	R:R:N62	R:R:S65	2.98	No	No	0	8	8
211	R:R:I241	R:R:I246	2.94	No	No	0	6	4
212	R:R:I162	R:R:L171	2.85	No	Yes	0	4	1
213	R:R:I209	R:R:L218	2.85	No	No	0	6	7
214	R:R:I241	R:R:L237	2.85	No	No	0	6	6
215	R:R:I249	R:R:L245	2.85	No	No	0	1	5
216	R:R:I260	R:R:L256	2.85	No	No	0	3	2
217	R:R:L55	R:R:M59	2.83	Yes	No	0	8	6
218	R:R:C80	R:R:F81	2.79	No	Yes	0	4	5
219	R:R:L38	R:R:L42	2.77	No	No	0	5	5
220	R:R:A63	R:R:R141	2.77	No	Yes	0	7	8
221	R:R:H259	R:R:I260	2.65	No	No	0	2	3
222	R:R:I135	R:R:R140	2.51	No	No	0	6	6
223	R:R:F195	R:R:I192	2.51	Yes	No	0	6	5
224	R:R:F167	R:R:K166	2.48	Yes	Yes	3	4	3
225	R:R:F35	R:R:L31	2.44	No	Yes	0	4	3
226	L:L:F25	R:R:N100	2.42	No	No	0	0	1
227	R:R:I246	R:R:W250	2.35	No	No	0	4	1
228	R:R:L31	R:R:Y89	2.34	Yes	No	0	3	2
229	R:R:L129	R:R:W133	2.28	No	No	0	6	5
230	R:R:G236	R:R:P238	2.03	No	No	0	7	9
231	R:R:C199	R:R:G200	1.96	No	No	0	5	4
232	R:R:A74	R:R:G116	1.95	No	No	0	9	9
233	R:R:G283	R:R:V282	1.84	No	No	0	9	7
234	R:R:A204	R:R:C128	1.81	No	No	0	6	8
235	R:R:G215	R:R:L216	1.71	No	No	0	5	4
236	R:R:C235	R:R:V231	1.71	No	No	0	7	7
237	R:R:C258	R:R:T30	1.69	No	No	0	1	3
238	R:R:D176	R:R:G175	1.68	No	No	0	3	3
239	R:R:C139	R:R:I135	1.64	No	No	0	7	6
240	R:R:S96	R:R:S98	1.63	No	No	0	5	6
241	R:R:S273	R:R:V43	1.62	No	No	0	8	5
242	R:R:C80	R:R:L45	1.59	No	No	0	4	7
243	R:R:C199	R:R:L203	1.59	No	No	0	5	5
244	R:R:I97	R:R:S91	1.55	No	No	0	5	2
245	R:R:I278	R:R:T224	1.52	No	No	0	8	7
246	R:R:F76	R:R:G73	1.51	Yes	No	0	7	5
247	R:R:G212	R:R:R208	1.5	No	No	0	5	7
248	R:R:G215	R:R:R214	1.5	No	No	0	5	5
249	R:R:L77	R:R:V108	1.49	No	No	0	6	6
250	R:R:N92	R:R:S91	1.49	No	No	0	3	2
251	R:R:L226	R:R:V229	1.49	No	No	0	5	8
252	R:R:N92	R:R:V88	1.48	No	No	0	3	3
253	R:R:L31	R:R:T30	1.47	Yes	No	0	3	3
254	R:R:L218	R:R:T219	1.47	No	No	0	7	5
255	R:R:A147	R:R:H144	1.46	No	No	0	5	5
256	R:R:P217	R:R:R220	1.44	No	No	0	5	8
257	R:R:C95	R:R:F94	1.4	No	No	0	4	3
258	R:R:L38	R:R:L87	1.38	No	No	0	5	4
259	R:R:L87	R:R:L90	1.38	No	No	0	4	4
260	R:R:L206	R:R:L210	1.38	No	No	0	5	5
261	R:R:R220	R:R:T224	1.29	No	No	0	8	7
262	R:R:F183	R:R:I186	1.26	Yes	No	0	4	6
263	R:R:T219	R:R:Y222	1.25	No	No	0	5	6
264	R:R:F257	R:R:H261	1.13	No	Yes	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:K23	6.812	5	1	0
2	L:L:F26	6.54	4	1	0
3	R:R:L31	2.475	4	0	3
4	R:R:I37	5.27	4	6	6
5	R:R:I40	5.9175	4	0	7
6	R:R:L55	6.6575	4	4	8
7	R:R:Y67	7.49833	6	2	7
8	R:R:F76	3.87	4	0	7
9	R:R:F81	6.015	4	0	5
10	R:R:Q82	5.19	4	6	5
11	R:R:M109	6.305	4	0	4
12	R:R:Y113	8.482	5	1	8
13	R:R:R141	7.06167	6	2	8
14	R:R:K166	5.1525	4	3	3
15	R:R:F167	6.935	4	3	4
16	R:R:F170	6.328	5	1	3
17	R:R:L171	5.306	5	0	1
18	R:R:F183	5.666	5	3	4
19	R:R:D184	6.665	4	1	3
20	R:R:F195	5.8525	4	0	6
21	R:R:I225	4.3425	4	0	7
22	R:R:F232	8.88	4	0	9
23	R:R:F239	7.962	5	1	6
24	R:R:Q242	7.8675	4	1	1
25	R:R:W243	6.22143	7	1	4
26	R:R:H261	6.008	5	1	2
27	R:R:N275	6.805	4	5	9
28	R:R:Y279	8.072	5	5	9
29	R:R:F280	7.262	5	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K23	R:R:W243	10.3499	6.96	Yes	Yes	1	0	4
2	L:L:F26	R:R:M109	13.1615	7.46	Yes	Yes	0	0	4
3	R:R:F81	R:R:M109	56.456	7.46	Yes	Yes	0	5	4
4	R:R:C80	R:R:F81	48.2402	2.79	No	Yes	0	4	5
5	R:R:C80	R:R:L45	47.1451	1.59	No	No	0	4	7
6	R:R:I83	R:R:L45	41.634	4.28	No	No	0	6	7
7	R:R:I83	R:R:L42	39.3165	5.71	No	No	0	6	5
8	R:R:L38	R:R:L42	38.1399	2.77	No	No	0	5	5
9	R:R:C86	R:R:L38	18.5657	7.94	No	No	0	5	5
10	R:R:C86	R:R:V34	17.2872	3.42	No	No	0	5	4
11	R:R:V34	R:R:Y89	16.0088	10.09	No	No	0	4	2
12	R:R:L31	R:R:Y89	14.7201	2.34	Yes	No	0	3	2
13	R:R:F93	R:R:L31	21.6982	3.65	No	Yes	0	1	3
14	R:R:L38	R:R:L87	18.4231	1.38	No	No	0	5	4
15	R:R:L87	R:R:L90	17.2923	1.38	No	No	0	4	4
16	R:R:F35	R:R:L90	15.9986	3.65	No	No	0	4	4
17	R:R:F35	R:R:L31	14.7252	2.44	No	Yes	0	4	3
18	R:R:M109	R:R:Q82	16.8492	4.08	Yes	Yes	0	4	5
19	R:R:I37	R:R:Q82	12.8304	4.12	Yes	Yes	6	6	5
20	R:R:F239	R:R:W243	24.3366	8.02	Yes	Yes	1	6	4
21	R:R:F239	R:R:Y113	34.1262	17.54	Yes	Yes	1	6	8
22	R:R:L117	R:R:Y113	93.2664	8.21	No	Yes	0	8	8
23	R:R:F232	R:R:L117	94.0508	6.09	Yes	No	0	9	8
24	R:R:F232	R:R:L120	51.2657	8.53	Yes	No	0	9	9
25	R:R:L120	R:R:Y279	50.2368	17.58	No	Yes	0	9	9
26	R:R:N275	R:R:Y279	22.0955	8.14	Yes	Yes	5	9	9
27	R:R:D75	R:R:N275	11.1852	5.39	No	Yes	0	9	9
28	R:R:V123	R:R:Y279	26.9495	3.79	No	Yes	5	9	9
29	R:R:F64	R:R:V123	24.5148	5.24	No	No	5	7	9
30	R:R:F64	R:R:V68	23.5165	3.93	No	No	0	7	8
31	R:R:F280	R:R:V68	22.3145	3.93	Yes	No	0	8	8
32	R:R:F280	R:R:L55	17.0478	13.4	Yes	Yes	4	8	8
33	R:R:L55	R:R:L69	10.0138	5.54	Yes	No	4	8	7
34	R:R:F232	R:R:L198	100	13.4	Yes	No	0	9	8
35	R:R:L198	R:R:S124	98.039	4.5	No	No	0	8	9
36	R:R:S124	R:R:S202	95.0084	4.89	No	No	0	9	8
37	R:R:I225	R:R:S202	93.8216	3.1	Yes	No	0	7	8
38	R:R:I225	R:R:L205	85.3868	4.28	Yes	No	0	7	8
39	R:R:L205	R:R:V131	84.8011	4.47	No	No	0	8	8
40	R:R:S130	R:R:V131	84.3121	3.23	No	No	0	8	8
41	R:R:S130	R:R:Y137	83.7111	7.63	No	No	0	8	7
42	R:R:E126	R:R:Y137	37.0142	5.61	No	No	2	9	7
43	R:R:E126	R:R:Y67	36.1636	13.47	No	Yes	2	9	7
44	R:R:R141	R:R:Y137	46.0755	18.52	Yes	No	2	8	7
45	R:R:R141	R:R:Y67	37.7629	5.14	Yes	Yes	2	8	7
46	R:R:M119	R:R:Y67	64.1726	3.59	No	Yes	2	6	7
47	R:R:M119	R:R:S70	60.0367	9.2	No	No	2	6	9
48	R:R:S70	R:R:W154	58.1674	7.41	No	No	0	9	9
49	R:R:F93	R:R:F94	19.0343	6.43	No	No	0	1	3
50	R:R:C95	R:R:F94	16.3449	1.4	No	No	0	4	3
51	R:R:C95	R:R:I97	13.6454	3.27	No	No	0	4	5
52	R:R:A115	R:R:W154	52.0705	11.67	No	No	0	7	9
53	R:R:A115	R:R:S157	50.0178	3.42	No	No	0	7	8
54	R:R:C111	R:R:S157	45.8819	5.16	No	No	0	5	8
55	R:R:C111	R:R:S161	41.7053	3.44	No	No	0	5	7
56	R:R:S161	R:R:T107	37.4879	4.8	No	No	0	7	4
57	R:R:L171	R:R:T107	35.3639	5.9	Yes	No	0	1	4
58	R:R:L198	R:R:S121	11.1649	4.5	No	No	0	8	7
59	R:R:S124	R:R:S201	12.4484	3.26	No	No	0	9	8
60	R:R:K166	R:R:L171	26.7662	7.05	Yes	Yes	0	3	1
61	R:R:F167	R:R:K166	20.2109	2.48	Yes	Yes	3	4	3
62	R:R:F195	R:R:F232	15.2346	7.5	Yes	Yes	0	6	9
63	R:R:F195	R:R:L237	11.2005	6.09	Yes	No	0	6	6
64	R:R:I225	R:R:L221	20.2516	4.28	Yes	No	0	7	8
65	R:R:I209	R:R:L221	18.9528	5.71	No	No	0	6	8
66	R:R:I209	R:R:S213	12.4586	9.29	No	No	0	6	7
67	R:R:L216	R:R:S213	11.1038	4.5	No	No	0	4	7
68	R:R:N271	R:R:N275	11.771	5.45	No	Yes	0	9	9
69	R:R:F78	R:R:M109	59.1249	6.22	No	Yes	0	6	4
70	R:R:F78	R:R:Y113	57.6835	7.22	No	Yes	1	6	8
71	R:R:F239	R:R:Q242	10.8287	4.68	Yes	Yes	1	6	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K23	R:R:F170	9.93	1	Yes	Yes	0	3	0	1
L:L:K23	R:R:D184	8.3	1	Yes	Yes	0	3	0	1
L:L:K23	R:R:W243	6.96	1	Yes	Yes	0	4	0	1
L:L:K23	R:R:L247	4.23	1	Yes	No	0	3	0	1
L:L:K23	R:R:W248	4.64	1	Yes	No	0	3	0	1
L:L:N24	R:R:L247	4.12	0	No	No	0	3	0	1
L:L:F26	R:R:T106	3.89	1	Yes	No	0	5	0	1
L:L:F26	R:R:M109	7.46	1	Yes	Yes	0	4	0	1
L:L:F26	R:R:W243	8.02	1	Yes	Yes	0	4	0	1
L:L:F26	R:R:H261	6.79	1	Yes	Yes	0	2	0	1
R:R:F78	R:R:M109	6.22	1	No	Yes	6	4	2	1
R:R:F239	R:R:F78	4.29	1	Yes	No	6	6	2	2
R:R:F81	R:R:M109	7.46	0	Yes	Yes	5	4	2	1
R:R:M109	R:R:Q82	4.08	0	Yes	Yes	4	5	1	2
R:R:S103	R:R:T106	3.2	1	No	No	5	5	2	1
R:R:F170	R:R:S103	3.96	1	Yes	No	3	5	1	2
R:R:F170	R:R:T106	9.08	1	Yes	No	3	5	1	1
R:R:E164	R:R:F170	4.66	0	No	Yes	4	3	2	1
R:R:F170	R:R:W243	4.01	1	Yes	Yes	3	4	1	1
R:R:Q181	R:R:W248	13.14	0	No	No	3	3	2	1
R:R:D184	R:R:T187	4.34	1	Yes	No	3	4	1	2
R:R:D184	R:R:F244	9.55	1	Yes	No	3	5	1	2
R:R:D184	R:R:W248	4.47	1	Yes	No	3	3	1	1
R:R:F244	R:R:T187	9.08	1	No	No	5	4	2	2
R:R:F239	R:R:Q242	4.68	1	Yes	Yes	6	1	2	2
R:R:F239	R:R:W243	8.02	1	Yes	Yes	6	4	2	1
R:R:Q242	R:R:W243	3.29	1	Yes	Yes	1	4	2	1
R:R:H261	R:R:Q242	14.84	1	Yes	Yes	2	1	1	2
R:R:F244	R:R:W243	9.02	1	No	Yes	5	4	2	1
R:R:H261	R:R:W243	4.23	1	Yes	Yes	2	4	1	1
R:R:H261	R:R:P262	3.05	1	Yes	No	2	1	1	2
L:L:F25	R:R:N100	2.42	0	No	No	0	1	0	1
R:R:F257	R:R:H261	1.13	0	No	Yes	3	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VDL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	242
Number of Links	264
Number of Hubs	29
Number of Links mediated by Hubs	109
Number of Communities	9
Number of Nodes involved in Communities	54
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	37108
Length Of Smallest Path	3
Average Path Length	17.9007
Length of Longest Path	47
Minimum Path Strength	1.36
Average Path Strength	6.24893
Maximum Path Strength	13.73
Minimum Path Correlation	0.7
Average Path Correlation	0.924031
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	41.658
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.5949
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of biological process • regulation of cell motility • regulation of cellular process • regulation of locomotion • regulation of cell migration • biological regulation • cellular process • cell migration • cell motility • locomotion • trans-synaptic signaling • synaptic signaling • signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • cell communication • cellular response to stimulus • response to stimulus • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular anatomical structure • extracellular region • extracellular space • synapse • cell junction • binding • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • mast cell secretagogue receptor activity • G protein-coupled opioid receptor activity • multicellular organismal process • sleep • response to stress • multicellular organismal response to stress • response to pain • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of locomotion • positive regulation of cell migration • positive regulation of cell motility • myeloid leukocyte migration • regulation of immune system process • positive regulation of immune system process • regulation of leukocyte migration • positive regulation of neutrophil migration • positive regulation of leukocyte migration • neutrophil migration • granulocyte migration • leukocyte migration • regulation of neutrophil migration • system process • sensory perception • nervous system process • sensory perception of pain • membrane • cell periphery • plasma membrane • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cellular component organization or biogenesis • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Cortistatin-14
UniProt	O00230
Sequence	>7VDL_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q96LB1
Sequence	>7VDL_nogp_Chain_R T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M R R N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S I S I N F P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P I W Y R C R R P R H L S A V V C V L L W A L S L L L S I L E G K F C G F L F S D G D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G S R G L P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W K D S D V L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7S8L	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8L (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.45	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8M (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		2.54	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8N (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.9	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-	Gi1/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8O (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	R-Zinc-3573	-		2.58	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7VDH	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDH (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.9	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	Gi1/β1/γ2	3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDL (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-		3.22	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-	Gi1/β1/γ2	2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VDM (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Substance-P	-		2.98	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUY (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.84	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VUZ (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.89	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV0	A	Orphan	Orphan	MRGPRX2	Homo sapiens	PAMP-12	-	-	3.5	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV3 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	-	-		2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV4	A	Orphan	Orphan	MRGPRX2	Homo sapiens	Cortistatin-14	-	-	2.97	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	Gi1/β1/γ2	2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV5 (No Gprot)	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-		2.76	2021-12-01	doi.org/10.1038/s41586-021-04077-y
	7VV6	A	Orphan	Orphan	MRGPRX2	Homo sapiens	C48/80	-	-	3.3	2021-12-01	doi.org/10.1038/s41586-021-04077-y

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.